Tacrolimus Dose Selection disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Tacrolimus Dose Selection

MalaCards integrated aliases for Tacrolimus Dose Selection:

Name: Tacrolimus Dose Selection ⁵⁹

Classifications:

MalaCards categories:
Global: Rare diseases

See all MalaCards categories (disease lists)

External Ids:

Orphanet ⁵⁹ ORPHA241043

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Summaries for Tacrolimus Dose Selection

MalaCards based summary : Tacrolimus Dose Selection is related to clopidogrel resistance. An important gene associated with Tacrolimus Dose Selection is CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4), and among its related pathways/superpathways are Drug metabolism - cytochrome P450 and Statin Pathway - Generalized, Pharmacokinetics.

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Related Diseases for Tacrolimus Dose Selection

Diseases related to Tacrolimus Dose Selection via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	clopidogrel resistance	9.2	CYP3A5 CYP3A4

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Symptoms & Phenotypes for Tacrolimus Dose Selection

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Drugs & Therapeutics for Tacrolimus Dose Selection

Search Clinical Trials , NIH Clinical Center for Tacrolimus Dose Selection

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Genetic Tests for Tacrolimus Dose Selection

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Anatomical Context for Tacrolimus Dose Selection

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Publications for Tacrolimus Dose Selection

Articles related to Tacrolimus Dose Selection:

#	Title	Authors	PMID	Year
1	Role of pharmacogenomics in dialysis and transplantation. ³⁸	Birdwell K	25162201	2014

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Genes for Tacrolimus Dose Selection

Genes related to Tacrolimus Dose Selection (2 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	25	Orphanet ⁵⁹
2	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	25	Orphanet ⁵⁹

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Variations for Tacrolimus Dose Selection

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Expression for Tacrolimus Dose Selection

Search GEO for disease gene expression data for Tacrolimus Dose Selection.

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Pathways for Tacrolimus Dose Selection

Pathways related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	Drug metabolism - cytochrome P450 ³⁷ Show member pathways Aflatoxin B1 metabolism ¹ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶¹ Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶¹ Celecoxib Pathway, Pharmacokinetics ⁶¹ Chemical carcinogenesis ³⁷ Drug metabolism - other enzymes ³⁷ Fluoxetine Pathway, Pharmacokinetics ⁶¹ Fluvoxamine Pathway, Pharmacokinetics ⁶¹ Haloperidol Pathway, Pharmacokinetics ⁶¹ Ifosfamide Pathway, Pharmacokinetics ⁶¹ Metabolism of xenobiotics by cytochrome P450 ³⁷ Naproxen Pathway, Pharmacokinetics ⁶¹ Nicotine Metabolism ¹ Nicotine Pathway, Pharmacokinetics ⁶¹ Retinol metabolism ³⁷ Retinol metabolism ²² Sertraline Pathway, Pharmacokinetics ⁶¹ Voriconazole Pathway, Pharmacokinetics ⁶¹	12.25	CYP3A5 CYP3A4
2	Statin Pathway - Generalized, Pharmacokinetics ⁶¹ Show member pathways Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics ⁶¹ Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics ⁶¹ Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics ⁶¹ Clobazam Pathway, Pharmacokinetics ⁶¹ Diclofenac Metabolic Pathway ¹ Diclofenac Pathway, Pharmacokinetics ⁶¹ Fluvastatin Pathway, Pharmacokinetics ⁶¹ Ibuprofen Pathway, Pharmacokinetics ⁶¹ Pravastatin Pathway, Pharmacokinetics ⁶¹ Rosiglitazone Pathway, Pharmacokinetics ⁶¹ Rosuvastatin Pathway, Pharmacokinetics ⁶¹	11.57	CYP3A5 CYP3A4
3	Steroid hormone biosynthesis ³⁷ Show member pathways allopregnanolone biosynthesis ¹	11.31	CYP3A5 CYP3A4
4	Phenytoin Pathway, Pharmacokinetics ⁶¹ Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶¹ Carbamazepine Pathway, Pharmacokinetics ⁶¹ Cyclophosphamide Pathway, Pharmacokinetics ⁶¹ Efavirenz Pathway, Pharmacokinetics ⁶¹ Sorafenib Pharmacokinetics ⁶¹	11.28	CYP3A5 CYP3A4
5	Androstenedione and testosterone biosynthesis and metabolism p.1 ²² Show member pathways Estrogen biosynthesis ²² Estrone metabolism ²² Steroid Biosynthesis ¹	11.19	CYP3A5 CYP3A4
6	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶¹	11.14	CYP3A5 CYP3A4
7	Tamoxifen metabolism ¹ Show member pathways Tamoxifen Pathway, Pharmacokinetics ⁶¹	11	CYP3A5 CYP3A4
8	Constitutive Androstane Receptor Pathway ¹	10.87	CYP3A5 CYP3A4
9	Erlotinib Pathway, Pharmacokinetics ⁶¹ Show member pathways Atazanavir Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Dasatinib Pathway, Pharmacokinetics ⁶¹ Gefitinib Pathway, Pharmacokinetics ⁶¹	10.87	CYP3A5 CYP3A4
10	Aflatoxin activation and detoxification ⁶⁶	10.62	CYP3A5 CYP3A4
11	Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.33	CYP3A5 CYP3A4
12	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.13	CYP3A5 CYP3A4
13	Vinka Alkaloid Pathway, Pharmacokinetics ⁶¹	9.62	CYP3A5 CYP3A4

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GO Terms for Tacrolimus Dose Selection

Cellular components related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intracellular membrane-bounded organelle	GO:0043231	8.96	CYP3A5 CYP3A4
2	organelle membrane	GO:0031090	8.62	CYP3A5 CYP3A4

Biological processes related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	9.4	CYP3A5 CYP3A4
2	steroid metabolic process	GO:0008202	9.37	CYP3A5 CYP3A4
3	xenobiotic metabolic process	GO:0006805	9.32	CYP3A5 CYP3A4
4	oxidative demethylation	GO:0070989	9.26	CYP3A5 CYP3A4
5	lipid hydroxylation	GO:0002933	9.16	CYP3A5 CYP3A4
6	drug catabolic process	GO:0042737	8.96	CYP3A5 CYP3A4
7	alkaloid catabolic process	GO:0009822	8.62	CYP3A5 CYP3A4

Molecular functions related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.43	CYP3A5 CYP3A4
2	iron ion binding	GO:0005506	9.4	CYP3A5 CYP3A4
3	heme binding	GO:0020037	9.37	CYP3A5 CYP3A4
4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	9.32	CYP3A5 CYP3A4
5	monooxygenase activity	GO:0004497	9.26	CYP3A5 CYP3A4
6	oxygen binding	GO:0019825	9.16	CYP3A5 CYP3A4
7	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO:0016712	8.96	CYP3A5 CYP3A4
8	estrogen 16-alpha-hydroxylase activity	GO:0101020	8.62	CYP3A5 CYP3A4

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Sources for Tacrolimus Dose Selection

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