MCID: TCL003
MIFTS: 44

T Cell Deficiency

Categories: Immune diseases

Aliases & Classifications for T Cell Deficiency

MalaCards integrated aliases for T Cell Deficiency:

Name: T Cell Deficiency 12 15
T-Lymphocyte Deficiency 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11200
NCIt 50 C27872

Summaries for T Cell Deficiency

MalaCards based summary : T Cell Deficiency, also known as t-lymphocyte deficiency, is related to immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia and combined t cell and b cell immunodeficiency. An important gene associated with T Cell Deficiency is CD247 (CD247 Molecule), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Fludarabine and alemtuzumab have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and thymus, and related phenotypes are cellular and hematopoietic system

Wikipedia : 76 T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it... more...

Related Diseases for T Cell Deficiency

Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia 31.5 LRBA MAGT1
2 combined t cell and b cell immunodeficiency 29.6 CD3G IL2 IL7R ZAP70
3 severe combined immunodeficiency 29.2 IL2 IL7R PNP PTPRC ZAP70
4 digeorge syndrome 11.3
5 t-cell receptor-alpha/beta deficiency 11.2
6 schimke immunoosseous dysplasia 10.9
7 immunodeficiency due to defect in mapbp-interacting protein 10.9
8 severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive 10.2 IL7R PTPRC
9 immunodeficiency 18 10.1 CD3G PTPRC
10 extracutaneous mastocytoma 10.1 CD2 PTPRC
11 cd45 deficiency 10.1 PTPRC ZAP70
12 immunodeficiency 19 10.1 CD3G ZAP70
13 immunodeficiency 17 10.1 CD3G PTPRC
14 reticulum cell sarcoma 10.1 CD2 PTPRC
15 severe combined immunodeficiency, x-linked 10.0 IL2 IL7R
16 thymic dysplasia 10.0 CD2 FOXN1
17 autoimmune lymphoproliferative syndrome 10.0 IL2 LRBA PTPRC
18 t-cell adult acute lymphocytic leukemia 10.0 CD2 IL2
19 mast cell neoplasm 10.0 CD2 IL2
20 specific bursitis often of occupational origin 10.0 CD2 PNP
21 olecranon bursitis 10.0 CD2 PNP
22 lymphatic system cancer 9.9 CD2 PTPRC
23 leukocyte disease 9.9 CD2 IL2 PTPRC
24 thymoma 9.9 CD2 IL2 PTPRC
25 follicular mucinosis 9.9 CD2 PTPRC
26 common variable immunodeficiency 9.9
27 hepatitis 9.9
28 lymphopenia 9.8 CD3G IL2 IL7R MAGT1
29 multiple sclerosis 9.8
30 systemic lupus erythematosus 9.8
31 anemia, autoimmune hemolytic 9.8
32 adult t-cell leukemia 9.8
33 arthritis 9.8
34 hematopoietic stem cell transplantation 9.8
35 hemolytic anemia 9.8
36 glucose intolerance 9.8
37 pneumocystosis 9.8
38 pneumonia 9.8
39 t-cell leukemia 9.8
40 lupus erythematosus 9.8
41 hyper ige syndrome 9.8
42 hepatocellular carcinoma 9.6
43 cryoglobulinemia, familial mixed 9.6
44 schizophrenia 9.6
45 ataxia-telangiectasia 9.6
46 charge syndrome 9.6
47 myeloma, multiple 9.6
48 fabry disease 9.6
49 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.6
50 pulmonary disease, chronic obstructive 9.6

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to T Cell Deficiency

Symptoms & Phenotypes for T Cell Deficiency

MGI Mouse Phenotypes related to T Cell Deficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 CD247 CD3G FOXN1 IL2 IL7R LAMTOR2
2 hematopoietic system MP:0005397 9.9 CD247 CD3G FOXN1 IL2 IL7R LRBA
3 endocrine/exocrine gland MP:0005379 9.86 CD247 CD3G FOXN1 IL2 IL7R PTPRC
4 immune system MP:0005387 9.7 CD247 CD3G FOXN1 IL2 IL7R LRBA
5 normal MP:0002873 9.17 CD2 CD247 FOXN1 IL7R MAGT1 PTPRC

Drugs & Therapeutics for T Cell Deficiency

Drugs for T Cell Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 1, Phase 2,Phase 2 75607-67-9, 21679-14-1 30751
2
alemtuzumab Approved, Investigational Phase 1, Phase 2 216503-57-0
3 Immunologic Factors Phase 1, Phase 2
4 Antimetabolites, Antineoplastic Phase 1, Phase 2
5 Immunoglobulins Phase 1, Phase 2
6 Antibodies Phase 1, Phase 2
7 Antimetabolites Phase 1, Phase 2
8 Immunosuppressive Agents Phase 1, Phase 2
9 Antibodies, Monoclonal Phase 1, Phase 2
10 Acidophilus Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Allogeneic SCT Of Pts With SCID And Other Primary Immunodeficiency Disorders Terminated NCT00579137 Phase 1, Phase 2 Fludarabine
2 Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases Terminated NCT02231710 Phase 1
3 Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency Completed NCT00011141 Not Applicable Oral lactobacillus administration
4 Evaluation of HIV-Negative Patients With Low CD4+ T Lymphocyte Counts Completed NCT00001319

Search NIH Clinical Center for T Cell Deficiency

Genetic Tests for T Cell Deficiency

Anatomical Context for T Cell Deficiency

MalaCards organs/tissues related to T Cell Deficiency:

41
T Cells, B Cells, Thymus, Skin, Brain, Heart, Spinal Cord

Publications for T Cell Deficiency

Articles related to T Cell Deficiency:

(show top 50) (show all 121)
# Title Authors Year
1
Regulatory T-cell deficiency leads to pathogenic bullous pemphigoid antigen 230 autoantibody and autoimmune bullous disease. ( 29704595 )
2018
2
Correction of T cell deficiency in ZAP-70 knockout mice by simple intraperitoneal adoptive transfer of thymocytes. ( 29431868 )
2018
3
Regulatory T-cell deficiency and autoimmune skin disease: Beyond the scurfy mouse and immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. ( 30196121 )
2018
4
Tregopathies: Monogenic diseases resulting in regulatory T-cell deficiency. ( 30527062 )
2018
5
Tap water: A possible source of nontuberculous mycobacterial infection in patients with T cell deficiency. ( 30527279 )
2018
6
Expansion of cytotoxic CD56(bright) natural killer cells during T-cell deficiency after allogeneic hematopoietic stem cell transplantation. ( 28778795 )
2017
7
Roles of Aluminum Hydroxide and Monophosphoryl Lipid A Adjuvants in Overcoming CD4+ T Cell Deficiency To Induce Isotype-Switched IgG Antibody Responses and Protection by T-Dependent Influenza Vaccine. ( 27881702 )
2017
8
Both mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition. ( 28385777 )
2017
9
Peripheral invariant natural killer T cell deficiency in metabolically unhealthy but normal weight versus metabolically healthy but obese individuals. ( 28322093 )
2016
10
Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on I^I'T cells in mice. ( 25791517 )
2015
11
T cell deficiency in spinal cord injury: altered locomotor recovery and whole-genome transcriptional analysis. ( 26546062 )
2015
12
Hypomorphic interleukin-7 receptor I+-chain mutations and T-cell deficiency: a delay in diagnosis. ( 26123418 )
2015
13
Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA. ( 25468195 )
2015
14
Syndrome of selective IgM deficiency with severe T cell deficiency associated with disseminated cutaneous mycobacterium avium intracellulaire infection. ( 26550546 )
2015
15
Mucosal-Associated Invariant T Cell Deficiency in Chronic Obstructive Pulmonary Disease. ( 26552490 )
2015
16
Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity. ( 26414901 )
2015
17
Blood dendritic cell levels associated with impaired IL-12 production and T-cell deficiency in patients with kidney disease: implications for post-transplant viral infections. ( 24963818 )
2014
18
Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. ( 25225673 )
2014
19
Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency. ( 24530773 )
2014
20
Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency on antiretroviral therapy are associated with T-cell activation and senescence. ( 24499954 )
2014
21
Clinical features of cytotoxic CD8+ T-lymphocyte deficiency in chronic rhinosinusitis patients: a demographic and functional study. ( 24639246 )
2014
22
T-Lymphocyte Deficiency Exacerbates Behavioral Deficits in the 6-OHDA Unilateral Lesion Rat Model for Parkinson's Disease. ( 25346865 )
2014
23
Regulatory T-cell deficiency in rheumatic heart disease: a preliminary observational study. ( 23610999 )
2013
24
VI'2 T cell deficiency in granulomatosis with polyangiitis (Wegener's granulomatosis). ( 23891739 )
2013
25
Fine-tuning of regulatory T cell function: the role of calcium signals and naive regulatory T cells for regulatory T cell deficiency in multiple sclerosis. ( 23576680 )
2013
26
Impaired spatial memory in mice lacking CD3IP is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency. ( 24259588 )
2013
27
The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats. ( 23228347 )
2013
28
Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation. ( 23478176 )
2013
29
Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model. ( 22425450 )
2012
30
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. ( 22312480 )
2012
31
CD8 T cell deficiency impairs control of Epstein--Barr virus and worsens with age in multiple sclerosis. ( 21791511 )
2012
32
Natural killer T cell deficiency in active adult-onset Still's Disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. ( 22605480 )
2012
33
CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. ( 22006994 )
2011
34
T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. ( 21492943 )
2011
35
IL-15 ex vivo overcomes CD4+ T cell deficiency for the induction of human antigen-specific CD8+ T cell responses. ( 21474552 )
2011
36
Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation. ( 20505149 )
2010
37
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. ( 20548030 )
2010
38
Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine. ( 20463106 )
2010
39
Profound invariant natural killer T-cell deficiency in inflammatory arthritis. ( 20444757 )
2010
40
Newborn screening for T-cell deficiency. ( 20864885 )
2010
41
Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. ( 20103644 )
2010
42
Hematopoietic stem cell transplantation for profound T-cell deficiency (combined immunodeficiency). ( 20493397 )
2010
43
Can T-cell deficiency affect spatial learning ability following toluene exposure? ( 19923859 )
2010
44
Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency. ( 19664144 )
2009
45
Congenital T cell deficiency in a patient with CHARGE syndrome. ( 19187738 )
2009
46
Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. ( 19230472 )
2009
47
The effects of T cell deficiency on the development of worms and granuloma formation in mice infected with Schistosoma japonicum. ( 18246371 )
2008
48
Hepatitis and human bocavirus primary infection in a child with T-cell deficiency. ( 18842946 )
2008
49
Generating functional CD8+ T cell memory response under transient CD4+ T cell deficiency: implications for vaccination of immunocompromised individuals. ( 18506880 )
2008
50
Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15. ( 18465774 )
2008

Variations for T Cell Deficiency

Expression for T Cell Deficiency

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for T Cell Deficiency

Pathways related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CD247 CD3G IL2 IL7R LAMTOR2 MAGT1
2
Show member pathways
13.23 CD2 CD247 CD3G IL2 IL7R RHOH
3
Show member pathways
12.93 CD247 CD3G IL2 RHOH ZAP70
4
Show member pathways
12.74 CD247 CD3G IL2 PTPRC ZAP70
5
Show member pathways
12.46 CD247 CD3G IL2 ZAP70
6 12.43 CD2 IL2 PTPRC ZAP70
7
Show member pathways
12.41 CD247 CD3G IL2 PTPRC ZAP70
8
Show member pathways
12.21 CD247 CD3G PTPRC ZAP70
9
Show member pathways
12.18 CD3G PTPRC ZAP70
10
Show member pathways
11.93 CD247 CD3G IL2 ZAP70
11
Show member pathways
11.86 CD247 CD3G IL2
12 11.83 CD247 CD3G ZAP70
13 11.77 CD2 CD3G IL7R
14
Show member pathways
11.77 CD247 CD3G RHOH ZAP70
15
Show member pathways
11.76 CD247 CD3G IL2 PTPRC ZAP70
16 11.75 IL2 IL7R PTPRC
17 11.72 CD247 CD3G RHOH ZAP70
18 11.69 CD2 IL2 IL7R PTPRC
19 11.68 IL2 IL7R PTPRC
20 11.65 CD247 CD3G PTPRC
21 11.63 IL2 IL7R PTPRC
22 11.62 CD247 CD3G ZAP70
23
Show member pathways
11.6 CD247 CD3G PTPRC ZAP70
24 11.59 CD247 CD3G ZAP70
25 11.51 CD247 CD3G ZAP70
26
Show member pathways
11.51 CD247 CD3G IL2
27
Show member pathways
11.49 CD247 CD3G PTPRC ZAP70
28 11.4 CD247 CD3G ZAP70
29 11.4 CD247 CD3G PTPRC ZAP70
30
Show member pathways
11.4 CD247 CD3G IL2 PTPRC ZAP70
31 11.21 CD247 CD3G
32 11.18 IL2 ZAP70
33 11.15 IL2 ZAP70
34 11.15 IL7R PTPRC ZAP70
35 11.07 CD247 IL2
36 10.99 CD247 CD3G IL2

GO Terms for T Cell Deficiency

Cellular components related to T Cell Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.96 CD2 CD247 CD3G IL7R LAMTOR2 LRBA
2 external side of plasma membrane GO:0009897 9.46 CD2 CD3G IL7R PTPRC
3 immunological synapse GO:0001772 9.32 RHOH ZAP70
4 alpha-beta T cell receptor complex GO:0042105 8.96 CD247 CD3G
5 T cell receptor complex GO:0042101 8.8 CD247 CD3G ZAP70

Biological processes related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.87 IL2 IL7R PNP ZAP70
2 neutrophil degranulation GO:0043312 9.86 LAMTOR2 MAGT1 PNP PTPRC
3 adaptive immune response GO:0002250 9.81 CD247 CD3G IL2 ZAP70
4 cell surface receptor signaling pathway GO:0007166 9.72 CD2 CD247 CD3G IL7R PTPRC
5 T cell receptor signaling pathway GO:0050852 9.67 CD247 CD3G PTPRC ZAP70
6 positive regulation of T cell proliferation GO:0042102 9.61 IL2 PNP PTPRC
7 establishment or maintenance of cell polarity GO:0007163 9.58 CD3G RHOH
8 B cell proliferation GO:0042100 9.58 IL7R PTPRC
9 natural killer cell activation GO:0030101 9.55 CD2 IL2
10 heterotypic cell-cell adhesion GO:0034113 9.54 CD2 PTPRC
11 negative thymic T cell selection GO:0045060 9.52 PTPRC ZAP70
12 positive regulation of alpha-beta T cell differentiation GO:0046638 9.49 PNP ZAP70
13 positive regulation of alpha-beta T cell proliferation GO:0046641 9.48 PTPRC ZAP70
14 positive regulation of isotype switching to IgG isotypes GO:0048304 9.46 IL2 PTPRC
15 positive regulation of T cell differentiation GO:0045582 9.43 IL2 PTPRC ZAP70
16 negative regulation of T cell mediated cytotoxicity GO:0001915 9.4 IL7R PTPRC
17 positive thymic T cell selection GO:0045059 9.33 CD3G PTPRC ZAP70
18 T cell activation GO:0042110 9.26 CD2 CD3G PTPRC ZAP70
19 T cell differentiation GO:0030217 9.1 CD3G IL2 IL7R PTPRC RHOH ZAP70

Sources for T Cell Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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