SLEB6
MCID: SYS069
MIFTS: 25

Systemic Lupus Erythematosus 6 (SLEB6)

Categories: Bone diseases, Genetic diseases, Immune diseases, Nephrological diseases, Rare diseases, Skin diseases

Aliases & Classifications for Systemic Lupus Erythematosus 6

MalaCards integrated aliases for Systemic Lupus Erythematosus 6:

Name: Systemic Lupus Erythematosus 6 57 75 29
Systemic Lupus Erythematous, Association with Susceptibility to, 6 57 13
Sleb6 57 75
Systemic Lupus Erythematosus, Susceptibility to, 6 57
Systemic Lupus Erythematous, Association with 6 57
Lupus Erythematosus, Systemic, Type 6 40

Characteristics:

HPO:

32
systemic lupus erythematosus 6:
Inheritance polygenic inheritance


Classifications:



Summaries for Systemic Lupus Erythematosus 6

UniProtKB/Swiss-Prot : 75 Systemic lupus erythematosus 6: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

MalaCards based summary : Systemic Lupus Erythematosus 6, also known as systemic lupus erythematous, association with susceptibility to, 6, is related to systemic lupus erythematosus and lupus erythematosus. An important gene associated with Systemic Lupus Erythematosus 6 is ITGAM (Integrin Subunit Alpha M). Affiliated tissues include bone, skin and kidney, and related phenotypes are arthritis and abnormal renal physiology

Description from OMIM: 609939

Related Diseases for Systemic Lupus Erythematosus 6

Symptoms & Phenotypes for Systemic Lupus Erythematosus 6

Clinical features from OMIM:

609939

Human phenotypes related to Systemic Lupus Erythematosus 6:

32 (show all 10)
# Description HPO Frequency HPO Source Accession
1 arthritis 32 very rare (1%) HP:0001369
2 abnormal renal physiology 32 very rare (1%) HP:0012211
3 abnormality of the nervous system 32 very rare (1%) HP:0000707
4 pericarditis 32 very rare (1%) HP:0001701
5 cutaneous photosensitivity 32 very rare (1%) HP:0000992
6 spontaneous abortion 32 very rare (1%) HP:0005268
7 pleuritis 32 very rare (1%) HP:0002102
8 systemic lupus erythematosus 32 very rare (1%) HP:0002725
9 antinuclear antibody positivity 32 very rare (1%) HP:0003493
10 malar rash 32 very rare (1%) HP:0025300

Drugs & Therapeutics for Systemic Lupus Erythematosus 6

Search Clinical Trials , NIH Clinical Center for Systemic Lupus Erythematosus 6

Genetic Tests for Systemic Lupus Erythematosus 6

Genetic tests related to Systemic Lupus Erythematosus 6:

# Genetic test Affiliating Genes
1 Systemic Lupus Erythematosus 6 29 ITGAM

Anatomical Context for Systemic Lupus Erythematosus 6

MalaCards organs/tissues related to Systemic Lupus Erythematosus 6:

41
Bone, Skin, Kidney, Bone Marrow, Myeloid

Publications for Systemic Lupus Erythematosus 6

Articles related to Systemic Lupus Erythematosus 6:

# Title Authors Year
1
Long-term impact of belimumab on health-related quality of life and fatigue in patients with systemic lupus erythematosus: 6 years of treatment. ( 30320964 )
2018

Variations for Systemic Lupus Erythematosus 6

Expression for Systemic Lupus Erythematosus 6

Search GEO for disease gene expression data for Systemic Lupus Erythematosus 6.

Pathways for Systemic Lupus Erythematosus 6

GO Terms for Systemic Lupus Erythematosus 6

Sources for Systemic Lupus Erythematosus 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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