Systemic Autoimmune Disease

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Systemic Autoimmune Disease

MalaCards integrated aliases for Systemic Autoimmune Disease:

Name: Systemic Autoimmune Disease 58


Orphanet: 58  
Rare systemic and rhumatological diseases

External Ids:

Orphanet 58 ORPHA182228

Summaries for Systemic Autoimmune Disease

MalaCards based summary : Systemic Autoimmune Disease is related to autoimmune disease of cardiovascular system and autoimmune disease of peripheral nervous system. An important gene associated with Systemic Autoimmune Disease is RPL7 (Ribosomal Protein L7), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Tuberculosis. The drugs Abatacept and rituximab have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are immune system and digestive/alimentary

Related Diseases for Systemic Autoimmune Disease

Diseases related to Systemic Autoimmune Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 482)
# Related Disease Score Top Affiliating Genes
1 autoimmune disease of cardiovascular system 31.9 IL6 CRP
2 autoimmune disease of peripheral nervous system 31.6 IL6 IL17A
3 autoimmune disease of endocrine system 31.5 IL6 IL17A AIRE
4 autoimmune disease of exocrine system 31.4 IL6 IL17A CRP
5 autoimmune disease of musculoskeletal system 31.4 IL6 IL17A CRP
6 celiac disease 1 31.1 IL6 IL17A CRP AIRE
7 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.8 IL17A AIRE
8 juvenile arthritis 30.3 IL6 CRP
9 vasculitis 30.2 IL6 IL17A CRP
10 pneumocystosis 30.1 IL6 CRP
11 systemic scleroderma 30.0 IL6 IL17A CRP
12 scleritis 29.9 MMP9 CRP
13 pyuria 29.8 IL6 CRP
14 acute transverse myelitis 29.8 MMP9 IL6
15 atherosclerosis susceptibility 29.7 MMP9 IL6 CRP
16 parotitis 29.7 MMP9 CRP
17 cryptogenic organizing pneumonia 29.7 MMP9 CRP
18 spondylitis 29.6 IL6 IL17A CRP
19 psoriatic arthritis 29.5 IL6 IL17A CRP
20 neuromyelitis optica 29.4 IL6 IL17A CRP
21 cerebrovascular disease 29.4 MMP9 IL6 CRP
22 demyelinating disease 29.3 MMP9 IL6 IL17A
23 temporal arteritis 29.3 IL6 IL17A CRP
24 chorioamnionitis 29.3 MMP9 IL6 CRP
25 aortic aneurysm 29.3 MMP9 IL6 CRP
26 iridocyclitis 29.2 IL6 IL17A CRP
27 cystitis 29.1 IL6 IL17A CRP
28 myelitis 29.1 MMP9 IL6 IL17A
29 lung disease 29.1 MMP9 IL6 IL17A CRP
30 cholangitis, primary sclerosing 29.1 IL6 IL17A AIRE
31 candidiasis 29.0 IL6 IL17A AIRE
32 alopecia areata 29.0 IL6 IL17A AIRE
33 hashimoto thyroiditis 29.0 IL6 IL17A AIRE
34 bronchiolitis 29.0 IL6 IL17A CRP
35 peripheral nervous system disease 29.0 IL6 IL17A CRP
36 relapsing polychondritis 29.0 IL6 IL17A CRP
37 aspiration pneumonia 29.0 IL6 IL17A CRP
38 interstitial lung disease 29.0 MMP9 IL6 IL17A CRP
39 panuveitis 29.0 IL6 IL17A CRP
40 neutropenia 29.0 IL6 FCGR3A CRP
41 endocarditis 29.0 IL6 IL17A CRP
42 cholangitis 28.9 IL6 IL17A CRP
43 transverse myelitis 28.9 MMP9 IL6 IL17A
44 crohn's disease 28.9 IL6 IL17A CRP
45 ulcerative colitis 28.8 IL6 IL17A CRP
46 spondyloarthropathy 28.8 IL6 IL17A FCGR3A
47 pneumonia 28.7 MMP9 IL6 IL17A CRP
48 bacterial infectious disease 28.7 IL6 IL17A FCGR3A CRP
49 eye disease 28.5 MMP9 IL6 IL17A CRP
50 behcet syndrome 28.5 IL6 IL17A FCGR3A CRP

Graphical network of the top 20 diseases related to Systemic Autoimmune Disease:

Diseases related to Systemic Autoimmune Disease

Symptoms & Phenotypes for Systemic Autoimmune Disease

MGI Mouse Phenotypes related to Systemic Autoimmune Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 AIRE CRP FCGR2B IL17A IL6 MAN2A1
2 digestive/alimentary MP:0005381 9.65 AIRE FCGR2B IL17A IL6 MMP9
3 renal/urinary system MP:0005367 9.35 FCGR2B IL17A IL6 MAN2A1 MMP9
4 respiratory system MP:0005388 9.1 AIRE FCGR2B IL17A IL6 MAN2A1 MMP9

Drugs & Therapeutics for Systemic Autoimmune Disease

Drugs for Systemic Autoimmune Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Abatacept Approved Phase 4 332348-12-6 10237
rituximab Approved Phase 4 174722-31-7 10201696
3 Antirheumatic Agents Phase 4
4 Immunosuppressive Agents Phase 4
5 Immunologic Factors Phase 4
6 Antineoplastic Agents, Immunological Phase 4
Hydroxychloroquine Approved Phase 3 118-42-3 3652
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
Clemastine Approved, Investigational Phase 3 15686-51-8 26987
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
Acetaminophen Approved Phase 3 103-90-2 1983
14 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
17 Coconut Approved Phase 3
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 5280795 6221
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
21 Antiprotozoal Agents Phase 3
22 Antiparasitic Agents Phase 3
23 Antimalarials Phase 3
24 Immunoglobulins Phase 3
25 Antibodies Phase 3
26 Alkylating Agents Phase 3
27 Antineoplastic Agents, Hormonal Phase 3
28 Methylprednisolone Acetate Phase 3
29 Hormone Antagonists Phase 3
30 glucocorticoids Phase 3
31 Neuroprotective Agents Phase 3
32 Antiemetics Phase 3
33 Protective Agents Phase 3
34 Gastrointestinal Agents Phase 3
35 Anti-Inflammatory Agents Phase 3
36 Trace Elements Phase 3
37 Micronutrients Phase 3
38 Vitamins Phase 3
39 Hormones Phase 3
40 Nutrients Phase 3
41 Calcium, Dietary Phase 3
42 Calciferol Phase 3
Calcium Nutraceutical Phase 3 7440-70-2 271
Clopidogrel Approved Phase 1, Phase 2 113665-84-2, 120202-66-6 60606
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
Mesna Approved, Investigational Phase 2 3375-50-6 598
Promethazine Approved, Investigational Phase 2 60-87-7 4927
Histamine Approved, Investigational Phase 2 51-45-6 774
Lenograstim Approved, Investigational Phase 2 135968-09-1
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Abatacept for the Treatment of Refractory Juvenile Dermatomyositis Recruiting NCT02594735 Phase 4 Abatacept
2 Maintenance of ANCA Vasculitis Remission by Intermittent Rituximab Dosing Based on B-cell Reconstitution vs a Serologic ANCA Flare Recruiting NCT02749292 Phase 4 Rituximab
3 Randomized, Double-blind, Placebo-controlled Trial of Hydroxychloroquine in Primary Sjögren's Syndrome Completed NCT00632866 Phase 3 Hydroxychloroquine;Placebo
4 A Randomized, Double-blind, Parallel, Placebo-controlled Trial to Evaluate the Efficacy of Tocilizumab for the Treatment of Primary Sjögren's Syndrome. Completed NCT01782235 Phase 2, Phase 3 Tocilizumab;Placebo
5 Randomized, Double-blind, Placebo-controlled Phase III Study to Assess the Efficacy and Safety of Abatacept in Patients With Primary Sjögren's Syndrome (ASAP III Study = Abatacept Sjögren Active Patients Phase III Study) Completed NCT02067910 Phase 3 Abatacept SC
6 Evaluating Favorable, Immunological Effects of Rituximab With Cyclophosphamide Compared to Rituximab Alone in AAV Patients Recruiting NCT03942887 Phase 3 Rituximab;endoxan;Methylprednisolone;Prednisolone
7 Vitamin D3 Supplementation in Polymorphic Light Eruption: Randomized Double-blinded Placebo-controlled Trial Terminated NCT01595893 Phase 3 Oral Vitamin D 3;Miglyol 812 N
8 A Phase 2, Proof of Concept, 52-Week Open Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006, LymphoStat-B™), a Fully Human Monoclonal Anti-BLyS (BAFF) Antibody, in Subjects With Primary Sjögren's Syndrome Completed NCT01160666 Phase 2 Belimumab
9 Pilot Study Related to the Effect of Clopidogrel on Plasmatic Soluble CD40 Ligand During Systemic Lupus Erythematous Completed NCT02320357 Phase 1, Phase 2 Treatment by clopidogrel
10 A Phase II, Randomised, Double-blind, International, Multicentre, Placebo-controlled, Dose-ranging, Parallel-group Study to Evaluate the Efficacy and Safety of Orally Administered Rob 803 When Added to Stable Methotrexate Completed NCT00525213 Phase 2 Rob 803;Placebo
11 A Phase 2, Proof of Concept, 52-Week Open Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006, LymphoStat-B™), a Fully Human Monoclonal Anti-BLyS Antibody, in Subjects With Primary Sjögren's Syndrome. Completed NCT01008982 Phase 2 LimphoStat-B
12 Pilot Study of Thalidomide for Sjogren's Syndrome Completed NCT00001599 Phase 2 Thalidomide
13 A Pilot Study of Intensified Lymphodepletion Followed by Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Systemic Lupus Erythematosus Completed NCT00076752 Phase 2 fludarabine phosphate;cyclophosphamide;methylprednisolone;Diphenhydramine;Mesna
14 A Randomized Trial to Investigate the Reset of Humoral Autoimmunity by Combining Belimumab With Rituximab in Severe Systemic Lupus Erythematosus Recruiting NCT03747159 Phase 2 Belimumab Injection
15 A Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, ALT-803 and Epacadostat (QuEST1) Recruiting NCT03493945 Phase 1, Phase 2 ALT-803;Epacadostat
16 A Randomized Placebo-controlled, Double Blind Pilot Crossover Trial of Levocarnitine for the Treatment of Keratoconjunctivitis Sicca in Sjogren's Syndrome Not yet recruiting NCT03953703 Phase 2 Levocarnitine;Placebo
17 Subcutaneous Injections of Autologous Cultured Adipose-derived Stroma/ Stem Cells to Heal Refractory Ischemic Digital Ulcers in Patients With Scleroderma Not yet recruiting NCT04356755 Phase 2 Autologous ASC;Placebo
18 A Phase I/II Study of Nonmyeloablative Conditioning and Transplantation of Human Leukocyte Antigen (HLA)-Matched, Partially HLA-mismatched, HLA-haploidentical or Matched Unrelated Bone Marrow for Patients With Refractory SLE Terminated NCT02080195 Phase 1, Phase 2 Cyclophosphamide;Fludarabine;Tacrolimus;Mycophenolate Mofetil;Rabbit antithymocyte globulin
19 Abatacept for Patients With Inflammatory Arthritis Associated With Sjögren's Syndrome: an Open-Label Phase II Study Withdrawn NCT02027298 Phase 2 Abatacept
20 An Open Label Phase I Study to Evaluate the Safety and Tolerability of GI-6301 Vaccine Consisting of Whole, Heat-Killed Recombinant Saccharomyces Cerevisiae (Yeast) Genetically Modified to Express Brachyury Protein in Adults With Solid Tumors Completed NCT01519817 Phase 1
21 First In-Human Phase I Trial of NHS-IL12 in Patients With Metastatic Solid Tumors Recruiting NCT01417546 Phase 1 NHS-IL-12
22 Ocular Comorbidities of Alopecia Areata Unknown status NCT03155958
23 Diagnostic Value of Antibodies Against a Modified Citrullinated Vimentin in Patients With Rheumatoid Arthritis Unknown status NCT03265236
24 Role of DcR3 in T Cell Activation in SLE and RA Unknown status NCT00275899
25 Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases: Inception Cohort Unknown status NCT02890134
26 Department of Nursing, Dalin Tzuchi Hospital Unknown status NCT03446989
27 Finger-prick Autologous Blood (FAB) for Use in Dry Mouth Unknown status NCT03530735
28 Study of the Role of Soluble Forms of RAGE (sRAGE/esRAGE) as Diagnostic and Prognostic Biomarkers of Systemic Lupus Erythematosus. Unknown status NCT02891213
29 Investigation of the Relationship Between the Pelvic Floor and Sexual Dysfunction in Women With Sjogren's Syndrome Completed NCT04415710
30 Duke Autoimmunity in Pregnancy Registry Completed NCT00513591
31 The Effect of Ethanol Extract Physalis Angulata Linn. in Scleroderma Patients With Standard Therapy to Reduce Skin Fibrosis Based on Modified Rodnan Skin Score, Reduce Inflammation, Immunological Response and Fibrosis Completed NCT03141125
32 Effect of Qi Gong Training on Quality of Life in Patients With Systemic Lupus Erythematous (LuQi) Completed NCT02732470
33 Study During Pregnancy of miRNAs in Rheumatoid Arthritis or Systemic Lupus Erythematosus Completed NCT02350491
34 Patient Interviews to Better Understand Disease Experience and Unmet Treatment Needs in Rheumatoid Arthritis Completed NCT03285191
35 Exercise-induced Improvements of Inflammatory Status in Patients With Rheumatoid Arthritis - Improvements of Cardiovascular Risk Factors and Quality of Life Completed NCT01478334
36 Systemic Lupus Erythematosus in Gullah Health Recruiting NCT00756769
37 Duke Lupus Registry Recruiting NCT00512694
38 Risk Factors for Thrombosis in Immune Thrombocytopenia Recruiting NCT03820960
39 Dietary Phytoestrogens in Blood and Urine of Female Patient With Acute Systemic Lupus Erythematosus Recruiting NCT03421184
40 The DRAIHA Study: Data Registry of AutoImmune Hemolytic Anemia, to Improve Diagnostic Testing for the Development of Personalized Treatment Protocols in AIHA Patients Recruiting NCT04024202
41 Assessment of Systemic Complications (Signs) and Evolution From Patients With Sjögren's Syndrome (ASSESS) Recruiting NCT03040583
42 The Colonic Microbiome and Mucosal Immunity in Inflammatory Bowel Disease and Ankylosing Spondylitis Enrolling by invitation NCT02389075
43 Contribution of 7.0 Tesla RMI in Screening of Osteoarticular Involvement and Vasculopathy of the Hands in Systemic Sclerosis Not yet recruiting NCT04223817
44 Chemokine CXCL13 as a Marker of Disease Activity in Systemic Lupus Erythematosus Not yet recruiting NCT03752983
45 Plasmacytoid Dendritic Cells and Toll Like Receptor 8 in Systemic Sclerosis Not yet recruiting NCT04303208
46 Autophagy Genes and Interleukin-10 in Systemic Lupus Erythematosus Patients Not yet recruiting NCT03583853
47 Involvement of Immune Cells Derived From the Intestine in Sjogren's Syndrome Not yet recruiting NCT03841318
48 Urinary Tissue Factor (TF), Tissue Factor Pathway Inhibitor (TFPI) and Plasmin as Bio-markers in Early Diagnosis of Lupus Nephritis Not yet recruiting NCT04218890

Search NIH Clinical Center for Systemic Autoimmune Disease

Genetic Tests for Systemic Autoimmune Disease

Anatomical Context for Systemic Autoimmune Disease

MalaCards organs/tissues related to Systemic Autoimmune Disease:

T Cells, B Cells, Bone, Lung, Bone Marrow, Salivary Gland, Endothelial

Publications for Systemic Autoimmune Disease

Articles related to Systemic Autoimmune Disease:

(show top 50) (show all 1592)
# Title Authors PMID Year
BXSB/MpJ-Yaa mouse model of systemic autoimmune disease shows increased apoptotic germ cells in stage XII of the seminiferous epithelial cycle. 61
32248303 2020
Regulatory T cells in patients with early untreated rheumatoid arthritis: Phenotypic changes in the course of methotrexate treatment. 61
32275944 2020
Delivery of benzoylaconitine using biodegradable nanoparticles to suppress inflammation via regulating NF-κB signaling. 61
32252000 2020
Altered ciliary morphofunction in the oviductal infundibulum of systemic autoimmune disease-prone MRL/MpJ-Faslpr/lpr mice. 61
32025875 2020
Candida bloodstream infection in patients with systemic autoimmune diseases. 61
32113868 2020
Rheumatologic Disorders and the Nervous System. 61
32487898 2020
Newly diagnosed iron deficiency anemia and subsequent autoimmune disease: a matched cohort study in Taiwan. 61
32223346 2020
Tertiary Lymphoid Organs in Rheumatoid Arthritis. 61
32483659 2020
Current insights in the pathogenesis of scleritis. 61
32504648 2020
Carotid plaques in adult rheumatoid arthritis patients; association with paroxonase 1 enzymatic activity and Q192R paroxonase 1 gene polymorphism. 61
32472296 2020
Inhibiting role of long non-coding RNA LINC01197 in inflammation in rheumatoid arthritis through the microRNA-150/THBS2 axis. 61
32540401 2020
Traditional Chinese medicine on treating active rheumatoid arthritis: A protocol for systematic review and meta-analysis. 61
32541503 2020
Are lupus animal models useful for understanding and developing new therapies for human SLE? 61
32535128 2020
Comparison of three ultrasonographic examinations on the synovial membrane vascularity of RA patients. 61
32358664 2020
Association of rheumatoid arthritis with hearing loss: a systematic review and meta-analysis. 61
32488430 2020
Peficitinib for the treatment of rheumatoid arthritis: an overview from clinical trials. 61
32345068 2020
Proteomics of saliva, plasma, and salivary gland tissue in Sjögren's syndrome and non-Sjögren patients identify novel biomarker candidates. 61
32540407 2020
Daphnetin induces apoptosis in fibroblast-like synoviocytes from collagen-induced arthritic rats mainly via the mitochondrial pathway. 61
32505094 2020
The pathogenesis of systemic lupus erythematosus: Harnessing big data to understand the molecular basis of lupus. 61
31806421 2020
Diversity of neuropsychiatric manifestations in systemic lupus erythematosus. 61
32459601 2020
In search of pathobiological endotypes: a systems approach to early rheumatoid arthritis. 61
32456483 2020
Immunobiology of T Cells in Sjögren's Syndrome. 61
32390096 2020
T cell exosome-derived miR-142-3p impairs glandular cell function in Sjögren's syndrome. 61
32376798 2020
Environmental factors in the pathogenesis of primary Sjögren's syndrome. 61
32107824 2020
Plasma exosomal miRNAs involved in endothelial injury in microscopic polyangiitis patients. 61
32232900 2020
[Lupus and thrombophilia : Antiphospholipid syndrome]. 61
32300863 2020
Comprehensive TCR repertoire analysis of CD4+ T-cell subsets in rheumatoid arthritis. 61
32115259 2020
Prevalence and demographics of multiple sclerosis-associated uveitis: a UK biobank study. 61
32480346 2020
The profiles of miRNAs and lncRNAs in peripheral blood neutrophils exosomes of diffuse cutaneous systemic sclerosis. 61
32147195 2020
Characterization of Plasma-Derived Small Extracellular Vesicles Indicates Ongoing Endothelial and Platelet Activation in Patients with Thrombotic Antiphospholipid Syndrome. 61
32414170 2020
Pathogenesis of ANCA-associated vasculitis: an emerging role for immunometabolism. 61
32348520 2020
Dietary Habits and Nutrition in Rheumatoid Arthritis: Can Diet Influence Disease Development and Clinical Manifestations? 61
32443535 2020
Peritoneal Carcinomatosis in an Adult With Sjögren's Syndrome: A Diagnostic Dilemma Revealing a Rare Association With Primary Gastric Adenocarcinoma. 61
32426201 2020
Systemic Autoimmune Disease Among Adults Exposed to the September 11, 2001 Terrorist Attack. 61
31762219 2020
Targeting of Phospholipase D1 Ameliorates Collagen-Induced Arthritis via Modulation of Treg and Th17 Cell Imbalance and Suppression of Osteoclastogenesis. 61
32370217 2020
In-Hospital Mortality-Associated Factors in Patients With Thrombotic Antiphospholipid Syndrome Requiring ICU Admission. 61
31783015 2020
Predictors of progression in systemic sclerosis patients with interstitial lung disease. 61
32079645 2020
Decrease in alpha-1 antiproteinase antitrypsin is observed in primary Sjogren's syndrome condition. 61
32449389 2020
Critically ill SARS-CoV-2 patients display lupus-like hallmarks of extrafollicular B cell activation. 61
32511635 2020
Elevated EPSTI1 promote B cell hyperactivation through NF-κB signalling in patients with primary Sjögren's syndrome. 61
32114510 2020
[Antinuclear antibodies in systemic autoimmune disease]. 61
32324347 2020
Expression of membrane-bound human leucocyte antigen-G in systemic sclerosis and systemic lupus erythematosus. 61
31848026 2020
[Seronegative antiphospholipid syndrome: Myth or reality?] 61
32115196 2020
Disseminated histoplasmosis in primary Sjögren syndrome: A case report. 61
32337209 2020
[Recommendations of diagnosis and treatment of primary Sjögren's syndrome in China]. 61
32209192 2020
Targeted drug-delivery systems in the treatment of rheumatoid arthritis: recent advancement and clinical status. 61
32434463 2020
Association of Dickkopf-1 Polymorphisms With Radiological Damage and Periodontal Disease in Patients With Early Rheumatoid Arthritis: A Cross-Sectional Study. 61
32332267 2020
Glucose-6-phosphate isomerase is associated with disease activity and declines in response to infliximab treatment in rheumatoid arthritis. 61
32187052 2020
Autoimmune pulmonary alveolar proteinosis developed during immunosuppressive treatment in polymyositis with interstitial lung disease: a case report. 61
32252718 2020
MicroRNA let-7g-5p alleviates murine collagen-induced arthritis by inhibiting Th17 cell differentiation. 61
31987855 2020

Variations for Systemic Autoimmune Disease

Copy number variations for Systemic Autoimmune Disease from CNVD:

# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 21054 1 156500000 165500000 Duplication FCGR3B Systemic autoimmune disease

Expression for Systemic Autoimmune Disease

Search GEO for disease gene expression data for Systemic Autoimmune Disease.

Pathways for Systemic Autoimmune Disease

Pathways related to Systemic Autoimmune Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
11.77 MMP9 IL6 IL17A
2 11.59 IL6 FCGR3A FCGR2B
3 10.9 MMP9 IL6
4 10.86 MMP9 IL6 IL17A
5 10.83 IL6 IL17A
6 10.23 IL6 CRP

GO Terms for Systemic Autoimmune Disease

Biological processes related to Systemic Autoimmune Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.56 IL6 IL17A FCGR2B CRP
2 acute-phase response GO:0006953 9.37 IL6 CRP
3 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.32 IL6 IL17A
4 regulation of neuroinflammatory response GO:0150077 9.16 MMP9 IL6
5 immune response GO:0006955 9.02 IL6 IL17A FCGR3A FCGR2B AIRE
6 negative regulation of lipid storage GO:0010888 8.96 IL6 CRP

Molecular functions related to Systemic Autoimmune Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 8.62 FCGR3A FCGR2B

Sources for Systemic Autoimmune Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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