MCID: TCL002
MIFTS: 47

T-Cell Large Granular Lymphocyte Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for T-Cell Large Granular Lymphocyte Leukemia

MalaCards integrated aliases for T-Cell Large Granular Lymphocyte Leukemia:

Name: T-Cell Large Granular Lymphocyte Leukemia 12 15 74
Leukemia, Large Granular Lymphocytic 74
Large Granular Lymphocytic Leukemia 12
Leukemia Lymphocytic Large Granular 56

Classifications:



External Ids:

Disease Ontology 12 DOID:0050751

Summaries for T-Cell Large Granular Lymphocyte Leukemia

Disease Ontology : 12 A chronic lymphocytic leukemia that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood.

MalaCards based summary : T-Cell Large Granular Lymphocyte Leukemia, also known as leukemia, large granular lymphocytic, is related to large granular lymphocyte leukemia and natural killer cell leukemia. An important gene associated with T-Cell Large Granular Lymphocyte Leukemia is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ketamine and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and b cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disorder that exhibits an... more...

Related Diseases for T-Cell Large Granular Lymphocyte Leukemia

Diseases related to T-Cell Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 large granular lymphocyte leukemia 33.5 KIR2DL3 STAT3 STAT5B
2 natural killer cell leukemia 32.8 GZMB NCAM1
3 pure red-cell aplasia 30.8 IL2 STAT3
4 hematopoietic stem cell transplantation 30.0 IL2 KIR2DL1 KIR2DL3
5 aplastic anemia 29.6 FASLG IL2 STAT3
6 graft-versus-host disease 29.5 FASLG GZMB IL2
7 peripheral t-cell lymphoma 29.5 GZMB IL2 NCAM1
8 leukemia 11.1
9 lymphocytic leukemia 11.0
10 lymphoma 10.5
11 autoimmune lymphoproliferative syndrome, type v 10.4
12 hepatosplenic t-cell lymphoma 10.4
13 rheumatoid arthritis 10.3
14 sjogren syndrome 10.3
15 myelodysplastic syndrome 10.3
16 arthritis 10.3
17 neutropenia 10.3
18 heavy chain disease 10.3
19 gamma heavy chain disease 10.3
20 lymphoproliferative syndrome 10.3
21 prolymphocytic leukemia 10.3
22 splenomegaly 10.3
23 t-cell prolymphocytic leukemia 10.3
24 felty syndrome 10.3
25 anemia, autoimmune hemolytic 10.2
26 renal cell carcinoma, nonpapillary 10.1
27 systemic lupus erythematosus 10.1
28 hemochromatosis, type 1 10.1
29 aspergillosis 10.1
30 pulmonary hypertension 10.1
31 anaplastic large cell lymphoma 10.1
32 b-cell lymphomas 10.1
33 chronic myelomonocytic leukemia 10.1
34 crohn's disease 10.1
35 diffuse large b-cell lymphoma 10.1
36 hemolytic anemia 10.1
37 good syndrome 10.1
38 marantic endocarditis 10.1
39 endocarditis 10.1
40 protein-losing enteropathy 10.1
41 patulous eustachian tube 10.1
42 essential thrombocythemia 10.1
43 hairy cell leukemia 10.1
44 liposarcoma 10.1
45 pyoderma 10.1
46 t-cell leukemia 10.1
47 pyoderma gangrenosum 10.1
48 neuropathy 10.1
49 lupus erythematosus 10.1
50 amyloidosis 10.1

Graphical network of the top 20 diseases related to T-Cell Large Granular Lymphocyte Leukemia:



Diseases related to T-Cell Large Granular Lymphocyte Leukemia

Symptoms & Phenotypes for T-Cell Large Granular Lymphocyte Leukemia

GenomeRNAi Phenotypes related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

27 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.81 STAT5B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.81 IL18
3 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.81 KIR2DL1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.81 STAT5B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.81 STAT5B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.81 IL18
7 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.81 STAT5B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.81 KIR2DL1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.81 KIR2DL1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.81 IL18
11 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.81 KIR2DL1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.81 KIR2DL1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.81 IL18 KIR2DL1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.81 STAT5B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.81 IL18
16 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.81 KIR2DL1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.81 KIR2DL1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.81 STAT5B
19 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.81 KIR2DL1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.81 STAT5B
21 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.81 IL18
22 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.81 IL18
23 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.81 STAT5B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.81 IL18 KIR2DL1 STAT5B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.81 IL18
26 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.81 IL18
27 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.81 KIR2DL1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.81 KIR2DL1

Drugs & Therapeutics for T-Cell Large Granular Lymphocyte Leukemia

Drugs for T-Cell Large Granular Lymphocyte Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 242)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
2
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
3
Cefepime Approved, Investigational Phase 3 88040-23-7 5479537
4
Ofloxacin Approved Phase 3 82419-36-1 4583
5
Carboplatin Approved Phase 2, Phase 3,Phase 1 41575-94-4 10339178 38904 498142
6
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
7
Iron Approved, Experimental Phase 3,Phase 1,Phase 2,Not Applicable 7439-89-6, 15438-31-0 27284 23925
8
Darbepoetin alfa Approved, Investigational Phase 3,Phase 2 209810-58-2, 11096-26-7
9
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
10
Dalteparin Approved Phase 3 9005-49-6
11
Heparin Approved, Investigational Phase 3,Not Applicable 9005-49-6 46507594 772
12
Ondansetron Approved Phase 3,Not Applicable 99614-02-5 4595
13
Caspofungin Approved Phase 3,Phase 2 162808-62-0, 179463-17-3 2826718 468682
14
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
15
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
16
Guaifenesin Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 93-14-1 3516
17
Dextromethorphan Approved Phase 3 125-71-3 5362449 5360696
18
Morphine Approved, Investigational Phase 3,Not Applicable 57-27-2 5288826
19
Etoposide Approved Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable 33419-42-0 36462
20
Thiotepa Approved, Investigational Phase 2, Phase 3,Phase 1 52-24-4 5453
21
Fludarabine Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 75607-67-9, 21679-14-1 30751
22
Busulfan Approved, Investigational Phase 2, Phase 3,Early Phase 1 55-98-1 2478
23
Melphalan Approved Phase 2, Phase 3,Not Applicable 148-82-3 460612 4053
24
Ginseng Approved, Investigational, Nutraceutical Phase 3 50647-08-0
25 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
26 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Excitatory Amino Acids Phase 3
28 Anesthetics Phase 3
29 Anesthetics, Dissociative Phase 3
30 Neurotransmitter Agents Phase 3,Not Applicable
31 Excitatory Amino Acid Antagonists Phase 3
32 Analgesics Phase 3,Phase 2,Not Applicable
33 Anesthetics, Intravenous Phase 3
34 Anesthetics, General Phase 3
35 Central Nervous System Depressants Phase 3,Phase 1,Phase 2,Not Applicable
36 Anti-Infective Agents, Urinary Phase 3,Phase 1,Phase 2
37 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
38 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 1,Phase 2,Not Applicable
39 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
41 Cytochrome P-450 CYP1A2 Inhibitors Phase 3,Not Applicable
42 Renal Agents Phase 3,Phase 1,Phase 2
43 Cola Phase 3,Phase 1,Phase 2
44 Immunologic Factors Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable
45 Antirheumatic Agents Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable
46 Antineoplastic Agents, Alkylating Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable
47 Immunosuppressive Agents Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable
48 Alkylating Agents Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable
49 Narcotics Phase 3,Not Applicable
50 Analgesics, Opioid Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 126)
# Name Status NCT ID Phase Drugs
1 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
2 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
3 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
4 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
5 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
6 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
7 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
8 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
9 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
10 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
11 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
12 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
13 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
14 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
15 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
16 CAR-pNK Cell Immunotherapy in CD7 Positive Leukemia and Lymphoma Unknown status NCT02742727 Phase 1, Phase 2
17 Cyclosporine in Treating Patients With Low Blood Counts Caused By Hematologic Cancer Completed NCT00031980 Phase 2 cyclosporine
18 506U78 in Treating Patients With Chronic Lymphocytic Leukemia That Has Not Responded to Fludarabine or Alkylating Agents Completed NCT00003635 Phase 2 nelarabine
19 Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma Completed NCT01258998 Phase 2 Akt inhibitor MK2206
20 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
21 Donor Natural Killer Cells After Donor Stem Cell Transplant in Treating Patients With Advanced Cancer Completed NCT00823524 Phase 1, Phase 2
22 Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy Completed NCT00416624 Phase 2 darbepoetin alfa;epoetin alfa
23 Combination Chemotherapy Followed By Alemtuzumab in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia Completed NCT00278213 Phase 2 cyclophosphamide;fludarabine phosphate;mitoxantrone hydrochloride
24 Epoetin Alfa in Treating Patients With Anemia Who Are Undergoing Chemotherapy for Cancer Completed NCT00255749 Phase 2
25 Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic Cancer or Malignant Solid Tumor or Metastatic Breast Cancer Completed NCT00237627 Phase 1, Phase 2 PS-341;Doxil;Velcade
26 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
27 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Refractory Cancer Completed NCT00003406 Phase 1, Phase 2 carboplatin;docetaxel;ifosfamide
28 Interleukin-2 Plus Interferon Alfa in Treating Adults With Metastatic Cancer Completed NCT00002504 Phase 2
29 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00005804 Phase 2 cyclophosphamide
30 Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer or Hematologic Cancer Completed NCT00006225 Phase 1, Phase 2
31 Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia Recruiting NCT01976182 Phase 2 Methotrexate;Cyclophosphamide
32 A Dose-Ranging Study of IV BNZ-1 in LGL Leukemia or Refractory CTCL Recruiting NCT03239392 Phase 1, Phase 2 BNZ132-1-40
33 Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies Recruiting NCT01760655 Phase 2 Fludarabine phosphate;Thiotepa;Cyclophosphamide;Tacrolimus;Mycophenolate mofetil
34 A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Recruiting NCT01384513 Phase 2 Fludarabine;Busulfan;Cyclophosphamide (CY);Tacrolimus;Mycophenolate mofetil
35 Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or Malignancies Recruiting NCT00002663 Phase 1, Phase 2
36 Alemtuzumab (Campath ) to Treat T-Large Granular Lymphocyte Leukemia Active, not recruiting NCT00345345 Phase 2
37 Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies Active, not recruiting NCT01643603 Phase 1, Phase 2 Dasatinib
38 Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01839916 Phase 2
39 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01529827 Phase 2 fludarabine phosphate;melphalan;tacrolimus;mycophenolate mofetil;methotrexate
40 Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Active, not recruiting NCT00104858 Phase 2 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil
41 Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer Active, not recruiting NCT00006251 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
42 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant Active, not recruiting NCT00078858 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
43 Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies Active, not recruiting NCT00040846 Phase 2 fludarabine phosphate;mycophenolate mofetil;cyclosporine
44 Dasatinib for Modulating Immune System After Autologous Stem Cell Transplants for Multiple Myeloma, Non-Hodgkin, or Hodgkin Lymphoma Active, not recruiting NCT01609816 Phase 1, Phase 2 Dasatinib
45 Effect of Cyclosporine Therapy on Gene Expression in Patients With Large Granular Lymphocyte Leukemia Terminated NCT00363779 Phase 2 Cyclosporine
46 Methotrexate Followed by Fludarabine in Patients With T-Cell Large Granular Lymphocytic Leukemia Terminated NCT00278265 Phase 2 MTX followed by fludarabine
47 Alemtuzumab in Myelodysplastic Syndrome (MDS), Aplastic Anemia, and T-Cell Large Granular Lymphocytic Leukemia (T-GL) Terminated NCT01191749 Phase 2 Alemtuzumab
48 Tipifarnib in Treating Patients With Anemia or Neutropenia and Large Granular Lymphocyte Leukemia Terminated NCT00360776 Phase 2 tipifarnib
49 Ipilimumab and Local Radiation Therapy in Treating Patients With Recurrent Melanoma, Non-Hodgkin Lymphoma, Colon, or Rectal Cancer Terminated NCT01769222 Phase 1, Phase 2
50 Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant Terminated NCT01419795 Phase 2 lenalidomide

Search NIH Clinical Center for T-Cell Large Granular Lymphocyte Leukemia

Genetic Tests for T-Cell Large Granular Lymphocyte Leukemia

Anatomical Context for T-Cell Large Granular Lymphocyte Leukemia

MalaCards organs/tissues related to T-Cell Large Granular Lymphocyte Leukemia:

42
T Cells, Bone Marrow, B Cells, Kidney, Nk Cells, Colon, Testis

Publications for T-Cell Large Granular Lymphocyte Leukemia

Articles related to T-Cell Large Granular Lymphocyte Leukemia:

(show top 50) (show all 61)
# Title Authors Year
1
Complete remission of agranulocytosis after splenectomy in a variant form of T-cell large granular lymphocyte leukemia. ( 29963929 )
2018
2
Management of T-cell large granular lymphocyte leukemia and concurrent retroperitoneal liposarcoma. ( 30057739 )
2018
3
T-cell large granular lymphocyte leukemia transformation into aggressive T-cell lymphoma: a report of two cases with molecular characterization. ( 30573508 )
2018
4
Donor derived T-cell large granular lymphocyte leukemia after cord blood transplant for pediatric T-cell lymphoblastic leukemia. ( 29269802 )
2018
5
Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRγδ+ T cell large granular lymphocyte leukemia. ( 28407008 )
2017
6
Hematopoietic stem cell transplantation for T-cell large granular lymphocyte leukemia: a retrospective study of the European Society for Blood and Marrow Transplantation. ( 26460210 )
2016
7
T-Cell Large Granular Lymphocyte Leukemia in the Lower Eyelid. ( 25198396 )
2016
8
High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. ( 27697773 )
2016
9
Good syndrome presenting with CD8⁺ T-Cell large granular lymphocyte leukemia. ( 26429871 )
2015
10
Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. ( 25396761 )
2015
11
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia. ( 24756696 )
2014
12
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRαβ(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. ( 24413066 )
2014
13
Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. ( 24649974 )
2014
14
Distinct effect of cyclophosphamide and cyclosporine on pure red cell aplasia associated with T-cell large granular lymphocyte leukemia. ( 25466263 )
2014
15
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. ( 23395383 )
2013
16
T-cell large granular lymphocyte leukemia in a child with anemia and Crohn's disease. ( 23409990 )
2013
17
Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. ( 23869084 )
2013
18
Increased serum soluble IL-15Rα levels in T-cell large granular lymphocyte leukemia. ( 22049515 )
2012
19
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. ( 22859607 )
2012
20
Lymphocytosis: T-cell large granular lymphocyte leukemia. ( 23082329 )
2012
21
Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype. ( 24765467 )
2012
22
Imatinib mesylate in T-cell large granular lymphocyte leukemia associated with chronic graft-versus-host disease. ( 21663506 )
2011
23
A case of concomitant T-cell large granular lymphocyte leukemia and plasma cell myeloma. ( 22252668 )
2011
24
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. ( 19660811 )
2010
25
Long-term safety and efficacy of cyclosporin A therapy for T-cell large granular lymphocyte leukemia. ( 20038217 )
2010
26
T-cell large granular lymphocyte leukemia: an Asian perspective. ( 20084380 )
2010
27
Rapid and durable molecular response of refractory T-cell large granular lymphocyte leukemia after alemtuzumab treatment. ( 20211489 )
2010
28
MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia. ( 20460636 )
2010
29
Lessons learned from an unusual presentation of CD3+, CD56- T-cell large granular lymphocyte leukemia. ( 20679608 )
2010
30
T-cell large granular lymphocyte leukemia presenting as end-stage renal disease: the diagnostic role of flow-cytometric and clonality analysis of the urine sediment. ( 19203516 )
2009
31
T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases. ( 19228641 )
2009
32
Protein-losing enteropathy due to T-cell large granular lymphocyte leukemia. ( 19307498 )
2009
33
T cell large granular lymphocyte leukemia associated with rheumatoid arthritis and neutropenia. ( 19394280 )
2009
34
CD20-positive T-cell large granular lymphocyte leukemia: case report and review of the literature. ( 19687595 )
2009
35
Outcomes of splenectomy in T-cell large granular lymphocyte leukemia with splenomegaly and cytopenia. ( 18550263 )
2008
36
The gammadelta variant of T cell large granular lymphocyte leukemia is very similar to the common alphabeta type: report of two cases. ( 19669213 )
2008
37
CD20- and CD56-positive T-cell large granular lymphocyte leukemia in a human T-cell leukemia virus type 1 carrier. ( 18055343 )
2007
38
Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. ( 17205534 )
2007
39
Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia. ( 17525720 )
2007
40
Malignant transformation of T-cell large granular lymphocyte leukemia in a dog. ( 17611371 )
2007
41
T-cell large granular lymphocyte leukemia: a cause of complex aphthosis not to be missed. ( 17637384 )
2007
42
T-cell large granular lymphocyte leukemia of donor origin after cord blood transplantation. ( 17875238 )
2007
43
Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia. ( 16387851 )
2006
44
Characterization of T-cell large granular lymphocyte leukemia associated with Sjogren's syndrome-an important but under-recognized association. ( 16616153 )
2006
45
T-cell large granular lymphocyte leukemia: A report on the treatment of 29 patients and a review of the literature. ( 16795070 )
2006
46
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. ( 15958859 )
2005
47
CD52 expression in T-cell large granular lymphocyte leukemia--implications for treatment with alemtuzumab. ( 16019510 )
2005
48
Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56+ T-cell large granular lymphocyte leukemia. ( 14712486 )
2004
49
T-cell large granular lymphocyte leukemia and related disorders. ( 15169980 )
2004
50
Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia. ( 15304606 )
2004

Variations for T-Cell Large Granular Lymphocyte Leukemia

Expression for T-Cell Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for T-Cell Large Granular Lymphocyte Leukemia.

Pathways for T-Cell Large Granular Lymphocyte Leukemia

Pathways related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 FASLG IL18 IL2 KIR2DL1 KIR2DL3 MICA
2
Show member pathways
13.17 FASLG IL18 IL2 STAT3 STAT5B
3
Show member pathways
13.08 FASLG IL18 IL2 NCAM1 STAT3 STAT5B
4
Show member pathways
12.75 FASLG MICA STAT3 STAT5B
5 12.62 FASLG IL2 STAT3 STAT5B
6
Show member pathways
12.44 FASLG GZMB IL18 IL2 KIR2DL1 KIR2DL3
7
Show member pathways
12.36 IL18 IL2 STAT3 STAT5B
8
Show member pathways
12.34 IL18 IL2 STAT3 STAT5B
9
Show member pathways
12.3 FASLG GZMB STAT3
10 12.25 FASLG GZMB IL2 NCAM1 STAT3 STAT5B
11
Show member pathways
12.22 IL2 STAT3 STAT5B
12
Show member pathways
12.18 FASLG STAT3 STAT5B
13
Show member pathways
12.01 FASLG STAT3 STAT5B
14 11.91 NCAM1 STAT3 STAT5B
15
Show member pathways
11.91 FASLG GZMB IL2 KIR2DL1 KIR2DL3 MICA
16 11.87 KIR2DL1 KIR2DL3 MICA
17
Show member pathways
11.86 IL2 STAT3 STAT5B
18
Show member pathways
11.78 IL18 IL2 STAT3 STAT5B
19 11.77 FASLG IL18 STAT3
20 11.67 IL2 STAT3 STAT5B
21 11.53 GZMB IL18 IL2 NCAM1
22
Show member pathways
11.48 FASLG IL2 STAT5B
23
Show member pathways
11.42 FASLG GZMB IL2
24 11.37 STAT3 STAT5B
25 11.36 IL18 STAT3
26 11.33 NCAM1 STAT5B
27 11.33 STAT3 STAT5B
28
Show member pathways
11.32 STAT3 STAT5B
29
Show member pathways
11.27 STAT3 STAT5B
30
Show member pathways
11.25 STAT3 STAT5B
31 11.24 STAT3 STAT5B
32
Show member pathways
11.22 STAT3 STAT5B
33 11.19 FASLG IL18
34
Show member pathways
11.07 STAT3 STAT5B
35
Show member pathways
11.07 FASLG GZMB IL18 IL2 STAT3
36 11.03 IL18 IL2 STAT3
37 11.01 FASLG IL18 IL2
38 10.86 STAT3 STAT5B

GO Terms for T-Cell Large Granular Lymphocyte Leukemia

Biological processes related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.86 FASLG IL2 STAT3 STAT5B
2 cell-cell signaling GO:0007267 9.79 FASLG IL18 IL2
3 MAPK cascade GO:0000165 9.78 IL18 IL2 NCAM1
4 regulation of immune response GO:0050776 9.77 KIR2DL1 KIR2DL3 MICA
5 cellular response to hormone stimulus GO:0032870 9.63 STAT3 STAT5B
6 positive regulation of inflammatory response GO:0050729 9.63 IL18 IL2 STAT5B
7 positive regulation of interferon-gamma production GO:0032729 9.62 IL18 IL2
8 regulation of cell adhesion GO:0030155 9.62 IL18 STAT5B
9 positive regulation of erythrocyte differentiation GO:0045648 9.59 STAT3 STAT5B
10 interleukin-7-mediated signaling pathway GO:0038111 9.58 STAT3 STAT5B
11 regulation of multicellular organism growth GO:0040014 9.58 STAT3 STAT5B
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IL18 IL2 STAT3
13 JAK-STAT cascade GO:0007259 9.57 STAT3 STAT5B
14 cytolysis GO:0019835 9.55 GZMB MICA
15 interleukin-15-mediated signaling pathway GO:0035723 9.54 STAT3 STAT5B
16 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.52 STAT3 STAT5B
17 positive regulation of interleukin-17 production GO:0032740 9.51 IL18 IL2
18 natural killer cell activation GO:0030101 9.5 IL18 IL2 MICA
19 interleukin-2-mediated signaling pathway GO:0038110 9.49 IL2 STAT5B
20 interleukin-9-mediated signaling pathway GO:0038113 9.48 STAT3 STAT5B
21 positive regulation of natural killer cell proliferation GO:0032819 9.43 IL18 STAT5B
22 positive regulation of activated T cell proliferation GO:0042104 9.43 IL18 IL2 STAT5B
23 positive regulation of tissue remodeling GO:0034105 9.37 IL18 IL2
24 cytokine-mediated signaling pathway GO:0019221 9.35 FASLG IL18 IL2 STAT3 STAT5B
25 natural killer cell mediated cytotoxicity GO:0042267 9.33 GZMB IL18 MICA
26 immune response GO:0006955 9.1 FASLG IL18 IL2 KIR2DL1 KIR2DL3 MICA

Molecular functions related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 FASLG IL18 IL2
2 glucocorticoid receptor binding GO:0035259 8.62 STAT3 STAT5B

Sources for T-Cell Large Granular Lymphocyte Leukemia

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
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70 SNOMED-CT via HPO
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75 UMLS via Orphanet
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