MCID: SYS066
MIFTS: 27

Systemic Polyarteritis Nodosa

Categories: Bone diseases, Cardiovascular diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Systemic Polyarteritis Nodosa

MalaCards integrated aliases for Systemic Polyarteritis Nodosa:

Name: Systemic Polyarteritis Nodosa 59
Systemic Periarteritis Nodosa 59
Polyarteritis Nodosa 72
Systemic Pan 59

Characteristics:

Orphanet epidemiological data:

59
systemic polyarteritis nodosa
Inheritance: Not applicable;

Classifications:



External Ids:

ICD10 via Orphanet 34 M30.0
UMLS via Orphanet 73 C0031036
Orphanet 59 ORPHA439762
UMLS 72 C0031036

Summaries for Systemic Polyarteritis Nodosa

MalaCards based summary : Systemic Polyarteritis Nodosa, also known as systemic periarteritis nodosa, is related to polyarteritis nodosa and vasculitis. The drugs Cyclophosphamide and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and appendix.

Related Diseases for Systemic Polyarteritis Nodosa

Diseases in the Polyarteritis Nodosa family:

Systemic Polyarteritis Nodosa Secondary Polyarteritis Nodosa
Primary Polyarteritis Nodosa

Diseases related to Systemic Polyarteritis Nodosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 polyarteritis nodosa 10.7
2 vasculitis 10.5
3 hepatitis b 10.2
4 churg-strauss syndrome 10.2
5 purpura 10.2
6 lupus erythematosus 10.2
7 allergic angiitis 10.2
8 eosinophilic granulomatosis with polyangiitis 10.2
9 systemic lupus erythematosus 10.1
10 keratosis 10.0
11 autoimmune disease 10.0
12 temporal arteritis 10.0
13 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
14 membranous nephropathy 10.0
15 exanthem 10.0
16 mastitis 10.0
17 hemiplegia 10.0
18 mononeuropathy 10.0
19 cholestasis 10.0
20 urticaria 10.0
21 rheumatic disease 10.0
22 mononeuritis multiplex 10.0
23 viral hepatitis 10.0
24 enthesopathy 10.0
25 hepatitis 10.0
26 polyclonal hypergammaglobulinemia 10.0
27 cryoglobulinemia 10.0
28 glomerulonephritis 10.0
29 adenocarcinoma 10.0
30 acute kidney failure 10.0
31 gastric adenocarcinoma 10.0
32 pyoderma 10.0
33 calciphylaxis 10.0
34 acquired immunodeficiency syndrome 10.0
35 connective tissue disease 10.0
36 juvenile rheumatoid arthritis 10.0
37 pyoderma gangrenosum 10.0
38 cutaneous polyarteritis nodosa 10.0
39 microscopic polyangiitis 10.0
40 foot drop 10.0
41 hypoglycemia 9.7

Comorbidity relations with Systemic Polyarteritis Nodosa via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Deficiency Anemia Heart Disease

Graphical network of the top 20 diseases related to Systemic Polyarteritis Nodosa:



Diseases related to Systemic Polyarteritis Nodosa

Symptoms & Phenotypes for Systemic Polyarteritis Nodosa

Drugs & Therapeutics for Systemic Polyarteritis Nodosa

Drugs for Systemic Polyarteritis Nodosa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
2
Azathioprine Approved Phase 4 446-86-6 2265
3
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
4
leucovorin Approved Phase 4 58-05-9 143 6006
5
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
8
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
9
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
10
Mycophenolic acid Approved Phase 4 24280-93-1 446541
11
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
12
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
13 Alkylating Agents Phase 4
14 Immunosuppressive Agents Phase 4
15 Antimetabolites Phase 4
16 Antirheumatic Agents Phase 4
17 Antineoplastic Agents, Alkylating Phase 4
18 Antimetabolites, Antineoplastic Phase 4
19 Folic Acid Antagonists Phase 4
20 Vitamin B9 Phase 4
21 Nucleic Acid Synthesis Inhibitors Phase 4
22 Vitamin B Complex Phase 4
23 Folate Phase 4
24 Dermatologic Agents Phase 4
25 Hormone Antagonists Phase 4
26 Hormones Phase 4
27 Neuroprotective Agents Phase 4
28 Prednisolone acetate Phase 4
29 Methylprednisolone Acetate Phase 4
30 Anti-Inflammatory Agents Phase 4
31 glucocorticoids Phase 4
32 Gastrointestinal Agents Phase 4
33 Antiemetics Phase 4
34 Protective Agents Phase 4
35 Anti-Infective Agents Phase 4
36 Antineoplastic Agents, Hormonal Phase 4
37 Autonomic Agents Phase 4
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
39 Anti-Bacterial Agents Phase 4
40 Antitubercular Agents Phase 4
41 Antibiotics, Antitubercular Phase 4
42
Lamivudine Approved, Investigational Phase 2 134678-17-4 60825
43
Colchicine Approved Phase 2 64-86-8 6167 2833
44
Dapsone Approved, Investigational Phase 2 80-08-0 2955
45
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
46
Ethanol Approved Phase 2 64-17-5 702
47 Immunologic Factors Phase 2
48 Reverse Transcriptase Inhibitors Phase 2
49 Anti-HIV Agents Phase 2
50 Antiviral Agents Phase 2

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 CHUSPAN PAN BP Treatment of Polyarteritis Nodosa and Microscopic Polyangiitis Without Poor-Prognosis Factors a Prospective Randomized Study in 125 Patients Unknown status NCT00400075 Phase 4 azathioprine;cyclophosphamide
2 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Comparison of Two Strategies Combining Steroids With or Without Immunosuppressants Completed NCT00307671 Phase 4 prednisone, methylprednisolone,cyclophosphamides;Cyclophosphamide, Azathioprine,prednisone,methylprednisolone;Mycophenolate mofetil,methotrexate
3 Evaluation of a New Treatment Strategy for Patients With Microscopic Polyangiitis, Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome) Without Poor Prognosis Factors Completed NCT00647166 Phase 3 corticosteroid and azathioprine;corticosteroid and placebo
4 Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing Vasculitides. A Randomized Controlled Trial. Unknown status NCT00751517 Phase 2 Methotrexate;Cyclophosphamide
5 Lamivudine for Chronic Hepatitis B Completed NCT00001457 Phase 2 Lamivudine
6 An Open Trial of the Efficacy of Glucocorticoids and Methotrexate (MTX) in the Treatment of Systemic Vasculitis Completed NCT00001256 Phase 2 prednisone and methotrexate
7 A Randomized Multicenter Study for Isolated Skin Vasculitis Recruiting NCT02939573 Phase 2 Colchicine;Dapsone;Azathioprine
8 Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis Recruiting NCT03482479 Phase 2 Naltrexone Hydrochloride
9 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
10 ACR/EULAR Endorsed Study to Develop New Diagnostic and Classification Criteria for Primary Systemic Vasculitis Unknown status NCT01066208
11 Educational Needs of Patients With Systemic Vasculitis- an International Survey Completed NCT02190929
12 Illness Perception, Fatigue, and Function in Systemic Vasculitis (The VCRC Vasculitis Perception (VIP) Study) Completed NCT02190916
13 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
14 The Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
15 Impact of Vasculitis on Employment and Income. An Online Survey of Participants in the VCRC Patient Contact Registry Completed NCT02476292
16 A Staged Therapeutic Approach Using Cyclophosphamide and Methotrexate in the Treatment of Wegener's Granulomatosis and Related Vasculitides Completed NCT00001473
17 Longitudinal Protocol of Polyarteritis Nodosa Recruiting NCT00315406
18 Clinical Transcriptomics in Systemic Vasculitis (CUTIS) Recruiting NCT03004326
19 VCRC Genetic Repository One-Time DNA Protocol Recruiting NCT01241305
20 VCRC Tissue Biorepository Collection Protocol Recruiting NCT02967068
21 The Vasculitis Pregnancy Registry (V-PREG) Recruiting NCT02593565
22 Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis Recruiting NCT02257866
23 Chronic Childhood Vasculitis: Characterizing the Individual Rare Diseases to Improve Patient Outcomes Recruiting NCT02006134
24 VCRC Validation of Patient-Reported Diagnostic Data Enrolling by invitation NCT02190942

Search NIH Clinical Center for Systemic Polyarteritis Nodosa

Genetic Tests for Systemic Polyarteritis Nodosa

Anatomical Context for Systemic Polyarteritis Nodosa

MalaCards organs/tissues related to Systemic Polyarteritis Nodosa:

41
Skin, Bone, Appendix

Publications for Systemic Polyarteritis Nodosa

Articles related to Systemic Polyarteritis Nodosa:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Adenosine Deaminase 2 Deficiency 38
31393689 2019
2
[Cutaneous alterations in vasculitides : Part 2: Special aspects of diseases of large, medium and small vessels]. 38
31300830 2019
3
Analysis of the clinical characteristics and follow-up study of children with cutaneous polyarteritis nodosa. 38
31237213 2019
4
[A Case of Systemic Polyarteritis Nodosa Presenting with Scrotal Pain]. 38
31247691 2019
5
Digital Gangrene in a Dialysis Patient Due to Calciphylaxis and Systemic Polyarteritis Nodosa: A Diagnostic Dilemma. 38
30983759 2019
6
Cutaneous Polyarteritis Nodosa Presenting Atypically with Severe Pharyngeal Ulceration. 38
31019829 2019
7
Recurrent ruptured abdominal aneurysms in polyarteritis nodosa successfully treated with infliximab. 38
31354239 2019
8
Rate of infections in severe necrotising vasculitis patients treated with cyclophosphamide induction therapy: a meta-analysis. 38
29799394 2018
9
Cutaneous Manifestations of Medium- and Large-Vessel Vasculitis. 38
28547523 2017
10
Asymptomatic cutaneous polyarteritis nodosa: treatment options and therapeutic guidelines. 38
28961286 2017
11
Chronic polyarthritis as the first manifestation of childhood systemic polyarteritis nodosa. 38
28444097 2017
12
Childhood-onset systemic polyarteritis nodosa and systemic lupus erythematosus: an overlap syndrome? 38
27914603 2016
13
Monogenic polyarteritis: the lesson of ADA2 deficiency. 38
27609179 2016
14
Epidemiological, clinical and laboratory profiles of cutaneous polyarteritis nodosa patients: Report of 22 cases and literature review. 38
26876385 2016
15
Interchanging Autoimmunity - Lupus Mastitis Coexisting with Systemic Polyarteritis Nodosa. 38
27057023 2016
16
[Cutaneous symptoms of various vasculitides]. 38
26195032 2015
17
[Childhood-onset systemic polyarteritis nodosa and systemic lupus erythematosus: an overlap syndrome?] 38
25824573 2015
18
Polyarteritis nodosa in childhood: recognition of early dermatologic signs may prevent morbidity. 38
23937359 2014
19
Treatment for cutaneous arteritis patients with mononeuritis multiplex and elevated C-reactive protein. 38
24303898 2013
20
Systemic polyarteritis nodosa in the young: a single-center experience over thirty-two years. 38
23754739 2013
21
Cutaneous lymphocytic thrombophilic (macular) arteritis: a distinct entity or an indolent (reparative) stage of cutaneous polyarteritis nodosa? Report of 2 cases of cutaneous arteritis and review of the literature. 38
22688396 2013
22
A review of pediatric vasculitis with a focus on juvenile polyarteritis nodosa. 38
22845169 2012
23
Jejunal obstruction as initial presentation of polyarteritis nodosa in a 13-month-old boy. 38
21763822 2011
24
A case of systemic polyarteritis nodosa involving bronchial artery. 38
21319600 2010
25
Cutaneous polyarteritis nodosa: a comprehensive review. 38
20618492 2010
26
Cutaneous polyarteritis nodosa: a report of 16 cases with clinical and histopathological analysis and a review of the published work. 38
20175828 2010
27
Systemic polyarteritis nodosa mimicking pyoderma gangrenosum in a rare association with small lymphocytic leukaemia/chronic lymphocytic leukaemia. 38
19438540 2009
28
Inflammatory plaque with peripheral nodules: a new specific finding of cutaneous polyarteritis nodosa. 38
19150276 2009
29
Systemic polyarteritis nodosa following hepatitis B vaccination. 38
19046721 2008
30
Comparison of cutaneous manifestations in systemic polyarteritis nodosa and microscopic polyangiitis. 38
18647311 2008
31
A case of systemic polyarteritis nodosa with spermatic cord involvement. 38
18626512 2008
32
Systemic polyarteritis nodosa associated with acute Epstein-Barr virus infection. 38
17205216 2007
33
Successful treatment of pediatric systemic polyarteritis nodosa with cholestatic hepatitis. 38
16362446 2007
34
Diplopia and myalgia: potential heralding symptoms of polyarteritis nodosa. 38
17492845 2007
35
Infantile polyarteritis nodosa presenting as hyponatraemic hypertensive syndrome. 38
16720505 2006
36
Collagenous colitis and cutaneous polyarteritis nodosa in the same patient. 38
14992568 2004
37
[Cutaneous polyarteritis nodosa following hepatitis B vaccination]. 38
12671586 2003
38
The spectrum of cutaneous lesions in rheumatoid arthritis: a clinical and pathological study of 43 patients. 38
12534797 2003
39
Catastrophic visceral involvement secondary to de novo systemic vasculitis in a renal transplant recipient. 38
12018638 2002
40
[Cutaneous polyarteritis nodosa in children: three cases]. 38
11937959 2002
41
Renal angiogram abnormalities in a case of cutaneous polyarteritis nodosa. 38
10671968 2000
42
Pharmacokinetics of teicoplanin during plasma exchange. 38
11856252 1999
43
[Association of acute pericarditis and acute renal insufficiency: causes and prognosis]. 38
9834778 1998
44
Cutaneous polyarteritis nodosa in a child. 38
9572691 1998
45
Circulating soluble adhesion molecules in patients with classical polyarteritis nodosa. 38
9402861 1997
46
Persistence of antineutrophil cytoplasmic antibodies (ANCA) in asymptomatic patients with systemic polyarteritis nodosa or Churg-Strauss syndrome: follow-up of 53 patients. 38
7656465 1995
47
Systemic polyarteritis nodosa as the initial manifestation of a gastric adenocarcinoma. 38
7989904 1994
48
Immunohistochemical characterization of inflammatory cells and immunologic activation markers in muscle and nerve biopsy specimens from patients with systemic polyarteritis nodosa. 38
7912929 1994
49
Antineutrophil cytoplasmic antibodies in systemic polyarteritis nodosa with and without hepatitis B virus infection and Churg-Strauss syndrome--62 patients. 38
7932443 1994
50
Antineutrophil cytoplasm antibodies in systemic polyarteritis nodosa with and without hepatitis B virus infection and Churg-Strauss syndrome--62 patients. 38
7901412 1993

Variations for Systemic Polyarteritis Nodosa

Expression for Systemic Polyarteritis Nodosa

Search GEO for disease gene expression data for Systemic Polyarteritis Nodosa.

Pathways for Systemic Polyarteritis Nodosa

GO Terms for Systemic Polyarteritis Nodosa

Sources for Systemic Polyarteritis Nodosa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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