MCID: TCL003
MIFTS: 45

T Cell Deficiency

Categories: Immune diseases

Aliases & Classifications for T Cell Deficiency

MalaCards integrated aliases for T Cell Deficiency:

Name: T Cell Deficiency 12 15
T Lymphocyte Immunodeficiency 12
T-Lymphocyte Deficiency 71
T Cell Immunodeficiency 12
T Lymphocyte Deficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11200
UMLS 71 C1274233 C1333147 C1744558

Summaries for T Cell Deficiency

Disease Ontology : 12 A primary immunodeficiency disease that is characterized by decreased numbers of circulating or functioning T cells.

MalaCards based summary : T Cell Deficiency, also known as t lymphocyte immunodeficiency, is related to immune defect due to absence of thymus and immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia. An important gene associated with T Cell Deficiency is PTPRC (Protein Tyrosine Phosphatase Receptor Type C), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Vidarabine and Adenosine have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are cellular and hematopoietic system

Wikipedia : 74 T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it... more...

Related Diseases for T Cell Deficiency

Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 505)
# Related Disease Score Top Affiliating Genes
1 immune defect due to absence of thymus 32.3 FOXN1 CD40LG
2 immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia 31.8 MAGT1 DOCK8 CD8A CD27
3 digeorge syndrome 31.0 RAG1 IL7 FOXN1 DOCK8 CD8A CD40LG
4 thymic dysplasia 30.6 FOXN1 CD4
5 immuno-osseous dysplasia 30.3 SMARCAL1 IL7R
6 esophageal candidiasis 30.2 CD8A CD4 CCR6
7 severe combined immunodeficiency, x-linked 30.2 IL7R IL7 IL2 IL15
8 adult t-cell leukemia 30.0 IL2 IL15 CD4 CCR6
9 visceral leishmaniasis 30.0 IL2 IL15 CD28
10 cryptococcosis 30.0 CD8A CD4 CCR6
11 poliomyelitis 30.0 CD8A CD40LG CD4
12 chronic mucocutaneous candidiasis 29.9 DOCK8 CD8A CD4 CCR6
13 cholangitis, primary sclerosing 29.9 CD8A CD40LG CD4 CCR6
14 lymphoproliferative syndrome 29.9 PTPRC LRBA IL2 CD27
15 lymphocytic leukemia 29.9 PTPRC IL2 CD40LG CCR6
16 t-cell adult acute lymphocytic leukemia 29.8 IL2 CD8A CD4 CCR6
17 vitiligo-associated multiple autoimmune disease susceptibility 1 29.8 IL2 CD8A CD4 CCR6
18 thrombocytopenia due to platelet alloimmunization 29.7 CD8A CD40LG CD4 CCR6
19 pneumocystosis 29.7 CD8A CD40LG CD4 CCR6
20 neuromyelitis optica 29.7 IL7R CD40LG CD27
21 bacterial infectious disease 29.7 IL15 CD8A CD40LG CD4 CCR6
22 listeriosis 29.7 PTPRC IL7R IL2 CD8A CD4 CCR6
23 acquired immunodeficiency syndrome 29.7 IL2 IL15 CD40LG CD4 CCR6
24 autoimmune disease 29.7 IL7R IL2 IL15 CD40LG CD28 CCR6
25 orchitis 29.7 IL2 CD8A CD40LG CD4
26 herpes zoster 29.6 IL2 CD8A CD40LG CD4
27 systemic scleroderma 29.6 CD8A CD40LG CD4 CCR6
28 mycobacterium tuberculosis 1 29.6 PTPRC IL7 CD8A CD4 CCR6
29 epidermodysplasia verruciformis 1 29.6 IL7 DOCK8 CD8A CD4 CCR6
30 tetanus 29.5 IL7R IL2 CD40LG CD27 CD247
31 anemia, autoimmune hemolytic 29.5 IL2 DOCK8 CD8A CD40LG CD4
32 leukemia, acute lymphoblastic 29.5 RAG1 PTPRC IL7R IL7 CD247 CCR6
33 leprosy 3 29.4 IL2 CD8A CD40LG CD4 CCR6
34 skin disease 29.4 IL7 IL2 CD8A CD40LG CD4 CCR6
35 granulomatosis with polyangiitis 29.3 IL7R CD40LG CD4 CD28 CCR6
36 connective tissue disease 29.3 IL2 CD8A CD40LG CD4 CCR6
37 lymphopenia 29.3 RAG1 MAGT1 IL7R IL7 IL2 IL15
38 stomatitis 29.2 IL2 CD40LG CD4
39 progressive multifocal leukoencephalopathy 29.2 RAG1 IL2 CD8A CD40LG CD4 CCR6
40 inflammatory bowel disease 29.1 PTPRC LRBA IL2 IL15 CD8A CD40LG
41 aplastic anemia 29.1 IL2 IL15 CD4 CD28 CD27
42 severe combined immunodeficiency 29.0 RAG1 PTPRC IL7R IL7 IL2 IL15
43 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 29.0 LRBA IL7R IL2 DOCK8 CD8A CD4
44 common variable immunodeficiency 28.7 RAG1 LRBA IL7 IL2 IL15 CD40LG
45 chickenpox 28.7 IL2 DOCK8 CD8A CD40LG CD4 CD27
46 diabetes mellitus, insulin-dependent 28.6 PTPRC IL2 IL15 CD8A CD40LG CD4
47 dermatitis, atopic 28.5 PTPRC IL7 IL2 CD8A CD40LG CD4
48 combined t cell and b cell immunodeficiency 28.3 RAG1 PTPRC IL7R IL7 IL2 IL15
49 sarcoidosis 1 28.2 PTPRC IL2 IL15 CD8A CD40LG CD4
50 b cell deficiency 28.2 RAG1 LRBA IL2 DOCK8 CD8A CD40LG

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to T Cell Deficiency

Symptoms & Phenotypes for T Cell Deficiency

MGI Mouse Phenotypes related to T Cell Deficiency:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 CD247 CD27 CD28 CD4 CD40LG CD8A
2 hematopoietic system MP:0005397 10.13 CCR6 CD247 CD27 CD28 CD4 CD40LG
3 endocrine/exocrine gland MP:0005379 10.03 CD247 CD28 CD4 CD40LG CD8A FOXN1
4 immune system MP:0005387 9.93 CCR6 CD247 CD27 CD28 CD4 CD40LG
5 normal MP:0002873 9.32 CCR6 CD247 CD28 CD4 CD8A FOXN1

Drugs & Therapeutics for T Cell Deficiency

Drugs for T Cell Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vidarabine Approved, Investigational Phase 1, Phase 2 24356-66-9 32326 21704
2
Adenosine Approved, Investigational Phase 2 58-61-7 60961
3
rituximab Approved Phase 2 174722-31-7 10201696
4
Busulfan Approved, Investigational Phase 2 55-98-1 2478
5
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
6
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
7
Pentostatin Approved, Investigational Phase 2 53910-25-1 40926 439693
8
Mycophenolic acid Approved Phase 2 24280-93-1 446541
9
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
10
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
11
alemtuzumab Approved, Investigational Phase 1, Phase 2 216503-57-0
12 Alkylating Agents Phase 2
13 Anti-Infective Agents Phase 1, Phase 2
14 Antiviral Agents Phase 1, Phase 2
15 Antirheumatic Agents Phase 2
16 Immunologic Factors Phase 2
17 Antimetabolites Phase 1, Phase 2
18 Immunosuppressive Agents Phase 1, Phase 2
19 Antineoplastic Agents, Immunological Phase 1, Phase 2
20 Antibodies, Monoclonal Phase 1, Phase 2
21 Immunoglobulins Phase 1, Phase 2
22 Antibodies Phase 1, Phase 2
23
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
24
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
25 Antilymphocyte Serum Phase 1
26 Thymoglobulin Phase 1
27 Cyclosporins Phase 1
28 Anesthetics Phase 1
29 Hormones Phase 1
30 Calcium, Dietary Phase 1
31 Acidophilus

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Phase I/II Trial of De-Escalation of Busulfan With Fludarabine and Antithymocyte Globulin as Preparative Therapy for Hematopoietic Stem Cell Transplant for the Treatment of Severe Congenital T-Cell Immunodeficiency Completed NCT00228852 Phase 1, Phase 2 Busulfan, Fludarabine and ATG
2 Phase II Trial of Pentostatin, Cyclophosphamide and Rituximab (PCR) Followed by Campath-1H for Previously Treated Relapsed or Refractory Patients With Chronic Lymphocytic Leukemia Completed NCT00074282 Phase 2 cyclophosphamide;pentostatin;Alemtuzumab
3 Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies Recruiting NCT02579967 Phase 2 Immunosuppression Only Conditioning - Closed with amendment L;Reduced Intensity Conditioning;Myeloablative Conditioning-Closed with amendment L;GVHD Prophylaxis
4 Sargramostim to Reverse Myeloid Dendritic Cell Deficiency Terminated NCT03063242 Phase 2 Sargramostim
5 CD45 and Alemtuzumab Monoclonal Antibody Conditioning Regimen For Allogeneic Donor Stem Cell Transplantation Of Patients With Severe Combined Immunodeficiency Disease (SCID) And Other Primary Immunodeficiency Disorders Terminated NCT00579137 Phase 1, Phase 2 Fludarabine
6 A Study Evaluating BPX-501 T Cells and AP1903 for Prevention of Graft Versus Host Disease (GVHD) After Haploidentical, Related, T Cell-Depleted Hematopoietic Cell Transplantation for Non-Malignant Diseases Active, not recruiting NCT02231710 Phase 1
7 Thymus Transplantation With Immunosuppression, #884 Active, not recruiting NCT00579709 Phase 1
8 Parathyroid and Thymus Transplantation in DiGeorge Syndrome, #931 Active, not recruiting NCT00566488 Phase 1
9 Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency Completed NCT00011141 Oral lactobacillus administration
10 Developing Newborn Screening for Infants With Primary Immunodeficiency Completed NCT00113464
11 Sequential Transplantation of Umbilical Cord Blood Stem Cells and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency Type 1 Diabetes Mellitus Recruiting NCT03835312
12 Retrospective Study of the Breadth of Donor Options for Patients With Inherited Diseases Requiring Allogeneic Hematopoietic Stem Cell Transplant in the Era of Alternative Donor Transplants Using Post-Transplantation Cyclophosphamide Enrolling by invitation NCT03188419

Search NIH Clinical Center for T Cell Deficiency

Genetic Tests for T Cell Deficiency

Anatomical Context for T Cell Deficiency

MalaCards organs/tissues related to T Cell Deficiency:

40
T Cells, B Cells, Bone, Thymus, Bone Marrow, Skin, Lung

Publications for T Cell Deficiency

Articles related to T Cell Deficiency:

(show top 50) (show all 599)
# Title Authors PMID Year
1
Abnormal Newborn Screening Follow-up for Severe Combined Immunodeficiency in an Amish Cohort with Cartilage-Hair Hypoplasia. 61
31903518 2020
2
CD8 T cells and STAT1 signaling are essential co-determinants in protection from polyomavirus encephalopathy. 61
31996425 2020
3
In case of recurrent wheezing and bronchiolitis: Think again, it may be a primary immunodeficiency. 61
31837214 2019
4
T Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization, and Extracellular Matrix Remodeling. 61
31637099 2019
5
The Il9 CNS-25 Regulatory Element Controls Mast Cell and Basophil IL-9 Production. 61
31350354 2019
6
Prevalence of Epstein-Barr virus infection and characteristics of lymphocyte subsets in newly onset juvenile dermatomyositis. 61
31549298 2019
7
The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis. 61
31204070 2019
8
A case of Good's syndrome complicated by erythema multiforme. 61
31434669 2019
9
The accumulation of T cells within acellular nerve allografts is length-dependent and critical for nerve regeneration. 61
31085199 2019
10
CD4+ T Cell Regulation of Antibodies Cross-Reactive with Fungal Cell Wall-Associated Carbohydrates after Pneumocystis murina Infection. 61
31010812 2019
11
Tap water: A possible source of nontuberculous mycobacterial infection in patients with T cell deficiency. 61
30527279 2019
12
Clinical and immunological features in a cohort of patients with partial DiGeorge syndrome followed at a single center. 61
31015189 2019
13
Factors Beyond Lack of Antibody Govern Pulmonary Complications in Primary Antibody Deficiency. 61
31089938 2019
14
Immunodeficiency, Motor Delay, and Hypouricemia Caused by a Novel Mutation of Purine Nucleoside Phosphorylase Gene in an Indian Infant. 61
31007444 2019
15
Activation of T Lymphocytes as a Novel Mechanism in Beta1-Adrenergic Receptor Autoantibody-Induced Cardiac Remodeling. 61
30747396 2019
16
Small Numbers of CD4+ T Cells Can Induce Development of Lymphedema. 61
30601329 2019
17
Decrease in αβ/γδ T-cell ratio is accompanied by a reduction in high-fat diet-induced weight gain, insulin resistance, and inflammation. 61
30285581 2019
18
Baboon envelope LVs efficiently transduced human adult, fetal, and progenitor T cells and corrected SCID-X1 T-cell deficiency. 61
30755435 2019
19
21st Century FOX: Toward Gene Therapy for the Regulatory T Cell Deficiency Syndrome IPEX. 61
30735648 2019
20
Mycobacteria-Specific T Cells May Be Expanded From Healthy Donors and Are Near Absent in Primary Immunodeficiency Disorders. 61
30984189 2019
21
T-Cell-Driven Inflammation as a Mediator of the Gut-Brain Axis Involved in Parkinson's Disease. 61
30828335 2019
22
Antibody Responses in HIV-Infected Patients With Advanced Immunosuppression and Asymptomatic Cryptococcal Antigenemia. 61
30648127 2019
23
Ataxia Telangiectasia Diagnosed on Newborn Screening-Case Cohort of 5 Years' Experience. 61
31921190 2019
24
T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation. 61
30241692 2019
25
Fetal Hydrops Secondary to in utero Pancytopenia. 61
29972823 2019
26
Regulatory T-cell deficiency and autoimmune skin disease: Beyond the scurfy mouse and immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. 61
30196121 2018
27
Regulatory T-cell deficiency leads to pathogenic bullous pemphigoid antigen 230 autoantibody and autoimmune bullous disease. 61
29704595 2018
28
Tregopathies: Monogenic diseases resulting in regulatory T-cell deficiency. 61
30527062 2018
29
The contribution of immune activation and accelerated aging in multiple myeloma occurring in HIV-infected population. 61
30234600 2018
30
Newborn Screening for Severe Combined Immunodeficiency: Analytic and Clinical Performance of the T Cell Receptor Excision Circle Assay in France (DEPISTREC Study). 61
30251145 2018
31
CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS). 61
30036637 2018
32
CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection. 61
30372487 2018
33
Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner. 61
30373628 2018
34
Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity. 61
30170813 2018
35
Anti-mouse CD52 Treatment Ameliorates Colitis through Suppressing Th1/17 Mediated Inflammation and Promoting Tregs Differentiation in IL-10 Deficient Mice. 61
29899181 2018
36
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells. 61
30262807 2018
37
Control of Cytomegalovirus Viremia after Allogeneic Stem Cell Transplantation: A Review on CMV-Specific T Cell Reconstitution. 61
29626514 2018
38
Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta. 61
29448016 2018
39
Correction of T cell deficiency in ZAP-70 knock-out mice by simple intraperitoneal adoptive transfer of thymocytes. 61
29431868 2018
40
Dynamic changes in the immunological characteristics of T lymphocytes in surviving patients with severe fever with thrombocytopenia syndrome (SFTS). 61
29550447 2018
41
Inherited Immunodeficiency: A New Association With Early-Onset Childhood Panniculitis. 61
29610179 2018
42
CD8+ T cells in beige adipogenesis and energy homeostasis. 61
29515042 2018
43
γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice. 61
29262837 2017
44
A novel compound heterozygous mutation of the SMARCAL1 gene leading to mild Schimke immune-osseous dysplasia: a case report. 61
29282041 2017
45
The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model. 61
29212195 2017
46
Cellular therapy for multiple pathogen infections after hematopoietic stem cell transplant. 61
28927824 2017
47
Expansion of cytotoxic CD56bright natural killer cells during T-cell deficiency after allogeneic hematopoietic stem cell transplantation. 61
28778795 2017
48
T cell-mediated antitumor immune response eliminates skin tumors induced by mouse papillomavirus, MmuPV1. 61
28939161 2017
49
[Construction of injectable tissue engineered adipose tissue with fibrin glue scaffold and human adipose-derived stem cells transfected by lentivirus vector expressing hepatocyte growth factor]. 61
29798571 2017
50
T-cell prolymphocytic leukemia and tuberculosis: a puzzling association. 61
28878921 2017

Variations for T Cell Deficiency

Expression for T Cell Deficiency

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for T Cell Deficiency

Pathways related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 RAG1 PTPRC MAGT1 LAMTOR2 IL7R IL7
2
Show member pathways
13.8 IL7R IL7 IL2 IL15 CD40LG CD4
3
Show member pathways
13.65 SMARCAL1 IL7R IL7 IL2 IL15 CD40LG
4
Show member pathways
13.37 IL7R IL7 IL2 IL15 CD40LG CD4
5
Show member pathways
13.34 RAG1 LAMTOR2 IL7R IL7 IL2 IL15
6
Show member pathways
13.17 PTPRC IL7R IL7 IL2 IL15 CD40LG
7
Show member pathways
12.82 IL2 IL15 CD8A CD40LG CD4 CD28
8
Show member pathways
12.63 PTPRC IL2 CD40LG CD4 CD28 CD247
9 12.55 RAG1 PTPRC IL2 CD8A CD40LG CD28
10
Show member pathways
12.52 PTPRC IL2 CD8A CD40LG CD4 CD28
11
Show member pathways
12.37 PTPRC IL2 CD40LG CD4 CD28 CD247
12
Show member pathways
12.31 IL7R IL7 IL2 IL15
13 12.11 PTPRC CD8A CD40LG CD4 CD28
14
Show member pathways
11.97 IL2 CD8A CD4 CD247
15
Show member pathways
11.93 PTPRC CD8A CD4 CD28 CD247
16 11.9 IL7R IL7 CD8A CD4
17 11.88 PTPRC IL7R IL2 IL15
18
Show member pathways
11.78 CD4 CD28 CD247
19 11.74 CD8A CD4 CD28 CD247
20 11.71 PTPRC CD4 CD247
21 11.62 PTPRC IL7R IL7 IL2 IL15 CD8A
22
Show member pathways
11.61 IL2 CD8A CD247
23 11.59 CD40LG CD28 CD27
24 11.59 PTPRC IL7R IL2 CD8A CD4
25 11.48 IL2 CD4 CD28
26 11.38 PTPRC IL7R CD40LG CD4 CD27
27 11.32 IL2 CD40LG CD28
28 11.28 IL2 CD8A CD28
29 11.24 IL7 IL2 IL15 CD4
30 11.23 RAG1 IL7R IL7
31 11.21 RAG1 PTPRC IL7R CD8A CD40LG CD4
32 11.2 IL2 CD4 CD28 CD247
33 11.13 PTPRC IL7R IL7 IL2 IL15 CD8A

GO Terms for T Cell Deficiency

Cellular components related to T Cell Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 PTPRC MAGT1 LRBA LAMTOR2 IL7R DOCK8
2 integral component of plasma membrane GO:0005887 9.76 PTPRC MAGT1 CD8A CD40LG CD4 CD28
3 cell surface GO:0009986 9.5 PTPRC IL15 CD40LG CD4 CD28 CD27
4 external side of plasma membrane GO:0009897 9.23 PTPRC IL7R CD8A CD40LG CD4 CD28

Biological processes related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.02 IL7 IL2 CD40LG CD28 CD27
2 cell surface receptor signaling pathway GO:0007166 9.87 PTPRC IL7R CD8A CD4 CD28 CD27
3 T cell receptor signaling pathway GO:0050852 9.84 PTPRC CD4 CD28 CD247
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 PTPRC IL15 CD4
5 B cell differentiation GO:0030183 9.77 RAG1 PTPRC CD40LG
6 humoral immune response GO:0006959 9.75 IL7 CD28 CCR6
7 T cell activation GO:0042110 9.71 PTPRC CD8A CD4 CD28
8 positive regulation of B cell proliferation GO:0030890 9.7 PTPRC IL7 IL2
9 B cell proliferation GO:0042100 9.69 PTPRC IL7R CD40LG
10 regulation of defense response to virus by virus GO:0050690 9.67 CD4 CD28 CD247
11 T cell differentiation GO:0030217 9.67 PTPRC IL7R IL2 CD4
12 positive regulation of interleukin-17 production GO:0032740 9.63 IL2 IL15
13 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.63 PTPRC CD4 CD28
14 positive regulation of T cell proliferation GO:0042102 9.63 PTPRC IL2 IL15 CD40LG CD4 CD28
15 positive regulation of B cell differentiation GO:0045579 9.61 IL7 CD27
16 interleukin-15-mediated signaling pathway GO:0035723 9.61 IL15 CD4
17 positive regulation of isotype switching to IgG isotypes GO:0048304 9.61 PTPRC IL2 CD28
18 negative thymic T cell selection GO:0045060 9.6 PTPRC CD28
19 positive regulation of alpha-beta T cell proliferation GO:0046641 9.58 PTPRC CD28
20 positive regulation of tissue remodeling GO:0034105 9.57 IL2 IL15
21 T cell lineage commitment GO:0002360 9.56 IL7 FOXN1
22 negative regulation of T cell apoptotic process GO:0070233 9.56 RAG1 IL7R DOCK8 CD27
23 negative regulation of T cell mediated cytotoxicity GO:0001915 9.55 PTPRC IL7R
24 DN2 thymocyte differentiation GO:1904155 9.48 PTPRC CCR6
25 positive regulation of T cell differentiation GO:0045582 9.35 RAG1 PTPRC IL7 IL2 CD27
26 immune response GO:0006955 9.32 RAG1 IL7R IL7 IL2 IL15 CD8A

Molecular functions related to T Cell Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 SMARCAL1 RAG1 PTPRC LRBA LAMTOR2 IL7R
2 cytokine activity GO:0005125 9.46 IL7 IL2 IL15 CD40LG
3 coreceptor activity GO:0015026 8.8 CD8A CD4 CD28

Sources for T Cell Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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