ATLL
MCID: TCL001
MIFTS: 42

T-Cell Adult Acute Lymphocytic Leukemia (ATLL)

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for T-Cell Adult Acute Lymphocytic Leukemia

MalaCards integrated aliases for T-Cell Adult Acute Lymphocytic Leukemia:

Name: T-Cell Adult Acute Lymphocytic Leukemia 12 15
T-Cell Adult Acute Lymphoblastic Leukemia 70
Adult Precursor T Lymphoblastic Leukemia 12
Acute Adult T-Cell Leukemia-Lymphoma 12
Atll 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5602
NCIt 50 C9142
UMLS 70 C0279592

Summaries for T-Cell Adult Acute Lymphocytic Leukemia

Disease Ontology : 12 An adult acute lymphocytic leukemia occurring in adults and that has material basis in T cells.

MalaCards based summary : T-Cell Adult Acute Lymphocytic Leukemia, also known as t-cell adult acute lymphoblastic leukemia, is related to tropical spastic paraparesis and hepatosplenic t-cell lymphoma. An important gene associated with T-Cell Adult Acute Lymphocytic Leukemia is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Daclizumab and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and lymph node, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Related Diseases for T-Cell Adult Acute Lymphocytic Leukemia

Diseases in the B-Cell Adult Acute Lymphocytic Leukemia family:

T-Cell Adult Acute Lymphocytic Leukemia

Diseases related to T-Cell Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 339)
# Related Disease Score Top Affiliating Genes
1 tropical spastic paraparesis 30.4 IL2 FOXP3 CNTN2
2 hepatosplenic t-cell lymphoma 30.2 TIA1 CD7
3 pericardial effusion 30.2 TNFRSF8 CD4 ALK
4 anemia, autoimmune hemolytic 30.1 CD8A CD5 CD4 CCR6
5 composite lymphoma 30.1 TNFRSF8 TIA1 CD5
6 exanthem 30.1 IL2 CD8A CD4 CCR6
7 t-cell lymphoma, subcutaneous panniculitis-like 30.0 TNFRSF8 TIA1 CD7 ALK
8 lymphoblastic lymphoma 30.0 TNFRSF8 CD8A CD7 CD5 CD4
9 lymphoma 29.9 TNFRSF8 TIA1 IRF4 IL2 CD5 CCR6
10 adult t-cell leukemia 29.8 TNFRSF8 PTHLH JAK3 IRF4 IL2 FOXP3
11 diffuse large b-cell lymphoma 29.8 TNFRSF8 MIR28 IRF4 CD5 ALK
12 anaplastic large cell lymphoma 29.7 TNFRSF8 TIA1 JAK3 CD4 CCR4 ALK
13 cutaneous t cell lymphoma 29.7 TNFRSF8 TIA1 IL2 CCR6 CCR4
14 t-cell lymphoblastic leukemia/lymphoma 29.7 TNFRSF8 PTHLH IRF4 IL2 FOXP3 CREB1
15 b-cell lymphoma 29.7 TNFRSF8 TIA1 IRF4 CD5 ALK
16 lymphoproliferative syndrome 29.6 TNFRSF8 TIA1 IL2 CD5 CCR6 ALK
17 mycosis fungoides 29.5 TNFRSF8 TIA1 IL2 FOXP3 CD7 CCR6
18 lymphoma, hodgkin, classic 29.4 TNFRSF8 TIA1 IRF4 IL2 CCR4 ALK
19 peripheral t-cell lymphoma 29.2 TNFRSF8 TIA1 JAK3 IL2 FOXP3 CD8A
20 mature t-cell and nk-cell lymphoma 28.8 TNFRSF8 TIA1 JAK3 IL2 CD8A CD7
21 sezary's disease 28.1 TNFRSF8 TIA1 JAK3 IRF4 IL2 FOXP3
22 leukemia, t-cell, chronic 10.7
23 pityriasis lichenoides 10.5 TNFRSF8 CD7
24 pityriasis lichenoides et varioliformis acuta 10.5 TNFRSF8 CD7
25 cork-handlers' disease 10.5 CD8A CD4
26 necrotic uveal melanoma 10.5 CD8A CD4
27 american histoplasmosis 10.4 TNFRSF8 CD4
28 early yaws 10.4 CD8A CD4
29 ventilation pneumonitis 10.4 CD8A CD4
30 diffuse infiltrative lymphocytosis syndrome 10.4 CD8A CD4
31 latent syphilis 10.4 CD8A CD4
32 type 1 diabetes mellitus 23 10.4 CD8A CD4
33 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
34 suppurative lymphadenitis 10.4 CD4 CCR6
35 maxillary sinus inverted papilloma 10.4 CD8A ALK
36 lobomycosis 10.4 CD4 CD2
37 lung lymphoma 10.4 TNFRSF8 CD5
38 gastroduodenitis 10.4 CD8A CD4
39 primary syphilis 10.4 CD8A CD4
40 norwegian scabies 10.4 CD8A CD4
41 bird fancier's lung 10.4 CD8A CD4
42 esophageal candidiasis 10.4 CD8A CD4 CCR6
43 pneumonic tularemia 10.4 CD8A CD4 CCR6
44 tularemia 10.4 CD8A CD4 CCR6
45 toxicodendron dermatitis 10.4 IL2 CD8A
46 geotrichosis 10.4 JAK3 CD4
47 iritis 10.4 CD8A CD4 CCR6
48 orbital cellulitis 10.4 TNFRSF8 CD4
49 autoimmune cholangitis 10.4 CD8A CD4 CCR6
50 acute orbital inflammation 10.4 TNFRSF8 CD4

Graphical network of the top 20 diseases related to T-Cell Adult Acute Lymphocytic Leukemia:



Diseases related to T-Cell Adult Acute Lymphocytic Leukemia

Symptoms & Phenotypes for T-Cell Adult Acute Lymphocytic Leukemia

MGI Mouse Phenotypes related to T-Cell Adult Acute Lymphocytic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 CCR4 CCR6 CD4 CD5 CD7 CD8A
2 endocrine/exocrine gland MP:0005379 9.96 ALK CD4 CD7 CD8A CREB1 FOXP3
3 immune system MP:0005387 9.77 CCR4 CCR6 CD4 CD5 CD7 CD8A
4 normal MP:0002873 9.28 ALK CCR6 CD2 CD4 CD5 CD8A

Drugs & Therapeutics for T-Cell Adult Acute Lymphocytic Leukemia

Drugs for T-Cell Adult Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Daclizumab Investigational, Withdrawn Phase 4 152923-56-3
2 Immunosuppressive Agents Phase 4
3 Immunologic Factors Phase 4
4
Lenograstim Approved, Investigational Phase 3 135968-09-1
5 Adjuvants, Immunologic Phase 3
6
nivolumab Approved Phase 2 946414-94-4
7
Etoposide Approved Phase 2 33419-42-0 36462
8
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
9
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
10
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
11
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
12 Antineoplastic Agents, Immunological Phase 2
13 Etoposide phosphate Phase 2
14
Liposomal doxorubicin Phase 2 31703
15
Vincristine Approved, Investigational Phase 1 2068-78-2, 57-22-7 5978
16
Lenalidomide Approved Phase 1 191732-72-6 216326
17
Cortisone Experimental Phase 1 53-06-5 222786
18 Angiogenesis Inhibitors Phase 1
19 Tubulin Modulators Phase 1
20 Antibiotics, Antitubercular Phase 1
21 Hormone Antagonists Phase 1
22 Antimitotic Agents Phase 1
23 Hormones Phase 1
24 Antirheumatic Agents Phase 1
25 glucocorticoids Phase 1
26 Alkylating Agents Phase 1
27 Keratolytic Agents Phase 1
28 Antineoplastic Agents, Hormonal Phase 1
29 Dermatologic Agents Phase 1
30 Anti-Bacterial Agents Phase 1
31 Anti-Inflammatory Agents Phase 1
32 Podophyllotoxin Phase 1 518-28-5

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HTLV-I Associated Adult T-cell Leukaemia/Lymphoma (ATLL) Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
2 Phase III Study of VCAP-AMP-VECP vs. Biweekly CHOP in Aggressive Adult T-cell Leukemia-lymphoma (ATLL): Japan Clinical Oncology Group Study, JCOG9801. Completed NCT00145002 Phase 3 VCAP-AMP-VECP with G-CSF and intrathecal prophylaxis;biweekly-CHOP with G-CSF and intrathecal prophylaxis
3 Phase II Trial of Nivolumab for HTLV-Associated Adult T Cell Leukemia/Lymphoma Completed NCT02631746 Phase 2
4 Multicenter Study of Risk-adapted Treatment for T-lineage ALL of Young Adults (18-59 Years Old): Evaluating the Efficacy of a Nelarabine Based Consolidation and Maintenance in High-risk Patients Recruiting NCT02619630 Phase 2 nelarabine
5 A Phase I/II, Multicenter, Open-Label, Nonrandomized Study to Evaluate the Tolerability and Safety of ASTX660 and the Efficacy at the Recommended Dose of ASTX660 in Patients With Relapsed or Refractory T-Cell Lymphoma Recruiting NCT04362007 Phase 1, Phase 2 ASTX660;ASTX660;ASTX660
6 Brentuximab Vedotin With Cyclophosphamide, Doxorubicin, Etoposide, and Prednisone (BV-CHEP) for the Treatment of Adult T-Cell Leukemia/Lymphoma: A Phase II Trial of the Rare Lymphoma Working Group Recruiting NCT03264131 Phase 2 Brentuximab Vedotin;CHEP
7 A Phase 1 Study of Lenalidomide in Combination With EPOCH Chemotherapy for HTLV-Associated Adult T-Cell Leukemia-Lymphoma (ATLL) Recruiting NCT04301076 Phase 1 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Lenalidomide;Prednisone;Vincristine Sulfate

Search NIH Clinical Center for T-Cell Adult Acute Lymphocytic Leukemia

Genetic Tests for T-Cell Adult Acute Lymphocytic Leukemia

Anatomical Context for T-Cell Adult Acute Lymphocytic Leukemia

MalaCards organs/tissues related to T-Cell Adult Acute Lymphocytic Leukemia:

40
T Cells, Bone Marrow, Lymph Node, Thymus, Skin, Myeloid, B Cells

Publications for T-Cell Adult Acute Lymphocytic Leukemia

Articles related to T-Cell Adult Acute Lymphocytic Leukemia:

(show top 50) (show all 899)
# Title Authors PMID Year
1
Importin β1 regulates cell growth and survival during adult T cell leukemia/lymphoma therapy. 61
32959166 2021
2
Comprehensive genomic analysis identifying heterogeneity in peripheral T-cell lymphoma. 61
33576080 2021
3
Genetic profile of adult T-cell leukemia/lymphoma in Okinawa: Association with prognosis, ethnicity, and HTLV-1 strains. 61
33426772 2021
4
Outcomes of adult T-Cell leukemia/lymphoma with allogeneic stem cell transplantation: single-institution experience. 61
33779474 2021
5
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) versus adult T-cell leukemia/lymphoma (ATLL). 61
33757561 2021
6
Extracellular vesicles from HTLV-1 infected cells modulate target cells and viral spread. 61
33622348 2021
7
Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma. 61
32054656 2021
8
Human T-cell lymphotropic virus HBZ and tax mRNA expression are associated with specific clinicopathological features in adult T-cell leukemia/lymphoma. 61
32973330 2021
9
Cord blood transplantation with a reduced-intensity conditioning regimen using fludarabine and melphalan for adult T-cell leukemia/lymphoma. 61
33594654 2021
10
Novel Mutations in a Lethal Case of Lymphomatous Adult T Cell Lymphoma with Cryptic Myocardial Involvement. 61
33562071 2021
11
Ectonucleotidase CD39 is highly expressed on ATLL cells and is responsible for their immunosuppressive function. 61
32203145 2021
12
[Leukemia associated to human T cell lymphotropic virus type 1 (HTLV-1) infection and intrafamily transmission in Santiago del Estero]. 61
33611254 2021
13
Pathophysiological significance of N-myc downstream-regulated gene 2 in cancer development through protein phosphatase 2A phosphorylation regulation. 61
33128318 2021
14
Global expression of noncoding RNome reveals dysregulation of small RNAs in patients with HTLV-1-associated adult T-cell leukemia: a pilot study. 61
33422115 2021
15
Deciphering microRNA-mRNA regulatory network in adult T-cell leukemia/lymphoma; the battle between oncogenes and anti-oncogenes. 61
33630973 2021
16
A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1. 61
32801340 2021
17
Decrease in naïve T cell production due to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) development. 61
33338979 2021
18
Clinicopathological features of adult T-cell leukemia/lymphoma with HTLV-1-infected Hodgkin and Reed-Sternberg-like cells. 61
33570645 2021
19
The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation. 61
33362245 2020
20
Status of humoral and cellular immune markers in human T-cell lymphotropic virus type 1 (HTLV-1) asymptomatic carriers in northeastern Iran, Mashhad. 61
33025348 2020
21
Extracellular Vesicles in HTLV-1 Communication: The Story of an Invisible Messenger. 61
33322043 2020
22
CD30-positive lymphomatous (nonleukemic) variant of adult T-cell leukemia/lymphoma, HTLV-1 associated. 61
33363748 2020
23
Clinicopathological analysis of immunohistochemical expression of CD47 and SIRPα in adult T-cell leukemia/lymphoma. 61
32569413 2020
24
Cutaneous plaque in adult T cell leukemia/lymphoma: A case report. 61
33327284 2020
25
A Methodology for Assessing Tumor Clonality of Adult T Cell Leukemia/Lymphoma. 61
33313334 2020
26
Adult T-cell leukemia/lymphoma clinically confused with viral/drug skin eruptions and pathologically misinterpreted as mycosis fungoides/Sézary syndrome. 61
33354782 2020
27
TACC3 expression as a prognostic factor in aggressive types of adult T-cell leukemia/lymphoma patients. 61
32744749 2020
28
Case Report: An Uncommon Clinical Case of Fatal Adult T-Cell Leukemia/Lymphoma Associated with HTLV-1 and Suspected due to Cutaneous Lesions and Epidemiologic Data. 61
32783798 2020
29
Adult T-cell Leukemia-lymphoma with Primary Breast Involvement: A Case Report and Literature Review. 61
32641657 2020
30
Phylogenetic and phylodynamic study of Human T-cell lymphotropic virus Type 1 (HTLV-1) in Iran. 61
32561293 2020
31
The Antihelminthic Drug, Mebendazole, Induces Apoptosis in Adult T-Cell Leukemia/Lymphoma Cancer Cells: In-Vitro Trial. 61
33603987 2020
32
Development of anti-human CADM1 monoclonal antibodies as a potential therapy for adult T-cell leukemia/lymphoma. 61
32656636 2020
33
Endoscopic and clinicopathological characteristics of colorectal T/NK cell lymphoma. 61
33087157 2020
34
Provirus Mutations of Human T-Lymphotropic Virus 1 and 2 (HTLV-1 and HTLV-2) in HIV-1-Coinfected Individuals. 61
32999083 2020
35
Mogamulizumab Plus EPOCH Therapy for Patients With Newly Diagnosed Aggressive Adult T-cell Leukemia/lymphoma. 61
32878812 2020
36
Clinical characteristics of adult T-cell leukemia/lymphoma infiltration in the gastrointestinal tract. 61
32928148 2020
37
HLA-B*35 as a new marker for susceptibility to human T-cell lymphotropic virus type 1 (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina. 61
32883310 2020
38
Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma. 61
32859220 2020
39
Clinical and cytopathological characteristics of HTLV-1+ hodgkin lymphoma. 61
32597011 2020
40
Improved survival for skin-primary presentation of adult T-cell leukemia/lymphoma (ATLL). 61
31765683 2020
41
Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia/Lymphoma-Romanian Experience. 61
32731502 2020
42
Molecular targeting of PD-1 signaling pathway as a novel therapeutic approach in HTLV-1 infection. 61
32283259 2020
43
Human T cell lymphotropic virus type-1 associated lymphoma presenting as an intramuscular mass of the calf. 61
32076761 2020
44
cDNA-Based Mutation Screening Using a Combination of High-Resolution Melting Curve and Fragment Analysis Facilitates Efficient CCR4 Mutation Analysis in Adult T-Cell Leukemia/Lymphoma. 61
32367127 2020
45
Mechanisms of Oncogenesis by HTLV-1 Tax. 61
32645846 2020
46
Dermatopathic reaction of lymph nodes in HTLV-1 carriers: a spectrum of reactive and neoplastic lesions. 61
32162348 2020
47
The broad and challenging landscape of extranodal lymphoproliferations. 61
31758317 2020
48
Synthetic (E)-3-Phenyl-5-(phenylamino)-2-styryl-1,3,4-thiadiazol-3-ium Chloride Derivatives as Promising Chemotherapy Agents on Cell Lines Infected with HTLV-1. 61
32486038 2020
49
The Frequency and Risk Factors of Human T-cell Lymphotropic Virus Type I among Blood Donors in Khorasan-e Razavi, Iran, from 2002 to 2013. 61
33100467 2020
50
Mortality and risk of progression to adult T cell leukemia/lymphoma in HTLV-1-associated myelopathy/tropical spastic paraparesis. 61
32393644 2020

Variations for T-Cell Adult Acute Lymphocytic Leukemia

Expression for T-Cell Adult Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for T-Cell Adult Acute Lymphocytic Leukemia.

Pathways for T-Cell Adult Acute Lymphocytic Leukemia

Pathways related to T-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 TNFRSF8 JAK3 IL2 CREB1 CD4 CD2
2
Show member pathways
13.5 TNFRSF8 JAK3 IL2 CREB1 CD4 CD2
3
Show member pathways
13.23 TNFRSF8 JAK3 IL2 CREB1 CD4 CD2
4
Show member pathways
12.71 IL2 FOXP3 CREB1 CD8A CD4
5
Show member pathways
12.43 JAK3 IRF4 IL2 FOXP3 CD4
6
Show member pathways
12.39 IRF4 IL2 CREB1 CD8A CD4 ALK
7 12.18 JAK3 IL2 CREB1 CD4
8 12.01 TNFRSF8 JAK3 IRF4 IL2 FOXP3 CD8A
9 11.95 CNTN2 CD8A CD4 CD2
10
Show member pathways
11.72 JAK3 IRF4 FOXP3
11 11.72 IL2 CD8A CD5 CD4 CD2
12
Show member pathways
11.6 IRF4 IL2 FOXP3
13 11.57 IRF4 IL2 CD8A CD4
14 11.55 CD8A CD7 CD5 CD4 CD2
15
Show member pathways
11.53 JAK3 IL2 FOXP3
16 11.29 JAK3 IL2 FOXP3 CD4
17 11.21 JAK3 CD8A CD4
18 11 IRF4 IL2 CD8A CD7 CD4 CCR6

GO Terms for T-Cell Adult Acute Lymphocytic Leukemia

Cellular components related to T-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 CD8A CD5 CD4 CD2 CCR6 CCR4
2 external side of plasma membrane GO:0009897 9.1 CD8A CD5 CD4 CD2 CCR6 CCR4

Biological processes related to T-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.93 JAK3 IRF4 IL2 CD8A CD7 CD4
2 adaptive immune response GO:0002250 9.88 JAK3 IL2 CD8A CD7 CD4
3 positive regulation of kinase activity GO:0033674 9.67 IL2 CD4 ALK
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.56 CD8A CD7 CD4 ALK
5 positive regulation of regulatory T cell differentiation GO:0045591 9.55 IL2 FOXP3
6 interleukin-15-mediated signaling pathway GO:0035723 9.54 JAK3 CD4
7 positive regulation of T cell proliferation GO:0042102 9.54 JAK3 IL2 CD4
8 interleukin-2-mediated signaling pathway GO:0038110 9.52 JAK3 IL2
9 T cell mediated immunity GO:0002456 9.51 FOXP3 CD8A
10 negative regulation of T-helper 17 cell differentiation GO:2000320 9.43 IL2 FOXP3
11 immune response GO:0006955 9.43 IL2 CD8A CD7 CD4 CCR6 CCR4
12 enzyme linked receptor protein signaling pathway GO:0007167 9.4 JAK3 CD4
13 negative regulation of lymphocyte proliferation GO:0050672 9.32 IL2 FOXP3
14 tolerance induction GO:0002507 9.16 FOXP3 CCR4
15 T cell activation GO:0042110 9.1 IRF4 FOXP3 CD8A CD7 CD4 CD2

Molecular functions related to T-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 TNFRSF8 TIA1 PTHLH JAK3 IRF4 IL2
2 signaling receptor activity GO:0038023 9.02 CD7 CD5 CD4 CD2 CCR6

Sources for T-Cell Adult Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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