Tacrolimus Dose Selection disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Tacrolimus Dose Selection

MalaCards integrated aliases for Tacrolimus Dose Selection:

Name: Tacrolimus Dose Selection ⁶⁰

Classifications:

MalaCards categories:
Global: Rare diseases

See all MalaCards categories (disease lists)

External Ids:

Orphanet ⁶⁰ ORPHA241043

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Summaries for Tacrolimus Dose Selection

MalaCards based summary : Tacrolimus Dose Selection is related to clopidogrel resistance. Among its related pathways/superpathways are Drug metabolism - cytochrome P450 and Statin Pathway - Generalized, Pharmacokinetics.

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Related Diseases for Tacrolimus Dose Selection

Diseases related to Tacrolimus Dose Selection via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	clopidogrel resistance	9.5	CYP3A4 CYP3A5

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Symptoms & Phenotypes for Tacrolimus Dose Selection

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Drugs & Therapeutics for Tacrolimus Dose Selection

Search Clinical Trials , NIH Clinical Center for Tacrolimus Dose Selection

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Genetic Tests for Tacrolimus Dose Selection

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Anatomical Context for Tacrolimus Dose Selection

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Publications for Tacrolimus Dose Selection

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Genes for Tacrolimus Dose Selection

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Variations for Tacrolimus Dose Selection

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Expression for Tacrolimus Dose Selection

Search GEO for disease gene expression data for Tacrolimus Dose Selection.

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Pathways for Tacrolimus Dose Selection

Pathways related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Drug metabolism - cytochrome P450 ³⁸ Show member pathways Aflatoxin B1 metabolism ¹ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶² Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²³ Benzodiazepine Pathway, Pharmacokinetics ⁶² Celecoxib Pathway, Pharmacokinetics ⁶² Chemical carcinogenesis ³⁸ Drug metabolism - other enzymes ³⁸ Fluvoxamine Pathway, Pharmacokinetics ⁶² Haloperidol Pathway, Pharmacokinetics ⁶² Ifosfamide Pathway, Pharmacokinetics ⁶² Metabolism of xenobiotics by cytochrome P450 ³⁸ Naproxen Pathway, Pharmacokinetics ⁶² Nicotine Metabolism ¹ Nicotine Pathway, Pharmacokinetics ⁶² Oxycodone Pathway, Pharmacokinetics ⁶² Retinol metabolism ³⁸ Retinol metabolism ²³ Sertraline Pathway, Pharmacokinetics ⁶² Voriconazole Pathway, Pharmacokinetics ⁶²	12.29	CYP3A4 CYP3A5
2	Statin Pathway - Generalized, Pharmacokinetics ⁶² Show member pathways Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics ⁶² Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics ⁶² Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics ⁶² Clobazam Pathway, Pharmacokinetics ⁶² Diclofenac Metabolic Pathway ¹ Diclofenac Pathway, Pharmacokinetics ⁶² Fluvastatin Pathway, Pharmacokinetics ⁶² Ibuprofen Pathway, Pharmacokinetics ⁶² Pravastatin Pathway, Pharmacokinetics ⁶² Rosiglitazone Pathway, Pharmacokinetics ⁶² Rosuvastatin Pathway, Pharmacokinetics ⁶²	11.61	CYP3A4 CYP3A5
3	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶² Show member pathways Clozapine Pathway, Pharmacokinetics ⁶² Doxepin Pathway, Pharmacokinetics ⁶² Fluoxetine Pathway, Pharmacokinetics ⁶² Gefitinib Pathway, Pharmacokinetics ⁶² Nevirapine Pathway, Pharmacokinetics ⁶² Pazopanib Pathway, Pharmacokinetics ⁶² Warfarin Pathway, Pharmacokinetics ⁶²	11.43	CYP3A4 CYP3A5
4	Paroxetine Pathway, Pharmacokinetics ⁶² Show member pathways Amitriptyline and Nortriptyline Pathway, Pharmacokinetics ⁶² Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ⁶⁷ Citalopram Pathway, Pharmacokinetics ⁶² Clomipramine Pathway, Pharmacokinetics ⁶² Clopidogrel Pathway, Pharmacokinetics ⁶² Imipramine/Desipramine Pathway, Pharmacokinetics ⁶² Lidocaine metabolism ¹ Olanzapine Pathway, Pharmacokinetics ⁶² Proton Pump Inhibitor Pathway, Pharmacokinetics ⁶² Venlafaxine Pathway, Pharmacokinetics ⁶² Verapamil Pathway, Pharmacokinetics ⁶²	11.39	CYP3A4 CYP3A5
5	Steroid hormone biosynthesis ³⁸ Show member pathways allopregnanolone biosynthesis ¹	11.34	CYP3A4 CYP3A5
6	Phenytoin Pathway, Pharmacokinetics ⁶² Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶² Carbamazepine Pathway, Pharmacokinetics ⁶² Cyclophosphamide Pathway, Pharmacokinetics ⁶² Efavirenz Pathway, Pharmacokinetics ⁶² Sorafenib Pharmacokinetics ⁶²	11.32	CYP3A4 CYP3A5
7	Androstenedione and testosterone biosynthesis and metabolism p.1 ²³ Show member pathways Estrogen biosynthesis ²³ Estrone metabolism ²³ Steroid Biosynthesis ¹	11.23	CYP3A4 CYP3A5
8	Irinotecan Pathway ¹ Show member pathways APC truncation mutants are not K63 polyubiquitinated ⁶⁷ Irinotecan Pathway, Pharmacodynamics ⁶² Irinotecan Pathway, Pharmacokinetics ⁶² Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics ⁶²	11.23	CYP3A4 CYP3A5
9	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶²	11.16	CYP3A4 CYP3A5
10	Tamoxifen metabolism ¹ Show member pathways Tamoxifen Pathway, Pharmacokinetics ⁶²	11.02	CYP3A4 CYP3A5
11	Constitutive Androstane Receptor Pathway ¹	10.91	CYP3A4 CYP3A5
12	Erlotinib Pathway, Pharmacokinetics ⁶² Show member pathways Atazanavir Pathway, Pharmacokinetics/Pharmacodynamics ⁶² Dasatinib Pathway, Pharmacokinetics ⁶²	10.75	CYP3A4 CYP3A5
13	Aflatoxin activation and detoxification ⁶⁷	10.68	CYP3A4 CYP3A5
14	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics ⁶²	10.43	CYP3A4 CYP3A5
15	Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics ⁶²	10.33	CYP3A4 CYP3A5
16	Taxane Pathway, Pharmacokinetics ⁶²	10.07	CYP3A4 CYP3A5
17	Vinka Alkaloid Pathway, Pharmacokinetics ⁶²	9.62	CYP3A4 CYP3A5

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GO Terms for Tacrolimus Dose Selection

Cellular components related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intracellular membrane-bounded organelle	GO:0043231	8.96	CYP3A4 CYP3A5
2	organelle membrane	GO:0031090	8.62	CYP3A4 CYP3A5

Biological processes related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	9.4	CYP3A4 CYP3A5
2	steroid metabolic process	GO:0008202	9.37	CYP3A4 CYP3A5
3	xenobiotic metabolic process	GO:0006805	9.32	CYP3A4 CYP3A5
4	oxidative demethylation	GO:0070989	9.26	CYP3A4 CYP3A5
5	drug catabolic process	GO:0042737	9.16	CYP3A4 CYP3A5
6	lipid hydroxylation	GO:0002933	8.96	CYP3A4 CYP3A5
7	alkaloid catabolic process	GO:0009822	8.62	CYP3A4 CYP3A5

Molecular functions related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.43	CYP3A4 CYP3A5
2	heme binding	GO:0020037	9.4	CYP3A4 CYP3A5
3	iron ion binding	GO:0005506	9.37	CYP3A4 CYP3A5
4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	9.32	CYP3A4 CYP3A5
5	monooxygenase activity	GO:0004497	9.26	CYP3A4 CYP3A5
6	oxygen binding	GO:0019825	9.16	CYP3A4 CYP3A5
7	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO:0016712	8.96	CYP3A4 CYP3A5
8	estrogen 16-alpha-hydroxylase activity	GO:0101020	8.62	CYP3A4 CYP3A5

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Sources for Tacrolimus Dose Selection

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

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³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

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⁴⁵ MeSH

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⁴⁷ MGI

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⁴⁹ NCBI Bookshelf

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⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

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⁶⁷ Reactome

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⁶⁹ SNOMED-CT

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⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia