MCID: SYR003
MIFTS: 41

Syringoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Syringoma

MalaCards integrated aliases for Syringoma:

Name: Syringoma 12 54 56 45 15 74
Syringomas 77

Classifications:



External Ids:

Disease Ontology 12 DOID:2065
MeSH 45 D018252
NCIt 51 C3761
SNOMED-CT 69 71244007
UMLS 74 C0206673

Summaries for Syringoma

NIH Rare Diseases : 54 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes, but may also appear elsewhere on the face, in the armpits, umbilicus, upper chest, and genitalia. They arise from the sweat ducts and may occur suddenly in crops or multiples. There are 4 types of syringoma: a localized form, a form associated with Down syndrome, a generalized form that encompases multiple and eruptive syringomas, and a familial form. Syringomas are usually asymptomatic; However, rarely, individuals can experience extreme itching (pruritus), especially while sweating. They are found more commonly in Caucasians, and in females at puberty or near middle-age. Syringomas may be treated surgically using different methods such as high frequency electric current (electrosurgery) or laser.

MalaCards based summary : Syringoma, also known as syringomas, is related to hidradenoma and nodular hidradenoma. An important gene associated with Syringoma is S100B (S100 Calcium Binding Protein B), and among its related pathways/superpathways are Cytoskeletal Signaling and MicroRNAs in cancer. Affiliated tissues include skin, eye and salivary gland, and related phenotypes are behavior/neurological and muscle

Wikipedia : 77 Syringomas are harmless eccrine sweat duct tumors, typically found clustered on eyelids, although they... more...

Related Diseases for Syringoma

Diseases in the Syringoma family:

Syringomas, Multiple Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 hidradenoma 30.6 MUC1 VIM
2 nodular hidradenoma 30.5 MUC1 VIM
3 spiradenoma 30.4 MUC1 S100B
4 osteochondroma 30.1 S100B VIM
5 syringocystadenoma papilliferum 29.4 DES GFAP MUC1 S100B VIM
6 pleomorphic adenoma 28.9 GFAP MUC1 S100B SERPINB5 TP63 VIM
7 adenoid cystic carcinoma 28.9 MUC1 S100B SERPINB5 TP63 VIM
8 vulvar syringoma 12.3
9 malignant syringoma 12.2
10 syringomas, multiple 12.0
11 chondroid syringoma of the vulva 12.0
12 syringomas natal teeth oligodontia 12.0
13 malignant acrospiroma 11.1
14 malignant peritoneal mesothelioma 10.3 MUC1 VIM
15 down syndrome 10.3
16 papillary tumor of the pineal region 10.3 MUC1 VIM
17 secretory meningioma 10.3 MUC1 VIM
18 hydromyelia 10.3 S100B VIM
19 bednar tumor 10.3 S100B VIM
20 papillary adenocarcinoma 10.3 MUC1 VIM
21 localized hypertrophic neuropathy 10.3 MUC1 S100B
22 adenofibroma 10.3 MUC1 VIM
23 sclerosing perineurioma 10.3 MUC1 S100B
24 primary hepatic neuroendocrine carcinoma 10.3 S100B VIM
25 reticular perineurioma 10.3 MUC1 S100B
26 non-functioning pituitary adenoma 10.3 MUC1 S100B
27 functioning pituitary adenoma 10.3 MUC1 S100B
28 sertoli cell tumor 10.3 MUC1 VIM
29 epithelioid malignant peripheral nerve sheath tumor 10.3 MUC1 S100B
30 amelanotic melanoma 10.3 S100B VIM
31 mucinous cystadenocarcinoma 10.3 MUC1 VIM
32 chondroid chordoma 10.3 MUC1 VIM
33 aggressive digital papillary adenocarcinoma 10.3 MUC1 S100B
34 calcinosis 10.3
35 adenoma 10.3
36 odontogenic myxoma 10.2 S100B VIM
37 glomangiomyoma 10.2 ESR1 VIM
38 papillary ependymoma 10.2 GFAP S100B
39 rhabdoid meningioma 10.2 GFAP VIM
40 pericardial mesothelioma 10.2 MUC1 VIM
41 breast scirrhous carcinoma 10.2 ESR1 MUC1
42 peritoneal mesothelioma 10.2 ESR1 MUC1
43 meningeal melanocytoma 10.2 MUC1 S100B
44 diabetes mellitus 10.2
45 osteofibrous dysplasia 10.2 MUC1 VIM
46 ependymoblastoma 10.2 GFAP VIM
47 astroblastoma 10.2 GFAP VIM
48 melanotic neuroectodermal tumor 10.2 GFAP VIM
49 medulloepithelioma 10.2 GFAP VIM
50 epithelioid sarcoma 10.2 MUC1 VIM

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to Syringoma

Symptoms & Phenotypes for Syringoma

MGI Mouse Phenotypes related to Syringoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 DES ESR1 GFAP S100B SERPINB5 TP63
2 muscle MP:0005369 9.35 DES ESR1 GFAP TP63 VIM
3 normal MP:0002873 9.02 ESR1 GFAP S100B SERPINB5 TP63

Drugs & Therapeutics for Syringoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies Withdrawn NCT00984217 Phase 2 Panitumumab

Search NIH Clinical Center for Syringoma

Cochrane evidence based reviews: syringoma

Genetic Tests for Syringoma

Anatomical Context for Syringoma

MalaCards organs/tissues related to Syringoma:

42
Skin, Eye, Salivary Gland, Bone, Lymph Node, Breast, Spinal Cord

Publications for Syringoma

Articles related to Syringoma:

(show top 50) (show all 488)
# Title Authors Year
1
Familial eruptive syringoma. ( 29658486 )
2018
2
Chondroid syringoma with extensive cystic change and focal syringometaplasia: A rare histomorphological finding. ( 29567907 )
2018
3
Plaque-Type Syringoma Coexisting With Basal Cell Carcinoma. ( 29419541 )
2018
4
Extensive Eruptive Syringoma After Liver Transplantation. ( 28971206 )
2018
5
Unusual cystic lesion of the eyebrow: A case report of malignant chondroid syringoma. ( 29477759 )
2018
6
A Case of a Malignant Cutaneous Mixed Tumor (Chondroid Syringoma) of the Scapula Treated With Staged Margin-Controlled Excision. ( 29533281 )
2018
7
Erratum: Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology. ( 29898286 )
2018
8
A rare large cutaneous chondroid syringoma involving a toe: A case report. ( 29384887 )
2018
9
Milia-like idiopathic calcinosis cutis and plaque-type syringoma in a girl with Down syndrome. ( 30194873 )
2018
10
A rare case of hyaline cell-rich atypical chondroid syringoma with divergent differentiation. ( 30004073 )
2018
11
A Case Report of Chondroid Syringoma on the Nose in a Young Male of Middle Eastern Descent. ( 30041541 )
2018
12
Benign chondroid syringoma affecting the upper lip: Report of a rare case and review of literature. ( 30651687 )
2018
13
Multiple Acral Syringomas. ( 29361273 )
2018
14
Vulvar syringomas as a part of nonfamilial generalized eruptive form: Unusual lesions leading to pseudohyper-trophy of the labia majora. ( 29634890 )
2018
15
Treatment of giant vulvar syringomas with topical adelmidrol: The role of mast cells. ( 29863277 )
2018
16
Disseminated Syringomas of the Upper Extremities in a Young Woman. ( 30693166 )
2018
17
Coexistence of eruptive syringoma and bilateral nipple vitiligo: Could there be a common immunopathogenesis? ( 28971181 )
2017
18
Penile eruptive syringoma. ( 29881510 )
2017
19
Malignant chondroid syringoma of thigh with late metastasis to lung: A very rare case report. ( 28937387 )
2017
20
Chondroid Syringoma of a Cheek. ( 28582289 )
2017
21
Generalized eruptive syringoma with poor clinical response to systemic treatment with acitretin. ( 28177590 )
2017
22
A Case of Eruptive Syringoma Mimicking Plane Warts. ( 28761852 )
2017
23
Chondroid Syringoma: Fine-needle Aspiration Cytology of a Rare Entity at an Unusual Site. ( 28892909 )
2017
24
A case of milium-like syringoma limited to the neck. ( 28449287 )
2017
25
Melanoma in situ and syringoma: a rare collision tumor. Clinical-pathological report of a case. ( 29267461 )
2017
26
Dermoscopy of isolated syringoma of the vulva. ( 28087025 )
2017
27
Case of chondroid syringoma mimicking as nodular hidradenoma: A diagnostic pitfall on cytopathology. ( 28772003 )
2017
28
Plaque-Type Syringoma: A Case Report. ( 29118702 )
2017
29
Coexistence of Adult Onset Eruptive Syringoma and Bilateral Renal Cell Carcinoma: A Case Report. ( 27922891 )
2017
30
Evaluation of Syringomas by In Vivo Reflectance Confocal Microscopy: A Report of Two Cases. ( 27759695 )
2017
31
Acral syringomas associated with hematological neoplasm. ( 27779151 )
2017
32
Eruptive syringomas: unresponsiveness to oral isotretinoin. ( 27805258 )
2017
33
Periorbital Syringomas Treated With an Externally Used 1,444 nm Neodymium-Doped Yttrium Aluminum Garnet Laser. ( 27930372 )
2017
34
Generalized eruptive syringomas. ( 29469728 )
2017
35
Chondroid syringoma of the axilla: An unusual tumor diagnosed by fine needle aspiration. ( 26800260 )
2016
36
Giant Chondroid Syringoma of the Lower Eyelid. ( 27203613 )
2016
37
Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma. ( 27279688 )
2016
38
Chondroid Syringoma on Face. ( 28913278 )
2016
39
An unusual presentation of chondroid syringoma. ( 27510678 )
2016
40
Diagnosis of a rapidly growing preauricular nodule: chondroid syringoma or pleomorphic adenoma? ( 27874890 )
2016
41
Malignant chondroid syringoma in a West African cancer institute: A case report. ( 27372026 )
2016
42
Chondroid Syringoma: A Case Report in the Foot and Ankle. ( 27587378 )
2016
43
Chondroid syringoma invading the distal phalanx of the thumb: a case report. ( 27090725 )
2016
44
Recurrent Chondroid Syringoma of the Alar Rim. ( 28913251 )
2016
45
Chondroid Syringoma of the Hypothenar Region. ( 27403399 )
2016
46
Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis. ( 28035707 )
2016
47
Syringoma: A clinicopathological study of 244 cases. ( 27112697 )
2016
48
Generalized eruptive syringoma: A clinical dilemma. ( 27057500 )
2016
49
A rare association in Down syndrome: milialike idiopathic calcinosis cutis and palpebral syringoma. ( 28099543 )
2016
50
Chondroid syringomas: an immunohistopatological analysis. ( 25922159 )
2016

Variations for Syringoma

Cosmic variations for Syringoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM214343 CYLD skin,face,adnexal tumour,trichoepithelioma c.1327C>T p.Q443* 16:50779853-50779853 0
2 COSM476 BRAF skin,abdomen,benign melanocytic nevus,eruptive c.1799T>A p.V600E 7:140753336-140753336 0

Expression for Syringoma

Search GEO for disease gene expression data for Syringoma.

Pathways for Syringoma

GO Terms for Syringoma

Cellular components related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.33 ESR1 MUC1 TP63
2 intermediate filament cytoskeleton GO:0045111 9.26 DES GFAP
3 cytoplasm GO:0005737 9.23 DES ESR1 GFAP MUC1 S100B SERPINB5
4 intermediate filament GO:0005882 9.13 DES GFAP VIM

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-term synaptic potentiation GO:0060291 9.4 GFAP S100B
2 muscle filament sliding GO:0030049 9.37 DES VIM
3 astrocyte development GO:0014002 9.32 GFAP VIM
4 epithelial cell development GO:0002064 9.26 ESR1 TP63
5 Bergmann glial cell differentiation GO:0060020 9.16 GFAP VIM
6 intermediate filament-based process GO:0045103 8.96 GFAP VIM
7 intermediate filament organization GO:0045109 8.8 DES GFAP VIM

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 DES GFAP VIM
2 identical protein binding GO:0042802 9.1 DES ESR1 GFAP S100B TP63 VIM

Sources for Syringoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....