Aliases & Classifications for Tarsal Coalition

MalaCards integrated aliases for Tarsal Coalition:

Name: Tarsal Coalition 57
Tarsal Coalitions 29
Tarsal Fusion 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
tarsal coalition:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 186850
MedGen 41 C0265654
SNOMED-CT via HPO 68 263681008 27173008

Summaries for Tarsal Coalition

OMIM® : 57 Tarsal coalition is a fibrous, cartilaginous, or osseous union of two or more tarsal bones and is of congenital origin. Calcaneonavicular and middle-facet talocalcaneal coalitions are the most common (summary by Mosier and Asher, 1984). (186850) (Updated 05-Apr-2021)

MalaCards based summary : Tarsal Coalition, also known as tarsal coalitions, is related to osebold-remondini syndrome and cardiospondylocarpofacial syndrome. An important gene associated with Tarsal Coalition is FGFR3 (Fibroblast Growth Factor Receptor 3). The drugs Clonidine and Adrenergic alpha-Agonists have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related phenotype is tarsal synostosis.

Wikipedia : 73 Tarsal coalition is an abnormal connecting bridge of tissue between two normally-separate tarsal bones.... more...

Related Diseases for Tarsal Coalition

Graphical network of the top 20 diseases related to Tarsal Coalition:



Diseases related to Tarsal Coalition

Symptoms & Phenotypes for Tarsal Coalition

Human phenotypes related to Tarsal Coalition:

31
# Description HPO Frequency HPO Source Accession
1 tarsal synostosis 31 HP:0008368

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Limbs:
tarsal bone fusion
no carpal fusion

Clinical features from OMIM®:

186850 (Updated 05-Apr-2021)

Drugs & Therapeutics for Tarsal Coalition

Drugs for Tarsal Coalition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 4 4205-90-7 2803
2 Adrenergic alpha-Agonists Phase 4
3 Antihypertensive Agents Phase 4
4 Pharmaceutical Solutions Phase 4
5 Adrenergic Agents Phase 4
6 Neurotransmitter Agents Phase 4
7 Sympatholytics Phase 4
8 Analgesics Phase 4
9 Adrenergic Agonists Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clonidine for Tourniquet-related Pain in Children: A Pilot Study Not yet recruiting NCT04564430 Phase 4 Catapresan

Search NIH Clinical Center for Tarsal Coalition

Genetic Tests for Tarsal Coalition

Genetic tests related to Tarsal Coalition:

# Genetic test Affiliating Genes
1 Tarsal Coalitions 29

Anatomical Context for Tarsal Coalition

MalaCards organs/tissues related to Tarsal Coalition:

40
Bone, Bone Marrow, Skin

Publications for Tarsal Coalition

Articles related to Tarsal Coalition:

(show top 50) (show all 304)
# Title Authors PMID Year
1
The inheritance of tarsal coalition and its relationship to spastic flat foot. 57 61
4421359 1974
2
Tarsal coalitions and peroneal spastic flat foot. A review. 57
6480656 1984
3
Sustentaculum Tali Fracture Adjacent to Talocalcaneal Tarsal Coalitions: A Report of 2 Cases. 61
33760763 2021
4
The C-sign in normal feet: a prospective study and novel imaging algorithm for subtalar joint tarsal coalition. 61
33453609 2021
5
Tarsal Coalition of the Cuneiforms in a Young Athlete: A Case Report. 61
33502134 2021
6
Incidence of Symptomatic Pediatric Tarsal Coalition in Olmsted County: A Population-Based Study. 61
33186000 2021
7
Characteristics and reoperation rates of paediatric tarsal coalitions: a population-based study. 61
33343749 2020
8
Radiological findings of fibrocartilaginous coalition of the third tarsometatarsal joint: a retrospective cross-sectional study with computed tomography and magnetic resonance imaging. 61
32075412 2020
9
Endoscopic resection of the calcaneonavicular coalition. 61
32792286 2020
10
Bone scan with SPECT/CT in children with complex foot and ankle pain: Initial experience of a paediatric tertiary referral centre. 61
33204351 2020
11
Post-operative outcomes of arthroscopic tarsal coalition resection: A systematic review. 61
33029041 2020
12
Unsuspected tarsal coalitions in equinus and varus foot deformities. 61
31503103 2020
13
Ankle Ganglion Associated with Tarsal Coalition: A Case Report with a 5-Year Follow-up. 61
32773700 2020
14
A Rare Case of Symptomatic Planovalgus Foot with Triple Coalition. 61
33623763 2020
15
Tarsal tunnel syndrome caused by posterior facet talocalcaneal coalition: A case report. 61
32590797 2020
16
Correlation between the accessory anterolateral talar facet, bone marrow edema, and tarsal coalitions. 61
31781788 2020
17
Endoscopic Approach to Posterior Ankle via Lateral Portals. 61
32368479 2020
18
Diagnosing tarsal coalition in medieval Exeter. 61
31911394 2020
19
One-Bone Tarsus: A Case Report. 61
32131007 2020
20
Accessory anterolateral talar facet associated with tarsal coalition: prevalence and cross-sectional characterization. 61
31402414 2020
21
Tarsal coalition. 61
31789975 2020
22
The natural course of pain in patients with symptomatic tarsal coalitions: A retrospective clinical study. 61
30926227 2020
23
Surgical treatment of tarsal coalitions in children and adolescents. 61
32175094 2020
24
Excision of a Middle Facet Tarsal Coalition. 61
32368410 2020
25
[CT imaging features and misdiagnosis analysis of occult anterior calcaneal process fracture]. 61
31870057 2019
26
Functional and Radiological Outcomes After Tarsal Coalition Resections: A Minimum 5-Year Follow-Up. 61
31679676 2019
27
Normal Variations and Pathologic Disorders of Chondrification and Ossification of the Foot and Related Diseases. 61
31556085 2019
28
Tarsal fusion for pes equinovarus deformity improves gait capacity in chronic stroke patients. 61
31375133 2019
29
Postaxial hypoplasia of the lower extremity (fibular hemimelia) presenting in a young adult male. 61
31236184 2019
30
Tibial spastic varus foot caused by os calcaneus secundarius: A case report. 61
30986662 2019
31
Realignment Calcaneal Osteotomy for Bilateral Complete Talocalcaneal Synostosis: A Case Report. 61
30914151 2019
32
Nonsyndromic Massive Tarsal and Tarsometatarsal Coalitions in a Young Female. 61
30902491 2019
33
Technique Article: Tarsal Coalition Resection Using Kirschner Wires Across the Subtalar Joint in a Two-Incision Approach. 61
30850103 2019
34
Bilateral Triple Talocalcaneal, Calcaneonavicular, and Talonavicular Tarsal Coalition: A Case Report. 61
30850104 2019
35
Occurrence of Lateral Ankle Ligament Disease With Stage 2 to 3 Adult-Acquired Flatfoot Deformity Confirmed via Magnetic Resonance Imaging: A Retrospective Study. 61
30583836 2019
36
Tarsal coalition in paediatric patients. 61
29601967 2019
37
Talocalcaneal Coalition Including Open Comminuted Calcaneal Fracture; A Case Report and Literature Review. 61
30719472 2019
38
Identification of a Novel NOG Missense Mutation in a Chinese Family With Symphalangism and Tarsal Coalitions. 61
31105738 2019
39
Treatment of isolated talonavicular coalition: Case report and literature review. 61
30453800 2018
40
Talar beak sign: Tarsal coalition. 61
30309072 2018
41
Rare Combination of a Cuboid-navicular Tarsal Coalition with a Closed Tibialis Anterior Tendon Rupture: A Case Report and Review of the Literature. 61
30740363 2018
42
Seven additional families with spondylocarpotarsal synostosis syndrome with novel biallelic deleterious variants in FLNB. 61
29566257 2018
43
High Rates of Psychiatric Disorders and Below Normal Mental Capacity Associated With Spastic Peroneal Flatfoot: A New Relationship. 61
29685560 2018
44
The "Double Medial Malleolus": A New Physical Finding in Talocalcaneal Coalition. 61
27261958 2018
45
Postaxial limb hypoplasia (PALH): the classification, clinical features, and related developmental biology. 61
28990185 2017
46
Lateral Ligament Reconstruction for Ball-and-Socket Ankle Accompanying Lateral Ankle Instability: A Case Report and Literature Review. 61
29079243 2017
47
Massive Osteochondral Lesion of the Talus in a Skeletally Immature Patient Associated With a Tarsal Coalition and Valgus Hindfoot. 61
28558999 2017
48
The role of arthroereisis of the subtalar joint for flatfoot in children and adults. 61
29218229 2017
49
Gait Analysis of Symptomatic Flatfoot in Children: An Observational Study. 61
28861205 2017
50
Bilateral tarsal tunnel syndrome attributed to bilateral fibrous tarsal coalition and symmetrical hypertrophy of the sustentaculum tali. 61
28883007 2017

Variations for Tarsal Coalition

Expression for Tarsal Coalition

Search GEO for disease gene expression data for Tarsal Coalition.

Pathways for Tarsal Coalition

GO Terms for Tarsal Coalition

Sources for Tarsal Coalition

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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