MCID: TCL003
MIFTS: 46

T Cell Deficiency

Categories: Immune diseases

Aliases & Classifications for T Cell Deficiency

MalaCards integrated aliases for T Cell Deficiency:

Name: T Cell Deficiency 12 15
T Lymphocyte Immunodeficiency 12
T-Lymphocyte Deficiency 71
T Cell Immunodeficiency 12
T Lymphocyte Deficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11200
SNOMED-CT 67 402792003
UMLS 71 C1274233 C1333147 C1744558

Summaries for T Cell Deficiency

Disease Ontology : 12 A primary immunodeficiency disease that is characterized by decreased numbers of circulating or functioning T cells.

MalaCards based summary : T Cell Deficiency, also known as t lymphocyte immunodeficiency, is related to immuno-osseous dysplasia and esophageal candidiasis. An important gene associated with T Cell Deficiency is IL7R (Interleukin 7 Receptor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Adenosine and rituximab have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are hematopoietic system and cellular

Wikipedia : 74 T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it... more...

Related Diseases for T Cell Deficiency

Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 541)
# Related Disease Score Top Affiliating Genes
1 immuno-osseous dysplasia 30.4 SMARCAL1 IL7R
2 esophageal candidiasis 30.3 CD8A CD4 CCR6
3 visceral leishmaniasis 30.2 IL2 IL15 CD28
4 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 30.1 PTPRC CD8A CD4
5 adult t-cell leukemia 30.1 IL2 IL15 CD4 CCR6
6 lymphoproliferative syndrome 30.1 PTPRC LRBA IL2 ICOSLG
7 cryptococcosis 30.1 CD8A CD4 CCR6
8 poliomyelitis 30.1 CD8A CD40LG CD4
9 tetanus 30.0 IL7R IL2 CD40LG CD247
10 epidermodysplasia verruciformis 1 30.0 IL7 CD8A CD4 CCR6
11 thymoma 30.0 PTPRC IL2 CD8A CD247
12 immune-complex glomerulonephritis 29.9 ICOSLG CD40LG CD4
13 adenosine deaminase deficiency 29.9 RAG1 IL2RG CD4
14 crohn's disease 29.9 IL2 ICOSLG CD4 CCR6
15 t-cell adult acute lymphocytic leukemia 29.9 IL2 CD8A CD4 CCR6
16 severe combined immunodeficiency, x-linked 29.9 IL7R IL7 IL2RG IL2 IL15
17 allergic hypersensitivity disease 29.9 IL2 ICOSLG CD4 CD28 CCR6
18 pneumocystosis 29.8 CD8A CD40LG CD4 CCR6
19 cholangitis, primary sclerosing 29.8 ICOSLG CD8A CD40LG CD4 CCR6
20 acquired immunodeficiency syndrome 29.8 IL2 IL15 CD40LG CD4 CCR6
21 intestinal disease 29.8 ICOSLG CD8A CD4 CCR6
22 orchitis 29.8 IL2 CD8A CD40LG CD4
23 pulmonary disease, chronic obstructive 29.7 ICOSLG CD8A CD4 CCR6
24 vitiligo-associated multiple autoimmune disease susceptibility 1 29.6 IL2 ICOSLG CD8A CD4 CCR6
25 thrombocytopenia due to platelet alloimmunization 29.6 ICOSLG CD8A CD40LG CD4 CCR6
26 systemic scleroderma 29.6 ICOSLG CD8A CD40LG CD4 CCR6
27 listeriosis 29.6 PTPRC IL7R IL2 ICOSLG CD8A CD4
28 chickenpox 29.6 IL2 CD8A CD40LG CD4 CCR6
29 dermatitis, atopic 29.6 IL2 ICOSLG CD8A CD4 CCR6
30 leprosy 3 29.5 IL2 CD8A CD40LG CD4 CCR6
31 autoimmune disease 29.5 ZAP70 IL2 IL15 ICOSLG CD40LG CD28
32 connective tissue disease 29.5 ICOSLG CD8A CD40LG CD4 CCR6
33 mycobacterium tuberculosis 1 29.5 PTPRC IL7 ICOSLG CD8A CD4 CCR6
34 aplastic anemia 29.4 IL2 IL15 CD4 CD28 CD247
35 stomatitis 29.4 IL2 CD40LG CD4
36 bacterial infectious disease 29.4 IL15 ICOSLG CD8A CD40LG CD4 CCR6
37 t-cell lymphoblastic leukemia/lymphoma 29.3 ZAP70 RAG1 PTPRC IL2 CD4 CD28
38 herpes zoster 29.3 IL2 ICOSLG CD8A CD40LG CD4 CCR6
39 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 29.3 LRBA IL7R IL2 ICOSLG CD8A CD4
40 granulomatosis with polyangiitis 29.3 IL7R ICOSLG CD40LG CD4 CD28 CCR6
41 progressive multifocal leukoencephalopathy 29.1 RAG1 IL2 ICOSLG CD8A CD40LG CD4
42 anemia, autoimmune hemolytic 29.0 ZAP70 LRBA IL2 ICOSLG CD8A CD40LG
43 skin disease 29.0 ZAP70 IL7 IL2 ICOSLG CD8A CD40LG
44 digeorge syndrome 29.0 RAG1 IL7 IL2RG FOXN1 CD8A CD40LG
45 lymphopenia 28.9 ZAP70 RAG1 IL7R IL7 IL2RG IL2
46 b cell deficiency 28.9 RAG1 LRBA IL2 ICOSLG CD8A CD40LG
47 common variable immunodeficiency 28.6 ZAP70 RAG1 LRBA IL7 IL2 IL15
48 sarcoidosis 1 28.6 PTPRC IL2 IL15 ICOSLG CD8A CD40LG
49 severe combined immunodeficiency 28.6 ZAP70 RAG1 PTPRC IL7R IL7 IL2RG
50 systemic lupus erythematosus 28.5 PTPRC IL7R IL2 IL15 ICOSLG CD8A

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to T Cell Deficiency

Symptoms & Phenotypes for T Cell Deficiency

MGI Mouse Phenotypes related to T Cell Deficiency:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 CCR6 CD247 CD28 CD4 CD40LG CD8A
2 cellular MP:0005384 10.25 CD247 CD28 CD4 CD40LG CD8A FOXN1
3 endocrine/exocrine gland MP:0005379 10.21 CD247 CD28 CD4 CD40LG CD8A FOXN1
4 immune system MP:0005387 10.21 CCR6 CD247 CD28 CD4 CD40LG CD8A
5 integument MP:0010771 9.81 CD28 CD4 CD40LG CD8A FOXN1 LAMTOR2
6 neoplasm MP:0002006 9.5 CD28 FOXN1 IL2 IL2RG IL7R PTPRC
7 normal MP:0002873 9.36 CCR6 CD247 CD28 CD4 CD8A FOXN1

Drugs & Therapeutics for T Cell Deficiency

Drugs for T Cell Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational Phase 2 58-61-7 60961
2
rituximab Approved Phase 2 174722-31-7 10201696
3
Busulfan Approved, Investigational Phase 2 55-98-1 2478
4
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
5
Pentostatin Approved, Investigational Phase 2 53910-25-1 439693 40926
6
Mycophenolic acid Approved Phase 2 24280-93-1 446541
7
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
8
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1
9
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
10
alemtuzumab Approved, Investigational Phase 1, Phase 2 216503-57-0
11 Molgramostim Investigational Phase 2 99283-10-0
12 Immunosuppressive Agents Phase 2
13 Alkylating Agents Phase 1, Phase 2
14 Antilymphocyte Serum Phase 1, Phase 2
15 Antirheumatic Agents Phase 2
16 Immunologic Factors Phase 2
17 Immunoglobulins Phase 1, Phase 2
18 Antibodies Phase 1, Phase 2
19 Antibodies, Monoclonal Phase 1, Phase 2
20 Antineoplastic Agents, Immunological Phase 1, Phase 2
21
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
22 Thymoglobulin Phase 1
23 Cyclosporins Phase 1
24 Anesthetics Phase 1
25 Calcium, Dietary Phase 1
26 Hormones Phase 1
27
Calcium Nutraceutical Phase 1 7440-70-2 271
28 Acidophilus

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Phase I/II Trial of De-Escalation of Busulfan With Fludarabine and Antithymocyte Globulin as Preparative Therapy for Hematopoietic Stem Cell Transplant for the Treatment of Severe Congenital T-Cell Immunodeficiency Completed NCT00228852 Phase 1, Phase 2 Busulfan, Fludarabine and ATG
2 Phase II Trial of Pentostatin, Cyclophosphamide and Rituximab (PCR) Followed by Campath-1H for Previously Treated Relapsed or Refractory Patients With Chronic Lymphocytic Leukemia Completed NCT00074282 Phase 2 cyclophosphamide;pentostatin;Alemtuzumab
3 Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies Recruiting NCT02579967 Phase 2 Immunosuppression Only Conditioning - Closed with amendment L;Reduced Intensity Conditioning;Myeloablative Conditioning-Closed with amendment L;GVHD Prophylaxis
4 Sargramostim to Reverse Myeloid Dendritic Cell Deficiency Terminated NCT03063242 Phase 2 Sargramostim
5 CD45 and Alemtuzumab Monoclonal Antibody Conditioning Regimen For Allogeneic Donor Stem Cell Transplantation Of Patients With Severe Combined Immunodeficiency Disease (SCID) And Other Primary Immunodeficiency Disorders Terminated NCT00579137 Phase 1, Phase 2 Fludarabine
6 Thymus Transplantation With Immunosuppression, #884 Completed NCT00579709 Phase 1
7 Parathyroid and Thymus Transplantation in DiGeorge Syndrome, #931 Completed NCT00566488 Phase 1
8 A Study Evaluating BPX-501 T Cells and AP1903 for Prevention of Graft Versus Host Disease (GVHD) After Haploidentical, Related, T Cell-Depleted Hematopoietic Cell Transplantation for Non-Malignant Diseases Active, not recruiting NCT02231710 Phase 1
9 Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency Completed NCT00011141 Oral lactobacillus administration
10 Developing Newborn Screening for Infants With Primary Immunodeficiency Completed NCT00113464
11 Retrospective Study of the Breadth of Donor Options for Patients With Inherited Diseases Requiring Allogeneic Hematopoietic Stem Cell Transplant in the Era of Alternative Donor Transplants Using Post-Transplantation Cyclophosphamide Completed NCT03188419
12 Sequential Transplantation of Umbilical Cord Blood Stem Cells and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency Type 1 Diabetes Mellitus Recruiting NCT03835312

Search NIH Clinical Center for T Cell Deficiency

Genetic Tests for T Cell Deficiency

Anatomical Context for T Cell Deficiency

MalaCards organs/tissues related to T Cell Deficiency:

40
T Cells, B Cells, Bone, Thymus, Bone Marrow, Liver, Skin

Publications for T Cell Deficiency

Articles related to T Cell Deficiency:

(show top 50) (show all 609)
# Title Authors PMID Year
1
Spontaneous antibody production caused by regulatory T cell deficiency occurs through a germinal center-independent pathway. 61
32430172 2020
2
Vitamin D status and the immune assessment in 22q11.2 deletion syndrome. 61
32149392 2020
3
Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia. 61
32556283 2020
4
Schimke immuno-osseous dysplasia, two new cases with peculiar EEG pattern. 61
32115305 2020
5
CD4+ T-Cell Responses Mediate Progressive Neurodegeneration in Experimental Ischemic Retinopathy. 61
32389572 2020
6
γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis. 61
32472066 2020
7
B Cells Inhibit CD4+ T Cell-Mediated Immunity to Brucella Infection in a Major Histocompatibility Complex Class II-Dependent Manner. 61
32071068 2020
8
Hypothesis: bipolar disorder is an Epstein-Barr virus-driven chronic autoimmune disease - implications for immunotherapy. 61
32257210 2020
9
CD8 T Cells and STAT1 Signaling Are Essential Codeterminants in Protection from Polyomavirus Encephalopathy. 61
31996425 2020
10
Impaired Release of Neutrophil Extracellular Traps and Anemia-Associated T Cell Deficiency in Hereditary Hemorrhagic Telangiectasia. 61
32178330 2020
11
Abnormal Newborn Screening Follow-up for Severe Combined Immunodeficiency in an Amish Cohort with Cartilage-Hair Hypoplasia. 61
31903518 2020
12
A First Case Report of DiGeorge Syndrome from Ethiopia Highlights Challenges in Identifying and Treating Children with Primary T-Cell Deficiencies in Low Resource Settings. 61
32158567 2020
13
In case of recurrent wheezing and bronchiolitis: Think again, it may be a primary immunodeficiency. 61
31837214 2019
14
T Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization, and Extracellular Matrix Remodeling. 61
31637099 2019
15
The Il9 CNS-25 Regulatory Element Controls Mast Cell and Basophil IL-9 Production. 61
31350354 2019
16
Prevalence of Epstein-Barr virus infection and characteristics of lymphocyte subsets in newly onset juvenile dermatomyositis. 61
31549298 2019
17
The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis. 61
31204070 2019
18
A case of Good's syndrome complicated by erythema multiforme. 61
31434669 2019
19
The accumulation of T cells within acellular nerve allografts is length-dependent and critical for nerve regeneration. 61
31085199 2019
20
CD4+ T Cell Regulation of Antibodies Cross-Reactive with Fungal Cell Wall-Associated Carbohydrates after Pneumocystis murina Infection. 61
31010812 2019
21
Tap water: A possible source of nontuberculous mycobacterial infection in patients with T cell deficiency. 61
30527279 2019
22
Clinical and immunological features in a cohort of patients with partial DiGeorge syndrome followed at a single center. 61
31015189 2019
23
Factors Beyond Lack of Antibody Govern Pulmonary Complications in Primary Antibody Deficiency. 61
31089938 2019
24
Immunodeficiency, Motor Delay, and Hypouricemia Caused by a Novel Mutation of Purine Nucleoside Phosphorylase Gene in an Indian Infant. 61
31007444 2019
25
Activation of T Lymphocytes as a Novel Mechanism in Beta1-Adrenergic Receptor Autoantibody-Induced Cardiac Remodeling. 61
30747396 2019
26
Small Numbers of CD4+ T Cells Can Induce Development of Lymphedema. 61
30601329 2019
27
Baboon envelope LVs efficiently transduced human adult, fetal, and progenitor T cells and corrected SCID-X1 T-cell deficiency. 61
30755435 2019
28
21st Century FOX: Toward Gene Therapy for the Regulatory T Cell Deficiency Syndrome IPEX. 61
30735648 2019
29
Decrease in αβ/γδ T-cell ratio is accompanied by a reduction in high-fat diet-induced weight gain, insulin resistance, and inflammation. 61
30285581 2019
30
T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation. 61
30241692 2019
31
Fetal Hydrops Secondary to in utero Pancytopenia. 61
29972823 2019
32
Mycobacteria-Specific T Cells May Be Expanded From Healthy Donors and Are Near Absent in Primary Immunodeficiency Disorders. 61
30984189 2019
33
T-Cell-Driven Inflammation as a Mediator of the Gut-Brain Axis Involved in Parkinson's Disease. 61
30828335 2019
34
Antibody Responses in HIV-Infected Patients With Advanced Immunosuppression and Asymptomatic Cryptococcal Antigenemia. 61
30648127 2019
35
Ataxia Telangiectasia Diagnosed on Newborn Screening-Case Cohort of 5 Years' Experience. 61
31921190 2019
36
Tregopathies: Monogenic diseases resulting in regulatory T-cell deficiency. 61
30527062 2018
37
Regulatory T-cell deficiency leads to pathogenic bullous pemphigoid antigen 230 autoantibody and autoimmune bullous disease. 61
29704595 2018
38
Regulatory T-cell deficiency and autoimmune skin disease: Beyond the scurfy mouse and immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. 61
30196121 2018
39
The contribution of immune activation and accelerated aging in multiple myeloma occurring in HIV-infected population. 61
30234600 2018
40
Newborn Screening for Severe Combined Immunodeficiency: Analytic and Clinical Performance of the T Cell Receptor Excision Circle Assay in France (DEPISTREC Study). 61
30251145 2018
41
CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS). 61
30036637 2018
42
CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection. 61
30372487 2018
43
Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner. 61
30373628 2018
44
Anti-mouse CD52 Treatment Ameliorates Colitis through Suppressing Th1/17 Mediated Inflammation and Promoting Tregs Differentiation in IL-10 Deficient Mice. 61
29899181 2018
45
Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity. 61
30170813 2018
46
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells. 61
30262807 2018
47
Control of Cytomegalovirus Viremia after Allogeneic Stem Cell Transplantation: A Review on CMV-Specific T Cell Reconstitution. 61
29626514 2018
48
Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta. 61
29448016 2018
49
Correction of T cell deficiency in ZAP-70 knock-out mice by simple intraperitoneal adoptive transfer of thymocytes. 61
29431868 2018
50
Dynamic changes in the immunological characteristics of T lymphocytes in surviving patients with severe fever with thrombocytopenia syndrome (SFTS). 61
29550447 2018

Variations for T Cell Deficiency

Expression for T Cell Deficiency

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for T Cell Deficiency

Pathways related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 ZAP70 RAG1 PTPRC LAMTOR2 IL7R IL7
2
Show member pathways
13.85 ZAP70 IL7R IL7 IL2RG IL2 IL15
3
Show member pathways
13.7 SMARCAL1 IL7R IL7 IL2RG IL2 IL15
4
Show member pathways
13.45 ZAP70 PTPRC ICOSLG CD8A CD40LG CD4
5
Show member pathways
13.39 RAG1 LAMTOR2 IL7R IL7 IL2RG IL2
6
Show member pathways
13.38 ZAP70 IL7R IL7 IL2RG IL2 IL15
7
Show member pathways
13.33 PTPRC IL7R IL7 IL2RG IL2 IL15
8
Show member pathways
12.92 ZAP70 PTPRC CD8A CD4 CD28 CD247
9
Show member pathways
12.87 IL2 IL15 ICOSLG CD8A CD40LG CD4
10 12.81 IL7R IL7 IL2RG IL2 IL15
11
Show member pathways
12.75 IL7R IL7 IL2RG IL2 IL15
12
Show member pathways
12.65 ZAP70 IL2RG IL2 CD4 CD28 CD247
13
Show member pathways
12.64 ZAP70 PTPRC IL2 ICOSLG CD40LG CD4
14 12.62 ZAP70 RAG1 PTPRC IL2 CD8A CD40LG
15
Show member pathways
12.55 ZAP70 PTPRC IL2 CD8A CD40LG CD4
16
Show member pathways
12.51 PTPRC IL7R IL7 IL2RG IL2 IL15
17
Show member pathways
12.42 ZAP70 PTPRC CD4 CD28
18
Show member pathways
12.33 ZAP70 PTPRC CD4 CD247
19 12.31 IL2RG IL2 IL15 CD4
20
Show member pathways
12.29 ZAP70 PTPRC IL2RG IL2 ICOSLG CD40LG
21
Show member pathways
12.21 ICOSLG CD4 CD28 CD247
22 12.16 PTPRC ICOSLG CD8A CD40LG CD4 CD28
23
Show member pathways
12.06 IL2RG IL2 CD8A CD4 CD247
24
Show member pathways
12.03 PTPRC IL7R IL7 IL2RG IL2 IL15
25
Show member pathways
12.01 ZAP70 IL2 CD247
26
Show member pathways
11.99 ZAP70 PTPRC CD4 CD247
27
Show member pathways
11.97 ZAP70 PTPRC CD8A CD4 CD28 CD247
28 11.94 IL7R IL7 CD8A CD4
29
Show member pathways
11.83 IL2RG CD4 CD28
30 11.82 PTPRC IL7R IL7 IL2 IL15 CD8A
31
Show member pathways
11.81 CD4 CD28 CD247
32 11.81 PTPRC IL7R IL2 CD8A CD4
33 11.79 ZAP70 CD8A CD4 CD28 CD247
34 11.74 PTPRC CD4 CD247
35
Show member pathways
11.71 IL2RG IL2 CD8A CD247
36 11.57 IL2RG IL2 CD4 CD28
37
Show member pathways
11.48 IL7R IL7 IL2RG
38 11.46 PTPRC IL7R IL7 IL2 IL15 CD8A
39
Show member pathways
11.39 IL2RG IL2 IL15
40 11.39 ZAP70 IL2 CD8A CD28
41 11.35 IL7 IL2 IL15 CD4
42 11.33 RAG1 IL7R IL7 IL2RG
43 11.32 IL2 CD4 CD28 CD247
44 11.28 ZAP70 IL2RG IL2 CD40LG CD28
45 10.81 ZAP70 RAG1 PTPRC IL7R IL2RG CD8A

GO Terms for T Cell Deficiency

Cellular components related to T Cell Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 ZAP70 PTPRC LRBA LAMTOR2 IL7R IL2RG
2 integral component of plasma membrane GO:0005887 9.87 PTPRC IL2RG CD8A CD40LG CD4 CD28
3 cell surface GO:0009986 9.5 PTPRC IL2RG IL15 CD40LG CD4 CD28
4 T cell receptor complex GO:0042101 9.46 ZAP70 CD8A CD4 CD247
5 external side of plasma membrane GO:0009897 9.28 PTPRC IL7R IL2RG ICOSLG CD8A CD40LG

Biological processes related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.09 ZAP70 IL2 ICOSLG CD8A CD4 CD28
2 cell surface receptor signaling pathway GO:0007166 9.97 PTPRC IL7R CD8A CD4 CD28 CD247
3 adaptive immune response GO:0002250 9.95 ZAP70 RAG1 IL2 ICOSLG CD8A CD4
4 regulation of immune response GO:0050776 9.93 ICOSLG CD8A CD40LG CD247
5 T cell receptor signaling pathway GO:0050852 9.85 ZAP70 PTPRC ICOSLG CD4 CD28 CD247
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 PTPRC IL15 CD4
7 B cell differentiation GO:0030183 9.81 RAG1 PTPRC CD40LG
8 humoral immune response GO:0006959 9.79 IL7 CD28 CCR6
9 T cell costimulation GO:0031295 9.77 ICOSLG CD40LG CD28
10 positive regulation of B cell proliferation GO:0030890 9.76 PTPRC IL7 IL2
11 B cell proliferation GO:0042100 9.75 PTPRC IL7R CD40LG
12 interleukin-7-mediated signaling pathway GO:0038111 9.74 IL7R IL7 IL2RG
13 regulation of defense response to virus by virus GO:0050690 9.73 CD4 CD28 CD247
14 positive regulation of T cell proliferation GO:0042102 9.73 PTPRC IL2 IL15 CD40LG CD4 CD28
15 T cell differentiation GO:0030217 9.72 ZAP70 PTPRC IL7R IL2 CD4
16 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.7 PTPRC CD4 CD28
17 interleukin-15-mediated signaling pathway GO:0035723 9.69 IL2RG IL15 CD4
18 positive regulation of interleukin-17 production GO:0032740 9.65 IL2 IL15
19 positive thymic T cell selection GO:0045059 9.65 ZAP70 PTPRC
20 negative thymic T cell selection GO:0045060 9.65 ZAP70 PTPRC CD28
21 interleukin-2-mediated signaling pathway GO:0038110 9.64 IL2RG IL2
22 negative regulation of T cell apoptotic process GO:0070233 9.63 RAG1 IL7R
23 positive regulation of isotype switching to IgG isotypes GO:0048304 9.63 PTPRC IL2 CD28
24 T cell migration GO:0072678 9.62 ZAP70 CCR6
25 positive regulation of tissue remodeling GO:0034105 9.61 IL2 IL15
26 T cell lineage commitment GO:0002360 9.61 IL7 FOXN1
27 positive regulation of alpha-beta T cell proliferation GO:0046641 9.61 ZAP70 PTPRC CD28
28 negative regulation of T cell mediated cytotoxicity GO:0001915 9.6 PTPRC IL7R
29 positive regulation of T cell differentiation GO:0045582 9.55 ZAP70 RAG1 PTPRC IL7 IL2
30 DN2 thymocyte differentiation GO:1904155 9.54 PTPRC CCR6
31 T cell activation GO:0042110 9.43 ZAP70 PTPRC ICOSLG CD8A CD4 CD28
32 immune response GO:0006955 9.4 ZAP70 RAG1 IL7R IL7 IL2RG IL2

Molecular functions related to T Cell Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.6 ZAP70 SMARCAL1 RAG1 PTPRC LRBA LAMTOR2
2 cytokine activity GO:0005125 9.56 IL7 IL2 IL15 CD40LG
3 coreceptor activity GO:0015026 9.33 CD8A CD4 CD28
4 interleukin-7 receptor activity GO:0004917 8.96 IL7R IL2RG

Sources for T Cell Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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