MCID: TBS001
MIFTS: 33

Tabes Dorsalis

Categories: Infectious diseases, Nephrological diseases, Neuronal diseases

Aliases & Classifications for Tabes Dorsalis

MalaCards integrated aliases for Tabes Dorsalis:

Name: Tabes Dorsalis 12 55 45 15 17 74
Tabes Dorsalis - Neurosyphilis 12
Posterior Spinal Sclerosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10027
ICD9CM 36 094.0
MeSH 45 D013606
NCIt 51 C35057
SNOMED-CT 69 2844004 51928006
ICD10 34 A52.11
UMLS 74 C0039223

Summaries for Tabes Dorsalis

NINDS : 55 Tabes dorsalis is a slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The degenerating nerves are in the dorsal columns of the spinal cord (the portion closest to the back of the body) and carry information that help maintain a person's sense of position. Tabes dorsalis is the result of an untreated syphilis infection. Symptoms may not appear for some decades after the initial infection and include weakness, diminished reflexes, unsteady gait, progressive degeneration of the joints, loss of coordination, episodes of intense pain and disturbed sensation, personality changes, dementia, deafness, visual impairment, and impaired response to light. The disease is more frequent in males than in females. Onset is commonly during mid-life. The incidence of tabes dorsalis is rising, in part due to co-associated HIV infection.

MalaCards based summary : Tabes Dorsalis, also known as tabes dorsalis - neurosyphilis, is related to syphilis and asymptomatic neurosyphilis. An important gene associated with Tabes Dorsalis is EXTL3 (Exostosin Like Glycosyltransferase 3), and among its related pathways/superpathways is TBC/RABGAPs. Affiliated tissues include spinal cord, brain and testes.

Disease Ontology : 12 A tertiary neurosyphilis that results in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has symptom intense, stabbing pain in the back and legs that recurs irregularly, has symptom gait ataxia, has symptom hyperesthesia, has symptom paresthesia, has symptom loss of bladder sensation leading to urine retention, has symptom erectile dysfunction.

Wikipedia : 77 Tabes dorsalis, also known as syphilitic myelopathy, is a slow degeneration (specifically,... more...

Related Diseases for Tabes Dorsalis

Diseases related to Tabes Dorsalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 syphilis 31.3 DDX41 EXTL3
2 asymptomatic neurosyphilis 30.5 CXCL13 DDX41 EXTL3
3 syphilitic myelopathy 12.4
4 neurosyphilis 12.0
5 progressive locomotor ataxia 11.6
6 syphilitic spinal sclerosis 11.6
7 3-methylglutaconic aciduria, type iii 10.4
8 joint disorders 10.4
9 arthropathy 10.4
10 paraplegia 10.4
11 late congenital syphilis 10.3 DDX41 EXTL3
12 congenital syphilis 10.3 DDX41 EXTL3
13 trigeminal neuralgia 10.3
14 ataxia and polyneuropathy, adult-onset 10.3
15 malaria 10.3
16 gastric ulcer 10.3
17 syringomyelia 10.3
18 neuropathy 10.3
19 primary syphilis 10.3 DDX41 EXTL3
20 latent syphilis 10.3 DDX41 EXTL3
21 secondary syphilis 10.3 DDX41 EXTL3
22 charcot-marie-tooth disease, axonal, type 2b 10.3 RAB7A SPTLC1
23 parenchymatous neurosyphilis 10.2 EXTL3 MBP
24 neuropathy, hereditary sensory and autonomic, type ia 10.2 NAA50 SPTLC1
25 adie pupil 10.2
26 facial spasm 10.2
27 pernicious anemia 10.2
28 cerebrotendinous xanthomatosis 10.2
29 xanthomatosis 10.2
30 human immunodeficiency virus type 1 10.2
31 immunoglobulin alpha deficiency 10.2
32 primary optic atrophy 10.2
33 diphtheria 10.2
34 duodenal ulcer 10.2
35 neuritis 10.2
36 myelitis 10.2
37 cellulitis 10.2
38 pyoderma 10.2
39 somatoform disorder 10.2
40 muscular atrophy 10.2
41 pyoderma gangrenosum 10.2
42 meningitis 10.2
43 encephalitis 10.2
44 amyloid neuropathy 10.2
45 transverse myelitis 10.2
46 hypoxia 10.2
47 autoimmune disease of peripheral nervous system 10.1 DDX41 MBP
48 brown-sequard syndrome 10.1 KANTR TCHH
49 urethral syndrome 10.1 EXTL3 KANTR
50 anus disease 10.1 EXTL3 KANTR

Comorbidity relations with Tabes Dorsalis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Diabetic Polyneuropathy Heart Disease
Neurogenic Arthropathy

Graphical network of the top 20 diseases related to Tabes Dorsalis:



Diseases related to Tabes Dorsalis

Symptoms & Phenotypes for Tabes Dorsalis

Drugs & Therapeutics for Tabes Dorsalis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Biomarker for Duchenne Disease (BioDuchenne) Recruiting NCT02994030

Search NIH Clinical Center for Tabes Dorsalis

Cochrane evidence based reviews: tabes dorsalis

Genetic Tests for Tabes Dorsalis

Anatomical Context for Tabes Dorsalis

MalaCards organs/tissues related to Tabes Dorsalis:

42
Spinal Cord, Brain, Testes, Medulla Oblongata

Publications for Tabes Dorsalis

Articles related to Tabes Dorsalis:

(show top 50) (show all 155)
# Title Authors Year
1
Édouard Manet's Tabes Dorsalis: From Painful Ataxia to Phantom Limb. ( 30336456 )
2018
2
Tabes dorsalis: Not, at all, "Elementary my dear Watson!" ( 28521659 )
2018
3
Dilated tonic pupils with tabes dorsalis in neurosyphilis as first manifestation of HIV/AIDS: a video report. ( 29545440 )
2018
4
Tabes Dorsalis and Argyll Robertson Pupils. ( 27959596 )
2016
5
Édouard Manet's Tabes Dorsalis: From Painful Ataxia to Phantom Limb. ( 27434214 )
2016
6
A clinical study of new cases of parenchymal neurosyphilis: has tabes dorsalis disappeared or been missed? ( 25321411 )
2015
7
Bilateral total knee arthroplasty for Charcot knees associated with tabes dorsalis. ( 25415801 )
2014
8
Historical review: suspension therapy for the treatment of tabes dorsalis. ( 25228352 )
2014
9
Bilateral neuro-arthropathy of the ankle as a sequela of undiagnosed tabes dorsalis. ( 23623735 )
2013
10
Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. ( 22330117 )
2011
11
Charcot's arthropathy of the hip joints: a late manifestation of tabes dorsalis successfully treated by total joint arthroplasty. report of 2 cases. ( 17689791 )
2007
12
Tibial nerve SEPs localized the lesion site in a patient with early tabes dorsalis. ( 15851744 )
2005
13
The medical Kipling--syphilis, tabes dorsalis, and Romberg's test. ( 15224672 )
2004
14
Rapidly progressive tabes dorsalis associated with selective IgA deficiency. ( 11579969 )
2001
15
The history of tabes dorsalis and the impact of observational studies in neurology. ( 10768641 )
2000
16
The suspension apparatus for tabes dorsalis. ( 10214766 )
1999
17
A new case of insufficiency fracture in a patient with tabes dorsalis. ( 9178401 )
1997
18
Neurosyphilis presenting as tabes dorsalis in a HIV carrier. ( 8334567 )
1993
19
Suspicion of somatoform disorder in undiagnosed tabes dorsalis. ( 1751873 )
1991
20
Disorders of micturition in tabes dorsalis. ( 2354317 )
1990
21
The suspension therapy for tabes dorsalis. A case history of a therapeutic fad. ( 2189379 )
1990
22
Severe lightning pain after spinal anesthesia in a patient with tabes dorsalis. ( 2764305 )
1989
23
Tabes dorsalis: electrodiagnostic features. ( 3216214 )
1988
24
Central motor and sensory conduction in adrenoleukomyeloneuropathy, cerebrotendinous xanthomatosis, HTLV-1-associated myelopathy and tabes dorsalis. ( 2851031 )
1988
25
A case of tabes dorsalis with tonic pupils and lightning pains relieved by sodium valproate. ( 3106580 )
1987
26
Amyloid neuropathy in a woman with tabes dorsalis. ( 6321985 )
1984
27
Doyle on tabes dorsalis. ( 7043000 )
1982
28
Arthur Conan Doyle's thesis on tabes dorsalis. ( 7033580 )
1982
29
Tabes dorsalis progressing to general paresis after 20 years despite routine penicillin therapy. ( 7448579 )
1980
30
Pyoderma gangrenosum, hypoplastic anaemia, tabes dorsalis. ( 1276069 )
1976
31
Tabes dorsalis: two case reports. ( 1017391 )
1976
32
'Oblongata' crises in tabes dorsalis. ( 1011037 )
1976
33
Venery, the spinal cord, and tabes dorsalis before Romberg: the contribution of Ernst Horn. ( 778342 )
1976
34
Tabes dorsalis with sudden onset of paraplegia. ( 1201461 )
1975
35
Flaccid paraplegia: a feature of spinal cord lesions in Holmes-Adie syndrome and tabes dorsalis. ( 1141918 )
1975
36
Editorial: Hazards of tabes dorsalis. ( 1203718 )
1975
37
Letter: Laplace's law, pressure neuropathy, tabes dorsalis, tic douloureux, facial spasm. ( 4479191 )
1974
38
Abnormal chemoreceptor response to hypoxia in patients with tabes dorsalis. ( 5575947 )
1971
39
Tabes dorsalis of sudden onset associated with possible transverse myelitis. ( 5430348 )
1970
40
Surgical problems associated with tabes dorsalis. ( 5220144 )
1966
41
Acute abdominal disease masked by tabes dorsalis. ( 13963862 )
1962
42
Surgical problems associated with tabes dorsalis. ( 13908042 )
1961
43
Partial remission of gastric crises in a patient with tabes dorsalis. ( 13786038 )
1961
44
Tabes dorsalis and perforated duodenal ulcer. ( 13759721 )
1961
45
Lightning pains of tabes dorsalis treated with procaine intravenously. ( 14417845 )
1959
46
Cervical arthropathy in syringomyelia, tabes dorsalis and diabetes. ( 13596464 )
1958
47
On tabes dorsalis. ( 13619929 )
1958
48
Lightning pain of tabes dorsalis treated with meticorten. ( 13566506 )
1958
49
Tabes dorsalis with special reference to primary optic atrophy. ( 13471961 )
1957
50
Lightning pains of tabes dorsalis controlled with ACTH and cortisone. ( 13232685 )
1955

Variations for Tabes Dorsalis

Expression for Tabes Dorsalis

Search GEO for disease gene expression data for Tabes Dorsalis.

Pathways for Tabes Dorsalis

Pathways related to Tabes Dorsalis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.3 RAB7A RAB7B

GO Terms for Tabes Dorsalis

Cellular components related to Tabes Dorsalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vacuolar membrane GO:0005774 8.62 RAB7A RAB7B

Biological processes related to Tabes Dorsalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome to lysosome transport GO:0008333 8.96 RAB7A RAB7B
2 phagosome-lysosome fusion GO:0090385 8.62 RAB7A RAB7B

Sources for Tabes Dorsalis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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