Systemic Lupus Erythematosus 1 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Systemic Lupus Erythematosus 1

MalaCards integrated aliases for Systemic Lupus Erythematosus 1:

Name: Systemic Lupus Erythematosus 1 ⁵⁸ ⁷⁶ ³⁰

Systemic Lupus Erythematosus, Resistance to ⁵⁸ ¹³

Sleb1 ⁵⁸ ⁷⁶

Systemic Lupus Erythematosus, Susceptibility to, 1 ⁵⁸

Lupus Erythematosus, Systemic, Type 1 ⁴¹

Lupus Erythematosus, Systemic ⁷⁴

Systemic Lupus Erythematosus ⁵⁸

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Bone diseases Immune diseases Nephrological diseases Skin diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁸ 601744

MeSH ⁴⁵ D008180

MedGen ⁴³ C1864265 C1866373

UMLS ⁷⁴ C0024141

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Summaries for Systemic Lupus Erythematosus 1

UniProtKB/Swiss-Prot : ⁷⁶ Systemic lupus erythematosus 1: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

MalaCards based summary : Systemic Lupus Erythematosus 1, also known as systemic lupus erythematosus, resistance to, is related to systemic lupus erythematosus 16 and systemic lupus erythematosus 2, and has symptoms including seizures and pruritus. An important gene associated with Systemic Lupus Erythematosus 1 is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and TRAF Pathway. Affiliated tissues include bone, skin and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Description from OMIM: 601744

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Related Diseases for Systemic Lupus Erythematosus 1

Diseases in the Lupus Erythematosus family:

Systemic Lupus Erythematosus	Systemic Lupus Erythematosus 15
Systemic Lupus Erythematosus 1	Systemic Lupus Erythematosus 2
Systemic Lupus Erythematosus 3	Systemic Lupus Erythematosus 4
Systemic Lupus Erythematosus 5	Systemic Lupus Erythematosus 6
Systemic Lupus Erythematosus 7	Systemic Lupus Erythematosus 8
Systemic Lupus Erythematosus 9	Systemic Lupus Erythematosus 10
Systemic Lupus Erythematosus 11	Systemic Lupus Erythematosus 12
Systemic Lupus Erythematosus 13	Systemic Lupus Erythematosus 14
Systemic Lupus Erythematosus 16

Diseases related to Systemic Lupus Erythematosus 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1157)

#	Related Disease	Score
1	systemic lupus erythematosus 16	13.0
2	systemic lupus erythematosus 2	12.8
3	systemic lupus erythematosus 10	12.8
4	systemic lupus erythematosus 6	12.8
5	systemic lupus erythematosus 9	12.7
6	systemic lupus erythematosus 11	12.7
7	pediatric systemic lupus erythematosus	12.6
8	systemic lupus erythematosus 3	12.6
9	systemic lupus erythematosus 4	12.6
10	systemic lupus erythematosus 5	12.6
11	systemic lupus erythematosus 7	12.6
12	systemic lupus erythematosus 12	12.6
13	neonatal systemic lupus erythematosus	12.5
14	systemic lupus erythematosus with hemolytic anemia 1	12.5
15	systemic lupus erythematosus 15	12.4
16	systemic lupus erythematosus with nephritis 1	12.4
17	systemic lupus erythematosus with nephritis 2	12.4
18	systemic lupus erythematosus with nephritis 3	12.4
19	systemic lupus erythematosus 8	12.4
20	systemic lupus erythematosus 13	12.4
21	systemic lupus erythematosus 14	12.4
22	neonatal lupus erythematosus	12.3
23	vitiligo-associated multiple autoimmune disease susceptibility 1	12.1
24	mixed connective tissue disease	11.8
25	c1q deficiency	11.8
26	sjogren syndrome	11.7
27	drug-induced lupus erythematosus	11.6
28	macrophage activation syndrome	11.6
29	pure red-cell aplasia	11.6
30	cutaneous lupus erythematosus	11.6
31	anemia, autoimmune hemolytic	11.6
32	complement component 2 deficiency	11.6
33	epidermolysis bullosa acquisita	11.6
34	renal tubular acidosis, distal	11.6
35	jaccoud's syndrome	11.6
36	complement component c1s deficiency	11.6
37	rapidly progressive glomerulonephritis	11.6
38	sneddon syndrome	11.6
39	glomerulopathy with fibronectin deposits 2	11.6
40	complement component 3 deficiency, autosomal recessive	11.6
41	lupus erythematosus tumidus	11.6
42	spondyloenchondrodysplasia	11.6
43	pseudo-torch syndrome 1	11.2
44	chilblain lupus 1	11.2
45	autoimmune disease 6	11.2
46	chilblain lupus 2	11.2
47	aicardi-goutieres syndrome	11.2
48	autoimmune inner ear disease	11.2
49	c1q nephropathy	11.2
50	insulin-resistance type b	11.2

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus 1:

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Symptoms & Phenotypes for Systemic Lupus Erythematosus 1

Clinical features from OMIM:

601744

UMLS symptoms related to Systemic Lupus Erythematosus 1:

seizures, pruritus

GenomeRNAi Phenotypes related to Systemic Lupus Erythematosus 1 according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-139	9.28	MAPK1 TLR5
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-148	9.28	TLR5
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-167	9.28	TLR5
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-204	9.28	TLR5
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-206	9.28	TLR5
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-213	9.28	TLR5
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-55	9.28	MAPK1
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-60	9.28	MAPK1

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Drugs & Therapeutics for Systemic Lupus Erythematosus 1

Search Clinical Trials , NIH Clinical Center for Systemic Lupus Erythematosus 1

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

azathioprine

cyclosporine

hydroxychloroquine

hydroxychloroquine sulfate

triamcinolone

triamcinolone acetonide

triamcinolone acetonide pwdr

triamcinolone diacetate

triamcinolone hexacetonide

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Genetic Tests for Systemic Lupus Erythematosus 1

Genetic tests related to Systemic Lupus Erythematosus 1:

#	Genetic test	Affiliating Genes
1	Systemic Lupus Erythematosus 1 ³⁰	TLR5

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Anatomical Context for Systemic Lupus Erythematosus 1

MalaCards organs/tissues related to Systemic Lupus Erythematosus 1:

⁴²

Bone, Skin, Kidney, Bone Marrow

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Publications for Systemic Lupus Erythematosus 1

Articles related to Systemic Lupus Erythematosus 1:

#	Title	Authors	Year
1	Genetic analysis of systemic lupus erythematosus: 1. Detection of disease-associated variant proteins by two-dimensional gel electrophoresis. ( 3359604 )	Morito F....Yamaguchi M.	1988
2	Aseptic bone necrosis in systemic lupus erythematosus. 1. Report of a case involving four joints. 2. The result of x-ray examination of 22 other cases of lupus erythematosus. ( 6006860 )	Matsumoto J....Mikami R.	1966

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Genes for Systemic Lupus Erythematosus 1

Genes related to Systemic Lupus Erythematosus 1 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TLR5	Toll Like Receptor 5	Protein Coding	668.29	Molecular basis known ⁵⁸ Genetic Tests ³⁰ Susceptibility factor ⁵⁸ GeneCards inferred via : Disorders (show sections)
2	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	16.91	GeneCards inferred via : Publications (show sections)

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Variations for Systemic Lupus Erythematosus 1

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Expression for Systemic Lupus Erythematosus 1

Search GEO for disease gene expression data for Systemic Lupus Erythematosus 1.

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Pathways for Systemic Lupus Erythematosus 1

Pathways related to Systemic Lupus Erythematosus 1 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Toll-like Receptor Signaling Pathway ³⁸ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁸ Epstein-Barr virus infection ³⁸ Hepatitis B ³⁸ Hepatitis C ³⁸ NOD-like Receptor Signaling Pathways ⁶⁶ Regulation of toll-like receptor signaling pathway ¹	12.5	MAPK1 TLR5
2	TRAF Pathway ⁶⁵ Show member pathways 14-3-3 Induced Apoptosis ⁶⁵ TNF Superfamily Pathway ⁶⁵ Toll-Like Receptors Pathway ⁶⁵	11.96	MAPK1 TLR5
3	Th17 cell differentiation ³⁸ Show member pathways IL-22 Pathway ⁶⁵ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease (IBD) ³⁸ Th1 and Th2 cell differentiation ³⁸	11.94	MAPK1 TLR5
4	VEGF Pathway (Qiagen) ⁶⁵ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁵ Development VEGF-family signaling ²³ Neurophilin interactions with VEGF and VEGFR ⁶⁷ VEGF Pathway ⁶⁵	11.74	MAPK1 TLR5
5	IL-17 Family Signaling Pathways ⁶⁶ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁸ Interleukin-17 signaling ⁶⁷ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	11.65	MAPK1 TLR5
6	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²³ Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²³	11.56	MAPK1 TLR5
7	Diseases associated with the TLR signaling cascade ⁶⁷ Show member pathways Diseases of Immune System ⁶⁷ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁷ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁷ IRAK4 deficiency (TLR2/4) ⁶⁷ IRAK4 deficiency (TLR5) ⁶⁷ MyD88 deficiency (TLR2/4) ⁶⁷ MyD88 deficiency (TLR5) ⁶⁷ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	11.54	MAPK1 TLR5
8	IL-1 Family Signaling Pathways ⁶⁶ Show member pathways Immune response IL-1 signaling pathway ²³ Mucin expression in CF via TLRs, EGFR signaling pathways ²³	11.4	MAPK1 TLR5
9	Colorectal Cancer Metastasis ⁶⁵	11.17	MAPK1 TLR5
10	Salmonella infection (KEGG) ³⁸	10.56	MAPK1 TLR5

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GO Terms for Systemic Lupus Erythematosus 1

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Sources for Systemic Lupus Erythematosus 1

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Systemic Lupus Erythematosus 1 (SLEB1)

Aliases & Classifications for Systemic Lupus Erythematosus 1

MalaCards integrated aliases for Systemic Lupus Erythematosus 1:

Classifications:

External Ids:

Summaries for Systemic Lupus Erythematosus 1

Related Diseases for Systemic Lupus Erythematosus 1

Diseases in the Lupus Erythematosus family:

Diseases related to Systemic Lupus Erythematosus 1 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus 1:

Symptoms & Phenotypes for Systemic Lupus Erythematosus 1

Clinical features from OMIM:

UMLS symptoms related to Systemic Lupus Erythematosus 1:

GenomeRNAi Phenotypes related to Systemic Lupus Erythematosus 1 according to GeneCards Suite gene sharing:

Drugs & Therapeutics for Systemic Lupus Erythematosus 1

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Genetic Tests for Systemic Lupus Erythematosus 1

Genetic tests related to Systemic Lupus Erythematosus 1:

Anatomical Context for Systemic Lupus Erythematosus 1

MalaCards organs/tissues related to Systemic Lupus Erythematosus 1:

Publications for Systemic Lupus Erythematosus 1

Articles related to Systemic Lupus Erythematosus 1:

Genes for Systemic Lupus Erythematosus 1

Genes related to Systemic Lupus Erythematosus 1 (1 elite genes):

Variations for Systemic Lupus Erythematosus 1

Expression for Systemic Lupus Erythematosus 1

Pathways for Systemic Lupus Erythematosus 1

Pathways related to Systemic Lupus Erythematosus 1 according to GeneCards Suite gene sharing:

GO Terms for Systemic Lupus Erythematosus 1

Sources for Systemic Lupus Erythematosus 1

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :