MCID: TCR004
MIFTS: 13

Tacrolimus Dose Selection

Categories: Rare diseases

Aliases & Classifications for Tacrolimus Dose Selection

MalaCards integrated aliases for Tacrolimus Dose Selection:

Name: Tacrolimus Dose Selection 58

Classifications:



External Ids:

Orphanet 58 ORPHA241043

Summaries for Tacrolimus Dose Selection

MalaCards based summary : Tacrolimus Dose Selection is related to clopidogrel resistance and proctitis. An important gene associated with Tacrolimus Dose Selection is CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4), and among its related pathways/superpathways are Drug metabolism - cytochrome P450 and Statin Pathway - Generalized, Pharmacokinetics.

Related Diseases for Tacrolimus Dose Selection

Diseases related to Tacrolimus Dose Selection via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 3, show less)
# Related Disease Score Top Affiliating Genes
1 clopidogrel resistance 9.5 CYP3A5 CYP3A4
2 proctitis 9.4 CYP3A5 CYP3A4
3 neutropenia 9.2 CYP3A5 CYP3A4

Symptoms & Phenotypes for Tacrolimus Dose Selection

Drugs & Therapeutics for Tacrolimus Dose Selection

Search Clinical Trials , NIH Clinical Center for Tacrolimus Dose Selection

Genetic Tests for Tacrolimus Dose Selection

Anatomical Context for Tacrolimus Dose Selection

Publications for Tacrolimus Dose Selection

Articles related to Tacrolimus Dose Selection:

(showing 1, show less)
# Title Authors PMID Year
1
Role of pharmacogenomics in dialysis and transplantation. 61
25162201 2014

Variations for Tacrolimus Dose Selection

Expression for Tacrolimus Dose Selection

Search GEO for disease gene expression data for Tacrolimus Dose Selection.

Pathways for Tacrolimus Dose Selection

Pathways related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

(showing 19, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.31 CYP3A5 CYP3A4
2
Show member pathways
11.63 CYP3A5 CYP3A4
3
Show member pathways
11.58 CYP3A5 CYP3A4
4
Show member pathways
11.43 CYP3A5 CYP3A4
5
Show member pathways
11.37 CYP3A5 CYP3A4
6
Show member pathways
11.34 CYP3A5 CYP3A4
7
Show member pathways
11.29 CYP3A5 CYP3A4
8
Show member pathways
11.24 CYP3A5 CYP3A4
9
Show member pathways
11.21 CYP3A5 CYP3A4
10 11.18 CYP3A5 CYP3A4
11
Show member pathways
11.05 CYP3A5 CYP3A4
12 11.01 CYP3A5 CYP3A4
13
Show member pathways
10.95 CYP3A5 CYP3A4
14
Show member pathways
10.9 CYP3A5 CYP3A4
15 10.83 CYP3A5 CYP3A4
16 10.62 CYP3A5 CYP3A4
17 10.33 CYP3A5 CYP3A4
18 10.13 CYP3A5 CYP3A4
19 9.62 CYP3A5 CYP3A4

GO Terms for Tacrolimus Dose Selection

Cellular components related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.62 CYP3A5 CYP3A4

Biological processes related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

(showing 10, show less)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.48 CYP3A5 CYP3A4
2 steroid metabolic process GO:0008202 9.46 CYP3A5 CYP3A4
3 xenobiotic metabolic process GO:0006805 9.43 CYP3A5 CYP3A4
4 retinol metabolic process GO:0042572 9.4 CYP3A5 CYP3A4
5 retinoic acid metabolic process GO:0042573 9.37 CYP3A5 CYP3A4
6 estrogen metabolic process GO:0008210 9.32 CYP3A5 CYP3A4
7 oxidative demethylation GO:0070989 9.26 CYP3A5 CYP3A4
8 lipid hydroxylation GO:0002933 9.16 CYP3A5 CYP3A4
9 drug catabolic process GO:0042737 8.96 CYP3A5 CYP3A4
10 alkaloid catabolic process GO:0009822 8.62 CYP3A5 CYP3A4

Molecular functions related to Tacrolimus Dose Selection according to GeneCards Suite gene sharing:

(showing 12, show less)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.51 CYP3A5 CYP3A4
2 heme binding GO:0020037 9.49 CYP3A5 CYP3A4
3 iron ion binding GO:0005506 9.48 CYP3A5 CYP3A4
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.46 CYP3A5 CYP3A4
5 monooxygenase activity GO:0004497 9.43 CYP3A5 CYP3A4
6 oxygen binding GO:0019825 9.4 CYP3A5 CYP3A4
7 steroid hydroxylase activity GO:0008395 9.37 CYP3A5 CYP3A4
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.32 CYP3A5 CYP3A4
9 aromatase activity GO:0070330 9.26 CYP3A5 CYP3A4
10 retinoic acid 4-hydroxylase activity GO:0008401 9.16 CYP3A5 CYP3A4
11 estrogen 16-alpha-hydroxylase activity GO:0101020 8.96 CYP3A5 CYP3A4
12 testosterone 6-beta-hydroxylase activity GO:0050649 8.62 CYP3A5 CYP3A4

Sources for Tacrolimus Dose Selection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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