Aliases & Classifications for Taqi Polymorphism

MalaCards integrated aliases for Taqi Polymorphism:

Name: Taqi Polymorphism 57
Taq1 57

External Ids:

OMIM 57 313480

Summaries for Taqi Polymorphism

MalaCards based summary : Taqi Polymorphism, also known as taq1, is related to impulse control disorder and heroin dependence. An important gene associated with Taqi Polymorphism is VDR (Vitamin D Receptor), and among its related pathways/superpathways is Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Bupropion and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and prostate, and related phenotypes are Increased LDL uptake and cardiovascular system

Description from OMIM: 313480

Related Diseases for Taqi Polymorphism

Graphical network of the top 20 diseases related to Taqi Polymorphism:



Diseases related to Taqi Polymorphism

Symptoms & Phenotypes for Taqi Polymorphism

Clinical features from OMIM:

313480

GenomeRNAi Phenotypes related to Taqi Polymorphism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 LDLR UPK1B

MGI Mouse Phenotypes related to Taqi Polymorphism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 ACTA2 DRD2 FGA LDLR REN TGFA
2 digestive/alimentary MP:0005381 9.8 DRD2 FGA IL12B INHBA LDLR TGFA
3 hematopoietic system MP:0005397 9.76 CCNA2 DRD2 FGA IL12B INHBA LDLR
4 immune system MP:0005387 9.56 CCNA2 DRD2 FGA IL12B LDLR REN
5 muscle MP:0005369 9.17 LDLR REN TGFA VDR ACTA2 DRD2

Drugs & Therapeutics for Taqi Polymorphism

Drugs for Taqi Polymorphism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3 Raclopride Investigational Phase 4 84225-95-6
4 Antidepressive Agents Phase 4
5 Antidepressive Agents, Second-Generation Phase 4
6 Autonomic Agents Phase 4
7 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
8 Cytochrome P-450 Enzyme Inhibitors Phase 4
9 Dopamine Agents Phase 4
10 Dopamine Uptake Inhibitors Phase 4
11 Neurotransmitter Agents Phase 4
12 Neurotransmitter Uptake Inhibitors Phase 4
13 Peripheral Nervous System Agents Phase 4
14 Protective Agents Phase 4
15 Psychotropic Drugs Phase 4
16
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
17
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
18 Bone Density Conservation Agents
19 Dihydroxycholecalciferols
20 Ergocalciferols
21 Micronutrients
22 Trace Elements
23 Vitamins
24 Calciferol Nutraceutical
25 Vitamin D2 Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 PET Imaging Study on Occupancy of Dopamine D2 Receptors and Genotypes After Bupropion Administration Completed NCT00846339 Phase 4 Bupropion
2 Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma Completed NCT02539745
3 Cognitive Processes Study in Obese Women With and Without Eating Disorders Completed NCT01948414 Not Applicable
4 Practice Based Nutrition Intervention-2 Completed NCT01700868 Not Applicable
5 RISSCI-1 Blood Cholesterol Response Study Recruiting NCT03270527 Not Applicable
6 Brain-to-Society Diagnostic for Prevention of Childhood Obesity and Chronic Disease Active, not recruiting NCT03151694
7 Plant-Based Dietary Intervention in Type 2 Diabetes-2 Suspended NCT01931631 Not Applicable

Search NIH Clinical Center for Taqi Polymorphism

Genetic Tests for Taqi Polymorphism

Anatomical Context for Taqi Polymorphism

MalaCards organs/tissues related to Taqi Polymorphism:

41
Bone, Brain, Prostate, Smooth Muscle

Publications for Taqi Polymorphism

Articles related to Taqi Polymorphism:

(show all 47)
# Title Authors Year
1
Association of VDR gene TaqI polymorphism with the susceptibility to prostate cancer in Asian population evaluated by an updated systematic meta-analysis. ( 29910622 )
2018
2
Association Study of Transforming Growth Factor Alpha TaqI Polymorphism and the Risk of Cleft Lip and/or Palate in an Iranian Population. ( 29105380 )
2017
3
Vitamin D Receptor Gene BSMI, FOKI, APAI, and TAQI Polymorphisms and the Risk of Atopic Dermatitis. ( 27164626 )
2016
4
VitaminA D receptor FokI, BsmI, and TaqI polymorphisms and susceptibility to rheumatoid arthritis : A meta-analysis. ( 26358095 )
2016
5
BsmI, ApaI and TaqI Polymorphisms in the Vitamin D Receptor Gene (VDR) and Association with Lumbar Spine Pathologies: An Italian Case-Control Study. ( 27149110 )
2016
6
A novel TaqI polymorphism in the coding region of the ovine TNXB gene in the MHC class III region: morphostructural and physiological influences. ( 23877191 )
2014
7
TaqI polymorphism of VDR gene contributes to breast cancer risk. ( 23904261 )
2014
8
Vitamin Da8^receptor FokI, BsmI, ApaI, and TaqI polymorphisms and the susceptibility to breast cancer: aa8^meta-analysis. ( 25244980 )
2014
9
Lack of association between vitamin D receptor gene ApaI, BsmI, and TaqI polymorphisms and primary biliary cirrhosis risk: a meta-analysis. ( 24526415 )
2014
10
Vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus. ( 23065277 )
2013
11
Association between vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus: a meta-analysis. ( 24212677 )
2013
12
ApaI, BsmI, FokI and TaqI polymorphisms in the vitamin D receptor (VDR) gene and the risk of psoriasis: a meta-analysis. ( 22540341 )
2013
13
VDR TaqI polymorphism is associated with chronic periodontitis in Italian population. ( 21764034 )
2011
14
Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients. ( 21538164 )
2011
15
Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism. ( 21168462 )
2011
16
Detection of VDR gene ApaI and TaqI polymorphisms in patients with type 2 diabetes mellitus using PCR-RFLP method in a Turkish population. ( 19186074 )
2010
17
Frequency of fokI and taqI polymorphism of vitamin D receptor gene in Indian population and its association with 25-hydroxyvitamin D levels. ( 21088715 )
2009
18
[Association between the TaqI polymorphism of the vitamin D receptor gene and lepromatous leprosy in a Mexican population sample]. ( 19180314 )
2009
19
Linkage and association of DRD2 gene TaqI polymorphism with schizophrenia in an Iranian population. ( 18426314 )
2008
20
Strong association of the renin TaqI polymorphism with essential hypertension in Chinese Han and Tibetan populations. ( 17476284 )
2007
21
DRD2/ANKK1 TaqI polymorphism and smoking behavior of Egyptian male cigarette smokers. ( 18058350 )
2007
22
Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis. ( 16769262 )
2006
23
Interaction of TaqI polymorphism at exon 9 of the vitamin D receptor gene with the negative lepromin response may favor the occurrence of leprosy. ( 16965356 )
2006
24
An affected pedigree member analysis of linkage between the dopamine D2 receptor gene TaqI polymorphism and obesity and hypertension. ( 15939106 )
2005
25
A TaqI polymorphism in the 3'UTR of the IL-12 p40 gene correlates with increased IL-12 secretion. ( 12424624 )
2002
26
Association of human cholesteryl ester transfer protein-TaqI polymorphisms with serum HDL cholesterol levels in a normolipemic Japanese rural population. ( 12033532 )
2002
27
Nature of the fibrinogen Aalpha gene TaqI polymorphism. ( 11583334 )
2001
28
Stress as a mediating factor in the association between the DRD2 TaqI polymorphism and alcoholism. ( 11331109 )
2001
29
Relationships between the taqI polymorphism of the dopamine D2 receptor and blood pressure in hyperglycaemic and normoglycaemic Chinese subjects. ( 11894971 )
2001
30
Modulation of blood pressure and obesity with the dopamine D2 receptor gene TaqI polymorphism. ( 10948074 )
2000
31
Familial calcium stone disease: TaqI polymorphism and the vitamin D receptor. ( 10405913 )
1999
32
The DRD2 TaqI polymorphism and symptoms of attention deficit hyperactivity disorder. ( 10578241 )
1999
33
A TaqI polymorphism in the chicken interferon regulatory factor 1 (IRF1) gene provides evidence that chicken linkage group E48C28W13 represents one of the microchromosomes. ( 10380694 )
1999
34
TaqI polymorphic sites at the human dopamine beta-hydroxylase gene possibly associated with biochemical alterations of the catecholamine pathway in schizophrenia. ( 9564683 )
1998
35
TaqI polymorphism in the 3' flanking region of the PI gene among Kuwaiti Arabs and Russians. ( 9160183 )
1997
36
Chromosomal localization of the human urothelial 'tetraspan' gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism. ( 9073521 )
1997
37
Association study of transforming growth factor alpha (TGF alpha) TaqI polymorphism and oral clefts: indication of gene-environment interaction in a population-based sample of infants with birth defects. ( 7702037 )
1995
38
A TaqI polymorphism in the human erythroid beta spectrin gene. ( 7868137 )
1995
39
TaqI polymorphism in intron 2 of the GCDH gene. ( 8069322 )
1994
40
Sequence correction and reassignment of the TaqI polymorphic site in the human inter-gamma-globin gene region, an African-specific marker. ( 8194849 )
1994
41
Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions. ( 8100397 )
1993
42
TaqI polymorphisms at the annexin VIII locus (ANX8). ( 1364010 )
1992
43
Identification of TaqI polymorphism in the mitochondrial acetoacetyl-CoA thiolase gene and familial analysis of 3-ketothiolase deficiency. ( 1362557 )
1992
44
A TaqI polymorphism at the ovine beta A-inhibin (INHBA) locus. ( 1503266 )
1992
45
A TaqI polymorphism in the human cyclin A gene. ( 1675006 )
1991
46
TaqI polymorphism in the 3' flanking region of the human aortic smooth muscle actin gene. ( 1969628 )
1990
47
TaqI polymorphism in the LDL receptor gene and a TaqI 1.5-kb band associated with familial hypercholesterolemia. ( 2901393 )
1988

Variations for Taqi Polymorphism

Expression for Taqi Polymorphism

Search GEO for disease gene expression data for Taqi Polymorphism.

Pathways for Taqi Polymorphism

Pathways related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.21 CCNA2 VDR

GO Terms for Taqi Polymorphism

Cellular components related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 ACTA2 FGA IL12B INHBA LDLR REN

Biological processes related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.46 ACTA2 INHBA LDLR VDR
2 long-term memory GO:0007616 9.26 DRD2 LDLR
3 response to drug GO:0042493 9.26 DRD2 INHBA REN TGFA
4 regulation of MAPK cascade GO:0043408 8.8 DRD2 INHBA REN

Molecular functions related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL12B INHBA TGFA
2 signaling receptor binding GO:0005102 8.92 DRD2 FGA INHBA REN

Sources for Taqi Polymorphism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....