Tacrolimus Dose Selection disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Tacrolimus Dose Selection

MalaCards integrated aliases for Tacrolimus Dose Selection:

Name: Tacrolimus Dose Selection ⁶⁰

Classifications:

MalaCards categories:
Global: Rare diseases

See all MalaCards categories (disease lists)

External Ids:

Orphanet ⁶⁰ ORPHA241043

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Summaries for Tacrolimus Dose Selection

MalaCards based summary : Tacrolimus Dose Selection is related to clopidogrel resistance. Among its related pathways/superpathways are Drug metabolism - cytochrome P450 and Paroxetine Pathway, Pharmacokinetics.

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Related Diseases for Tacrolimus Dose Selection

Diseases related to Tacrolimus Dose Selection via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	clopidogrel resistance	9.5	CYP3A4 CYP3A5

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Symptoms & Phenotypes for Tacrolimus Dose Selection

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Drugs & Therapeutics for Tacrolimus Dose Selection

Search Clinical Trials , NIH Clinical Center for Tacrolimus Dose Selection

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Genetic Tests for Tacrolimus Dose Selection

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Anatomical Context for Tacrolimus Dose Selection

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Publications for Tacrolimus Dose Selection

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Genes for Tacrolimus Dose Selection

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Variations for Tacrolimus Dose Selection

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Expression for Tacrolimus Dose Selection

Search GEO for disease gene expression data for Tacrolimus Dose Selection.

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Pathways for Tacrolimus Dose Selection

Pathways related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Drug metabolism - cytochrome P450 ³⁸ Show member pathways Aflatoxin B1 metabolism ¹ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶² Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²³ Benzodiazepine Pathway, Pharmacokinetics ⁶² Celecoxib Pathway, Pharmacokinetics ⁶² Chemical carcinogenesis ³⁸ Drug metabolism - other enzymes ³⁸ Fluvoxamine Pathway, Pharmacokinetics ⁶² Haloperidol Pathway, Pharmacokinetics ⁶² Ifosfamide Pathway, Pharmacokinetics ⁶² Metabolism of xenobiotics by cytochrome P450 ³⁸ Naproxen Pathway, Pharmacokinetics ⁶² Nicotine Metabolism ¹ Nicotine Pathway, Pharmacokinetics ⁶² Oxycodone Pathway, Pharmacokinetics ⁶² Retinol metabolism ²³ Retinol metabolism ³⁸ Sertraline Pathway, Pharmacokinetics ⁶² Voriconazole Pathway, Pharmacokinetics ⁶²	12.26	CYP3A4 CYP3A5
2	Paroxetine Pathway, Pharmacokinetics ⁶² Show member pathways Amitriptyline and Nortriptyline Pathway, Pharmacokinetics ⁶² Citalopram Pathway, Pharmacokinetics ⁶² Clomipramine Pathway, Pharmacokinetics ⁶² Clopidogrel Pathway, Pharmacokinetics ⁶² Clozapine Pathway, Pharmacokinetics ⁶² Doxepin Pathway, Pharmacokinetics ⁶² Fluoxetine Pathway, Pharmacokinetics ⁶² Gefitinib Pathway, Pharmacokinetics ⁶² Imipramine/Desipramine Pathway, Pharmacokinetics ⁶² Nevirapine Pathway, Pharmacokinetics ⁶² Olanzapine Pathway, Pharmacokinetics ⁶² Pazopanib Pathway, Pharmacokinetics ⁶² Proton Pump Inhibitor Pathway, Pharmacokinetics ⁶² Venlafaxine Pathway, Pharmacokinetics ⁶² Verapamil Pathway, Pharmacokinetics ⁶² Warfarin Pathway, Pharmacokinetics ⁶²	11.64	CYP3A4 CYP3A5
3	Statin Pathway - Generalized, Pharmacokinetics ⁶² Show member pathways Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics ⁶² Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics ⁶² Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics ⁶² Clobazam Pathway, Pharmacokinetics ⁶² Diclofenac Metabolic Pathway ¹ Diclofenac Pathway, Pharmacokinetics ⁶² Fluvastatin Pathway, Pharmacokinetics ⁶² Ibuprofen Pathway, Pharmacokinetics ⁶² Pravastatin Pathway, Pharmacokinetics ⁶² Rosiglitazone Pathway, Pharmacokinetics ⁶² Rosuvastatin Pathway, Pharmacokinetics ⁶²	11.58	CYP3A4 CYP3A5
4	Steroid hormone biosynthesis ³⁸ Show member pathways allopregnanolone biosynthesis ¹	11.31	CYP3A4 CYP3A5
5	Phenytoin Pathway, Pharmacokinetics ⁶² Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶² Carbamazepine Pathway, Pharmacokinetics ⁶² Cyclophosphamide Pathway, Pharmacokinetics ⁶² Efavirenz Pathway, Pharmacokinetics ⁶² Sorafenib Pharmacokinetics ⁶²	11.28	CYP3A4 CYP3A5
6	Androstenedione and testosterone biosynthesis and metabolism p.1 ²³ Show member pathways Estrogen biosynthesis ²³ Estrone metabolism ²³ Steroid Biosynthesis ¹	11.19	CYP3A4 CYP3A5
7	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶²	11.14	CYP3A4 CYP3A5
8	Tamoxifen metabolism ¹ Show member pathways Tamoxifen Pathway, Pharmacokinetics ⁶²	11	CYP3A4 CYP3A5
9	Constitutive Androstane Receptor Pathway ¹	10.87	CYP3A4 CYP3A5
10	Aflatoxin activation and detoxification ⁶⁷	10.68	CYP3A4 CYP3A5
11	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics ⁶²	10.43	CYP3A4 CYP3A5
12	Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics ⁶²	10.33	CYP3A4 CYP3A5
13	Taxane Pathway, Pharmacokinetics ⁶²	10.07	CYP3A4 CYP3A5
14	Vinka Alkaloid Pathway, Pharmacokinetics ⁶²	9.62	CYP3A4 CYP3A5

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GO Terms for Tacrolimus Dose Selection

Cellular components related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intracellular membrane-bounded organelle	GO:0043231	8.96	CYP3A4 CYP3A5
2	organelle membrane	GO:0031090	8.62	CYP3A4 CYP3A5

Biological processes related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	9.4	CYP3A4 CYP3A5
2	steroid metabolic process	GO:0008202	9.37	CYP3A4 CYP3A5
3	xenobiotic metabolic process	GO:0006805	9.32	CYP3A4 CYP3A5
4	oxidative demethylation	GO:0070989	9.26	CYP3A4 CYP3A5
5	drug catabolic process	GO:0042737	9.16	CYP3A4 CYP3A5
6	lipid hydroxylation	GO:0002933	8.96	CYP3A4 CYP3A5
7	alkaloid catabolic process	GO:0009822	8.62	CYP3A4 CYP3A5

Molecular functions related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.43	CYP3A4 CYP3A5
2	heme binding	GO:0020037	9.4	CYP3A4 CYP3A5
3	iron ion binding	GO:0005506	9.37	CYP3A4 CYP3A5
4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	9.32	CYP3A4 CYP3A5
5	monooxygenase activity	GO:0004497	9.26	CYP3A4 CYP3A5
6	oxygen binding	GO:0019825	9.16	CYP3A4 CYP3A5
7	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO:0016712	8.96	CYP3A4 CYP3A5
8	estrogen 16-alpha-hydroxylase activity	GO:0101020	8.62	CYP3A4 CYP3A5

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Sources for Tacrolimus Dose Selection

¹ BioSystems

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²⁵ GeneReviews

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²⁹ GO

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³⁴ ICD10

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³⁷ IUPHAR

³⁸ KEGG

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⁴⁰ LncRNADisease

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⁴⁹ NCBI Bookshelf

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⁷² TGDB

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⁷⁷ Wikipedia