TAQ1
MCID: TQP001
MIFTS: 35

Taqi Polymorphism (TAQ1)

Aliases & Classifications for Taqi Polymorphism

MalaCards integrated aliases for Taqi Polymorphism:

Name: Taqi Polymorphism 58
Taq1 58

External Ids:

OMIM 58 313480

Summaries for Taqi Polymorphism

MalaCards based summary : Taqi Polymorphism, also known as taq1, is related to impulse control disorder and heroin dependence. An important gene associated with Taqi Polymorphism is VDR (Vitamin D Receptor), and among its related pathways/superpathways is Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Dopamine and Bupropion have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and kidney, and related phenotypes are Increased LDL uptake and cardiovascular system

Description from OMIM: 313480

Related Diseases for Taqi Polymorphism

Diseases related to Taqi Polymorphism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 impulse control disorder 10.2 ANKK1 DRD2
2 heroin dependence 10.2 ANKK1 DRD2
3 alexithymia 10.2 ANKK1 DRD2
4 antisocial personality disorder 10.2 ANKK1 DRD2
5 arteries, anomalies of 10.1
6 multiple sclerosis 10.1
7 coronary artery anomaly 10.1
8 breast cancer 10.0
9 systemic lupus erythematosus 10.0
10 schizophrenia 10.0
11 lupus erythematosus 10.0
12 colorectal cancer 10.0
13 ataxia-telangiectasia 10.0
14 osteoarthritis 10.0
15 restless legs syndrome 10.0
16 telangiectasis 10.0
17 periodontal disease 10.0
18 alzheimer disease 9.8
19 biliary cirrhosis, primary, 1 9.8
20 attention deficit-hyperactivity disorder 9.8
21 hypercholesterolemia, familial 9.8
22 hypertension, essential 9.8
23 prostate cancer 9.8
24 rheumatoid arthritis 9.8
25 periodontitis, chronic 9.8
26 aarskog-scott syndrome 9.8
27 muscular dystrophy, duchenne type 9.8
28 prostate cancer, hereditary, 8 9.8
29 dermatitis, atopic 9.8
30 prostate cancer, hereditary, 6 9.8
31 arthritis 9.8
32 diabetes mellitus 9.8
33 pol iii-related leukodystrophies 9.8
34 primary biliary cirrhosis 9.8
35 polycystic kidney disease 9.8
36 lepromatous leprosy 9.8
37 melanoma 9.8
38 dermatitis 9.8
39 kidney disease 9.8
40 thyroid hyalinizing trabecular adenoma 9.8
41 periodontitis 9.8
42 psoriasis 9.8
43 cleft lip 9.8
44 muscular dystrophy 9.8
45 primary biliary cholangitis 9.8
46 idiopathic hypercalciuria 9.8 REN VDR
47 mineral metabolism disease 9.8 REN VDR
48 vesicoureteral reflux 1 9.5 REN UPK1B

Graphical network of the top 20 diseases related to Taqi Polymorphism:



Diseases related to Taqi Polymorphism

Symptoms & Phenotypes for Taqi Polymorphism

Clinical features from OMIM:

313480

GenomeRNAi Phenotypes related to Taqi Polymorphism according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 LDLR UPK1B

MGI Mouse Phenotypes related to Taqi Polymorphism:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ACTA2 DRD2 FGA LDLR REN TGFA
2 digestive/alimentary MP:0005381 9.87 DRD2 FGA IL12B INHBA LDLR TGFA
3 hematopoietic system MP:0005397 9.86 CCNA2 DRD2 FGA IL12B INHBA LDLR
4 immune system MP:0005387 9.76 CCNA2 DRD2 FGA IL12B LDLR REN
5 integument MP:0010771 9.43 DRD2 FGA INHBA LDLR TGFA VDR
6 muscle MP:0005369 9.17 ACTA2 DRD2 INHBA LDLR REN TGFA

Drugs & Therapeutics for Taqi Polymorphism

Drugs for Taqi Polymorphism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
2
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
3 Raclopride Investigational Phase 4 84225-95-6
4 Neurotransmitter Agents Phase 4
5 Neurotransmitter Uptake Inhibitors Phase 4
6 Dopamine Uptake Inhibitors Phase 4
7 Dopamine Agents Phase 4
8 Cytochrome P-450 Enzyme Inhibitors Phase 4
9 Protective Agents Phase 4
10 Cardiotonic Agents Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
13 Antidepressive Agents, Second-Generation Phase 4
14 Psychotropic Drugs Phase 4
15 Autonomic Agents Phase 4
16 Sympathomimetics Phase 4
17 Antidepressive Agents Phase 4
18
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
19
Calcium Approved, Nutraceutical Phase 1, Phase 2 7440-70-2 271
20
Calcitriol Approved, Nutraceutical Phase 1, Phase 2 32222-06-3 134070 5280453
21 Micronutrients Phase 1, Phase 2
22 Antineoplastic Agents, Alkylating Phase 1, Phase 2
23 Vitamins Phase 1, Phase 2
24 Vasoconstrictor Agents Phase 1, Phase 2
25 Hormones Phase 1, Phase 2
26 Alkylating Agents Phase 1, Phase 2
27 Bone Density Conservation Agents Phase 1, Phase 2
28 Trace Elements Phase 1, Phase 2
29 Calcium, Dietary Phase 1, Phase 2
30 Nutrients Phase 1, Phase 2
31
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
32
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
33 Vitamin D2
34 Dihydroxycholecalciferols
35 Calciferol
36 Ergocalciferols

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 PET Imaging Study on Occupancy of Dopamine D2 Receptors and Genotypes After Bupropion Administration Completed NCT00846339 Phase 4 Bupropion
2 Phase I/II Study of High-Dose Calcitriol Plus Temodar for Patients With Metastatic Melanoma Completed NCT00301067 Phase 1, Phase 2 Temozolomide
3 Brain-to-Society Diagnostic for Prevention of Childhood Obesity and Chronic Disease Unknown status NCT03151694
4 Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma Completed NCT02539745
5 Cognitive Processes Study in Obese Women With and Without Eating Disorders Completed NCT01948414 Not Applicable
6 Practice Based Nutrition Intervention-2 Completed NCT01700868 Not Applicable
7 RISSCI-1 Blood Cholesterol Response Study Recruiting NCT03270527 Not Applicable
8 Plant-Based Dietary Intervention in Type 2 Diabetes-2 Suspended NCT01931631 Not Applicable

Search NIH Clinical Center for Taqi Polymorphism

Genetic Tests for Taqi Polymorphism

Anatomical Context for Taqi Polymorphism

MalaCards organs/tissues related to Taqi Polymorphism:

42
Bone, Brain, Kidney, Endothelial, Prostate, Smooth Muscle

Publications for Taqi Polymorphism

Articles related to Taqi Polymorphism:

(show top 50) (show all 89)
# Title Authors Year
1
Association of VDR gene TaqI polymorphism with the susceptibility to prostate cancer in Asian population evaluated by an updated systematic meta-analysis. ( 29910622 )
2018
2
Vitamin D receptor gene polymorphisms (Apa1 and Taq1) in temporomandibular joint internal derangement/osteoarthritis in a group of Turkish patients. ( 30155592 )
2018
3
Association of dopamine receptor D2 gene (DRD2) Taq1 polymorphisms with eating behaviors and obesity among Chinese and Indian Malaysian university students. ( 29737821 )
2018
4
Association Study of Transforming Growth Factor Alpha TaqI Polymorphism and the Risk of Cleft Lip and/or Palate in an Iranian Population. ( 29105380 )
2017
5
Calcitonin Receptor AluI (rs1801197) and Taq1 Calcitonin Genes Polymorphism in 45-and Over 45-year-old Women and their Association with Bone Density. ( 27708484 )
2016
6
Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population. ( 27958635 )
2016
7
The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations' sex differences. ( 26217259 )
2015
8
A novel TaqI polymorphism in the coding region of the ovine TNXB gene in the MHC class III region: morphostructural and physiological influences. ( 23877191 )
2014
9
TaqI polymorphism of VDR gene contributes to breast cancer risk. ( 23904261 )
2014
10
VDR TaqI polymorphism is associated with chronic periodontitis in Italian population. ( 21764034 )
2011
11
Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism. ( 21168462 )
2011
12
Genetic variants at the APOE, lipoprotein lipase (LpL), cholesteryl ester transfer protein (CETP), and endothelial nitric oxide (eNOS) genes and coronary artery disease (CAD): CETP Taq1 B2B2 associates with lower risk of CAD in Asian Indians. ( 22460205 )
2010
13
Frequency of fokI and taqI polymorphism of vitamin D receptor gene in Indian population and its association with 25-hydroxyvitamin D levels. ( 21088715 )
2009
14
[Association between the TaqI polymorphism of the vitamin D receptor gene and lepromatous leprosy in a Mexican population sample]. ( 19180314 )
2009
15
Linkage and association of DRD2 gene TaqI polymorphism with schizophrenia in an Iranian population. ( 18426314 )
2008
16
Strong association of the renin TaqI polymorphism with essential hypertension in Chinese Han and Tibetan populations. ( 17476284 )
2007
17
DRD2/ANKK1 TaqI polymorphism and smoking behavior of Egyptian male cigarette smokers. ( 18058350 )
2007
18
Interaction of TaqI polymorphism at exon 9 of the vitamin D receptor gene with the negative lepromin response may favor the occurrence of leprosy. ( 16965356 )
2006
19
An affected pedigree member analysis of linkage between the dopamine D2 receptor gene TaqI polymorphism and obesity and hypertension. ( 15939106 )
2005
20
A TaqI polymorphism in the 3'UTR of the IL-12 p40 gene correlates with increased IL-12 secretion. ( 12424624 )
2002
21
Nature of the fibrinogen Aalpha gene TaqI polymorphism. ( 11583334 )
2001
22
Stress as a mediating factor in the association between the DRD2 TaqI polymorphism and alcoholism. ( 11331109 )
2001
23
Relationships between the taqI polymorphism of the dopamine D2 receptor and blood pressure in hyperglycaemic and normoglycaemic Chinese subjects. ( 11894971 )
2001
24
Association analysis for dopamine D2 receptor Taq1 polymorphism with P300 event-related potential for normal young females. ( 11702060 )
2001
25
Modulation of blood pressure and obesity with the dopamine D2 receptor gene TaqI polymorphism. ( 10948074 )
2000
26
Familial calcium stone disease: TaqI polymorphism and the vitamin D receptor. ( 10405913 )
1999
27
The DRD2 TaqI polymorphism and symptoms of attention deficit hyperactivity disorder. ( 10578241 )
1999
28
A TaqI polymorphism in the chicken interferon regulatory factor 1 (IRF1) gene provides evidence that chicken linkage group E48C28W13 represents one of the microchromosomes. ( 10380694 )
1999
29
Lack of correlation of free deoxypyridinoline excretion with Taq1 restriction length polymorphisms in the vitamin D receptor gene in males. ( 9641356 )
1998
30
TaqI polymorphism in the 3' flanking region of the PI gene among Kuwaiti Arabs and Russians. ( 9160183 )
1997
31
Chromosomal localization of the human urothelial 'tetraspan' gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism. ( 9073521 )
1997
32
TaqI polymorphism in Oct-1 in chickens. ( 9124723 )
1997
33
A high-frequency TaqI polymorphism at the ovine phenylalanine hydroxylase (PAH)locus. ( 8856909 )
1996
34
Association study of transforming growth factor alpha (TGF alpha) TaqI polymorphism and oral clefts: indication of gene-environment interaction in a population-based sample of infants with birth defects. ( 7702037 )
1995
35
A TaqI polymorphism in the human erythroid beta spectrin gene. ( 7868137 )
1995
36
PCR detection of the Taq1 restriction fragment length polymorphism linked to the ataxia telangiectasia locus. ( 7720261 )
1995
37
A TaqI polymorphism in a gene belonging to the human apoprotein(a)-plasminogen gene family on the telomeric region of chromosome 6 (6q26-27). ( 7554370 )
1995
38
An intragenic TaqI polymorphism in the faciogenital dysplasia (FGD1) locus, the gene responsible for Aarskog syndrome. ( 7557980 )
1995
39
A TaqI polymorphism at the porcine arachidonate 12-lipoxygenase (ALOX12) locus. ( 8572372 )
1995
40
TaqI polymorphism in intron 2 of the GCDH gene. ( 8069322 )
1994
41
A TaqI polymorphism in the bovine blood coagulation factor XIII a subunit gene. ( 7695131 )
1994
42
A compound TaqI polymorphism in sheep revealed by a carbonic anhydrase II (CA2) probe. ( 7818185 )
1994
43
A TaqI polymorphism at the beta-globin (HBB) locus in cattle. ( 7818188 )
1994
44
TaqI polymorphism of the human MXI1 gene. ( 7881441 )
1994
45
TaqI polymorphism of the human tissue inhibitor of metallo-proteinases-2 (Timp2) gene. ( 7909251 )
1994
46
A TaqI polymorphism at the immunoglobulin kappa light chain locus in Merino sheep. ( 8161025 )
1994
47
No effect of TaqI polymorphism at the human renal kallikrein (KLK1) locus on normal blood pressure level or variability. ( 7903227 )
1993
48
PA2.1 detects a TaqI polymorphism in the pseudoautosomal region. ( 8098984 )
1993
49
TaqI polymorphism in the human thyrotropin receptor gene (TSHR). ( 8102575 )
1993
50
The Y-specific p21A1/TaqI polymorphism occurs in four major population Oroups. ( 8514323 )
1993

Variations for Taqi Polymorphism

Expression for Taqi Polymorphism

Search GEO for disease gene expression data for Taqi Polymorphism.

Pathways for Taqi Polymorphism

Pathways related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.21 CCNA2 VDR

GO Terms for Taqi Polymorphism

Cellular components related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ACTA2 FGA IL12B INHBA REN TGFA
2 receptor complex GO:0043235 8.8 IL12B LDLR VDR

Biological processes related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.56 ACTA2 INHBA LDLR VDR
2 response to drug GO:0042493 9.46 DRD2 INHBA REN TGFA
3 long-term memory GO:0007616 9.32 DRD2 LDLR
4 drinking behavior GO:0042756 8.96 DRD2 REN
5 regulation of MAPK cascade GO:0043408 8.8 DRD2 INHBA REN

Molecular functions related to Taqi Polymorphism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL12B INHBA TGFA
2 signaling receptor binding GO:0005102 8.92 DRD2 FGA INHBA REN

Sources for Taqi Polymorphism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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