MCID: SYS071
MIFTS: 38

Systemic Autoimmune Disease

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Systemic Autoimmune Disease

MalaCards integrated aliases for Systemic Autoimmune Disease:

Name: Systemic Autoimmune Disease 59

Classifications:



External Ids:

Orphanet 59 ORPHA182228

Summaries for Systemic Autoimmune Disease

MalaCards based summary : Systemic Autoimmune Disease is related to autoimmune disease and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Systemic Autoimmune Disease is RPL7 (Ribosomal Protein L7), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Tuberculosis. The drugs rituximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are immune system and digestive/alimentary

Related Diseases for Systemic Autoimmune Disease

Diseases related to Systemic Autoimmune Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 376)
# Related Disease Score Top Affiliating Genes
1 autoimmune disease 31.1 IL6 IL17A AIRE
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.8 IL17A AIRE
3 autoimmune disease of musculoskeletal system 30.7 IL6 IL17A FCGR2B CRP
4 polyarteritis nodosa 30.6 IL6 CRP
5 adult-onset still's disease 30.3 IL6 CRP
6 pericardial effusion 30.2 IL6 CRP
7 exanthem 30.1 IL6 CRP
8 relapsing polychondritis 30.1 IL6 CRP
9 vascular disease 30.0 MMP9 IL6 CRP
10 temporal arteritis 29.9 IL6 CRP
11 sleep disorder 29.8 IL6 CRP
12 kawasaki disease 29.7 MMP9 IL6 CRP
13 collagen disease 29.7 RPL7 IL6 CRP
14 myelitis 29.6 IL6 IL17A
15 cerebrovascular disease 29.6 MMP9 IL6 CRP
16 neuromyelitis optica 29.6 IL6 IL17A
17 spondylitis 29.6 IL6 IL17A CRP
18 psoriatic arthritis 29.5 IL6 IL17A CRP
19 lung disease 29.5 MMP9 IL6 IL17A
20 bacterial infectious disease 29.4 IL6 IL17A CRP
21 coronary stenosis 29.4 IL6 CRP
22 spondyloarthropathy 29.4 IL6 IL17A
23 inflammatory bowel disease 29.4 IL6 IL17A CRP
24 behcet syndrome 29.1 IL6 IL17A CRP
25 keratitis, hereditary 29.0 MMP9 IL17A
26 bronchiolitis 29.0 IL6 IL17A CRP
27 ulcerative colitis 28.9 IL6 IL17A CRP
28 bronchiolitis obliterans 28.9 MMP9 IL6 IL17A
29 arthritis 28.8 MMP9 IL6 IL17A
30 rheumatoid arthritis 28.8 MMP9 IL6 IL17A CRP
31 multiple sclerosis 28.5 MMP9 IL6 IL17A
32 periodontitis 28.2 MMP9 IL6 IL17A CRP
33 pulmonary disease, chronic obstructive 28.2 MMP9 IL6 IL17A CRP
34 systemic lupus erythematosus 28.1 RPL7 IL6 IL17A FCGR3A FCGR2B CRP
35 sjogren syndrome 11.5
36 celiac disease 1 11.3
37 autoimmune disease of central nervous system 11.3
38 autoimmune disease of endocrine system 11.3
39 autoimmune disease of peripheral nervous system 11.3
40 autoimmune disease of cardiovascular system 11.3
41 vogt-koyanagi-harada disease 11.0
42 vasculitis 10.5
43 scleroderma, familial progressive 10.5
44 connective tissue disease 10.4
45 antiphospholipid syndrome 10.4
46 cold agglutinin disease 10.4 IL6 CRP
47 cryopyrin-associated periodic syndrome 10.4 IL6 CRP
48 systemic scleroderma 10.4
49 acute cholangitis 10.4 IL6 CRP
50 uremic pruritus 10.4 IL6 CRP

Graphical network of the top 20 diseases related to Systemic Autoimmune Disease:



Diseases related to Systemic Autoimmune Disease

Symptoms & Phenotypes for Systemic Autoimmune Disease

MGI Mouse Phenotypes related to Systemic Autoimmune Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 AIRE CRP FCGR2B IL17A IL6 MAN2A1
2 digestive/alimentary MP:0005381 9.65 AIRE FCGR2B IL17A IL6 MMP9
3 renal/urinary system MP:0005367 9.35 FCGR2B IL17A IL6 MAN2A1 MMP9
4 respiratory system MP:0005388 9.1 AIRE FCGR2B IL17A IL6 MAN2A1 MMP9

Drugs & Therapeutics for Systemic Autoimmune Disease

Drugs for Systemic Autoimmune Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 116)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 4 174722-31-7 10201696
2 Antineoplastic Agents, Immunological Phase 4
3
Hydroxychloroquine Approved Phase 3 118-42-3 3652
4
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
5
Acetaminophen Approved Phase 3 103-90-2 1983
6
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
7
Clemastine Approved, Investigational Phase 3 15686-51-8 26987
8
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
9
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
10
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
12
Abatacept Approved Phase 3 332348-12-6 10237
13 Coconut Approved Phase 3
14
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 6221 5280795
15
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
16
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
17
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
18
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
19 Antiparasitic Agents Phase 3
20 Antimalarials Phase 3
21 Antiprotozoal Agents Phase 3
22 Antibodies Phase 3
23 Immunoglobulins Phase 3
24 Hormone Antagonists Phase 3
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
26 Alkylating Agents Phase 3
27 Antineoplastic Agents, Alkylating Phase 3
28 Gastrointestinal Agents Phase 3
29 Antiemetics Phase 3
30 Neuroprotective Agents Phase 3
31 glucocorticoids Phase 3
32 Peripheral Nervous System Agents Phase 3
33 Anti-Inflammatory Agents Phase 3
34 Methylprednisolone Acetate Phase 3
35 Antibodies, Antineutrophil Cytoplasmic Phase 3
36 Protective Agents Phase 3
37 Antineoplastic Agents, Hormonal Phase 3
38 Autonomic Agents Phase 3
39 Prednisolone acetate Phase 3
40 Antirheumatic Agents Phase 3
41 Immunologic Factors Phase 3
42 Immunosuppressive Agents Phase 3
43 Hormones Phase 3
44 Micronutrients Phase 3
45 Trace Elements Phase 3
46 Vitamins Phase 3
47 Vitamin D2 Phase 3
48 Nutrients Phase 3
49 Ergocalciferols Phase 3
50 Calciferol Phase 3

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Abatacept for the Treatment of Refractory Juvenile Dermatomyositis Recruiting NCT02594735 Phase 4 Abatacept
2 Maintenance of ANCA Vasculitis Remission by Intermittent Rituximab Dosing Based on B-cell Reconstitution vs a Serologic ANCA Flare Recruiting NCT02749292 Phase 4 Rituximab
3 Randomized, Double-blind, Placebo-controlled Trial of Hydroxychloroquine in Primary Sjögren's Syndrome Completed NCT00632866 Phase 3 Hydroxychloroquine;Placebo
4 A Randomized, Double-blind, Parallel, Placebo-controlled Trial to Evaluate the Efficacy of Tocilizumab for the Treatment of Primary Sjögren's Syndrome. Completed NCT01782235 Phase 2, Phase 3 Tocilizumab;Placebo
5 Evaluating Favorable, Immunological Effects of Rituximab With Cyclophosphamide Compared to Rituximab Alone in AAV Patients Recruiting NCT03942887 Phase 3 Rituximab;endoxan;Methylprednisolone;Prednisolone
6 Randomized, Double-blind, Placebo-controlled Phase III Study to Assess the Efficacy and Safety of Abatacept in Patients With Primary Sjögren's Syndrome (ASAP III Study = Abatacept Sjögren Active Patients Phase III Study) Active, not recruiting NCT02067910 Phase 3 Abatacept SC
7 Vitamin D3 Supplementation in Polymorphic Light Eruption: Randomized Double-blinded Placebo-controlled Trial Terminated NCT01595893 Phase 3 Oral Vitamin D 3;Miglyol 812 N
8 A Phase 2, Proof of Concept, 52-Week Open Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006, LymphoStat-B™), a Fully Human Monoclonal Anti-BLyS (BAFF) Antibody, in Subjects With Primary Sjögren's Syndrome Completed NCT01160666 Phase 2 Belimumab
9 Pilot Study Related to the Effect of Clopidogrel on Plasmatic Soluble CD40 Ligand During Systemic Lupus Erythematous Completed NCT02320357 Phase 1, Phase 2 Treatment by clopidogrel
10 A Phase II, Randomised, Double-blind, International, Multicentre, Placebo-controlled, Dose-ranging, Parallel-group Study to Evaluate the Efficacy and Safety of Orally Administered Rob 803 When Added to Stable Methotrexate Completed NCT00525213 Phase 2 Rob 803;Placebo
11 A Phase 2, Proof of Concept, 52-Week Open Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006, LymphoStat-B™), a Fully Human Monoclonal Anti-BLyS Antibody, in Subjects With Primary Sjögren's Syndrome. Completed NCT01008982 Phase 2 LimphoStat-B
12 Pilot Study of Thalidomide for Sjogren's Syndrome Completed NCT00001599 Phase 2 Thalidomide
13 A Pilot Study of Intensified Lymphodepletion Followed by Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Systemic Lupus Erythematosus Completed NCT00076752 Phase 2 fludarabine phosphate;cyclophosphamide;methylprednisolone;Diphenhydramine;Mesna
14 A Randomized Trial to Investigate the Reset of Humoral Autoimmunity by Combining Belimumab With Rituximab in Severe Systemic Lupus Erythematosus Recruiting NCT03747159 Phase 2 Belimumab Injection
15 Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, ALT-803 and Epacadostat (QuEST1) Recruiting NCT03493945 Phase 1, Phase 2 ALT-803;Epacadostat
16 A Randomized Placebo-controlled, Double Blind Phase 2 Clinical Trial of Levocarnitine for the Treatment of Keratoconjunctivitis Sicca in Sjogren's Syndrome Not yet recruiting NCT03953703 Phase 2 Levocarnitine;Placebo
17 A Phase I/II Study of Nonmyeloablative Conditioning and Transplantation of Human Leukocyte Antigen (HLA)-Matched, Partially HLA-mismatched, HLA-haploidentical or Matched Unrelated Bone Marrow for Patients With Refractory SLE Terminated NCT02080195 Phase 1, Phase 2 Cyclophosphamide;Fludarabine;Tacrolimus;Mycophenolate Mofetil;Rabbit antithymocyte globulin
18 Abatacept for Patients With Inflammatory Arthritis Associated With Sjögren's Syndrome: an Open-Label Phase II Study Withdrawn NCT02027298 Phase 2 Abatacept
19 An Open Label Phase I Study to Evaluate the Safety and Tolerability of GI-6301 Vaccine Consisting of Whole, Heat-Killed Recombinant Saccharomyces Cerevisiae (Yeast) Genetically Modified to Express Brachyury Protein in Adults With Solid Tumors Completed NCT01519817 Phase 1
20 First In-Human Phase I Trial of NHS-IL12 in Patients With Metastatic Solid Tumors Recruiting NCT01417546 Phase 1 NHS-IL-12
21 Diagnostic Value of Antibodies Against a Modified Citrullinated Vimentin in Patients With Rheumatoid Arthritis Unknown status NCT03265236
22 Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases: Inception Cohort Unknown status NCT02890134
23 Role of DcR3 in T Cell Activation in SLE and RA Unknown status NCT00275899
24 Study of the Role of Soluble Forms of RAGE (sRAGE/esRAGE) as Diagnostic and Prognostic Biomarkers of Systemic Lupus Erythematosus. Unknown status NCT02891213
25 The Effect of Ethanol Extract Physalis Angulata Linn. in Scleroderma Patients With Standard Therapy to Reduce Skin Fibrosis Based on Modified Rodnan Skin Score, Reduce Inflammation, Immunological Response and Fibrosis Completed NCT03141125
26 Effect of Qi Gong Training on Quality of Life in Patients With Systemic Lupus Erythematous (LuQi) Completed NCT02732470
27 Study During Pregnancy of miRNAs in Rheumatoid Arthritis or Systemic Lupus Erythematosus Completed NCT02350491
28 Patient Interviews to Better Understand Disease Experience and Unmet Treatment Needs in Rheumatoid Arthritis Completed NCT03285191
29 Exercise-induced Improvements of Inflammatory Status in Patients With Rheumatoid Arthritis - Improvements of Cardiovascular Risk Factors and Quality of Life Completed NCT01478334
30 Systemic Lupus Erythematosus in Gullah Health Recruiting NCT00756769
31 Risk Factors for Thrombosis in Immune Thrombocytopenia Recruiting NCT03820960
32 The Colonic Microbiome and Mucosal Immunity in Inflammatory Bowel Disease and Ankylosing Spondylitis Recruiting NCT02389075
33 Duke Lupus Registry Recruiting NCT00512694
34 The DRAIHA Study: Data Registry of AutoImmune Hemolytic Anemia, to Improve Diagnostic Testing for the Development of Personalized Treatment Protocols in AIHA Patients Recruiting NCT04024202
35 Assessment of Systemic Complications (Signs) and Evolution From Patients With Sjögren's Syndrome (ASSESS) Recruiting NCT03040583
36 Dietary Phytoestrogens in Blood and Urine of Female Patient With Acute Systemic Lupus Erythematosus Recruiting NCT03421184
37 Department of Nursing, Dalin Tzuchi Hospital Recruiting NCT03446989
38 Duke Autoimmunity in Pregnancy Registry Active, not recruiting NCT00513591
39 Chemokine CXCL13 as a Marker of Disease Activity in Systemic Lupus Erythematosus Not yet recruiting NCT03752983
40 Autophagy Genes and Interleukin-10 in Systemic Lupus Erythematosus Patients Not yet recruiting NCT03583853
41 Ocular Comorbidities of Alopecia Areata Not yet recruiting NCT03155958
42 Involvement of Immune Cells Derived From the Intestine in Sjogren's Syndrome Not yet recruiting NCT03841318
43 Finger-prick Autologous Blood (FAB) for Use in Dry Mouth Not yet recruiting NCT03530735

Search NIH Clinical Center for Systemic Autoimmune Disease

Genetic Tests for Systemic Autoimmune Disease

Anatomical Context for Systemic Autoimmune Disease

MalaCards organs/tissues related to Systemic Autoimmune Disease:

41
T Cells, B Cells, Bone, Skin, Bone Marrow, Salivary Gland, Lung

Publications for Systemic Autoimmune Disease

Articles related to Systemic Autoimmune Disease:

(show top 50) (show all 1471)
# Title Authors PMID Year
1
Current mechanistic insights into the role of infection in systemic lupus erythematosus. 38
31226637 2019
2
A novel de novo MTOR gain-of-function variant in a patient with Smith-Kingsmore syndrome and Antiphospholipid syndrome. 38
31053780 2019
3
SERS-based liquid biopsy of saliva and serum from patients with Sjögren's syndrome. 38
31214753 2019
4
Association of Epstein-Barr virus serological reactivation with transitioning to systemic lupus erythematosus in at-risk individuals. 38
31217170 2019
5
Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis. 38
31371305 2019
6
Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking "Inflammaging" in Patients with Systemic Lupus Erythematosus. 38
31395799 2019
7
IgG4-related sialadenitis complicated with type III mixed cryoglobulinemia: A case report. 38
31374024 2019
8
Should Generalized Immunosuppression or Targeted Organ Treatment be the Best Principle for Overall Management of Systemic Lupus Erythematosus? 38
31277750 2019
9
An update on the genetics of systemic lupus erythematosus. 38
31436585 2019
10
Epigenetic perspectives on systemic autoimmune disease. 38
31421964 2019
11
Altered Tregs and oxidative stress in pregnancy associated lupus. 38
31412940 2019
12
Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification. 38
31431317 2019
13
Increased risks of psychiatric disorders in patients with primary Sjögren's syndrome-a secondary cohort analysis of nationwide, population-based health claim data. 38
31372849 2019
14
Hematologic Manifestations in Celiac Disease-A Practical Review. 38
31311098 2019
15
Primary antiphospholipid syndrome in a hemodialysis patient with recurrent thrombosis of arteriovenous fistulas. 38
31419276 2019
16
Glucocorticoid-Sensitive Paroxysmal Atrial Fibrillation, Sick Sinus Syndrome, and Mitral Regurgitation in a Patient with Malignant Rheumatoid Vasculitis. 38
31292399 2019
17
A Case of Systemic Lupus Erythematosus Presenting as Autoimmune Myelofibrosis. 38
31257359 2019
18
Overexpression of Smac is associated with the development of primary Sjogren's syndrome. 38
31305346 2019
19
Prognostic markers of lymphoma development in primary Sjögren syndrome. 38
31215845 2019
20
Overexpression of Smac is associated with the development of primary Sjogren's syndrome. 38
31274785 2019
21
Visfatin as a therapeutic target for rheumatoid arthritis. 38
31074669 2019
22
Mavrilimumab: a unique insight and update on the current status in the treatment of rheumatoid arthritis. 38
31208237 2019
23
Metabolic syndrome and systemic lupus erythematosus: the connection. 38
31094570 2019
24
Berunda Polypeptides: Biheaded Rapamycin Carriers for Subcutaneous Treatment of Autoimmune Dry Eye Disease. 38
31095909 2019
25
Clinical Characteristics and Outcomes of Ocular Cicatricial Pemphigoid: A Cohort Study and Literature Review. 38
31356420 2019
26
Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice. 38
31022494 2019
27
Management of maternal antiphospholipid syndrome. 38
31287415 2019
28
Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation. 38
31019063 2019
29
Antibody modified gold nanoparticles for fast colorimetric screening of rheumatoid arthritis. 38
31070614 2019
30
Evans Syndrome with Acute Kidney Injury. 38
31356100 2019
31
Ocular Manifestations of Granulomatosis with Polyangiitis: A Review of the Literature. 38
30875067 2019
32
Eosinophilic granulomatosis with polyangiitis in a Nigerian woman. 38
31217209 2019
33
Current Therapeutic Options in the Treatment of Rheumatoid Arthritis. 38
31261785 2019
34
The genetic pathogenesis, diagnosis and therapeutic insight of rheumatoid arthritis. 38
30578544 2019
35
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus. 38
31101814 2019
36
Histopathological evaluation of scleritis. 38
30723093 2019
37
Association of Dendritic Cell Signatures With Autoimmune Inflammation Revealed by Single-Cell Profiling. 38
30511817 2019
38
Psychological affection in rheumatoid arthritis patients in relation to disease activity. 38
31083165 2019
39
Clinical Characteristics of Bilateral Meniere's Disease in a Single Asian Ethnic Group. 38
30284277 2019
40
Identification of differentially expressed genes in primary Sjögren's syndrome. 38
31125139 2019
41
Silicone breast implants and depression, fibromyalgia and chronic fatigue syndrome in a rheumatology clinic population. 38
30706290 2019
42
Ten-year observation of patients with primary Sjögren's syndrome: Initial presenting characteristics and the associated outcomes. 38
30588773 2019
43
Racial Disparities in Mortality Associated with Systemic Lupus Erythematosus - Fulton and DeKalb Counties, Georgia, 2002-2016. 38
31071073 2019
44
Investigation of gene expression profiles in a rat adjuvant arthritis model suggests an effective role of triptolide via PI3K-AKT signaling. 38
30988781 2019
45
The diagnostic accuracies of the 2012 SLICC criteria and the proposed EULAR/ACR criteria for systemic lupus erythematosus classification are comparable. 38
31046572 2019
46
Positive effect of ozonotherapy on serum concentration of soluble interleukin-2 receptor and neopterin in patients with systemic sclerosis. 38
31320847 2019
47
CR6-interacting factor 1 controls autoimmune arthritis by regulation of signal transducer and activator of transcription 3 pathway and T helper type 17 cells. 38
30585643 2019
48
The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity. 38
30996136 2019
49
Feature Article: Altered morpho-functional features of bones in autoimmune disease-prone BXSB/MpJ- Yaa mice. 38
30818998 2019
50
Mast Cells in Early Rheumatoid Arthritis. 38
31027208 2019

Variations for Systemic Autoimmune Disease

Copy number variations for Systemic Autoimmune Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 21054 1 156500000 165500000 Duplication FCGR3B Systemic autoimmune disease

Expression for Systemic Autoimmune Disease

Search GEO for disease gene expression data for Systemic Autoimmune Disease.

Pathways for Systemic Autoimmune Disease

GO Terms for Systemic Autoimmune Disease

Biological processes related to Systemic Autoimmune Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.5 MMP9 IL6 IL17A
2 inflammatory response GO:0006954 9.46 IL6 IL17A FCGR2B CRP
3 acute-phase response GO:0006953 9.26 IL6 CRP
4 immune response GO:0006955 9.02 IL6 IL17A FCGR3A FCGR2B AIRE
5 negative regulation of lipid storage GO:0010888 8.96 IL6 CRP

Molecular functions related to Systemic Autoimmune Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 8.62 FCGR3A FCGR2B

Sources for Systemic Autoimmune Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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