MCID: TBS001
MIFTS: 33

Tabes Dorsalis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Tabes Dorsalis

MalaCards integrated aliases for Tabes Dorsalis:

Name: Tabes Dorsalis 12 54 44 15 73
Tabes Dorsalis - Neurosyphilis 12
Posterior Spinal Sclerosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10027
ICD10 33 A52.11
ICD9CM 35 094.0
MeSH 44 D013606
NCIt 50 C35057
UMLS 73 C0039223

Summaries for Tabes Dorsalis

NINDS : 54 Tabes dorsalis is a slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The degenerating nerves are in the dorsal columns of the spinal cord (the portion closest to the back of the body) and carry information that help maintain a person's sense of position. Tabes dorsalis is the result of an untreated syphilis infection. Symptoms may not appear for some decades after the initial infection and include weakness, diminished reflexes, unsteady gait, progressive degeneration of the joints, loss of coordination, episodes of intense pain and disturbed sensation, personality changes, dementia, deafness, visual impairment, and impaired response to light. The disease is more frequent in males than in females. Onset is commonly during mid-life. The incidence of tabes dorsalis is rising, in part due to co-associated HIV infection.

MalaCards based summary : Tabes Dorsalis, also known as tabes dorsalis - neurosyphilis, is related to syphilis and syphilitic myelopathy, and has symptoms including intense, gait ataxia and hyperesthesia. An important gene associated with Tabes Dorsalis is EXTL3 (Exostosin Like Glycosyltransferase 3). Affiliated tissues include spinal cord, brain and testes.

Disease Ontology : 12 A tertiary neurosyphilis that results in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has symptom intense, stabbing pain in the back and legs that recurs irregularly, has symptom gait ataxia, has symptom hyperesthesia, has symptom paresthesia, has symptom loss of bladder sensation leading to urine retention, has symptom erectile dysfunction.

Wikipedia : 76 Tabes dorsalis, also known as syphilitic myelopathy, is a slow degeneration (specifically,... more...

Related Diseases for Tabes Dorsalis

Diseases related to Tabes Dorsalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 syphilis 30.4 CD79A DDX41 EXTL3
2 syphilitic myelopathy 12.2
3 neurosyphilis 11.8
4 progressive locomotor ataxia 11.4
5 syphilitic spinal sclerosis 11.4
6 late congenital syphilis 10.6 DDX41 EXTL3
7 latent syphilis 10.6 DDX41 EXTL3
8 parenchymatous neurosyphilis 10.5 EXTL3 MBP
9 charcot-marie-tooth disease, axonal, type 2b 10.4 RAB7A SPTLC1
10 apical myocardial infarction 10.4 KANTR LEFTY2
11 early yaws 10.4 CD79A EXTL3
12 trichomoniasis 10.2 CD79A EXTL3
13 chorioretinitis 10.2 CD79A EXTL3
14 3-methylglutaconic aciduria, type iii 10.2
15 arthropathy 10.2
16 paraplegia 10.2
17 urethritis 10.2 CD79A EXTL3
18 brown-sequard syndrome 10.2 KANTR TCHH
19 gastric ulcer 10.1
20 argyll robertson pupil 10.1
21 syringomyelia 10.1
22 laryngitis 10.1
23 neuropathy 10.1
24 paralytic squint 10.1 KANTR SH3BP5
25 alexia 10.1 KANTR MBP
26 endocardium disease 10.1 CD79A SH3BP5
27 oculomotor nerve paralysis 10.1 KANTR MBP
28 third cranial nerve disease 10.1 KANTR MBP
29 meningovascular neurosyphilis 10.1 CD79A MBP
30 salpingitis isthmica nodosa 10.0 CD79A KANTR
31 cicatricial entropion 10.0 CD79A KANTR
32 substernal goiter 10.0 CD79A KANTR
33 cerebral arteritis 10.0 CD79A KANTR
34 tertiary syphilis 10.0 DDX41 EXTL3 LEFTY2 SH3BP5
35 cerebellar ataxia, deafness, and narcolepsy, autosomal dominant 10.0 NAA50 SPTLC1
36 adie pupil 10.0
37 facial spasm 10.0
38 pernicious anemia 10.0
39 trigeminal neuralgia 10.0
40 cerebrotendinous xanthomatosis 10.0
41 aging 10.0
42 xanthomatosis 10.0
43 malaria 10.0
44 immunoglobulin alpha deficiency 10.0
45 primary optic atrophy 10.0
46 diphtheria 10.0
47 neuritis 10.0
48 cervicitis 10.0
49 myelitis 10.0
50 cellulitis 10.0

Comorbidity relations with Tabes Dorsalis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Diabetic Polyneuropathy Heart Disease
Neurogenic Arthropathy

Graphical network of the top 20 diseases related to Tabes Dorsalis:



Diseases related to Tabes Dorsalis

Symptoms & Phenotypes for Tabes Dorsalis

Symptoms:

12
  • intense
  • gait ataxia
  • hyperesthesia
  • paresthesia
  • loss of bladder sensation leading to urine retention
  • erectile dysfunction

Drugs & Therapeutics for Tabes Dorsalis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Biomarker for Patients With Duchenne Disease Recruiting NCT02994030

Search NIH Clinical Center for Tabes Dorsalis

Cochrane evidence based reviews: tabes dorsalis

Genetic Tests for Tabes Dorsalis

Anatomical Context for Tabes Dorsalis

MalaCards organs/tissues related to Tabes Dorsalis:

41
Spinal Cord, Brain, Testes, Bone, Medulla Oblongata

Publications for Tabes Dorsalis

Articles related to Tabes Dorsalis:

(show top 50) (show all 129)
# Title Authors Year
1
Dilated tonic pupils with tabes dorsalis in neurosyphilis as first manifestation of HIV/AIDS: a video report. ( 29545440 )
2018
2
Tabes dorsalis: Not, at all, "Elementary my dear Watson!" ( 28521659 )
2017
3
A8douard Manet's Tabes Dorsalis: From Painful Ataxia to Phantom Limb. ( 27434214 )
2016
4
Tabes Dorsalis and Argyll Robertson Pupils. ( 27959596 )
2016
5
Historical review: suspension therapy for the treatment of tabes dorsalis. ( 25228352 )
2014
6
Bilateral total knee arthroplasty for charcot knees associated with tabes dorsalis. ( 25415801 )
2014
7
A Clinical Study of New Cases of Parenchymal Neurosyphilis: Tabes Dorsalis has Disappeared or Been Missed? ( 25321411 )
2014
8
Bilateral neuro-arthropathy of the ankle as a sequela of undiagnosed tabes dorsalis. ( 23623735 )
2013
9
Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. ( 22330117 )
2011
10
Charcot's arthropathy of the hip joints: a late manifestation of tabes dorsalis successfully treated by total joint arthroplasty. report of 2 cases. ( 17689791 )
2007
11
Tibial nerve SEPs localized the lesion site in a patient with early tabes dorsalis. ( 15851744 )
2005
12
The medical Kipling--syphilis, tabes dorsalis, and Romberg's test. ( 15224672 )
2004
13
Rapidly progressive tabes dorsalis associated with selective IgA deficiency. ( 11579969 )
2001
14
The history of tabes dorsalis and the impact of observational studies in neurology. ( 10768641 )
2000
15
The suspension apparatus for tabes dorsalis. ( 10214766 )
1999
16
A new case of insufficiency fracture in a patient with tabes dorsalis. ( 9178401 )
1997
17
Neurosyphilis presenting as tabes dorsalis in a HIV carrier. ( 8334567 )
1993
18
Suspicion of somatoform disorder in undiagnosed tabes dorsalis. ( 1751873 )
1991
19
The suspension therapy for tabes dorsalis. A case history of a therapeutic fad. ( 2189379 )
1990
20
Disorders of micturition in tabes dorsalis. ( 2354317 )
1990
21
Severe lightning pain after spinal anesthesia in a patient with tabes dorsalis. ( 2764305 )
1989
22
Central motor and sensory conduction in adrenoleukomyeloneuropathy, cerebrotendinous xanthomatosis, HTLV-1-associated myelopathy and tabes dorsalis. ( 2851031 )
1988
23
Tabes dorsalis: electrodiagnostic features. ( 3216214 )
1988
24
A case of tabes dorsalis with tonic pupils and lightning pains relieved by sodium valproate. ( 3106580 )
1987
25
Amyloid neuropathy in a woman with tabes dorsalis. ( 6321985 )
1984
26
Arthur Conan Doyle's thesis on tabes dorsalis. ( 7033580 )
1982
27
Doyle on tabes dorsalis. ( 7043000 )
1982
28
Tabes dorsalis progressing to general paresis after 20 years despite routine penicillin therapy. ( 7448579 )
1980
29
'Oblongata' crises in tabes dorsalis. ( 1011037 )
1976
30
Venery, the spinal cord, and tabes dorsalis before Romberg: the contribution of Ernst Horn. ( 778342 )
1976
31
Pyoderma gangrenosum, hypoplastic anaemia, tabes dorsalis. ( 1276069 )
1976
32
Tabes dorsalis: two case reports. ( 1017391 )
1976
33
Tabes dorsalis with sudden onset of paraplegia. ( 1201461 )
1975
34
Editorial: Hazards of tabes dorsalis. ( 1203718 )
1975
35
Flaccid paraplegia: a feature of spinal cord lesions in Holmes-Adie syndrome and tabes dorsalis. ( 1141918 )
1975
36
Letter: Laplace's law, pressure neuropathy, tabes dorsalis, tic douloureux, facial spasm. ( 4479191 )
1974
37
Abnormal chemoreceptor response to hypoxia in patients with tabes dorsalis. ( 5575947 )
1971
38
Tabes dorsalis of sudden onset associated with possible transverse myelitis. ( 5430348 )
1970
39
Surgical problems associated with tabes dorsalis. ( 5220144 )
1966
40
Acute abdominal disease masked by tabes dorsalis. ( 13963862 )
1962
41
Surgical problems associated with tabes dorsalis. ( 13908042 )
1961
42
Partial remission of gastric crises in a patient with tabes dorsalis. ( 13786038 )
1961
43
Lightning pains of tabes dorsalis treated with procaine intravenously. ( 14417845 )
1959
44
Lightning pain of tabes dorsalis treated with meticorten. ( 13566506 )
1958
45
On tabes dorsalis. ( 13619929 )
1958
46
Cervical arthropathy in syringomyelia, tabes dorsalis and diabetes. ( 13596464 )
1958
47
Tabes dorsalis with special reference to primary optic atrophy. ( 13471961 )
1957
48
Lightning pains of tabes dorsalis controlled with ACTH and cortisone. ( 13232685 )
1955
49
Tabes dorsalis in the Bantu; report of a case. ( 13076672 )
1953
50
Surgical aspects of tabes dorsalis. ( 13126500 )
1953

Variations for Tabes Dorsalis

Expression for Tabes Dorsalis

Search GEO for disease gene expression data for Tabes Dorsalis.

Pathways for Tabes Dorsalis

GO Terms for Tabes Dorsalis

Sources for Tabes Dorsalis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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