MCID: TNY001
MIFTS: 29

Tanycytic Ependymoma

Categories: Cancer diseases

Aliases & Classifications for Tanycytic Ependymoma

MalaCards integrated aliases for Tanycytic Ependymoma:

Name: Tanycytic Ependymoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5504
NCIt 50 C6903
SNOMED-CT 68 397378002 57706008
UMLS 73 C1370500

Summaries for Tanycytic Ependymoma

MalaCards based summary : Tanycytic Ependymoma is related to ependymoma and pilocytic astrocytoma. An important gene associated with Tanycytic Ependymoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include spinal cord and brain, and related phenotypes are Increased proliferation and growth/size/body region

Related Diseases for Tanycytic Ependymoma

Diseases related to Tanycytic Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 ependymoma 31.5 GFAP MEN1 NES NF2 SYP
2 pilocytic astrocytoma 30.4 GFAP OLIG2 SYP
3 multiple endocrine neoplasia, type i 29.2 CHGA MEN1 SYP
4 subependymoma 29.0 CHGA GFAP NES SYP
5 desmoplastic infantile ganglioglioma 10.9 GFAP SYP
6 extraventricular neurocytoma 10.9 GFAP SYP
7 lung combined type small cell carcinoma 10.9 GFAP SYP
8 cerebral convexity meningioma 10.9 GFAP NF2
9 pilomyxoid astrocytoma 10.9 GFAP SYP
10 intraventricular meningioma 10.9 GFAP NF2
11 subependymal glioma 10.9 GFAP SYP
12 chiari malformation 10.9 GFAP SYP
13 cornea cancer 10.9 GFAP NF2
14 cerebral neuroblastoma 10.9 GFAP SYP
15 pineal gland cancer 10.8 GFAP SYP
16 spinal cancer 10.8 GFAP NF2
17 melanotic neuroectodermal tumor 10.8 GFAP SYP
18 angiocentric glioma 10.8 GFAP SYP
19 obstructive hydrocephalus 10.8 GFAP SYP
20 plexiform schwannoma 10.8 GFAP NF2
21 chordoid glioma 10.8 GFAP NF2
22 atypical neurofibroma 10.8 GFAP NF2
23 malignant ependymoma 10.8 GFAP NF2
24 pineoblastoma 10.8 GFAP SYP
25 melanotic medulloblastoma 10.7 GFAP SMARCB1
26 papilloma of choroid plexus 10.7 GFAP SYP
27 monosomy 22 10.7 NF2 SMARCB1
28 nodular medulloblastoma 10.7 GFAP SMARCB1
29 schwannomatosis 1 10.7 NF2 SMARCB1
30 cystic teratoma 10.7 GFAP SYP
31 extraosseous chondrosarcoma 10.7 SMARCB1 SYP
32 central nervous system teratoma 10.6 GFAP NES
33 anaplastic ganglioglioma 10.6 GFAP NES
34 sella turcica neoplasm 10.6 RBFOX3 SYP
35 tuberculum sellae meningioma 10.6 RBFOX3 SYP
36 central nervous system germ cell tumor 10.6 GFAP NES
37 benign ependymoma 10.6 GFAP NF2 SYP
38 anaplastic ependymoma 10.6 GFAP NF2 SYP
39 small cell sarcoma 10.6 NF2 SMARCB1
40 ependymoblastoma 10.6 GFAP NES
41 choroid plexus cancer 10.6 GFAP SMARCB1
42 gliomatosis cerebri 10.5 GFAP NES
43 brain ischemia 10.5 GFAP NES
44 rhabdoid cancer 10.5 SMARCB1 SYP
45 pineal parenchymal tumor of intermediate differentiation 10.5 RBFOX3 SYP
46 neurilemmomatosis 10.5 NF2 SMARCB1
47 pancreatic somatostatinoma 10.5 MEN1 SYP
48 medullomyoblastoma 10.4 GFAP SMARCB1 SYP
49 atypical teratoid rhabdoid tumor 10.4 GFAP SMARCB1 SYP
50 neuroma 10.4 GFAP NF2 SMARCB1

Graphical network of the top 20 diseases related to Tanycytic Ependymoma:



Diseases related to Tanycytic Ependymoma

Symptoms & Phenotypes for Tanycytic Ependymoma

GenomeRNAi Phenotypes related to Tanycytic Ependymoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.8 MEN1 NF2 SMARCB1

MGI Mouse Phenotypes related to Tanycytic Ependymoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 NF2 OLIG2 SMARCB1 CHGA GFAP KDM6A
2 muscle MP:0005369 9.63 OLIG2 SMARCB1 GFAP KDM6A KMT2D MEN1
3 neoplasm MP:0002006 9.35 NF2 OLIG2 SMARCB1 KMT2D MEN1
4 nervous system MP:0003631 9.23 NF2 OLIG2 SMARCB1 SYP GFAP KDM6A

Drugs & Therapeutics for Tanycytic Ependymoma

Search Clinical Trials , NIH Clinical Center for Tanycytic Ependymoma

Genetic Tests for Tanycytic Ependymoma

Anatomical Context for Tanycytic Ependymoma

MalaCards organs/tissues related to Tanycytic Ependymoma:

41
Spinal Cord, Brain

Publications for Tanycytic Ependymoma

Articles related to Tanycytic Ependymoma:

(show all 40)
# Title Authors Year
1
Tanycytic ependymoma of the brain stem, presentations of rare cystic disease variants and review of literature. ( 28884561 )
2017
2
Two Cases of Spinal Tanycytic Ependymoma Associated with Neurofibromatosis Type 2. ( 28345553 )
2017
3
Tanycytic ependymoma vs pilocytic astrocytoma? Pitfalls in diagnosis. ( 27773093 )
2016
4
Imaging features of spinal tanycytic ependymoma. ( 26755489 )
2016
5
Squash cytology of tanycytic ependymoma: A report of two cases. ( 27879059 )
2016
6
Tanycytic ependymoma of cervical cord presenting with spontaneous intratumoral hemorrhage. ( 27033310 )
2016
7
Supratentorial tanycytic ependymoma in an adult male: case report and review of literature. ( 25873884 )
2015
8
Cerebral and spinal cord tanycytic ependymomas in a young adult with a mutation in the NF2 gene. ( 24612193 )
2014
9
Vestibular schwannoma or tanycytic ependymoma: Immunohistologic staining reveals. ( 25506503 )
2014
10
Pediatric supratentorial cortical tanycytic ependymoma associated with absence seizures. ( 24569174 )
2014
11
Tanycytic ependymoma in a 76-year-old Puerto Rican male. ( 25550817 )
2014
12
intraventricular tanycytic ependymoma: an uncommon fibrillary variant. ( 24823737 )
2014
13
Spinal tanycytic ependymoma associated with neurofibromatosis type 2. ( 24495349 )
2014
14
Mystery case: tanycytic ependymoma of the conus medullaris: a rare cause of low back pain. ( 24960834 )
2014
15
Features of intraventricular tanycytic ependymoma: report of a case and review of literature. ( 25031767 )
2014
16
Tanycytic ependymoma of the filum terminale associated with multiple endocrine neoplasia type 1: first reported case. ( 23562332 )
2013
17
Tanycytic ependymoma: a challenging histological diagnosis. ( 23476839 )
2013
18
A 40-year-old male with an intraventricular tumor. Combined tanycytic ependymoma and subependymoma. ( 23587142 )
2013
19
A cortical cystic epileptogenic lesion: tanycytic ependymoma. ( 23160807 )
2013
20
Spinal tanycytic ependymoma with diffusion restriction on MRI. ( 22427295 )
2012
21
Tanycytic ependymoma of filum terminale: a case report. ( 22056760 )
2012
22
A rare case of spinal dumbbell tanycytic ependymoma. ( 21270701 )
2011
23
Supratentorial tanycytic ependymoma: an uncommon fibrillary ependymoma variant. ( 21877052 )
2011
24
Rapid spontaneous malignant progression of supratentorial tanycytic ependymoma with sarcomatous features - "Ependymosarcoma". ( 19853384 )
2010
25
Spinal cord tanycytic ependymoma associated with neurofibromatosis type 2. ( 20403699 )
2010
26
Tanycytic ependymoma of the spinal cord with anaplastic cytological features. ( 19408091 )
2009
27
Tanycytic ependymoma of the filum terminale with pleomorphic giant cells. ( 19856219 )
2009
28
Pediatric tanycytic ependymoma of the cauda equina: case report and review of the literature. ( 18401036 )
2008
29
Tanycytic ependymoma arising from the right lateral ventricle: a case report and review of the literature. ( 18312548 )
2008
30
A case of tanycytic ependymoma arising from the cerebral hemisphere. ( 18095125 )
2006
31
A case of cervicomedullary junction tanycytic ependymoma associated with marked cyst formation. ( 18095101 )
2005
32
Spinal tanycytic ependymoma with hematomyelia--case report--. ( 15782011 )
2005
33
Intraventricular tanycytic ependymoma: case report and review of the literature. ( 15690137 )
2005
34
Supratentorial tanycytic ependymoma. ( 15519882 )
2004
35
Tanycytic ependymoma of the spinal cord. Case report and review of the literature. ( 14735006 )
2003
36
Tanycytic ependymoma in association with neurofibromatosis type 2. ( 11430494 )
2001
37
Spinal tanycytic ependymoma associated with neurofibromatosis type 2--case report. ( 11760389 )
2001
38
Intraoperative diagnosis of tanycytic ependymoma: pitfalls and differential diagnosis. ( 11285628 )
2001
39
The tanycytic ependymoma of the lateral ventricle: case report. ( 10667826 )
1999
40
Tanycytic ependymoma. ( 9090024 )
1997

Variations for Tanycytic Ependymoma

Expression for Tanycytic Ependymoma

Search GEO for disease gene expression data for Tanycytic Ependymoma.

Pathways for Tanycytic Ependymoma

Pathways related to Tanycytic Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 GFAP NF2 RBFOX3 SYP
2 10.82 GFAP NES OLIG2 SYP

GO Terms for Tanycytic Ependymoma

Cellular components related to Tanycytic Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.33 KDM6A MEN1 SMARCB1
2 MLL3/4 complex GO:0044666 8.96 KDM6A KMT2D
3 histone methyltransferase complex GO:0035097 8.8 KDM6A KMT2D MEN1

Biological processes related to Tanycytic Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.46 NES OLIG2 RBFOX3 SMARCB1
2 histone H3-K4 methylation GO:0051568 8.96 KDM6A KMT2D
3 chromatin organization GO:0006325 8.92 KDM6A KMT2D MEN1 SMARCB1

Sources for Tanycytic Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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