MCID: TCL003
MIFTS: 43

T Cell Deficiency

Categories: Immune diseases

Aliases & Classifications for T Cell Deficiency

MalaCards integrated aliases for T Cell Deficiency:

Name: T Cell Deficiency 12 15
T-Lymphocyte Deficiency 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11200
NCIt 51 C27872

Summaries for T Cell Deficiency

Disease Ontology : 12 A primary immunodeficiency disease that is characterized by decreased functioning of the T cells, which are drivers of cell-mediated immunity, resulting in increased susceptibility to intracellular bacterial, viral, and fungal infections, and has material basis in a primary immunodeficiency or secondary to chronic infection, illness, or drugs.

MalaCards based summary : T Cell Deficiency, also known as t-lymphocyte deficiency, is related to immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia and immune defect due to absence of thymus. An important gene associated with T Cell Deficiency is CD247 (CD247 Molecule), and among its related pathways/superpathways are Akt Signaling and Allograft rejection. The drugs Fludarabine and alemtuzumab have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are cellular and hematopoietic system

Wikipedia : 77 T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it... more...

Related Diseases for T Cell Deficiency

Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia 31.6 LRBA MAGT1
2 immune defect due to absence of thymus 30.7 FOXN1 IL2 SMARCAL1 ZAP70
3 combined t cell and b cell immunodeficiency 29.6 IL2 IL7R ZAP70
4 severe combined immunodeficiency 29.2 IL2 IL7R PTPRC ZAP70
5 digeorge syndrome 11.3
6 t-cell receptor-alpha/beta deficiency 11.3
7 immunodeficiency due to defect in mapbp-interacting protein 11.0
8 severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive 10.2 IL7R PTPRC
9 cd45 deficiency 10.0 PTPRC ZAP70
10 combined immunodeficiency, x-linked 10.0 CARMIL2 ZAP70
11 severe combined immunodeficiency, x-linked 10.0 IL2 IL7R
12 hepatitis 9.9
13 common variable immunodeficiency 9.9
14 lymphopenia 9.8 IL2 IL7R MAGT1
15 autoimmune lymphoproliferative syndrome 9.8 IL2 LRBA PTPRC
16 multiple sclerosis 9.8
17 systemic lupus erythematosus 9.8
18 anemia, autoimmune hemolytic 9.8
19 graft-versus-host disease 9.8
20 adult t-cell leukemia 9.8
21 arthritis 9.8
22 hematopoietic stem cell transplantation 9.8
23 hemolytic anemia 9.8
24 leukemia 9.8
25 glucose intolerance 9.8
26 pneumocystosis 9.8
27 dermatitis 9.8
28 pneumonia 9.8
29 t-cell leukemia 9.8
30 lupus erythematosus 9.8
31 toxoplasmosis 9.8
32 hyper ige syndrome 9.8
33 b-cell expansion with nfkb and t-cell anergy 9.7 IL2 ZAP70
34 autoimmune disease 9.6
35 hepatocellular carcinoma 9.6
36 cryoglobulinemia, familial mixed 9.6
37 schizophrenia 9.6
38 ataxia-telangiectasia 9.6
39 charge syndrome 9.6
40 myeloma, multiple 9.6
41 sjogren syndrome 9.6
42 fabry disease 9.6
43 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.6
44 dermatitis, atopic 9.6
45 pulmonary disease, chronic obstructive 9.6
46 granulomatosis with polyangiitis 9.6
47 cholangitis, primary sclerosing 9.6
48 alopecia 9.6
49 brain injury 9.6
50 cataract 9.6

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to T Cell Deficiency

Symptoms & Phenotypes for T Cell Deficiency

MGI Mouse Phenotypes related to T Cell Deficiency:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 CD247 FOXN1 IL2 IL7R LAMTOR2 PTPRC
2 hematopoietic system MP:0005397 9.9 CARMIL2 CD247 FOXN1 IL2 IL7R LRBA
3 endocrine/exocrine gland MP:0005379 9.86 CARMIL2 CD247 FOXN1 IL2 IL7R PTPRC
4 immune system MP:0005387 9.7 CARMIL2 CD247 FOXN1 IL2 IL7R LRBA
5 normal MP:0002873 9.1 CD247 FOXN1 IL7R MAGT1 PTPRC ZAP70

Drugs & Therapeutics for T Cell Deficiency

Drugs for T Cell Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 1, Phase 2,Phase 2 75607-67-9, 21679-14-1 30751
2
alemtuzumab Approved, Investigational Phase 1, Phase 2 216503-57-0
3 Immunoglobulins Phase 1, Phase 2
4 Antibodies, Monoclonal Phase 1, Phase 2
5 Antimetabolites Phase 1, Phase 2
6 Antineoplastic Agents, Immunological Phase 1, Phase 2
7 Immunosuppressive Agents Phase 1, Phase 2
8 Antibodies Phase 1, Phase 2
9 Antimetabolites, Antineoplastic Phase 1, Phase 2
10 Immunologic Factors Phase 1, Phase 2
11 Acidophilus Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Allogeneic SCT Of Pts With SCID And Other Primary Immunodeficiency Disorders Terminated NCT00579137 Phase 1, Phase 2 Fludarabine
2 Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases Active, not recruiting NCT02231710 Phase 1
3 Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency Completed NCT00011141 Not Applicable Oral lactobacillus administration
4 Evaluation of HIV-Negative Patients With Low CD4+ T Lymphocyte Counts Completed NCT00001319

Search NIH Clinical Center for T Cell Deficiency

Genetic Tests for T Cell Deficiency

Anatomical Context for T Cell Deficiency

MalaCards organs/tissues related to T Cell Deficiency:

42
T Cells, B Cells, Bone, Bone Marrow, Thymus, Skin, Neutrophil

Publications for T Cell Deficiency

Articles related to T Cell Deficiency:

(show top 50) (show all 122)
# Title Authors Year
1
21st Century FOX: Toward Gene Therapy for the Regulatory T Cell Deficiency Syndrome IPEX. ( 30735648 )
2019
2
Baboon envelope LVs efficiently transduced human adult, fetal, and progenitor T cells and corrected SCID-X1 T-cell deficiency. ( 30755435 )
2019
3
Regulatory T-cell deficiency leads to pathogenic bullous pemphigoid antigen 230 autoantibody and autoimmune bullous disease. ( 29704595 )
2018
4
Correction of T cell deficiency in ZAP-70 knockout mice by simple intraperitoneal adoptive transfer of thymocytes. ( 29431868 )
2018
5
Regulatory T-cell deficiency and autoimmune skin disease: Beyond the scurfy mouse and immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. ( 30196121 )
2018
6
Tregopathies: Monogenic diseases resulting in regulatory T-cell deficiency. ( 30527062 )
2018
7
Tap water: A possible source of nontuberculous mycobacterial infection in patients with T cell deficiency. ( 30527279 )
2018
8
Expansion of cytotoxic CD56(bright) natural killer cells during T-cell deficiency after allogeneic hematopoietic stem cell transplantation. ( 28778795 )
2017
9
Roles of Aluminum Hydroxide and Monophosphoryl Lipid A Adjuvants in Overcoming CD4+ T Cell Deficiency To Induce Isotype-Switched IgG Antibody Responses and Protection by T-Dependent Influenza Vaccine. ( 27881702 )
2017
10
Both mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition. ( 28385777 )
2017
11
Peripheral invariant natural killer T cell deficiency in metabolically unhealthy but normal weight versus metabolically healthy but obese individuals. ( 28322093 )
2016
12
Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on I^I'T cells in mice. ( 25791517 )
2015
13
T cell deficiency in spinal cord injury: altered locomotor recovery and whole-genome transcriptional analysis. ( 26546062 )
2015
14
Hypomorphic interleukin-7 receptor I+-chain mutations and T-cell deficiency: a delay in diagnosis. ( 26123418 )
2015
15
Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA. ( 25468195 )
2015
16
Syndrome of selective IgM deficiency with severe T cell deficiency associated with disseminated cutaneous mycobacterium avium intracellulaire infection. ( 26550546 )
2015
17
Mucosal-Associated Invariant T Cell Deficiency in Chronic Obstructive Pulmonary Disease. ( 26552490 )
2015
18
Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity. ( 26414901 )
2015
19
Blood dendritic cell levels associated with impaired IL-12 production and T-cell deficiency in patients with kidney disease: implications for post-transplant viral infections. ( 24963818 )
2014
20
Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. ( 25225673 )
2014
21
Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency. ( 24530773 )
2014
22
Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency on antiretroviral therapy are associated with T-cell activation and senescence. ( 24499954 )
2014
23
Clinical features of cytotoxic CD8+ T-lymphocyte deficiency in chronic rhinosinusitis patients: a demographic and functional study. ( 24639246 )
2014
24
T-Lymphocyte Deficiency Exacerbates Behavioral Deficits in the 6-OHDA Unilateral Lesion Rat Model for Parkinson's Disease. ( 25346865 )
2014
25
Regulatory T-cell deficiency in rheumatic heart disease: a preliminary observational study. ( 23610999 )
2013
26
VI'2 T cell deficiency in granulomatosis with polyangiitis (Wegener's granulomatosis). ( 23891739 )
2013
27
Fine-tuning of regulatory T cell function: the role of calcium signals and naive regulatory T cells for regulatory T cell deficiency in multiple sclerosis. ( 23576680 )
2013
28
Impaired spatial memory in mice lacking CD3IP is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency. ( 24259588 )
2013
29
The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats. ( 23228347 )
2013
30
Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation. ( 23478176 )
2013
31
Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model. ( 22425450 )
2012
32
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. ( 22312480 )
2012
33
CD8 T cell deficiency impairs control of Epstein--Barr virus and worsens with age in multiple sclerosis. ( 21791511 )
2012
34
Natural killer T cell deficiency in active adult-onset Still's Disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. ( 22605480 )
2012
35
CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. ( 22006994 )
2011
36
T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. ( 21492943 )
2011
37
IL-15 ex vivo overcomes CD4+ T cell deficiency for the induction of human antigen-specific CD8+ T cell responses. ( 21474552 )
2011
38
Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation. ( 20505149 )
2010
39
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. ( 20548030 )
2010
40
Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine. ( 20463106 )
2010
41
Profound invariant natural killer T-cell deficiency in inflammatory arthritis. ( 20444757 )
2010
42
Newborn screening for T-cell deficiency. ( 20864885 )
2010
43
Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. ( 20103644 )
2010
44
Hematopoietic stem cell transplantation for profound T-cell deficiency (combined immunodeficiency). ( 20493397 )
2010
45
Can T-cell deficiency affect spatial learning ability following toluene exposure? ( 19923859 )
2010
46
Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency. ( 19664144 )
2009
47
Congenital T cell deficiency in a patient with CHARGE syndrome. ( 19187738 )
2009
48
Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. ( 19230472 )
2009
49
The effects of T cell deficiency on the development of worms and granuloma formation in mice infected with Schistosoma japonicum. ( 18246371 )
2008
50
Hepatitis and human bocavirus primary infection in a child with T-cell deficiency. ( 18842946 )
2008

Variations for T Cell Deficiency

Expression for T Cell Deficiency

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for T Cell Deficiency

Pathways related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 CD247 IL2 IL7R RHOH ZAP70
2
Show member pathways
12.63 CD247 IL2 PTPRC ZAP70
3
Show member pathways
12.32 CD247 IL2 PTPRC ZAP70
4
Show member pathways
12.11 CD247 PTPRC ZAP70
5
Show member pathways
11.87 CD247 IL2 PTPRC ZAP70
6
Show member pathways
11.85 CD247 IL2 ZAP70
7
Show member pathways
11.69 CD247 RHOH ZAP70
8 11.67 IL2 IL7R PTPRC
9 11.65 CD247 RHOH ZAP70
10
Show member pathways
11.64 CD247 IL2 PTPRC ZAP70
11
Show member pathways
11.62 CD247 PTPRC ZAP70
12 11.6 IL2 IL7R PTPRC
13
Show member pathways
11.58 CD247 PTPRC ZAP70
14 11.4 IL2 IL7R PTPRC
15 11.31 CD247 PTPRC ZAP70
16 11.3 CD247 ZAP70
17 11.3 IL2 IL7R PTPRC
18 11.09 IL2 ZAP70
19 11.06 IL2 ZAP70
20 10.99 CD247 IL2
21 10.93 CD247 IL2
22 10.37 IL7R PTPRC ZAP70

GO Terms for T Cell Deficiency

Cellular components related to T Cell Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.61 CARMIL2 CD247 IL7R LAMTOR2 LRBA MAGT1
2 immunological synapse GO:0001772 9.16 RHOH ZAP70
3 T cell receptor complex GO:0042101 8.62 CD247 ZAP70

Biological processes related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.7 CD247 IL7R PTPRC
2 T cell receptor signaling pathway GO:0050852 9.61 CD247 PTPRC ZAP70
3 T cell activation GO:0042110 9.51 PTPRC ZAP70
4 positive regulation of B cell proliferation GO:0030890 9.49 IL2 PTPRC
5 establishment or maintenance of cell polarity GO:0007163 9.48 CARMIL2 RHOH
6 B cell proliferation GO:0042100 9.46 IL7R PTPRC
7 negative thymic T cell selection GO:0045060 9.4 PTPRC ZAP70
8 positive thymic T cell selection GO:0045059 9.37 PTPRC ZAP70
9 positive regulation of alpha-beta T cell proliferation GO:0046641 9.32 PTPRC ZAP70
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.26 IL2 PTPRC
11 negative regulation of T cell mediated cytotoxicity GO:0001915 9.16 IL7R PTPRC
12 positive regulation of T cell differentiation GO:0045582 9.13 IL2 PTPRC ZAP70
13 T cell differentiation GO:0030217 9.02 IL2 IL7R PTPRC RHOH ZAP70

Sources for T Cell Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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