MCID: SYR003
MIFTS: 40

Syringoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Syringoma

MalaCards integrated aliases for Syringoma:

Name: Syringoma 12 53 55 44 15 73
Syringomas 76

Classifications:



External Ids:

Disease Ontology 12 DOID:2065
MeSH 44 D018252
NCIt 50 C3761
SNOMED-CT 68 71244007
UMLS 73 C0206673

Summaries for Syringoma

NIH Rare Diseases : 53 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes, but may also appear elsewhere on the face, in the armpits, umbilicus, upper chest, and genitalia. They arise from the sweat ducts and may occur suddenly in crops or multiples. There are 4 types of syringoma: a localized form, a form associated with Down syndrome, a generalized form that encompases multiple and eruptive syringomas, and a familial form. Syringomas are usually asymptomatic; However, rarely, individuals can experience extreme itching (pruritus), especially while sweating. They are found more commonly in Caucasians, and in females at puberty or near middle-age. Syringomas may be treated surgically using different methods such as high frequency electric current (electrosurgery) or laser.

MalaCards based summary : Syringoma, also known as syringomas, is related to hidradenoma and nodular hidradenoma. An important gene associated with Syringoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and MicroRNAs in cancer. Affiliated tissues include skin, eye and brain, and related phenotypes are behavior/neurological and muscle

Wikipedia : 76 Syringomas are harmless eccrine sweat duct tumors, typically found clustered on eyelids, although they... more...

Related Diseases for Syringoma

Diseases in the Syringoma family:

Syringomas, Multiple Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 hidradenoma 30.4 MUC1 VIM
2 nodular hidradenoma 30.3 MUC1 VIM
3 spiradenoma 30.3 S100B VIM
4 osteochondroma 30.0 S100B VIM
5 syringocystadenoma papilliferum 29.6 DES GFAP MUC1 S100B VIM
6 pleomorphic adenoma 29.4 GFAP MUC1 S100B SERPINB5 TP63 VIM
7 adenoid cystic carcinoma 29.2 MUC1 S100B SERPINB5 TP63 VIM
8 vulvar syringoma 12.2
9 malignant syringoma 12.2
10 syringomas, multiple 12.0
11 chondroid syringoma of the vulva 12.0
12 syringomas natal teeth oligodontia 12.0
13 malignant acrospiroma 11.0
14 down syndrome 10.3
15 calcinosis 10.2
16 adenoma 10.2
17 malignant peritoneal mesothelioma 10.2 MUC1 VIM
18 papillary tumor of the pineal region 10.2 MUC1 VIM
19 secretory meningioma 10.2 MUC1 VIM
20 hydromyelia 10.2 S100B VIM
21 bednar tumor 10.2 S100B VIM
22 diabetes mellitus 10.2
23 bile duct adenoma 10.2 MUC1 VIM
24 localized hypertrophic neuropathy 10.2 MUC1 S100B
25 papillary adenocarcinoma 10.2 MUC1 VIM
26 sclerosing perineurioma 10.2 MUC1 S100B
27 primary hepatic neuroendocrine carcinoma 10.2 S100B VIM
28 adenofibroma 10.2 MUC1 VIM
29 reticular perineurioma 10.2 MUC1 S100B
30 non-functioning pituitary adenoma 10.2 MUC1 S100B
31 functioning pituitary adenoma 10.2 MUC1 S100B
32 sertoli cell tumor 10.2 MUC1 VIM
33 epithelioid malignant peripheral nerve sheath tumor 10.2 MUC1 S100B
34 mucinous cystadenocarcinoma 10.2 MUC1 VIM
35 amelanotic melanoma 10.2 S100B VIM
36 chondroid chordoma 10.2 MUC1 VIM
37 aggressive digital papillary adenocarcinoma 10.2 MUC1 S100B
38 odontogenic myxoma 10.2 S100B VIM
39 glomangiomyoma 10.2 ESR1 VIM
40 papillary ependymoma 10.2 GFAP S100B
41 rhabdoid meningioma 10.2 GFAP VIM
42 basal cell carcinoma 1 10.1
43 alopecia 10.1
44 basal cell carcinoma 10.1
45 pericardial mesothelioma 10.1 MUC1 VIM
46 breast scirrhous carcinoma 10.1 ESR1 MUC1
47 peritoneal mesothelioma 10.1 ESR1 MUC1
48 meningeal melanocytoma 10.1 MUC1 S100B
49 osteofibrous dysplasia 10.1 MUC1 VIM
50 ependymoblastoma 10.1 GFAP VIM

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to Syringoma

Symptoms & Phenotypes for Syringoma

MGI Mouse Phenotypes related to Syringoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 DES ESR1 GFAP S100B SERPINB5 TP63
2 muscle MP:0005369 9.35 DES ESR1 GFAP TP63 VIM
3 normal MP:0002873 9.02 ESR1 GFAP S100B SERPINB5 TP63

Drugs & Therapeutics for Syringoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies Withdrawn NCT00984217 Phase 2 Panitumumab

Search NIH Clinical Center for Syringoma

Cochrane evidence based reviews: syringoma

Genetic Tests for Syringoma

Anatomical Context for Syringoma

MalaCards organs/tissues related to Syringoma:

41
Skin, Eye, Brain, Ovary, Pituitary, Cervix, Smooth Muscle

Publications for Syringoma

Articles related to Syringoma:

(show top 50) (show all 486)
# Title Authors Year
1
Familial eruptive syringoma. ( 29658486 )
2018
2
Chondroid syringoma with extensive cystic change and focal syringometaplasia: A rare histomorphological finding. ( 29567907 )
2018
3
Plaque-Type Syringoma Coexisting With Basal Cell Carcinoma. ( 29419541 )
2018
4
Extensive Eruptive Syringoma After Liver Transplantation. ( 28971206 )
2018
5
Unusual cystic lesion of the eyebrow: A case report of malignant chondroid syringoma. ( 29477759 )
2018
6
A Case of a Malignant Cutaneous Mixed Tumor (Chondroid Syringoma) of the Scapula Treated With Staged Margin-Controlled Excision. ( 29533281 )
2018
7
Erratum: Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology. ( 29898286 )
2018
8
A rare large cutaneous chondroid syringoma involving a toe: A case report. ( 29384887 )
2018
9
Milia-like idiopathic calcinosis cutis and plaque-type syringoma in a girl with Down syndrome. ( 30194873 )
2018
10
A rare case of hyaline cell-rich atypical chondroid syringoma with divergent differentiation. ( 30004073 )
2018
11
A Case Report of Chondroid Syringoma on the Nose in a Young Male of Middle Eastern Descent. ( 30041541 )
2018
12
Multiple Acral Syringomas. ( 29361273 )
2018
13
Vulvar syringomas as a part of nonfamilial generalized eruptive form: Unusual lesions leading to pseudohyper-trophy of the labia majora. ( 29634890 )
2018
14
Treatment of giant vulvar syringomas with topical adelmidrol: The role of mast cells. ( 29863277 )
2018
15
Coexistence of eruptive syringoma and bilateral nipple vitiligo: Could there be a common immunopathogenesis? ( 28971181 )
2017
16
Penile eruptive syringoma. ( 29881510 )
2017
17
Malignant chondroid syringoma of thigh with late metastasis to lung: A very rare case report. ( 28937387 )
2017
18
Chondroid Syringoma of a Cheek. ( 28582289 )
2017
19
Generalized eruptive syringoma with poor clinical response to systemic treatment with acitretin. ( 28177590 )
2017
20
A Case of Eruptive Syringoma Mimicking Plane Warts. ( 28761852 )
2017
21
Chondroid Syringoma: Fine-needle Aspiration Cytology of a Rare Entity at an Unusual Site. ( 28892909 )
2017
22
A case of milium-like syringoma limited to the neck. ( 28449287 )
2017
23
Melanoma in situ and syringoma: a rare collision tumor. Clinical-pathological report of a case. ( 29267461 )
2017
24
Dermoscopy of isolated syringoma of the vulva. ( 28087025 )
2017
25
Case of chondroid syringoma mimicking as nodular hidradenoma: A diagnostic pitfall on cytopathology. ( 28772003 )
2017
26
Plaque-Type Syringoma: A Case Report. ( 29118702 )
2017
27
Coexistence of Adult Onset Eruptive Syringoma and Bilateral Renal Cell Carcinoma: A Case Report. ( 27922891 )
2017
28
Evaluation of Syringomas by In Vivo Reflectance Confocal Microscopy: A Report of Two Cases. ( 27759695 )
2017
29
Acral syringomas associated with hematological neoplasm. ( 27779151 )
2017
30
Eruptive syringomas: unresponsiveness to oral isotretinoin. ( 27805258 )
2017
31
Periorbital Syringomas Treated With an Externally Used 1,444 nm Neodymium-Doped Yttrium Aluminum Garnet Laser. ( 27930372 )
2017
32
Generalized eruptive syringomas. ( 29469728 )
2017
33
Chondroid syringoma of the axilla: An unusual tumor diagnosed by fine needle aspiration. ( 26800260 )
2016
34
Giant Chondroid Syringoma of the Lower Eyelid. ( 27203613 )
2016
35
Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma. ( 27279688 )
2016
36
Chondroid Syringoma on Face. ( 28913278 )
2016
37
An unusual presentation of chondroid syringoma. ( 27510678 )
2016
38
Diagnosis of a rapidly growing preauricular nodule: chondroid syringoma or pleomorphic adenoma? ( 27874890 )
2016
39
Malignant chondroid syringoma in a West African cancer institute: A case report. ( 27372026 )
2016
40
Chondroid Syringoma: A Case Report in the Foot and Ankle. ( 27587378 )
2016
41
Chondroid syringoma invading the distal phalanx of the thumb: a case report. ( 27090725 )
2016
42
Recurrent Chondroid Syringoma of the Alar Rim. ( 28913251 )
2016
43
Chondroid Syringoma of the Hypothenar Region. ( 27403399 )
2016
44
Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis. ( 28035707 )
2016
45
Syringoma: A clinicopathological study of 244 cases. ( 27112697 )
2016
46
Generalized eruptive syringoma: A clinical dilemma. ( 27057500 )
2016
47
A rare association in Down syndrome: milialike idiopathic calcinosis cutis and palpebral syringoma. ( 28099543 )
2016
48
Chondroid syringomas: an immunohistopatological analysis. ( 25922159 )
2016
49
Carbon dioxide laser combined with botulinum toxin A for patients with periorbital syringomas. ( 26073121 )
2016
50
Eruptive Penile Syringomas in an Adolescent: Novel Approach with Serial Microexcisions and Suture-Adhesive Repair. ( 26764082 )
2016

Variations for Syringoma

Cosmic variations for Syringoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM214343 CYLD skin,face,adnexal tumour,trichoepithelioma c.1327C>T p.Q443* 16:50779853-50779853 6
2 COSM476 BRAF skin,abdomen,benign melanocytic nevus,eruptive c.1799T>A p.V600E 7:140753336-140753336 4

Expression for Syringoma

Search GEO for disease gene expression data for Syringoma.

Pathways for Syringoma

GO Terms for Syringoma

Cellular components related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.33 ESR1 MUC1 TP63
2 intermediate filament cytoskeleton GO:0045111 9.26 DES GFAP
3 cytoplasm GO:0005737 9.23 DES ESR1 GFAP MUC1 S100B SERPINB5
4 intermediate filament GO:0005882 9.13 DES GFAP VIM

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-term synaptic potentiation GO:0060291 9.4 GFAP S100B
2 muscle filament sliding GO:0030049 9.37 DES VIM
3 astrocyte development GO:0014002 9.32 GFAP VIM
4 epithelial cell development GO:0002064 9.26 ESR1 TP63
5 Bergmann glial cell differentiation GO:0060020 9.16 GFAP VIM
6 intermediate filament-based process GO:0045103 8.96 GFAP VIM
7 intermediate filament organization GO:0045109 8.8 DES GFAP VIM

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 DES GFAP VIM
2 identical protein binding GO:0042802 9.1 DES ESR1 GFAP S100B TP63 VIM

Sources for Syringoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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