Tacrolimus Dose Selection disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Tacrolimus Dose Selection

MalaCards integrated aliases for Tacrolimus Dose Selection:

Name: Tacrolimus Dose Selection ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases

See all MalaCards categories (disease lists)

External Ids:

Orphanet ⁵⁸ ORPHA241043

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Summaries for Tacrolimus Dose Selection

MalaCards based summary : Tacrolimus Dose Selection is related to clopidogrel resistance and proctitis. An important gene associated with Tacrolimus Dose Selection is CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4), and among its related pathways/superpathways are Drug metabolism - cytochrome P450 and Statin Pathway - Generalized, Pharmacokinetics.

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Related Diseases for Tacrolimus Dose Selection

Diseases related to Tacrolimus Dose Selection via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	clopidogrel resistance	9.5	CYP3A5 CYP3A4
2	proctitis	9.4	CYP3A5 CYP3A4
3	neutropenia	9.2	CYP3A5 CYP3A4

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Symptoms & Phenotypes for Tacrolimus Dose Selection

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Drugs & Therapeutics for Tacrolimus Dose Selection

Search Clinical Trials , NIH Clinical Center for Tacrolimus Dose Selection

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Genetic Tests for Tacrolimus Dose Selection

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Anatomical Context for Tacrolimus Dose Selection

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Publications for Tacrolimus Dose Selection

Articles related to Tacrolimus Dose Selection:

#	Title	Authors	PMID	Year
1	Role of pharmacogenomics in dialysis and transplantation. ⁶¹	Birdwell K	25162201	2014

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Genes for Tacrolimus Dose Selection

Genes related to Tacrolimus Dose Selection (2 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	25	Orphanet ⁵⁸
2	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	25	Orphanet ⁵⁸

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Variations for Tacrolimus Dose Selection

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Expression for Tacrolimus Dose Selection

Search GEO for disease gene expression data for Tacrolimus Dose Selection.

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Pathways for Tacrolimus Dose Selection

Pathways related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Drug metabolism - cytochrome P450 ³⁶ Show member pathways Aflatoxin B1 metabolism ¹ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶⁰ Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶⁰ Celecoxib Pathway, Pharmacokinetics ⁶⁰ Chemical carcinogenesis ³⁶ Drug metabolism - other enzymes ³⁶ Fluoxetine Pathway, Pharmacokinetics ⁶⁰ Fluvoxamine Pathway, Pharmacokinetics ⁶⁰ Haloperidol Pathway, Pharmacokinetics ⁶⁰ Ifosfamide Pathway, Pharmacokinetics ⁶⁰ Metabolism of xenobiotics by cytochrome P450 ³⁶ Naproxen Pathway, Pharmacokinetics ⁶⁰ Nicotine Metabolism ¹ Nicotine Pathway, Pharmacokinetics ⁶⁰ Retinol metabolism ²² Retinol metabolism ³⁶ Sertraline Pathway, Pharmacokinetics ⁶⁰ Voriconazole Pathway, Pharmacokinetics ⁶⁰	12.31	CYP3A5 CYP3A4
2	Statin Pathway - Generalized, Pharmacokinetics ⁶⁰ Show member pathways Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics ⁶⁰ Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics ⁶⁰ Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics ⁶⁰ Clobazam Pathway, Pharmacokinetics ⁶⁰ Diclofenac Metabolic Pathway ¹ Diclofenac Pathway, Pharmacokinetics ⁶⁰ Fluvastatin Pathway, Pharmacokinetics ⁶⁰ Ibuprofen Pathway, Pharmacokinetics ⁶⁰ Pravastatin Pathway, Pharmacokinetics ⁶⁰ Rosiglitazone Pathway, Pharmacokinetics ⁶⁰ Rosuvastatin Pathway, Pharmacokinetics ⁶⁰	11.63	CYP3A5 CYP3A4
3	Imipramine/Desipramine Pathway, Pharmacokinetics ⁶⁰ Show member pathways Amitriptyline and Nortriptyline Pathway, Pharmacokinetics ⁶⁰ Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ⁶⁵ Candesartan Pathway, Pharmacokinetics ⁶⁰ Citalopram Pathway, Pharmacokinetics ⁶⁰ Clomipramine Pathway, Pharmacokinetics ⁶⁰ Clozapine Pathway, Pharmacokinetics ⁶⁰ Doxepin Pathway, Pharmacokinetics ⁶⁰ Lidocaine metabolism ¹ Metoprolol Pathway, Pharmacokinetics ⁶⁰ Nevirapine Pathway, Pharmacokinetics ⁶⁰ Olanzapine Pathway, Pharmacokinetics ⁶⁰ Paroxetine Pathway, Pharmacokinetics ⁶⁰ Proton Pump Inhibitor Pathway, Pharmacokinetics ⁶⁰ Venlafaxine Pathway, Pharmacokinetics ⁶⁰ Verapamil Pathway, Pharmacokinetics ⁶⁰ Warfarin Pathway, Pharmacokinetics ⁶⁰	11.58	CYP3A5 CYP3A4
4	Carvedilol Pathway, Pharmacokinetics ⁶⁰ Show member pathways Clopidogrel Pathway, Pharmacokinetics ⁶⁰ Codeine and Morphine Metabolism ¹ Codeine and Morphine Pathway, Pharmacokinetics ⁶⁰ Ivacaftor pathway, pharmacokinetics/pharmacodynamics ⁶⁰ Losartan Pathway, Pharmacokinetics ⁶⁰ Macrolide Antibiotic Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Oxycodone Pathway, Pharmacokinetics ⁶⁰ Tacrolimus/Cyclosporine Pathway, Pharmacokinetics ⁶⁰ Tramadol Pharmacokinetics ⁶⁰	11.43	CYP3A5 CYP3A4
5	Steroid hormone biosynthesis ³⁶ Show member pathways allopregnanolone biosynthesis ¹	11.37	CYP3A5 CYP3A4
6	Phenytoin Pathway, Pharmacokinetics ⁶⁰ Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶⁰ Carbamazepine Pathway, Pharmacokinetics ⁶⁰ Cyclophosphamide Pathway, Pharmacokinetics ⁶⁰ Efavirenz Pathway, Pharmacokinetics ⁶⁰ Sorafenib Pharmacokinetics ⁶⁰	11.34	CYP3A5 CYP3A4
7	Irinotecan Pathway, Pharmacokinetics ⁶⁰ Show member pathways Irinotecan Pathway ¹ Irinotecan Pathway, Pharmacodynamics ⁶⁰ Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.29	CYP3A5 CYP3A4
8	Androstenedione and testosterone biosynthesis and metabolism p.1 ²² Show member pathways Estrogen biosynthesis ²² Estrone metabolism ²² Steroid Biosynthesis ¹	11.24	CYP3A5 CYP3A4
9	Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Show member pathways Bosutinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Nilotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Taxane Pathway, Pharmacokinetics ⁶⁰	11.21	CYP3A5 CYP3A4
10	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶⁰	11.18	CYP3A5 CYP3A4
11	Tamoxifen metabolism ¹ Show member pathways Tamoxifen Pathway, Pharmacokinetics ⁶⁰	11.05	CYP3A5 CYP3A4
12	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.01	CYP3A5 CYP3A4
13	Erlotinib Pathway, Pharmacokinetics ⁶⁰ Show member pathways Atazanavir Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Dasatinib Pathway, Pharmacokinetics ⁶⁰ Gefitinib Pathway, Pharmacokinetics ⁶⁰	10.95	CYP3A5 CYP3A4
14	Pazopanib Pathway, Pharmacokinetics ⁶⁰ Show member pathways Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.9	CYP3A5 CYP3A4
15	Constitutive Androstane Receptor Pathway ¹	10.83	CYP3A5 CYP3A4
16	Aflatoxin activation and detoxification ⁶⁵	10.62	CYP3A5 CYP3A4
17	Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.33	CYP3A5 CYP3A4
18	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.13	CYP3A5 CYP3A4
19	Vinka Alkaloid Pathway, Pharmacokinetics ⁶⁰	9.62	CYP3A5 CYP3A4

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GO Terms for Tacrolimus Dose Selection

Cellular components related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	organelle membrane	GO:0031090	8.62	CYP3A5 CYP3A4

Biological processes related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipid metabolic process	GO:0006629	9.48	CYP3A5 CYP3A4
2	steroid metabolic process	GO:0008202	9.46	CYP3A5 CYP3A4
3	xenobiotic metabolic process	GO:0006805	9.43	CYP3A5 CYP3A4
4	retinol metabolic process	GO:0042572	9.4	CYP3A5 CYP3A4
5	retinoic acid metabolic process	GO:0042573	9.37	CYP3A5 CYP3A4
6	estrogen metabolic process	GO:0008210	9.32	CYP3A5 CYP3A4
7	oxidative demethylation	GO:0070989	9.26	CYP3A5 CYP3A4
8	lipid hydroxylation	GO:0002933	9.16	CYP3A5 CYP3A4
9	drug catabolic process	GO:0042737	8.96	CYP3A5 CYP3A4
10	alkaloid catabolic process	GO:0009822	8.62	CYP3A5 CYP3A4

Molecular functions related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.51	CYP3A5 CYP3A4
2	heme binding	GO:0020037	9.49	CYP3A5 CYP3A4
3	iron ion binding	GO:0005506	9.48	CYP3A5 CYP3A4
4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	9.46	CYP3A5 CYP3A4
5	monooxygenase activity	GO:0004497	9.43	CYP3A5 CYP3A4
6	oxygen binding	GO:0019825	9.4	CYP3A5 CYP3A4
7	steroid hydroxylase activity	GO:0008395	9.37	CYP3A5 CYP3A4
8	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO:0016712	9.32	CYP3A5 CYP3A4
9	aromatase activity	GO:0070330	9.26	CYP3A5 CYP3A4
10	retinoic acid 4-hydroxylase activity	GO:0008401	9.16	CYP3A5 CYP3A4
11	estrogen 16-alpha-hydroxylase activity	GO:0101020	8.96	CYP3A5 CYP3A4
12	testosterone 6-beta-hydroxylase activity	GO:0050649	8.62	CYP3A5 CYP3A4

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Sources for Tacrolimus Dose Selection

¹ BioSystems

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