MCID: TLL001
MIFTS: 28

Tall Cell Variant Papillary Carcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Tall Cell Variant Papillary Carcinoma

MalaCards integrated aliases for Tall Cell Variant Papillary Carcinoma:

Name: Tall Cell Variant Papillary Carcinoma 12 15
Tall Cell Variant Thyroid Gland Papillary Carcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7089
NCIt 50 C35558
UMLS 70 C1336695

Summaries for Tall Cell Variant Papillary Carcinoma

MalaCards based summary : Tall Cell Variant Papillary Carcinoma, also known as tall cell variant thyroid gland papillary carcinoma, is related to thyroid cancer, nonmedullary, 1 and hypothyroidism. An important gene associated with Tall Cell Variant Papillary Carcinoma is MET (MET Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Calcium signaling pathway and Pathways in cancer. Affiliated tissues include thyroid, lung and skin, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Tall Cell Variant Papillary Carcinoma

Diseases related to Tall Cell Variant Papillary Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 thyroid cancer, nonmedullary, 1 30.4 NKX2-1 BRAF
2 hypothyroidism 29.3 TG RET NKX2-1 LGALS3 BRAF
3 thyroid carcinoma 29.3 TG RET NTRK1 NKX2-1 LGALS3 BRAF
4 papillary carcinoma 28.6 TG RET NTRK1 NKX2-1 MET LGALS3
5 thyroid sarcoma 10.2 TG TERT
6 carotid body cancer 10.2 TG NKX2-1
7 olfactory neuroblastoma 10.2 NTRK1 NKX2-1
8 athyreosis 10.2 TG NKX2-1
9 ectopic thymus 10.2 TG NKX2-1
10 isthmus cancer 10.2 TG LGALS3
11 colloid adenoma 10.1 TG LGALS3
12 multicentric papillary thyroid carcinoma 10.1 TG RET
13 syringocystadenoma papilliferum 10.1 KRT19 BRAF
14 newborn respiratory distress syndrome 10.1 NKX2-1 BRAF
15 atypical follicular adenoma 10.1 TG RET
16 hypothyroidism, congenital, nongoitrous, 2 10.1 TG NKX2-1
17 adenofibroma 10.1 KRT19 BRAF
18 thyroid tumor 10.1 RET BRAF
19 mucinous bronchioloalveolar adenocarcinoma 10.1 NKX2-1 LGALS3
20 mixed fibrolamellar hepatocellular carcinoma 10.1 TERT KRT19
21 multiple mucosal neuroma 10.1 RET NTRK1
22 acral lentiginous melanoma 10.1 TERT MET BRAF
23 sarcomatous intrahepatic cholangiocarcinoma 10.1 NKX2-1 KRT19
24 cutaneous adenocystic carcinoma 10.1 NKX2-1 KRT19
25 colon neuroendocrine neoplasm 10.0 NKX2-1 KRT19
26 liver benign neoplasm 10.0 TERT KRT19
27 diffuse astrocytoma 10.0 TERT BRAF
28 autonomic nervous system benign neoplasm 10.0 RET NTRK1
29 peripheral nervous system benign neoplasm 10.0 RET NTRK1
30 mucosal melanoma 10.0 TERT BRAF
31 substernal goiter 10.0 TG PTH
32 solid adenocarcinoma with mucin production 10.0 RET NKX2-1
33 multiple endocrine neoplasia, type iib 10.0 RET NTRK1
34 thyroid angiosarcoma 10.0 TG TERT NKX2-1
35 lung benign neoplasm 10.0 TERT NKX2-1 MET
36 clear cell adenoma 10.0 TG PTH
37 postsurgical hypothyroidism 10.0 TG PTH
38 thyroid cancer, nonmedullary, 2 10.0 TG LGALS3 BRAF
39 malignant pheochromocytoma 10.0 TERT LGALS3
40 melanoma, uveal 10.0 TERT MET BRAF
41 hypertrophic pyloric stenosis 10.0 RET NTRK1
42 endemic goiter 10.0 TG PTH
43 anal spasm 10.0 TG PTH
44 plummer's disease 9.9 TG PTH
45 nontoxic goiter 9.9 TG PTH
46 benign mesothelioma 9.9 NKX2-1 KRT19
47 colorectal adenocarcinoma 9.9 TERT NKX2-1 BRAF
48 graves disease 1 9.9 TG PTH
49 nasal cavity olfactory neuroblastoma 9.9 TG NKX2-1 KRT19
50 ovarian germ cell cancer 9.9 TG NKX2-1 KRT19

Graphical network of the top 20 diseases related to Tall Cell Variant Papillary Carcinoma:



Diseases related to Tall Cell Variant Papillary Carcinoma

Symptoms & Phenotypes for Tall Cell Variant Papillary Carcinoma

GenomeRNAi Phenotypes related to Tall Cell Variant Papillary Carcinoma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.47 BRAF
2 Decreased viability GR00055-A-2 9.47 BRAF
3 Decreased viability GR00221-A-1 9.47 RET
4 Decreased viability GR00221-A-2 9.47 RET
5 Decreased viability GR00221-A-3 9.47 NTRK1
6 Decreased viability GR00221-A-4 9.47 BRAF RET
7 Decreased viability GR00249-S 9.47 BRAF NTRK1
8 Decreased viability GR00301-A 9.47 BRAF NTRK1 RET
9 Decreased viability GR00381-A-1 9.47 BRAF
10 Decreased viability GR00402-S-2 9.47 RET
11 Decreased substrate adherent cell growth GR00193-A-1 9.43 MET
12 Decreased substrate adherent cell growth GR00193-A-3 9.43 BRAF MET
13 Decreased substrate adherent cell growth GR00193-A-4 9.43 BRAF MET NTRK1
14 Decreased cell viability after pRB stimulation GR00230-A-1 8.85 NTRK1

MGI Mouse Phenotypes related to Tall Cell Variant Papillary Carcinoma:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.19 BRAF KRT19 LGALS3 MET NKX2-1 NTRK1
2 cellular MP:0005384 10.14 BRAF KRT19 LGALS3 MET NKX2-1 PTH
3 digestive/alimentary MP:0005381 10.13 BRAF KRT19 LGALS3 MET NKX2-1 RET
4 immune system MP:0005387 10.13 BRAF KRT19 LGALS3 MET NTRK1 PTH
5 endocrine/exocrine gland MP:0005379 10.11 BRAF KRT19 MET NKX2-1 PTH RET
6 cardiovascular system MP:0005385 10.09 BRAF KRT19 LGALS3 MET NKX2-1 PTH
7 mortality/aging MP:0010768 10.09 BRAF KRT19 LGALS3 MET NKX2-1 NTRK1
8 nervous system MP:0003631 10.02 BRAF KRT19 LGALS3 MET NKX2-1 NTRK1
9 neoplasm MP:0002006 9.95 BRAF KRT19 LGALS3 MET NKX2-1 RET
10 limbs/digits/tail MP:0005371 9.93 BRAF MET NTRK1 PTH RET TG
11 normal MP:0002873 9.8 BRAF KRT19 MET NKX2-1 NTRK1 RET
12 no phenotypic analysis MP:0003012 9.72 KRT19 MET NKX2-1 NTRK1 RET
13 reproductive system MP:0005389 9.7 BRAF KRT19 LGALS3 NKX2-1 RET TERT
14 respiratory system MP:0005388 9.5 BRAF KRT19 LGALS3 MET NKX2-1 RET
15 skeleton MP:0005390 9.17 BRAF KRT19 LGALS3 NKX2-1 PTH TERT

Drugs & Therapeutics for Tall Cell Variant Papillary Carcinoma

Search Clinical Trials , NIH Clinical Center for Tall Cell Variant Papillary Carcinoma

Genetic Tests for Tall Cell Variant Papillary Carcinoma

Anatomical Context for Tall Cell Variant Papillary Carcinoma

MalaCards organs/tissues related to Tall Cell Variant Papillary Carcinoma:

40
Thyroid, Lung, Skin, Thymus, Colon, Liver, Breast

Publications for Tall Cell Variant Papillary Carcinoma

Articles related to Tall Cell Variant Papillary Carcinoma:

# Title Authors PMID Year
1
MOLECULAR PROFILE AND CLINICAL OUTCOMES IN DIFFERENTIATED THYROID CANCER PATIENTS PRESENTING WITH BONE METASTASIS. 61
31412230 2019
2
Anaplastic Spindle Cell Squamous Carcinoma Arising from Tall Cell Variant Papillary Carcinoma of the Thyroid Gland: A Case Report and Review of the Literature. 61
28484653 2017
3
c-Met expression in tall cell variant papillary carcinoma of the thyroid. 61
14508824 2003

Variations for Tall Cell Variant Papillary Carcinoma

Expression for Tall Cell Variant Papillary Carcinoma

Search GEO for disease gene expression data for Tall Cell Variant Papillary Carcinoma.

Pathways for Tall Cell Variant Papillary Carcinoma

Pathways related to Tall Cell Variant Papillary Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.88 RET NTRK1 MET
2 11.75 TERT RET NTRK1 MET BRAF
3 11.6 RET NTRK1 MET
4 11.46 TERT MET KRT19
5 10.98 RET NTRK1 MET
6 10.95 MET BRAF

GO Terms for Tall Cell Variant Papillary Carcinoma

Cellular components related to Tall Cell Variant Papillary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 RET NTRK1 MET

Biological processes related to Tall Cell Variant Papillary Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.8 RET NTRK1 MET BRAF
2 protein phosphorylation GO:0006468 9.73 RET NTRK1 MET BRAF
3 axon guidance GO:0007411 9.63 RET NTRK1 NKX2-1
4 cellular response to nerve growth factor stimulus GO:1990090 9.52 NTRK1 BRAF
5 positive regulation of glucose import GO:0046326 9.51 TERT PTH
6 negative regulation of neuron apoptotic process GO:0043524 9.5 TERT NTRK1 BRAF
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.48 TERT BRAF
8 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.43 RET NTRK1 MET
9 response to cadmium ion GO:0046686 9.4 TERT PTH
10 innervation GO:0060384 9.37 RET NTRK1
11 positive regulation of kinase activity GO:0033674 9.33 RET NTRK1 MET
12 peptidyl-tyrosine phosphorylation GO:0018108 9.26 RET NTRK1 MET BRAF
13 thyroid gland development GO:0030878 8.8 TG NKX2-1 BRAF

Molecular functions related to Tall Cell Variant Papillary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.56 RET NTRK1 MET BRAF
2 protein kinase activity GO:0004672 9.46 RET NTRK1 MET BRAF
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 RET NTRK1 MET
4 protein tyrosine kinase activity GO:0004713 8.92 RET NTRK1 MET BRAF

Sources for Tall Cell Variant Papillary Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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