MCID: TBS001
MIFTS: 35

Tabes Dorsalis

Categories: Infectious diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Tabes Dorsalis

MalaCards integrated aliases for Tabes Dorsalis:

Name: Tabes Dorsalis 12 52 53 43 15 17 71
Tabes Dorsalis - Neurosyphilis 12
Posterior Spinal Sclerosis 12
Syphilitic Myelopathy 52

Classifications:



External Ids:

Disease Ontology 12 DOID:10027
ICD9CM 34 094.0
MeSH 43 D013606
NCIt 49 C35057
SNOMED-CT 67 2844004 51928006
ICD10 32 A52.11
UMLS 71 C0039223

Summaries for Tabes Dorsalis

NINDS : 53 Tabes dorsalis is a slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The degenerating nerves are in the dorsal columns of the spinal cord (the portion closest to the back of the body) and carry information that help maintain a person's sense of position. Tabes dorsalis is the result of an untreated syphilis infection. Symptoms may not appear for some decades after the initial infection and include weakness, diminished reflexes, unsteady gait, progressive degeneration of the joints, loss of coordination, episodes of intense pain and disturbed sensation, personality changes, dementia, deafness, visual impairment, and impaired response to light. The disease is more frequent in males than in females. Onset is commonly during mid-life. The incidence of tabes dorsalis is rising, in part due to co-associated HIV infection.

MalaCards based summary : Tabes Dorsalis, also known as tabes dorsalis - neurosyphilis, is related to syphilis and asymptomatic neurosyphilis. An important gene associated with Tabes Dorsalis is CXCL13 (C-X-C Motif Chemokine Ligand 13), and among its related pathways/superpathways is Mitochondrial protein import. The drugs Teriparatide and Parathyroid hormone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and testes.

Disease Ontology : 12 A tertiary neurosyphilis that results in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has symptom intense, stabbing pain in the back and legs that recurs irregularly, has symptom gait ataxia, has symptom hyperesthesia, has symptom paresthesia, has symptom loss of bladder sensation leading to urine retention, has symptom erectile dysfunction.

Wikipedia : 74 Tabes dorsalis, is a slow degeneration (specifically, demyelination) of the neural tracts primarily in... more...

Related Diseases for Tabes Dorsalis

Diseases related to Tabes Dorsalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 syphilis 30.7 MYH9 DDX41 CD4
2 asymptomatic neurosyphilis 30.6 MYH9 CXCL13 CD4
3 syphilitic meningitis 30.5 CXCL13 CD4
4 congenital syphilis 29.8 MYH9 DDX41 CD4
5 tertiary syphilis 28.2 TTPA TCHH MYH9 DDX41 CXCL13 CD4
6 neurosyphilis 12.1
7 progressive locomotor ataxia 11.7
8 syphilitic spinal sclerosis 11.7
9 arthropathy 10.6
10 ataxia and polyneuropathy, adult-onset 10.5
11 3-methylglutaconic aciduria, type iii 10.5
12 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.5
13 paraplegia 10.4
14 syringomyelia, noncommunicating isolated 10.3
15 trigeminal neuralgia 10.3
16 cerebrotendinous xanthomatosis 10.3
17 xanthomatosis 10.3
18 malaria 10.3
19 gastric ulcer 10.3
20 syringomyelia 10.3
21 neuropathy 10.3
22 meningitis 10.3
23 aneurysm 10.3
24 adie pupil 10.2
25 facial spasm 10.2
26 immunoglobulin a deficiency 1 10.2
27 myositis 10.2
28 osteoporosis 10.2
29 pernicious anemia 10.2
30 ocular motor apraxia 10.2
31 adrenoleukodystrophy 10.2
32 meningioma, radiation-induced 10.2
33 meningioma, familial 10.2
34 intraocular pressure quantitative trait locus 10.2
35 bone mineral density quantitative trait locus 8 10.2
36 bone mineral density quantitative trait locus 15 10.2
37 deficiency anemia 10.2
38 immunoglobulin alpha deficiency 10.2
39 pain agnosia 10.2
40 spinal disease 10.2
41 primary optic atrophy 10.2
42 spinal meningioma 10.2
43 diphtheria 10.2
44 diabetic autonomic neuropathy 10.2
45 autonomic neuropathy 10.2
46 neurogenic bladder 10.2
47 polyneuropathy 10.2
48 argyll robertson pupil 10.2
49 duodenal ulcer 10.2
50 neuritis 10.2

Comorbidity relations with Tabes Dorsalis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Diabetic Polyneuropathy Heart Disease
Neurogenic Arthropathy

Graphical network of the top 20 diseases related to Tabes Dorsalis:



Diseases related to Tabes Dorsalis

Symptoms & Phenotypes for Tabes Dorsalis

Drugs & Therapeutics for Tabes Dorsalis

Drugs for Tabes Dorsalis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
2
Parathyroid hormone Approved, Investigational Phase 2 9002-64-6
3
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
4 Hormone Antagonists Phase 2
5 Hormones Phase 2
6 Calcium, Dietary Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 To Study the Efficacy of Teriparatide in Improving Remodeling of Foot Bones in Chronic Charcot Neuroarthropathy in Patients With Diabetes Mellitus. Unknown status NCT02023411 Phase 2 Teriparatide
2 Biomarker for Duchenne Disease AN INTERNATIONAL, MULTICENTER, EPIDEMIOLOGICAL PROTOCOL Recruiting NCT02994030

Search NIH Clinical Center for Tabes Dorsalis

Cochrane evidence based reviews: tabes dorsalis

Genetic Tests for Tabes Dorsalis

Anatomical Context for Tabes Dorsalis

MalaCards organs/tissues related to Tabes Dorsalis:

40
Spinal Cord, Brain, Testes, Bone, Thalamus, Medulla Oblongata

Publications for Tabes Dorsalis

Articles related to Tabes Dorsalis:

(show top 50) (show all 357)
# Title Authors PMID Year
1
Neurosyphilis in the modern era: Literature review and case series. 61
31427238 2019
2
Neurosyphilis. 61
31533185 2019
3
Neurosyphilis presenting as pure cerebellar ataxia: an atypical manifestation. 61
31473646 2019
4
Classical syphilitic lesions from the museum. 61
30083909 2019
5
Medullary involvement in neurosyphilis: a report of 12 cases and a review of the literature. 61
31632699 2019
6
Predictors of unfavorable outcome in neurosyphilis: Multicenter ID-IRI Study. 61
30368740 2019
7
Neuroborreliosis and Neurosyphilis. 61
30273247 2018
8
Charcot osteoarthropathy of the knee secondary to neurosyphilis: a rare condition managed by a challenging arthrodesis. 61
30131415 2018
9
Syphilitic meningomyelitis presenting with visceral crisis: A case report. 61
30045319 2018
10
Neurosyphilis in patients with HIV. 61
29478035 2018
11
Tabes dorsalis: Not, at all, "Elementary my dear Watson!" 61
28521659 2018
12
Dilated tonic pupils with tabes dorsalis in neurosyphilis as first manifestation of HIV/AIDS: a video report. 61
29545440 2018
13
DEVELOPMENT OF GANGLIONOPATHY AND TABETIC VISCERAL CRISES ON THE BACKGROUND OF POLYRADICULONEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY (CASE REPORT). 61
29578430 2018
14
Édouard Manet's Tabes Dorsalis: From Painful Ataxia to Phantom Limb. 61
30336456 2018
15
The big imitator strikes again: a case report of neurosyphilis in a patient with newly diagnosed HIV. 61
28220718 2017
16
Neurosyphilis in Africa: A systematic review. 61
28859081 2017
17
Subarachnoid Block-Induced Deafferentation Pain Successfully Treated with Pentazocine. 61
28978899 2017
18
[Neurosyphilis in Psychiatric Settings: Three Case Reports]. 61
28291299 2017
19
Tabes Dorsalis and Argyll Robertson Pupils. 61
27959596 2016
20
Nerve-stretching in the 19th century. 61
25697346 2016
21
Édouard Manet's Tabes Dorsalis: From Painful Ataxia to Phantom Limb. 61
27434214 2016
22
The Dercum-Muybridge Collaboration and the Study of Pathologic Gaits Using Sequential Photography. 61
26684421 2016
23
Canadian Public Health Laboratory Network laboratory guidelines for the diagnosis of neurosyphilis in Canada. 61
25798161 2015
24
Syringomyelia with Chiari I malformation presenting as hip charcot arthropathy: a case report and literature review. 61
25692057 2015
25
A clinical study of new cases of parenchymal neurosyphilis: has tabes dorsalis disappeared or been missed? 61
25321411 2015
26
Bilateral total knee arthroplasty for Charcot knees associated with tabes dorsalis. 61
25415801 2014
27
Do all Charcot Spine require surgery? 61
25257755 2014
28
Neurosyphilis in the mixed urban-rural community of the Netherlands. 61
25142195 2014
29
Erb's paraplegia with primary optic atrophy: Unusual presentation of neurosyphilis: Case report and review of literature. 61
25024583 2014
30
Moritz Heinrich Romberg (1795-1873): Early founder of neurology. 61
22711686 2014
31
Historical review: suspension therapy for the treatment of tabes dorsalis. 61
25228352 2014
32
Bilateral neuro-arthropathy of the ankle as a sequela of undiagnosed tabes dorsalis. 61
23623735 2013
33
The Dercum-Muybridge collaboration for sequential photography of neurologic disorders. 61
24145881 2013
34
Who was first to diagnose and report neuropathic arthropathy of the foot and ankle: Jean-Martin Charcot or Herbert William Page? 61
23765185 2013
35
Bilateral ulnar neuropathy at the elbow secondary to neuropathic arthropathy associated with syringomyelia. 61
23790822 2013
36
Spectrum and characterization of movement disorders secondary to neurosyphilis. 61
23395216 2013
37
Clinical spectrum of neurosyphilis among HIV-negative patients in the modern era. 61
23615173 2013
38
Wilhelm Erb's years in Leipzig (1880-1883) and their impact on the history of neurology. 61
24051758 2013
39
Charcot arthropathy of the wrist associated with cervical spondylotic myelopathy. 61
24353972 2012
40
[Jean Alfred Fournier: to 180th anniversary]. 61
23634617 2012
41
Charcot-Marie-Tooth disease presenting as a nonhealing ulcer in a 26-year-old man. 61
22371199 2012
42
Neurosyphillis presenting with normal pressure hydrocephalus in a 76 year old man. 61
23569521 2012
43
Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. 61
22330117 2011
44
Infectious myelopathies. 61
22810930 2011
45
Septic elbow in the setting of neuropathic joint as the initial presentation of a cervical syrinx. 61
21469625 2011
46
[MRI features of neurosyphilis]. 61
21440277 2011
47
"Fulfilling the chief of his duties as a physician": Harvey Cushing, selective dorsal rhizotomy and elective spine surgery for quality of life. 61
21250816 2011
48
Case report: Neuropathic arthropathy of the hip as a sequela of undiagnosed tertiary syphilis. 61
20151233 2010
49
General paresis of insane: A rarity or reality? 61
22174538 2010
50
Neuropathic arthropathy progressing with multiple joint involvement in the upper extremity due to syringomyelia and type I Arnold-Chiari malformation. 61
19547980 2010

Variations for Tabes Dorsalis

Expression for Tabes Dorsalis

Search GEO for disease gene expression data for Tabes Dorsalis.

Pathways for Tabes Dorsalis

Pathways related to Tabes Dorsalis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.42 FXN COA4

GO Terms for Tabes Dorsalis

Cellular components related to Tabes Dorsalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.02 TTPA MYH9 FXN CXCL13 CD4

Sources for Tabes Dorsalis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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