MCID: TCL002
MIFTS: 47

T-Cell Large Granular Lymphocyte Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for T-Cell Large Granular Lymphocyte Leukemia

MalaCards integrated aliases for T-Cell Large Granular Lymphocyte Leukemia:

Name: T-Cell Large Granular Lymphocyte Leukemia 12 15 73
Leukemia, Large Granular Lymphocytic 73
Large Granular Lymphocytic Leukemia 12
Leukemia Lymphocytic Large Granular 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0050751

Summaries for T-Cell Large Granular Lymphocyte Leukemia

Disease Ontology : 12 A chronic lymphocytic leukemia that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood.

MalaCards based summary : T-Cell Large Granular Lymphocyte Leukemia, also known as leukemia, large granular lymphocytic, is related to large granular lymphocyte leukemia and pure red-cell aplasia. An important gene associated with T-Cell Large Granular Lymphocyte Leukemia is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ketamine and Cefepime have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotype is vision/eye.

Wikipedia : 76 Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disorder that exhibits an... more...

Related Diseases for T-Cell Large Granular Lymphocyte Leukemia

Diseases related to T-Cell Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 large granular lymphocyte leukemia 34.0 STAT3 STAT5B
2 pure red-cell aplasia 30.7 IL2 STAT3
3 graft-versus-host disease 29.4 FASLG GZMB IL2
4 peripheral t-cell lymphoma 29.3 GZMB IL2 NCAM1
5 leukemia 10.9
6 lymphoma 10.4
7 breast medullary carcinoma 10.3 FASLG GZMB
8 chronic nk-cell lymphocytosis 10.3 FASLG NCAM1
9 lymphocytic gastritis 10.3 FASLG GZMB
10 orbit lymphoma 10.3 GZMB NCAM1
11 lymphomatoid papulosis 10.3 FASLG GZMB
12 choriocarcinoma of the testis 10.2 FASLG GZMB
13 jak3-deficient severe combined immunodeficiency 10.2 IL2 STAT5B
14 subcutaneous panniculitis-like t-cell lymphoma 10.2 GZMB NCAM1
15 autoimmune lymphoproliferative syndrome, type v 10.2
16 hepatosplenic t-cell lymphoma 10.2
17 supratentorial primitive neuroectodermal tumor 10.2 IER3IP1 NCAM1
18 rheumatoid arthritis 10.1
19 myelodysplastic syndrome 10.1
20 arthritis 10.1
21 b-cell lymphomas 10.1
22 neutropenia 10.1
23 heavy chain disease 10.1
24 gamma heavy chain disease 10.1
25 prolymphocytic leukemia 10.1
26 t-cell leukemia 10.1
27 splenomegaly 10.1
28 t-cell prolymphocytic leukemia 10.1
29 bone fracture 10.1 IL2 STAT3
30 panniculitis 10.1 GZMB NCAM1
31 sialolithiasis 10.1 FASLG GZMB
32 lung lymphoma 10.1 GZMB NCAM1
33 systemic lupus erythematosus 10.0
34 sjogren syndrome 10.0
35 aging 10.0
36 anaplastic large cell lymphoma 10.0
37 chronic myelomonocytic leukemia 10.0
38 crohn's disease 10.0
39 diffuse large b-cell lymphoma 10.0
40 hematopoietic stem cell transplantation 10.0
41 hemolytic anemia 10.0
42 good syndrome 10.0
43 lymphoblastic leukemia 10.0
44 protein-losing enteropathy 10.0
45 essential thrombocythemia 10.0
46 hairy cell leukemia 10.0
47 neuropathy 10.0
48 lupus erythematosus 10.0
49 chronic graft versus host disease 10.0
50 human t-cell leukemia virus type 1 10.0

Graphical network of the top 20 diseases related to T-Cell Large Granular Lymphocyte Leukemia:



Diseases related to T-Cell Large Granular Lymphocyte Leukemia

Symptoms & Phenotypes for T-Cell Large Granular Lymphocyte Leukemia

MGI Mouse Phenotypes related to T-Cell Large Granular Lymphocyte Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 FASLG IL18 IL2 NCAM1 STAT3

Drugs & Therapeutics for T-Cell Large Granular Lymphocyte Leukemia

Drugs for T-Cell Large Granular Lymphocyte Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 237)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
2
Cefepime Approved, Investigational Phase 3 88040-23-7 5479537
3
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
4
Ofloxacin Approved Phase 3 82419-36-1 4583
5
Carboplatin Approved Phase 2, Phase 3,Phase 1 41575-94-4 10339178 498142 38904
6
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
7
Darbepoetin alfa Approved, Investigational Phase 3,Phase 2 11096-26-7, 209810-58-2
8
Iron Approved Phase 3,Phase 1,Phase 2,Not Applicable 7439-89-6 23925
9
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
10
Dalteparin Approved Phase 3 9005-49-6
11
Heparin Approved, Investigational Phase 3,Not Applicable 9005-49-6 772 46507594
12
Ondansetron Approved Phase 3,Not Applicable 99614-02-5 4595
13
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
14
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
15
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
16
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
17
Guaifenesin Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 93-14-1 3516
18
Morphine Approved, Investigational Phase 3,Not Applicable 57-27-2 5288826
19
Busulfan Approved, Investigational Phase 2, Phase 3,Early Phase 1 55-98-1 2478
20
Etoposide Approved Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable 33419-42-0 36462
21
Fludarabine Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 21679-14-1, 75607-67-9 30751
22
Thiotepa Approved, Investigational Phase 2, Phase 3,Phase 1 52-24-4 5453
23
Melphalan Approved Phase 2, Phase 3,Not Applicable 148-82-3 4053 460612
24
Ginseng Approved, Investigational, Nutraceutical Phase 3 50647-08-0
25 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
26 Analgesics Phase 3,Phase 2,Not Applicable
27 Anesthetics Phase 3
28 Anesthetics, Dissociative Phase 3
29 Anesthetics, General Phase 3
30 Anesthetics, Intravenous Phase 3
31 Central Nervous System Depressants Phase 3,Phase 1,Phase 2,Not Applicable
32 Excitatory Amino Acid Antagonists Phase 3
33 Excitatory Amino Acids Phase 3
34 Neurotransmitter Agents Phase 3,Phase 1,Not Applicable
35 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable
36 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
37 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
38 Cephalosporins Phase 3
39 Cytochrome P-450 CYP1A2 Inhibitors Phase 3,Not Applicable
40 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 1,Phase 2,Not Applicable
41 Renal Agents Phase 3,Phase 1,Phase 2
42 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
43 Dermatologic Agents Phase 3,Phase 2,Phase 1,Not Applicable
44 Alkylating Agents Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable
45 Antimetabolites Phase 2, Phase 3,Phase 1,Not Applicable
46 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 1,Not Applicable
47 Antineoplastic Agents, Alkylating Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable
48 Antirheumatic Agents Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable
49 Immunosuppressive Agents Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable
50 Analgesics, Opioid Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 123)
# Name Status NCT ID Phase Drugs
1 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
2 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
3 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
4 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
5 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
6 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
7 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
8 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
9 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
10 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
11 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
12 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
13 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
14 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
15 Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia Unknown status NCT01976182 Phase 2 Methotrexate;Cyclophosphamide
16 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
17 Cyclosporine in Treating Patients With Low Blood Counts Caused By Hematologic Cancer Completed NCT00031980 Phase 2 cyclosporine
18 506U78 in Treating Patients With Chronic Lymphocytic Leukemia That Has Not Responded to Fludarabine or Alkylating Agents Completed NCT00003635 Phase 2 nelarabine
19 Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma Completed NCT01258998 Phase 2 Akt inhibitor MK2206
20 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
21 Donor Natural Killer Cells After Donor Stem Cell Transplant in Treating Patients With Advanced Cancer Completed NCT00823524 Phase 1, Phase 2
22 Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy Completed NCT00416624 Phase 2 darbepoetin alfa;epoetin alfa
23 Combination Chemotherapy Followed By Alemtuzumab in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia Completed NCT00278213 Phase 2 cyclophosphamide;fludarabine phosphate;mitoxantrone hydrochloride
24 Epoetin Alfa in Treating Patients With Anemia Who Are Undergoing Chemotherapy for Cancer Completed NCT00255749 Phase 2
25 Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic Cancer or Malignant Solid Tumor or Metastatic Breast Cancer Completed NCT00237627 Phase 1, Phase 2 PS-341;Doxil;Velcade
26 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
27 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Refractory Cancer Completed NCT00003406 Phase 1, Phase 2 carboplatin;docetaxel;ifosfamide
28 Interleukin-2 Plus Interferon Alfa in Treating Adults With Metastatic Cancer Completed NCT00002504 Phase 2
29 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00005804 Phase 2 cyclophosphamide
30 Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer or Hematologic Cancer Completed NCT00006225 Phase 1, Phase 2
31 A Dose-Ranging Study of IV BNZ-1 in LGL Leukemia or Refractory CTCL Recruiting NCT03239392 Phase 1, Phase 2 BNZ132-1-40
32 Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies Recruiting NCT01643603 Phase 1, Phase 2 Dasatinib
33 Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies Recruiting NCT01760655 Phase 2 Fludarabine phosphate;Thiotepa;Cyclophosphamide;Tacrolimus;Mycophenolate mofetil
34 A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Recruiting NCT01384513 Phase 2 Fludarabine;Busulfan;Cyclophosphamide (CY);Tacrolimus;Mycophenolate mofetil
35 Dasatinib for Modulating Immune System After Autologous Stem Cell Transplants for Multiple Myeloma, Non-Hodgkin, or Hodgkin Lymphoma Recruiting NCT01609816 Phase 1, Phase 2 Dasatinib
36 CAR-pNK Cell Immunotherapy in CD7 Positive Leukemia and Lymphoma Recruiting NCT02742727 Phase 1, Phase 2
37 Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or Malignancies Recruiting NCT00002663 Phase 1, Phase 2
38 Alemtuzumab (Campath ) to Treat T-Large Granular Lymphocyte Leukemia Active, not recruiting NCT00345345 Phase 2 Alemtuzumab (Campath)
39 Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01839916 Phase 2
40 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01529827 Phase 2 fludarabine phosphate;melphalan;tacrolimus;mycophenolate mofetil;methotrexate
41 Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Active, not recruiting NCT00104858 Phase 2 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil
42 Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer Active, not recruiting NCT00006251 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
43 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant Active, not recruiting NCT00078858 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
44 Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies Active, not recruiting NCT00040846 Phase 2 fludarabine phosphate;mycophenolate mofetil;cyclosporine
45 Effect of Cyclosporine Therapy on Gene Expression in Patients With Large Granular Lymphocyte Leukemia Terminated NCT00363779 Phase 2 Cyclosporine
46 Methotrexate Followed by Fludarabine in Patients With T-Cell Large Granular Lymphocytic Leukemia Terminated NCT00278265 Phase 2 MTX followed by fludarabine
47 Alemtuzumab in Myelodysplastic Syndrome (MDS), Aplastic Anemia, and T-Cell Large Granular Lymphocytic Leukemia (T-GL) Terminated NCT01191749 Phase 2 Alemtuzumab
48 Tipifarnib in Treating Patients With Anemia or Neutropenia and Large Granular Lymphocyte Leukemia Terminated NCT00360776 Phase 2 tipifarnib
49 Ipilimumab and Local Radiation Therapy in Treating Patients With Recurrent Melanoma, Non-Hodgkin Lymphoma, Colon, or Rectal Cancer Terminated NCT01769222 Phase 1, Phase 2
50 Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant Terminated NCT01419795 Phase 2 lenalidomide

Search NIH Clinical Center for T-Cell Large Granular Lymphocyte Leukemia

Genetic Tests for T-Cell Large Granular Lymphocyte Leukemia

Anatomical Context for T-Cell Large Granular Lymphocyte Leukemia

MalaCards organs/tissues related to T-Cell Large Granular Lymphocyte Leukemia:

41
T Cells, Bone, Bone Marrow, Liver, Kidney, B Cells, Colon

Publications for T-Cell Large Granular Lymphocyte Leukemia

Articles related to T-Cell Large Granular Lymphocyte Leukemia:

(show top 50) (show all 79)
# Title Authors Year
1
Complete remission of agranulocytosis after splenectomy in a variant formA of T-cell large granular lymphocyte leukemia. ( 29963929 )
2018
2
Pure red cell aplasia with t-cell large granular lymphocytic leukemia. ( 29921385 )
2018
3
T-Cell Large Granular Lymphocytic Leukemia and Coexisting B-Cell Lymphomas: A Study From the Bone Marrow Pathology Group. ( 29365010 )
2018
4
Distinguishing Between Hepatosplenic T-cell Lymphoma and I^I' T-cell Large Granular Lymphocytic Leukemia: A Clinicopathologic, Immunophenotypic, and Molecular Analysis. ( 27755009 )
2017
5
Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRI^I'+ T cell large granular lymphocyte leukemia. ( 28407008 )
2017
6
Donor derived T-cell large granular lymphocyte leukemia after cord blood transplant for pediatric T-cell lymphoblastic leukemia. ( 29269802 )
2017
7
High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. ( 27697773 )
2016
8
Donor-Derived T-Cell Large Granular Lymphocytic Leukemia in a Patient With Peripheral T-Cell Lymphoma. ( 27496109 )
2016
9
Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature. ( 26875967 )
2016
10
Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. ( 26199174 )
2016
11
Moderate-dose cyclophosphamide in the treatment of relapsed/refractory T-cell large granular lymphocytic leukemia-associated pure red cell aplasia. ( 27077768 )
2016
12
Hematopoietic stem cell transplantation for T-cell large granular lymphocyte leukemia: a retrospective study of the European Society for Blood and Marrow Transplantation. ( 26460210 )
2015
13
Good syndrome presenting with CD8+ T-Cell large granular lymphocyte leukemia. ( 26429871 )
2015
14
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. ( 25238936 )
2014
15
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. ( 24413066 )
2014
16
Coexistence of ALK-anaplastic large cell lymphoma and CD4+ T cell large granular lymphocytic leukemia. ( 25100004 )
2014
17
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia. ( 24756696 )
2014
18
Distinct effect of cyclophosphamide and cyclosporine on pure red cell aplasia associated with T-cell large granular lymphocyte leukemia. ( 25466263 )
2014
19
Guidelines for NHL: updates to the management of diffuse large B-cell lymphoma and new guidelines for primary cutaneous CD30+ T-cell lymphoproliferative disorders and T-cell large granular lymphocytic leukemia. ( 24853220 )
2014
20
T-Cell Large Granular Lymphocyte Leukemia in the Lower Eyelid. ( 25198396 )
2014
21
Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. ( 24649974 )
2014
22
Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. ( 25396761 )
2014
23
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. ( 23563237 )
2013
24
T-cell large granular lymphocyte leukemia in a child with anemia and Crohn's disease. ( 23409990 )
2013
25
CD4(-)/CD8(-) variant of T-cell large granular lymphocytic leukemia or hepatosplenic T-cell lymphoma: a clinicopathologic dilemma. ( 23800602 )
2013
26
Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. ( 23869084 )
2013
27
STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia. ( 24283217 )
2013
28
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. ( 23395383 )
2013
29
Unusual concurrence of T-cell large granular lymphocytic leukemia with Franklin disease (gamma heavy chain disease) manifested with massive splenomegaly. ( 22694793 )
2013
30
Lymphocytosis: T-cell large granular lymphocyte leukemia. ( 23082329 )
2012
31
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. ( 22859607 )
2012
32
Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype. ( 24765467 )
2012
33
Differential diagnosis of CD4-/CD8- I^I' T-cell large granular lymphocytic leukemia and hepatosplenic T-cell lymphoma. ( 22338065 )
2012
34
Increased serum soluble IL-15RI+ levels in T-cell large granular lymphocyte leukemia. ( 22049515 )
2012
35
A case report: Concurrent chronic myelomonocytic leukemia and T-cell large granular lymphocytic leukemia-type clonal proliferation as detected by multiparametric flow cytometry. ( 21337493 )
2011
36
A case of concomitant T-cell large granular lymphocyte leukemia and plasma cell myeloma. ( 22252668 )
2011
37
Bone marrow failure due to T-cell large granular lymphocytic leukemia in a patient with essential thrombocythemia. ( 20934219 )
2011
38
Imatinib mesylate in T-cell large granular lymphocyte leukemia associated with chronic graft-versus-host disease. ( 21663506 )
2011
39
MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia. ( 20460636 )
2010
40
Rapid and durable molecular response of refractory T-cell large granular lymphocyte leukemia after alemtuzumab treatment. ( 20211489 )
2010
41
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. ( 19660811 )
2010
42
T-cell large granular lymphocyte leukemia: an Asian perspective. ( 20084380 )
2010
43
Long-term safety and efficacy of cyclosporin A therapy for T-cell large granular lymphocyte leukemia. ( 20038217 )
2010
44
CD20dim-positive T-cell large granular lymphocytic leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma. ( 21151394 )
2010
45
Lessons learned from an unusual presentation of CD3+, CD56- T-cell large granular lymphocyte leukemia. ( 20679608 )
2010
46
CD20-positive T-cell large granular lymphocyte leukemia: case report and review of the literature. ( 19687595 )
2009
47
T-cell large granular lymphocyte leukemia presenting as end-stage renal disease: the diagnostic role of flow-cytometric and clonality analysis of the urine sediment. ( 19203516 )
2009
48
T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases. ( 19228641 )
2009
49
T cell large granular lymphocyte leukemia associated with rheumatoid arthritis and neutropenia. ( 19394280 )
2009
50
Protein-losing enteropathy due to T-cell large granular lymphocyte leukemia. ( 19307498 )
2009

Variations for T-Cell Large Granular Lymphocyte Leukemia

Expression for T-Cell Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for T-Cell Large Granular Lymphocyte Leukemia.

Pathways for T-Cell Large Granular Lymphocyte Leukemia

Pathways related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 FASLG IL18 IL2 MICA NCAM1 STAT3
2
Show member pathways
13.17 FASLG IL18 IL2 STAT3 STAT5B
3
Show member pathways
13.04 FASLG IL18 IL2 NCAM1 STAT3 STAT5B
4 12.63 FASLG IL2 STAT3 STAT5B
5
Show member pathways
12.57 FASLG GZMB IL18 IL2 MICA
6
Show member pathways
12.42 IL18 IL2 STAT3 STAT5B
7
Show member pathways
12.41 FASLG IL18 IL2 STAT3 STAT5B
8
Show member pathways
12.38 IL18 IL2 STAT3 STAT5B
9
Show member pathways
12.36 FASLG MICA STAT3 STAT5B
10
Show member pathways
12.3 FASLG GZMB STAT3
11
Show member pathways
12.29 FASLG GZMB IL2 MICA
12
Show member pathways
12.2 IL18 IL2 STAT3 STAT5B
13
Show member pathways
12.03 FASLG STAT3 STAT5B
14
Show member pathways
11.98 IL2 STAT3 STAT5B
15 11.95 FASLG GZMB IL2 NCAM1 STAT3 STAT5B
16
Show member pathways
11.94 IL18 IL2 STAT3 STAT5B
17 11.92 NCAM1 STAT3 STAT5B
18
Show member pathways
11.88 IL2 STAT3 STAT5B
19 11.79 FASLG IL18 STAT3
20 11.71 IL2 STAT3 STAT5B
21
Show member pathways
11.5 FASLG IL2 STAT5B
22 11.41 STAT3 STAT5B
23 11.39 FASLG STAT3
24 11.38 FASLG IL2
25 11.37 STAT3 STAT5B
26
Show member pathways
11.37 FASLG GZMB IL2
27 11.36 IL18 STAT3
28 11.36 GZMB IL18 IL2 NCAM1
29 11.34 NCAM1 STAT5B
30 11.33 STAT3 STAT5B
31
Show member pathways
11.32 STAT3 STAT5B
32
Show member pathways
11.27 STAT3 STAT5B
33
Show member pathways
11.26 STAT3 STAT5B
34 11.24 STAT3 STAT5B
35
Show member pathways
11.23 STAT3 STAT5B
36 11.18 FASLG IL18
37
Show member pathways
11.08 STAT3 STAT5B
38
Show member pathways
11.07 FASLG GZMB IL18 IL2 STAT3
39 10.88 STAT3 STAT5B
40 10.88 IL18 IL2 STAT3

GO Terms for T-Cell Large Granular Lymphocyte Leukemia

Biological processes related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.81 FASLG IL2 STAT3 STAT5B
2 cell-cell signaling GO:0007267 9.79 FASLG IL18 IL2
3 MAPK cascade GO:0000165 9.76 IL18 IL2 NCAM1
4 cellular response to hormone stimulus GO:0032870 9.61 STAT3 STAT5B
5 regulation of cell adhesion GO:0030155 9.6 IL18 STAT5B
6 positive regulation of interferon-gamma production GO:0032729 9.59 IL18 IL2
7 positive regulation of erythrocyte differentiation GO:0045648 9.58 STAT3 STAT5B
8 interleukin-7-mediated signaling pathway GO:0038111 9.57 STAT3 STAT5B
9 regulation of multicellular organism growth GO:0040014 9.56 STAT3 STAT5B
10 JAK-STAT cascade GO:0007259 9.55 STAT3 STAT5B
11 cytolysis GO:0019835 9.54 GZMB MICA
12 positive regulation of inflammatory response GO:0050729 9.54 IL18 IL2 STAT5B
13 natural killer cell activation GO:0030101 9.52 IL18 IL2
14 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.49 STAT3 STAT5B
15 interleukin-15-mediated signaling pathway GO:0035723 9.48 STAT3 STAT5B
16 positive regulation of interleukin-17 production GO:0032740 9.46 IL18 IL2
17 interleukin-2-mediated signaling pathway GO:0038110 9.43 IL2 STAT5B
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 IL18 IL2 STAT3
19 positive regulation of natural killer cell proliferation GO:0032819 9.4 IL18 STAT5B
20 positive regulation of activated T cell proliferation GO:0042104 9.33 IL18 IL2 STAT5B
21 positive regulation of tissue remodeling GO:0034105 9.32 IL18 IL2
22 natural killer cell mediated cytotoxicity GO:0042267 9.13 GZMB IL18 MICA
23 cytokine-mediated signaling pathway GO:0019221 9.02 FASLG IL18 IL2 STAT3 STAT5B

Molecular functions related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 FASLG IL18 IL2
2 glucocorticoid receptor binding GO:0035259 8.62 STAT3 STAT5B

Sources for T-Cell Large Granular Lymphocyte Leukemia

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