MCID: TCL018
MIFTS: 19

T-Cell Childhood Acute Lymphocytic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for T-Cell Childhood Acute Lymphocytic Leukemia

MalaCards integrated aliases for T-Cell Childhood Acute Lymphocytic Leukemia:

Name: T-Cell Childhood Acute Lymphocytic Leukemia 12
T-Cell Childhood Acute Lymphoblastic Leukemia 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0080145
NCIt 49 C7953
UMLS 71 C0279583

Summaries for T-Cell Childhood Acute Lymphocytic Leukemia

Disease Ontology : 12 A childhood acute lymphoblastic leukemia that has material basis in T-cells.

MalaCards based summary : T-Cell Childhood Acute Lymphocytic Leukemia, also known as t-cell childhood acute lymphoblastic leukemia, is related to precursor t-cell acute lymphoblastic leukemia and acute t cell leukemia. An important gene associated with T-Cell Childhood Acute Lymphocytic Leukemia is TAL1 (TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor). The drugs Mitoxantrone and Daunorubicin have been mentioned in the context of this disorder. Affiliated tissues include t cells and myeloid.

Related Diseases for T-Cell Childhood Acute Lymphocytic Leukemia

Diseases related to T-Cell Childhood Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 precursor t-cell acute lymphoblastic leukemia 9.6 TAL1 IL7
2 acute t cell leukemia 9.5 TAL1 IL7
3 lymphoma, non-hodgkin, familial 9.5 TAL1 IL7
4 leukemia, acute lymphoblastic 9.4 TAL1 IL7
5 leukemia, acute myeloid 9.2 TAL1 IL7

Graphical network of the top 20 diseases related to T-Cell Childhood Acute Lymphocytic Leukemia:



Diseases related to T-Cell Childhood Acute Lymphocytic Leukemia

Symptoms & Phenotypes for T-Cell Childhood Acute Lymphocytic Leukemia

Drugs & Therapeutics for T-Cell Childhood Acute Lymphocytic Leukemia

Drugs for T-Cell Childhood Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
2
Daunorubicin Approved Phase 3 20830-81-3 30323
3
Thioguanine Approved Phase 3 154-42-7 2723601
4
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
5
Etoposide Approved Phase 3 33419-42-0 36462
6
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
7
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
8
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
9
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
10
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
11
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
12
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
13
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
14
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
15 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
16
Pegaspargase Approved, Investigational Phase 3 130167-69-0
17
Ifosfamide Approved Phase 3 3778-73-2 3690
18
Vindesine Approved, Investigational Phase 3 53643-48-4, 59917-39-4 40839
19
Idarubicin Approved Phase 3 58957-92-9 42890
20
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
21
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
22
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
23
leucovorin Approved Phase 3 58-05-9 6006 143
24
Mercaptopurine Approved Phase 3 50-44-2 667490
25
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
26
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
27
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
28
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
29 Analgesics Phase 3
30 Anti-Infective Agents Phase 3
31 Topoisomerase Inhibitors Phase 3
32 Antiviral Agents Phase 3
33 Etoposide phosphate Phase 3
34 Hydrocortisone hemisuccinate Phase 3
35 Alkylating Agents Phase 3
36 Hydrocortisone-17-butyrate Phase 3
37 Anti-Bacterial Agents Phase 3
38 Hydrocortisone 17-butyrate 21-propionate Phase 3
39
asparaginase Phase 3
40 Antibiotics, Antitubercular Phase 3
41 Calcium, Dietary Phase 3
42 Methylprednisolone Acetate Phase 3
43
Liposomal doxorubicin Phase 3 31703
44 razoxane Phase 3
45 Protective Agents Phase 3
46 Antidotes Phase 3
47
Isophosphamide mustard Phase 3 0
48 Neuroprotective Agents Phase 3
49 Immunosuppressive Agents Phase 3
50 Immunologic Factors Phase 3

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial of the I-BFM-SG for the Management of Childhood Non-B Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
2 The Value of Dexamethasone Versus Prednisolone During Induction and Maintenance Therapy of Prolonged Versus Conventional Duration of L-Asparaginase Therapy During Consolidation and Late Intensification, and of Corticosteroid + VCR Pulses During Maintenance in Acute Lymphoblastic Leukemia and Lymphoblastic Non-Hodgkin Lymphoma of Childhood Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
3 Intensive Treatment For T-CELL Acute Lymphoblastic Leukemia and Advanced Stage Lymphoblastic Non-Hodgkin's Lymphoma: A Pediatric Oncology Group Phase III Study Completed NCT01230983 Phase 3 asparaginase;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
4 ALL-BFM 2000 Multi-Center Study for the Treatment of Children and Adolescents With Acute Lymphoblastic Leukemia Completed NCT00430118 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
5 ALLR3: An International Collaborative Trial for Relapsed and Refractory Acute Lymphoblastic Leukaemia (ALL) Completed NCT00967057 Phase 3 asparaginase;dexamethasone;idarubicin;methotrexate;mitoxantrone hydrochloride;pegaspargase;vincristine sulfate
6 Treatment of Acute Lymphoblastic Leukemia in Children Completed NCT00400946 Phase 3 asparaginase;cyclophosphamide;cytarabine;dexamethasone;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;therapeutic hydrocortisone;vincristine sulfate
7 A Multicenter Study of Treatment Protocol for Childhood Acute Lymphoblastic Leukemia in China, 2008. Active, not recruiting NCT00707083 Phase 3 dexamethasone;mercaptopurine;methotrexate;vincristine sulfate
8 A Phase II Study of 506U78 in Patients With Refractory or Relapsed T-Lineage Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphomas (LBL) Completed NCT00003545 Phase 2 nelarabine
9 TREATMENT OF ISOLATED CNS RELAPSE OF ACUTE LYMPHOBLASTIC LEUKEMIA -- A PEDIATRIC ONCOLOGY GROUP-WIDE PHASE II STUDY Completed NCT00002704 Phase 2 asparaginase;cyclophosphamide;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;liposomal cytarabine;mercaptopurine;mesna;methotrexate;therapeutic hydrocortisone;thiotepa;vincristine sulfate
10 Phase I Study of Adoptive Immunotherapy With CD8 Minor Histocompatibility (H) Antigen-Specific CTL Clones for Patients With Relapsed of AML or ALL After Allogeneic Hematopoietic Stem Cell Transplant Completed NCT00107354 Phase 1 cytarabine;etoposide;mitoxantrone hydrochloride
11 A Phase I Study of Photochemically Treated Donor T-Cell Supplements in HLA Haplotype Mismatched Hematopoietic Stem Cell Transplantation Completed NCT00005092 Phase 1 Cyclophosphamide;Psoralen;Thiotepa
12 Assessment of the Long Term Outcome of Childhood ALL Patients Enrolled in EORTC Children's Leukemia Group Trials Between 1971 and 1998 Unknown status NCT01298388
13 Multicentric Study for the Treatment of Children With Acute Lymphoblastic Leukemia Unknown status NCT00343369 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;teniposide;thioguanine;vincristine sulfate
14 Molecular Taxonomy in Pediatric Cancer- IncRNA Expression in Primary T-ALL Completed NCT01626183
15 Molecular Mechanisms of NOTCH Induced Transformation in T-ALL Completed NCT00899366
16 Biological Correlates With T-cell Acute Lymphoblastic Leukemia (T-ALL) Gene Expression and Clinical Outcome Completed NCT01295476
17 The Metabolic Syndrome in Pediatric Acute Lymphoblastic Leukemia (ALL). Completed NCT00801346
18 Metabolic Pathways in T-Cell Acute Lymphoblastic Leukemia (T-ALL) Completed NCT01581528
19 Treatment of Late Isolated Extramedullary Relapse From Acute Lymphoblastic Leukemia (ALL) (Initial CR1≥ 18 Months) Completed NCT00096135 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;therapeutic hydrocortisone;vincristine sulfate
20 The Use of Modified BFM +/- Compound 506U78 (Nelarabine) (NSC# 686673, IND #52611) in an Intensive Chemotherapy Regimen for the Treatment of T-Cell Leukemia Completed NCT00016302 prednisone;vincristine sulfate;daunorubicin hydrochloride;asparaginase;methotrexate;cyclophosphamide;cytarabine;mercaptopurine;leucovorin calcium;dexamethasone;doxorubicin hydrochloride;thioguanine;nelarabine;pegaspargase
21 International Collaborative Treatment Protocol for Infants Under One Year With Acute Lymphoblastic or Biphenotypic Leukemia Recruiting NCT00550992 asparaginase;busulfan;cyclophosphamide;cyclosporine;cytarabine;daunorubicin hydrochloride;etoposide;leucovorin calcium;melphalan;mercaptopurine;methotrexate;mitoxantrone hydrochloride;pegaspargase;prednisolone;prednisone;therapeutic hydrocortisone;thioguanine;vincristine sulfate
22 Translational Research - Observational Study for Identification of New Possible Prognostic Factors and Future Therapeutic Targets in Children With Acute Lymphoblastic Leukemia (ALL) Active, not recruiting NCT01185886

Search NIH Clinical Center for T-Cell Childhood Acute Lymphocytic Leukemia

Genetic Tests for T-Cell Childhood Acute Lymphocytic Leukemia

Anatomical Context for T-Cell Childhood Acute Lymphocytic Leukemia

MalaCards organs/tissues related to T-Cell Childhood Acute Lymphocytic Leukemia:

40
T Cells, Myeloid

Publications for T-Cell Childhood Acute Lymphocytic Leukemia

Articles related to T-Cell Childhood Acute Lymphocytic Leukemia:

(show all 11)
# Title Authors PMID Year
1
An unusual T-cell childhood acute lymphoblastic leukemia harboring a yet unreported near-tetraploid karyotype. 61
21936943 2011
2
In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptotic cell death in context of maturation stage, responsiveness to interleukin 7, and early cytoreduction in vivo in childhood T-cell acute lymphoblastic leukemia. 54
12010814 2002
3
TEL/JAK2 tyrosine kinase inhibits DNA repair in the presence of amifostine. 61
12136932 2002
4
Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia. 54
10891465 2000
5
M-BCR rearrangement in a case of T-cell childhood acute lymphoblastic leukemia. 61
10358709 1999
6
Detection of minimal residual disease by PCR in childhood T-cell acute lymphoblastic leukemia with TAL1 gene rearrangement: a preliminary report. 54
9950206 1999
7
[TAL1 gene analysis in T-cell malignancies]. 54
9597892 1998
8
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. 61
9360930 1997
9
Isochromosome 14q in T cell childhood acute lymphoblastic leukemia. 61
8956882 1996
10
Clinical significance of TAL1 gene alteration in childhood T-cell acute lymphoblastic leukemia and lymphoma. 54
8321044 1993
11
Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study. 54
8471769 1993

Variations for T-Cell Childhood Acute Lymphocytic Leukemia

Expression for T-Cell Childhood Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for T-Cell Childhood Acute Lymphocytic Leukemia.

Pathways for T-Cell Childhood Acute Lymphocytic Leukemia

GO Terms for T-Cell Childhood Acute Lymphocytic Leukemia

Sources for T-Cell Childhood Acute Lymphocytic Leukemia

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61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
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72 UMLS via Orphanet
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