MCID: TKY002
MIFTS: 66

Takayasu Arteritis

Categories: Rare diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Takayasu Arteritis

MalaCards integrated aliases for Takayasu Arteritis:

Name: Takayasu Arteritis 57 12 76 53 59 44 73
Aortic Arch Syndrome 57 12 53
Young Female Arteritis 57 53
Aortic Arch Syndromes 44 73
Takayasu's Arteritis 12 15
Aortic Arches Defect 76 53
Idiopathic Aortitis 12 73
Pulseless Disease 57 53
Aortic Arch Arteritis 12
Aortic Arch Defects 53
Takayasu's Disease 12
Takayasu Disease 53
Ta 53

Characteristics:

Orphanet epidemiological data:

59
takayasu arteritis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),1-9/100000 (Japan),1-9/1000000 (Sweden),1-9/1000000 (United Kingdom); Age of onset: Adolescent,Adult; Age of death: adult;

OMIM:

57
Inheritance:
? autosomal recessive vs. autoimmune


Classifications:



Summaries for Takayasu Arteritis

NIH Rare Diseases : 53 Takayasu arteritis is a condition that causes inflammation of the main blood vessel that carries blood from the heart to the rest of the body (aorta) and its associated branched blood vessels. As a result of the inflammation, the blood vessel walls become thick and make it difficult for blood to flow. Over time, impaired blood flow causes damage to the heart and various other organs of the body.  Although the cause remains unknown, Takayasu arteritis appears to be an autoimmune condition, in which cells that fight infection and disease are wrongly targeted against the body's own tissues.

MalaCards based summary : Takayasu Arteritis, also known as aortic arch syndrome, is related to polyarteritis nodosa and pericarditis. An important gene associated with Takayasu Arteritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Omega 3 Fatty Acid and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and skin, and related phenotypes are hyperhidrosis and seizures

Disease Ontology : 12 A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body.

Wikipedia : 76 Interrupted aortic arch is a very rare heart defect (affecting 3 per million live births) in which the... more...

Description from OMIM: 207600

Related Diseases for Takayasu Arteritis

Diseases related to Takayasu Arteritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 320)
# Related Disease Score Top Affiliating Genes
1 polyarteritis nodosa 31.1 CRP IL6 SELE
2 pericarditis 31.1 CRP IL6 TNF
3 microscopic polyangiitis 31.0 HLA-B HLA-DRB1 TNF
4 ischemic heart disease 30.9 CRP IL6 TNF
5 vasculitis 30.9 CD40LG CRP SELE THBD TNF VCAM1
6 scleritis 30.8 MMP9 SELE TNF
7 aortic disease 30.7 CRP IL6 MMP9
8 carotid stenosis 30.7 CRP MMP9 TNF
9 infective endocarditis 30.6 CRP FCGR2A IL6 TNF
10 aortic aneurysm, familial abdominal, 1 30.5 CRP IL6 MMP3 MMP9
11 rheumatic fever 30.4 CD40LG HLA-DRB1 TNF
12 churg-strauss syndrome 30.3 CD40LG THBD TNF
13 temporal arteritis 30.1 CD40LG CRP HLA-DRB1 IL6
14 pneumonia 30.1 CD40LG CRP IL6 TNF
15 endocarditis 30.1 CRP FCGR2A IL6 TNF VCAM1
16 antiphospholipid syndrome 30.0 CD40LG SELE THBD
17 spondyloarthropathy 1 29.8 CD40LG CRP HLA-B MMP3 TNF
18 purpura 29.3 CD40LG CRP THBD TNF VWF
19 spondylitis 29.3 CD40LG CRP HLA-B IL6 MICA TNF
20 wegener granulomatosis 29.3 CRP HLA-DPB1 IL6 SELE TNF VWF
21 dilated cardiomyopathy 29.1 CD40LG CRP HLA-DRB1 IL6 MMP9 TNF
22 heart disease 29.0 CRP IL6 MMP3 PON1 TNF VWF
23 arteriosclerosis 29.0 CRP IL6 MMP9 PON1 SELE THBD
24 inflammatory bowel disease 28.6 CRP HLA-B HLA-DRB1 IL12B IL6 MMP3
25 myocardial infarction 27.4 CD40LG CRP IL6 MMP3 MMP9 PON1
26 systemic lupus erythematosus 26.0 CD40LG CRP FCGR2A FCGR3A HLA-DPB1 HLA-DRB1
27 atypical coarctation of aorta 11.6
28 isotretinoin embryopathy-like syndrome 11.3
29 scorpion envenomation 11.1 IL6 TNF
30 rheumatoid nodulosis 11.0 MMP3 MMP9
31 cold agglutinin disease 11.0 CRP IL6
32 autoimmune inner ear disease 11.0 MMP9 TNF
33 intermediate uveitis 10.9 HLA-B IL6 TNF
34 phenytoin or carbamazepine toxicity 10.9 HLA-A HLA-B
35 anca-associated vasculitis 10.9 HLA-DRB1 IL6 TNF
36 microscopic colitis 10.9 HLA-DRB1 IL6 TNF
37 leukomalacia 10.9 IL6 TNF
38 louse-borne relapsing fever 10.9 CRP IL6 TNF
39 complex regional pain syndrome 10.9 HLA-B IL6 TNF
40 angioimmunoblastic lymphadenopathy with dysproteinemia 10.9 IL6 TNF
41 transverse myelitis 10.9 IL6 MMP9 TNF
42 systolic heart failure 10.9 CRP IL6 TNF
43 apnea, obstructive sleep 10.9 CRP IL6 TNF
44 perinatal necrotizing enterocolitis 10.9 CRP IL6 TNF
45 rosacea 10.9 IL6 MMP9 TNF
46 joint disorders 10.9 IL6 MMP3 TNF
47 diverticulitis 10.8 CRP MMP9 TNF
48 uterine anomalies 10.8 CRP IL6 TNF
49 pancreas disease 10.8 CRP IL6 TNF
50 endometritis 10.8 IL6 SELE TNF

Graphical network of the top 20 diseases related to Takayasu Arteritis:



Diseases related to Takayasu Arteritis

Symptoms & Phenotypes for Takayasu Arteritis

Symptoms via clinical synopsis from OMIM:

57
Vascular:
arteritis, major aortic branches

Limbs:
decreased pulses, upper limbs


Clinical features from OMIM:

207600

Human phenotypes related to Takayasu Arteritis:

59 32 (show all 48)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000975
2 seizures 59 32 frequent (33%) Frequent (79-30%) HP:0001250
3 muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0001324
4 neurological speech impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0002167
5 arthritis 59 32 frequent (33%) Frequent (79-30%) HP:0001369
6 reduced consciousness/confusion 59 32 occasional (7.5%) Occasional (29-5%) HP:0004372
7 retinopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0000488
8 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
9 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
10 subcutaneous nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001482
11 arthralgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002829
12 hypertrophic cardiomyopathy 59 32 frequent (33%) Frequent (79-30%) HP:0001639
13 anemia 59 32 frequent (33%) Frequent (79-30%) HP:0001903
14 myocardial infarction 59 32 frequent (33%) Frequent (79-30%) HP:0001658
15 pulmonary arterial hypertension 59 32 frequent (33%) Frequent (79-30%) HP:0002092
16 weight loss 59 32 hallmark (90%) Very frequent (99-80%) HP:0001824
17 skin ulcer 59 32 frequent (33%) Frequent (79-30%) HP:0200042
18 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
19 migraine 59 32 frequent (33%) Frequent (79-30%) HP:0002076
20 cerebral ischemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002637
21 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
22 amaurosis fugax 59 32 occasional (7.5%) Occasional (29-5%) HP:0100576
23 hemoptysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002105
24 hypertensive crisis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100735
25 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
26 vasculitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002633
27 inflammatory abnormality of the eye 59 32 frequent (33%) Frequent (79-30%) HP:0100533
28 gastrointestinal infarctions 59 32 occasional (7.5%) Occasional (29-5%) HP:0005244
29 gangrene 59 32 frequent (33%) Frequent (79-30%) HP:0100758
30 abnormal pattern of respiration 59 32 frequent (33%) Frequent (79-30%) HP:0002793
31 hypertension 59 Frequent (79-30%)
32 respiratory insufficiency 32 frequent (33%) HP:0002093
33 recurrent respiratory infections 32 occasional (7.5%) HP:0002205
34 feeding difficulties in infancy 32 occasional (7.5%) HP:0008872
35 abnormality of the heart valves 59 Very frequent (99-80%)
36 abnormality of the aortic valve 59 Frequent (79-30%)
37 apnea 32 frequent (33%) HP:0002104
38 abnormality of the endocardium 59 Occasional (29-5%)
39 dilatation of the ascending aorta 59 Frequent (79-30%)
40 asthma 32 occasional (7.5%) HP:0002099
41 arterial stenosis 59 Very frequent (99-80%)
42 aneurysm 59 Very frequent (99-80%)
43 increased inflammatory response 59 Frequent (79-30%)
44 arteritis 32 HP:0012089
45 ascending tubular aorta aneurysm 32 frequent (33%) HP:0004970
46 abnormal aortic valve morphology 32 frequent (33%) HP:0001646
47 abnormal aortic arch morphology 32 hallmark (90%) HP:0012303
48 abnormal endocardium morphology 32 occasional (7.5%) HP:0004306

GenomeRNAi Phenotypes related to Takayasu Arteritis according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.77 HLA-B HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.77 MICA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.77 HLA-A HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.77 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.77 MICA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.77 SELE
7 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.77 HLA-A HLA-B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.77 HLA-B HLA-A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.77 SELE
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.77 HLA-B MICA SELE HLA-A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.77 HLA-B HLA-A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.77 SELE
13 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.77 MICA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.77 MICA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.77 HLA-B HLA-A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.77 HLA-B HLA-A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 MICA

MGI Mouse Phenotypes related to Takayasu Arteritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 IL6 VWF MMP9 PON1 SELE CD40LG
2 hematopoietic system MP:0005397 9.9 IL6 VWF MMP3 MMP9 SELE CD40LG
3 homeostasis/metabolism MP:0005376 9.73 VCAM1 IL6 VWF MMP3 MMP9 PON1
4 immune system MP:0005387 9.4 IL6 VWF MMP3 MMP9 SELE CD40LG

Drugs & Therapeutics for Takayasu Arteritis

Drugs for Takayasu Arteritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Omega 3 Fatty Acid Nutraceutical Phase 4
2
Cyclophosphamide Approved, Investigational Phase 3,Not Applicable 50-18-0, 6055-19-2 2907
3
Azathioprine Approved Phase 3 446-86-6 2265
4
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
5
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
6
Mycophenolic acid Approved Phase 3 24280-93-1 446541
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
8
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
9 Alkylating Agents Phase 3,Not Applicable
10 Anti-Infective Agents Phase 3,Not Applicable
11 Antineoplastic Agents, Alkylating Phase 3,Not Applicable
12 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
13 Dermatologic Agents Phase 3,Phase 2,Not Applicable
14 glucocorticoids Phase 3,Phase 2,Not Applicable
15 Hormone Antagonists Phase 3,Not Applicable
16 Hormones Phase 3,Not Applicable
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
18 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
19 Antimetabolites Phase 3,Not Applicable
20 Antibodies Phase 3
21 Immunoglobulins Phase 3
22 Anti-Bacterial Agents Phase 3
23 Antibiotics, Antitubercular Phase 3
24 Antimetabolites, Antineoplastic Phase 3,Not Applicable
25 Antitubercular Agents Phase 3
26 Folic Acid Antagonists Phase 3
27 Nucleic Acid Synthesis Inhibitors Phase 3
28 Vitamin B Complex Phase 3
29 Folate Nutraceutical Phase 3
30 Vitamin B9 Nutraceutical Phase 3
31
Prednisone Approved, Vet_approved Phase 2,Not Applicable 53-03-2 5865
32
Abatacept Approved Phase 2 332348-12-6 10237
33
Infliximab Approved Phase 2 170277-31-3
34
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
35 Gastrointestinal Agents Phase 2,Not Applicable
36 Peripheral Nervous System Agents Phase 2,Not Applicable
37 Analgesics Phase 2
38 Analgesics, Non-Narcotic Phase 2
39 Interleukin-2 Phase 2
40
Lenograstim Approved, Investigational Not Applicable 135968-09-1
41
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
42
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
43
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
44
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
45
Leflunomide Approved, Investigational Not Applicable 75706-12-6 3899
46
Clofarabine Approved, Investigational Not Applicable 123318-82-1 119182
47
Fludarabine Approved Not Applicable 21679-14-1, 75607-67-9 30751
48
Vidarabine Approved, Investigational Not Applicable 24356-66-9 32326 21704
49
Glucosamine Approved, Investigational, Nutraceutical Not Applicable 3416-24-8 439213
50 tannic acid Approved, Nutraceutical Not Applicable

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
2 Efficacy and Tolerance of Tocilizumab In Takayasu Arteritis Recruiting NCT02101333 Phase 3 Tocilizumab
3 Comparison of Mycophenolate Mofetil and Cyclophosphamide for Active Takayasu's Arteritis Recruiting NCT03096275 Phase 3 MMF;CYC;Glucocorticoids;MTX;AZA
4 Anti-inflammatory Treatment for Inactive Takayasu Arteritis Not yet recruiting NCT03550781 Phase 2, Phase 3 Prednisone, cyclophosphamide
5 Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis Completed NCT00556439 Phase 2 Abatacept;Placebo
6 Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu Arteritis Recruiting NCT02457585 Phase 2 remicade (anti tumor necrosis factor inhibitor)
7 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2 Interleukin 2
8 Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis Not yet recruiting NCT03482479 Phase 2 Naltrexone Hydrochloride
9 Exercise in Sjogren, Myositis and Takayasu's Arteritis Unknown status NCT01501019 Not Applicable
10 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
11 Pulmonary Artery Involvement in Takayasu's Arteritis Completed NCT03189602
12 Impact and Utility of PET Versus Clinical Score for the Assessment of Inflammatory Activity in Takayasu Arteritis Completed NCT01532167
13 Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis Completed NCT01795456
14 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
15 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
16 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
17 Impact of Vasculitis on Employment and Income Completed NCT02476292
18 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
19 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
20 Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiS Completed NCT02042092 Not Applicable
21 China Takayasu Arteritis Registry (CTA Registry) Recruiting NCT02964364
22 Takayasu Arteritis Clinical Trial in China Recruiting NCT02981979 Not Applicable Leflunomide 10mg Tab;Prednisone Acetate;Placebos
23 A Registry Study on Biomarkers of Takayasu's Arteritis (ARSBTA) Recruiting NCT03372980
24 Infliximab Biosimilar in Takayasu's Arteritis Recruiting NCT03192878 Infliximab
25 Determining Disease Activity Biomarkers in Individuals With Takayasu's Arteritis Recruiting NCT00315471
26 Use of MRI and PET for Assessing Disease Activity in Takayasu's Arteritis Recruiting NCT00744952
27 Exercise in Juvenile Takayasu Disease Recruiting NCT03494062 Not Applicable
28 Study of Refractory and/or Relapsing TAkayasu aRTeritis Recruiting NCT03543527
29 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis Recruiting NCT01066208
30 VCRC Longitudinal Protocol for Aortitis Recruiting NCT03022331
31 Pediatric Vasculitis Initiative Recruiting NCT02006134
32 Fluorine F 18 Clofarabine PET/CT in Imaging Patients With Autoimmune or Inflammatory Diseases Recruiting NCT02925351 Not Applicable
33 One-Time DNA Study for Vasculitis Recruiting NCT01241305
34 Yellow Fever Vaccine in Patients With Rheumatic Diseases Recruiting NCT03430388 Not Applicable
35 VCRC Tissue Repository Recruiting NCT02967068
36 Vasculitis Pregnancy Registry Recruiting NCT02593565
37 VCRC Patient Contact Registry Patient-Reported Data Validation Study Enrolling by invitation NCT02190942
38 Registration Study of Takayasu's Arteritis in China Not yet recruiting NCT03199183

Search NIH Clinical Center for Takayasu Arteritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: aortic arch syndromes

Genetic Tests for Takayasu Arteritis

Anatomical Context for Takayasu Arteritis

MalaCards organs/tissues related to Takayasu Arteritis:

41
Heart, T Cells, Skin, Bone, Eye, Endothelial, Thyroid

Publications for Takayasu Arteritis

Articles related to Takayasu Arteritis:

(show top 50) (show all 293)
# Title Authors Year
1
Primary angiosarcoma of the femur in a patient with Takayasu arteritis. ( 29892593 )
2018
2
Stenting for middle aortic syndrome caused by Takayasu arteritis-immediate and long-term outcomes. ( 29359504 )
2018
3
Takayasu arteritis in paediatrics. ( 29233197 )
2018
4
Relapses in three patients with Takayasu arteritis under tocilizumab treatment detected by contrast enhanced ultrasound. ( 29271720 )
2018
5
Interventricular septum involvement with complete atrioventricular block as first manifestation in Takayasu arteritis. ( 29340988 )
2018
6
Takayasu arteritis revealed by unusual cutaneous manifestations. ( 29941410 )
2018
7
Takayasu arteritis a cause of hypertensive disorder of pregnancy: a case report. ( 29338776 )
2018
8
Multiple extracranial carotid aneurysms in a patient of Takayasu arteritis. ( 29735781 )
2018
9
Balloon angioplasty of renal artery stenosis due to Takayasu arteritis in a 2-year-old child. ( 29784504 )
2018
10
Axillary artery aneurysm combined with brachial plexus palsy due to Takayasu arteritis. ( 29305362 )
2018
11
Comparison between visual and numerical metrics for the evaluation of patients with Takayasu arteritis with 18F-FDG-PET. ( 29889690 )
2018
12
Efficacy of tocilizumab in Takayasu arteritis: Multicenter retrospective study of 46 patients. ( 29678346 )
2018
13
Endovascular Management of Acute Aortic Dissection in Takayasu Arteritis. ( 29860077 )
2018
14
Increased Arterial Stiffness in a Cohort of Pediatric Takayasu Arteritis Patients in Toronto Adversely Affects Left Ventricular Mechanics. ( 29782425 )
2018
15
Renovascular hypertension in small children-is it Takayasu arteritis or fibromuscular dysplasia? ( 29861130 )
2018
16
Takayasu Arteritis Coexisting with Sclerosing Osteomyelitis. ( 29434141 )
2018
17
Treatment of Takayasu arteritis with the IL-6R antibody tocilizumab vs. cyclophosphamide. ( 29729868 )
2018
18
High Secretion of Interleukin-6 and Increased MINCLE Receptor Expression Upon Exposure to Mycobacterial Cord Factor Analog Trehalose-6, 6-Dibehenate (TDB) in Patients with Takayasu Arteritis. ( 29643949 )
2018
19
Takayasu Arteritis Presenting as Unexplained Pulmonary Consolidation: A Case Report. ( 29742991 )
2018
20
Prevalence of Takayasu arteritis in young women with acute ischemic heart disease. ( 29249430 )
2018
21
Tricky case of Takayasu arteritis in a young child presenting with heart failure and femoral pulses. ( 29674517 )
2018
22
Abdominal pain as the presenting symptom of Takayasu arteritis in an adolescent male: A case report. ( 29953023 )
2018
23
Comment on: Rituximab therapy for Takayasu arteritis: a seven patients experience and a review of the literature: reply. ( 29385545 )
2018
24
A case of ankylosing spondylitis with concurrent Takayasu arteritis. ( 29690806 )
2018
25
Takayasu arteritis: advanced understanding is leading to new horizons. ( 29635396 )
2018
26
Comment on: Rituximab therapy for Takayasu arteritis: a seven patients experience and a review of the literature. ( 29385531 )
2018
27
OUTCOME OF ENDOVASCULAR PROCEDURES ON OCULAR FINDINGS IN TAKAYASU ARTERITIS. ( 29443797 )
2018
28
Cerebrovascular events in Takayasu arteritis: a multicenter case-controlled study. ( 29392458 )
2018
29
Involvement of the Bicuspid Aortic Valve Mimicking a Mass in Takayasu Arteritis. ( 29665041 )
2018
30
Coronary Lesions in Takayasu Arteritis With Chronic Myelogenous Leukemiaa88- Intravascular Assessment With Optical Coherence Tomography and Fractional Flow Reserve. ( 29952342 )
2018
31
Takayasu arteritis in childhood: misdiagnoses at disease onset and associated diseases. ( 29687155 )
2018
32
Spontaneous remission in large-vessel vasculitis: Takayasu arteritis and paraneoplastic disorder associated with thymic carcinoma. ( 29974801 )
2018
33
Management of Takayasu arteritis. ( 29336164 )
2018
34
Serial changes of carotid wall thickening on ultrasound in Takayasu arteritis. ( 28870577 )
2017
35
Takayasu arteritis (TA) first presenting with intestinal ischemia: a case report and review of gastrointestinal tract involvement (ischemic and non-ischemic) associated with TA. ( 27832292 )
2017
36
Takayasu Arteritis with Varied-size Vessel Involvement. ( 28042128 )
2017
37
What is new in management of Takayasu arteritis? ( 28774475 )
2017
38
Clinical Characteristics of Heart Involvement in Chinese Patients with Takayasu Arteritis. ( 28811356 )
2017
39
Variations in the clinical practice of physicians managing Takayasu arteritis: a nationwide survey. ( 28503078 )
2017
40
Renal Autotransplantation with Autologous Saphenous Vein Graft in a Patient with Takayasu Arteritis and Existing Renal Artery Stent in Her Solitary Kidney. ( 28486233 )
2017
41
High Signal Intensity in Arterial Walls on Diffusion-Weighted Magnetic Resonance Imaging in the Active Phase of Takayasu Arteritis. ( 28408728 )
2017
42
Erythema induratum (nodular vasculitis) associated with Takayasu arteritis. ( 28470150 )
2017
43
Sarcoidosis with Takayasu arteritis: a model of overlapping granulomatosis. A report of seven cases and literature review. ( 28791773 )
2017
44
Hybrid Coronary Artery Revascularization for Takayasu Arteritis with Major Visceral Collateral Circulation from the Left Internal Thoracic Artery. ( 28382269 )
2017
45
Are cytokines and chemokines suitable biomarkers for Takayasu arteritis? ( 28778711 )
2017
46
Takayasu arteritis presenting as isolated anterior ischemic optic neuropathy. ( 28389774 )
2017
47
Aorto-carotid bypass in patients with Takayasu arteritis. ( 28932730 )
2017
48
Clinical study of children with Takayasu arteritis: a retrospective study from a single center in China. ( 28416004 )
2017
49
Endovascular stenting of mid-aortic syndrome due to Takayasu arteritis. ( 28903623 )
2017
50
Relationship of HLA-B*51 and HLA-B*52 alleles and TNF-I+-308A/G polymorphism with susceptibility to Takayasu arteritis: a meta-analysis. ( 27815653 )
2017

Variations for Takayasu Arteritis

Expression for Takayasu Arteritis

Search GEO for disease gene expression data for Takayasu Arteritis.

Pathways for Takayasu Arteritis

Pathways related to Takayasu Arteritis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 CD40LG CRP FCGR2A FCGR3A HLA-A HLA-B
2
Show member pathways
13.45 CD40LG FCGR3A HLA-A HLA-B HLA-DPB1 HLA-DRB1
3
Show member pathways
13.04 CD40LG HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B
4
Show member pathways
12.89 CD40LG HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B
5
Show member pathways
12.81 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B IL6
6
Show member pathways
12.64 HLA-A HLA-B IL12B IL6 TNF
7
Show member pathways
12.59 HLA-A HLA-B IL6 MICA MMP9 TNF
8
Show member pathways
12.54 HLA-A HLA-B HLA-DPB1 HLA-DRB1 VCAM1
9
Show member pathways
12.52 FCGR3A HLA-A HLA-B MICA TNF
10 12.46 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL6 TNF
11
Show member pathways
12.44 HLA-DPB1 HLA-DRB1 IL12B IL6 TNF
12
Show member pathways
12.31 IL6 MMP3 MMP9 TNF
13 12.28 HLA-A HLA-B HLA-DPB1 HLA-DRB1
14 12.2 FCGR2A FCGR3A HLA-A HLA-B HLA-DPB1 HLA-DRB1
15
Show member pathways
12.18 CD40LG FCGR2A FCGR3A HLA-DPB1 HLA-DRB1 IL12B
16 12.13 CD40LG FCGR3A HLA-A HLA-B MICA VCAM1
17 12.12 MMP9 SELE THBD TNF VCAM1
18 12.05 FCGR2A FCGR3A HLA-DPB1 HLA-DRB1 IL12B IL6
19 12.01 FCGR2A IL6 MMP9 TNF
20 11.97 IL12B IL6 MMP3 MMP9 TNF VCAM1
21 11.96 IL6 SELE THBD TNF VCAM1
22 11.91 IL6 MMP3 MMP9 SELE TNF VCAM1
23 11.9 HLA-DPB1 HLA-DRB1 IL6 TNF
24 11.9 HLA-DPB1 HLA-DRB1 IL6 MMP3 TNF
25 11.81 MMP3 MMP9 VWF
26 11.74 IL12B IL6 TNF
27 11.72 IL6 THBD TNF
28 11.71 IL12B IL6 MMP9 TNF
29 11.66 CD40LG HLA-A HLA-B HLA-DPB1 HLA-DRB1 SELE
30 11.64 FCGR2A FCGR3A HLA-DPB1 HLA-DRB1
31 11.59 IL12B IL6 TNF
32 11.57 CD40LG IL6 SELE TNF VCAM1
33 11.53 IL12B IL6 TNF
34 11.52 IL6 MMP9 TNF
35 11.42 MMP3 MMP9 SELE
36 11.35 IL6 MMP9 THBD
37 11.34 HLA-DRB1 IL12B IL6 TNF
38 11.31 IL12B IL6 TNF
39 11.26 IL12B IL6 SELE TNF VCAM1
40 11.07 CRP IL6 TNF
41
Show member pathways
10.97 CD40LG IL6 MMP3 MMP9 SELE TNF

GO Terms for Takayasu Arteritis

Cellular components related to Takayasu Arteritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CD40LG CRP IL12B IL6 MICA MMP3
2 external side of plasma membrane GO:0009897 9.72 CD40LG FCGR3A HLA-DRB1 TNF VCAM1
3 ER to Golgi transport vesicle membrane GO:0012507 9.56 HLA-A HLA-B HLA-DPB1 HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.46 HLA-A HLA-B HLA-DPB1 HLA-DRB1
5 MHC class I protein complex GO:0042612 9.4 HLA-A HLA-B
6 cell surface GO:0009986 9.32 CD40LG HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B
7 extracellular region GO:0005576 10.09 CD40LG CRP IL12B IL6 MMP3 MMP9
8 extracellular exosome GO:0070062 10.07 CRP FCGR2A FCGR3A HLA-A HLA-B HLA-DRB1

Biological processes related to Takayasu Arteritis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.95 HLA-A HLA-B HLA-DRB1 MICA VCAM1
2 inflammatory response GO:0006954 9.92 CD40LG CRP IL6 SELE TNF
3 cytokine-mediated signaling pathway GO:0019221 9.88 IL12B IL6 MMP3 MMP9 TNF VCAM1
4 leukocyte migration GO:0050900 9.86 MMP9 SELE THBD TNF
5 extracellular matrix organization GO:0030198 9.84 MMP9 TNF VCAM1 VWF
6 T cell costimulation GO:0031295 9.75 CD40LG HLA-DPB1 HLA-DRB1
7 regulation of immune response GO:0050776 9.73 CD40LG FCGR3A HLA-A HLA-B MICA VCAM1
8 positive regulation of interferon-gamma production GO:0032729 9.65 HLA-DPB1 IL12B TNF
9 leukocyte cell-cell adhesion GO:0007159 9.63 CD40LG SELE VCAM1
10 antigen processing and presentation GO:0019882 9.62 HLA-A HLA-B HLA-DPB1 HLA-DRB1
11 leukocyte tethering or rolling GO:0050901 9.61 SELE TNF VCAM1
12 T-helper 1 type immune response GO:0042088 9.58 HLA-DRB1 IL12B
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.57 HLA-A HLA-B
14 immune response GO:0006955 9.56 CD40LG FCGR3A HLA-A HLA-B HLA-DPB1 HLA-DRB1
15 interferon-gamma-mediated signaling pathway GO:0060333 9.55 HLA-A HLA-B HLA-DPB1 HLA-DRB1 VCAM1
16 negative regulation of lipid storage GO:0010888 9.54 CRP IL6 TNF
17 protection from natural killer cell mediated cytotoxicity GO:0042270 9.51 HLA-A HLA-B
18 regulation of immunoglobulin secretion GO:0051023 9.49 CD40LG TNF
19 positive regulation of T cell proliferation GO:0042102 9.02 CD40LG HLA-DPB1 IL12B IL6 VCAM1

Molecular functions related to Takayasu Arteritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-2-microglobulin binding GO:0030881 9.26 HLA-A MICA
2 cytokine activity GO:0005125 9.26 CD40LG IL12B IL6 TNF
3 IgG binding GO:0019864 9.16 FCGR2A FCGR3A
4 peptide antigen binding GO:0042605 8.92 HLA-A HLA-B HLA-DPB1 HLA-DRB1

Sources for Takayasu Arteritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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