SLEB2
MCID: SYS038
MIFTS: 23

Systemic Lupus Erythematosus 2 (SLEB2)

Categories: Bone diseases, Genetic diseases, Immune diseases, Nephrological diseases, Rare diseases, Skin diseases

Aliases & Classifications for Systemic Lupus Erythematosus 2

MalaCards integrated aliases for Systemic Lupus Erythematosus 2:

Name: Systemic Lupus Erythematosus 2 58 76 30
Systemic Lupus Erythematosus, Susceptibility to, 2 58 13 74
Sleb2 58 76
Lupus Erythematosus, Systemic, Susceptibility to, Type 2 41

Classifications:



External Ids:

OMIM 58 605218
MeSH 45 D008180
MedGen 43 C1854577
UMLS 74 C1854577

Summaries for Systemic Lupus Erythematosus 2

UniProtKB/Swiss-Prot : 76 Systemic lupus erythematosus 2: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

MalaCards based summary : Systemic Lupus Erythematosus 2, also known as systemic lupus erythematosus, susceptibility to, 2, is related to systemic lupus erythematosus and lupus erythematosus. An important gene associated with Systemic Lupus Erythematosus 2 is PDCD1 (Programmed Cell Death 1), and among its related pathways/superpathways is NF-kappaB Signaling. Affiliated tissues include skin, kidney and bone.

Description from OMIM: 605218

Related Diseases for Systemic Lupus Erythematosus 2

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus 2:



Diseases related to Systemic Lupus Erythematosus 2

Symptoms & Phenotypes for Systemic Lupus Erythematosus 2

Clinical features from OMIM:

605218

Drugs & Therapeutics for Systemic Lupus Erythematosus 2

Search Clinical Trials , NIH Clinical Center for Systemic Lupus Erythematosus 2

Genetic Tests for Systemic Lupus Erythematosus 2

Genetic tests related to Systemic Lupus Erythematosus 2:

# Genetic test Affiliating Genes
1 Systemic Lupus Erythematosus 2 30 PDCD1

Anatomical Context for Systemic Lupus Erythematosus 2

MalaCards organs/tissues related to Systemic Lupus Erythematosus 2:

42
Skin, Kidney, Bone, Bone Marrow, Testes

Publications for Systemic Lupus Erythematosus 2

Articles related to Systemic Lupus Erythematosus 2:

# Title Authors Year
1
Non-Hodgkin's lymphoma in patients with systemic lupus erythematosus: 2 case reports. ( 11975105 )
2002
2
Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. ( 3861745 )
1985
3
The deoxyribonucleic acid (DNA) skin test in systemic lupus erythematosus. 2. Histological findings. ( 127605 )
1975

Variations for Systemic Lupus Erythematosus 2

Expression for Systemic Lupus Erythematosus 2

Search GEO for disease gene expression data for Systemic Lupus Erythematosus 2.

Pathways for Systemic Lupus Erythematosus 2

Pathways related to Systemic Lupus Erythematosus 2 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.14 OAS1 PDCD1

GO Terms for Systemic Lupus Erythematosus 2

Sources for Systemic Lupus Erythematosus 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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