Tacrolimus Dose Selection disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Tacrolimus Dose Selection

MalaCards integrated aliases for Tacrolimus Dose Selection:

Name: Tacrolimus Dose Selection ⁵⁹

Classifications:

MalaCards categories:
Global: Rare diseases

See all MalaCards categories (disease lists)

External Ids:

Orphanet ⁵⁹ ORPHA241043

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Summaries for Tacrolimus Dose Selection

MalaCards based summary : Tacrolimus Dose Selection is related to clopidogrel resistance. Among its related pathways/superpathways are Drug metabolism - cytochrome P450 and Statin Pathway - Generalized, Pharmacokinetics.

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Related Diseases for Tacrolimus Dose Selection

Diseases related to Tacrolimus Dose Selection via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	clopidogrel resistance	9.0	CYP3A4 CYP3A5

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Symptoms & Phenotypes for Tacrolimus Dose Selection

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Drugs & Therapeutics for Tacrolimus Dose Selection

Search Clinical Trials , NIH Clinical Center for Tacrolimus Dose Selection

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Genetic Tests for Tacrolimus Dose Selection

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Anatomical Context for Tacrolimus Dose Selection

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Publications for Tacrolimus Dose Selection

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Genes for Tacrolimus Dose Selection

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Variations for Tacrolimus Dose Selection

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Expression for Tacrolimus Dose Selection

Search GEO for disease gene expression data for Tacrolimus Dose Selection.

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Pathways for Tacrolimus Dose Selection

Pathways related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Drug metabolism - cytochrome P450 ³⁷ Show member pathways Aflatoxin B1 metabolism ¹ Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶¹ Celecoxib Pathway, Pharmacokinetics ⁶¹ Chemical carcinogenesis ³⁷ Drug metabolism - other enzymes ³⁷ Fluvoxamine Pathway, Pharmacokinetics ⁶¹ Haloperidol Pathway, Pharmacokinetics ⁶¹ Ifosfamide Pathway, Pharmacokinetics ⁶¹ Metabolism of xenobiotics by cytochrome P450 ³⁷ Naproxen Pathway, Pharmacokinetics ⁶¹ Oxycodone Pathway, Pharmacokinetics ⁶¹ Retinol metabolism ³⁷ Retinol metabolism ²² Voriconazole Pathway, Pharmacokinetics ⁶¹	12.27	CYP3A4 CYP3A5
2	Statin Pathway - Generalized, Pharmacokinetics ⁶¹ Show member pathways Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics ⁶¹ Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics ⁶¹ Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics ⁶¹ Fluvastatin Pathway, Pharmacokinetics ⁶¹ Ibuprofen Pathway, Pharmacokinetics ⁶¹ Pravastatin Pathway, Pharmacokinetics ⁶¹ Rosiglitazone Pathway, Pharmacokinetics ⁶¹ Rosuvastatin Pathway, Pharmacokinetics ⁶¹	11.5	CYP3A4 CYP3A5
3	Imipramine/Desipramine Pathway, Pharmacokinetics ⁶¹ Show member pathways Amitriptyline and Nortriptyline Pathway, Pharmacokinetics ⁶¹ Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ⁶⁶ Citalopram Pathway, Pharmacokinetics ⁶¹ Clomipramine Pathway, Pharmacokinetics ⁶¹ Clopidogrel Pathway, Pharmacokinetics ⁶¹ Clozapine Pathway, Pharmacokinetics ⁶¹ Colchicine Metabolic Pathway ¹ Lidocaine metabolism ¹ Olanzapine Pathway, Pharmacokinetics ⁶¹ Paroxetine Pathway, Pharmacokinetics ⁶¹ Proton Pump Inhibitor Pathway, Pharmacokinetics ⁶¹ Venlafaxine Pathway, Pharmacokinetics ⁶¹ Verapamil Pathway, Pharmacokinetics ⁶¹	11.46	CYP3A4 CYP3A5
4	Steroid hormone biosynthesis ³⁷ Show member pathways allopregnanolone biosynthesis ¹	11.36	CYP3A4 CYP3A5
5	Gefitinib Pathway, Pharmacokinetics ⁶¹ Show member pathways Doxepin Pathway, Pharmacokinetics ⁶¹ Fluoxetine Pathway, Pharmacokinetics ⁶¹ Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Nevirapine Pathway, Pharmacokinetics ⁶¹ Pazopanib Pathway, Pharmacokinetics ⁶¹ Warfarin Pathway, Pharmacokinetics ⁶¹	11.33	CYP3A4 CYP3A5
6	Tamoxifen Pathway, Pharmacokinetics ⁶¹ Show member pathways Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶¹ Efavirenz Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Tamoxifen metabolism ¹	11.31	CYP3A4 CYP3A5
7	Phenytoin Pathway, Pharmacokinetics ⁶¹ Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶¹ Carbamazepine Pathway, Pharmacokinetics ⁶¹ Cyclophosphamide Pathway, Pharmacokinetics ⁶¹ Sorafenib Pharmacokinetics ⁶¹	11.26	CYP3A4 CYP3A5
8	Irinotecan Pathway ¹ Show member pathways Irinotecan Pathway, Pharmacodynamics ⁶¹ Irinotecan Pathway, Pharmacokinetics ⁶¹ Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	11.24	CYP3A4 CYP3A5
9	Androstenedione and testosterone biosynthesis and metabolism p.1 ²² Show member pathways Estrogen biosynthesis ²² Estrone metabolism ²² Steroid Biosynthesis ¹	11.21	CYP3A4 CYP3A5
10	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶¹	11.16	CYP3A4 CYP3A5
11	Codeine and Morphine Pathway, Pharmacokinetics ⁶¹ Show member pathways Codeine and Morphine Metabolism ¹ Ivacaftor pathway, pharmacokinetics/pharmacodynamics ⁶¹ Macrolide Antibiotic Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Tacrolimus/Cyclosporine Pathway, Pharmacokinetics ⁶¹ Tramadol Pharmacokinetics ⁶¹	11.01	CYP3A4 CYP3A5
12	Constitutive Androstane Receptor Pathway ¹	10.91	CYP3A4 CYP3A5
13	Erlotinib Pathway, Pharmacokinetics ⁶¹ Show member pathways Atazanavir Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Dasatinib Pathway, Pharmacokinetics ⁶¹	10.75	CYP3A4 CYP3A5
14	Aflatoxin activation and detoxification ⁶⁶	10.68	CYP3A4 CYP3A5
15	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.43	CYP3A4 CYP3A5
16	Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.33	CYP3A4 CYP3A5
17	Taxane Pathway, Pharmacokinetics ⁶¹	10.07	CYP3A4 CYP3A5
18	Vinka Alkaloid Pathway, Pharmacokinetics ⁶¹	9.62	CYP3A4 CYP3A5

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GO Terms for Tacrolimus Dose Selection

Cellular components related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	organelle membrane	GO:0031090	8.62	CYP3A4 CYP3A5

Biological processes related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	9.4	CYP3A4 CYP3A5
2	steroid metabolic process	GO:0008202	9.37	CYP3A4 CYP3A5
3	xenobiotic metabolic process	GO:0006805	9.32	CYP3A4 CYP3A5
4	oxidative demethylation	GO:0070989	9.26	CYP3A4 CYP3A5
5	drug catabolic process	GO:0042737	9.16	CYP3A4 CYP3A5
6	lipid hydroxylation	GO:0002933	8.96	CYP3A4 CYP3A5
7	alkaloid catabolic process	GO:0009822	8.62	CYP3A4 CYP3A5

Molecular functions related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.43	CYP3A4 CYP3A5
2	iron ion binding	GO:0005506	9.4	CYP3A4 CYP3A5
3	heme binding	GO:0020037	9.37	CYP3A4 CYP3A5
4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	9.32	CYP3A4 CYP3A5
5	monooxygenase activity	GO:0004497	9.26	CYP3A4 CYP3A5
6	oxygen binding	GO:0019825	9.16	CYP3A4 CYP3A5
7	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO:0016712	8.96	CYP3A4 CYP3A5
8	estrogen 16-alpha-hydroxylase activity	GO:0101020	8.62	CYP3A4 CYP3A5

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Sources for Tacrolimus Dose Selection

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

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²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

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³² HPO

³³ ICD10

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³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁶ MGI

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⁴⁸ NCBI Bookshelf

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⁵² NIH Clinical Center

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⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁸ SNOMED-CT

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⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia