TA
MCID: TKY002
MIFTS: 67

Takayasu Arteritis (TA)

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Takayasu Arteritis

MalaCards integrated aliases for Takayasu Arteritis:

Name: Takayasu Arteritis 57 12 76 53 59 44 73
Aortic Arch Syndrome 57 12 53
Young Female Arteritis 57 53
Aortic Arch Syndromes 44 73
Takayasu's Arteritis 12 15
Aortic Arches Defect 76 53
Idiopathic Aortitis 12 73
Pulseless Disease 57 53
Aortic Arch Arteritis 12
Aortic Arch Defects 53
Takayasu's Disease 12
Takayasu Disease 53
Ta 53

Characteristics:

Orphanet epidemiological data:

59
takayasu arteritis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),1-9/100000 (Japan),1-9/1000000 (Sweden),1-9/1000000 (United Kingdom); Age of onset: Adolescent,Adult; Age of death: adult;

OMIM:

57
Inheritance:
? autosomal recessive vs. autoimmune


Classifications:



Summaries for Takayasu Arteritis

NIH Rare Diseases : 53 Takayasu arteritis is a condition that causes inflammation of the main blood vessel that carries blood from the heart to the rest of the body (aorta) and its associated branched blood vessels. As a result of the inflammation, the blood vessel walls become thick and make it difficult for blood to flow. Over time, impaired blood flow causes damage to the heart and various other organs of the body.  Although the cause remains unknown, Takayasu arteritis appears to be an autoimmune condition, in which cells that fight infection and disease are wrongly targeted against the body's own tissues.

MalaCards based summary : Takayasu Arteritis, also known as aortic arch syndrome, is related to vasculitis and temporal arteritis. An important gene associated with Takayasu Arteritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Omega 3 Fatty Acid and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and bone, and related phenotypes are hyperhidrosis and seizures

Disease Ontology : 12 A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body.

Wikipedia : 76 Interrupted aortic arch is a very rare heart defect (affecting 3 per million live births) in which the... more...

Description from OMIM: 207600

Related Diseases for Takayasu Arteritis

Diseases related to Takayasu Arteritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 354)
# Related Disease Score Top Affiliating Genes
1 vasculitis 32.2 CRP HLA-B SELE THBD TNF VCAM1
2 temporal arteritis 30.9 CRP HLA-DRB1 IL6 TNF
3 myocarditis 30.5 HLA-B IL6 TNF
4 pericarditis 30.5 CRP IL6 TNF
5 polyarteritis nodosa 30.5 CRP IL6 SELE
6 ischemic heart disease 30.4 CRP IL6 TNF
7 spondyloarthropathy 1 30.3 CRP HLA-B MMP3 TNF
8 aortic aneurysm, familial abdominal, 1 30.3 CRP IL6 MMP3 MMP9
9 aortic disease 30.2 CRP IL6 MMP9
10 spondylitis 30.2 CRP HLA-B IL6 MICA TNF
11 antiphospholipid syndrome 30.2 SELE THBD VCAM1 VWF
12 microscopic polyangiitis 30.2 HLA-B HLA-DRB1 TNF
13 scleritis 30.1 MMP9 SELE TNF
14 typhoid fever 30.1 CRP IL6 TNF
15 dilated cardiomyopathy 30.1 CRP HLA-DRB1 IL6 MMP9 TNF VCAM1
16 arthritis 30.1 HLA-DRB1 IL6 MICA MMP3 MMP9 TNF
17 infective endocarditis 30.1 CRP FCGR2A IL6 TNF
18 carotid stenosis 30.1 CRP MMP9 TNF
19 purpura 30.0 CRP IL6 THBD TNF VWF
20 multiple sclerosis 30.0 HLA-DRB1 IL12B IL6 MMP9 TNF VCAM1
21 angina pectoris 30.0 CRP IL6 VWF
22 alopecia areata 29.9 HLA-A HLA-DQA1 TNF
23 myocardial infarction 29.9 CRP IL6 MMP3 MMP9 PON1 THBD
24 rheumatic fever 29.9 HLA-DQA1 HLA-DRB1 IL6 TNF
25 arteriosclerosis 29.9 CRP IL6 MMP9 PON1 SELE VCAM1
26 endocarditis 29.9 CRP FCGR2A IL6 TNF VCAM1
27 heart disease 29.9 CRP IL6 MMP3 PON1 TNF VWF
28 coronary stenosis 29.9 CRP IL6 PON1 VWF
29 oligoarticular juvenile idiopathic arthritis 29.8 HLA-DPB1 HLA-DQA1 HLA-DRB1 TNF
30 celiac disease 1 29.8 HLA-A HLA-DPB1 HLA-DQA1 MICA TNF
31 juvenile rheumatoid arthritis 29.6 CRP HLA-DPB1 HLA-DQA1 HLA-DRB1 IL6 TNF
32 inflammatory bowel disease 29.4 CRP HLA-B HLA-DQA1 HLA-DRB1 IL12B IL6
33 rheumatoid arthritis 28.9 CRP HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1 IL6
34 systemic lupus erythematosus 28.8 CRP FCGR2A FCGR3A HLA-DPB1 HLA-DQA1 HLA-DRB1
35 atypical coarctation of aorta 11.7
36 isotretinoin embryopathy-like syndrome 11.5
37 ulcerative colitis 10.4
38 colitis 10.4
39 renovascular hypertension 10.4
40 aortic valve insufficiency 10.4
41 ischemia 10.4
42 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
43 leukomalacia 10.4 IL6 TNF
44 streptococcal toxic-shock syndrome 10.4 IL6 TNF
45 cold agglutinin disease 10.4 CRP IL6
46 cryopyrin-associated periodic syndrome 10.4 CRP IL6
47 idiopathic inflammatory myopathy 10.4 HLA-B HLA-DRB1
48 diabetic foot ulcers 10.4 IL6 MMP9
49 acute transverse myelitis 10.4 IL6 MMP9
50 autoimmune inner ear disease 10.4 MMP9 TNF

Graphical network of the top 20 diseases related to Takayasu Arteritis:



Diseases related to Takayasu Arteritis

Symptoms & Phenotypes for Takayasu Arteritis

Symptoms via clinical synopsis from OMIM:

57
Vascular:
arteritis, major aortic branches

Limbs:
decreased pulses, upper limbs


Clinical features from OMIM:

207600

Human phenotypes related to Takayasu Arteritis:

59 32 (show all 48)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000975
2 seizures 59 32 frequent (33%) Frequent (79-30%) HP:0001250
3 muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0001324
4 neurological speech impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0002167
5 arthritis 59 32 frequent (33%) Frequent (79-30%) HP:0001369
6 reduced consciousness/confusion 59 32 occasional (7.5%) Occasional (29-5%) HP:0004372
7 retinopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0000488
8 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
9 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
10 subcutaneous nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001482
11 arthralgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002829
12 hypertrophic cardiomyopathy 59 32 frequent (33%) Frequent (79-30%) HP:0001639
13 anemia 59 32 frequent (33%) Frequent (79-30%) HP:0001903
14 myocardial infarction 59 32 frequent (33%) Frequent (79-30%) HP:0001658
15 pulmonary arterial hypertension 59 32 frequent (33%) Frequent (79-30%) HP:0002092
16 weight loss 59 32 hallmark (90%) Very frequent (99-80%) HP:0001824
17 skin ulcer 59 32 frequent (33%) Frequent (79-30%) HP:0200042
18 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
19 migraine 59 32 frequent (33%) Frequent (79-30%) HP:0002076
20 cerebral ischemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002637
21 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
22 amaurosis fugax 59 32 occasional (7.5%) Occasional (29-5%) HP:0100576
23 hemoptysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002105
24 hypertensive crisis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100735
25 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
26 vasculitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002633
27 inflammatory abnormality of the eye 59 32 frequent (33%) Frequent (79-30%) HP:0100533
28 gastrointestinal infarctions 59 32 occasional (7.5%) Occasional (29-5%) HP:0005244
29 gangrene 59 32 frequent (33%) Frequent (79-30%) HP:0100758
30 abnormal pattern of respiration 59 32 frequent (33%) Frequent (79-30%) HP:0002793
31 hypertension 59 Frequent (79-30%)
32 respiratory insufficiency 32 frequent (33%) HP:0002093
33 recurrent respiratory infections 32 occasional (7.5%) HP:0002205
34 feeding difficulties in infancy 32 occasional (7.5%) HP:0008872
35 abnormality of the heart valves 59 Very frequent (99-80%)
36 abnormality of the aortic valve 59 Frequent (79-30%)
37 apnea 32 frequent (33%) HP:0002104
38 abnormality of the endocardium 59 Occasional (29-5%)
39 dilatation of the ascending aorta 59 Frequent (79-30%)
40 asthma 32 occasional (7.5%) HP:0002099
41 arterial stenosis 59 Very frequent (99-80%)
42 aneurysm 59 Very frequent (99-80%)
43 increased inflammatory response 59 Frequent (79-30%)
44 arteritis 32 HP:0012089
45 ascending tubular aorta aneurysm 32 frequent (33%) HP:0004970
46 abnormal aortic valve morphology 32 frequent (33%) HP:0001646
47 abnormal aortic arch morphology 32 hallmark (90%) HP:0012303
48 abnormal endocardium morphology 32 occasional (7.5%) HP:0004306

GenomeRNAi Phenotypes related to Takayasu Arteritis according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.87 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.87 MICA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.87 HLA-A HLA-B HLA-DQA1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.87 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.87 HLA-DQA1 MICA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.87 HLA-DQA1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.87 SELE
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.87 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.87 HLA-A HLA-B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.87 SELE
11 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.87 HLA-A HLA-B HLA-DQA1 MICA SELE
12 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.87 HLA-A HLA-B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.87 SELE
14 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.87 HLA-DQA1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.87 MICA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.87 MICA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.87 HLA-A HLA-B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.87 HLA-DQA1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.87 HLA-A HLA-B
20 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.87 MICA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.87 HLA-DQA1

MGI Mouse Phenotypes related to Takayasu Arteritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 FCGR2A HLA-DQA1 IL12B IL6 MMP3 MMP9
2 immune system MP:0005387 9.4 CRP FCGR2A HLA-DQA1 IL12B IL6 MMP3

Drugs & Therapeutics for Takayasu Arteritis

Drugs for Takayasu Arteritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Omega 3 Fatty Acid Phase 4
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Not Applicable 6055-19-2, 50-18-0 2907
3
Prednisone Approved, Vet_approved Phase 2, Phase 3,Not Applicable 53-03-2 5865
4
Mycophenolic acid Approved Phase 3 24280-93-1 446541
5
Azathioprine Approved Phase 3 446-86-6 2265
6
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
7
leucovorin Approved Phase 3 58-05-9 6006 143
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
9 Hormone Antagonists Phase 3,Phase 2,Not Applicable
10 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Not Applicable
11 Immunologic Factors Phase 3,Phase 2,Not Applicable
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
13 Anti-Infective Agents Phase 3,Not Applicable
14 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
15 Dermatologic Agents Phase 3,Phase 2,Not Applicable
16 glucocorticoids Phase 3,Phase 2,Not Applicable
17 Alkylating Agents Phase 3,Phase 2,Not Applicable
18 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
19 Hormones Phase 3,Phase 2,Not Applicable
20 Antineoplastic Agents, Hormonal Phase 2, Phase 3,Not Applicable
21 Anti-Inflammatory Agents Phase 2, Phase 3,Not Applicable
22 Antimetabolites Phase 3,Not Applicable
23 Immunoglobulins Phase 3
24 Antibodies Phase 3
25 Folate Phase 3
26 Vitamin B9 Phase 3
27 Vitamin B Complex Phase 3
28 Antimetabolites, Antineoplastic Phase 3,Not Applicable
29 Folic Acid Antagonists Phase 3
30 Anti-Bacterial Agents Phase 3
31 Antibiotics, Antitubercular Phase 3
32 Nucleic Acid Synthesis Inhibitors Phase 3
33 Antitubercular Agents Phase 3
34
Abatacept Approved Phase 2 332348-12-6 10237
35
Infliximab Approved Phase 2 170277-31-3
36
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
37
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
38 Gastrointestinal Agents Phase 2,Not Applicable
39 Peripheral Nervous System Agents Phase 2,Not Applicable
40 Analgesics Phase 2
41 Analgesics, Non-Narcotic Phase 2
42 Interleukin-2 Phase 2
43 Narcotic Antagonists Phase 2
44 Narcotics Phase 2
45
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
46
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
47
Lenograstim Approved, Investigational Not Applicable 135968-09-1
48
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
49
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
50
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
2 Efficacy and Tolerance of Tocilizumab In Takayasu Arteritis Recruiting NCT02101333 Phase 3 Tocilizumab
3 Comparison of Mycophenolate Mofetil and Cyclophosphamide for Active Takayasu's Arteritis Recruiting NCT03096275 Phase 3 MMF;CYC;Glucocorticoids;MTX;AZA
4 Anti-inflammatory Treatment for Inactive Takayasu Arteritis Not yet recruiting NCT03550781 Phase 2, Phase 3 Prednisone, cyclophosphamide
5 Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis Completed NCT00556439 Phase 2 Abatacept;Placebo
6 Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu Arteritis Recruiting NCT02457585 Phase 2 remicade (anti tumor necrosis factor inhibitor)
7 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2 Interleukin 2
8 Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis Not yet recruiting NCT03482479 Phase 2 Naltrexone Hydrochloride
9 Exercise in Sjogren, Myositis and Takayasu's Arteritis Unknown status NCT01501019 Not Applicable
10 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis Unknown status NCT01066208
11 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
12 Pulmonary Artery Involvement in Takayasu's Arteritis Completed NCT03189602
13 Impact and Utility of PET Versus Clinical Score for the Assessment of Inflammatory Activity in Takayasu Arteritis Completed NCT01532167
14 Use of MRI and PET for Assessing Disease Activity in Takayasu's Arteritis Completed NCT00744952
15 The Long-term Success of Cardiovascular Surgery in Takayasu Arteritis Completed NCT03654222
16 Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis Completed NCT01795456
17 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
18 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
19 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
20 Impact of Vasculitis on Employment and Income Completed NCT02476292
21 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
22 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
23 Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiS Completed NCT02042092 Not Applicable
24 Registration Study of Takayasu's Arteritis in China Recruiting NCT03199183
25 China Takayasu Arteritis Registry (CTA Registry) Recruiting NCT02964364
26 Takayasu Arteritis Clinical Trial in China Recruiting NCT02981979 Not Applicable Leflunomide 10mg Tab;Prednisone Acetate;Placebos
27 A Registry Study on Biomarkers of Takayasu's Arteritis (ARSBTA) Recruiting NCT03372980
28 Infliximab Biosimilar in Takayasu's Arteritis Recruiting NCT03192878 Infliximab
29 Determining Disease Activity Biomarkers in Individuals With Takayasu's Arteritis Recruiting NCT00315471
30 Aerobic Capacity and Strength Exercise in Takayasu's Arteritis Recruiting NCT03750929 Not Applicable
31 Exercise in Juvenile Takayasu Disease Recruiting NCT03494062 Not Applicable
32 Study of Refractory and/or Relapsing TAkayasu aRTeritis Recruiting NCT03543527
33 VCRC Longitudinal Protocol for Aortitis Recruiting NCT03022331
34 Pediatric Vasculitis Initiative Recruiting NCT02006134
35 Fluorine F 18 Clofarabine PET/CT in Imaging Patients With Autoimmune or Inflammatory Diseases Recruiting NCT02925351 Not Applicable
36 One-Time DNA Study for Vasculitis Recruiting NCT01241305
37 Yellow Fever Vaccine in Patients With Rheumatic Diseases Recruiting NCT03430388 Not Applicable
38 VCRC Tissue Repository Recruiting NCT02967068
39 Vasculitis Pregnancy Registry Recruiting NCT02593565
40 VCRC Patient Contact Registry Patient-Reported Data Validation Study Enrolling by invitation NCT02190942

Search NIH Clinical Center for Takayasu Arteritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: takayasu arteritis

Genetic Tests for Takayasu Arteritis

Anatomical Context for Takayasu Arteritis

MalaCards organs/tissues related to Takayasu Arteritis:

41
Heart, Endothelial, Bone, Skin, Kidney, Thyroid, Eye

Publications for Takayasu Arteritis

Articles related to Takayasu Arteritis:

(show top 50) (show all 1050)
# Title Authors Year
1
Nailfold videocapillaroscopy changes in Takayasu arteritis and their association with disease activity and subclavian artery involvement. ( 30389394 )
2019
2
Primary angiosarcoma of the femur in a patient with Takayasu arteritis. ( 29892593 )
2018
3
Stenting for middle aortic syndrome caused by Takayasu arteritis-immediate and long-term outcomes. ( 29359504 )
2018
4
Takayasu arteritis in paediatrics. ( 29233197 )
2018
5
Relapses in three patients with Takayasu arteritis under tocilizumab treatment detected by contrast enhanced ultrasound. ( 29271720 )
2018
6
Interventricular septum involvement with complete atrioventricular block as first manifestation in Takayasu arteritis. ( 29340988 )
2018
7
Takayasu arteritis revealed by unusual cutaneous manifestations. ( 29941410 )
2018
8
Takayasu arteritis a cause of hypertensive disorder of pregnancy: a case report. ( 29338776 )
2018
9
Multiple extracranial carotid aneurysms in a patient of Takayasu arteritis. ( 29735781 )
2018
10
Balloon angioplasty of renal artery stenosis due to Takayasu arteritis in a 2-year-old child. ( 29784504 )
2018
11
Axillary artery aneurysm combined with brachial plexus palsy due to Takayasu arteritis. ( 29305362 )
2018
12
Comparison between visual and numerical metrics for the evaluation of patients with Takayasu arteritis with 18F-FDG-PET. ( 29889690 )
2018
13
Efficacy of tocilizumab in Takayasu arteritis: Multicenter retrospective study of 46 patients. ( 29678346 )
2018
14
Endovascular Management of Acute Aortic Dissection in Takayasu Arteritis. ( 29860077 )
2018
15
Increased Arterial Stiffness in a Cohort of Pediatric Takayasu Arteritis Patients in Toronto Adversely Affects Left Ventricular Mechanics. ( 29782425 )
2018
16
Renovascular hypertension in small children-is it Takayasu arteritis or fibromuscular dysplasia? ( 29861130 )
2018
17
Takayasu Arteritis Coexisting with Sclerosing Osteomyelitis. ( 29434141 )
2018
18
Treatment of Takayasu arteritis with the IL-6R antibody tocilizumab vs. cyclophosphamide. ( 29729868 )
2018
19
High Secretion of Interleukin-6 and Increased MINCLE Receptor Expression Upon Exposure to Mycobacterial Cord Factor Analog Trehalose-6, 6-Dibehenate (TDB) in Patients with Takayasu Arteritis. ( 29643949 )
2018
20
Takayasu Arteritis Presenting as Unexplained Pulmonary Consolidation: A Case Report. ( 29742991 )
2018
21
Prevalence of Takayasu arteritis in young women with acute ischemic heart disease. ( 29249430 )
2018
22
Tricky case of Takayasu arteritis in a young child presenting with heart failure and femoral pulses. ( 29674517 )
2018
23
Abdominal pain as the presenting symptom of Takayasu arteritis in an adolescent male: A case report. ( 29953023 )
2018
24
Comment on: Rituximab therapy for Takayasu arteritis: a seven patients experience and a review of the literature: reply. ( 29385545 )
2018
25
A case of ankylosing spondylitis with concurrent Takayasu arteritis. ( 29690806 )
2018
26
Takayasu arteritis: advanced understanding is leading to new horizons. ( 29635396 )
2018
27
Comment on: Rituximab therapy for Takayasu arteritis: a seven patients experience and a review of the literature. ( 29385531 )
2018
28
OUTCOME OF ENDOVASCULAR PROCEDURES ON OCULAR FINDINGS IN TAKAYASU ARTERITIS. ( 29443797 )
2018
29
Cerebrovascular events in Takayasu arteritis: a multicenter case-controlled study. ( 29392458 )
2018
30
Involvement of the Bicuspid Aortic Valve Mimicking a Mass in Takayasu Arteritis. ( 29665041 )
2018
31
Coronary Lesions in Takayasu Arteritis With Chronic Myelogenous Leukemiaa88- Intravascular Assessment With Optical Coherence Tomography and Fractional Flow Reserve. ( 29952342 )
2018
32
Takayasu arteritis in childhood: misdiagnoses at disease onset and associated diseases. ( 29687155 )
2018
33
Esophageal Artery Pseudoaneurysm and Takayasu Arteritis in a Patient with Autosomal Dominant Polycystic Kidney Disease. ( 30046329 )
2018
34
Hemoptysis Originating from the Bronchial Artery in Takayasu Arteritis with Ulcerative Colitis. ( 30146600 )
2018
35
Takayasu Arteritis Presenting as Renovascular Hypertension and Renal Failure in a Patient with Factor VII Deficiency. ( 30515046 )
2018
36
Takayasu arteritis in young women with acute ischemic heart disease: Time to shift from anecdote to clinical practice? ( 29180268 )
2018
37
Takayasu arteritis with an initial presentation of chronic monoarthritis mimicking oligoarticular juvenile idiopathic arthritis. ( 30069294 )
2018
38
Frequency of pulmonary hypertension in transthoracic echocardiography screening is not increased in Takayasu arteritis: Experience from a single center in Turkey. ( 30501851 )
2018
39
Pulmonary hypertension in Takayasu arteritis. ( 30146739 )
2018
40
Abdominal Pyoderma Gangrenosum, Harbinger of Takayasu Arteritis in an African American Patient. ( 30044262 )
2018
41
Management of Takayasu arteritis. ( 29336164 )
2018
42
Unusual Collateral Vascular Development in a Patient with Takayasu Arteritis. ( 29455878 )
2018
43
Revascularization of Concurrent Renal and Cerebral Artery Stenosis in a 14-Year-Old Girl with Takayasu Arteritis and Moyamoya Syndrome. ( 29495141 )
2018
44
mTOR pathway is activated in endothelial cells from patients with Takayasu arteritis and is modulated by serum immunoglobulin G. ( 29506143 )
2018
45
Carbon dioxide Angiography-Guided Renal-Related Interventions in Patients with Takayasu Arteritis and Renal Insufficiency. ( 29549415 )
2018
46
Macaroni sign: Takayasu arteritis. ( 29554351 )
2018
47
Takayasu arteritis and giant cell arteritis: are they a spectrum of the same disease? ( 29624864 )
2018
48
Radiology and biomarkers in assessing disease activity in Takayasu arteritis. ( 29624875 )
2018
49
Spontaneous remission in large-vessel vasculitis: Takayasu arteritis and paraneoplastic disorder associated with thymic carcinoma. ( 29974801 )
2018
50
Extravascular manifestations of Takayasu arteritis: focusing on the features shared with spondyloarthritis. ( 29996949 )
2018

Variations for Takayasu Arteritis

Expression for Takayasu Arteritis

Search GEO for disease gene expression data for Takayasu Arteritis.

Pathways for Takayasu Arteritis

Pathways related to Takayasu Arteritis according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CRP FCGR2A FCGR3A HLA-A HLA-B HLA-DPB1
2
Show member pathways
13.45 FCGR3A HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1
3
Show member pathways
13.29 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1 IL12B
4
Show member pathways
13.04 HLA-A HLA-B IL6 MICA MMP9 TNF
5
Show member pathways
12.94 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1 IL12B
6
Show member pathways
12.87 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1 IL12B
7
Show member pathways
12.65 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL12B IL6 TNF
8
Show member pathways
12.63 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL12B TNF
9
Show member pathways
12.59 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1 VCAM1
10
Show member pathways
12.53 FCGR3A HLA-A HLA-B MICA TNF
11 12.34 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1 IL6
12
Show member pathways
12.32 IL6 MMP3 MMP9 TNF
13
Show member pathways
12.29 FCGR2A FCGR3A HLA-DPB1 HLA-DQA1 HLA-DRB1 IL12B
14
Show member pathways
12.27 HLA-A HLA-B IL12B IL6 TNF
15 12.16 MMP9 SELE THBD TNF VCAM1
16 12.16 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1 IL6
17
Show member pathways
12.14 FCGR2A FCGR3A IL6 MMP3 MMP9 TNF
18 12.13 FCGR3A HLA-A HLA-B MICA VCAM1
19 12.09 FCGR2A FCGR3A HLA-A HLA-B HLA-DPB1 HLA-DQA1
20 12.07 IL12B IL6 MMP3 MMP9 TNF VCAM1
21 12.04 IL6 MMP3 MMP9 SELE TNF VCAM1
22 12.02 FCGR2A IL6 MMP9 TNF
23 11.99 IL6 SELE THBD TNF VCAM1
24 11.98 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL6 TNF
25 11.96 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1 SELE
26 11.86 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL6 MMP3 TNF
27 11.85 IL12B IL6 TNF
28 11.82 MMP3 MMP9 VWF
29 11.75 IL12B IL6 TNF
30 11.73 IL6 THBD TNF
31 11.73 IL12B IL6 MMP9 TNF
32 11.71 FCGR2A FCGR3A HLA-DPB1 HLA-DQA1 HLA-DRB1
33 11.65 FCGR2A FCGR3A IL6 MMP3 MMP9 TNF
34 11.6 IL12B IL6 TNF
35 11.6 IL6 SELE TNF VCAM1
36 11.54 IL12B IL6 TNF
37 11.52 IL6 MMP9 TNF
38 11.48 FCGR2A FCGR3A HLA-DPB1 HLA-DQA1 HLA-DRB1 IL12B
39 11.43 MMP3 MMP9 SELE
40 11.4 IL12B IL6 SELE TNF VCAM1
41 11.36 IL6 MMP9 THBD
42 11.35 HLA-DRB1 IL12B IL6 TNF
43 11.33 IL12B IL6 TNF
44
Show member pathways
11.23 IL6 MMP3 MMP9 SELE TNF VCAM1
45 11.09 CRP IL6 TNF

GO Terms for Takayasu Arteritis

Cellular components related to Takayasu Arteritis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.83 FCGR3A HLA-DRB1 IL12B TNF VCAM1
2 trans-Golgi network membrane GO:0032588 9.69 HLA-DPB1 HLA-DQA1 HLA-DRB1
3 endocytic vesicle membrane GO:0030666 9.65 HLA-DPB1 HLA-DQA1 HLA-DRB1
4 transport vesicle membrane GO:0030658 9.63 HLA-DPB1 HLA-DQA1 HLA-DRB1
5 cell surface GO:0009986 9.61 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B MICA
6 ER to Golgi transport vesicle membrane GO:0012507 9.55 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.54 HLA-DPB1 HLA-DQA1 HLA-DRB1
8 MHC class II protein complex GO:0042613 9.5 HLA-DPB1 HLA-DQA1 HLA-DRB1
9 MHC class I protein complex GO:0042612 9.49 HLA-A HLA-B
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1
11 integral component of plasma membrane GO:0005887 10.01 HLA-A HLA-B HLA-DQA1 MICA SELE THBD
12 extracellular space GO:0005615 10 CRP IL12B IL6 MICA MMP3 MMP9

Biological processes related to Takayasu Arteritis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.86 MMP9 TNF VCAM1 VWF
2 regulation of immune response GO:0050776 9.85 FCGR3A HLA-A HLA-B MICA VCAM1
3 cytokine-mediated signaling pathway GO:0019221 9.8 IL12B IL6 MMP3 MMP9 TNF VCAM1
4 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.77 HLA-DPB1 HLA-DQA1 HLA-DRB1
5 defense response to Gram-positive bacterium GO:0050830 9.76 CRP IL6 TNF
6 positive regulation of interferon-gamma production GO:0032729 9.67 HLA-DPB1 IL12B TNF
7 positive regulation of T cell proliferation GO:0042102 9.67 HLA-DPB1 IL12B IL6 VCAM1
8 positive regulation of T cell mediated cytotoxicity GO:0001916 9.65 HLA-A HLA-B IL12B
9 leukocyte tethering or rolling GO:0050901 9.61 SELE TNF VCAM1
10 immune response GO:0006955 9.61 FCGR3A HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1
11 T-helper 1 type immune response GO:0042088 9.58 HLA-DRB1 IL12B
12 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.58 HLA-DPB1 HLA-DQA1 HLA-DRB1
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.57 HLA-A HLA-B
14 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.55 HLA-A HLA-B
15 antigen processing and presentation GO:0019882 9.55 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1
16 positive regulation of neuroinflammatory response GO:0150078 9.54 IL6 TNF
17 protection from natural killer cell mediated cytotoxicity GO:0042270 9.52 HLA-A HLA-B
18 regulation of neuroinflammatory response GO:0150077 9.51 MMP3 MMP9
19 negative regulation of lipid storage GO:0010888 9.43 CRP IL6 TNF
20 interferon-gamma-mediated signaling pathway GO:0060333 9.1 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1 VCAM1

Molecular functions related to Takayasu Arteritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 9.26 FCGR2A FCGR3A
2 MHC class II receptor activity GO:0032395 9.16 HLA-DQA1 HLA-DRB1
3 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-DPB1 HLA-DQA1 HLA-DRB1
4 beta-2-microglobulin binding GO:0030881 8.96 HLA-A MICA

Sources for Takayasu Arteritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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