MCID: TCL018
MIFTS: 20

T-Cell Childhood Acute Lymphocytic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for T-Cell Childhood Acute Lymphocytic Leukemia

MalaCards integrated aliases for T-Cell Childhood Acute Lymphocytic Leukemia:

Name: T-Cell Childhood Acute Lymphocytic Leukemia 12
T-Cell Childhood Acute Lymphoblastic Leukemia 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0080145
NCIt 50 C7953
UMLS 73 C0279583

Summaries for T-Cell Childhood Acute Lymphocytic Leukemia

Disease Ontology : 12 A childhood acute lymphoblastic leukemia that has_material_basis in T-cells.

MalaCards based summary : T-Cell Childhood Acute Lymphocytic Leukemia, also known as t-cell childhood acute lymphoblastic leukemia, is related to precursor t-cell acute lymphoblastic leukemia. An important gene associated with T-Cell Childhood Acute Lymphocytic Leukemia is TAL1 (TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor). The drugs Cyclophosphamide and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include t cells and bone.

Related Diseases for T-Cell Childhood Acute Lymphocytic Leukemia

Diseases related to T-Cell Childhood Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 precursor t-cell acute lymphoblastic leukemia 9.7 TAL1 IL7

Symptoms & Phenotypes for T-Cell Childhood Acute Lymphocytic Leukemia

Drugs & Therapeutics for T-Cell Childhood Acute Lymphocytic Leukemia

Drugs for T-Cell Childhood Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 142)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
3
leucovorin Approved Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
4
Daunorubicin Approved Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
5
Methotrexate Approved Phase 3,Phase 2,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
7
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 68538-85-2
8
Cytarabine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4 6253
9
Thioguanine Approved Phase 3,Not Applicable 154-42-7 2723601
10
Prednisone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 53-03-2 5865
11
Ifosfamide Approved Phase 3,Phase 1 3778-73-2 3690
12
Vindesine Approved, Investigational Phase 3 59917-39-4, 53643-48-4 40839
13
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 57-22-7, 2068-78-2 5978
14
Doxorubicin Approved, Investigational Phase 3,Phase 2,Not Applicable 23214-92-8 31703
15
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
16
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492
17
Sirolimus Approved, Investigational Phase 3,Phase 1 53123-88-9 46835353 6436030 5284616
18
Thiotepa Approved, Investigational Phase 3,Phase 2,Phase 1 52-24-4 5453
19
Everolimus Approved Phase 3,Phase 1 159351-69-6 6442177
20
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
21
Hydrocortisone acetate Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-03-3
22
Prednisolone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-24-8 5755
23
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2,Not Applicable 302-25-0
24
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 83-43-2 6741
25
Mitoxantrone Approved, Investigational Phase 3,Phase 1,Not Applicable 65271-80-9 4212
26
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2,Not Applicable 2921-57-5
27
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-23-7 5754
28
Pegaspargase Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
29
Idarubicin Approved Phase 3 58957-92-9 42890
30
Cortisone acetate Approved, Investigational Phase 3 1950-04-4, 50-04-4 5745
31
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
32
Bortezomib Approved, Investigational Phase 3,Phase 2 179324-69-7 387447 93860
33
Mechlorethamine Approved, Investigational Phase 3,Phase 1 51-75-2 4033
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
35
Doxil Approved June 1999 Phase 3,Phase 2,Not Applicable 31703
36
Prednisolone hemisuccinate Experimental Phase 3,Phase 2,Not Applicable 2920-86-7
37
Cortisone Experimental Phase 3 53-06-5 222786
38 Antiviral Agents Phase 3,Phase 2,Phase 1,Not Applicable
39 Hormones Phase 3,Phase 2,Phase 1,Not Applicable
40 BB 1101 Phase 3,Phase 2,Phase 1,Not Applicable
41 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1,Not Applicable
43 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
44 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
45
Isophosphamide mustard Phase 3,Phase 1 0
46 Folic Acid Antagonists Phase 3,Phase 2,Phase 1,Not Applicable
47 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1,Not Applicable
48 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable
49 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1,Not Applicable
50 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
2 Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission Unknown status NCT00382109 Phase 3 thiotepa;cyclophosphamide;tacrolimus;methotrexate;sirolimus
3 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
4 Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed NCT00967057 Phase 3 asparaginase;dexamethasone;idarubicin;methotrexate;mitoxantrone hydrochloride;pegaspargase;vincristine sulfate
5 Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00557193 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Lestaurtinib;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Therapeutic Hydrocortisone;Vincristine Sulfate
6 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00430118 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
7 Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma Completed NCT01230983 Phase 3 asparaginase;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
8 Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Active, not recruiting NCT00707083 Phase 3 dexamethasone;mercaptopurine;methotrexate;vincristine sulfate
9 Treatment of Acute Lymphoblastic Leukemia in Children Active, not recruiting NCT00400946 Phase 3 asparaginase;cyclophosphamide;cytarabine;dexamethasone;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;therapeutic hydrocortisone;vincristine sulfate
10 Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Suspended NCT02112916 Phase 3 Bortezomib;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Thioguanine;Vincristine Sulfate
11 506U78 in Treating Patients With Refractory Hematologic Cancer Completed NCT00002970 Phase 2 nelarabine;methotrexate;cytarabine;therapeutic hydrocortisone
12 Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia Completed NCT00002704 Phase 2 asparaginase;cyclophosphamide;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;liposomal cytarabine;mercaptopurine;mesna;methotrexate;therapeutic hydrocortisone;thiotepa;vincristine sulfate
13 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
14 Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Completed NCT00873093 Phase 2 L-asparaginase;doxorubicin hydrochloride;therapeutic hydrocortisone;vincristine sulfate;cytarabine;prednisone;bortezomib;pegaspargase;methotrexate;etoposide phosphate;cyclophosphamide;leucovorin calcium;High Dose MTX
15 Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia Completed NCT00061945 Phase 1, Phase 2 allopurinol;cyclophosphamide;daunorubicin hydrochloride;vincristine sulfate;dexamethasone;asparaginase;imatinib mesylate;methotrexate;cytarabine;trimethoprim-sulfamethoxazole;mercaptopurine;leucovorin calcium;acyclovir
16 Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation Completed NCT00052520 Phase 1, Phase 2
17 506U78 in Treating Patients With Refractory or Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Completed NCT00003545 Phase 2 nelarabine
18 Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma Completed NCT01403415 Phase 1 Dexamethasone;Methotrexate;Mitoxantrone Hydrochloride;Pegaspargase;Temsirolimus;Vincristine Sulfate
19 Cellular Adoptive Immunotherapy in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndromes That Relapsed After Donor Stem Cell Transplant Completed NCT00107354 Phase 1 cytarabine;etoposide;mitoxantrone hydrochloride
20 Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer Completed NCT00005092 Phase 1 Cyclophosphamide;Psoralen;Thiotepa
21 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
22 Oxaliplatin, Ifosfamide and Etoposide in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma Terminated NCT00101205 Phase 1 oxaliplatin;etoposide
23 Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia Unknown status NCT00550992 Not Applicable asparaginase;busulfan;cyclophosphamide;cyclosporine;cytarabine;daunorubicin hydrochloride;etoposide;leucovorin calcium;melphalan;mercaptopurine;methotrexate;mitoxantrone hydrochloride;pegaspargase;prednisolone;prednisone;therapeutic hydrocortisone;thioguanine;vincristine sulfate
24 Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00343369 Not Applicable asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;teniposide;thioguanine;vincristine sulfate
25 Study of Long-Term Outcomes of Patients With Acute Lymphoblastic Leukemia Who Were Enrolled as Children on Clinical Trials EORTC-58741, EORTC-58831, EORTC-58832, or EORTC-58881 Between 1971 and 1998 Unknown status NCT01298388
26 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00016302 Not Applicable prednisone;vincristine sulfate;daunorubicin hydrochloride;asparaginase;methotrexate;cyclophosphamide;cytarabine;mercaptopurine;leucovorin calcium;dexamethasone;doxorubicin hydrochloride;thioguanine;nelarabine;pegaspargase
27 Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic Leukemia Completed NCT01626183
28 Response or Resistance to Chemotherapy in Young Patients With Acute Lymphoblastic Leukemia Treated With Methotrexate Completed NCT00898404
29 Studying Samples From Patients With T-Cell Acute Lymphoblastic Leukemia Completed NCT01581528
30 Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes Completed NCT00096135 Not Applicable cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;therapeutic hydrocortisone;vincristine sulfate
31 Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00049569 Not Applicable cytarabine;methotrexate;vincristine sulfate;prednisone;pegaspargase;doxorubicin hydrochloride;imatinib mesylate;cyclophosphamide;etoposide;leucovorin calcium;asparaginase;therapeutic hydrocortisone
32 Metabolic Syndrome in Young Patients With Acute Lymphoblastic Leukemia in Remission Completed NCT00801346
33 Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia Completed NCT00437060
34 Biomarker Study in Bone Marrow Samples From Patients With T-Cell Acute Lymphoblastic Leukemia Completed NCT01295476
35 DNA Analysis of Tissue From Patients With T-Cell Acute Lymphoblastic Leukemia Completed NCT00899366
36 Study of Blood and Tissue Samples in Children With Newly Diagnosed Acute Lymphoblastic Leukemia Active, not recruiting NCT01185886

Search NIH Clinical Center for T-Cell Childhood Acute Lymphocytic Leukemia

Genetic Tests for T-Cell Childhood Acute Lymphocytic Leukemia

Anatomical Context for T-Cell Childhood Acute Lymphocytic Leukemia

MalaCards organs/tissues related to T-Cell Childhood Acute Lymphocytic Leukemia:

41
T Cells, Bone

Publications for T-Cell Childhood Acute Lymphocytic Leukemia

Articles related to T-Cell Childhood Acute Lymphocytic Leukemia:

# Title Authors Year
1
An unusual T-cell childhood acute lymphoblastic leukemia harboring a yet unreported near-tetraploid karyotype. ( 21936943 )
2011
2
M-BCR rearrangement in a case of T-cell childhood acute lymphoblastic leukemia. ( 10358709 )
1999
3
Isochromosome 14q in T cell childhood acute lymphoblastic leukemia. ( 8956882 )
1996

Variations for T-Cell Childhood Acute Lymphocytic Leukemia

Expression for T-Cell Childhood Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for T-Cell Childhood Acute Lymphocytic Leukemia.

Pathways for T-Cell Childhood Acute Lymphocytic Leukemia

GO Terms for T-Cell Childhood Acute Lymphocytic Leukemia

Sources for T-Cell Childhood Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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