MCID: TKY002
MIFTS: 66

Takayasu Arteritis

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Takayasu Arteritis

MalaCards integrated aliases for Takayasu Arteritis:

Name: Takayasu Arteritis 58 12 77 54 60 45 17 74
Aortic Arch Syndrome 58 12 54
Young Female Arteritis 58 54
Aortic Arch Syndromes 45 74
Takayasu's Arteritis 12 15
Aortic Arches Defect 77 54
Idiopathic Aortitis 12 74
Pulseless Disease 58 54
Aortic Arch Arteritis 12
Aortic Arch Defects 54
Takayasu's Disease 12
Takayasu Disease 54
Ta 54

Characteristics:

Orphanet epidemiological data:

60
takayasu arteritis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),1-9/100000 (Japan),1-9/1000000 (Sweden),1-9/1000000 (United Kingdom); Age of onset: Adolescent,Adult; Age of death: adult;

OMIM:

58
Inheritance:
? autosomal recessive vs. autoimmune


HPO:

33
takayasu arteritis:
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Takayasu Arteritis

NIH Rare Diseases : 54 Takayasu arteritis is a condition that causes inflammation of the main blood vessel that carries blood from the heart to the rest of the body (aorta) and its associated branched blood vessels. As a result of the inflammation, the blood vessel walls become thick and make it difficult for blood to flow. Over time, impaired blood flow causes damage to the heart and various other organs of the body.  Although the cause remains unknown, Takayasu arteritis appears to be an autoimmune condition, in which cells that fight infection and disease are wrongly targeted against the body's own tissues.

MalaCards based summary : Takayasu Arteritis, also known as aortic arch syndrome, is related to vasculitis and myocarditis. An important gene associated with Takayasu Arteritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Omega 3 Fatty Acid and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and heart, and related phenotypes are hyperhidrosis and fever

Disease Ontology : 12 A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body.

Wikipedia : 77 Interrupted aortic arch is a very rare heart defect (affecting 3 per million live births) in which the... more...

Description from OMIM: 207600

Related Diseases for Takayasu Arteritis

Diseases related to Takayasu Arteritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 429)
# Related Disease Score Top Affiliating Genes
1 vasculitis 32.1 CRP HLA-B SELE THBD TNF VCAM1
2 myocarditis 31.0 HLA-B IL6 TNF
3 pericarditis 30.8 CRP IL6 TNF
4 polyarteritis nodosa 30.8 CRP IL6 SELE
5 ischemic heart disease 30.8 CRP IL6 TNF
6 microscopic polyangiitis 30.7 HLA-DRB1 TNF
7 carotid stenosis 30.6 CRP MMP9 TNF
8 spondyloarthropathy 1 30.6 CRP HLA-B MMP3 TNF
9 coronary stenosis 30.6 CRP IL6 VWF
10 interstitial lung disease 30.6 IL6 MMP9 TNF
11 rheumatic fever 30.5 HLA-DRB1 IL6 TNF
12 typhoid fever 30.5 CRP IL6 TNF
13 spondylitis 30.4 CRP HLA-B IL6 MICA TNF
14 scleritis 30.4 MMP9 SELE TNF
15 temporal arteritis 30.4 CRP HLA-DRB1 IL6 TNF
16 anterior uveitis 30.4 HLA-A HLA-B IL6
17 antiphospholipid syndrome 30.4 SELE THBD VCAM1 VWF
18 gastroenteritis 30.4 CRP IL6 TNF
19 aortic disease 30.3 CRP IL6 MMP9
20 infective endocarditis 30.3 CRP FCGR2A IL6 TNF
21 oligoarticular juvenile idiopathic arthritis 30.3 HLA-DPB1 HLA-DRB1 TNF
22 arteriosclerosis 30.2 CRP IL6 MMP9 SELE VCAM1
23 arthritis 30.2 HLA-DRB1 IL6 MICA MMP3 MMP9 TNF
24 heart disease 30.2 CRP IL6 MMP3 TNF VWF
25 panuveitis 30.2 HLA-A HLA-B HLA-DRB1 TNF
26 dilated cardiomyopathy 30.2 CRP HLA-DRB1 IL6 MMP9 TNF VCAM1
27 myocardial infarction 30.2 CRP IL6 MMP3 MMP9 THBD TNF
28 multiple sclerosis 30.2 HLA-DRB1 IL12B IL6 MMP9 TNF VCAM1
29 purpura 30.1 CRP IL6 THBD TNF VWF
30 endocarditis 30.1 CRP FCGR2A IL6 TNF VCAM1
31 spondyloarthropathy 30.1 HLA-A HLA-B IL6 MMP3 TNF
32 juvenile rheumatoid arthritis 30.0 CRP HLA-DPB1 HLA-DRB1 IL6 TNF
33 kawasaki disease 29.7 CRP FCGR2A IL6 MMP3 MMP9 SELE
34 arteries, anomalies of 29.7 CRP IL6 MMP9 SELE TNF VCAM1
35 diabetes mellitus 29.5 CRP HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL6
36 cerebrovascular disease 29.5 CRP IL6 MMP9 SELE TNF VCAM1
37 rheumatoid arthritis 29.0 CRP HLA-B HLA-DPB1 HLA-DRB1 IL6 MMP3
38 systemic lupus erythematosus 28.6 CRP FCGR2A FCGR3A HLA-DPB1 HLA-DRB1 IL6
39 atypical coarctation of aorta 11.8
40 isotretinoin embryopathy-like syndrome 11.5
41 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL6 TNF
42 autoimmune myocarditis 10.6 IL6 TNF
43 leukomalacia 10.6 IL6 TNF
44 streptococcal toxic-shock syndrome 10.6 IL6 TNF
45 cryopyrin-associated periodic syndrome 10.6 CRP IL6
46 idiopathic inflammatory myopathy 10.6 HLA-B HLA-DRB1
47 diabetic foot ulcers 10.6 IL6 MMP9
48 acute transverse myelitis 10.6 IL6 MMP9
49 spastic entropion 10.5 MMP3 MMP9
50 blepharochalasis 10.5 MMP3 MMP9

Graphical network of the top 20 diseases related to Takayasu Arteritis:



Diseases related to Takayasu Arteritis

Symptoms & Phenotypes for Takayasu Arteritis

Human phenotypes related to Takayasu Arteritis:

60 33 (show all 48)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 60 33 hallmark (90%) Very frequent (99-80%) HP:0000975
2 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
3 fatigue 60 33 hallmark (90%) Very frequent (99-80%) HP:0012378
4 subcutaneous nodule 60 33 hallmark (90%) Very frequent (99-80%) HP:0001482
5 weight loss 60 33 hallmark (90%) Very frequent (99-80%) HP:0001824
6 hypertensive crisis 60 33 hallmark (90%) Very frequent (99-80%) HP:0100735
7 vasculitis 60 33 hallmark (90%) Very frequent (99-80%) HP:0002633
8 abnormal aortic arch morphology 33 hallmark (90%) HP:0012303
9 seizures 60 33 frequent (33%) Frequent (79-30%) HP:0001250
10 muscle weakness 60 33 frequent (33%) Frequent (79-30%) HP:0001324
11 arthritis 60 33 frequent (33%) Frequent (79-30%) HP:0001369
12 hypertrophic cardiomyopathy 60 33 frequent (33%) Frequent (79-30%) HP:0001639
13 anemia 60 33 frequent (33%) Frequent (79-30%) HP:0001903
14 myocardial infarction 60 33 frequent (33%) Frequent (79-30%) HP:0001658
15 pulmonary arterial hypertension 60 33 frequent (33%) Frequent (79-30%) HP:0002092
16 skin ulcer 60 33 frequent (33%) Frequent (79-30%) HP:0200042
17 anorexia 60 33 frequent (33%) Frequent (79-30%) HP:0002039
18 migraine 60 33 frequent (33%) Frequent (79-30%) HP:0002076
19 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
20 chest pain 60 33 frequent (33%) Frequent (79-30%) HP:0100749
21 inflammatory abnormality of the eye 60 33 frequent (33%) Frequent (79-30%) HP:0100533
22 gangrene 60 33 frequent (33%) Frequent (79-30%) HP:0100758
23 abnormal pattern of respiration 60 33 frequent (33%) Frequent (79-30%) HP:0002793
24 respiratory insufficiency 33 frequent (33%) HP:0002093
25 apnea 33 frequent (33%) HP:0002104
26 ascending tubular aorta aneurysm 33 frequent (33%) HP:0004970
27 abnormal aortic valve morphology 33 frequent (33%) HP:0001646
28 neurological speech impairment 60 33 occasional (7.5%) Occasional (29-5%) HP:0002167
29 reduced consciousness/confusion 60 33 occasional (7.5%) Occasional (29-5%) HP:0004372
30 retinopathy 60 33 occasional (7.5%) Occasional (29-5%) HP:0000488
31 arthralgia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002829
32 cerebral ischemia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002637
33 amaurosis fugax 60 33 occasional (7.5%) Occasional (29-5%) HP:0100576
34 hemoptysis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002105
35 gastrointestinal infarctions 60 33 occasional (7.5%) Occasional (29-5%) HP:0005244
36 recurrent respiratory infections 33 occasional (7.5%) HP:0002205
37 feeding difficulties in infancy 33 occasional (7.5%) HP:0008872
38 asthma 33 occasional (7.5%) HP:0002099
39 abnormal endocardium morphology 33 occasional (7.5%) HP:0004306
40 hypertension 60 Frequent (79-30%)
41 abnormality of the heart valves 60 Very frequent (99-80%)
42 abnormality of the aortic valve 60 Frequent (79-30%)
43 abnormality of the endocardium 60 Occasional (29-5%)
44 dilatation of the ascending aorta 60 Frequent (79-30%)
45 arterial stenosis 60 Very frequent (99-80%)
46 aneurysm 60 Very frequent (99-80%)
47 increased inflammatory response 60 Frequent (79-30%)
48 arteritis 33 HP:0012089

Symptoms via clinical synopsis from OMIM:

58
Vascular:
arteritis, major aortic branches

Limbs:
decreased pulses, upper limbs

Clinical features from OMIM:

207600

GenomeRNAi Phenotypes related to Takayasu Arteritis according to GeneCards Suite gene sharing:

27 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.77 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.77 MICA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.77 HLA-A HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.77 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.77 MICA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.77 SELE
7 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.77 HLA-A HLA-B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.77 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.77 SELE
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.77 HLA-A HLA-B MICA SELE
11 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.77 HLA-A HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.77 SELE
13 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.77 MICA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.77 MICA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.77 HLA-A HLA-B
16 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.77 HLA-A HLA-B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 MICA

MGI Mouse Phenotypes related to Takayasu Arteritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 FCGR2A IL12B IL6 MMP3 MMP9 PTX3
2 immune system MP:0005387 9.73 CRP FCGR2A IL12B IL6 MMP3 MMP9
3 respiratory system MP:0005388 9.17 IL12B IL6 MMP9 PTX3 SELE THBD

Drugs & Therapeutics for Takayasu Arteritis

Drugs for Takayasu Arteritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Omega 3 Fatty Acid Phase 4
2
leucovorin Approved Phase 3 58-05-9 143 6006
3
Azathioprine Approved Phase 3 446-86-6 2265
4
Mycophenolic acid Approved Phase 3 24280-93-1 446541
5
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
6
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Not Applicable 50-18-0, 6055-19-2 2907
7
Prednisone Approved, Vet_approved Phase 2, Phase 3,Not Applicable 53-03-2 5865
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
9 Antibiotics, Antitubercular Phase 3
10 Antimetabolites, Antineoplastic Phase 3,Not Applicable
11 Vitamin B9 Phase 3
12 glucocorticoids Phase 3,Phase 2,Not Applicable
13 Anti-Infective Agents Phase 3,Not Applicable
14 Hormone Antagonists Phase 3,Phase 2,Not Applicable
15 Antitubercular Agents Phase 3
16 Alkylating Agents Phase 3,Phase 2,Not Applicable
17 Immunologic Factors Phase 3,Phase 2,Not Applicable
18 Hormones Phase 3,Phase 2,Not Applicable
19 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
20 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
21 Anti-Bacterial Agents Phase 3
22 Vitamin B Complex Phase 3
23 Folic Acid Antagonists Phase 3
24 Folate Phase 3
25 Nucleic Acid Synthesis Inhibitors Phase 3
26 Antimetabolites Phase 3,Not Applicable
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
28 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Not Applicable
29 Dermatologic Agents Phase 3,Phase 2,Not Applicable
30 Anti-Inflammatory Agents Phase 2, Phase 3,Not Applicable
31 Antineoplastic Agents, Hormonal Phase 2, Phase 3,Not Applicable
32 Antibodies Phase 3
33 Immunoglobulins Phase 3
34
Infliximab Approved Phase 2 170277-31-3
35
Abatacept Approved Phase 2 332348-12-6 10237
36
Ethanol Approved Phase 2 64-17-5 702
37
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
38
Aldesleukin Approved Phase 2 110942-02-4, 85898-30-2
39 Gastrointestinal Agents Phase 2,Not Applicable
40 Peripheral Nervous System Agents Phase 2,Not Applicable
41 Narcotics Phase 2
42 Narcotic Antagonists Phase 2
43 Analgesics Phase 2
44 Interleukin-2 Phase 2
45 Analgesics, Non-Narcotic Phase 2
46
Lenograstim Approved, Investigational Not Applicable 135968-09-1
47
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
48
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
49
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
50
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
2 Comparison of Mycophenolate Mofetil and Cyclophosphamide for Active Takayasu's Arteritis Unknown status NCT03096275 Phase 3 MMF;CYC;Glucocorticoids;MTX;AZA
3 Efficacy and Tolerance of Tocilizumab In Takayasu Arteritis Recruiting NCT02101333 Phase 3 Tocilizumab
4 Anti-inflammatory Treatment for Inactive Takayasu Arteritis Not yet recruiting NCT03550781 Phase 2, Phase 3 Prednisone, cyclophosphamide
5 Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu Arteritis Unknown status NCT02457585 Phase 2 remicade (anti tumor necrosis factor inhibitor)
6 Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis Completed NCT00556439 Phase 2 Abatacept;Placebo
7 Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis Recruiting NCT03482479 Phase 2 Naltrexone Hydrochloride
8 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2 Interleukin 2
9 Exercise in Sjogren, Myositis and Takayasu's Arteritis Unknown status NCT01501019 Not Applicable
10 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis Unknown status NCT01066208
11 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
12 Pulmonary Artery Involvement in Takayasu's Arteritis Completed NCT03189602
13 Impact and Utility of PET Versus Clinical Score for the Assessment of Inflammatory Activity in Takayasu Arteritis Completed NCT01532167
14 Use of MRI and PET for Assessing Disease Activity in Takayasu's Arteritis Completed NCT00744952
15 The Long-term Success of Cardiovascular Surgery in Takayasu Arteritis Completed NCT03654222
16 Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis Completed NCT01795456
17 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
18 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
19 Yellow Fever Vaccine in Patients With Rheumatic Diseases Completed NCT03430388 Not Applicable
20 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
21 Impact of Vasculitis on Employment and Income Completed NCT02476292
22 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
23 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
24 Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiS Completed NCT02042092 Not Applicable
25 Registration Study of Takayasu's Arteritis in China Recruiting NCT03199183
26 China Takayasu Arteritis Registry (CTA Registry) Recruiting NCT02964364
27 Takayasu Arteritis Clinical Trial in China Recruiting NCT02981979 Not Applicable Leflunomide 10mg Tab;Prednisone Acetate;Placebos
28 A Registry Study on Biomarkers of Takayasu's Arteritis (ARSBTA) Recruiting NCT03372980
29 Infliximab Biosimilar in Takayasu's Arteritis Recruiting NCT03192878 Infliximab
30 Determining Disease Activity Biomarkers in Individuals With Takayasu's Arteritis Recruiting NCT00315471
31 Aerobic Capacity and Strength Exercise in Takayasu's Arteritis Recruiting NCT03750929 Not Applicable
32 Exercise in Juvenile Takayasu Disease Recruiting NCT03494062 Not Applicable
33 The Registry Study of Takayasu Arteritis in East China Recruiting NCT03893136 Leflunomide
34 Study of Refractory and/or Relapsing TAkayasu aRTeritis Recruiting NCT03543527
35 VCRC Longitudinal Protocol for Aortitis Recruiting NCT03022331
36 Pediatric Vasculitis Initiative Recruiting NCT02006134
37 One-Time DNA Study for Vasculitis Recruiting NCT01241305
38 Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis Recruiting NCT02257866
39 Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity Recruiting NCT03941184
40 VCRC Tissue Repository Recruiting NCT02967068
41 Vasculitis Pregnancy Registry Recruiting NCT02593565
42 Fluorine F 18 Clofarabine PET/CT in Imaging Patients With Autoimmune or Inflammatory Diseases Active, not recruiting NCT02925351 Not Applicable
43 VCRC Patient Contact Registry Patient-Reported Data Validation Study Enrolling by invitation NCT02190942
44 Takayasu Arteritis Activity Evaluation by Ultrafast Ultrasound Imaging Not yet recruiting NCT03956394 Not Applicable
45 Immunome Project Consortium for Autoinflammatory Disorders Not yet recruiting NCT03919110
46 Thoracoscopic Vascular Rings Chart Review Terminated NCT00229853

Search NIH Clinical Center for Takayasu Arteritis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: takayasu arteritis

Genetic Tests for Takayasu Arteritis

Anatomical Context for Takayasu Arteritis

MalaCards organs/tissues related to Takayasu Arteritis:

42
Kidney, Skin, Heart, Thyroid, Eye, Endothelial, T Cells

Publications for Takayasu Arteritis

Articles related to Takayasu Arteritis:

(show top 50) (show all 1120)
# Title Authors Year
1
Acute myocardial infarction as the first manifestation of Takayasu arteritis: A case report. ( 30985685 )
2019
2
A Long-term Survival after Surgical Treatment for Atypical Aortic Coarctation Complicating Takayasu Arteritis with Inactive Disease at the Diagnosis: An Appropriately Treated Autopsy Case. ( 30996177 )
2019
3
Interventricular septum involvement with complete atrioventricular block as first manifestation in Takayasu arteritis. ( 29340988 )
2019
4
Hemoptysis Originating from the Bronchial Artery in Takayasu Arteritis with Ulcerative Colitis. ( 30146600 )
2019
5
Multimodality findings of coronary stenosis and aneurysm in Takayasu arteritis: a case report. ( 30998608 )
2019
6
Takayasu arteritis, malignant hypertension and severe left ventricular hypertrophy. ( 30861323 )
2019
7
Successful Hybrid Zone 0 Landing Thoracic Endovascular Aortic Repair for Ascending Aortic Pseudoaneurysm after Bentall Procedure and Coronary Artery Bypass Grafting in Takayasu Arteritis. ( 30114506 )
2019
8
Association of interleukin-6 and interleukin-10 expression, gene polymorphisms, and Takayasu arteritis in a Chinese Han population. ( 30171380 )
2019
9
Management and evaluation of pregnant women with Takayasu arteritis. ( 30302544 )
2019
10
Nailfold videocapillaroscopy changes in Takayasu arteritis and their association with disease activity and subclavian artery involvement. ( 30389394 )
2019
11
Childhood-onset Takayasu arteritis: A 15-year experience from a tertiary referral center. ( 30397997 )
2019
12
Complex interventions of abdominal aorta and its branches in children with Takayasu arteritis: Clinical experience from a tertiary care center in north-west India. ( 30398008 )
2019
13
Transcranial Doppler Evaluation in Takayasu Arteritis With Oculo-Cerebrovascular Complications. ( 30586029 )
2019
14
Childhood- Versus Adult-Onset Takayasu Arteritis: Are They Really Different? Comment on the Article by Aeschlimann et al. ( 30592389 )
2019
15
Isolated Thoracic Aortic Takayasu Arteritis Presenting as Presumed Mobile Aortic Thrombus. ( 30606091 )
2019
16
Tuberculosis and Takayasu arteritis: case-based review. ( 30607506 )
2019
17
Demographic, Clinical, and Radiologic Characteristics of a Cohort of Patients with Takayasu Arteritis. ( 30615861 )
2019
18
Takayasu arteritis: differential diagnosis in a teenager with severe acute kidney injury - a case report. ( 30638252 )
2019
19
Novel Biomarkers for the Precisive Diagnosis and Activity Classification of Takayasu Arteritis. ( 30645172 )
2019
20
Value of contrast-enhanced ultrasonography of the carotid artery for evaluating disease activity in Takayasu arteritis. ( 30651132 )
2019
21
Difference in immunohistochemical characteristics between Takayasu arteritis and giant cell arteritis: It may be better to distinguish them in the same age. ( 30663925 )
2019
22
Visualization of arterial wall vascularization using superb microvascular imaging in active-stage Takayasu arteritis. ( 30668654 )
2019
23
Assessment of Disease Activity in Takayasu Arteritis: Potential Role of Contrast-Enhanced Ultrasound. ( 30674040 )
2019
24
Serum levels of fibroblast growth factor-2 distinguish Takayasu arteritis from giant cell arteritis independent of age at diagnosis. ( 30679579 )
2019
25
Takayasu arteritis: A distinct syndrome of large vessel vasculitis: A view point by late Professor Paul Bacon. ( 30698354 )
2019
26
Recent advances in the management of Takayasu arteritis. ( 30698358 )
2019
27
Diffuse Vascular FDG Uptake in Late Onset Takayasu Arteritis. ( 30710544 )
2019
28
Takayasu's Arteritis and Sarcoidosis in the Era of Advanced Molecular Imaging. ( 30714676 )
2019
29
Increased incidence of spondyloarthropathies in patients with Takayasu arteritis: a systematic clinical survey. ( 30735804 )
2019
30
Takayasu Arteritis with Cerebral Hypoperfusion: An Unusual Case. ( 30766002 )
2019
31
The C-Reactive Protein/Albumin Ratio and Complete Blood Count Parameters as Indicators of Disease Activity in Patients with Takayasu Arteritis. ( 30792377 )
2019
32
Does microbiome contribute to HLA-B52-positive Takayasu arteritis? ( 30793628 )
2019
33
Statins reduce relapse rate in Takayasu arteritis. ( 30824260 )
2019
34
Contrast-enhanced Ultrasonography for Monitoring Arterial Inflammation in Takayasu Arteritis. ( 30824642 )
2019
35
Signal intensity of superb micro-vascular imaging associates with the activity of vascular inflammation in Takayasu arteritis. ( 30834495 )
2019
36
Malignant Ischemic Stroke in a Young Female: A Rare Primary Manifestation of Takayasu Arteritis. ( 30906605 )
2019
37
Endovascular treatment for multiple aortic narrowings in a patient with Takayasu arteritis. ( 30926210 )
2019
38
Takayasu Arteritis with Atrial Septal Defect Presenting as Sterile Corneal Melt. ( 30935183 )
2019
39
Regressed coronary ostial stenosis in a young female with Takayasu arteritis: a case report. ( 30940076 )
2019
40
Nephrotic range proteinuria and metabolic alkalosis in Takayasu arteritis. ( 30992286 )
2019
41
Aortic dilatation in a patient with Takayasu arteritis treated with tocilizumab. ( 30992294 )
2019
42
Late presentation of Takayasu arteritis in geriatric patients. ( 30993658 )
2019
43
Long-term peritoneal dialysis followed by kidney transplantation for Takayasu arteritis: a case report. ( 30999953 )
2019
44
Statin therapy for Takayasu Arteritis. ( 31005412 )
2019
45
Back Pain: A Rare Presentation of Takayasu Arteritis. ( 31007986 )
2019
46
Takayasu arteritis with multiple coronary involvement and early graft relapse. ( 31040146 )
2019
47
Takayasu arteritis: Anaesthetic implications in caesarean section. ( 31054521 )
2019
48
Gender differences in clinical presentation and vascular pattern in patients with Takayasu arteritis. ( 31064248 )
2019
49
Renal artery reconstruction and kidney autotransplantation for Takayasu arteritis-induced renal artery stenosis. ( 31065612 )
2019
50
Plasma infliximab monitoring contributes to optimize Takayasu arteritis treatment: a case report. ( 31073411 )
2019

Variations for Takayasu Arteritis

Expression for Takayasu Arteritis

Search GEO for disease gene expression data for Takayasu Arteritis.

Pathways for Takayasu Arteritis

Pathways related to Takayasu Arteritis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 CRP FCGR2A FCGR3A HLA-A HLA-B HLA-DPB1
2
Show member pathways
13.31 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B IL6
3
Show member pathways
12.94 HLA-A HLA-B IL6 MICA MMP9 TNF
4
Show member pathways
12.91 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B IL6
5
Show member pathways
12.59 HLA-DPB1 HLA-DRB1 IL12B IL6 TNF
6
Show member pathways
12.53 HLA-A HLA-B HLA-DPB1 HLA-DRB1 VCAM1
7
Show member pathways
12.51 FCGR3A HLA-A HLA-B MICA TNF
8 12.36 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL6 TNF
9
Show member pathways
12.31 IL6 MMP3 MMP9 TNF
10
Show member pathways
12.29 FCGR2A FCGR3A HLA-DPB1 HLA-DRB1 IL12B TNF
11
Show member pathways
12.26 HLA-A HLA-B IL12B IL6 TNF
12 12.18 FCGR2A FCGR3A HLA-A HLA-B HLA-DPB1 HLA-DRB1
13 12.14 MMP9 SELE THBD TNF VCAM1
14 12.14 HLA-A HLA-B HLA-DPB1 HLA-DRB1 SELE VCAM1
15 12.11 FCGR3A HLA-A HLA-B MICA VCAM1
16
Show member pathways
12.01 FCGR2A FCGR3A IL6 MMP3 MMP9 TNF
17 12 FCGR2A IL6 MMP9 TNF
18 11.97 IL6 SELE THBD TNF VCAM1
19 11.95 FCGR2A FCGR3A HLA-DPB1 HLA-DRB1 IL12B IL6
20 11.94 IL12B IL6 MMP3 MMP9 TNF VCAM1
21 11.91 HLA-DPB1 HLA-DRB1 IL6 MMP3 TNF
22 11.9 HLA-DPB1 HLA-DRB1 IL6 TNF
23 11.89 IL6 MMP3 MMP9 SELE TNF VCAM1
24
Show member pathways
11.86 MMP3 MMP9 TNF
25 11.84 IL12B IL6 TNF
26 11.81 MMP3 MMP9 VWF
27 11.74 IL12B IL6 TNF
28 11.74 FCGR2A FCGR3A HLA-DPB1 HLA-DRB1
29 11.72 IL6 THBD TNF
30 11.71 IL12B IL6 MMP9 PTX3 TNF
31 11.58 IL12B IL6 TNF
32 11.58 IL6 SELE TNF VCAM1
33 11.53 IL12B IL6 TNF
34 11.52 IL6 MMP9 TNF
35 11.41 MMP3 MMP9 SELE
36 11.34 IL6 MMP9 THBD
37 11.31 IL12B IL6 TNF
38 11.31 HLA-DRB1 IL12B IL6 TNF
39 11.28 FCGR2A FCGR3A IL6 MMP3 MMP9 TNF
40 11.22 IL12B IL6 SELE TNF VCAM1
41 11.07 CRP IL6 TNF
42
Show member pathways
10.9 IL6 MMP3 MMP9 SELE TNF VCAM1

GO Terms for Takayasu Arteritis

Cellular components related to Takayasu Arteritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 HLA-A HLA-B MICA SELE THBD TNF
2 extracellular space GO:0005615 9.9 CRP IL12B IL6 MICA MMP3 MMP9
3 external side of plasma membrane GO:0009897 9.72 FCGR3A HLA-DRB1 IL12B TNF VCAM1
4 ER to Golgi transport vesicle membrane GO:0012507 9.56 HLA-A HLA-B HLA-DPB1 HLA-DRB1
5 MHC class I protein complex GO:0042612 9.37 HLA-A HLA-B
6 cell surface GO:0009986 9.28 HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL12B MICA
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B HLA-DPB1 HLA-DRB1

Biological processes related to Takayasu Arteritis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 CRP IL6 PTX3 SELE TNF
2 regulation of immune response GO:0050776 9.85 FCGR3A HLA-A HLA-B MICA VCAM1
3 extracellular matrix organization GO:0030198 9.83 MMP9 PTX3 TNF VCAM1 VWF
4 cytokine-mediated signaling pathway GO:0019221 9.8 IL12B IL6 MMP3 MMP9 TNF VCAM1
5 defense response to Gram-positive bacterium GO:0050830 9.77 CRP IL6 TNF
6 positive regulation of interferon-gamma production GO:0032729 9.67 HLA-DPB1 IL12B TNF
7 positive regulation of T cell proliferation GO:0042102 9.67 HLA-DPB1 IL12B IL6 VCAM1
8 positive regulation of T cell mediated cytotoxicity GO:0001916 9.65 HLA-A HLA-B IL12B
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.59 HLA-DPB1 HLA-DRB1
10 T-helper 1 type immune response GO:0042088 9.58 HLA-DRB1 IL12B
11 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.58 HLA-A HLA-B
12 leukocyte tethering or rolling GO:0050901 9.58 SELE TNF VCAM1
13 opsonization GO:0008228 9.57 CRP PTX3
14 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.56 HLA-A HLA-B
15 positive regulation of neuroinflammatory response GO:0150078 9.55 IL6 TNF
16 protection from natural killer cell mediated cytotoxicity GO:0042270 9.52 HLA-A HLA-B
17 regulation of neuroinflammatory response GO:0150077 9.51 MMP3 MMP9
18 antigen processing and presentation GO:0019882 9.46 HLA-A HLA-B HLA-DPB1 HLA-DRB1
19 negative regulation of lipid storage GO:0010888 9.43 CRP IL6 TNF
20 interferon-gamma-mediated signaling pathway GO:0060333 9.35 HLA-A HLA-B HLA-DPB1 HLA-DRB1 VCAM1
21 immune response GO:0006955 9.23 FCGR3A HLA-A HLA-B HLA-DPB1 HLA-DRB1 IL6

Molecular functions related to Takayasu Arteritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 9.32 FCGR2A FCGR3A
2 virion binding GO:0046790 9.26 CRP PTX3
3 complement component C1q binding GO:0001849 9.16 CRP PTX3
4 beta-2-microglobulin binding GO:0030881 8.96 HLA-A MICA
5 peptide antigen binding GO:0042605 8.92 HLA-A HLA-B HLA-DPB1 HLA-DRB1

Sources for Takayasu Arteritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....