MCID: TCL003
MIFTS: 42

T Cell Deficiency

Categories: Immune diseases

Aliases & Classifications for T Cell Deficiency

MalaCards integrated aliases for T Cell Deficiency:

Name: T Cell Deficiency 12 15
T-Lymphocyte Deficiency 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11200
NCIt 50 C27872

Summaries for T Cell Deficiency

MalaCards based summary : T Cell Deficiency, also known as t-lymphocyte deficiency, is related to severe combined immunodeficiency and combined immunodeficiency, x-linked. An important gene associated with T Cell Deficiency is CD247 (CD247 Molecule), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs alemtuzumab and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and neutrophil, and related phenotypes are cellular and endocrine/exocrine gland

Wikipedia : 76 T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it... more...

Related Diseases for T Cell Deficiency

Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 severe combined immunodeficiency 28.8 IL2 IL7R PTPRC ZAP70
2 combined immunodeficiency, x-linked 28.1 CD3G IL2 IL7R PTPRC ZAP70
3 digeorge syndrome 11.1
4 t-cell receptor-alpha/beta deficiency 11.1
5 schimke immunoosseous dysplasia 10.8
6 immunodeficiency due to defect in mapbp-interacting protein 10.8
7 osteomyelitis, sterile multifocal, with periostitis and pustulosis 10.8
8 severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive 10.4 IL7R PTPRC
9 immunodeficiency 18 10.2 CD3G PTPRC
10 immunodeficiency 19 10.1 CD3G ZAP70
11 immunodeficiency 17 10.1 CD3G PTPRC
12 cd45 deficiency 10.1 PTPRC ZAP70
13 severe combined immunodeficiency, x-linked 9.9 IL2 IL7R
14 autoimmune lymphoproliferative syndrome 9.8 IL2 LRBA PTPRC
15 mucositis 9.8
16 common variable immunodeficiency 9.7
17 hepatitis 9.7
18 lymphopenia 9.7 CD3G IL2 IL7R
19 multiple sclerosis 9.7
20 systemic lupus erythematosus 9.7
21 anemia, autoimmune hemolytic 9.7
22 hematopoietic stem cell transplantation 9.7
23 hemolytic anemia 9.7
24 lupus erythematosus 9.7
25 hyper ige syndrome 9.7
26 hepatocellular carcinoma 9.5
27 cryoglobulinemia, familial mixed 9.5
28 schizophrenia 9.5
29 ataxia-telangiectasia 9.5
30 charge syndrome 9.5
31 myeloma, multiple 9.5
32 fabry disease 9.5
33 aging 9.5
34 dermatitis, atopic 9.5
35 pulmonary disease, chronic obstructive 9.5
36 wegener granulomatosis 9.5
37 cholangitis, primary sclerosing 9.5
38 graft-versus-host disease 9.5
39 adult t-cell leukemia 9.5
40 alopecia 9.5
41 arthritis 9.5
42 brain injury 9.5
43 cataract 9.5
44 chronic granulomatous disease 9.5
45 ectodermal dysplasia 9.5
46 glomerulonephritis 9.5
47 hepatitis b 9.5
48 leukemia 9.5
49 neutropenia 9.5
50 spinal cord injury 9.5

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to T Cell Deficiency

Symptoms & Phenotypes for T Cell Deficiency

MGI Mouse Phenotypes related to T Cell Deficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.96 IL2 IL7R LAMTOR2 PTPRC RHOH CD247
2 endocrine/exocrine gland MP:0005379 9.76 FOXN1 IL2 IL7R PTPRC RHOH CD247
3 hematopoietic system MP:0005397 9.65 IL2 IL7R LRBA PTPRC RHOH CD247
4 immune system MP:0005387 9.32 IL2 IL7R LRBA PTPRC RHOH CD247

Drugs & Therapeutics for T Cell Deficiency

Drugs for T Cell Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
alemtuzumab Approved, Investigational Phase 1, Phase 2 216503-57-0
2
Fludarabine Approved Phase 1, Phase 2,Phase 2 21679-14-1, 75607-67-9 30751
3 Antibodies Phase 1, Phase 2
4 Antibodies, Monoclonal Phase 1, Phase 2
5 Antimetabolites Phase 1, Phase 2
6 Antimetabolites, Antineoplastic Phase 1, Phase 2
7 Immunoglobulins Phase 1, Phase 2
8 Immunosuppressive Agents Phase 1, Phase 2
9 Acidophilus Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Allogeneic SCT Of Pts With SCID And Other Primary Immunodeficiency Disorders Terminated NCT00579137 Phase 1, Phase 2 Fludarabine
2 Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases Terminated NCT02231710 Phase 1
3 Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency Completed NCT00011141 Not Applicable Oral lactobacillus administration
4 Evaluation of HIV-Negative Patients With Low CD4+ T Lymphocyte Counts Completed NCT00001319

Search NIH Clinical Center for T Cell Deficiency

Genetic Tests for T Cell Deficiency

Anatomical Context for T Cell Deficiency

MalaCards organs/tissues related to T Cell Deficiency:

41
T Cells, B Cells, Neutrophil, Bone, Bone Marrow, Thymus, Liver

Publications for T Cell Deficiency

Articles related to T Cell Deficiency:

(show top 50) (show all 127)
# Title Authors Year
1
Regulatory T-cell deficiency leads to pathogenic bullous pemphigoid antigen 230 autoantibody and autoimmune bullous disease. ( 29704595 )
2018
2
Correction of T cell deficiency in ZAP-70 knockout mice by simple intraperitoneal adoptive transfer of thymocytes. ( 29431868 )
2018
3
Expansion of cytotoxic CD56(bright) natural killer cells during T-cell deficiency after allogeneic hematopoietic stem cell transplantation. ( 28778795 )
2017
4
Roles of Aluminum Hydroxide and Monophosphoryl Lipid A Adjuvants in Overcoming CD4+ T Cell Deficiency To Induce Isotype-Switched IgG Antibody Responses and Protection by T-Dependent Influenza Vaccine. ( 27881702 )
2017
5
Both mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition. ( 28385777 )
2017
6
Peripheral invariant natural killer T cell deficiency in metabolically unhealthy but normal weight versus metabolically healthy but obese individuals. ( 28322093 )
2016
7
Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on I^I'T cells in mice. ( 25791517 )
2015
8
T cell deficiency in spinal cord injury: altered locomotor recovery and whole-genome transcriptional analysis. ( 26546062 )
2015
9
Hypomorphic interleukin-7 receptor I+-chain mutations and T-cell deficiency: a delay in diagnosis. ( 26123418 )
2015
10
Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA. ( 25468195 )
2015
11
Syndrome of selective IgM deficiency with severe T cell deficiency associated with disseminated cutaneous mycobacterium avium intracellulaire infection. ( 26550546 )
2015
12
Mucosal-Associated Invariant T Cell Deficiency in Chronic Obstructive Pulmonary Disease. ( 26552490 )
2015
13
Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity. ( 26414901 )
2015
14
Blood dendritic cell levels associated with impaired IL-12 production and T-cell deficiency in patients with kidney disease: implications for post-transplant viral infections. ( 24963818 )
2014
15
Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. ( 25225673 )
2014
16
Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency. ( 24530773 )
2014
17
Additional B-cell deficiency does not affect growth and angiogenesis of ectopic human endometrium in T-cell-deficient endometriosis mouse models during long-term culture. ( 25270508 )
2014
18
Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency on antiretroviral therapy are associated with T-cell activation and senescence. ( 24499954 )
2014
19
Regulatory T-cell deficiency in rheumatic heart disease: a preliminary observational study. ( 23610999 )
2013
20
VI'2 T cell deficiency in granulomatosis with polyangiitis (Wegener's granulomatosis). ( 23891739 )
2013
21
Fine-tuning of regulatory T cell function: the role of calcium signals and naive regulatory T cells for regulatory T cell deficiency in multiple sclerosis. ( 23576680 )
2013
22
Impaired spatial memory in mice lacking CD3IP is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency. ( 24259588 )
2013
23
The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats. ( 23228347 )
2013
24
Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation. ( 23478176 )
2013
25
Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model. ( 22425450 )
2012
26
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. ( 22312480 )
2012
27
CD8 T cell deficiency impairs control of Epstein--Barr virus and worsens with age in multiple sclerosis. ( 21791511 )
2012
28
Ruling out HIV infection when testing for severe combined immunodeficiency and other T-cell deficiencies. ( 22386446 )
2012
29
Natural killer T cell deficiency in active adult-onset Still's Disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. ( 22605480 )
2012
30
CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. ( 22006994 )
2011
31
T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. ( 21492943 )
2011
32
IL-15 ex vivo overcomes CD4+ T cell deficiency for the induction of human antigen-specific CD8+ T cell responses. ( 21474552 )
2011
33
Invariant natural killer T-cell-deficient mice display increased CCla88 -induced hepatitis associated with CXCL1 over-expression and neutrophil infiltration. ( 21469102 )
2011
34
Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation. ( 20505149 )
2010
35
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. ( 20548030 )
2010
36
Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine. ( 20463106 )
2010
37
Profound invariant natural killer T-cell deficiency in inflammatory arthritis. ( 20444757 )
2010
38
A multiplex immunoassay using the Guthrie specimen to detect T-cell deficiencies including severe combined immunodeficiency disease. ( 20660143 )
2010
39
Newborn screening for T-cell deficiency. ( 20864885 )
2010
40
Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. ( 20103644 )
2010
41
Hematopoietic stem cell transplantation for profound T-cell deficiency (combined immunodeficiency). ( 20493397 )
2010
42
Can T-cell deficiency affect spatial learning ability following toluene exposure? ( 19923859 )
2010
43
Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency. ( 19664144 )
2009
44
Congenital T cell deficiency in a patient with CHARGE syndrome. ( 19187738 )
2009
45
Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. ( 19230472 )
2009
46
The effects of T cell deficiency on the development of worms and granuloma formation in mice infected with Schistosoma japonicum. ( 18246371 )
2008
47
Hepatitis and human bocavirus primary infection in a child with T-cell deficiency. ( 18842946 )
2008
48
Generating functional CD8+ T cell memory response under transient CD4+ T cell deficiency: implications for vaccination of immunocompromised individuals. ( 18506880 )
2008
49
Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15. ( 18465774 )
2008
50
Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency. ( 18667509 )
2008

Variations for T Cell Deficiency

Expression for T Cell Deficiency

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for T Cell Deficiency

Pathways related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CD247 CD3G IL2 IL7R LAMTOR2 PNP
2
Show member pathways
13.23 CD247 CD3G IL2 IL7R RHOH ZAP70
3
Show member pathways
13.14 CD247 CD3G IL2 RHOH ZAP70
4
Show member pathways
12.89 CD247 CD3G IL2 RHOH ZAP70
5
Show member pathways
12.71 CD247 CD3G IL2 PTPRC ZAP70
6
Show member pathways
12.28 CD247 CD3G IL2 ZAP70
7
Show member pathways
12.16 CD3G PTPRC ZAP70
8
Show member pathways
12.14 CD247 CD3G PTPRC ZAP70
9
Show member pathways
12.01 CD247 CD3G IL2
10
Show member pathways
11.88 CD247 CD3G IL2 ZAP70
11 11.83 IL2 IL7R PTPRC
12
Show member pathways
11.81 CD247 CD3G IL2
13
Show member pathways
11.76 CD247 CD3G IL2 PTPRC ZAP70
14 11.74 IL2 IL7R PTPRC
15 11.65 IL2 IL7R PTPRC
16 11.65 CD247 CD3G RHOH ZAP70
17 11.6 CD247 CD3G PTPRC
18
Show member pathways
11.6 CD247 CD3G PTPRC ZAP70
19 11.58 IL2 IL7R PTPRC
20 11.57 CD247 CD3G ZAP70
21 11.54 CD247 CD3G ZAP70
22
Show member pathways
11.49 CD247 CD3G PTPRC ZAP70
23 11.48 CD247 CD3G ZAP70
24
Show member pathways
11.44 CD247 CD3G IL2
25
Show member pathways
11.4 CD247 CD3G IL2 PTPRC ZAP70
26 11.33 CD247 CD3G ZAP70
27
Show member pathways
11.32 CD247 CD3G
28 11.19 CD247 CD3G
29 11.16 IL2 ZAP70
30 11.15 IL7R PTPRC ZAP70
31 11.13 IL2 ZAP70
32 11.04 CD247 IL2
33 10.94 CD247 CD3G IL2

GO Terms for T Cell Deficiency

Cellular components related to T Cell Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immunological synapse GO:0001772 9.16 RHOH ZAP70
2 alpha-beta T cell receptor complex GO:0042105 8.96 CD247 CD3G
3 T cell receptor complex GO:0042101 8.8 CD247 CD3G ZAP70

Biological processes related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.8 CD247 CD3G IL2 ZAP70
2 immune response GO:0006955 9.76 IL2 IL7R PNP ZAP70
3 cell surface receptor signaling pathway GO:0007166 9.67 CD247 CD3G IL7R PTPRC
4 adaptive immune response GO:0002250 9.62 CD247 CD3G IL2 ZAP70
5 positive regulation of B cell proliferation GO:0030890 9.51 IL2 PTPRC
6 B cell proliferation GO:0042100 9.48 IL7R PTPRC
7 positive regulation of T cell differentiation GO:0045582 9.43 IL2 ZAP70
8 positive regulation of T cell proliferation GO:0042102 9.43 IL2 PNP PTPRC
9 positive regulation of alpha-beta T cell differentiation GO:0046638 9.4 PNP ZAP70
10 T cell receptor signaling pathway GO:0050852 9.26 CD247 CD3G PTPRC ZAP70
11 negative regulation of T cell mediated cytotoxicity GO:0001915 9.16 IL7R PTPRC
12 T cell differentiation GO:0030217 9.02 IL2 IL7R PTPRC RHOH ZAP70

Sources for T Cell Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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