MCID: SYS001
MIFTS: 86

Systemic Lupus Erythematosus

Categories: Genetic diseases, Rare diseases, Nephrological diseases, Immune diseases, Bone diseases, Skin diseases

Aliases & Classifications for Systemic Lupus Erythematosus

MalaCards integrated aliases for Systemic Lupus Erythematosus:

Name: Systemic Lupus Erythematosus 57 38 12 76 25 54 75 37 29 6 3 15
Lupus Nephritis 57 12 53 37 55 44 15 73
Lupus Erythematosus, Systemic 12 44 73
Sle 57 25 75
Systemic Lupus Erythematosus, Susceptibility to 57 6
Lupus Nephritis, Susceptibility to 57 6
Disseminated Lupus Erythematosus 12 25
Libman-Sacks Disease 25 73
Lupus Erythematosus, Systemic, Susceptibility to 40
Systemic Lupus Erythematosus Susceptibility to 57
Sle - Lupus Erythematosus, Systemic 12
Lupus Erythematosus Systemic 55
Lupus Erythematosus, Discoid 73
Lupus Erythematosus 73
Lupus Vulgaris 73
Le Syndrome 25
Lupus 25

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
complement deficiency (e.g. c2 and c4 null alleles) are susceptible to developing sle
association between hla class ii alleles and presence of autoantibodies
onset between ages 16-55
female to male ratio 8-13:1


HPO:

32
systemic lupus erythematosus:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Systemic Lupus Erythematosus

NINDS : 54 Lupus (also called systemic lupus erythematosus) is a disorder of the immune system. Normally, the immune system protects the body against invading infections and cancers. In lupus, the immune system is over-active and produces increased amounts of abnormal antibodies that attack the body's tissues and organs. Lupus can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, nervous system, and blood vessels. The signs and symptoms of lupus differ from person to person; the disease can range from mild to life threatening. Initial symptoms of lupus may begin with a fever, vascular headaches, epilepsy, or psychoses. A striking feature of lupus is a butterfly shaped rash over the cheeks. In addition to headache, lupus can cause other neurological disorders, such as mild cognitive dysfunction, organic brain syndrome, peripheral neuropathies, sensory neuropathy, psychological problems (including personality changes, paranoia, mania, and schizophrenia), seizures, transverse myelitis, and paralysis and stroke.

MalaCards based summary : Systemic Lupus Erythematosus, also known as lupus nephritis, is related to lupus erythematosus and systemic lupus erythematosus 16, and has symptoms including exanthema, pruritus and lupus-like rash. An important gene associated with Systemic Lupus Erythematosus is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Systemic lupus erythematosus and NF-kappaB Signaling. The drugs Simvastatin and 4-Aminopyridine have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, t cells and skin, and related phenotypes are nephritis and psychosis

Disease Ontology : 12 A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.

Genetics Home Reference : 25 Systemic lupus erythematosus (SLE) is a chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels, which provide strength and flexibility to structures throughout the body. The signs and symptoms of SLE vary among affected individuals, and can involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous system, and blood-forming (hematopoietic) system. SLE is one of a large group of conditions called autoimmune disorders that occur when the immune system attacks the body's own tissues and organs.

NIH Rare Diseases : 53 Lupus nephritis is a kidney disorder that is a complication of systemic lupus erythematous (SLE), commonly known as lupus. The symptoms of lupus nephritis include blood in the urine, a foamy appearance to the urine, high blood pressure, and swelling in any part of the body. This condition typically occurs in people aged 20 to 40 years. Treatment may involve medications to suppress the immune system, dialysis, or a kidney transplant. Visit our Web page on lupus for more information and resources.

OMIM : 57 Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by Oishi et al., 2008). (152700)

CDC : 3 Lupus occurs when an unknown trigger causes a person’s own immune system to attack their tissues, damaging the tissues and producing widespread inflammation. There is no known cause or cure for lupus; however, treatments are available.

UniProtKB/Swiss-Prot : 75 Systemic lupus erythematosus: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Wikipedia : 76 Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease in which the... more...

Related Diseases for Systemic Lupus Erythematosus

Diseases in the Lupus Erythematosus family:

Systemic Lupus Erythematosus Systemic Lupus Erythematosus 15
Systemic Lupus Erythematosus 1 Systemic Lupus Erythematosus 2
Systemic Lupus Erythematosus 3 Systemic Lupus Erythematosus 4
Systemic Lupus Erythematosus 5 Systemic Lupus Erythematosus 6
Systemic Lupus Erythematosus 7 Systemic Lupus Erythematosus 8
Systemic Lupus Erythematosus 9 Systemic Lupus Erythematosus 10
Systemic Lupus Erythematosus 11 Systemic Lupus Erythematosus 12
Systemic Lupus Erythematosus 13 Systemic Lupus Erythematosus 14
Systemic Lupus Erythematosus 16

Diseases related to Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 911, show less)
# Related Disease Score Top Affiliating Genes
1 lupus erythematosus 36.6 BANK1 C4A C4B CR2 CTLA4 DNASE1
2 systemic lupus erythematosus 16 36.2 C4A DNASE1
3 pediatric systemic lupus erythematosus 35.9 C4A C4B STAT4
4 rheumatoid arthritis 33.3 CTLA4 MALAT1 PTPN22 STAT4 TNF
5 autoimmune disease 33.1 CTLA4 FCGR2A FCGR2B PDCD1 PTPN22 STAT4
6 wegener granulomatosis 32.2 CTLA4 PTPN22 STAT4 TNF
7 anca-associated vasculitis 31.8 CTLA4 TNF
8 celiac disease 1 31.8 CTLA4 PTPN22 TNF
9 alopecia areata 31.7 CTLA4 PTPN22 TNF
10 inflammatory bowel disease 31.6 CTLA4 PTPN22 STAT4 TLR5 TNF
11 primary biliary cholangitis 31.5 CTLA4 PTPN22
12 diabetes mellitus 31.3 C4A CTLA4 MALAT1 PTPN22 TNF
13 systemic lupus erythematosus 1 12.6
14 systemic lupus erythematosus 2 12.6
15 systemic lupus erythematosus 9 12.5
16 systemic lupus erythematosus 10 12.5
17 systemic lupus erythematosus 6 12.5
18 systemic lupus erythematosus 11 12.5
19 systemic lupus erythematosus 3 12.4
20 systemic lupus erythematosus 4 12.4
21 systemic lupus erythematosus 5 12.4
22 systemic lupus erythematosus 7 12.4
23 systemic lupus erythematosus 12 12.4
24 neonatal systemic lupus erythematosus 12.3
25 systemic lupus erythematosus with hemolytic anemia 1 12.3
26 systemic lupus erythematosus 15 12.2
27 systemic lupus erythematosus with nephritis 1 12.2
28 systemic lupus erythematosus with nephritis 2 12.2
29 systemic lupus erythematosus with nephritis 3 12.2
30 systemic lupus erythematosus 8 12.2
31 systemic lupus erythematosus 13 12.2
32 systemic lupus erythematosus 14 12.2
33 neonatal lupus erythematosus 12.1
34 vitiligo-associated multiple autoimmune disease susceptibility 1 11.9
35 c1q deficiency 11.7
36 mixed connective tissue disease 11.7
37 behcet syndrome 11.5 C4A CTLA4 STAT4 TNF
38 multifocal motor neuropathy 11.5 BANK1 FCGR2B PTPN22
39 sympathetic ophthalmia 11.5 CTLA4 PDCD1 TNF
40 oligoarticular juvenile idiopathic arthritis 11.5 PTPN22 STAT4 TNF
41 severe hemophilia a 11.5 CTLA4 FCGR2A TNF
42 drug-induced lupus erythematosus 11.4
43 hypogonadotropic hypogonadism 11.4
44 pure red-cell aplasia 11.4
45 cutaneous lupus erythematosus 11.4
46 sjogren syndrome 11.4
47 macrophage activation syndrome 11.4
48 epidermolysis bullosa acquisita 11.4
49 immunodeficiency due to a classical component pathway complement deficiency 11.4 C4A C4B
50 renal tubular acidosis, distal 11.4
51 complement component 2 deficiency 11.4
52 sneddon syndrome 11.4
53 complement component 3 deficiency, autosomal recessive 11.4
54 complement component c1s deficiency 11.4
55 rapidly progressive glomerulonephritis 11.4
56 lupus erythematosus tumidus 11.4
57 spondyloenchondrodysplasia 11.4
58 rheumatoid factor-negative juvenile idiopathic arthritis 11.4 PTPN22 STAT4
59 autoimmune addison disease 11.4 CTLA4 PTPN22
60 juvenile dermatitis herpetiformis 11.3 C4A C4B
61 autoimmune pancreatitis 11.3 CTLA4 TNF
62 anterior uveitis 11.2 CTLA4 PTPN22
63 mesangial proliferative glomerulonephritis 11.2
64 epilepsy, familial temporal lobe, 2 11.1 C4A C4B
65 pseudo-torch syndrome 1 11.1
66 glomerulopathy with fibronectin deposits 2 11.1
67 chilblain lupus 1 11.1
68 autoimmune disease 6 11.1
69 chilblain lupus 2 11.1
70 aicardi-goutieres syndrome 11.1
71 autoimmune inner ear disease 11.1
72 c1q nephropathy 11.1
73 insulin-resistance type b 11.1
74 singleton-merten syndrome 11.1
75 lupus - neurological sequelae 11.1
76 myasthenic syndrome, congenital, 7, presynaptic 11.0 CTLA4 PDCD1
77 arthritis 10.9
78 antiphospholipid syndrome 10.7
79 vasculitis 10.6
80 thrombosis 10.6
81 endotheliitis 10.6
82 myelitis 10.6
83 cerebritis 10.5
84 connective tissue disease 10.5
85 transverse myelitis 10.5
86 purpura 10.5
87 hepatitis 10.5
88 scleroderma, familial progressive 10.5
89 protein-losing enteropathy 10.5
90 type i 10.5
91 retinitis 10.4
92 glomerulonephritis 10.4
93 aging 10.4
94 lymphoma 10.4
95 thyroiditis 10.4
96 thrombocytopenia 10.4
97 diffuse alveolar hemorrhage 10.4
98 thrombotic thrombocytopenic purpura 10.4
99 autoimmune disease 1 10.3
100 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
101 intestinal pseudo-obstruction 10.3
102 pneumonia 10.3
103 discoid lupus erythematosus 10.3
104 dermatomyositis 10.3
105 lymphopenia 10.3
106 depression 10.3
107 meningitis 10.3
108 osteonecrosis 10.3
109 cardiac tamponade 10.3
110 arthropathy 10.3
111 pulmonary hypertension 10.3
112 neuropathy 10.3
113 atrial standstill 1 10.3
114 pancreatitis 10.3
115 aneurysm 10.3
116 hemolytic anemia 10.3
117 rheumatic disease 10.3
118 vascular disease 10.3
119 enthesopathy 10.3
120 multiple sclerosis 10.2
121 myasthenia gravis 10.2
122 myocardial infarction 10.2
123 autoimmune hepatitis 10.2
124 myasthenia gravis congenital 10.2
125 optic neuritis 10.2
126 porphyria 10.2
127 neuritis 10.2
128 cholecystitis 10.2
129 complement deficiency 10.2
130 herpes zoster 10.2
131 nervous system disease 10.2
132 anemia, autoimmune hemolytic 10.2
133 heart block, congenital 10.2
134 panniculitis 10.2
135 calcinosis 10.2
136 acalculous cholecystitis 10.2
137 progressive multifocal leukoencephalopathy 10.2
138 pemphigus 10.2
139 diabetes mellitus, noninsulin-dependent 10.2
140 membranous nephropathy 10.2
141 retinal vasculitis 10.2
142 dermatitis 10.2
143 central nervous system disease 10.2
144 juvenile rheumatoid arthritis 10.2
145 myocarditis 10.2
146 fasciitis 10.2
147 hyperprolactinemia 10.2
148 leukemia 10.2
149 neutropenia 10.2
150 renal tubular acidosis 10.2
151 pericarditis 10.2
152 influenza 10.2
153 myositis 10.2
154 bronchiolitis obliterans 10.2
155 neuromyelitis optica 10.2
156 colitis 10.2
157 heart disease 10.2
158 hypothyroidism 10.2
159 lymphadenitis 10.2
160 bronchiolitis 10.2
161 thrombophilia due to thrombin defect 10.1
162 polyneuropathy 10.1
163 hepatitis c 10.1
164 nocardiosis 10.1
165 calciphylaxis 10.1
166 septic arthritis 10.1
167 peritonitis 10.1
168 catastrophic antiphospholipid syndrome 10.1
169 polymyositis 10.1
170 encephalopathy 10.1
171 subacute cutaneous lupus erythematosus 10.1
172 arteries, anomalies of 10.1
173 porphyria cutanea tarda 10.1
174 intracranial hypertension, idiopathic 10.1
175 familial mediterranean fever 10.1
176 systemic scleroderma 10.1
177 endocarditis 10.1
178 meningoencephalitis 10.1
179 brucellosis 10.1
180 hemopericardium 10.1
181 angioedema 10.1
182 epidermolysis bullosa 10.1
183 acute pancreatitis 10.1
184 polyradiculoneuropathy 10.1
185 granulomatous dermatitis 10.1
186 proliferative glomerulonephritis 10.1
187 neuronitis 10.1
188 amyloidosis 10.1
189 intracranial hypertension 10.1
190 headache 10.1
191 biliary cirrhosis, primary, 1 10.1
192 pernicious anemia 10.1
193 myelofibrosis 10.1
194 complement component 4a deficiency 10.1
195 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
196 primary biliary cirrhosis 10.1
197 choroiditis 10.1
198 pericardial effusion 10.1
199 nephrotic syndrome 10.1
200 aseptic meningitis 10.1
201 thymoma 10.1
202 aortic aneurysm 10.1
203 syphilis 10.1
204 myopathy 10.1
205 periodontitis 10.1
206 lung disease 10.1
207 collagen disease 10.1
208 necrotizing fasciitis 10.1
209 hemophilia 10.1
210 fibromyalgia 10.1
211 cytomegalovirus infection 10.1
212 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.1
213 cardiac valvular defect, developmental 10.0
214 severe cutaneous adverse reaction 10.0
215 b-cell lymphomas 10.0
216 coronary artery anomaly 10.0
217 heart valve disease 10.0
218 hepatitis b 10.0
219 hydrocephalus 10.0
220 silicosis 10.0
221 sensorineural hearing loss 10.0
222 strongyloidiasis 10.0
223 hypoparathyroidism 10.0
224 pancytopenia 10.0
225 central retinal artery occlusion 10.0
226 hyperparathyroidism 10.0
227 urticaria 10.0
228 protein s deficiency 10.0
229 cryoglobulinemia 10.0
230 internuclear ophthalmoplegia 10.0
231 peripheral nervous system disease 10.0
232 retinal artery occlusion 10.0
233 encephalitis 10.0
234 miliary tuberculosis 10.0
235 acquired hemophilia 10.0
236 nodular regenerative hyperplasia 10.0
237 acute transverse myelitis 10.0
238 lupus erythematosus panniculitis 10.0
239 spondyloarthropathy 1 10.0
240 complement component 4, partial deficiency of 10.0
241 noonan syndrome 1 10.0
242 porphyria, acute intermittent 10.0
243 coronary heart disease 1 10.0
244 anxiety 10.0
245 aspergillosis 10.0
246 acute myocardial infarction 10.0
247 hematopoietic stem cell transplantation 10.0
248 hemophagocytic lymphohistiocytosis 10.0
249 c1 inhibitor deficiency 10.0
250 cytomegalovirus retinitis 10.0
251 cryptococcosis 10.0
252 hellp syndrome 10.0
253 pneumatosis cystoides intestinalis 10.0
254 cystitis 10.0
255 epilepsy 10.0
256 acute myocarditis 10.0
257 aortitis 10.0
258 demyelinating polyneuropathy 10.0
259 kidney disease 10.0
260 spondylitis 10.0
261 bullous pemphigoid 10.0
262 pyomyositis 10.0
263 linear scleroderma 10.0
264 pseudo-turner syndrome 10.0
265 cerebral atrophy 10.0
266 cryoglobulinemia, familial mixed 10.0
267 lymphoma, mucosa-associated lymphoid type 10.0
268 lymphedema, hereditary, ii 10.0
269 prolidase deficiency 10.0
270 pulmonary hypertension, primary, 1 10.0
271 thrombocytopenic purpura, autoimmune 10.0
272 eosinophilic fasciitis 10.0
273 epidermodysplasia verruciformis 10.0
274 premature ovarian failure 1 10.0
275 malignant atrophic papulosis 10.0
276 avascular necrosis of femoral head, primary, 1 10.0
277 aplastic anemia 10.0
278 mannose-binding lectin deficiency 10.0
279 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.0
280 alopecia 10.0
281 childhood type dermatomyositis 10.0
282 common variable immunodeficiency 10.0
283 crohn's disease 10.0
284 osteoarthritis 10.0
285 pulmonary sarcoidosis 10.0
286 ulcerative colitis 10.0
287 erythema multiforme 10.0
288 salmonellosis 10.0
289 osteomyelitis 10.0
290 pleurisy 10.0
291 secondary hyperparathyroidism of renal origin 10.0
292 jaccoud's syndrome 10.0
293 amenorrhea 10.0
294 adult dermatomyositis 10.0
295 histoplasmosis 10.0
296 mononeuritis multiplex 10.0
297 optic nerve disease 10.0
298 arteriosclerosis 10.0
299 relapsing polychondritis 10.0
300 interstitial lung disease 10.0
301 ischemia 10.0
302 coronary aneurysm 10.0
303 laryngitis 10.0
304 cranial nerve palsy 10.0
305 pyoderma 10.0
306 chronic inflammatory demyelinating polyradiculoneuropathy 10.0
307 cerebrovascular disease 10.0
308 pyoderma gangrenosum 10.0
309 sickle cell disease 10.0
310 kikuchi disease 10.0
311 b-cell growth factor 9.9
312 breast cancer 9.9
313 hashimoto thyroiditis 9.9
314 osteoporosis 9.9
315 ascites, chylous 9.9
316 chondrodysplasia punctata syndrome 9.9
317 lysinuric protein intolerance 9.9
318 myeloma, multiple 9.9
319 rheumatic fever-related antigen 9.9
320 asthma 9.9
321 dermatitis herpetiformis, familial 9.9
322 stroke, ischemic 9.9
323 focal segmental glomerulosclerosis 1 9.9
324 aceruloplasminemia 9.9
325 psoriatic arthritis 9.9
326 hepatitis c virus 9.9
327 malaria 9.9
328 kawasaki disease 9.9
329 complement component 4b deficiency 9.9
330 graft-versus-host disease 9.9
331 ataxia-oculomotor apraxia 3 9.9
332 polyarteritis nodosa, childhood-onset 9.9
333 glucocorticoid resistance, generalized 9.9
334 peripheral vascular disease 9.9
335 tendinitis 9.9
336 acute lymphocytic leukemia 9.9
337 chronic inflammatory demyelinating polyneuropathy 9.9
338 congestive heart failure 9.9
339 focal segmental glomerulosclerosis 9.9
340 liver disease 9.9
341 pemphigus foliaceus 9.9
342 retinal vein occlusion 9.9
343 lambert-eaton myasthenic syndrome 9.9
344 alexithymia 9.9
345 acquired von willebrand syndrome 9.9
346 tuberculoid leprosy 9.9
347 parotitis 9.9
348 lepromatous leprosy 9.9
349 hydronephrosis 9.9
350 respiratory failure 9.9
351 disseminated intravascular coagulation 9.9
352 portal vein thrombosis 9.9
353 neurogenic bladder 9.9
354 graves' disease 9.9
355 uveitis 9.9
356 interstitial cystitis 9.9
357 adult-onset still's disease 9.9
358 pyuria 9.9
359 candidiasis 9.9
360 communicating hydrocephalus 9.9
361 rheumatic fever 9.9
362 chronic interstitial cystitis 9.9
363 ichthyosis 9.9
364 cervicitis 9.9
365 membranoproliferative glomerulonephritis 9.9
366 periodontal disease 9.9
367 cellulitis 9.9
368 thrombophlebitis 9.9
369 central nervous system vasculitis 9.9
370 acquired immunodeficiency syndrome 9.9
371 acute disseminated encephalomyelitis 9.9
372 placenta disease 9.9
373 hyperthyroidism 9.9
374 dermatitis herpetiformis 9.9
375 herpes simplex 9.9
376 lichen planus 9.9
377 diabetes insipidus 9.9
378 polyarteritis nodosa 9.9
379 chronic graft versus host disease 9.9
380 heparin-induced thrombocytopenia 9.9
381 hypoaldosteronism 9.9
382 hypocomplementemic urticarial vasculitis 9.9
383 hyporeninemic hypoaldosteronism 9.9
384 ichthyosis, acquired 9.9
385 mycobacterium kansasii 9.9
386 retroperitoneal fibrosis 9.9
387 undifferentiated connective tissue disease 9.9
388 zygomycosis 9.9
389 pseudo-meigs syndrome 9.9
390 pemphigus erythematosus 9.9
391 refractory anemia 9.9
392 acanthosis nigricans 9.8
393 inclusion body myositis 9.8
394 pemphigus vulgaris, familial 9.8
395 pulmonary hemosiderosis 9.8
396 takayasu arteritis 9.8
397 hemolytic uremic syndrome, atypical 1 9.8
398 hydrocephalus, normal-pressure 9.8
399 fabry disease 9.8
400 hemophilia a 9.8
401 taqi polymorphism 9.8
402 budd-chiari syndrome 9.8
403 autoimmune lymphoproliferative syndrome 9.8
404 reflex sympathetic dystrophy 9.8
405 orthostatic intolerance 9.8
406 anorexia nervosa 9.8
407 factor xi deficiency 9.8
408 dengue virus 9.8
409 peripartum cardiomyopathy 9.8
410 adult respiratory distress syndrome 9.8
411 aortic atherosclerosis 9.8
412 chronic kidney failure 9.8
413 dengue disease 9.8
414 marginal zone b-cell lymphoma 9.8
415 paroxysmal nocturnal hemoglobinuria 9.8
416 pemphigus vulgaris 9.8
417 pulmonary fibrosis 9.8
418 skin disease 9.8
419 temporal lobe epilepsy 9.8
420 invasive aspergillosis 9.8
421 peripheral artery disease 9.8
422 inflammatory myofibroblastic tumor 9.8
423 immunoglobulin alpha deficiency 9.8
424 ischemic colitis 9.8
425 collagenous colitis 9.8
426 purpura fulminans 9.8
427 lymphoproliferative syndrome 9.8
428 cryptococcal meningitis 9.8
429 castleman disease 9.8
430 mastitis 9.8
431 q fever 9.8
432 henoch-schoenlein purpura 9.8
433 t cell deficiency 9.8
434 spondyloarthropathy 9.8
435 tetanus 9.8
436 pulmonary edema 9.8
437 palindromic rheumatism 9.8
438 dysgammaglobulinemia 9.8
439 conn's syndrome 9.8
440 hemosiderosis 9.8
441 pulmonary alveolar proteinosis 9.8
442 hemolytic-uremic syndrome 9.8
443 tolosa-hunt syndrome 9.8
444 guillain-barre syndrome 9.8
445 crescentic glomerulonephritis 9.8
446 gout 9.8
447 algoneurodystrophy 9.8
448 neuroleptic malignant syndrome 9.8
449 hereditary angioedema 9.8
450 diffuse scleroderma 9.8
451 thrombocytopenia due to platelet alloimmunization 9.8
452 renovascular hypertension 9.8
453 squamous cell carcinoma 9.8
454 mitral valve stenosis 9.8
455 thyroid cancer 9.8
456 status epilepticus 9.8
457 chronic mucocutaneous candidiasis 9.8
458 thrombocytosis 9.8
459 gastroenteritis 9.8
460 central retinal vein occlusion 9.8
461 retinal vascular disease 9.8
462 kluver-bucy syndrome 9.8
463 splenic abscess 9.8
464 splenic infarction 9.8
465 papilloma 9.8
466 synovitis 9.8
467 bursitis 9.8
468 gingivitis 9.8
469 proctitis 9.8
470 nemaline myopathy 9.8
471 histiocytosis 9.8
472 sagittal sinus thrombosis 9.8
473 shwartzman phenomenon 9.8
474 eosinophilic gastroenteritis 9.8
475 polyradiculopathy 9.8
476 tinea capitis 9.8
477 movement disease 9.8
478 arteriosclerosis obliterans 9.8
479 sleep disorder 9.8
480 cerebral lymphoma 9.8
481 hemoglobinuria 9.8
482 mitral valve disease 9.8
483 conjunctivitis 9.8
484 reactive arthritis 9.8
485 pericardial mesothelioma 9.8
486 adenoma 9.8
487 anterior spinal artery syndrome 9.8
488 t-cell leukemia 9.8
489 axonal neuropathy 9.8
490 scabies 9.8
491 paralytic ileus 9.8
492 localized scleroderma 9.8
493 malignant histiocytosis 9.8
494 lymphosarcoma 9.8
495 evans' syndrome 9.8
496 peliosis hepatis 9.8
497 priapism 9.8
498 scotoma 9.8
499 carotid artery dissection 9.8
500 exophthalmos 9.8
501 epiglottitis 9.8
502 tenosynovitis 9.8
503 deep keratitis 9.8
504 periostitis 9.8
505 hypereosinophilic syndrome 9.8
506 hypoglycemia 9.8
507 acquired hemophilia a 9.8
508 amaurosis fugax 9.8
509 autoimmune retinopathy 9.8
510 central serous chorioretinopathy 9.8
511 chronic active epstein-barr virus infection 9.8
512 coronary artery aneurysm 9.8
513 eosinophilic enteropathy 9.8
514 gigantism 9.8
515 gigantomastia 9.8
516 hyper ige syndrome 9.8
517 limbic encephalitis 9.8
518 lymphocytic hypophysitis 9.8
519 malakoplakia 9.8
520 mycobacterium fortuitum 9.8
521 neuromyelitis optica spectrum disorder 9.8
522 oral lichen planus 9.8
523 papular mucinosis 9.8
524 reversible cerebral vasoconstriction syndrome 9.8
525 rosai-dorfman disease 9.8
526 sudden sensorineural hearing loss 9.8
527 autonomic dysfunction 9.8
528 syncope 9.8
529 paraneoplastic pemphigus 9.8
530 cardiogenic shock 9.8
531 cytophagic histiocytic panniculitis 9.8
532 abducens palsy 9.7
533 acroosteolysis 9.7
534 angioedema, hereditary, type i 9.7
535 bladder cancer 9.7
536 colorectal cancer 9.7
537 cardiac conduction defect 9.7
538 creutzfeldt-jakob disease 9.7
539 diabetes insipidus, nephrogenic, autosomal 9.7
540 periodic fever, familial, autosomal dominant 9.7
541 intussusception 9.7
542 lichen sclerosus et atrophicus 9.7
543 moebius syndrome 9.7
544 myelopathy, htlv-1-associated 9.7
545 parkinson disease, late-onset 9.7
546 prader-willi syndrome 9.7
547 protoporphyria, erythropoietic 9.7
548 schizophrenia 9.7
549 spinocerebellar ataxia 6 9.7
550 stiff-person syndrome 9.7
551 thyroid cancer, nonmedullary, 1 9.7
552 torticollis 9.7
553 trichomegaly 9.7
554 trichorhinophalangeal syndrome, type i 9.7
555 trigeminal neuralgia 9.7
556 acid phosphatase deficiency 9.7
557 alopecia universalis congenita 9.7
558 cystic fibrosis 9.7
559 enterocolitis 9.7
560 galactorrhea 9.7
561 factor xii deficiency 9.7
562 dubin-johnson syndrome 9.7
563 hypogonadism, male 9.7
564 moyamoya disease 1 9.7
565 mycosis fungoides 9.7
566 3-methylglutaconic aciduria, type iii 9.7
567 pancreatic agenesis 1 9.7
568 pseudoxanthoma elasticum 9.7
569 fragile x syndrome 9.7
570 wiskott-aldrich syndrome 9.7
571 immunodeficiency with hyper-igm, type 1 9.7
572 transsexuality 9.7
573 leukemia, acute myeloid 9.7
574 bile duct cysts 9.7
575 macular degeneration, age-related, 1 9.7
576 homocysteinemia 9.7
577 ventricular fibrillation, paroxysmal familial, 1 9.7
578 rheumatoid arthritis, systemic juvenile 9.7
579 body mass index quantitative trait locus 1 9.7
580 lymphangioleiomyomatosis 9.7
581 aortic aneurysm, familial thoracic 1 9.7
582 resting heart rate, variation in 9.7
583 juvenile myelomonocytic leukemia 9.7
584 endometrial cancer 9.7
585 ovarian hyperstimulation syndrome 9.7
586 leukemia, chronic myeloid 9.7
587 carotid intimal medial thickness 2 9.7
588 legionnaire disease 9.7
589 pulmonary alveolar proteinosis, acquired 9.7
590 antithrombin iii deficiency 9.7
591 cholangitis, primary sclerosing 9.7
592 aortic valve disease 2 9.7
593 human herpesvirus 8 9.7
594 melioidosis 9.7
595 autoimmune lymphoproliferative syndrome, type v 9.7
596 retinitis pigmentosa and erythrocytic microcytosis 9.7
597 adult t-cell leukemia 9.7
598 bipolar disorder 9.7
599 burns 9.7
600 cataract 9.7
601 cerebral hemorrhage 9.7
602 chronic granulomatous disease 9.7
603 chronic myelomonocytic leukemia 9.7
604 diffuse large b-cell lymphoma 9.7
605 dilated cardiomyopathy 9.7
606 granuloma annulare 9.7
607 hemangioma 9.7
608 intraocular lymphoma 9.7
609 liver cirrhosis 9.7
610 lymphomatoid granulomatosis 9.7
611 mannosidosis 9.7
612 chikungunya 9.7
613 autoimmune polyendocrine syndrome type 1 9.7
614 swine influenza 9.7
615 hypophosphatemia 9.7
616 extrapulmonary tuberculosis 9.7
617 abdominal tuberculosis 9.7
618 t-cell large granular lymphocyte leukemia 9.7
619 rheumatic heart disease 9.7
620 hemorrhagic cystitis 9.7
621 villous adenoma 9.7
622 infective endocarditis 9.7
623 atrial fibrillation 9.7
624 erythema elevatum diutinum 9.7
625 bone disease 9.7
626 meningococcal meningitis 9.7
627 mucositis 9.7
628 partial lipodystrophy 9.7
629 acquired generalized lipodystrophy 9.7
630 angioimmunoblastic t-cell lymphoma 9.7
631 multicentric castleman disease 9.7
632 syphilitic meningitis 9.7
633 cysticercosis 9.7
634 venous insufficiency 9.7
635 dry eye syndrome 9.7
636 neuroretinitis 9.7
637 asbestosis 9.7
638 chronic meningitis 9.7
639 hypopyon 9.7
640 legionnaires' disease 9.7
641 pre-eclampsia 9.7
642 glucose intolerance 9.7
643 paragonimiasis 9.7
644 portal hypertension 9.7
645 methemoglobinemia 9.7
646 malignant hypertension 9.7
647 transsexualism 9.7
648 intracranial aneurysm 9.7
649 sarcoma 9.7
650 enophthalmos 9.7
651 primary hyperparathyroidism 9.7
652 vitamin k deficiency hemorrhagic disease 9.7
653 cat-scratch disease 9.7
654 lemierre's syndrome 9.7
655 epidural abscess 9.7
656 subdural empyema 9.7
657 pyelonephritis 9.7
658 xanthogranulomatous pyelonephritis 9.7
659 diphtheria 9.7
660 constrictive pericarditis 9.7
661 autonomic neuropathy 9.7
662 hypertensive retinopathy 9.7
663 cicatricial pemphigoid 9.7
664 lyme disease 9.7
665 multicentric reticulohistiocytosis 9.7
666 myopia 9.7
667 cortical blindness 9.7
668 mononeuropathy 9.7
669 ecthyma 9.7
670 esophagitis 9.7
671 hypertrophic cardiomyopathy 9.7
672 chagas disease 9.7
673 pseudoretinitis pigmentosa 9.7
674 superficial keratitis 9.7
675 von willebrand's disease 9.7
676 hepatitis a 9.7
677 pyloric stenosis 9.7
678 paracoccidioidomycosis 9.7
679 nephrocalcinosis 9.7
680 hypercementosis 9.7
681 miller fisher syndrome 9.7
682 endomyocardial fibrosis 9.7
683 eumycotic mycetoma 9.7
684 typhoid fever 9.7
685 scleritis 9.7
686 tuberous sclerosis 9.7
687 eclampsia 9.7
688 posterior scleritis 9.7
689 hepatic infarction 9.7
690 hypermobility syndrome 9.7
691 necrotizing ulcerative gingivitis 9.7
692 facial paralysis 9.7
693 splenic artery aneurysm 9.7
694 poems syndrome 9.7
695 autoimmune polyendocrine syndrome 9.7
696 bipolar i disorder 9.7
697 neonatal myasthenia gravis 9.7
698 phaeohyphomycosis 9.7
699 toxic shock syndrome 9.7
700 obstructive hydrocephalus 9.7
701 selective igg deficiency disease 9.7
702 oral candidiasis 9.7
703 sclerosing cholangitis 9.7
704 suppurative thyroiditis 9.7
705 autosomal dominant cerebellar ataxia 9.7
706 herpes gestationis 9.7
707 chorea gravidarum 9.7
708 reye syndrome 9.7
709 papilledema 9.7
710 prostatitis 9.7
711 disease of mental health 9.7
712 hypersensitivity reaction type iii disease 9.7
713 chromoblastomycosis 9.7
714 central nervous system tuberculosis 9.7
715 retinal vascular occlusion 9.7
716 cheilitis 9.7
717 conversion disorder 9.7
718 impotence 9.7
719 hyperuricemia 9.7
720 hypogonadism 9.7
721 intestinal perforation 9.7
722 blood platelet disease 9.7
723 granulomatous hepatitis 9.7
724 transient cerebral ischemia 9.7
725 pharyngitis 9.7
726 thrombophilia 9.7
727 pigmented villonodular synovitis 9.7
728 endometriosis 9.7
729 pulmonary tuberculosis 9.7
730 kidney cortex necrosis 9.7
731 iga glomerulonephritis 9.7
732 cutis laxa 9.7
733 lipomatosis 9.7
734 tropical spastic paraparesis 9.7
735 tracheal stenosis 9.7
736 central nervous system lymphoma 9.7
737 thymus cancer 9.7
738 teratocarcinoma 9.7
739 teratoma 9.7
740 hyperglobulinemic purpura 9.7
741 liposarcoma 9.7
742 palmoplantar keratosis 9.7
743 turner syndrome 9.7
744 superior mesenteric artery syndrome 9.7
745 choriocarcinoma 9.7
746 brachial plexus neuropathy 9.7
747 hermansky-pudlak syndrome 9.7
748 protein c deficiency 9.7
749 anovulation 9.7
750 porokeratosis 9.7
751 loeffler endocarditis 9.7
752 restrictive cardiomyopathy 9.7
753 gastritis 9.7
754 secondary syphilis 9.7
755 pseudohypoparathyroidism 9.7
756 echolalia 9.7
757 hyperglycemia 9.7
758 hypertrichosis 9.7
759 macular retinal edema 9.7
760 large cell carcinoma 9.7
761 hydranencephaly 9.7
762 extragonadal germ cell cancer 9.7
763 intracranial hypotension 9.7
764 subacute glomerulonephritis 9.7
765 cavernous hemangioma 9.7
766 gerstmann syndrome 9.7
767 aortic disease 9.7
768 infertility 9.7
769 blepharospasm 9.7
770 pulmonary venoocclusive disease 9.7
771 anal squamous cell carcinoma 9.7
772 diffuse pulmonary fibrosis 9.7
773 retinal disease 9.7
774 aortic valve insufficiency 9.7
775 inferior myocardial infarction 9.7
776 brown-sequard syndrome 9.7
777 central pontine myelinolysis 9.7
778 adrenal adenoma 9.7
779 bilateral breast cancer 9.7
780 compartment syndrome 9.7
781 subacute thyroiditis 9.7
782 nodular episcleritis 9.7
783 hemarthrosis 9.7
784 carotid artery occlusion 9.7
785 mediastinitis 9.7
786 actinomycosis 9.7
787 impetigo 9.7
788 subcorneal pustular dermatosis 9.7
789 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.7
790 chronic fatigue syndrome 9.7
791 subacute delirium 9.7
792 myeloid leukemia 9.7
793 psoriasis 9.7
794 dermatophytosis 9.7
795 sideroblastic anemia 9.7
796 liver lymphoma 9.7
797 leishmaniasis 9.7
798 macroglobulinemia 9.7
799 visceral leishmaniasis 9.7
800 erythromelalgia 9.7
801 iridocyclitis 9.7
802 blepharitis 9.7
803 cholangitis 9.7
804 fatty liver disease 9.7
805 bacterial meningitis 9.7
806 pulmonary embolism 9.7
807 dacryoadenitis 9.7
808 dextrocardia 9.7
809 babesiosis 9.7
810 renal tuberculosis 9.7
811 diastolic heart failure 9.7
812 irritable bowel syndrome 9.7
813 tuberculous peritonitis 9.7
814 hypersensitivity vasculitis 9.7
815 median arcuate ligament syndrome 9.7
816 villonodular synovitis 9.7
817 follicular mucinosis 9.7
818 toxoplasmosis 9.7
819 trichorhinophalangeal syndrome 9.7
820 47, xxy 9.7
821 acquired angioedema 9.7
822 acute mountain sickness 9.7
823 amyloidosis aa 9.7
824 anton's syndrome 9.7
825 autoimmune myocarditis 9.7
826 banti's syndrome 9.7
827 bone marrow necrosis 9.7
828 bowen's disease 9.7
829 bowenoid papulosis 9.7
830 cardiac rupture 9.7
831 chorea minor 9.7
832 chronic hiccups 9.7
833 chronic intestinal pseudoobstruction 9.7
834 cold agglutinin disease 9.7
835 congenital cytomegalovirus 9.7
836 embryonal sarcoma 9.7
837 eosinophilic granulomatosis with polyangiitis 9.7
838 ewing's family of tumors 9.7
839 fibrillary glomerulonephritis 9.7
840 germ cells tumors 9.7
841 giant cell myocarditis 9.7
842 glioma 9.7
843 granulocytopenia 9.7
844 granulomatous lobular mastitis 9.7
845 haemophilus influenzae 9.7
846 immunoglobulin g deficiency 9.7
847 large granular lymphocyte leukemia 9.7
848 lichen sclerosus 9.7
849 linear iga disease 9.7
850 livedoid vasculopathy 9.7
851 lymphocytic vasculitis 9.7
852 mannose-binding lectin protein deficiency 9.7
853 meningococcal infection 9.7
854 microscopic polyangiitis 9.7
855 mollaret meningitis 9.7
856 muscular dystrophy white matter spongiosis 9.7
857 mycetoma 9.7
858 mycobacterium chelonae 9.7
859 mycobacterium marinum 9.7
860 mycobacterium xenopi 9.7
861 necrotizing autoimmune myopathy 9.7
862 nontuberculous mycobacterial lung disease 9.7
863 pasteurella multocida infection 9.7
864 pdgfrb-associated chronic eosinophilic leukemia 9.7
865 polyarticular onset juvenile idiopathic arthritis 9.7
866 primary central nervous system lymphoma 9.7
867 retroperitoneal liposarcoma 9.7
868 serpiginous choroiditis 9.7
869 spastic paraparesis 9.7
870 splenomegaly 9.7
871 synovial chondromatosis 9.7
872 syphilitic aseptic meningitis 9.7
873 systemic onset juvenile idiopathic arthritis 9.7
874 t-cell/histiocyte rich large b cell lymphoma 9.7
875 tetrasomy x 9.7
876 thrombasthenia 9.7
877 trochleitis 9.7
878 tuberculous meningitis 9.7
879 ulcerative proctitis 9.7
880 wells syndrome 9.7
881 central cord syndrome 9.7
882 dysautonomia 9.7
883 extrapontine myelinolysis 9.7
884 hypertonia 9.7
885 myoclonus 9.7
886 paraneoplastic syndromes 9.7
887 spasticity 9.7
888 undifferentiated embryonal sarcoma of the liver 9.7
889 vulvar intraepithelial neoplasia 9.7
890 low-flow priapism 9.7
891 acquired cutis laxa 9.7
892 phalangeal microgeodic syndrome 9.7
893 tafro syndrome 9.7
894 transient neonatal myasthenia gravis 9.7
895 juvenile myasthenia gravis 9.7
896 systemic polyarteritis nodosa 9.7
897 spontaneous intracranial hypotension 9.7
898 acquired prothrombin deficiency 9.7
899 acute macular neuroretinopathy 9.7
900 recurrent acute pancreatitis 9.7
901 hepatosplenic t-cell lymphoma 9.7
902 solar urticaria 9.7
903 acute adrenal insufficiency 9.7
904 atlantoaxial subluxation 9.7
905 intravascular large b-cell lymphoma 9.7
906 ischemic retinopathy 9.7
907 osteoporotic fracture 9.7
908 microvascular complications of diabetes 3 9.6
909 microvascular complications of diabetes 4 9.6
910 microvascular complications of diabetes 6 9.6
911 microvascular complications of diabetes 7 9.6

Comorbidity relations with Systemic Lupus Erythematosus via Phenotypic Disease Network (PDN): (showing 20, show less)


Acute Cystitis Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Heart Disease Hypersensitivity Vasculitis
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease Neutropenia
Osteoporosis Postinflammatory Pulmonary Fibrosis
Raynaud Phenomenon Rheumatoid Arthritis
Sjogren Syndrome Systemic Scleroderma

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus:



Diseases related to Systemic Lupus Erythematosus

Symptoms & Phenotypes for Systemic Lupus Erythematosus

Symptoms via clinical synopsis from OMIM:

57
Neurologic Central Nervous System:
seizures
psychosis

Hematology:
hemolytic anemia
thrombocytopenia
leukopenia

Respiratory Lung:
pleuritis

Genitourinary Kidneys:
nephritis

Laboratory Abnormalities:
antiphospholipid antibody
anti dsdna antibody
serum antinuclear antibody

Skeletal Limbs:
arthritis

Cardiovascular Heart:
pericarditis

Immunology:
systemic lupus erythematosus

Skin Nails Hair Skin:
photosensitivity
erythematous malar rash
discoid rash


Clinical features from OMIM:

152700

Human phenotypes related to Systemic Lupus Erythematosus:

32 (showing 13, show less)
# Description HPO Frequency HPO Source Accession
1 nephritis 32 HP:0000123
2 psychosis 32 HP:0000709
3 cutaneous photosensitivity 32 HP:0000992
4 seizures 32 HP:0001250
5 arthritis 32 HP:0001369
6 pericarditis 32 HP:0001701
7 thrombocytopenia 32 HP:0001873
8 hemolytic anemia 32 HP:0001878
9 leukopenia 32 HP:0001882
10 pleuritis 32 HP:0002102
11 systemic lupus erythematosus 32 HP:0002725
12 antinuclear antibody positivity 32 HP:0003493
13 antiphospholipid antibody positivity 32 HP:0003613

UMLS symptoms related to Systemic Lupus Erythematosus:


exanthema, pruritus, lupus-like rash, heliotrope rash, seizures

MGI Mouse Phenotypes related to Systemic Lupus Erythematosus:

46 (showing 9, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 C4B CR2 CTLA4 DNASE1 ENG FCGR2A
2 homeostasis/metabolism MP:0005376 10.15 C4B CR2 CTLA4 DNASE1 ENG FCGR2B
3 immune system MP:0005387 10.13 BANK1 C4B CR2 CTLA4 DNASE1 FCGR2A
4 cardiovascular system MP:0005385 10.11 CTLA4 ENG FCGR2B PDCD1 PTPN22 TLR5
5 digestive/alimentary MP:0005381 10.03 C4B CTLA4 ENG FCGR2B PTPN22 TNF
6 mortality/aging MP:0010768 9.97 C4B CR2 CTLA4 DNASE1 ENG FCGR2A
7 liver/biliary system MP:0005370 9.86 C4B CTLA4 FCGR2B PDCD1 PTPN22 TLR5
8 renal/urinary system MP:0005367 9.56 DNASE1 FCGR2B PDCD1 PTPN22 STAT4 TREX1
9 respiratory system MP:0005388 9.23 CTLA4 ENG FCGR2B PDCD1 PTPN22 TLR5

Drugs & Therapeutics for Systemic Lupus Erythematosus

Drugs for Systemic Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 369, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4,Phase 1,Early Phase 1 79902-63-9 54454
2
4-Aminopyridine Approved Phase 4 504-24-5 1727
3
Everolimus Approved Phase 4,Phase 2 159351-69-6 6442177
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
6
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 128794-94-5 5281078
7
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
8
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
9
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53-03-2 5865
10
Sirolimus Approved, Investigational Phase 4,Phase 2 53123-88-9 5284616 6436030 46835353
11
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
12
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 50-18-0, 6055-19-2 2907
13
belimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 356547-88-1 5957 10451420
14
Pioglitazone Approved, Investigational Phase 4,Phase 1,Phase 2 111025-46-8 4829
15
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 118-42-3 3652
16
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 50-78-2 2244
17
Azathioprine Approved Phase 4,Phase 3,Phase 2,Phase 1 446-86-6 2265
18
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
19
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
20
Lenalidomide Approved Phase 4 191732-72-6 216326
21
Sulfamethoxazole Approved Phase 4 723-46-6 5329
22
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
23
Thioguanine Approved Phase 4 154-42-7 2723601
24
Metformin Approved Phase 4 657-24-9 14219 4091
25
Calcitriol Approved, Nutraceutical Phase 4,Phase 2 32222-06-3 134070 5280453
26
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
28
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
29
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 1,Not Applicable 50-14-6 5280793
30
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 1406-16-2
31 Anticholesteremic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
32 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
33 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
34 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
35 Hypolipidemic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
36 Lipid Regulating Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
37 Rosuvastatin Calcium Phase 4,Phase 3,Phase 2,Phase 1 147098-20-2
38 Vaccines Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Potassium Channel Blockers Phase 4
40 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Antifungal Agents Phase 4,Phase 2,Phase 1,Not Applicable
44 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Antilymphocyte Serum Phase 4,Phase 2,Phase 1,Not Applicable
47 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Antitubercular Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
51 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
52 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
53 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
54 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
55 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
56 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
57 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
58 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
59 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
60 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
61 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
62 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
63 Prednisolone phosphate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
64 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
65 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
66 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
67 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
68 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
69 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
70 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
71 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
72 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
73 Atorvastatin Calcium Phase 4,Phase 2,Phase 3,Phase 1 134523-03-8
74 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
75 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
76 Autoantibodies Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
77 Cyclosporins Phase 4,Phase 2,Phase 1,Not Applicable
78 Vasoconstrictor Agents Phase 4,Phase 2
79 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 2,Phase 3
80 Hypoglycemic Agents Phase 4,Phase 1,Phase 2
81 Antimalarials Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
82 Antiparasitic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
83 Antiprotozoal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
84 Diphosphonates Phase 4
85 Hydroxycholecalciferols Phase 4
86 Ibandronic acid Phase 4
87 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
88 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
89 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
90 Antipyretics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
91 Cyclooxygenase Inhibitors Phase 4,Phase 1,Not Applicable
92 Fibrinolytic Agents Phase 4,Phase 1,Phase 2,Not Applicable
93 Platelet Aggregation Inhibitors Phase 4,Phase 1,Phase 2,Not Applicable
94 Adrenocorticotropic Hormone Phase 4
95 beta-endorphin Phase 4
96 Melanocyte-Stimulating Hormones Phase 4
97 Estrogens, Conjugated (USP) Phase 4,Phase 3
98 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
99 Antimitotic Agents Phase 4,Phase 2
100 Antineoplastic Agents, Phytogenic Phase 4,Phase 2
101 Anti-Asthmatic Agents Phase 4,Phase 1
102 Bronchodilator Agents Phase 4
103 Phosphodiesterase 3 Inhibitors Phase 4
104 Phosphodiesterase Inhibitors Phase 4,Not Applicable
105 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1
106 Vasodilator Agents Phase 4,Phase 2,Not Applicable
107 Angiogenesis Inhibitors Phase 4,Phase 2
108 Angiogenesis Modulating Agents Phase 4,Phase 2
109 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 1,Phase 2
110 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
111 Vitamin B Complex Phase 4,Phase 3,Phase 2
112 6-Mercaptopurine Phase 4,Phase 2
113 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
114 Ergocalciferols Phase 4,Phase 2,Phase 1,Not Applicable
115 Antidepressive Agents Phase 4,Not Applicable
116 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
117 Neurotransmitter Uptake Inhibitors Phase 4,Not Applicable
118 Psychotropic Drugs Phase 4,Not Applicable
119 Serotonin Agents Phase 4,Not Applicable
120 Serotonin Uptake Inhibitors Phase 4,Not Applicable
121 Renal Agents Phase 4
122 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
123 Lubricant Eye Drops Phase 4
124 Omega 3 Fatty Acid Nutraceutical Phase 4,Phase 2,Not Applicable
125 Folate Nutraceutical Phase 4,Phase 3,Phase 2
126 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2
127 Calciferol Nutraceutical Phase 4,Phase 2,Phase 1,Not Applicable
128 Vitamin D2 Nutraceutical Phase 4,Phase 2,Phase 1,Not Applicable
129
Serotonin Investigational, Nutraceutical Phase 4,Not Applicable 50-67-9 5202
130
Ezetimibe Approved Phase 3,Early Phase 1 163222-33-1 150311
131
Benzocaine Approved, Investigational Phase 3,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
132
Methotrexate Approved Phase 3,Phase 1,Phase 2 1959-05-2, 59-05-2 126941