Tarsal Tunnel Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Tarsal tunnel syndrome is a nerve disorder that is characterized by pain in the ankle, foot, and toes. This condition is caused by compression of the posterior tibial nerve, which runs through a canal near the heel into the sole of the foot. When tissues around this nerve become inflamed, they can press on the nerve and cause the pain associated with Tarsal tunnel syndrome.

MalaCards based summary: Tarsal Tunnel Syndrome, also known as neuropathy of the posterior tibial nerve and its branches, is related to tibial neuropathy and nerve compression syndrome. An important gene associated with Tarsal Tunnel Syndrome is CCNL1 (Cyclin L1). Affiliated tissues include bone.

Wikipedia: ⁷⁵ Tarsal tunnel syndrome (TTS) is a compression neuropathy and painful foot condition in which the tibial... more...

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Related Diseases for Tarsal Tunnel Syndrome

Diseases related to Tarsal Tunnel Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)

#	Related Disease	Score	Top Affiliating Genes
1	tibial neuropathy	27.7	TNC SNORD22 PAGE2 MPZ MED31 GNPTG
2	nerve compression syndrome	10.9
3	neuropathy, hereditary, with liability to pressure palsies	10.8
4	neurilemmoma	10.7
5	paresthesia	10.6
6	neuropathy	10.5
7	carpal tunnel syndrome	10.5
8	varicose veins	10.5
9	mononeuropathy of the median nerve, mild	10.5
10	peripheral nervous system disease	10.5
11	tenosynovitis	10.5
12	exostosis	10.4
13	fasciitis	10.4
14	plantar fasciitis	10.4
15	tarsal coalition	10.4
16	radiculopathy	10.4
17	spondyloarthropathy 1	10.4
18	gout	10.4
19	synovitis	10.4
20	lipomatosis, multiple	10.3
21	neuritis	10.3
22	spondylitis	10.3
23	neurofibroma	10.3
24	osteochondroma	10.3
25	reflex sympathetic dystrophy	10.2
26	polyneuropathy	10.2
27	complex regional pain syndrome	10.2
28	pfeiffer syndrome	10.2
29	leprosy 3	10.2
30	sarcoma, synovial	10.2
31	microvascular complications of diabetes 1	10.2
32	muscle hypertrophy	10.2
33	tendinitis	10.2
34	sarcoma	10.2
35	diabetic polyneuropathy	10.2
36	hypothyroidism	10.2
37	neuroma	10.2
38	chronic kidney disease	10.2
39	diabetic neuropathy	10.2
40	synovial chondromatosis	10.2
41	epidural spinal canal neoplasm	10.0	PAGE2 ENTREP3
42	exostoses, multiple, type i	10.0
43	guillain-barre syndrome, familial	10.0
44	enchondromatosis, multiple, ollier type	10.0
45	osteoporosis	10.0
46	peroneal nerve, accessory deep	10.0
47	contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a	10.0
48	scleroderma, familial progressive	10.0
49	thrombophilia due to thrombin defect	10.0
50	down syndrome	10.0

Graphical network of the top 20 diseases related to Tarsal Tunnel Syndrome:

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Symptoms & Phenotypes for Tarsal Tunnel Syndrome

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Drugs & Therapeutics for Tarsal Tunnel Syndrome

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	What is the Relationship Between Tarsal Tunnel Syndrome and Foot Pain in Fibromyalgia Patients	Completed	NCT05135572
2	The Effectiveness of Tibial Nerve Mobilization in Patients With Tarsal Tunnel Syndrome	Completed	NCT05307354

Search NIH Clinical Center for Tarsal Tunnel Syndrome

Cochrane evidence based reviews: tarsal tunnel syndrome

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Genetic Tests for Tarsal Tunnel Syndrome

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Anatomical Context for Tarsal Tunnel Syndrome

Organs/tissues related to Tarsal Tunnel Syndrome:

MalaCards : Bone

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Publications for Tarsal Tunnel Syndrome

Articles related to Tarsal Tunnel Syndrome:

(show top 50) (show all 612)

#	Title	Authors	PMID	Year
1	An update on imaging of tarsal tunnel syndrome. ⁶²	Khodatars D...Saifuddin A	35562562	2022
2	Magnetic Resonance Imaging Findings in Patients with Tarsal Tunnel Syndrome. ⁶²	Kim K...Morita A	36184477	2022
3	Accessory slip of flexor digitorum accessorius (Quadratus plantae) muscle surrounding the lateral plantar nerve and vessels. ⁶²	Nayak SB...Vasudeva SK	34247922	2022
4	Mid-term functional outcomes following reoperation after total ankle arthroplasty: A retrospective cohort study. ⁶²	Kim J...Demetracopoulos C	36088242	2022
5	How Common is Subsequent Posterior Tibial Tendon Dysfunction or Tarsal Tunnel Syndrome After Ankle Sprain Injury? ⁶²	Foster KS...Rhon DI	35944572	2022
6	Radiofrequency Plantar Fascia Coblation With and Without Gastrocnemius Recession in the Management of Recalcitrant Plantar Fasciitis. ⁶²	Koh DTS...Yeo NEM	35652744	2022
7	[Plantar Fasciopathy - Pathophysiology Diagnostics and Therapy - A Clinical Guideline]. ⁶²	Hirschmuller A...Weidermann F	35983940	2022
8	Anatomy of the tibial nerve in relation to the tarsal tunnel: A cadaveric study. ⁶²	Mattos I...Kennedy JG	35985969	2022
9	An Experience With an Exoscope System (ORBEYE) for Surgery for Tarsal Tunnel Syndrome: A Case Report. ⁶²	Miura I...Kawamata T	36120253	2022
10	Retro-Malleolar Z-Plasty of Flexor Hallucis Longus Tendon in Post-Traumatic Checkrein Deformity: A Case Series and Literature Review. ⁶²	Polichetti C...Perisano C	36013539	2022
11	Predictive factors of effective tibial nerve release in tarsal tunnel syndrome. ⁶²	Bouysset M...Coury F	34246562	2022
12	Acute Tarsal Tunnel Syndrome After Total Ankle Arthroplasty With Varus Deformity. ⁶²	Obioha OA...Hamid KS	35821944	2022
13	[Clinical anatomical study on the treatment of tarsal tunnel syndrome with four-point vertical acupotomy]. ⁶²	Sun XJ...Li SL	35730224	2022
14	An unusual cause of tarsal tunnel syndrome: Schwannoma of the posterior tibial nerve; a rare cause and rare localization. ⁶²	Elghoul N...Bouabid SA	35803099	2022
15	Tarsal Tunnel Syndrome: An Ultrasound Pictorial Review. ⁶²	de Souza Reis Soares O...Brasseur JL	34342896	2022
16	Accessory Flexor Digitorum Longus Presenting as Tarsal Tunnel Syndrome: A Case Series. ⁶²	Parkhurst DB...Knake JJ	35316824	2022
17	Tarsal tunnel syndrome secondary to accessory or variant muscles: a clinical and anatomical systematic review. ⁶²	Yammine K...Assi C	35353216	2022
18	Tarsal Tunnel Syndrome: Outcome According to Etiology. ⁶²	Lalevee M...Bouysset M	34799273	2022
19	Avoidance of injury to the posterior neurovascular bundle during total ankle arthroplasty - A simple technical tip. ⁶²	Ramhamadany E...Blundell CM	35581124	2022
20	A retrospective magnetic resonance imaging analysis of bone and soft tissue changes associated with the spectrum of tarsal coalitions. ⁶²	Cilengir AH...Tosun O	35384073	2022
21	Patient reported outcomes following revision neurectomy through a dorsal approach for recurrent interdigital neuroma. ⁶²	Ettehadi H...Ferrao P	35393246	2022
22	Perioperative Complications and Adverse Events after Surgery for Peripheral Nerve- and Para-lumbar Spine Diseases. ⁶²	Kim K...Morita A	34759069	2022
23	Calcaneal osteotomy for hindfoot deformity. ⁶²	Brilhault J	34687951	2022
24	Previously Unreported Case of Variant Posterior Tibial Vein Forming a Loop Adjacent to the Posterior Tibial Artery. ⁶²	Terle PM...Tubbs RS	35340515	2022
25	The Course of Tarsal Tunnel Syndrome after Ultrasound-Guided Injections. ⁶²	Atesok K...Park J	35769651	2022
26	[An unusual cause of tarsal tunnel syndrome in a 15-year-old girl: about a case]. ⁶²	Abdelkrim EH...Najeb Y	36034033	2022
27	Iatrogenic nerve injury and foot drop: Surgical results in 28 patients. ⁶²	Nath RK...Somasundaram C	35855127	2022
28	Tarsal tunnel syndrome: Clinical-imaging analysis of a case series. ⁶²	Vargas Gallardo F...Fernandez Comber S	33947645	2022
29	An Update on Posterior Tarsal Tunnel Syndrome. ⁶²	Fortier LM...Kaye AD	35769658	2022
30	A Rare Case of Flexor Digitorum Accessorius Longus Muscle Presenting as Tarsal Tunnel Syndrome. ⁶²	Ettehadi H...Ferrao P	35291249	2022
31	Clinical Results Following Conservative Management of Tarsal Tunnel Syndrome Compared With Surgical Treatment: A Systematic Review. ⁶²	Vij N...Urits I	36072502	2022
32	Assessment of the frequency of tarsal tunnel syndrome in rheumatoid arthritis. ⁶²	Kalcik Unan M...Kamanli A	35141482	2021
33	Tarsal tunnel syndrome: current rationale, indications and results. ⁶²	Rodriguez-Merchan EC...Moracia-Ochagavia I	35839088	2021
34	Unusual bilateral variation of the flexor digitorum accessorius longus muscle and its relation on tarsal tunnel syndrome. ⁶²	Lin DC...Wisco JJ	34559293	2021
35	Tarsal tunnel syndrome due to talocalcaneal coalition. ⁶²	Park CH...Chang MC	34607407	2021
36	Can the axial cross-sectional area of the tibial nerve be used to diagnose tarsal tunnel syndrome? An ultrasonography study. ⁶²	Fantino O...Pialat JB	32682728	2021
37	A Minimally Invasive Full Endoscopic Approach to Tibial Nerve Neurolysis in Diabetic Foot Neuropathy: An Alternative to Open Procedures. ⁶²	Uemura T...Okutsu I	34432688	2021
38	Carpal, cubital or tarsal tunnel syndrome after SARS-CoV-2 infection: A causal link? ⁶²	Roncati L...Adani R	34217126	2021
39	Stingray-Induced Tarsal Tunnel Syndrome. ⁶²	Mix FM...Brooks JE	34513381	2021
40	Narrative review of ring fixator management of recurrent club foot deformity. ⁶²	Meyer Z...Riccio AI	34423016	2021
41	Ultrasound-Guided Near-Nerve Needle Sensory Technique for the Diagnosis of Tarsal Tunnel Syndrome. ⁶²	Vega-Zelaya L...Noriega C	34300231	2021
42	Endoscopic Ganglionectomy of the Tarsal Tunnel: A Medial Approach. ⁶²	Lui TH...Chan SK	34258212	2021
43	Quantitative study of PIMT technique aiming its validation as physical therapy procedure. ⁶²	Takahashi HA...Quevedo AAF	33957521	2021
44	Mal-union of sustentaculum tali fracture with talo-calcaneal coalition leading to tarsal tunnel syndrome: A case report. ⁶²	Moonot P...Kadakia AR	33964532	2021
45	Tarsal Tunnel Syndrome. ⁶²	Nelson SC	33745647	2021
46	Ultrasound-Guided Proximal and Distal Tarsal Decompression: An Analysis of Pressures in the Tarsal, Medial Plantar, and Lateral Plantar Tunnels. ⁶²	Iborra Marcos A...Zislis G	32088990	2021
47	Variable Branching Pattern of Tibial Nerve in the Tarsal Tunnel: A Gross Anatomical Study With Clinical Implications. ⁶²	Banik S...Guria LR	33717767	2021
48	Tarsal tunnel syndrome in patients with fibromyalgia. ⁶²	Jo YS...Na SJ	34046575	2021
49	Efficacy of a single botulinum toxin A injection for distal tarsal tunnel syndrome: A protocol for a randomized, double-blinded trial. ⁶²	Baarini O...Edwards SR	33553799	2021
50	Surgical efficacy analysis of tarsal tunnel syndrome: a retrospective study of 107 patients. ⁶²	Yu X...Liu P	33106965	2021

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Genes for Tarsal Tunnel Syndrome

Genes related to Tarsal Tunnel Syndrome (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCNL1	Cyclin L1	Protein Coding	5.51	DISEASES inferred ¹⁴
2	SNORD22	Small Nucleolar RNA, C/D Box 22	RNA Gene	5.31	DISEASES inferred ¹⁴
3	GNPTG	N-Acetylglucosamine-1-Phosphate Transferase Subunit Gamma	Protein Coding	5.2	DISEASES inferred ¹⁴
4	TNC	Tenascin C	Protein Coding	5.1	DISEASES inferred ¹⁴
5	PAGE2	PAGE Family Member 2	Protein Coding	4.94	DISEASES inferred ¹⁴
6	MPZ	Myelin Protein Zero	Protein Coding	4.82	DISEASES inferred ¹⁴
7	ENTREP3	Endosomal Transmembrane Epsin Interactor 3	Protein Coding	4.62	DISEASES inferred ¹⁴
8	ADAD2	Adenosine Deaminase Domain Containing 2	Protein Coding	4.49	DISEASES inferred ¹⁴
9	GNPTAB	N-Acetylglucosamine-1-Phosphate Transferase Subunits Alpha And Beta	Protein Coding	4.41	DISEASES inferred ¹⁴
10	MED31	Mediator Complex Subunit 31	Protein Coding	4.39	DISEASES inferred ¹⁴
11	GPRIN3	GPRIN Family Member 3	Protein Coding	4.38	DISEASES inferred ¹⁴

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Variations for Tarsal Tunnel Syndrome

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Expression for Tarsal Tunnel Syndrome

Search GEO for disease gene expression data for Tarsal Tunnel Syndrome.

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Pathways for Tarsal Tunnel Syndrome

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GO Terms for Tarsal Tunnel Syndrome

Biological processes related to Tarsal Tunnel Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	carbohydrate phosphorylation	GO:0046835	9.26	GNPTG GNPTAB
2	N-glycan processing to lysosome	GO:0016256	8.92	GNPTG GNPTAB

Molecular functions related to Tarsal Tunnel Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity	GO:0003976	8.92	GNPTG GNPTAB

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Sources for Tarsal Tunnel Syndrome

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: TRS001 MIFTS: 30	Tarsal Tunnel Syndrome Categories: Muscle diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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