MCID: TCR004
MIFTS: 12

Tacrolimus Dose Selection

Categories: Rare diseases

Aliases & Classifications for Tacrolimus Dose Selection

MalaCards integrated aliases for Tacrolimus Dose Selection:

Name: Tacrolimus Dose Selection 59

Classifications:



External Ids:

Orphanet 59 ORPHA241043

Summaries for Tacrolimus Dose Selection

MalaCards based summary : Tacrolimus Dose Selection is related to clopidogrel resistance. An important gene associated with Tacrolimus Dose Selection is CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4), and among its related pathways/superpathways are Drug metabolism - cytochrome P450 and Statin Pathway - Generalized, Pharmacokinetics.

Related Diseases for Tacrolimus Dose Selection

Diseases related to Tacrolimus Dose Selection via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 clopidogrel resistance 9.2 CYP3A5 CYP3A4

Symptoms & Phenotypes for Tacrolimus Dose Selection

Drugs & Therapeutics for Tacrolimus Dose Selection

Search Clinical Trials , NIH Clinical Center for Tacrolimus Dose Selection

Genetic Tests for Tacrolimus Dose Selection

Anatomical Context for Tacrolimus Dose Selection

Publications for Tacrolimus Dose Selection

Articles related to Tacrolimus Dose Selection:

# Title Authors PMID Year
1
Role of pharmacogenomics in dialysis and transplantation. 38
25162201 2014

Variations for Tacrolimus Dose Selection

Expression for Tacrolimus Dose Selection

Search GEO for disease gene expression data for Tacrolimus Dose Selection.

Pathways for Tacrolimus Dose Selection

Pathways related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.25 CYP3A5 CYP3A4
2
Show member pathways
11.57 CYP3A5 CYP3A4
3
Show member pathways
11.31 CYP3A5 CYP3A4
4
Show member pathways
11.28 CYP3A5 CYP3A4
5
Show member pathways
11.19 CYP3A5 CYP3A4
6 11.14 CYP3A5 CYP3A4
7
Show member pathways
11 CYP3A5 CYP3A4
8 10.87 CYP3A5 CYP3A4
9
Show member pathways
10.87 CYP3A5 CYP3A4
10 10.62 CYP3A5 CYP3A4
11 10.33 CYP3A5 CYP3A4
12 10.13 CYP3A5 CYP3A4
13 9.62 CYP3A5 CYP3A4

GO Terms for Tacrolimus Dose Selection

Cellular components related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 8.96 CYP3A5 CYP3A4
2 organelle membrane GO:0031090 8.62 CYP3A5 CYP3A4

Biological processes related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.4 CYP3A5 CYP3A4
2 steroid metabolic process GO:0008202 9.37 CYP3A5 CYP3A4
3 xenobiotic metabolic process GO:0006805 9.32 CYP3A5 CYP3A4
4 oxidative demethylation GO:0070989 9.26 CYP3A5 CYP3A4
5 lipid hydroxylation GO:0002933 9.16 CYP3A5 CYP3A4
6 drug catabolic process GO:0042737 8.96 CYP3A5 CYP3A4
7 alkaloid catabolic process GO:0009822 8.62 CYP3A5 CYP3A4

Molecular functions related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.43 CYP3A5 CYP3A4
2 iron ion binding GO:0005506 9.4 CYP3A5 CYP3A4
3 heme binding GO:0020037 9.37 CYP3A5 CYP3A4
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.32 CYP3A5 CYP3A4
5 monooxygenase activity GO:0004497 9.26 CYP3A5 CYP3A4
6 oxygen binding GO:0019825 9.16 CYP3A5 CYP3A4
7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 8.96 CYP3A5 CYP3A4
8 estrogen 16-alpha-hydroxylase activity GO:0101020 8.62 CYP3A5 CYP3A4

Sources for Tacrolimus Dose Selection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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