TAQ1
MCID: TQP001
MIFTS: 30

Taqi Polymorphism (TAQ1)

Aliases & Classifications for Taqi Polymorphism

MalaCards integrated aliases for Taqi Polymorphism:

Name: Taqi Polymorphism 57
Taq1 57

External Ids:

OMIM 57 313480

Summaries for Taqi Polymorphism

MalaCards based summary : Taqi Polymorphism, also known as taq1, is related to impulse control disorder and heroin dependence. An important gene associated with Taqi Polymorphism is VDR (Vitamin D Receptor), and among its related pathways/superpathways is Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Dopamine and Bupropion have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and smooth muscle, and related phenotypes are Increased LDL uptake and cardiovascular system

Description from OMIM: 313480

Related Diseases for Taqi Polymorphism

Graphical network of the top 20 diseases related to Taqi Polymorphism:



Diseases related to Taqi Polymorphism

Symptoms & Phenotypes for Taqi Polymorphism

Clinical features from OMIM:

313480

GenomeRNAi Phenotypes related to Taqi Polymorphism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 LDLR UPK1B

MGI Mouse Phenotypes related to Taqi Polymorphism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ACTA2 DRD2 FGA LDLR REN TGFA
2 digestive/alimentary MP:0005381 9.87 DRD2 FGA IL12B INHBA LDLR TGFA
3 hematopoietic system MP:0005397 9.86 CCNA2 DRD2 FGA IL12B INHBA LDLR
4 immune system MP:0005387 9.76 CCNA2 DRD2 FGA IL12B LDLR REN
5 integument MP:0010771 9.43 DRD2 FGA INHBA LDLR TGFA VDR
6 muscle MP:0005369 9.17 ACTA2 DRD2 INHBA LDLR REN TGFA

Drugs & Therapeutics for Taqi Polymorphism

Drugs for Taqi Polymorphism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
3 Raclopride Investigational Phase 4 84225-95-6
4 Neurotransmitter Agents Phase 4
5 Sympathomimetics Phase 4
6 Peripheral Nervous System Agents Phase 4
7 Dopamine Agents Phase 4
8 Antidepressive Agents Phase 4
9 Protective Agents Phase 4
10 Antidepressive Agents, Second-Generation Phase 4
11 Neurotransmitter Uptake Inhibitors Phase 4
12 Psychotropic Drugs Phase 4
13 Cytochrome P-450 Enzyme Inhibitors Phase 4
14 Dopamine Uptake Inhibitors Phase 4
15 Autonomic Agents Phase 4
16 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
17 Cardiotonic Agents Phase 4
18
Dacarbazine Approved, Investigational Phase 1, Phase 2 4342-03-4 5351166
19
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
20
Calcitriol Approved, Nutraceutical Phase 1, Phase 2 32222-06-3 5280453 134070
21 Micronutrients Phase 1, Phase 2
22 Vasoconstrictor Agents Phase 1, Phase 2
23 Antineoplastic Agents, Alkylating Phase 1, Phase 2
24 Bone Density Conservation Agents Phase 1, Phase 2
25 Trace Elements Phase 1, Phase 2
26 Alkylating Agents Phase 1, Phase 2
27 Vitamins Phase 1, Phase 2
28 Calcium, Dietary Phase 1, Phase 2
29
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
30
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
31 Calciferol
32 Dihydroxycholecalciferols
33 Ergocalciferols
34 Vitamin D2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 PET Imaging Study on Occupancy of Dopamine D2 Receptors and Genotypes After Bupropion Administration Completed NCT00846339 Phase 4 Bupropion
2 Phase I/II Study of High-Dose Calcitriol Plus Temodar for Patients With Metastatic Melanoma Completed NCT00301067 Phase 1, Phase 2 Temozolomide
3 Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma Completed NCT02539745
4 Cognitive Processes Study in Obese Women With and Without Eating Disorders Completed NCT01948414 Not Applicable
5 Practice Based Nutrition Intervention-2 Completed NCT01700868 Not Applicable
6 RISSCI-1 Blood Cholesterol Response Study Recruiting NCT03270527 Not Applicable
7 Brain-to-Society Diagnostic for Prevention of Childhood Obesity and Chronic Disease Active, not recruiting NCT03151694
8 Plant-Based Dietary Intervention in Type 2 Diabetes-2 Suspended NCT01931631 Not Applicable

Search NIH Clinical Center for Taqi Polymorphism

Genetic Tests for Taqi Polymorphism

Anatomical Context for Taqi Polymorphism

MalaCards organs/tissues related to Taqi Polymorphism:

41
Kidney, Prostate, Smooth Muscle, Bone, Endothelial

Publications for Taqi Polymorphism

Articles related to Taqi Polymorphism:

(show top 50) (show all 93)
# Title Authors Year
1
Association of VDR gene TaqI polymorphism with the susceptibility to prostate cancer in Asian population evaluated by an updated systematic meta-analysis. ( 29910622 )
2018
2
Vitamin D receptor gene polymorphisms (Apa1 and Taq1) in temporomandibular joint internal derangement/osteoarthritis in a group of Turkish patients. ( 30155592 )
2018
3
Vitamin D Receptor TaqI Polymorphism Is Associated With Reduced Follicle Number in Women Utilizing Assisted Reproductive Technologies. ( 29892263 )
2018
4
Association of dopamine receptor D2 gene (DRD2) Taq1 polymorphisms with eating behaviors and obesity among Chinese and Indian Malaysian university students. ( 29737821 )
2018
5
Association Study of Transforming Growth Factor Alpha TaqI Polymorphism and the Risk of Cleft Lip and/or Palate in an Iranian Population. ( 29105380 )
2017
6
Association between Vitamin D receptor (Cdx2, Fok1, Bsm1, Apa1, Bgl1, Taq1, and Poly (A)) gene polymorphism and breast cancer: A systematic review and meta-analysis. ( 29072133 )
2017
7
Calcitonin Receptor AluI (rs1801197) and Taq1 Calcitonin Genes Polymorphism in 45-and Over 45-year-old Women and their Association with Bone Density. ( 27708484 )
2016
8
Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population. ( 27958635 )
2016
9
The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations' sex differences. ( 26217259 )
2015
10
A novel TaqI polymorphism in the coding region of the ovine TNXB gene in the MHC class III region: morphostructural and physiological influences. ( 23877191 )
2014
11
TaqI polymorphism of VDR gene contributes to breast cancer risk. ( 23904261 )
2014
12
Potential association of vitamin D receptor polymorphism Taq1 with multiple sclerosis. ( 21816760 )
2012
13
VDR TaqI polymorphism is associated with chronic periodontitis in Italian population. ( 21764034 )
2011
14
Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism. ( 21168462 )
2011
15
Genetic variants at the APOE, lipoprotein lipase (LpL), cholesteryl ester transfer protein (CETP), and endothelial nitric oxide (eNOS) genes and coronary artery disease (CAD): CETP Taq1 B2B2 associates with lower risk of CAD in Asian Indians. ( 22460205 )
2010
16
Frequency of fokI and taqI polymorphism of vitamin D receptor gene in Indian population and its association with 25-hydroxyvitamin D levels. ( 21088715 )
2009
17
[Association between the TaqI polymorphism of the vitamin D receptor gene and lepromatous leprosy in a Mexican population sample]. ( 19180314 )
2009
18
Linkage and association of DRD2 gene TaqI polymorphism with schizophrenia in an Iranian population. ( 18426314 )
2008
19
Strong association of the renin TaqI polymorphism with essential hypertension in Chinese Han and Tibetan populations. ( 17476284 )
2007
20
DRD2/ANKK1 TaqI polymorphism and smoking behavior of Egyptian male cigarette smokers. ( 18058350 )
2007
21
Interaction of TaqI polymorphism at exon 9 of the vitamin D receptor gene with the negative lepromin response may favor the occurrence of leprosy. ( 16965356 )
2006
22
An affected pedigree member analysis of linkage between the dopamine D2 receptor gene TaqI polymorphism and obesity and hypertension. ( 15939106 )
2005
23
Does the DRD2-Taq1 A polymorphism influence treatment response to bupropion hydrochloride for reduction of the nicotine withdrawal syndrome? ( 14668077 )
2003
24
A TaqI polymorphism in the 3'UTR of the IL-12 p40 gene correlates with increased IL-12 secretion. ( 12424624 )
2002
25
Nature of the fibrinogen Aalpha gene TaqI polymorphism. ( 11583334 )
2001
26
Stress as a mediating factor in the association between the DRD2 TaqI polymorphism and alcoholism. ( 11331109 )
2001
27
Relationships between the taqI polymorphism of the dopamine D2 receptor and blood pressure in hyperglycaemic and normoglycaemic Chinese subjects. ( 11894971 )
2001
28
Association analysis for dopamine D2 receptor Taq1 polymorphism with P300 event-related potential for normal young females. ( 11702060 )
2001
29
Modulation of blood pressure and obesity with the dopamine D2 receptor gene TaqI polymorphism. ( 10948074 )
2000
30
Familial calcium stone disease: TaqI polymorphism and the vitamin D receptor. ( 10405913 )
1999
31
The DRD2 TaqI polymorphism and symptoms of attention deficit hyperactivity disorder. ( 10578241 )
1999
32
A TaqI polymorphism in the chicken interferon regulatory factor 1 (IRF1) gene provides evidence that chicken linkage group E48C28W13 represents one of the microchromosomes. ( 10380694 )
1999
33
Lack of correlation of free deoxypyridinoline excretion with Taq1 restriction length polymorphisms in the vitamin D receptor gene in males. ( 9641356 )
1998
34
TaqI polymorphism in the 3' flanking region of the PI gene among Kuwaiti Arabs and Russians. ( 9160183 )
1997
35
Chromosomal localization of the human urothelial 'tetraspan' gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism. ( 9073521 )
1997
36
TaqI polymorphism in Oct-1 in chickens. ( 9124723 )
1997
37
A high-frequency TaqI polymorphism at the ovine phenylalanine hydroxylase (PAH)locus. ( 8856909 )
1996
38
Association study of transforming growth factor alpha (TGF alpha) TaqI polymorphism and oral clefts: indication of gene-environment interaction in a population-based sample of infants with birth defects. ( 7702037 )
1995
39
A TaqI polymorphism in the human erythroid beta spectrin gene. ( 7868137 )
1995
40
A TaqI polymorphism in a gene belonging to the human apoprotein(a)-plasminogen gene family on the telomeric region of chromosome 6 (6q26-27). ( 7554370 )
1995
41
An intragenic TaqI polymorphism in the faciogenital dysplasia (FGD1) locus, the gene responsible for Aarskog syndrome. ( 7557980 )
1995
42
A TaqI polymorphism at the porcine arachidonate 12-lipoxygenase (ALOX12) locus. ( 8572372 )
1995
43
PCR detection of the Taq1 restriction fragment length polymorphism linked to the ataxia telangiectasia locus. ( 7720261 )
1995
44
TaqI polymorphism in intron 2 of the GCDH gene. ( 8069322 )
1994
45
A TaqI polymorphism in the bovine blood coagulation factor XIII a subunit gene. ( 7695131 )
1994
46
A compound TaqI polymorphism in sheep revealed by a carbonic anhydrase II (CA2) probe. ( 7818185 )
1994
47
A TaqI polymorphism at the beta-globin (HBB) locus in cattle. ( 7818188 )
1994
48
TaqI polymorphism of the human MXI1 gene. ( 7881441 )
1994
49
TaqI polymorphism of the human tissue inhibitor of metallo-proteinases-2 (Timp2) gene. ( 7909251 )
1994
50
A TaqI polymorphism at the immunoglobulin kappa light chain locus in Merino sheep. ( 8161025 )
1994

Variations for Taqi Polymorphism

Expression for Taqi Polymorphism

Search GEO for disease gene expression data for Taqi Polymorphism.

Pathways for Taqi Polymorphism

Pathways related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.21 CCNA2 VDR

GO Terms for Taqi Polymorphism

Cellular components related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ACTA2 FGA IL12B INHBA REN TGFA
2 receptor complex GO:0043235 8.8 IL12B LDLR VDR

Biological processes related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.56 ACTA2 INHBA LDLR VDR
2 response to drug GO:0042493 9.46 DRD2 INHBA REN TGFA
3 long-term memory GO:0007616 9.32 DRD2 LDLR
4 drinking behavior GO:0042756 8.96 DRD2 REN
5 regulation of MAPK cascade GO:0043408 8.8 DRD2 INHBA REN

Molecular functions related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL12B INHBA TGFA
2 signaling receptor binding GO:0005102 8.92 DRD2 FGA INHBA REN

Sources for Taqi Polymorphism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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