MCID: TRD003
MIFTS: 33

Taurodontism

Categories: Rare diseases, Oral diseases

Aliases & Classifications for Taurodontism

MalaCards integrated aliases for Taurodontism:

Name: Taurodontism 57 76 53 59 29 55 73
Large Pulp Chambers in the Molars 53
Bull Teeth 53

Characteristics:

OMIM:

57
Inheritance:
? autosomal recessive
likely polygenic


Classifications:

Orphanet: 59  
Rare odontological diseases


External Ids:

OMIM 57 272700
Orphanet 59 ORPHA3289
MESH via Orphanet 45 C536946
UMLS via Orphanet 74 C0266039
ICD10 via Orphanet 34 K00.2
MedGen 42 C0266039
SNOMED-CT via HPO 69 51744007
UMLS 73 C0266039

Summaries for Taurodontism

NIH Rare Diseases : 53 Taurodontism is a disorder of tooth development and occurs most commonly in permanent molar teeth. It refers to an elongation of the pulp chamber of the tooth, which can cause the tooth to lie deep in the jaw (aveolar process). At this time the cause of taurodontism is unknown.

MalaCards based summary : Taurodontism, also known as large pulp chambers in the molars, is related to tooth agenesis and taurodontism, microdontia, and dens invaginatus. An important gene associated with Taurodontism is DLX3 (Distal-Less Homeobox 3). Affiliated tissues include bone, and related phenotypes are taurodontia and abnormality of dental enamel

Wikipedia : 76 Taurodontism is a condition found in the molar teeth of humans whereby the body of the tooth and pulp... more...

Description from OMIM: 272700

Related Diseases for Taurodontism

Graphical network of the top 20 diseases related to Taurodontism:



Diseases related to Taurodontism

Symptoms & Phenotypes for Taurodontism

Symptoms via clinical synopsis from OMIM:

57
Teeth:
taurodontism
large dental pulp chambers
root deep in alveolar bone


Clinical features from OMIM:

272700

Human phenotypes related to Taurodontism:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 taurodontia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000679
2 abnormality of dental enamel 59 32 occasional (7.5%) Occasional (29-5%) HP:0000682

GenomeRNAi Phenotypes related to Taurodontism according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.56 DLX3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.56 DLX3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.56 EDA
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.56 DLX3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.56 DLX3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.56 EDA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.56 EDA DLX3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.36 EDA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.36 DLX3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.36 DLX3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.36 DLX3 EDA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.36 EDA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.36 DLX3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.36 DLX3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.36 EDA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.36 EDA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.36 DLX3

Drugs & Therapeutics for Taurodontism

Search Clinical Trials , NIH Clinical Center for Taurodontism

Genetic Tests for Taurodontism

Genetic tests related to Taurodontism:

# Genetic test Affiliating Genes
1 Taurodontism 29

Anatomical Context for Taurodontism

MalaCards organs/tissues related to Taurodontism:

41
Bone

Publications for Taurodontism

Articles related to Taurodontism:

(show top 50) (show all 128)
# Title Authors Year
1
Extending Coronectomy Indications to Third Molars with Taurodontism to Prevent Paresthesia and Mandible Fracture. ( 29808127 )
2018
2
Endodontic management of taurodontism with a complex root canal anatomy in mandibular posterior teeth. ( 29269370 )
2017
3
A Rare Condition of Bimaxillary Primary Molar Taurodontism. ( 28620641 )
2017
4
Enamel Pit Defects and Taurodontism in a Patient with Ring Chromosome 14 and 47,XXX. ( 28387189 )
2017
5
Taurodontism, variations in tooth number, and misshapened crowns in Wnt10a null mice and human kindreds. ( 25629078 )
2015
6
Taurodontism in patients with nonsyndromic cleft lip and palate in a Brazilian population: a case control evaluation with panoramic radiographs. ( 26428895 )
2015
7
Taurodontism, Root Dilaceration, and Tooth Transposition: A Radiographic Study of a Population with Nonsyndromic Cleft Lip and/or Palate. ( 26247709 )
2015
8
Assessing the association of taurodontism with numeric dentition anomalies in an adult central Indian population. ( 25097429 )
2014
9
Interradicular dentin dysplasia associated with amelogenesis imperfecta with taurodontism or trichodentoosseous syndrome: a diagnostic dilemma. ( 24992867 )
2014
10
Treatment of a hypertaurodontic maxillary second molar in a patient with 10 taurodonts: a case report. ( 24332006 )
2014
11
Exploring the biomechanics of taurodontism. ( 25407030 )
2014
12
Taurodontism. ( 25210354 )
2014
13
Non syndromic familial bilateral decidious taurodontism - a first case report. ( 25654041 )
2014
14
Taurodontism: A dental rarity. ( 24574680 )
2013
15
Endodontic treatment of hypertaurodontism with multiple bilateral taurodontism. ( 24082583 )
2013
16
Managing a mandibular second premolar with three-canal and taurodontism: a case report. ( 23411506 )
2013
17
Taurodontism. ( 23598931 )
2013
18
Taurodontism in a central anatolian population. ( 23946746 )
2013
19
Taurodontism in deciduous molars. ( 23737594 )
2013
20
Biometric Analysis - A Reliable Indicator for Diagnosing Taurodontism using Panoramic Radiographs. ( 24086912 )
2013
21
Prevalence of taurodontism in the North Indian population. ( 24455077 )
2013
22
Taurodontism: A minor diagnostic criterion in Laurence-Moon/Bardet-Biedl syndromes. ( 23638763 )
2013
23
Bilateral taurodontism in primary dentition with hypodontia. ( 23345504 )
2013
24
Prevalence of taurodontism and its association with various oral conditions in an Indian population. ( 23534039 )
2013
25
Prevalence of taurodontism in primary mandibular first molars of ethnic Indian children. ( 23032243 )
2012
26
Oligodontia with taurodontism in monozygous twins. ( 23272313 )
2012
27
Prevalence of taurodontism in premolars and molars in the South of iran. ( 22991630 )
2012
28
Taurodontism in Brazilian patients with tooth agenesis and first and second-degree relatives: a case-control study. ( 22647425 )
2012
29
Side of dental anomalies and taurodontism as potential clinical markers for cleft subphenotypes. ( 20507240 )
2011
30
Taurodontism in children with hypodontia and supernumerary teeth: a case control study. ( 20483017 )
2010
31
Quantification of taurodontism: interests in the early diagnosis of hypohidrotic ectodermal dysplasia. ( 20374512 )
2010
32
Multiple bilateral taurodontism. A case report. ( 20951311 )
2010
33
Multiple taurodontism: the challenge of endodontic treatment. ( 21206170 )
2010
34
Taurodontism--a review. ( 19518034 )
2009
35
Assessing the proposed association between tooth agenesis and taurodontism in 975 paediatric subjects. ( 18384350 )
2008
36
Taurodontism and Van der Woude syndrome. Is there an association? ( 18298211 )
2008
37
Taurodontism: a review of the condition and endodontic treatment challenges. ( 18363703 )
2008
38
Severely hypoplastic amelogenesis imperfecta with taurodontism. ( 17559453 )
2007
39
Prevalence of taurodontism in premolars among patients at a tertiary care institution in Trinidad. ( 18198744 )
2007
40
Endodontic treatment of a taurodontism tooth: report of a case. ( 24454455 )
2006
41
Taurodontism of deciduous and permanent molars: report of two cases. ( 16582531 )
2006
42
Taurodontism and learning disabilities in patients with Klinefelter syndrome. ( 16435639 )
2005
43
DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism. ( 15666299 )
2005
44
Endodontic management of taurodontic teeth. ( 16761713 )
2005
45
Taurodontism in deciduous Molars - A Case Report. ( 15855716 )
2004
46
Taurodontism in six molars: a case report. ( 15273645 )
2004
47
Taurodontism: an endodontic challenge. Report of a case. ( 12775010 )
2003
48
Clinical and radiographic features of a family with autosomal dominant amelogenesis imperfecta with taurodontism. ( 11936459 )
2002
49
A review of taurodontism with new data on indigenous southern African populations. ( 11543709 )
2001
50
Clinical images in oral medicine and maxillofacial radiology. Taurodontism. ( 12066668 )
2001

Variations for Taurodontism

Expression for Taurodontism

Search GEO for disease gene expression data for Taurodontism.

Pathways for Taurodontism

GO Terms for Taurodontism

Biological processes related to Taurodontism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.13 DLX3 DSPP EDA
2 odontogenesis of dentin-containing tooth GO:0042475 8.62 DLX3 EDA

Sources for Taurodontism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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