TA
MCID: TKY002
MIFTS: 67

Takayasu Arteritis (TA)

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Takayasu Arteritis

MalaCards integrated aliases for Takayasu Arteritis:

Name: Takayasu Arteritis 58 12 77 54 60 45 17 74
Aortic Arch Syndrome 58 12 54
Young Female Arteritis 58 54
Aortic Arch Syndromes 45 74
Takayasu's Arteritis 12 15
Aortic Arches Defect 77 54
Idiopathic Aortitis 12 74
Pulseless Disease 58 54
Aortic Arch Arteritis 12
Aortic Arch Defects 54
Takayasu's Disease 12
Takayasu Disease 54
Ta 54

Characteristics:

Orphanet epidemiological data:

60
takayasu arteritis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),1-9/100000 (Japan),1-9/1000000 (Sweden),1-9/1000000 (United Kingdom); Age of onset: Adolescent,Adult; Age of death: adult;

OMIM:

58
Inheritance:
? autosomal recessive vs. autoimmune


Classifications:



Summaries for Takayasu Arteritis

NIH Rare Diseases : 54 Takayasu arteritis is a condition that causes inflammation of the main blood vessel that carries blood from the heart to the rest of the body (aorta) and its associated branched blood vessels. As a result of the inflammation, the blood vessel walls become thick and make it difficult for blood to flow. Over time, impaired blood flow causes damage to the heart and various other organs of the body.  Although the cause remains unknown, Takayasu arteritis appears to be an autoimmune condition, in which cells that fight infection and disease are wrongly targeted against the body's own tissues.

MalaCards based summary : Takayasu Arteritis, also known as aortic arch syndrome, is related to vasculitis and myocarditis. An important gene associated with Takayasu Arteritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Omega 3 Fatty Acid and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and t cells, and related phenotypes are hyperhidrosis and fever

Disease Ontology : 12 A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body.

Wikipedia : 77 Interrupted aortic arch is a very rare heart defect (affecting 3 per million live births) in which the... more...

Description from OMIM: 207600

Related Diseases for Takayasu Arteritis

Diseases related to Takayasu Arteritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 418)
# Related Disease Score Top Affiliating Genes
1 vasculitis 32.1 CRP HLA-B SELE THBD TNF VCAM1
2 myocarditis 31.0 HLA-B IL6 TNF
3 pericarditis 30.8 CRP IL6 TNF
4 polyarteritis nodosa 30.8 CRP IL6 SELE
5 ischemic heart disease 30.7 CRP IL6 TNF
6 microscopic polyangiitis 30.7 HLA-DRB1 TNF
7 carotid stenosis 30.6 CRP MMP9 TNF
8 spondyloarthropathy 1 30.6 CRP HLA-B MMP3 TNF
9 interstitial lung disease 30.5 IL6 MMP9 TNF
10 rheumatic fever 30.5 HLA-DRB1 IL6 TNF
11 typhoid fever 30.4 CRP IL6 TNF
12 spondylitis 30.4 CRP HLA-B IL6 MICA TNF
13 scleritis 30.4 MMP9 SELE TNF
14 temporal arteritis 30.4 CRP HLA-DRB1 IL6 TNF
15 anterior uveitis 30.4 HLA-A HLA-B IL6
16 gastroenteritis 30.3 CRP IL6 TNF
17 aortic disease 30.3 CRP IL6 MMP9
18 infective endocarditis 30.3 CRP FCGR2A IL6 TNF
19 oligoarticular juvenile idiopathic arthritis 30.3 HLA-DPB1 HLA-DRB1 TNF
20 antiphospholipid syndrome 30.3 SELE THBD VCAM1 VWF
21 arteriosclerosis 30.2 CRP IL6 MMP9 SELE VCAM1
22 arthritis 30.2 HLA-DRB1 IL6 MICA MMP3 MMP9 TNF
23 heart disease 30.2 CRP IL6 MMP3 TNF VWF
24 panuveitis 30.2 HLA-A HLA-B HLA-DRB1 TNF
25 dilated cardiomyopathy 30.2 CRP HLA-DRB1 IL6 MMP9 TNF VCAM1
26 coronary stenosis 30.2 CRP IL6 VWF
27 myocardial infarction 30.1 CRP IL6 MMP3 MMP9 THBD TNF
28 multiple sclerosis 30.1 HLA-DRB1 IL12B IL6 MMP9 TNF VCAM1
29 purpura 30.1 CRP IL6 THBD TNF VWF
30 endocarditis 30.0 CRP FCGR2A IL6 TNF VCAM1
31 spondyloarthropathy 30.0 HLA-A HLA-B IL6 MMP3 TNF
32 juvenile rheumatoid arthritis 30.0 CRP HLA-DPB1 HLA-DRB1 IL6 TNF
33 kawasaki disease 29.7 CRP FCGR2A IL6 MMP3 MMP9 SELE
34 arteries, anomalies of 29.7 CRP IL6 MMP9 SELE TNF VCAM1
35 diabetes mellitus 29.5 CRP HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL6
36 cerebrovascular disease 29.4 CRP IL6 MMP9 SELE TNF VCAM1
37 rheumatoid arthritis 29.0 CRP HLA-B HLA-DPB1 HLA-DRB1 IL6 MMP3
38 systemic lupus erythematosus 28.6 CRP FCGR2A FCGR3A HLA-DPB1 HLA-DRB1 IL6
39 atypical coarctation of aorta 11.7
40 isotretinoin embryopathy-like syndrome 11.5
41 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL6 TNF
42 autoimmune myocarditis 10.6 IL6 TNF
43 leukomalacia 10.6 IL6 TNF
44 streptococcal toxic-shock syndrome 10.6 IL6 TNF
45 cryopyrin-associated periodic syndrome 10.6 CRP IL6
46 idiopathic inflammatory myopathy 10.6 HLA-B HLA-DRB1
47 diabetic foot ulcers 10.6 IL6 MMP9
48 acute transverse myelitis 10.6 IL6 MMP9
49 spastic entropion 10.5 MMP3 MMP9
50 blepharochalasis 10.5 MMP3 MMP9

Graphical network of the top 20 diseases related to Takayasu Arteritis:



Diseases related to Takayasu Arteritis

Symptoms & Phenotypes for Takayasu Arteritis

Human phenotypes related to Takayasu Arteritis:

60 33 (show all 48)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 60 33 hallmark (90%) Very frequent (99-80%) HP:0000975
2 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
3 fatigue 60 33 hallmark (90%) Very frequent (99-80%) HP:0012378
4 subcutaneous nodule 60 33 hallmark (90%) Very frequent (99-80%) HP:0001482
5 weight loss 60 33 hallmark (90%) Very frequent (99-80%) HP:0001824
6 hypertensive crisis 60 33 hallmark (90%) Very frequent (99-80%) HP:0100735
7 vasculitis 60 33 hallmark (90%) Very frequent (99-80%) HP:0002633
8 abnormal aortic arch morphology 33 hallmark (90%) HP:0012303
9 seizures 60 33 frequent (33%) Frequent (79-30%) HP:0001250
10 muscle weakness 60 33 frequent (33%) Frequent (79-30%) HP:0001324
11 arthritis 60 33 frequent (33%) Frequent (79-30%) HP:0001369
12 hypertrophic cardiomyopathy 60 33 frequent (33%) Frequent (79-30%) HP:0001639
13 anemia 60 33 frequent (33%) Frequent (79-30%) HP:0001903
14 myocardial infarction 60 33 frequent (33%) Frequent (79-30%) HP:0001658
15 pulmonary arterial hypertension 60 33 frequent (33%) Frequent (79-30%) HP:0002092
16 skin ulcer 60 33 frequent (33%) Frequent (79-30%) HP:0200042
17 anorexia 60 33 frequent (33%) Frequent (79-30%) HP:0002039
18 migraine 60 33 frequent (33%) Frequent (79-30%) HP:0002076
19 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
20 chest pain 60 33 frequent (33%) Frequent (79-30%) HP:0100749
21 inflammatory abnormality of the eye 60 33 frequent (33%) Frequent (79-30%) HP:0100533
22 gangrene 60 33 frequent (33%) Frequent (79-30%) HP:0100758
23 abnormal pattern of respiration 60 33 frequent (33%) Frequent (79-30%) HP:0002793
24 respiratory insufficiency 33 frequent (33%) HP:0002093
25 apnea 33 frequent (33%) HP:0002104
26 ascending tubular aorta aneurysm 33 frequent (33%) HP:0004970
27 abnormal aortic valve morphology 33 frequent (33%) HP:0001646
28 neurological speech impairment 60 33 occasional (7.5%) Occasional (29-5%) HP:0002167
29 reduced consciousness/confusion 60 33 occasional (7.5%) Occasional (29-5%) HP:0004372
30 retinopathy 60 33 occasional (7.5%) Occasional (29-5%) HP:0000488
31 arthralgia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002829
32 cerebral ischemia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002637
33 amaurosis fugax 60 33 occasional (7.5%) Occasional (29-5%) HP:0100576
34 hemoptysis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002105
35 gastrointestinal infarctions 60 33 occasional (7.5%) Occasional (29-5%) HP:0005244
36 recurrent respiratory infections 33 occasional (7.5%) HP:0002205
37 feeding difficulties in infancy 33 occasional (7.5%) HP:0008872
38 asthma 33 occasional (7.5%) HP:0002099
39 abnormal endocardium morphology 33 occasional (7.5%) HP:0004306
40 hypertension 60 Frequent (79-30%)
41 abnormality of the heart valves 60 Very frequent (99-80%)
42 abnormality of the aortic valve 60 Frequent (79-30%)
43 abnormality of the endocardium 60 Occasional (29-5%)
44 dilatation of the ascending aorta 60 Frequent (79-30%)
45 arterial stenosis 60 Very frequent (99-80%)
46 aneurysm 60 Very frequent (99-80%)
47 increased inflammatory response 60 Frequent (79-30%)
48 arteritis 33 HP:0012089

Symptoms via clinical synopsis from OMIM:

58
Vascular:
arteritis, major aortic branches

Limbs:
decreased pulses, upper limbs

Clinical features from OMIM:

207600

GenomeRNAi Phenotypes related to Takayasu Arteritis according to GeneCards Suite gene sharing:

27 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.77 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.77 MICA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.77 HLA-A HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.77 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.77 MICA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.77 SELE
7 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.77 HLA-A HLA-B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.77 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.77 SELE
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.77 HLA-A HLA-B MICA SELE
11 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.77 HLA-A HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.77 SELE
13 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.77 MICA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.77 MICA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.77 HLA-A HLA-B
16 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.77 HLA-A HLA-B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 MICA

MGI Mouse Phenotypes related to Takayasu Arteritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 FCGR2A IL12B IL6 MMP3 MMP9 PTX3
2 immune system MP:0005387 9.73 CRP FCGR2A IL12B IL6 MMP3 MMP9
3 respiratory system MP:0005388 9.17 IL12B IL6 MMP9 PTX3 SELE THBD

Drugs & Therapeutics for Takayasu Arteritis

Drugs for Takayasu Arteritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Omega 3 Fatty Acid Phase 4
2
leucovorin Approved Phase 3 58-05-9 6006 143
3
Mycophenolic acid Approved Phase 3 24280-93-1 446541
4
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Not Applicable 6055-19-2, 50-18-0 2907
6
Azathioprine Approved Phase 3 446-86-6 2265
7
Prednisone Approved, Vet_approved Phase 2, Phase 3,Not Applicable 53-03-2 5865
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
9 Dermatologic Agents Phase 3,Phase 2,Not Applicable
10 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
11 Folic Acid Antagonists Phase 3
12 glucocorticoids Phase 3,Phase 2,Not Applicable
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
14 Antimetabolites, Antineoplastic Phase 3,Not Applicable
15 Hormone Antagonists Phase 3,Phase 2,Not Applicable
16 Immunologic Factors Phase 3,Phase 2,Not Applicable
17 Nucleic Acid Synthesis Inhibitors Phase 3
18 Alkylating Agents Phase 3,Phase 2,Not Applicable
19 Antibiotics, Antitubercular Phase 3
20 Antitubercular Agents Phase 3
21 Vitamin B9 Phase 3
22 Folate Phase 3
23 Anti-Bacterial Agents Phase 3
24 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Not Applicable
25 Antimetabolites Phase 3,Not Applicable
26 Hormones Phase 3,Phase 2,Not Applicable
27 Vitamin B Complex Phase 3
28 Anti-Infective Agents Phase 3,Not Applicable
29 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
30 Antineoplastic Agents, Hormonal Phase 2, Phase 3,Not Applicable
31 Anti-Inflammatory Agents Phase 2, Phase 3,Not Applicable
32 Immunoglobulins Phase 3
33 Antibodies Phase 3
34
Infliximab Approved Phase 2 170277-31-3
35
Abatacept Approved Phase 2 332348-12-6 10237
36
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
37
Ethanol Approved Phase 2 64-17-5 702
38
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
39 Gastrointestinal Agents Phase 2,Not Applicable
40 Peripheral Nervous System Agents Phase 2,Not Applicable
41 Narcotics Phase 2
42 Narcotic Antagonists Phase 2
43 Analgesics Phase 2
44 Analgesics, Non-Narcotic Phase 2
45 Interleukin-2 Phase 2
46
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
47
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
48
Lenograstim Approved, Investigational Not Applicable 135968-09-1
49
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
50
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
2 Comparison of Mycophenolate Mofetil and Cyclophosphamide for Active Takayasu's Arteritis Unknown status NCT03096275 Phase 3 MMF;CYC;Glucocorticoids;MTX;AZA
3 Efficacy and Tolerance of Tocilizumab In Takayasu Arteritis Recruiting NCT02101333 Phase 3 Tocilizumab
4 Anti-inflammatory Treatment for Inactive Takayasu Arteritis Not yet recruiting NCT03550781 Phase 2, Phase 3 Prednisone, cyclophosphamide
5 Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu Arteritis Unknown status NCT02457585 Phase 2 remicade (anti tumor necrosis factor inhibitor)
6 Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis Completed NCT00556439 Phase 2 Abatacept;Placebo
7 Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis Recruiting NCT03482479 Phase 2 Naltrexone Hydrochloride
8 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2 Interleukin 2
9 Exercise in Sjogren, Myositis and Takayasu's Arteritis Unknown status NCT01501019 Not Applicable
10 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis Unknown status NCT01066208
11 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
12 Pulmonary Artery Involvement in Takayasu's Arteritis Completed NCT03189602
13 Impact and Utility of PET Versus Clinical Score for the Assessment of Inflammatory Activity in Takayasu Arteritis Completed NCT01532167
14 Use of MRI and PET for Assessing Disease Activity in Takayasu's Arteritis Completed NCT00744952
15 The Long-term Success of Cardiovascular Surgery in Takayasu Arteritis Completed NCT03654222
16 Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis Completed NCT01795456
17 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
18 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
19 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
20 Impact of Vasculitis on Employment and Income Completed NCT02476292
21 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
22 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
23 Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiS Completed NCT02042092 Not Applicable
24 Registration Study of Takayasu's Arteritis in China Recruiting NCT03199183
25 China Takayasu Arteritis Registry (CTA Registry) Recruiting NCT02964364
26 Takayasu Arteritis Clinical Trial in China Recruiting NCT02981979 Not Applicable Leflunomide 10mg Tab;Prednisone Acetate;Placebos
27 A Registry Study on Biomarkers of Takayasu's Arteritis (ARSBTA) Recruiting NCT03372980
28 Infliximab Biosimilar in Takayasu's Arteritis Recruiting NCT03192878 Infliximab
29 Determining Disease Activity Biomarkers in Individuals With Takayasu's Arteritis Recruiting NCT00315471
30 Aerobic Capacity and Strength Exercise in Takayasu's Arteritis Recruiting NCT03750929 Not Applicable
31 Exercise in Juvenile Takayasu Disease Recruiting NCT03494062 Not Applicable
32 The Registry Study of Takayasu Arteritis in East China Recruiting NCT03893136 Leflunomide
33 Study of Refractory and/or Relapsing TAkayasu aRTeritis Recruiting NCT03543527
34 VCRC Longitudinal Protocol for Aortitis Recruiting NCT03022331
35 Pediatric Vasculitis Initiative Recruiting NCT02006134
36 One-Time DNA Study for Vasculitis Recruiting NCT01241305
37 Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis Recruiting NCT02257866
38 Yellow Fever Vaccine in Patients With Rheumatic Diseases Recruiting NCT03430388 Not Applicable
39 VCRC Tissue Repository Recruiting NCT02967068
40 Vasculitis Pregnancy Registry Recruiting NCT02593565
41 Fluorine F 18 Clofarabine PET/CT in Imaging Patients With Autoimmune or Inflammatory Diseases Active, not recruiting NCT02925351 Not Applicable
42 VCRC Patient Contact Registry Patient-Reported Data Validation Study Enrolling by invitation NCT02190942
43 Thoracoscopic Vascular Rings Chart Review Terminated NCT00229853

Search NIH Clinical Center for Takayasu Arteritis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: takayasu arteritis

Genetic Tests for Takayasu Arteritis

Anatomical Context for Takayasu Arteritis

MalaCards organs/tissues related to Takayasu Arteritis:

42
Heart, Endothelial, T Cells, Bone, Eye, Skin, Kidney

Publications for Takayasu Arteritis

Articles related to Takayasu Arteritis:

(show top 50) (show all 1085)
# Title Authors Year
1
Takayasu arteritis and giant cell arteritis: are they a spectrum of the same disease? ( 29624864 )
2019
2
Radiology and biomarkers in assessing disease activity in Takayasu arteritis. ( 29624875 )
2019
3
Association of interleukin-6 and interleukin-10 expression, gene polymorphisms, and Takayasu arteritis in a Chinese Han population. ( 30171380 )
2019
4
Childhood-onset Takayasu arteritis: A 15-year experience from a tertiary referral center. ( 30397997 )
2019
5
Complex interventions of abdominal aorta and its branches in children with Takayasu arteritis: Clinical experience from a tertiary care center in north-west India. ( 30398008 )
2019
6
Transcranial Doppler Evaluation in Takayasu Arteritis With Oculo-Cerebrovascular Complications. ( 30586029 )
2019
7
Isolated Thoracic Aortic Takayasu Arteritis Presenting as Presumed Mobile Aortic Thrombus. ( 30606091 )
2019
8
Tuberculosis and Takayasu arteritis: case-based review. ( 30607506 )
2019
9
Demographic, Clinical, and Radiologic Characteristics of a Cohort of Patients with Takayasu Arteritis. ( 30615861 )
2019
10
Takayasu arteritis: differential diagnosis in a teenager with severe acute kidney injury - a case report. ( 30638252 )
2019
11
Novel Biomarkers for the Precisive Diagnosis and Activity Classification of Takayasu Arteritis. ( 30645172 )
2019
12
Value of contrast-enhanced ultrasonography of the carotid artery for evaluating disease activity in Takayasu arteritis. ( 30651132 )
2019
13
Difference in immunohistochemical characteristics between Takayasu arteritis and giant cell arteritis: it may be better to distinguish them in the same age. ( 30663925 )
2019
14
Visualization of arterial wall vascularization using superb microvascular imaging in active-stage Takayasu arteritis. ( 30668654 )
2019
15
Assessment of Disease Activity in Takayasu Arteritis: Potential Role of Contrast-Enhanced Ultrasound. ( 30674040 )
2019
16
Serum levels of fibroblast growth factor-2 distinguish Takayasu arteritis from giant cell arteritis independent of age at diagnosis. ( 30679579 )
2019
17
Takayasu arteritis: A distinct syndrome of large vessel vasculitis: A view point by late Professor Paul Bacon. ( 30698354 )
2019
18
Recent advances in the management of Takayasu arteritis. ( 30698358 )
2019
19
Diffuse vascular FDG uptake in late onset Takayasu arteritis. ( 30710544 )
2019
20
Increased incidence of spondyloarthropathies in patients with Takayasu arteritis: a systematic clinical survey. ( 30735804 )
2019
21
Takayasu Arteritis with Cerebral Hypoperfusion: An Unusual Case. ( 30766002 )
2019
22
The C-Reactive Protein/Albumin Ratio and Complete Blood Count Parameters as Indicators of Disease Activity in Patients with Takayasu Arteritis. ( 30792377 )
2019
23
Does microbiome contribute to HLA-B52-positive Takayasu arteritis? ( 30793628 )
2019
24
Statins reduce relapse rate in Takayasu arteritis. ( 30824260 )
2019
25
Contrast-enhanced Ultrasonography for Monitoring Arterial Inflammation in Takayasu Arteritis. ( 30824642 )
2019
26
Signal intensity of superb micro-vascular imaging associates with the activity of vascular inflammation in Takayasu arteritis. ( 30834495 )
2019
27
Takayasu arteritis, malignant hypertension and severe left ventricular hypertrophy. ( 30861323 )
2019
28
Malignant Ischemic Stroke in a Young Female: A Rare Primary Manifestation of Takayasu Arteritis. ( 30906605 )
2019
29
Reduced efficacy of transcatheter and surgical revascularization in Takayasu arteritis. ( 25545064 )
2019
30
Primary angiosarcoma of the femur in a patient with Takayasu arteritis. ( 29892593 )
2018
31
Stenting for middle aortic syndrome caused by Takayasu arteritis-immediate and long-term outcomes. ( 29359504 )
2018
32
Takayasu arteritis in paediatrics. ( 29233197 )
2018
33
Relapses in three patients with Takayasu arteritis under tocilizumab treatment detected by contrast enhanced ultrasound. ( 29271720 )
2018
34
Interventricular septum involvement with complete atrioventricular block as first manifestation in Takayasu arteritis. ( 29340988 )
2018
35
Takayasu arteritis revealed by unusual cutaneous manifestations. ( 29941410 )
2018
36
Takayasu arteritis a cause of hypertensive disorder of pregnancy: a case report. ( 29338776 )
2018
37
Multiple extracranial carotid aneurysms in a patient of Takayasu arteritis. ( 29735781 )
2018
38
Balloon angioplasty of renal artery stenosis due to Takayasu arteritis in a 2-year-old child. ( 29784504 )
2018
39
Axillary artery aneurysm combined with brachial plexus palsy due to Takayasu arteritis. ( 29305362 )
2018
40
Comparison between visual and numerical metrics for the evaluation of patients with Takayasu arteritis with 18F-FDG-PET. ( 29889690 )
2018
41
Efficacy of tocilizumab in Takayasu arteritis: Multicenter retrospective study of 46 patients. ( 29678346 )
2018
42
Endovascular Management of Acute Aortic Dissection in Takayasu Arteritis. ( 29860077 )
2018
43
Increased Arterial Stiffness in a Cohort of Pediatric Takayasu Arteritis Patients in Toronto Adversely Affects Left Ventricular Mechanics. ( 29782425 )
2018
44
Renovascular hypertension in small children-is it Takayasu arteritis or fibromuscular dysplasia? ( 29861130 )
2018
45
Takayasu Arteritis Coexisting with Sclerosing Osteomyelitis. ( 29434141 )
2018
46
Treatment of Takayasu arteritis with the IL-6R antibody tocilizumab vs. cyclophosphamide. ( 29729868 )
2018
47
High Secretion of Interleukin-6 and Increased MINCLE Receptor Expression Upon Exposure to Mycobacterial Cord Factor Analog Trehalose-6, 6-Dibehenate (TDB) in Patients with Takayasu Arteritis. ( 29643949 )
2018
48
Takayasu Arteritis Presenting as Unexplained Pulmonary Consolidation: A Case Report. ( 29742991 )
2018
49
Prevalence of Takayasu arteritis in young women with acute ischemic heart disease. ( 29249430 )
2018
50
Tricky case of Takayasu arteritis in a young child presenting with heart failure and femoral pulses. ( 29674517 )
2018

Variations for Takayasu Arteritis

Expression for Takayasu Arteritis

Search GEO for disease gene expression data for Takayasu Arteritis.

Pathways for Takayasu Arteritis

Pathways related to Takayasu Arteritis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 CRP FCGR2A FCGR3A HLA-A HLA-B HLA-DPB1
2
Show member pathways
13.31 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B IL6
3
Show member pathways
12.94 HLA-A HLA-B IL6 MICA MMP9 TNF
4
Show member pathways
12.91 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B IL6
5
Show member pathways
12.61 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B IL6
6
Show member pathways
12.59 HLA-DPB1 HLA-DRB1 IL12B IL6 TNF
7
Show member pathways
12.54 HLA-A HLA-B HLA-DPB1 HLA-DRB1 VCAM1
8
Show member pathways
12.52 FCGR3A HLA-A HLA-B MICA TNF
9 12.36 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL6 TNF
10
Show member pathways
12.31 IL6 MMP3 MMP9 TNF
11
Show member pathways
12.29 FCGR2A FCGR3A HLA-DPB1 HLA-DRB1 IL12B TNF
12
Show member pathways
12.26 HLA-A HLA-B IL12B IL6 TNF
13 12.18 FCGR2A FCGR3A HLA-A HLA-B HLA-DPB1 HLA-DRB1
14 12.15 MMP9 SELE THBD TNF VCAM1
15 12.13 HLA-A HLA-B HLA-DPB1 HLA-DRB1 SELE VCAM1
16 12.12 FCGR3A HLA-A HLA-B MICA VCAM1
17 12.01 FCGR2A IL6 MMP9 TNF
18
Show member pathways
12.01 FCGR2A FCGR3A IL6 MMP3 MMP9 TNF
19 11.97 IL6 SELE THBD TNF VCAM1
20 11.95 FCGR2A FCGR3A HLA-DPB1 HLA-DRB1 IL12B IL6
21 11.94 IL12B IL6 MMP3 MMP9 TNF VCAM1
22 11.91 HLA-DPB1 HLA-DRB1 IL6 TNF
23 11.91 HLA-DPB1 HLA-DRB1 IL6 MMP3 TNF
24 11.89 IL6 MMP3 MMP9 SELE TNF VCAM1
25
Show member pathways
11.86 MMP3 MMP9 TNF
26 11.85 IL12B IL6 TNF
27 11.81 MMP3 MMP9 VWF
28 11.74 IL12B IL6 TNF
29 11.74 FCGR2A FCGR3A HLA-DPB1 HLA-DRB1
30 11.72 IL6 THBD TNF
31 11.71 IL12B IL6 MMP9 PTX3 TNF
32 11.59 IL12B IL6 TNF
33 11.59 IL6 SELE TNF VCAM1
34 11.53 IL12B IL6 TNF
35 11.52 IL6 MMP9 TNF
36 11.42 MMP3 MMP9 SELE
37 11.35 IL6 MMP9 THBD
38 11.31 IL12B IL6 TNF
39 11.31 HLA-DRB1 IL12B IL6 TNF
40 11.28 FCGR2A FCGR3A IL6 MMP3 MMP9 TNF
41 11.22 IL12B IL6 SELE TNF VCAM1
42 11.07 CRP IL6 TNF
43
Show member pathways
10.9 IL6 MMP3 MMP9 SELE TNF VCAM1

GO Terms for Takayasu Arteritis

Cellular components related to Takayasu Arteritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 HLA-A HLA-B MICA SELE THBD TNF
2 extracellular space GO:0005615 9.9 CRP IL12B IL6 MICA MMP3 MMP9
3 external side of plasma membrane GO:0009897 9.72 FCGR3A HLA-DRB1 IL12B TNF VCAM1
4 ER to Golgi transport vesicle membrane GO:0012507 9.56 HLA-A HLA-B HLA-DPB1 HLA-DRB1
5 MHC class I protein complex GO:0042612 9.37 HLA-A HLA-B
6 cell surface GO:0009986 9.28 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B MICA
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B HLA-DPB1 HLA-DRB1

Biological processes related to Takayasu Arteritis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 CRP IL6 PTX3 SELE TNF
2 regulation of immune response GO:0050776 9.85 FCGR3A HLA-A HLA-B MICA VCAM1
3 extracellular matrix organization GO:0030198 9.83 MMP9 PTX3 TNF VCAM1 VWF
4 cytokine-mediated signaling pathway GO:0019221 9.8 IL12B IL6 MMP3 MMP9 TNF VCAM1
5 defense response to Gram-positive bacterium GO:0050830 9.77 CRP IL6 TNF
6 positive regulation of interferon-gamma production GO:0032729 9.67 HLA-DPB1 IL12B TNF
7 positive regulation of T cell proliferation GO:0042102 9.67 HLA-DPB1 IL12B IL6 VCAM1
8 positive regulation of T cell mediated cytotoxicity GO:0001916 9.65 HLA-A HLA-B IL12B
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.59 HLA-DPB1 HLA-DRB1
10 T-helper 1 type immune response GO:0042088 9.58 HLA-DRB1 IL12B
11 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.58 HLA-A HLA-B
12 leukocyte tethering or rolling GO:0050901 9.58 SELE TNF VCAM1
13 opsonization GO:0008228 9.57 CRP PTX3
14 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.56 HLA-A HLA-B
15 positive regulation of neuroinflammatory response GO:0150078 9.55 IL6 TNF
16 protection from natural killer cell mediated cytotoxicity GO:0042270 9.52 HLA-A HLA-B
17 regulation of neuroinflammatory response GO:0150077 9.51 MMP3 MMP9
18 antigen processing and presentation GO:0019882 9.46 HLA-A HLA-B HLA-DPB1 HLA-DRB1
19 negative regulation of lipid storage GO:0010888 9.43 CRP IL6 TNF
20 interferon-gamma-mediated signaling pathway GO:0060333 9.35 HLA-A HLA-B HLA-DPB1 HLA-DRB1 VCAM1
21 immune response GO:0006955 9.23 FCGR3A HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL6

Molecular functions related to Takayasu Arteritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 9.32 FCGR2A FCGR3A
2 virion binding GO:0046790 9.26 CRP PTX3
3 complement component C1q binding GO:0001849 9.16 CRP PTX3
4 beta-2-microglobulin binding GO:0030881 8.96 HLA-A MICA
5 peptide antigen binding GO:0042605 8.92 HLA-A HLA-B HLA-DPB1 HLA-DRB1

Sources for Takayasu Arteritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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