SLEB6
MCID: SYS069
MIFTS: 23

Systemic Lupus Erythematosus 6 (SLEB6)

Categories: Bone diseases, Genetic diseases, Immune diseases, Nephrological diseases, Rare diseases, Skin diseases

Aliases & Classifications for Systemic Lupus Erythematosus 6

MalaCards integrated aliases for Systemic Lupus Erythematosus 6:

Name: Systemic Lupus Erythematosus 6 58 76 30
Sleb6 58 76
Systemic Lupus Erythematosus, Susceptibility to, 6 58
Lupus Erythematosus, Systemic, Type 6 41

Characteristics:

HPO:

33
systemic lupus erythematosus 6:
Inheritance polygenic inheritance


Classifications:



Summaries for Systemic Lupus Erythematosus 6

UniProtKB/Swiss-Prot : 76 Systemic lupus erythematosus 6: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

MalaCards based summary : Systemic Lupus Erythematosus 6, also known as sleb6, is related to systemic lupus erythematosus and lupus erythematosus. An important gene associated with Systemic Lupus Erythematosus 6 is ITGAM (Integrin Subunit Alpha M). Affiliated tissues include skin, kidney and bone, and related phenotypes are arthritis and abnormal renal physiology

Description from OMIM: 609939

Related Diseases for Systemic Lupus Erythematosus 6

Symptoms & Phenotypes for Systemic Lupus Erythematosus 6

Human phenotypes related to Systemic Lupus Erythematosus 6:

33 (show all 10)
# Description HPO Frequency HPO Source Accession
1 arthritis 33 very rare (1%) HP:0001369
2 abnormal renal physiology 33 very rare (1%) HP:0012211
3 abnormality of the nervous system 33 very rare (1%) HP:0000707
4 pericarditis 33 very rare (1%) HP:0001701
5 cutaneous photosensitivity 33 very rare (1%) HP:0000992
6 spontaneous abortion 33 very rare (1%) HP:0005268
7 pleuritis 33 very rare (1%) HP:0002102
8 systemic lupus erythematosus 33 very rare (1%) HP:0002725
9 antinuclear antibody positivity 33 very rare (1%) HP:0003493
10 malar rash 33 very rare (1%) HP:0025300

Clinical features from OMIM:

609939

Drugs & Therapeutics for Systemic Lupus Erythematosus 6

Search Clinical Trials , NIH Clinical Center for Systemic Lupus Erythematosus 6

Genetic Tests for Systemic Lupus Erythematosus 6

Genetic tests related to Systemic Lupus Erythematosus 6:

# Genetic test Affiliating Genes
1 Systemic Lupus Erythematosus 6 30

Anatomical Context for Systemic Lupus Erythematosus 6

MalaCards organs/tissues related to Systemic Lupus Erythematosus 6:

42
Skin, Kidney, Bone, Bone Marrow

Publications for Systemic Lupus Erythematosus 6

Articles related to Systemic Lupus Erythematosus 6:

# Title Authors Year
1
Long-term impact of belimumab on health-related quality of life and fatigue in patients with systemic lupus erythematosus: 6 years of treatment. ( 30320964 )
2018

Variations for Systemic Lupus Erythematosus 6

Expression for Systemic Lupus Erythematosus 6

Search GEO for disease gene expression data for Systemic Lupus Erythematosus 6.

Pathways for Systemic Lupus Erythematosus 6

GO Terms for Systemic Lupus Erythematosus 6

Sources for Systemic Lupus Erythematosus 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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