TAQ1
MCID: TQP001
MIFTS: 29

Taqi Polymorphism (TAQ1)

Aliases & Classifications for Taqi Polymorphism

MalaCards integrated aliases for Taqi Polymorphism:

Name: Taqi Polymorphism 57
Taq1 57

External Ids:

OMIM® 57 313480

Summaries for Taqi Polymorphism

MalaCards based summary : Taqi Polymorphism, also known as taq1, is related to kleptomania and traumatic brain injury. An important gene associated with Taqi Polymorphism is VDR (Vitamin D Receptor), and among its related pathways/superpathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics. Affiliated tissues include breast, bone and prostate, and related phenotypes are Decreased LDL uptake and hematopoietic system

More information from OMIM: 313480

Related Diseases for Taqi Polymorphism

Diseases related to Taqi Polymorphism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 kleptomania 10.2 DRD2 ANKK1
2 traumatic brain injury 10.2 DRD2 ANKK1
3 brain injury 10.2 DRD2 ANKK1
4 hallucinogen dependence 10.2 DRD2 ANKK1
5 cannabis abuse 10.2 DRD2 ANKK1
6 colon sarcoma 10.2 VDR TGFA
7 impulse control disorder 10.2 DRD2 ANKK1
8 pathological gambling 10.2 DRD2 ANKK1
9 alexithymia 10.2 DRD2 ANKK1
10 oppositional defiant disorder 10.1 DRD2 ANKK1
11 idiopathic hypercalciuria 10.1 VDR REN
12 premenstrual tension 10.1 REN ANKK1
13 neuroleptic malignant syndrome 10.1 DRD2 ANKK1
14 heroin dependence 10.1 DRD2 ANKK1
15 aortic valve insufficiency 10.1 REN ACTA2
16 leprosy 3 10.1
17 cleft lip 10.1
18 hansen's disease 10.1
19 opiate dependence 10.0 DRD2 ANKK1
20 arteries, anomalies of 10.0
21 multiple sclerosis 10.0
22 lipoprotein quantitative trait locus 10.0
23 rickets 10.0
24 substance abuse 10.0
25 mitral valve stenosis 9.9 REN FGA
26 alcohol dependence 9.9
27 cleft palate, isolated 9.9
28 attention deficit-hyperactivity disorder 9.9
29 hypercholesterolemia, familial, 1 9.9
30 hypertension, essential 9.9
31 prostate cancer 9.9
32 tobacco addiction 9.9
33 lipoid congenital adrenal hyperplasia 9.9
34 type 1 diabetes mellitus 9.9
35 periodontitis, chronic 9.9
36 aarskog-scott syndrome 9.9
37 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
38 smoking as a quantitative trait locus 3 9.9
39 inflammatory bowel disease 9.9
40 polycystic kidney disease 9.9
41 lepromatous leprosy 9.9
42 hereditary spherocytosis 9.9
43 familial hypercholesterolemia 9.9
44 aggressive periodontitis 9.9
45 hereditary elliptocytosis 9.9
46 high grade glioma 9.9
47 lipid metabolism disorder 9.9
48 myopathy 9.9
49 infertility 9.9
50 nephrolithiasis 9.9

Graphical network of the top 20 diseases related to Taqi Polymorphism:



Diseases related to Taqi Polymorphism

Symptoms & Phenotypes for Taqi Polymorphism

Clinical features from OMIM®:

313480 (Updated 05-Mar-2021)

GenomeRNAi Phenotypes related to Taqi Polymorphism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased LDL uptake GR00340-A-1 8.32 LDLR

MGI Mouse Phenotypes related to Taqi Polymorphism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 CCNA2 DRD2 FGA IL12B INHBA LDLR
2 digestive/alimentary MP:0005381 9.87 DRD2 FGA IL12B INHBA LDLR TGFA
3 immune system MP:0005387 9.81 CCNA2 DRD2 FGA IL12B LDLR REN
4 integument MP:0010771 9.5 DRD2 FGA GCDH INHBA LDLR TGFA
5 muscle MP:0005369 9.17 ACTA2 DRD2 INHBA LDLR REN TGFA

Drugs & Therapeutics for Taqi Polymorphism

Search Clinical Trials , NIH Clinical Center for Taqi Polymorphism

Genetic Tests for Taqi Polymorphism

Anatomical Context for Taqi Polymorphism

MalaCards organs/tissues related to Taqi Polymorphism:

40
Breast, Bone, Prostate, Brain, Liver, Skin, Ovary

Publications for Taqi Polymorphism

Articles related to Taqi Polymorphism:

(show top 50) (show all 474)
# Title Authors PMID Year
1
Single-copy sequence hybridizes to polymorphic and homologous loci on human X and Y chromosomes. 57
6291041 1982
2
Association of serum levels and receptor genes BsmI, TaqI and FokI polymorphisms of vitamin D with the severity of multiple sclerosis. 61
33485603 2021
3
Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian women. 61
33559788 2021
4
Ethnicity as modifier of risk for Vitamin D receptors polymorphisms: Comprehensive meta-analysis of all cancer sites. 61
33387627 2021
5
Diverse Effects of Combinations of Maternal-Neonatal VDR Polymorphisms and 25-Hydroxyvitamin D Concentrations on Neonatal Birth Anthropometry: Functional Phenocopy Variability Dependence, Highlights the Need for Targeted Maternal 25-Hydroxyvitamin D Cut-Offs during Pregnancy. 61
33572874 2021
6
Associations between vitamin D receptor gene polymorphisms and spinal degenerative disease: evidence from a meta-analysis based on 35 case-control studies. 61
33160714 2021
7
Genetic risk factors for lumbar disc disease. 61
32583875 2021
8
Vitamin D receptor ApaI (rs7975232), BsmI (rs1544410), Fok1 (rs2228570), and TaqI (rs731236) gene polymorphisms and susceptibility to pulmonary tuberculosis in an Iranian population: A systematic review and meta-analysis. 61
31740220 2020
9
Association of vitamin D receptor gene FokI and TaqI polymorphisms and risk of RDS. 61
30760068 2020
10
Genetic Polymorphisms of Vitamin D Receptor Gene are Associated with Cervical Cancer Risk in Northeastern Thailand. 61
33112551 2020
11
Association of vitamin D gene polymorphisms in children with asthma - A systematic review. 61
32939414 2020
12
Association of ApaI and TaqI polymorphisms in VDR Gene with Breast Cancer. 61
32986367 2020
13
Levels of Vitamin D Are Low After Crohn's Disease Is Established But Not Before. 61
31589971 2020
14
Association of Common Single Nucleotide Polymorphisms of Candidate Genes with Gallstone Disease: A Meta-Analysis. 61
32647408 2020
15
Analysis of 25-hydroxy cholecalciferol, immunoglobulin E, and vitamin D receptor single nucleotide polymorphisms (Apa1, Taq1, and Bsm1), among sample of Egyptian children with bronchial asthma: A case-control study. 61
32311846 2020
16
Vitamin D receptor genetic polymorphisms and the risk of multiple sclerosis: A systematic review and meta-analysis. 61
32097613 2020
17
The Association Between VDR and GC Polymorphisms and Lung Cancer Risk: A Systematic Review and Meta-Analysis. 61
32255717 2020
18
The influence of polymorphisms of fat mass and obesity (FTO, rs9939609) and vitamin D receptor (VDR, BsmI, TaqI, ApaI, FokI) genes on weight loss by diet and exercise interventions in non-diabetic overweight/obese Asian Indians in North India. 61
32001813 2020
19
Serum 25-hydroxyvitamin D level and vitamin D receptor (VDR) polymorphisms in patients infected with Leishmania tropica: a case control study. 61
32174704 2020
20
VDR Gene Polymorphisms and Allergic Diseases: Evidence from a Meta-analysis. 61
31752548 2020
21
The possible role of maternal and placental vitamin D receptor polymorphisms and haplotypes in pathogenesis of preeclampsia. 61
31006279 2020
22
Association of Vitamin D with the TaqI Polymorphism of the VDR Gene in Older Women Attending the Basic Health Unit of the Federal District, DF (Brazil). 61
33029399 2020
23
Association between vitamin D receptor gene FokI and TaqI variants with autism spectrum disorder predisposition in Iranian population. 61
31589956 2020
24
Vitamin D Receptor Polymorphisms and Cancer. 61
32918214 2020
25
Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis. 61
31878897 2019
26
Association of vitamin D receptor TaqI and ApaI genetic polymorphisms with nephrolithiasis and end stage renal disease: a meta-analysis. 61
31822280 2019
27
Association of select vitamin D receptor gene polymorphisms with the risk of tobacco-related cancers - a meta-analysis. 61
31690771 2019
28
Vitamin D Receptor Polymorphisms Associated with Susceptibility to Obesity: A Meta-Analysis. 61
31682593 2019
29
Matrix metalloprotease-9 polymorphism and its association with Atherosclerosis - A case-control study in Pakistani population. 61
31622289 2019
30
Genetic variation in the maternal vitamin D receptor FokI gene as a risk factor for recurrent pregnancy loss. 61
31446814 2019
31
Association between vitamin D receptor gene polymorphisms and Graves' disease: a systematic review and meta-analysis. 61
30924084 2019
32
Association of Vitamin D Receptor Gene Polymorphisms and the Risk of Multiple Sclerosis: A Meta Analysis. 61
31677540 2019
33
Association of vitamin D receptor polymorphisms and nephrolithiasis: A meta-analysis. 61
31212049 2019
34
Genetic Variations in VDR could Modulate the Efficacy of Vitamin D3 Supplementation on Inflammatory Markers and Total Antioxidant Capacity among Breast Cancer Women: A Randomized Double Blind Controlled Trial. 61
31350967 2019
35
Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility: an updated meta-analysis. 61
30474246 2019
36
Impact of vitamin D and vitamin D receptor TaqI polymorphism in primary human myoblasts. 61
31252402 2019
37
Vitamin D receptor (VDR) TaqI polymorphism, vitamin D and bone mineral density in patients with inflammatory bowel diseases. 61
30929318 2019
38
Vitamin D Receptor gene polymorphisms and plasma levels are associated with lumbar disc degeneration. 61
31127184 2019
39
Vitamin D status and vitamin D receptor gene polymorphism in Saudi children with acute lower respiratory tract infection. 61
30721418 2019
40
The effect of VDR gene polymorphisms and vitamin D level on blood pressure, risk of preeclampsia, gestational age, and body mass index. 61
30417411 2019
41
Vitamin D receptor gene polymorphisms and 25(OH) vitamin D: Lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients. 61
30555790 2019
42
An association study of dopaminergic (DRD2) and serotoninergic (5-HT2) gene polymorphism and schizophrenia in a North Indian population. 61
30389402 2019
43
Association of vitamin D binding protein and vitamin D receptor gene polymorphisms in Iranian patients with chronic periodontitis. 61
30083974 2019
44
Human host defence peptide LL37 and anti-cyclic citrullinated peptide antibody in early inflammatory arthritis. 61
31245047 2019
45
Axonal degeneration in Parkinson's disease - Basal ganglia circuitry and D2 receptor availability. 61
31254937 2019
46
Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis. 61
31333781 2019
47
Vitamin D Receptor Gene Polymorphism In Chronic Telogen Effluvium; A Case-Control Study. 61
31632122 2019
48
Positive correlation between vitamin D receptor gene TaqI variant and gastric cancer predisposition in a sample of Iranian population. 61
30666644 2019
49
Vitamin D receptor gene polymorphisms (Apa1 and Taq1) in temporomandibular joint internal derangement/osteoarthritis in a group of Turkish patients. 61
30155592 2018
50
Molecular characterization of Aspergilli isolated from outdoor air. 61
30292392 2018

Variations for Taqi Polymorphism

Expression for Taqi Polymorphism

Search GEO for disease gene expression data for Taqi Polymorphism.

Pathways for Taqi Polymorphism

Pathways related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.55 VDR CCNA2
2 9.92 DRD2 ANKK1

GO Terms for Taqi Polymorphism

Cellular components related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 VDR LDLR IL12B

Biological processes related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.62 VDR LDLR INHBA ACTA2
2 long-term memory GO:0007616 9.37 LDLR DRD2
3 negative regulation of protein secretion GO:0050709 9.26 IL12B DRD2
4 response to drug GO:0042493 9.26 TGFA REN INHBA DRD2
5 regulation of MAPK cascade GO:0043408 9.16 REN DRD2
6 drinking behavior GO:0042756 8.62 REN DRD2

Molecular functions related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 TGFA INHBA IL12B
2 signaling receptor binding GO:0005102 8.92 REN INHBA FGA DRD2

Sources for Taqi Polymorphism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....