TAQ1
MCID: TQP001
MIFTS: 32

Taqi Polymorphism (TAQ1)

Aliases & Classifications for Taqi Polymorphism

MalaCards integrated aliases for Taqi Polymorphism:

Name: Taqi Polymorphism 56
Taq1 56

External Ids:

OMIM 56 313480

Summaries for Taqi Polymorphism

MalaCards based summary : Taqi Polymorphism, also known as taq1, is related to kleptomania and hallucinogen dependence. An important gene associated with Taqi Polymorphism is VDR (Vitamin D Receptor), and among its related pathways/superpathways is Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics. The drugs Ergocalciferol and Vitamin D have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and t cells, and related phenotypes are Increased LDL uptake and hematopoietic system

More information from OMIM: 313480

Related Diseases for Taqi Polymorphism

Diseases related to Taqi Polymorphism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 kleptomania 10.3 DRD2 ANKK1
2 hallucinogen dependence 10.2 DRD2 ANKK1
3 hyperlipoproteinemia, type iii 10.2
4 coronary artery anomaly 10.2
5 substance abuse 10.2
6 impulse control disorder 10.2 DRD2 ANKK1
7 schizophreniform disorder 10.1 FGA DRD2
8 alexithymia 10.1 DRD2 ANKK1
9 body mass index quantitative trait locus 11 10.1
10 pathological gambling 10.1 DRD2 ANKK1
11 arteries, anomalies of 10.1
12 atherosclerosis susceptibility 10.1
13 multiple sclerosis 10.1
14 ataxia-telangiectasia 10.1
15 ataxia and polyneuropathy, adult-onset 10.1
16 hyperprolactinemia 10.1
17 restless legs syndrome 10.1
18 bone resorption disease 10.1
19 rickets 10.1
20 telangiectasis 10.1
21 osteoarthritis 10.1
22 allergic encephalomyelitis 10.1
23 systemic lupus erythematosus 10.0
24 leprosy 3 10.0
25 cleft lip 10.0
26 hansen's disease 10.0
27 neuroleptic malignant syndrome 10.0 DRD2 ANKK1
28 alcohol dependence 9.9
29 bladder cancer 9.9
30 breast cancer 9.9
31 cleft palate, isolated 9.9
32 attention deficit-hyperactivity disorder 9.9
33 hypercholesterolemia, familial, 1 9.9
34 hypertension, essential 9.9
35 osteoporosis 9.9
36 ovarian cancer 9.9
37 nephrolithiasis, calcium oxalate 9.9
38 rheumatoid arthritis 9.9
39 schizophrenia 9.9
40 tobacco addiction 9.9
41 lipoid congenital adrenal hyperplasia 9.9
42 diabetes mellitus, insulin-dependent 9.9
43 periodontitis, chronic 9.9
44 aarskog-scott syndrome 9.9
45 muscular dystrophy, duchenne type 9.9
46 dermatitis, atopic 9.9
47 pulmonary disease, chronic obstructive 9.9
48 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
49 smoking as a quantitative trait locus 3 9.9
50 inflammatory bowel disease 9.9

Graphical network of the top 20 diseases related to Taqi Polymorphism:



Diseases related to Taqi Polymorphism

Symptoms & Phenotypes for Taqi Polymorphism

Clinical features from OMIM:

313480

GenomeRNAi Phenotypes related to Taqi Polymorphism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 LDLR UPK1B

MGI Mouse Phenotypes related to Taqi Polymorphism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 CCNA2 DRD2 FGA IL12B INHBA LDLR
2 digestive/alimentary MP:0005381 9.87 DRD2 FGA IL12B INHBA LDLR TGFA
3 immune system MP:0005387 9.81 CCNA2 DRD2 FGA IL12B LDLR REN
4 integument MP:0010771 9.5 DRD2 FGA GCDH INHBA LDLR TGFA
5 muscle MP:0005369 9.17 ACTA2 DRD2 INHBA LDLR REN TGFA

Drugs & Therapeutics for Taqi Polymorphism

Drugs for Taqi Polymorphism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
2
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
3
Vitamin D3 Approved, Nutraceutical Phase 2 67-97-0 6221 5280795
4
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
5 Vitamins Phase 2
6 Trace Elements Phase 2
7 Nutrients Phase 2
8 Micronutrients Phase 2
9 Ergocalciferols Phase 2
10 Vitamin D2 Phase 2
11 Calciferol Phase 2
12 Calcium, Dietary Phase 2
13 Hormones Phase 2
14
Methylcobalamin Approved, Investigational 13422-55-4
15
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
16
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
17
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
18
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
19
Cobalamin Experimental 13408-78-1 6857388
20 Hematinics
21 Vitamin B 12
22 Vitamin B9
23 retinol
24 Vitamin B Complex
25 Retinol palmitate
26 Vitamin B12
27 Folate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II RCT of High-dose Vitamin D Supplements in Older Adults Recruiting NCT03613116 Phase 2
2 Practice Based Nutrition Intervention-2 Completed NCT01700868
3 A Nutritional Intervention for Diabetic Neuropathy Completed NCT01690962
4 A Nutritional Intervention for Diabetic Neuropathy (WCCR-DN2) Completed NCT01953757

Search NIH Clinical Center for Taqi Polymorphism

Genetic Tests for Taqi Polymorphism

Anatomical Context for Taqi Polymorphism

MalaCards organs/tissues related to Taqi Polymorphism:

40
Breast, Bone, T Cells, Prostate, Kidney, Brain, Liver

Publications for Taqi Polymorphism

Articles related to Taqi Polymorphism:

(show top 50) (show all 458)
# Title Authors PMID Year
1
Single-copy sequence hybridizes to polymorphic and homologous loci on human X and Y chromosomes. 56
6291041 1982
2
VDR Gene Polymorphisms and Allergic Diseases: Evidence from a Meta-analysis. 61
31752548 2020
3
The influence of polymorphisms of fat mass and obesity (FTO, rs9939609) and vitamin D receptor (VDR, BsmI, TaqI, ApaI, FokI) genes on weight loss by diet and exercise interventions in non-diabetic overweight/obese Asian Indians in North India. 61
32001813 2020
4
Association between vitamin D receptor gene FokI and TaqI variants with autism spectrum disorder predisposition in Iranian population. 61
31589956 2020
5
The possible role of maternal and placental vitamin D receptor polymorphisms and haplotypes in pathogenesis of preeclampsia. 61
31006279 2020
6
Association of vitamin D receptor TaqI and ApaI genetic polymorphisms with nephrolithiasis and end stage renal disease: a meta-analysis. 61
31822280 2019
7
Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis. 61
31878897 2019
8
Vitamin D Receptor Polymorphisms Associated with Susceptibility to Obesity: A Meta-Analysis. 61
31682593 2019
9
Association of select vitamin D receptor gene polymorphisms with the risk of tobacco-related cancers - a meta-analysis. 61
31690771 2019
10
Matrix metalloprotease-9 polymorphism and its association with Atherosclerosis - A case-control study in Pakistani population. 61
31622289 2019
11
Levels of Vitamin D Are Low After Crohn's Disease Is Established But Not Before. 61
31589971 2019
12
Genetic variation in the maternal vitamin D receptor FokI gene as a risk factor for recurrent pregnancy loss. 61
31446814 2019
13
Vitamin D receptor ApaI (rs7975232), BsmI (rs1544410), Fok1 (rs2228570), and TaqI (rs731236) gene polymorphisms and susceptibility to pulmonary tuberculosis in an Iranian population: A systematic review and meta-analysis. 61
31740220 2019
14
Association between vitamin D receptor gene polymorphisms and Graves' disease: a systematic review and meta-analysis. 61
30924084 2019
15
Association of vitamin D receptor polymorphisms and nephrolithiasis: A meta-analysis. 61
31212049 2019
16
Association of Vitamin D Receptor Gene Polymorphisms and the Risk of Multiple Sclerosis: A Meta Analysis. 61
31677540 2019
17
Impact of vitamin D and vitamin D receptor TaqI polymorphism in primary human myoblasts. 61
31252402 2019
18
Genetic Variations in VDR could Modulate the Efficacy of Vitamin D3 Supplementation on Inflammatory Markers and Total Antioxidant Capacity among Breast Cancer Women: A Randomized Double Blind Controlled Trial. 61
31350967 2019
19
Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility: an updated meta-analysis. 61
30474246 2019
20
Vitamin D receptor (VDR) TaqI polymorphism, vitamin D and bone mineral density in patients with inflammatory bowel diseases. 61
30929318 2019
21
Vitamin D Receptor gene polymorphisms and plasma levels are associated with lumbar disc degeneration. 61
31127184 2019
22
Vitamin D status and vitamin D receptor gene polymorphism in Saudi children with acute lower respiratory tract infection. 61
30721418 2019
23
The effect of VDR gene polymorphisms and vitamin D level on blood pressure, risk of preeclampsia, gestational age, and body mass index. 61
30417411 2019
24
Vitamin D receptor gene polymorphisms and 25(OH) vitamin D: Lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients. 61
30555790 2019
25
Association of vitamin D receptor gene FokI and TaqI polymorphisms and risk of RDS. 61
30760068 2019
26
Positive correlation between vitamin D receptor gene TaqI variant and gastric cancer predisposition in a sample of Iranian population. 61
30666644 2019
27
Association of vitamin D binding protein and vitamin D receptor gene polymorphisms in Iranian patients with chronic periodontitis. 61
30083974 2019
28
Human host defence peptide LL37 and anti-cyclic citrullinated peptide antibody in early inflammatory arthritis. 61
31245047 2019
29
An association study of dopaminergic (DRD2) and serotoninergic (5-HT2) gene polymorphism and schizophrenia in a North Indian population. 61
30389402 2019
30
Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis. 61
31333781 2019
31
Vitamin D Receptor Gene Polymorphism In Chronic Telogen Effluvium; A Case-Control Study. 61
31632122 2019
32
Axonal degeneration in Parkinson's disease - Basal ganglia circuitry and D2 receptor availability. 61
31254937 2019
33
Vitamin D receptor gene polymorphisms (Apa1 and Taq1) in temporomandibular joint internal derangement/osteoarthritis in a group of Turkish patients. 61
30155592 2018
34
Molecular characterization of Aspergilli isolated from outdoor air. 61
30292392 2018
35
Variability of contribution of vitamin D receptor gene polymorphisms to outcome of HLA-matched sibling allogeneic bone marrow transplantation. 61
29972092 2018
36
No Association between Polymorphisms of Vitamin D and Oxytocin Receptor Genes and Autistic Spectrum Disorder in a Sample of Turkish Children. 61
30466214 2018
37
VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population. 61
30481178 2018
38
Positive correlation between vitamin D receptor gene FokI polymorphism and colorectal cancer susceptibility in South-Khorasan of Iran. 61
29953646 2018
39
The Allele 2 of the VNTR Polymorphism in the Gene That Encodes a Natural Inhibitor of IL-1β, IL-1RA Is Favorably Associated With Chronic Otitis Media. 61
29433161 2018
40
Vitamin D receptor variants and uncontrolled asthma. 61
29384117 2018
41
Mycosis Fungoides and Vitamin D Status: Analyses of Serum 25-Hydroxyvitamin D Levels and Single Nucleotide Polymorphisms in the Vitamin D Receptor Gene. 61
29782293 2018
42
Influence of Vitamin D Receptor Gene Polymorphisms on Response to Pegylated Interferon in Chronic Hepatitis B Egyptian Patients. 61
29766002 2018
43
An Evolutionary/Biochemical Connection between Promoter- and Primer-Dependent Polymerases Revealed by Systematic Evolution of Ligands by Exponential Enrichment. 61
29339418 2018
44
Association of dopamine receptor D2 gene (DRD2) Taq1 polymorphisms with eating behaviors and obesity among Chinese and Indian Malaysian university students. 61
29737821 2018
45
Association of toll-like receptors2 and 6 polymorphism with clinical mastitis and production traits in Holstein cattle. 61
30349567 2018
46
[The impact of VDR gene polymorphisms on obesity, metabolic changes, bone mass disorders and neoplastic processes]. 61
30300431 2018
47
The Association of Vitamin D Receptor Gene Polymorphism with Lung Cancer Risk: An Update Meta-analysis. 61
30686249 2018
48
Low genetic diversity of the Human T-cell Lymphotropic Virus (HTLV-1) in an endemic area of the Brazilian Amazon basin. 61
29558516 2018
49
Vitamin D receptor rs2228570 polymorphism is associated with LH levels in men exposed to anabolic androgenic steroids. 61
29351807 2018
50
Vitamin D Receptor TaqI Polymorphism Is Associated With Reduced Follicle Number in Women Utilizing Assisted Reproductive Technologies. 61
29892263 2018

Variations for Taqi Polymorphism

Expression for Taqi Polymorphism

Search GEO for disease gene expression data for Taqi Polymorphism.

Pathways for Taqi Polymorphism

Pathways related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.92 DRD2 ANKK1

GO Terms for Taqi Polymorphism

Cellular components related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 VDR LDLR IL12B

Biological processes related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.56 VDR LDLR INHBA ACTA2
2 response to drug GO:0042493 9.46 TGFA REN INHBA DRD2
3 long-term memory GO:0007616 9.32 LDLR DRD2
4 drinking behavior GO:0042756 8.96 REN DRD2
5 regulation of MAPK cascade GO:0043408 8.8 REN INHBA DRD2

Molecular functions related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 TGFA INHBA IL12B
2 signaling receptor binding GO:0005102 8.92 REN INHBA FGA DRD2

Sources for Taqi Polymorphism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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