Systemic Lupus Erythematosus 1 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Systemic Lupus Erythematosus 1

MalaCards integrated aliases for Systemic Lupus Erythematosus 1:

Name: Systemic Lupus Erythematosus 1 ⁵⁷ ⁷⁵ ²⁹

Systemic Lupus Erythematosus, Resistance to ⁵⁷ ¹³

Sleb1 ⁵⁷ ⁷⁵

Systemic Lupus Erythematosus, Susceptibility to, 1 ⁵⁷

Lupus Erythematosus, Systemic, Type 1 ⁴⁰

Lupus Erythematosus, Systemic ⁷³

Systemic Lupus Erythematosus ⁵⁷

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Bone diseases Immune diseases Nephrological diseases Skin diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 601744

MedGen ⁴² C1866373 C1864265

MeSH ⁴⁴ D008180

UMLS ⁷³ C0024141

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Summaries for Systemic Lupus Erythematosus 1

UniProtKB/Swiss-Prot : ⁷⁵ Systemic lupus erythematosus 1: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

MalaCards based summary : Systemic Lupus Erythematosus 1, also known as systemic lupus erythematosus, resistance to, is related to systemic lupus erythematosus 16 and systemic lupus erythematosus 2, and has symptoms including seizures and pruritus. An important gene associated with Systemic Lupus Erythematosus 1 is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and TRAF Pathway. Affiliated tissues include skin, bone and kidney, and related phenotype is adipose tissue.

Description from OMIM: 601744

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Related Diseases for Systemic Lupus Erythematosus 1

Diseases in the Lupus Erythematosus family:

Systemic Lupus Erythematosus	Systemic Lupus Erythematosus 15
Systemic Lupus Erythematosus 1	Systemic Lupus Erythematosus 2
Systemic Lupus Erythematosus 3	Systemic Lupus Erythematosus 4
Systemic Lupus Erythematosus 5	Systemic Lupus Erythematosus 6
Systemic Lupus Erythematosus 7	Systemic Lupus Erythematosus 8
Systemic Lupus Erythematosus 9	Systemic Lupus Erythematosus 10
Systemic Lupus Erythematosus 11	Systemic Lupus Erythematosus 12
Systemic Lupus Erythematosus 13	Systemic Lupus Erythematosus 14
Systemic Lupus Erythematosus 16

Diseases related to Systemic Lupus Erythematosus 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1060)

#	Related Disease	Score
1	systemic lupus erythematosus 16	12.9
2	systemic lupus erythematosus 2	12.8
3	systemic lupus erythematosus 10	12.8
4	systemic lupus erythematosus 6	12.7
5	systemic lupus erythematosus 9	12.7
6	systemic lupus erythematosus 11	12.6
7	pediatric systemic lupus erythematosus	12.6
8	systemic lupus erythematosus 3	12.5
9	systemic lupus erythematosus 4	12.5
10	systemic lupus erythematosus 5	12.5
11	systemic lupus erythematosus 7	12.5
12	systemic lupus erythematosus 12	12.5
13	neonatal systemic lupus erythematosus	12.5
14	systemic lupus erythematosus with hemolytic anemia 1	12.5
15	systemic lupus erythematosus 15	12.4
16	systemic lupus erythematosus with nephritis 1	12.4
17	systemic lupus erythematosus with nephritis 2	12.4
18	systemic lupus erythematosus with nephritis 3	12.4
19	systemic lupus erythematosus 8	12.4
20	systemic lupus erythematosus 13	12.4
21	systemic lupus erythematosus 14	12.4
22	neonatal lupus erythematosus	12.2
23	vitiligo-associated multiple autoimmune disease susceptibility 1	12.0
24	c1q deficiency	11.8
25	mixed connective tissue disease	11.8
26	sjogren syndrome	11.6
27	drug-induced lupus erythematosus	11.6
28	macrophage activation syndrome	11.6
29	pure red-cell aplasia	11.6
30	cutaneous lupus erythematosus	11.6
31	hypogonadotropic hypogonadism	11.6
32	complement component 2 deficiency	11.6
33	epidermolysis bullosa acquisita	11.6
34	renal tubular acidosis, distal	11.6
35	undifferentiated connective tissue disease	11.5
36	complement component c1s deficiency	11.5
37	rapidly progressive glomerulonephritis	11.5
38	sneddon syndrome	11.5
39	glomerulopathy with fibronectin deposits 2	11.5
40	complement component 3 deficiency, autosomal recessive	11.5
41	lupus erythematosus tumidus	11.5
42	spondyloenchondrodysplasia	11.5
43	pseudo-torch syndrome 1	11.2
44	chilblain lupus 1	11.2
45	autoimmune disease 6	11.2
46	chilblain lupus 2	11.2
47	aicardi-goutieres syndrome	11.2
48	autoimmune inner ear disease	11.2
49	c1q nephropathy	11.2
50	insulin-resistance type b	11.2

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus 1:

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Symptoms & Phenotypes for Systemic Lupus Erythematosus 1

Clinical features from OMIM:

601744

UMLS symptoms related to Systemic Lupus Erythematosus 1:

seizures, pruritus

MGI Mouse Phenotypes related to Systemic Lupus Erythematosus 1:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	adipose tissue	MP:0005375	8.62	MAPK8 TLR5

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Drugs & Therapeutics for Systemic Lupus Erythematosus 1

Search Clinical Trials , NIH Clinical Center for Systemic Lupus Erythematosus 1

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

azathioprine

cyclosporine

hydroxychloroquine

hydroxychloroquine sulfate

triamcinolone

triamcinolone acetonide

triamcinolone acetonide pwdr

triamcinolone diacetate

triamcinolone hexacetonide

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Genetic Tests for Systemic Lupus Erythematosus 1

Genetic tests related to Systemic Lupus Erythematosus 1:

#	Genetic test	Affiliating Genes
1	Systemic Lupus Erythematosus 1 ²⁹	TLR5

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Anatomical Context for Systemic Lupus Erythematosus 1

MalaCards organs/tissues related to Systemic Lupus Erythematosus 1:

⁴¹

Skin, Bone, Kidney, Bone Marrow, B Cells, Heart, Testes

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Publications for Systemic Lupus Erythematosus 1

Articles related to Systemic Lupus Erythematosus 1:

#	Title	Authors	Year
1	Genetic analysis of systemic lupus erythematosus: 1. Detection of disease-associated variant proteins by two-dimensional gel electrophoresis. ( 3359604 )	Morito F....Yamaguchi M.	1988
2	Aseptic bone necrosis in systemic lupus erythematosus. 1. Report of a case involving four joints. 2. The result of x-ray examination of 22 other cases of lupus erythematosus. ( 6006860 )		1966

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Genes for Systemic Lupus Erythematosus 1

Genes related to Systemic Lupus Erythematosus 1 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TLR5	Toll Like Receptor 5	Protein Coding	668.29	Molecular basis known ⁵⁷ Genetic Tests ²⁹ Susceptibility factor ⁵⁷ GeneCards inferred via : Disorders (show sections)
2	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	16.91	GeneCards inferred via : Publications (show sections)

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Variations for Systemic Lupus Erythematosus 1

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Expression for Systemic Lupus Erythematosus 1

Search GEO for disease gene expression data for Systemic Lupus Erythematosus 1.

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Pathways for Systemic Lupus Erythematosus 1

Pathways related to Systemic Lupus Erythematosus 1 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	12.31	MAPK8 TLR5
2	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	11.94	MAPK8 TLR5
3	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	11.91	MAPK8 TLR5
4	VEGF Pathway (Qiagen) ²² Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴ VEGF Pathway ⁶⁴	11.69	MAPK8 TLR5
5	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	11.59	MAPK8 TLR5
6	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²² Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²²	11.54	MAPK8 TLR5
7	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	11.4	MAPK8 TLR5
8	MAPK Pathway ⁷² Show member pathways Toll-like Receptor Pathway ⁷²	11.05	MAPK8 TLR5
9	Salmonella infection (KEGG) ³⁷	10.56	MAPK8 TLR5

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GO Terms for Systemic Lupus Erythematosus 1

Biological processes related to Systemic Lupus Erythematosus 1 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to lipopolysaccharide	GO:0071222	8.96	MAPK8 TLR5
2	cellular response to mechanical stimulus	GO:0071260	8.62	MAPK8 TLR5

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Sources for Systemic Lupus Erythematosus 1

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Systemic Lupus Erythematosus 1 (SLEB1)

Aliases & Classifications for Systemic Lupus Erythematosus 1

MalaCards integrated aliases for Systemic Lupus Erythematosus 1:

Classifications:

External Ids:

Summaries for Systemic Lupus Erythematosus 1

Related Diseases for Systemic Lupus Erythematosus 1

Diseases in the Lupus Erythematosus family:

Diseases related to Systemic Lupus Erythematosus 1 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus 1:

Symptoms & Phenotypes for Systemic Lupus Erythematosus 1

Clinical features from OMIM:

UMLS symptoms related to Systemic Lupus Erythematosus 1:

MGI Mouse Phenotypes related to Systemic Lupus Erythematosus 1:

Drugs & Therapeutics for Systemic Lupus Erythematosus 1

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Genetic Tests for Systemic Lupus Erythematosus 1

Genetic tests related to Systemic Lupus Erythematosus 1:

Anatomical Context for Systemic Lupus Erythematosus 1

MalaCards organs/tissues related to Systemic Lupus Erythematosus 1:

Publications for Systemic Lupus Erythematosus 1

Articles related to Systemic Lupus Erythematosus 1:

Genes for Systemic Lupus Erythematosus 1

Genes related to Systemic Lupus Erythematosus 1 (1 elite genes):

Variations for Systemic Lupus Erythematosus 1

Expression for Systemic Lupus Erythematosus 1

Pathways for Systemic Lupus Erythematosus 1

Pathways related to Systemic Lupus Erythematosus 1 according to GeneCards Suite gene sharing:

GO Terms for Systemic Lupus Erythematosus 1

Biological processes related to Systemic Lupus Erythematosus 1 according to GeneCards Suite gene sharing:

Sources for Systemic Lupus Erythematosus 1

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :