MCID: TNY001
MIFTS: 29

Tanycytic Ependymoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Tanycytic Ependymoma

MalaCards integrated aliases for Tanycytic Ependymoma:

Name: Tanycytic Ependymoma 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5504
NCIt 50 C6903
SNOMED-CT 68 57706008
UMLS 72 C1370500

Summaries for Tanycytic Ependymoma

MalaCards based summary : Tanycytic Ependymoma is related to ependymoma and benign ependymoma. An important gene associated with Tanycytic Ependymoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include spinal cord and brain, and related phenotypes are Increased proliferation and growth/size/body region

Related Diseases for Tanycytic Ependymoma

Diseases related to Tanycytic Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 ependymoma 32.1 SYP NF2 NES MEN1 GFAP
2 benign ependymoma 31.6 SYP RBFOX3 NF2 GFAP
3 obstructive hydrocephalus 31.2 SYP GFAP
4 neurilemmoma 30.7 SMARCB1 NF2 NES GFAP
5 hydrocephalus 30.7 SYP NES GFAP
6 spinal meningioma 30.5 NF2 CHGA
7 meningioma, radiation-induced 30.4 NF2 GFAP
8 multiple endocrine neoplasia, type i 29.7 SYP MEN1 CHGA
9 meningioma, familial 29.6 SYP SMARCB1 NF2 MEN1 GFAP
10 subependymoma 29.5 SYP NES GFAP CHGA
11 ganglioglioma 28.8 SYP SMARCB1 NES GFAP CHGA
12 extraventricular neurocytoma 10.7 SYP GFAP
13 desmoplastic infantile ganglioglioma 10.7 SYP GFAP
14 lung combined type small cell carcinoma 10.7 SYP GFAP
15 cerebral convexity meningioma 10.7 NF2 GFAP
16 chiari malformation 10.7 SYP GFAP
17 intraventricular meningioma 10.7 NF2 GFAP
18 clear cell ependymoma 10.7 SYP GFAP
19 cerebral neuroblastoma 10.7 SYP GFAP
20 subependymal glioma 10.7 SYP GFAP
21 cornea cancer 10.7 NF2 GFAP
22 spinal cancer 10.7 NF2 GFAP
23 pineal gland cancer 10.7 SYP GFAP
24 plexiform schwannoma 10.7 NF2 GFAP
25 angiocentric glioma 10.6 SYP GFAP
26 astrocytoma 10.6
27 melanotic neuroectodermal tumor 10.6 SYP GFAP
28 chordoid glioma 10.6 NF2 GFAP
29 atypical neurofibroma 10.6 NF2 GFAP
30 malignant ependymoma 10.6 NF2 GFAP
31 neurilemmoma of the fifth cranial nerve 10.6 NF2 GFAP
32 trigeminal nerve neoplasm 10.6 NF2 GFAP
33 pineoblastoma 10.6 SYP GFAP
34 papilloma of choroid plexus 10.6 SYP GFAP
35 partial motor epilepsy 10.6 SYP RBFOX3
36 neurofibromatosis, type iv, of riccardi 10.6
37 cystic teratoma 10.5 SYP GFAP
38 gangliocytoma 10.5 SYP RBFOX3
39 tuberculum sellae meningioma 10.5 SYP RBFOX3
40 melanotic medulloblastoma 10.5 SMARCB1 GFAP
41 central nervous system benign neoplasm 10.5 SYP GFAP
42 sella turcica neoplasm 10.5 SYP RBFOX3
43 pilocytic astrocytoma 10.5
44 pilomyxoid astrocytoma 10.5 SYP GFAP
45 monosomy 22 10.5 SMARCB1 NF2
46 nodular medulloblastoma 10.5 SMARCB1 GFAP
47 extraosseous chondrosarcoma 10.5 SYP SMARCB1
48 anaplastic ganglioglioma 10.5 NES GFAP
49 schwannomatosis 1 10.5 SMARCB1 NF2
50 central nervous system germ cell tumor 10.5 NES GFAP

Graphical network of the top 20 diseases related to Tanycytic Ependymoma:



Diseases related to Tanycytic Ependymoma

Symptoms & Phenotypes for Tanycytic Ependymoma

GenomeRNAi Phenotypes related to Tanycytic Ependymoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.8 MEN1 NF2 SMARCB1

MGI Mouse Phenotypes related to Tanycytic Ependymoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 CHGA GFAP KDM6A KMT2D MEN1 NF2
2 muscle MP:0005369 9.7 CHGA GFAP KDM6A KMT2D MEN1 OLIG2
3 neoplasm MP:0002006 9.43 KDM6A KMT2D MEN1 NF2 OLIG2 SMARCB1
4 nervous system MP:0003631 9.28 CHGA GFAP KDM6A KMT2D MEN1 NF2

Drugs & Therapeutics for Tanycytic Ependymoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Exploring Outcomes and Risk in Patients With Rare Central Nervous System Tumors Recruiting NCT03251989

Search NIH Clinical Center for Tanycytic Ependymoma

Genetic Tests for Tanycytic Ependymoma

Anatomical Context for Tanycytic Ependymoma

MalaCards organs/tissues related to Tanycytic Ependymoma:

41
Spinal Cord, Brain

Publications for Tanycytic Ependymoma

Articles related to Tanycytic Ependymoma:

(show top 50) (show all 54)
# Title Authors PMID Year
1
Extramedullary Tanycytic Ependymoma in a 12-Year-Old Boy. 38
31001044 2019
2
Tanycytic ependymoma of filum terminale: Clinical characteristics and surgical outcomes. 38
30546423 2018
3
Tanycytic ependymoma of the brain stem, presentations of rare cystic disease variants and review of literature. 38
28884561 2018
4
The clinical features and surgical outcomes of intracranial tanycytic ependymomas: a single-institutional experience. 38
28653235 2017
5
Two Cases of Spinal Tanycytic Ependymoma Associated with Neurofibromatosis Type 2. 38
28345553 2017
6
Squash cytology of tanycytic ependymoma: A report of two cases. 38
27879059 2017
7
Spinal cordectomy: A new hope for morbid spinal conditions. 38
27846400 2017
8
Tanycytic ependymoma of cervical cord presenting with spontaneous intratumoral hemorrhage. 38
27033310 2016
9
Imaging features of spinal tanycytic ependymoma. 38
26755489 2016
10
Spinal ependymoma in a patient with Kabuki syndrome: a case report. 38
26341229 2015
11
Supratentorial tanycytic ependymoma in an adult male: case report and review of literature. 38
25873884 2015
12
Cerebral and spinal cord tanycytic ependymomas in a young adult with a mutation in the NF2 gene. 38
24612193 2014
13
Spinal tanycytic ependymoma associated with neurofibromatosis type 2. 38
24495349 2014
14
Pediatric supratentorial cortical tanycytic ependymoma associated with absence seizures. 38
24569174 2014
15
Mystery case: tanycytic ependymoma of the conus medullaris: a rare cause of low back pain. 38
24960834 2014
16
intraventricular tanycytic ependymoma: an uncommon fibrillary variant. 38
24823737 2014
17
Tanycytic ependymoma in a 76-year-old Puerto Rican male. 38
25550817 2014
18
Vestibular schwannoma or tanycytic ependymoma: Immunohistologic staining reveals. 38
25506503 2014
19
Features of intraventricular tanycytic ependymoma: report of a case and review of literature. 38
25031767 2014
20
A cortical cystic epileptogenic lesion: tanycytic ependymoma. 38
23160807 2013
21
Tanycytic ependymoma of the filum terminale associated with multiple endocrine neoplasia type 1: first reported case. 38
23562332 2013
22
A 40-year-old male with an intraventricular tumor. Combined tanycytic ependymoma and subependymoma. 38
23587142 2013
23
Tanycytic ependymoma: a challenging histological diagnosis. 38
23476839 2013
24
Cyst with a mural nodule tumor of the brain. 38
22935908 2012
25
Spinal tanycytic ependymoma with diffusion restriction on MRI. 38
22427295 2012
26
Tanycytic ependymoma of filum terminale: a case report. 38
22056760 2012
27
Supratentorial tanycytic ependymoma: an uncommon fibrillary ependymoma variant. 38
21877052 2011
28
A rare case of spinal dumbbell tanycytic ependymoma. 38
21270701 2011
29
Spinal cord tanycytic ependymoma associated with neurofibromatosis type 2. 38
20403699 2010
30
Rapid spontaneous malignant progression of supratentorial tanycytic ependymoma with sarcomatous features - "Ependymosarcoma". 38
19853384 2010
31
Tanycytic ependymoma of the filum terminale with pleomorphic giant cells. 38
19856219 2009
32
Tanycytic ependymoma of the spinal cord with anaplastic cytological features. 38
19408091 2009
33
Tanycytic ependymoma arising from the right lateral ventricle: a case report and review of the literature. 38
18312548 2008
34
Pediatric tanycytic ependymoma of the cauda equina: case report and review of the literature. 38
18401036 2008
35
A case of tanycytic ependymoma arising from the cerebral hemisphere. 38
18095125 2006
36
Familial intracranial ependymomas. Report of three cases in a family and review of the literature. 38
16459998 2006
37
Spinal tanycytic ependymoma with hematomyelia--case report--. 38
15782011 2005
38
Intraventricular tanycytic ependymoma: case report and review of the literature. 38
15690137 2005
39
A case of cervicomedullary junction tanycytic ependymoma associated with marked cyst formation. 38
18095101 2005
40
Supratentorial tanycytic ependymoma. 38
15519882 2004
41
Textiloma (gossypiboma) mimicking recurrent intracranial tumor. 38
15214828 2004
42
Tanycytic ependymoma of the spinal cord. Case report and review of the literature. 38
14735006 2003
43
[The new WHO classification of tumors of the nervous system 2000. Pathology and genetics]. 38
12185780 2002
44
The WHO classification of tumors of the nervous system. 38
11895036 2002
45
Spinal tanycytic ependymoma associated with neurofibromatosis type 2--case report. 38
11760389 2001
46
Tanycytic ependymoma in association with neurofibromatosis type 2. 38
11430494 2001
47
Intraoperative diagnosis of tanycytic ependymoma: pitfalls and differential diagnosis. 38
11285628 2001
48
Spinal tanycytic ependymomas. 38
11194940 2001
49
Prognostic value of Ki-67 (MIB-1) and p53 in ependymomas. 38
11908872 2001
50
Ganglioglioma with a tanycytic ependymoma as the glial component. 38
10663975 2000

Variations for Tanycytic Ependymoma

Expression for Tanycytic Ependymoma

Search GEO for disease gene expression data for Tanycytic Ependymoma.

Pathways for Tanycytic Ependymoma

Pathways related to Tanycytic Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 SYP RBFOX3 NF2 GFAP
2 10.82 SYP OLIG2 NES GFAP

GO Terms for Tanycytic Ependymoma

Cellular components related to Tanycytic Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MLL3/4 complex GO:0044666 8.96 KMT2D KDM6A
2 histone methyltransferase complex GO:0035097 8.8 MEN1 KMT2D KDM6A

Biological processes related to Tanycytic Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.46 SMARCB1 RBFOX3 OLIG2 NES
2 beta-catenin-TCF complex assembly GO:1904837 9.26 MEN1 KMT2D
3 histone H3-K4 methylation GO:0051568 8.96 KMT2D KDM6A
4 chromatin organization GO:0006325 8.92 SMARCB1 MEN1 KMT2D KDM6A

Molecular functions related to Tanycytic Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone-lysine N-methyltransferase activity GO:0018024 8.62 MEN1 KMT2D

Sources for Tanycytic Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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