MCID: TCL004
MIFTS: 50

T-Cell Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases, Rare diseases, Skin diseases

Aliases & Classifications for T-Cell Leukemia

MalaCards integrated aliases for T-Cell Leukemia:

Name: T-Cell Leukemia 12 15
Leukemia, T-Cell 44 73
Leukemia T-Cell 55

Classifications:



External Ids:

Disease Ontology 12 DOID:715
MeSH 44 D015458
UMLS 73 C0023492

Summaries for T-Cell Leukemia

MalaCards based summary : T-Cell Leukemia, also known as leukemia, t-cell, is related to leukemia and lymphoma. An important gene associated with T-Cell Leukemia is MIR19B2 (MicroRNA 19b-2
The authors conclude that, in addition to miR-106a, miR-20b, miR-19b-2, and miR-92-2 overexpression in tumors, their capacity to induce anchorage independence growth strongly supports an oncogenic potential for those miRNAs. they also conclude that Mylip and Rbp1-like are true targets of the miR-106-363 cluster(miR-106a, miR-18b, miR-20b, miR-19b-2, miR-92-2, and miR-363). More specifically, Rbp1-like seemed only targeted by miR-106a/miR-20b, whereas Mylip could be targeted by the four miRNAs(miR-106a, miR-20b, miR-19b-2, and miR-92-2) with miR-106a/miR-20b being more efficient.), and among its related pathways/superpathways are Parkinsons Disease Pathway and Photodynamic therapy-induced HIF-1 survival signaling. The drugs Gemcitabine and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow.

Related Diseases for T-Cell Leukemia

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to T-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 leukemia 32.6 GAS5 TAL1 TCL1A TCTA TLX1 TLX3
2 lymphoma 32.2 GAS5 TCL1A TCL1B TCL6
3 lymphoblastic leukemia 30.8 LMO1 TLX1 TLX3
4 myeloma, multiple 28.3 GAS5 MIR93 PMAIP1
5 adult t-cell leukemia 12.7
6 human t-cell leukemia virus type 1 12.5
7 human t-cell leukemia virus type 2 12.5
8 acute t cell leukemia 12.4
9 pediatric t-cell leukemia 12.3
10 human t-cell leukemia virus type 3 12.1
11 leukemia, t-cell, chronic 11.6
12 t-cell prolymphocytic leukemia 11.5
13 htlv-1 associated myelopathy/tropical spastic paraparesis 11.5
14 leukemia, acute lymphoblastic 11.5
15 myelopathy, htlv-1-associated 11.4
16 tropical spastic paraparesis 11.4
17 lymphoid leukemia 11.3
18 netherton syndrome 11.2
19 retrovirus-associated myelopathy 11.0
20 precursor t-cell acute lymphoblastic leukemia 11.0 LMO1 TAL1 TCL1A TLX1 TLX3
21 type i 10.9
22 immunodeficiency 18 10.8 LMO1 TAL1
23 hepatosplenic t-cell lymphoma 10.8
24 chronic interstitial cystitis 10.6
25 spastic paraparesis 10.5
26 spasticity 10.5
27 alcoholic hepatitis 10.5
28 follicular lymphoma 10.5
29 agammaglobulinemia 10.5
30 hematopoietic stem cell transplantation 10.4
31 hepatitis 10.2
32 endotheliitis 10.1
33 mycosis fungoides 10.1
34 human immunodeficiency virus type 1 10.1
35 pneumonia 10.1
36 peripheral t-cell lymphoma 10.1
37 scabies 10.1
38 leukemia, chronic lymphocytic 2 10.0
39 leukemia, chronic lymphocytic 10.0
40 graft-versus-host disease 10.0
41 arthritis 10.0
42 cutaneous t cell lymphoma 10.0
43 prolymphocytic leukemia 10.0
44 uveitis 10.0
45 hepatitis c 10.0
46 dermatitis 10.0
47 leukemia, b-cell, chronic 10.0
48 multiple sclerosis 10.0
49 leukemia, acute myeloid 10.0
50 hepatitis c virus 10.0

Graphical network of the top 20 diseases related to T-Cell Leukemia:



Diseases related to T-Cell Leukemia

Symptoms & Phenotypes for T-Cell Leukemia

Drugs & Therapeutics for T-Cell Leukemia

Drugs for T-Cell Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 387)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 4,Phase 2,Phase 1 95058-81-4 60750
2
Etoposide Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 33419-42-0 36462
3
Cisplatin Approved Phase 4,Phase 2,Phase 1 15663-27-1 84093 441203 2767
4
Ifosfamide Approved Phase 4,Phase 2,Phase 1 3778-73-2 3690
5
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
6
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
8
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
9
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
10
Zidovudine Approved Phase 4,Phase 2 30516-87-1 35370
11
Peginterferon alfa-2b Approved Phase 4,Phase 2 99210-65-8, 215647-85-1
12
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
13 Dexamethasone acetate Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
14
Isophosphamide mustard Phase 4,Phase 2,Phase 1 0
15 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
16 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
18 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Not Applicable
19 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
20 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Antibodies Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
27 Immunoglobulins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
28 Etoposide phosphate Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
29 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Anti-HIV Agents Phase 4,Phase 2,Phase 1,Not Applicable
32 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Anti-Retroviral Agents Phase 4,Phase 2,Phase 1,Not Applicable
34 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 BB 1101 Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Antiviral Agents Phase 4,Phase 2,Phase 1,Not Applicable
38 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 interferons Phase 4,Phase 2,Phase 1
43 Reverse Transcriptase Inhibitors Phase 4,Phase 2,Not Applicable
44 GABA Agents Phase 4,Phase 1
45 Tranquilizing Agents Phase 4,Phase 3,Not Applicable
46 Immunoglobulin G Phase 4,Phase 1,Phase 2
47 Anticonvulsants Phase 4,Phase 1
48 Interferon-alpha Phase 4,Phase 2,Phase 1
49 Psychotropic Drugs Phase 4,Phase 3,Not Applicable
50 Antimanic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 345)
# Name Status NCT ID Phase Drugs
1 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Unknown status NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
2 Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
3 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
4 Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/Lymphoma Terminated NCT00854581 Phase 4 Valproic Acid;Zidovudine
5 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
6 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
7 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
8 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
9 A Study for Aggressive Adult T-cell Leukemia-lymphoma (ATLL) Completed NCT00145002 Phase 3 VCAP-AMP-VECP with G-CSF and intrathecal prophylaxis;biweekly-CHOP with G-CSF and intrathecal prophylaxis
10 Radiation Therapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma Who Have Undergone Stem Cell Transplantation Completed NCT00031668 Phase 3
11 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
12 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
13 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
14 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
15 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
16 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
17 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
18 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
19 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
20 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
21 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
22 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
23 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
24 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
25 Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant Completed NCT01231412 Phase 3 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil;Sirolimus
26 Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult ETP-ALL Recruiting NCT03553238 Phase 2, Phase 3 Chidamide;Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-Mercaptopurine;Etoposide;Cytarabine
27 Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL Recruiting NCT03564704 Phase 2, Phase 3 Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-mercaptopurine.;Etoposide;Cytarabine;Chidamide
28 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
29 Combination Chemotherapy With or Without Etoposide in Treating Older Patients With Non-Hodgkin's Lymphoma Terminated NCT00060385 Phase 2, Phase 3 CHOP regimen;EPOCH regimen;cyclophosphamide;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
30 High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma Unknown status NCT00669812 Phase 2 carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;melphalan;methotrexate;prednisolone;vincristine sulfate
31 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
32 Combination Chemotherapy Followed by Donor Bone Marrow Transplant or Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer or Genetic Disorders Unknown status NCT00008307 Phase 2 cyclosporine;fludarabine phosphate;melphalan;methylprednisolone;mycophenolate mofetil
33 Alemtuzumab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV T-Cell Non-Hodgkin's Lymphoma Unknown status NCT00363090 Phase 1, Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
34 Vaccine Therapy and GM-CSF in Treating Patients With CNS Lymphoma Unknown status NCT00621036 Phase 2 methotrexate;thiotepa
35 Stem Cell Transplant in Treating Patients With Hematological Cancer or Other Disorders Unknown status NCT00740467 Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;mycophenolate mofetil
36 Arsenic Trioxide in Treating Patients With Recurrent or Refractory Acute Leukemia, Chronic Myeloide Leukemia, Myelodysplasia, Lymphoma, or Myeloma Unknown status NCT00003885 Phase 2 arsenic trioxide
37 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
38 Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia Unknown status NCT01976182 Phase 2 Methotrexate;Cyclophosphamide
39 KW-0761 or Investigator's Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL) Completed NCT01626664 Phase 2 Pralatrexate;gemcitabine plus oxaliplatin;DHAP
40 A Phase 2 Study of Lenalidomide in Patients With Relapsed or Recurrent Adult T-cell Leukemia-lymphoma Completed NCT01724177 Phase 2 Lenalidomide
41 Lenalidomide in HTLV-1 Adult T-Cell Leukemia Completed NCT01274533 Phase 2 Lenalidomide
42 Phase II Study of KW-0761 in Subjects With CCR4-positive Adult T-cell Leukemia-lymphoma Completed NCT00920790 Phase 2
43 Campath-1H for Treating Adult T-Cell Leukemia/Lymphoma Completed NCT00061048 Phase 2
44 Repeat-Dose of Forodesine Hydrochloride (BCX-1777) Infusion in Patients With Advanced T-Cell Leukemia Completed NCT00095381 Phase 2 forodesine hydrochloride (BCX-1777)
45 Phase II Study of the Efficacy and Toxicity of Ontak(Registered Trademark) (Denileukin Diftitox) in the Therapy of Adult T-Cell Leukemia Completed NCT00117845 Phase 2
46 A Phase II Study Of Imtox-25 In Adults With Refractory/Relapsed Cd25 Positive Adult T Cell Leukemia/Lymphoma Completed NCT01378871 Phase 2 IMTOX-25
47 Multicenter, Randomized, Open-label, Parallel-group Study to Compare mLSG15 + KW-0761 to mLSG15 Completed NCT01173887 Phase 2 VCAP/AMP/VECP(mLSG15)
48 Anti-Tac for Treatment of Leukemia Completed NCT00001941 Phase 1, Phase 2
49 EPOCH Chemotherapy and Bortezomib for Associated T-Cell Leukemia Lymphoma Completed NCT01000285 Phase 1, Phase 2 Bortezomib;Etoposide;Vincristine;Doxorubicin;Prednisone;Cyclophosphamide;Raltegravir
50 RAD001 in Relapsed or Refractory AML, ALL, CML in Blastic-Phase, Agnogenic Myeloid Metaplasia, CLL, T-Cell Leukemia, or Mantle Cell Lymphoma Completed NCT00081874 Phase 1, Phase 2 RAD001

Search NIH Clinical Center for T-Cell Leukemia

Cochrane evidence based reviews: leukemia, t-cell

Genetic Tests for T-Cell Leukemia

Anatomical Context for T-Cell Leukemia

MalaCards organs/tissues related to T-Cell Leukemia:

41
T Cells, Bone, Bone Marrow, Liver, Myeloid, Kidney, B Cells

Publications for T-Cell Leukemia

Articles related to T-Cell Leukemia:

(show top 50) (show all 2000)
# Title Authors Year
1
Successful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide. ( 29382244 )
2018
2
Indolent, waxing and waning cutaneous presentation of HTLV-1-associated adult T-cell leukemia/lymphoma in an HIV-1-positive patient. ( 29094771 )
2018
3
Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan. ( 29930027 )
2018
4
Retraction notice to Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide in adult T-cell leukemia cells. ( 29273235 )
2018
5
Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma. ( 29084771 )
2018
6
Human T-cell Leukemia Virus Type I Associated with an Increased Risk of Primary Malignant Neoplasm. ( 29755702 )
2018
7
An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia. ( 29540473 )
2018
8
NF-I_B signaling mechanisms in HTLV-1-induced adult T-cell leukemia/lymphoma. ( 29722927 )
2018
9
Mouse Models That Enhanced Our Understanding of Adult T Cell Leukemia. ( 29643841 )
2018
10
A Review of New Findings in Adult T-cell Leukemia-Lymphoma: A Focus on Current and Emerging Treatment Strategies. ( 29411267 )
2018
11
Cytotoxic T-lymphocyte-associated antigen 4-positive aggressive adult T cell leukemia/lymphoma. ( 29978285 )
2018
12
A genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients. ( 29721391 )
2018
13
Development of sugar chain-binding single chain variable fragment antibody to adult T-cell leukemia cells using glyco-nanotechnology and phage display method. ( 29351623 )
2018
14
Syngeneic hematopoietic stem cell transplantation from HTLV-1 seropositive twin for adult T-cell leukemia-lymphoma. ( 29358601 )
2018
15
Hepatic leukemia-associated macrophages exhibit a pro-inflammatory phenotype in Notch1-induced acute T cell leukemia. ( 29030004 )
2018
16
Impact of pretransplant central nervous system invasion in patients with aggressive adult T-cell leukemia lymphoma. ( 29899570 )
2018
17
Adult T-Cell Leukemia/Lymphoma With Primary Lacrimal Gland Involvement. ( 29068833 )
2018
18
Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor. ( 29212930 )
2018
19
DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma. ( 29688264 )
2018
20
Evaluation of two prognostic indices for adult T-cell leukemia/lymphoma in the subtropical endemic area, Okinawa, Japan. ( 29772611 )
2018
21
Cutaneous presentation of adult T-cell leukemia/lymphoma (ATLL). Single-center study on 37 patients in metropolitan France between 1996 and 2016. ( 29661476 )
2018
22
Targeting General Transcriptional Machinery as a Therapeutic Strategy for Adult T-Cell Leukemia. ( 29724031 )
2018
23
In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1. ( 29499169 )
2018
24
Outcomes of patients with relapsed aggressive adult T-cell leukemia-lymphoma: clinical effectiveness of anti-CCR4 antibody and allogeneic hematopoietic stem cell transplantation. ( 29371324 )
2018
25
Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. ( 29799846 )
2018
26
Role of Integrin Signaling Activation on the Development of Human T-Cell Leukemia VIrus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
27
Adult T-cell leukemia/lymphoma can be indistinguishable from other more common T-cell lymphomas. The University of Miami experience with a large cohort of cases. ( 29449683 )
2018
28
MicroRNA-3662 expression correlates with antiviral drug resistance in adult T-cell leukemia/lymphoma cells. ( 29684346 )
2018
29
EPOCH regimen as salvage therapy for adult T-cell leukemia-lymphoma. ( 29651666 )
2018
30
A case of adult T-cell leukemia/lymphoma in Korea. ( 29662869 )
2018
31
The human T-cell leukemia virus type-1 p30<sup>II</sup> protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis. ( 29462755 )
2018
32
Adult T-Cell Leukemia/Lymphoma. Review of the Literature. ( 29685460 )
2018
33
Natural Course of Human T-Cell Leukemia Virus Type 1 Proviral DNA Levels in Carriers During Pregnancy. ( 29346571 )
2018
34
Case Report: Orbital Tumor Revealing Adult T-Cell Leukemia/Lymphoma Associated with Human T-Cell Lymphotropic Virus Type-1. ( 29968553 )
2018
35
Adult T cell leukemia/lymphoma with different pathological features in each tumor site. ( 29427186 )
2018
36
Prognostic importance of pretransplant disease status for posttransplant outcomes in patients with adult T cell leukemia/lymphoma. ( 29523883 )
2018
37
Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas. ( 29148847 )
2018
38
Role of up-front allogeneic hematopoietic stem cell transplantation for patients with aggressive adult T-cell leukemia-lymphoma: a decision analysis. ( 29371687 )
2018
39
Future Perspectives on Drug Targeting in Adult T Cell Leukemia-Lymphoma. ( 29867836 )
2018
40
Fine-scale geographic clustering pattern of human T-cell leukemia virus type 1 infection among blood donors in Kyushu-Okinawa, Japan. ( 29900555 )
2018
41
Disparate effects of Shb gene deficiency on disease characteristics in murine models of myeloid, B-cell, and T-cell leukemia. ( 29792386 )
2018
42
Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia. ( 29399406 )
2018
43
Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia. ( 29077243 )
2018
44
Correction to: T cell leukemia control via Ras-Raf pathway inhibition with peptides. ( 29697701 )
2018
45
How LGL T-Cell Leukemia at 19 Gave Me Empathy for My Patients-and My Colleagues. ( 29940058 )
2018
46
Expression pattern of immunosurveillance-related antigen in adult T-cell leukemia/lymphoma. ( 29297942 )
2018
47
Diagnostic challenges of adult T-cell leukemia/lymphoma in North America - a clinical, histological, and immunophenotypic correlation with a workflow proposal. ( 29504866 )
2018
48
Critical Role of the Human T-Cell Leukemia Virus Type 1 Capsid N-Terminal Domain for Gag-Gag Interactions and Virus Particle Assembly. ( 29695435 )
2018
49
Erratum for Narulla et al., &amp;quot;Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ&amp;quot;. ( 29295960 )
2018
50
CCR4 mutations associated with superior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment. ( 29930010 )
2018

Variations for T-Cell Leukemia

Expression for T-Cell Leukemia

Search GEO for disease gene expression data for T-Cell Leukemia.

Pathways for T-Cell Leukemia

Pathways related to T-Cell Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.85 MIR106A MIR19B2 MIR20B MIR92A2
2 10.72 PMAIP1 SLC2A1
3 10.71 TLX1 TLX2 TLX3

GO Terms for T-Cell Leukemia

Cellular components related to T-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 MIR106A MIR130B MIR143 MIR19B2 MIR20B MIR92A2

Biological processes related to T-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.43 MIR143 MIR20B MIR92A2
2 cellular response to glucose starvation GO:0042149 9.32 PMAIP1 SLC2A1
3 gene silencing by miRNA GO:0035195 9.17 MIR106A MIR130B MIR143 MIR19B2 MIR20B MIR92A2
4 positive regulation of protein oligomerization GO:0032461 9.16 PMAIP1 TCL1A
5 negative regulation of cholesterol efflux GO:0090370 8.96 MIR130B MIR19B2

Molecular functions related to T-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.17 MIR106A MIR130B MIR143 MIR19B2 MIR20B MIR92A2
2 protein serine/threonine kinase activator activity GO:0043539 8.96 TCL1A TCL1B

Sources for T-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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