TA
MCID: TKY002
MIFTS: 62

Takayasu Arteritis (TA)

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Fetal diseases, Nephrological diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Takayasu Arteritis

MalaCards integrated aliases for Takayasu Arteritis:

Name: Takayasu Arteritis 56 12 74 52 58 43 17 71
Aortic Arch Syndrome 56 12 52
Young Female Arteritis 56 52
Aortic Arch Syndromes 43 71
Takayasu's Arteritis 12 15
Aortic Arches Defect 74 52
Idiopathic Aortitis 12 71
Aortic Arch Defects 52 58
Pulseless Disease 56 52
Aortic Arch Arteritis 12
Takayasu's Disease 12
Takayasu Disease 52
Ta 52

Characteristics:

Orphanet epidemiological data:

58
takayasu arteritis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),1-9/100000 (Japan),1-9/1000000 (Sweden),1-9/1000000 (United Kingdom); Age of onset: Adolescent,Adult; Age of death: adult;
aortic arch defects
Inheritance: Not applicable; Age of onset: Childhood;

OMIM:

56
Inheritance:
? autosomal recessive vs. autoimmune


HPO:

31
takayasu arteritis:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 58  
Rare circulatory system diseases
Rare cardiac malformations
Rare renal diseases
Rare respiratory diseases
Rare systemic and rhumatological diseases
Developmental anomalies during embryogenesis


Summaries for Takayasu Arteritis

NIH Rare Diseases : 52 Takayasu arteritis is a condition that causes inflammation of the main blood vessel that carries blood from the heart to the rest of the body (aorta ) and its associated branched blood vessels. As a result of the inflammation, the blood vessel walls become thick and make it difficult for blood to flow. Over time, impaired blood flow causes damage to the heart and various other organs of the body. Although the cause remains unknown, Takayasu arteritis appears to be an autoimmune condition, in which cells that fight infection and disease are wrongly targeted against the body's own tissues .

MalaCards based summary : Takayasu Arteritis, also known as aortic arch syndrome, is related to vasculitis and aortic aneurysm. An important gene associated with Takayasu Arteritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Methotrexate and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related phenotypes are fatigue and fever

Disease Ontology : 12 A vasculitis that involves inflammation of the aorta that carries blood from the heart to the rest of the body.

Wikipedia : 74 Interrupted aortic arch is a very rare heart defect (affecting 3 per million live births) in which the... more...

More information from OMIM: 207600

Related Diseases for Takayasu Arteritis

Diseases related to Takayasu Arteritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 956)
# Related Disease Score Top Affiliating Genes
1 vasculitis 32.9 VCAM1 TNF SELE PTX3 IL6 ICAM1
2 aortic aneurysm 31.8 MMP9 MMP3 IL6 CRP
3 colitis 31.6 TNF IL6 IL1B HLA-DRB1
4 coronary stenosis 31.5 IL6 ICAM1 CRP
5 congestive heart failure 31.5 TNF IL6 IL1B CRP
6 aortitis 31.5 TNF IL6 IL1B CRP CD40LG
7 intermediate coronary syndrome 31.4 VCAM1 IL6 CRP
8 aortic aneurysm, familial abdominal, 1 31.4 MMP9 MMP3 IL6 CRP
9 ulcerative colitis 31.4 TNF IL6 IL1B ICAM1 HLA-DRB1 CRP
10 intermittent claudication 31.3 IL6 CRP CD40LG
11 thyroiditis 31.3 TNF PTPN22 IL6
12 crohn's disease 31.2 TNF PTPN22 IL6 IL1B HLA-DRB1 CRP
13 pyoderma 31.2 TNF MMP9 IL1B CRP CD40LG
14 osteomyelitis 31.2 TNF IL6 IL1B
15 purpura 31.1 TNF IL6 CRP CD40LG
16 spondylitis 31.1 TNF MICA IL6 HLA-B CRP
17 uveitis 31.1 TNF IL6 IL1B ICAM1 HLA-B
18 limb ischemia 31.1 TNF SELE MMP9 IL6 ICAM1
19 antiphospholipid syndrome 31.1 VCAM1 TNF SELE CRP CD40LG
20 glomerulonephritis 31.1 VCAM1 IL1B ICAM1 CD40LG
21 optic nerve disease 31.0 TNF IL6 IL1B CRP CD40LG
22 acute myocardial infarction 31.0 TNF SELE PTX3 MMP9 IL6 CRP
23 pericardial effusion 31.0 IL6 CRP CD40LG
24 neuritis 31.0 TNF MMP9 IL6 IL1B
25 spondyloarthropathy 1 31.0 TNF MMP3 HLA-B CRP CD40LG
26 sarcoidosis 1 31.0 TNF IL1B ICAM1 HLA-DRB1 CRP CD40LG
27 placenta disease 31.0 TNF IL6 IL1B CRP
28 infective endocarditis 31.0 TNF IL6 FCGR2A CRP
29 familial mediterranean fever 31.0 TNF IL6 IL1B CRP
30 carotid stenosis 31.0 VCAM1 TNF SELE MMP9 ICAM1 CRP
31 pericarditis 31.0 TNF IL6 IL1B CRP CD40LG
32 endocarditis 31.0 VCAM1 TNF IL6 FCGR2A CRP
33 scleritis 30.9 TNF SELE PTPN22 MMP9 CRP
34 polyarteritis nodosa 30.9 VCAM1 SELE IL6 ICAM1 HLA-DRB1 CRP
35 granulomatosis with polyangiitis 30.9 TNF SELE PTPN22 CRP CD40LG
36 brucellosis 30.9 TNF MICA IL6 CRP CD40LG
37 microscopic polyangiitis 30.9 TNF HLA-DRB1 FCGR2A
38 subacute thyroiditis 30.9 TNF IL6 IL1B CRP
39 stroke, ischemic 30.9 TNF MMP9 IL6 IL1B CRP
40 pulmonary tuberculosis 30.9 TNF IL6 IL1B IL12B HLA-DRB1 CRP
41 oligoarticular juvenile idiopathic arthritis 30.8 TNF PTPN22 HLA-DRB1
42 optic neuritis 30.8 VCAM1 TNF IL6 IL1B HLA-DRB1
43 microscopic colitis 30.8 TNF IL6 HLA-DRB1
44 spinal cord injury 30.8 TNF MMP9 IL6
45 retinal ischemia 30.8 TNF IL1B ICAM1
46 exanthem 30.8 TNF IL6 IL1B CRP CD40LG
47 pulmonary edema 30.8 TNF IL1B ICAM1 CRP
48 granulomatous hepatitis 30.8 TNF CRP CD40LG
49 abdominal tuberculosis 30.8 TNF CRP CD40LG
50 polyclonal hypergammaglobulinemia 30.8 IL6 CRP CD40LG

Graphical network of the top 20 diseases related to Takayasu Arteritis:



Diseases related to Takayasu Arteritis

Symptoms & Phenotypes for Takayasu Arteritis

Human phenotypes related to Takayasu Arteritis:

58 31 (show all 49)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 hyperhidrosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000975
4 weight loss 58 31 hallmark (90%) Very frequent (99-80%) HP:0001824
5 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482
6 hypertensive crisis 58 31 hallmark (90%) Very frequent (99-80%) HP:0100735
7 vasculitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002633
8 abnormal aortic arch morphology 31 hallmark (90%) HP:0012303
9 arthritis 58 31 frequent (33%) Frequent (79-30%) HP:0001369
10 muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0001324
11 hypertrophic cardiomyopathy 58 31 frequent (33%) Frequent (79-30%) HP:0001639
12 anemia 58 31 frequent (33%) Frequent (79-30%) HP:0001903
13 skin ulcer 58 31 frequent (33%) Frequent (79-30%) HP:0200042
14 abnormal aortic valve morphology 58 31 frequent (33%) Frequent (79-30%) HP:0001646
15 myocardial infarction 58 31 frequent (33%) Frequent (79-30%) HP:0001658
16 pulmonary arterial hypertension 58 31 frequent (33%) Frequent (79-30%) HP:0002092
17 abnormal pattern of respiration 58 31 frequent (33%) Frequent (79-30%) HP:0002793
18 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
19 chest pain 58 31 frequent (33%) Frequent (79-30%) HP:0100749
20 gangrene 58 31 frequent (33%) Frequent (79-30%) HP:0100758
21 respiratory insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0002093
22 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
23 apnea 58 31 frequent (33%) Frequent (79-30%) HP:0002104
24 migraine 58 31 frequent (33%) Frequent (79-30%) HP:0002076
25 inflammatory abnormality of the eye 58 31 frequent (33%) Frequent (79-30%) HP:0100533
26 ascending tubular aorta aneurysm 31 frequent (33%) HP:0004970
27 seizure 31 frequent (33%) HP:0001250
28 recurrent respiratory infections 58 31 occasional (7.5%) Occasional (29-5%) HP:0002205
29 neurological speech impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0002167
30 reduced consciousness/confusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0004372
31 feeding difficulties in infancy 58 31 occasional (7.5%) Occasional (29-5%) HP:0008872
32 retinopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0000488
33 arthralgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002829
34 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
35 asthma 58 31 occasional (7.5%) Occasional (29-5%) HP:0002099
36 cerebral ischemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002637
37 gastrointestinal infarctions 58 31 occasional (7.5%) Occasional (29-5%) HP:0005244
38 amaurosis fugax 58 31 occasional (7.5%) Occasional (29-5%) HP:0100576
39 abnormal endocardium morphology 31 occasional (7.5%) HP:0004306
40 seizures 58 Frequent (79-30%)
41 abnormal heart valve morphology 58 Very frequent (99-80%)
42 hypertension 58 Frequent (79-30%)
43 abnormality of the endocardium 58 Occasional (29-5%)
44 dilatation of the ascending aorta 58 Frequent (79-30%)
45 abnormality of the aortic arch 58 Very frequent (99-80%)
46 arterial stenosis 58 Very frequent (99-80%)
47 aneurysm 58 Very frequent (99-80%)
48 increased inflammatory response 58 Frequent (79-30%)
49 arteritis 31 HP:0012089

Symptoms via clinical synopsis from OMIM:

56
Vascular:
arteritis, major aortic branches

Limbs:
decreased pulses, upper limbs

Clinical features from OMIM:

207600

MGI Mouse Phenotypes related to Takayasu Arteritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 CD40LG CRP ICAM1 IL1B IL6 MMP9
2 hematopoietic system MP:0005397 9.8 CD40LG FCGR2A ICAM1 IL12B IL1B IL6
3 immune system MP:0005387 9.5 CD40LG CRP FCGR2A ICAM1 IL12B IL1B

Drugs & Therapeutics for Takayasu Arteritis

Drugs for Takayasu Arteritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
2
Adalimumab Approved Phase 4 331731-18-1 16219006
3
leucovorin Approved Phase 4 58-05-9 6006 143
4
Tofacitinib Approved, Investigational Phase 4 477600-75-2
5
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
6 Dermatologic Agents Phase 4
7 Antirheumatic Agents Phase 4
8 Immunologic Factors Phase 4
9 Immunosuppressive Agents Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Protein Kinase Inhibitors Phase 4
12 Immunoglobulins Phase 4
13 Antibodies Phase 4
14 Antimetabolites Phase 4
15 Immunoglobulins, Intravenous Phase 4
16 Vitamin B Complex Phase 4
17 Folic Acid Antagonists Phase 4
18 Folate Phase 4
19 Vitamin B9 Phase 4
20 Omega 3 Fatty Acid Phase 4
21
Mycophenolic acid Approved Phase 3 24280-93-1 446541
22
Azathioprine Approved Phase 3 446-86-6 2265
23
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
24
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
25
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
26 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
27
Upadacitinib Approved, Investigational Phase 3 1310726-60-3 58557659
28
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
29
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
30
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
31
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
32
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
33 Methylprednisolone Acetate Phase 3
34 Janus Kinase Inhibitors Phase 3
35 Albumin-Bound Paclitaxel Phase 3
36 Tubulin Modulators Phase 3
37 Antimitotic Agents Phase 3
38 Hormones Phase 2, Phase 3
39 Antineoplastic Agents, Hormonal Phase 2, Phase 3
40 Hormone Antagonists Phase 2, Phase 3
41 glucocorticoids Phase 2, Phase 3
42 Alkylating Agents Phase 2, Phase 3
43
Infliximab Approved Phase 2 170277-31-3
44
Abatacept Approved Phase 2 332348-12-6 10237
45
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
46
Ethanol Approved Phase 2 64-17-5 702
47
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
48 Gastrointestinal Agents Phase 2
49 Narcotics Phase 2
50 Narcotic Antagonists Phase 2

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 A Pilot Study in the Treatment of Severe Patients With Takayasu Arteritis With Tocilizumab and Adalimumab, Based on ECTA Cohort Recruiting NCT04300686 Phase 4
2 Randomized Open-label Study in Mild and Moderate Patients With Takayasu Arteritis Between Methotrexate and Tofacitinib Based on the ECTA Cohort. Recruiting NCT04299971 Phase 4 Methotrexate Tablets;Tofacitinib tablet
3 Protocol for a Randomized, Placebo-Controlled, Double-Blinded Trial to Study the Effects of Supplementary Omega-3 Fatty Acids on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
4 Comparison of the Efficacy of Mycophenolate Mofetil Combined With Methotrexate and Cyclophosphamide for the Treatment of Takayasu's Arteritis Unknown status NCT03096275 Phase 3 MMF;CYC;Glucocorticoids;MTX;AZA
5 Efficacy and Tolerance of First-line Treatment With Tocilizumab in Active Takayasu Arteritis French Prospective Multicenter Study Unknown status NCT02101333 Phase 3 Tocilizumab
6 A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Upadacitinib in Subjects With Takayasu Arteritis (SELECT-Takayasu) Recruiting NCT04161898 Phase 3 Upadacitinib;Placebo for Upadacitinib;Prednisolone
7 Comparison of Drug-eluting Balloon and Plain Balloon for Treatment of Non-atherosclerotic Renal Artery Stenosis: a Randomized Controlled Study Recruiting NCT04366596 Phase 3
8 Does Inactive Takayasu Arteritis(NIH Criteria) Need Anti-inflammatory Treatment? Not yet recruiting NCT03550781 Phase 2, Phase 3 Prednisone, cyclophosphamide
9 Anti-tumor Necrosis Factor Therapy Effect on Takayasu Arteritis Unknown status NCT02457585 Phase 2 remicade (anti tumor necrosis factor inhibitor)
10 Concurrent Pilot Studies in Giant Cell Arteritis and Takayasu's Arteritis to Examine the Safety, Efficacy, and Immunologic Effects of Abatacept (CTLA4-Ig) in Large Vessel Vasculitis Completed NCT00556439 Phase 2 Abatacept;Placebo
11 An Open Trial of the Efficacy of Glucocorticoids and Methotrexate (MTX) in the Treatment of Systemic Vasculitis Completed NCT00001256 Phase 2 prednisone and methotrexate
12 Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis Recruiting NCT03482479 Phase 2 Naltrexone Hydrochloride
13 Induction of Regulatory t Cells by Low Dose IL2 in Autoimmune and Inflammatory Diseases: a Transnosographic Approach Recruiting NCT01988506 Phase 2 Interleukin 2
14 Comparison of the Efficacy and Safety of Leflunomide Versus Placebo Combine With the Basic Prednisone Therapy in Patients With Active Phase of Takayasu's Arteritis: a Randomized Controlled Double-blinded Trial Unknown status NCT02981979 Leflunomide 10mg Tab;Prednisone Acetate;Placebos
15 Effects of Exercise Training in Primary Sjogren´s Syndrome, Myositis and Takayasu's Arteritis Unknown status NCT01501019
16 Exercise in Juvenile Takayasu Disease: a Randomized Controlled Trial Unknown status NCT03494062
17 A Prospective Observational Study of Infliximab Biosimilar in the Treatment of Takayasu's Arteritis Resistant to Corticosteroids and Conventional Immune-suppressive Treatments Unknown status NCT03192878 Infliximab
18 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
19 Chronic Childhood Vasculitis: Characterizing the Individual Rare Diseases to Improve Patient Outcomes Unknown status NCT02006134
20 ACR/EULAR Endorsed Study to Develop New Diagnostic and Classification Criteria for Primary Systemic Vasculitis Unknown status NCT01066208
21 A Prospective Study of Using Parenchymal Blood Volume(PBV) for Endovascular Treatment of Renal Arterial Stenosis Unknown status NCT03252639
22 Pulmonary Artery Involvement in Takayasu's Arteritis: a Retrospective Study in China Completed NCT03189602
23 Contrast Enhanced Ultrasound for Assessment of Carotid Artery Neovascularization as a Marker of Disease Activity in Takayasu's Arteritis and Giant Cell Arteritis Completed NCT01795456
24 VCRC Imaging Protocol for Magnetic Resonance and Positron Emission Tomography in Large-vessel Vasculitis (Takayasu's Arteritis):Development as Clinical Trial Outcome Measures Completed NCT00744952
25 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
26 Impact and Utility of Positron Emission Tomography (PET) for the Assessment of Inflammatory Activity Arteritis Versus Clinical Score and Laboratory Values in Takayasu Arteritis: a Cohort Study Completed NCT01532167
27 VCRC Validation of Patient-Reported Diagnostic Data Completed NCT02190942
28 Educational Needs of Patients With Systemic Vasculitis- an International Survey Completed NCT02190929
29 Illness Perception, Fatigue, and Function in Systemic Vasculitis (The VCRC Vasculitis Perception (VIP) Study) Completed NCT02190916
30 VCRC Longitudinal Protocol for Aortitis Completed NCT03022331
31 The Long-term Success of Cardiovascular Surgery in Takayasu Arteritis. 30 Years of Experience in Mexico, Beyond Forefront Techniques Completed NCT03654222
32 The Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
33 The Biodistribution of 18F-Clofarabine in Patients With Autoimmune and Inflammatory Diseases Completed NCT02925351
34 Impact of Vasculitis on Employment and Income. An Online Survey of Participants in the VCRC Patient Contact Registry Completed NCT02476292
35 Evaluation of Yellow Fever Vaccine in Patients With Rheumatic Diseases Under Low Immunosuppression Level and Residing in a Risk Area Completed NCT03430388
36 A Head-to-Head Comparison of Color Doppler Ultrasonography (CDUS) and Magnetic Resonance Angiography (MRA) in Patients With Systemic Large Vessel Vasculitis (sLVV) - A Cross Sectional Study Completed NCT02042092
37 A Registry Study on Biomarkers of Takayasu's Arteritis Recruiting NCT03372980
38 Registration Study of Takayasu's Arteritis in China Recruiting NCT03199183
39 Aerobic Capacity and Strength Exercise in Takayasu's Arteritis: Impact on Clinical, Laboratory and Vascular Parameters Recruiting NCT03750929
40 Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis Recruiting NCT02257866
41 Takayasu Arteritis Activity Evaluation by Ultrafast Ultrasound Imaging Recruiting NCT03956394
42 Determining the Association Between Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity Recruiting NCT03941184
43 The Cohort Study of East Chinese Takayasu's Arteritis (ECTA-cohort Study) Recruiting NCT03893136 Leflunomide
44 The PET Imaging of Giant Cell and Takayasu Arteritis Study Recruiting NCT04071691
45 Observational Multicenter Study of Refractory and/or Relapsing Takayasu Arteritis START: Study of Refractory and/or Relapsing TAkayasu aRTeritis Recruiting NCT03543527
46 China Takayasu Arteritis Registry (CTA Registry) Recruiting NCT02964364
47 The Vasculitis Pregnancy Registry (V-PREG) Recruiting NCT02593565
48 VCRC Tissue Biorepository Collection Protocol Recruiting NCT02967068
49 Aortitis and Retroperitoneal Fibrosis: Evaluation of Diagnostic Criteria Recruiting NCT03133949
50 Clinical Characteristics of Allergy, Autoimmune and Rheumatic Diseases: A Ten Year Retrospective Study Recruiting NCT01611636

Search NIH Clinical Center for Takayasu Arteritis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Alprostadil

Cochrane evidence based reviews: takayasu arteritis

Genetic Tests for Takayasu Arteritis

Anatomical Context for Takayasu Arteritis

MalaCards organs/tissues related to Takayasu Arteritis:

40
Heart, Endothelial, Kidney, T Cells, Eye, Bone, Lung

Publications for Takayasu Arteritis

Articles related to Takayasu Arteritis:

(show top 50) (show all 2063)
# Title Authors PMID Year
1
Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. 61 56
23830516 2013
2
Identification of multiple genetic susceptibility loci in Takayasu arteritis. 56 61
23830517 2013
3
Matrix metalloproteinases as novel disease markers in Takayasu arteritis. 56 61
12952836 2003
4
DNA typing of HLA-B gene in Takayasu's arteritis. 56 61
7903491 1993
5
Takayasu's disease in twin sisters. 56
6145807 1984
6
HLA-DR MT and MB antigens in Takayasu disease. 56
6134351 1983
7
Association between Takayasu's arteritis and a B-cell alloantigen in North Americans. 56
6977091 1982
8
HL-A antigens in Takayasu's disease. 56
36742 1979
9
Association between Takayasu disease and HLA-DHO. 56
91228 1979
10
HLA-Bw52 in Takayasu disease. 56
31708 1978
11
Takayasu's disease in twin sisters. Possible genetic factors. 56
25719 1978
12
TAKAYASU'S ARTERITIS. REPORT OF FIVE CASES WITH IMMUNOLOGIC STUDIES. 56
14176969 1964
13
Clinical Characteristics and Long-Term Outcomes of Midaortic Syndrome. 61
31923594 2020
14
Takayasu arteritis and pregnancy. 61
32440786 2020
15
A case of Takayasu arteritis complicated by refractory ulcerative colitis successfully treated with tofacitinib. 61
31776552 2020
16
Surgical Treatment in Patients With Aortic Regurgitation Due to Takayasu Arteritis. 61
31756318 2020
17
An Observational Study of Sex Differences in Takayasu Arteritis in China: Implications for Worldwide Regional Differences. 61
31863951 2020
18
A retrospective cohort study to assess PET-CT findings and clinical outcomes in Takayasu arteritis: does 18F-fluorodeoxyglucose uptake in arteries predict relapses? 61
32200427 2020
19
Tocilizumab monotherapy for large vessel vasculitis: results of 104-week treatment of a prospective, single-centre, open study. 61
31665468 2020
20
Takayasu's Arteritis Presenting Atypically in a Female Nigerian. 61
32476124 2020
21
Drug retention and discontinuation reasons between seven biologics in patients with Takayasu arteritis. 61
32088012 2020
22
Paraneoplastic small vessel vasculitis and Takayasu arteritis associated with polycythemia rubra vera. 61
32538551 2020
23
Novel Approach to Imaging Active Takayasu Arteritis Using Somatostatin Receptor Positron Emission Tomography/Magnetic Resonance Imaging. 61
32460529 2020
24
[Renovascular hypertension secondary to Takayasu arteritis]. 61
32564975 2020
25
Carotid Artery Dissection: A Rare Presenting Manifestation of Takayasu Arteritis. 61
32558679 2020
26
Abdominal Pain in a Patient With Takayasu Arteritis. 61
32221159 2020
27
Axillofemoral bypass to improve congestive heart failure for atypical aortic coarctation complicating Takayasu arteritis. 61
32558325 2020
28
Intravascular ultrasound imaging of isolated and non aorto-ostial coronary Takayasu arteritis: a case report. 61
32487208 2020
29
Translating IL-6 biology into effective treatments. 61
32327746 2020
30
Is Takayasu arteritis the result of a Mycobacterium tuberculosis infection? The use of TNF inhibitors may be the proof-of-concept to demonstrate that this association is epiphenomenal. 61
32198554 2020
31
Antineoplastic Drug-induced Aortitis: An Unraveled Adverse Effect Using the World Health Organization Pharmacovigilance Database. 61
32482651 2020
32
18F-FDG PET/CT plays a unique role in the management of Takayasu arteritis patients with atypical manifestations. 61
32562071 2020
33
Myocardial Infarction Due to Takayasu Arteritis in Adults: Look Out for Multivascular Involvement and Signs of Systemic Inflammation. 61
32404289 2020
34
Involvement of the pulmonary arteries in patients with Takayasu arteritis: a prospective study from a single centre in China. 61
32503678 2020
35
X-linked inhibitor of apoptosis protein deficiency complicated with Crohn's disease-like enterocolitis and Takayasu arteritis: A case report. 61
32540394 2020
36
Isolated Oculomotor Nerve Palsy in Takayasu Arteritis-A Rare Complication. 61
32453215 2020
37
Coronary Ostial Patch Angioplasty with Femoral Artery in Takayasu Arteritis. 61
32376353 2020
38
Typical angina in a patient with Takayasu arteritis. 61
31364802 2020
39
Coronary artery involvements in Takayasu arteritis: systematic review of reports. 61
32430746 2020
40
Pregnancy and Takayasu arteritis: case-based review. 61
31858208 2020
41
[Treatment of Takayasu arteritis]. 61
32430564 2020
42
Takayasu Arteritis: A Case Series of Unusual Presentations and Complications and a Review of Management. 61
32453213 2020
43
Biologic therapy in supra-aortic Takayasu arteritis can improve symptoms of cerebral ischaemia without surgical intervention. 61
32348517 2020
44
Response to: 'JAK inhibitors as promising agents for refractory Takayasu arteritis' by Watanabe. 61
32381559 2020
45
Numano type V Takayasu arteritis patients are more prone to have coronary artery involvement. 61
32424657 2020
46
Clinical Outcome of Extraanatomic Bypass for Midaortic Syndrome Caused by Takayasu Arteritis. 61
31557481 2020
47
Association between plasma fibroblast growth factor 23 and left ventricular mass index in patients with Takayasu arteritis. 61
31897962 2020
48
Characteristics and medium-term outcomes of Takayasu arteritis-related renal artery stenosis: analysis of a large Chinese cohor. 61
32358160 2020
49
Comparing the effects of different management strategies on long-term outcomes for significant coronary stenosis in patients with Takayasu arteritis. 61
32115273 2020
50
Association between the antineutrophil cytoplasmic antibody and late coronary arterial occlusive disease in patients with Takayasu arteritis. 61
32482328 2020

Variations for Takayasu Arteritis

Expression for Takayasu Arteritis

Search GEO for disease gene expression data for Takayasu Arteritis.

Pathways for Takayasu Arteritis

Pathways related to Takayasu Arteritis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 VCAM1 TNF PTX3 PTPN22 MMP9 MMP3
2
Show member pathways
13.49 VCAM1 PTPN22 MICA LILRB3 ICAM1 HLA-DRB1
3
Show member pathways
13.42 VCAM1 TNF MMP9 MMP3 IL6 IL1B
4
Show member pathways
12.98 TNF MICA IL6 IL1B ICAM1 HLA-B
5
Show member pathways
12.91 TNF MICA IL6 IL1B IL12B ICAM1
6
Show member pathways
12.87 TNF IL6 IL1B IL12B ICAM1 HLA-DRB1
7 12.85 TNF IL6 IL1B IL12B HLA-DRB1 HLA-B
8
Show member pathways
12.64 TNF IL6 IL1B IL12B HLA-DRB1
9 12.61 VCAM1 TNF PTPN22 IL1B CD40LG
10
Show member pathways
12.56 TNF MICA ICAM1 HLA-B FCGR3A
11 12.39 TNF IL6 ICAM1 HLA-DRB1 HLA-B
12
Show member pathways
12.38 TNF MMP9 MMP3 IL6 IL1B
13
Show member pathways
12.37 TNF IL6 IL1B ICAM1 CRP
14
Show member pathways
12.34 TNF IL1B IL12B HLA-DRB1 FCGR3A FCGR2A
15
Show member pathways
12.31 TNF IL6 IL1B IL12B HLA-B
16 12.3 TNF IL6 IL1B FCGR2A
17 12.29 TNF IL6 IL1B IL12B HLA-DRB1 FCGR3A
18
Show member pathways
12.26 TNF IL6 IL1B IL12B
19 12.24 VCAM1 SELE ICAM1 HLA-DRB1 HLA-B CD40LG
20 12.2 VCAM1 TNF SELE MMP9 IL1B ICAM1
21 12.19 HLA-DRB1 HLA-B FCGR3A FCGR2A
22 12.12 TNF LILRB3 IL1B FCGR3A FCGR2A
23 12.11 VCAM1 MICA LILRB3 ICAM1 HLA-B FCGR3A
24 12.08 VCAM1 MMP9 MMP3 ICAM1
25 12.03 TNF MMP9 LILRB3 IL6 IL1B ICAM1
26 12.02 VCAM1 TNF IL1B ICAM1 CD40LG
27 12.02 VCAM1 TNF SELE IL6 IL1B ICAM1
28
Show member pathways
12 TNF IL6 IL1B IL12B
29 11.98 TNF IL6 IL1B IL12B
30 11.98 TNF MMP3 IL6 IL1B ICAM1 HLA-DRB1
31 11.98 VCAM1 TNF MMP9 MMP3 IL6 IL1B
32 11.96 TNF IL6 IL1B HLA-DRB1
33 11.95 ICAM1 HLA-DRB1 FCGR3A FCGR2A
34 11.91 VCAM1 TNF SELE MMP9 MMP3 IL6
35 11.81 SELE IL6 ICAM1
36 11.81 TNF IL6 IL1B IL12B
37 11.77 TNF IL6 IL1B
38 11.73 TNF PTX3 MMP9 IL6 IL1B IL12B
39 11.68 TNF IL6 IL1B IL12B
40 11.65 TNF IL6 IL1B IL12B ICAM1
41 11.6 TNF MMP9 IL6 ICAM1
42 11.57 TNF IL1B IL12B
43 11.57 TNF IL1B IL12B
44 11.54 TNF IL6 IL1B
45 11.54 VCAM1 SELE ICAM1
46 11.46 SELE MMP9 MMP3
47 11.44 IL1B ICAM1 HLA-B
48 11.41 TNF IL6 IL1B
49 11.4 TNF IL6 IL1B IL12B
50 11.4 VCAM1 TNF SELE IL6 IL1B ICAM1

GO Terms for Takayasu Arteritis

Cellular components related to Takayasu Arteritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TNF PTX3 MMP9 MMP3 IL6 IL1B
2 integral component of plasma membrane GO:0005887 9.9 VCAM1 TNF SELE MICA LILRB3 ICAM1
3 cell surface GO:0009986 9.86 VCAM1 TNF MICA IL12B ICAM1 HLA-DRB1
4 external side of plasma membrane GO:0009897 9.56 VCAM1 TNF MICA IL12B ICAM1 HLA-DRB1
5 extracellular space GO:0005615 9.47 VCAM1 TNF SELE PTX3 MMP9 MMP3

Biological processes related to Takayasu Arteritis according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.08 TNF PTPN22 IL6 IL1B CRP
2 neutrophil degranulation GO:0043312 10.07 PTX3 MMP9 LILRB3 HLA-B FCGR2A
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 TNF PTPN22 ICAM1 HLA-DRB1
4 leukocyte migration GO:0050900 9.96 TNF SELE IL1B ICAM1
5 positive regulation of protein phosphorylation GO:0001934 9.95 TNF MMP9 IL1B HLA-DRB1
6 response to lipopolysaccharide GO:0032496 9.94 SELE PTPN22 IL1B ICAM1
7 cellular response to lipopolysaccharide GO:0071222 9.93 TNF IL6 IL1B IL12B ICAM1
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TNF IL6 IL1B ICAM1 CD40LG
9 inflammatory response GO:0006954 9.91 TNF SELE PTX3 IL6 IL1B CRP
10 extracellular matrix organization GO:0030198 9.88 VCAM1 TNF PTX3 MMP9 MMP3 ICAM1
11 immune response GO:0006955 9.86 TNF MICA IL6 IL1B HLA-DRB1 HLA-B
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 TNF IL6 IL12B
13 interferon-gamma-mediated signaling pathway GO:0060333 9.85 VCAM1 ICAM1 HLA-DRB1 HLA-B
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TNF IL1B IL12B
15 positive regulation of interleukin-6 production GO:0032755 9.82 TNF IL6 IL1B
16 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.81 VCAM1 SELE ICAM1
17 positive regulation of phagocytosis GO:0050766 9.79 TNF PTX3 IL1B
18 positive regulation of interferon-gamma production GO:0032729 9.79 TNF IL1B IL12B
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TNF PTPN22 IL1B
20 negative regulation of neurogenesis GO:0050768 9.75 TNF IL6 IL1B
21 positive regulation of glial cell proliferation GO:0060252 9.74 TNF IL6 IL1B
22 leukocyte tethering or rolling GO:0050901 9.73 VCAM1 TNF SELE
23 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 TNF PTX3 IL1B ICAM1
24 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.7 TNF IL6 ICAM1
25 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 IL1B IL12B
26 T-helper 1 type immune response GO:0042088 9.68 IL12B HLA-DRB1
27 opsonization GO:0008228 9.67 PTX3 CRP
28 positive regulation of neuroinflammatory response GO:0150078 9.67 TNF IL6 IL1B
29 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
30 regulation of neuroinflammatory response GO:0150077 9.65 MMP9 MMP3 IL6
31 regulation of immunoglobulin secretion GO:0051023 9.63 TNF CD40LG
32 positive regulation of fever generation GO:0031622 9.63 TNF IL1B
33 negative regulation of lipid storage GO:0010888 9.63 TNF IL6 CRP
34 membrane to membrane docking GO:0022614 9.62 VCAM1 ICAM1
35 leukocyte cell-cell adhesion GO:0007159 9.62 VCAM1 SELE ICAM1 CD40LG
36 negative regulation by host of viral process GO:0044793 9.61 PTX3 CRP
37 sequestering of triglyceride GO:0030730 9.6 TNF IL1B
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 TNF IL1B
39 positive regulation of T cell proliferation GO:0042102 9.55 VCAM1 IL6 IL1B IL12B CD40LG
40 regulation of immune response GO:0050776 9.5 VCAM1 MICA ICAM1 HLA-B FCGR3A FCGR2A
41 cytokine-mediated signaling pathway GO:0019221 9.23 VCAM1 TNF MMP9 MMP3 IL6 IL1B

Molecular functions related to Takayasu Arteritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.21 TNF SELE PTX3 PTPN22 MMP9 MMP3
2 transmembrane signaling receptor activity GO:0004888 9.55 SELE LILRB3 ICAM1 FCGR3A FCGR2A
3 IgG binding GO:0019864 9.37 FCGR3A FCGR2A
4 complement component C1q binding GO:0001849 9.32 PTX3 CRP
5 integrin binding GO:0005178 9.26 VCAM1 IL1B ICAM1 CD40LG
6 cytokine activity GO:0005125 9.02 TNF IL6 IL1B IL12B CD40LG

Sources for Takayasu Arteritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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