MCID: SYR003
MIFTS: 37

Syringoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Syringoma

MalaCards integrated aliases for Syringoma:

Name: Syringoma 12 52 54 43 15 71
Syringomas 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2065
MeSH 43 D018252
NCIt 49 C3761
SNOMED-CT 67 71244007
UMLS 71 C0206673

Summaries for Syringoma

NIH Rare Diseases : 52 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes, but may also appear elsewhere on the face, in the armpits, umbilicus, upper chest, and genitalia. They arise from the sweat ducts and may occur suddenly in crops or multiples. There are 4 types of syringoma: a localized form, a form associated with Down syndrome , a generalized form that encompases multiple and eruptive syringomas, and a familial form. Syringomas are usually asymptomatic; However, rarely, individuals can experience extreme itching (pruritus), especially while sweating. They are found more commonly in Caucasians, and in females at puberty or near middle-age. Syringomas may be treated surgically using different methods such as high frequency electric current (electrosurgery ) or laser .

MalaCards based summary : Syringoma, also known as syringomas, is related to vulvar syringoma and malignant syringoma. An important gene associated with Syringoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and Signaling by ERBB4. The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include skin, breast and eye.

Wikipedia : 74 Syringomas are benign eccrine sweat duct tumors, typically found clustered on eyelids, although they may... more...

Related Diseases for Syringoma

Diseases in the Syringoma family:

Syringomas, Multiple Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 448)
# Related Disease Score Top Affiliating Genes
1 vulvar syringoma 34.0 ESR1 CEACAM5
2 malignant syringoma 32.2 KRT7 DAND5 CLEC2A CEACAM5
3 malignant acrospiroma 31.4 DAND5 CLEC2A CEACAM5
4 epidermoid cysts 30.4 S100B S100A1
5 myxoid chondrosarcoma 30.4 S100B MUC1 GFAP
6 osteochondroma 30.3 VIM S100B
7 chondrosarcoma 30.3 VIM S100B S100A1 MUC1
8 neuroma 30.1 S100B MUC1 GFAP
9 nodular hidradenoma 29.6 VIM MUC1 CLEC2A CEACAM5
10 ossifying fibromyxoid tumor 29.6 VIM S100B S100A1 MUC1 DES
11 mammary paget's disease 29.6 MUC1 KRT7 ESR1
12 syringocystadenoma papilliferum 29.6 S100B MUC1 KRT19 GFAP DES
13 brooke-spiegler syndrome 29.5 VIM KRT7 KRT19
14 vulvar disease 29.4 KRT7 CEACAM5
15 cystic teratoma 29.3 KRT7 GFAP CEACAM5
16 fibroma 29.0 VIM S100A1 KRT7 KRT19 DES
17 benign teratoma 29.0 KRT7 CLEC2A CEACAM5
18 carcinosarcoma 29.0 VIM S100A1 MUC1 KRT7 DES
19 renal cell carcinoma, nonpapillary 29.0 VIM S100A1 MUC1 KRT7 KRT19
20 sweat gland neoplasm 29.0 KRT7 GFAP CLEC2A CEACAM5
21 polycystic liver disease 1 with or without kidney cysts 28.9 MUC1 KRT7 KRT19 CEACAM5
22 hidradenoma 28.9 VIM MUC1 KRT7 CLEC2A CEACAM5
23 pleomorphic adenoma 28.9 VIM SERPINB5 S100B S100A1 MUC1 KRT7
24 hidrocystoma 28.8 KRT7 KRT19 CLEC2A CEACAM5
25 eccrine acrospiroma 28.8 KRT7 KRT19 CLEC2A CEACAM5
26 eccrine sweat gland neoplasm 28.8 KRT7 KRT19 CLEC2A CEACAM5
27 spiradenoma 28.8 VIM S100B S100A1 MUC1 KRT7 CLEC2A
28 papillary adenocarcinoma 28.7 VIM MUC1 KRT7 KRT19 CEACAM5
29 adenoid cystic carcinoma 28.6 VIM SERPINB5 S100B S100A1 MUC1 KRT7
30 sweat gland cancer 28.2 KRT7 KRT19 ESR1 CLEC2A CEACAM5
31 syringomas, multiple 12.4
32 chondroid syringoma of the vulva 12.3
33 skin benign neoplasm 10.6
34 adenoma 10.6
35 rare tumor 10.5
36 down syndrome 10.5
37 endometrial mucinous adenocarcinoma 10.5 VIM MUC1
38 hydromyelia 10.5 VIM S100B
39 sclerosing perineurioma 10.5 S100B MUC1
40 localized hypertrophic neuropathy 10.5 S100B MUC1
41 bednar tumor 10.5 VIM S100B
42 primary hepatic neuroendocrine carcinoma 10.5 VIM S100B
43 reticular perineurioma 10.5 S100B MUC1
44 non-functioning pituitary adenoma 10.5 S100B MUC1
45 aggressive digital papillary adenocarcinoma 10.5 S100B MUC1
46 malignant iris melanoma 10.5 S100B S100A1
47 cerebral primitive neuroectodermal tumor 10.5 S100B MUC1
48 meningeal melanocytoma 10.5 S100B MUC1
49 chronic tympanitis 10.5 MUC1 ESR1
50 infantile digital fibromatosis 10.5 VIM DES

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to Syringoma

Symptoms & Phenotypes for Syringoma

Drugs & Therapeutics for Syringoma

Drugs for Syringoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Trial of Postoperative Radiotherapy and Panitumumab in High-risk Salivary Gland Malignancies Withdrawn NCT00984217 Phase 2 Panitumumab
2 Laser Treatment of Genito-urinary Syndrome in Women With Breast and Endometrial Cancer and Menopausal Women Not yet recruiting NCT03238053

Search NIH Clinical Center for Syringoma

Cochrane evidence based reviews: syringoma

Genetic Tests for Syringoma

Anatomical Context for Syringoma

MalaCards organs/tissues related to Syringoma:

40
Skin, Breast, Eye, Salivary Gland, Liver, Colon, Bone

Publications for Syringoma

Articles related to Syringoma:

(show top 50) (show all 824)
# Title Authors PMID Year
1
Malignant chondroid syringoma with bone invasion: a case report and review of the literature. 54 61
15365374 2004
2
Expression of S100A2 and S100B proteins in epithelial tumors of the skin. 54 61
12834486 2003
3
Immunohistochemical analysis of keratin expression in clear cell syringoma. A comparative study with conventional syringoma. 54 61
9243365 1997
4
Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins. 54 61
8835171 1995
5
[Chondroid syringoma. Immunohistologic indications of myoepithelial differentiation]. 54 61
8050903 1994
6
Sweat gland adenomas: immunohistochemical study with emphasis on myoepithelial differentiation. 54 61
7693778 1993
7
Microcystic adnexal carcinoma. An immunohistochemical comparison with other cutaneous appendage tumors. 54 61
1689137 1990
8
Disseminated syringomas of the upper extremities. Case history and immunohistochemical and ultrastructural study. 54 61
1694147 1990
9
An investigation of cytokeratin expression in skin epithelial cysts and some uncommon types of cystic tumours using chain-specific antibodies. 54 61
1701984 1990
10
Benign chondroid syringoma of the orbit: an atypical location. 61
31023118 2020
11
Chondroid syringoma of the axilla masquerading as a metastatic lymph node. 61
32034830 2020
12
Treatment of a case wıth gıant eyelıd syrıngomas. 61
32031106 2020
13
Multiple Scrotal Cysts Composed of Combined Syringomas and Epidermal Inclusion Cysts: A Previously Unreported Association. 61
31361615 2020
14
Ln-γ 2 chain of laminin-332 is a useful marker in differentiating between benign and malignant sclerosing adnexal neoplasms. 61
31429981 2020
15
Next-generation sequencing implicates oncogenic roles for p53 and JAK/STAT signaling in microcystic adnexal carcinomas. 61
31857679 2019
16
Fine-needle aspiration cytology of chondroid syringoma. 61
31576677 2019
17
Giant chondroid syringomas: Review of surgical challenges and treatment approaches, including excision, enucleation and Mohs micrographic surgery. 61
31755087 2019
18
Intralesional Electrocoagulation With Insulated Microneedle for the Treatment of Periorbital Syringomas: A Retrospective Analysis. 61
31630165 2019
19
Bilateral Facial Apocrine Fibrosing Hamartoma Mimicking Microcystic Adnexal Carcinoma. 61
31045870 2019
20
Fusion of the Genes PHF1 and TFE3 in Malignant Chondroid Syringoma. 61
31467228 2019
21
A Rare Forehead Mass: The Chondroid Syringoma. 61
31723522 2019
22
Post Treatment Application of Jaungo after a Combined Therapy of Carbon Dioxide Laser and Trichloroacetic Acid in a Case of Vulvar Syringoma. 61
31673452 2019
23
Plaque-Type Syringoma Masquerading as Microcystic Adnexal Carcinoma: Review of the Literature and Description of a Novel Technique That Emphasizes Lesion Architecture to Help Make the Diagnosis. 61
30921007 2019
24
Dermatoscopy for the rapid diagnosis of Talaromyces marneffei infection: a case report. 61
31399065 2019
25
Tubular apocrine adenoma of the eyelid - A case report and literature review. 61
31686976 2019
26
Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma: Informed by a Systematic Review. 61
31268498 2019
27
Genital Lesions Masquerading as Condyloma Acuminata: A Case Series Report. 61
31341860 2019
28
Chondroid syringoma of the heel masquerading as a malignant tumour: A potential pitfall in diagnosis. 61
31237677 2019
29
Chondroid Syringoma Mimicking Basal Cell Carcinoma. 61
31138414 2019
30
Comparison of microinsulated needle radiofrequency and carbon dioxide laser ablation for the treatment of syringoma. 61
30968519 2019
31
Multiple eruptive syringomas on the penis. 61
31233587 2019
32
Malignant Chondroid Syringoma: A Report of Two Cases with a Sarcomatous Mesenchymal Component. 61
31700847 2019
33
Milia-like idiopathic calcinosis cutis and plaque-type syringoma in a girl with Down syndrome. 61
30194873 2019
34
Differential Expression of PLAG1 in Apocrine and Eccrine Cutaneous Mixed Tumors: Evidence for Distinct Molecular Pathogenesis. 61
30839344 2019
35
Immunoreactivity for Sox10 in Basaloid Neoplasms of The Skin. 61
30531326 2019
36
[Syringomas]. 61
31312306 2019
37
[Palpebral hidrocystoma]. 61
31448032 2019
38
Expression of Potential Dermal Progenitor Cell Markers in the Tumour and Stroma of Skin Adnexal Malignant and Benign Tumours. 61
31065284 2019
39
Malignant Chondroid Syringoma With Nose and Paranasal Sinus Extension: A Case Report. 61
31840006 2019
40
A Case Report of Chondroid Syringoma on the Nose in a Young Male of Middle Eastern Descent. 61
30041541 2019
41
Fine needle aspiration cytology as a preliminary diagnostic tool in chondroid syringoma: a case report and review. 61
31118727 2019
42
Plaque-Type Syringoma Coexisting With Basal Cell Carcinoma. 61
29419541 2018
43
Disseminated Syringomas of the Upper Extremities in a Young Woman. 61
30693166 2018
44
Treatment of giant vulvar syringomas with topical adelmidrol: The role of mast cells. 61
29863277 2018
45
Multiple Acral Syringomas. 61
29361273 2018
46
New trends in botulinum toxin use in dermatology. 61
30479855 2018
47
Dermatological aspects of the S2k guidelines on Down syndrome in childhood and adolescence. 61
30300491 2018
48
Cyto-Histopathological Correlation of Skin Adnexal Tumors: A Short Series. 61
30498290 2018
49
A Case of a Malignant Cutaneous Mixed Tumor (Chondroid Syringoma) of the Scapula Treated With Staged Margin-Controlled Excision. 61
29533281 2018
50
Benign chondroid syringoma affecting the upper lip: Report of a rare case and review of literature. 61
30651687 2018

Variations for Syringoma

Cosmic variations for Syringoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM138385030 skin,face,adnexal tumour,trichoepithelioma c.1318C>T p.Q440* 16:50779853-50779853 8

Expression for Syringoma

Search GEO for disease gene expression data for Syringoma.

Pathways for Syringoma

Pathways related to Syringoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.84 VIM MUC1 KRT7 KRT19 DES
2
Show member pathways
11.47 S100B GFAP ESR1
3 11.23 VIM S100B GFAP
4
Show member pathways
11.05 VIM KRT7 KRT19 GFAP DES

GO Terms for Syringoma

Cellular components related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 9.33 S100A1 KRT19 DES
2 intermediate filament cytoskeleton GO:0045111 9.13 VIM GFAP DES
3 intermediate filament GO:0005882 9.02 VIM KRT7 KRT19 GFAP DES

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 astrocyte development GO:0014002 9.26 GFAP VIM
2 Bergmann glial cell differentiation GO:0060020 9.16 GFAP VIM
3 intermediate filament-based process GO:0045103 8.96 GFAP VIM
4 intermediate filament organization GO:0045109 8.8 VIM GFAP DES

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 VIM S100B S100A1 GFAP ESR1 DES
2 S100 protein binding GO:0044548 9.16 S100B S100A1
3 structural constituent of cytoskeleton GO:0005200 8.92 VIM KRT19 GFAP DES

Sources for Syringoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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