MCID: TRD003
MIFTS: 31

Taurodontism

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Taurodontism

MalaCards integrated aliases for Taurodontism:

Name: Taurodontism 58 77 54 60 30 56 74
Large Pulp Chambers in the Molars 54
Bull Teeth 54

Characteristics:

OMIM:

58
Inheritance:
? autosomal recessive
likely polygenic


HPO:

33
taurodontism:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 60  
Rare odontological diseases


External Ids:

OMIM 58 272700
MESH via Orphanet 46 C536946
ICD10 via Orphanet 35 K00.2
UMLS via Orphanet 75 C0266039
Orphanet 60 ORPHA3289
MedGen 43 C0266039
SNOMED-CT via HPO 70 258211005 51744007
UMLS 74 C0266039

Summaries for Taurodontism

NIH Rare Diseases : 54 Taurodontism is a disorder of tooth development and occurs most commonly in permanent molar teeth. It refers to an elongation of the pulp chamber of the tooth, which can cause the tooth to lie deep in the jaw (aveolar process). At this time the cause of taurodontism is unknown.

MalaCards based summary : Taurodontism, also known as large pulp chambers in the molars, is related to tooth agenesis and taurodontism, microdontia, and dens invaginatus. An important gene associated with Taurodontism is DLX3 (Distal-Less Homeobox 3). Related phenotypes are abnormality of dental enamel and taurodontia

Wikipedia : 77 Taurodontism is a condition found in the molar teeth of humans whereby the body of the tooth and pulp... more...

Description from OMIM: 272700

Related Diseases for Taurodontism

Graphical network of the top 20 diseases related to Taurodontism:



Diseases related to Taurodontism

Symptoms & Phenotypes for Taurodontism

Human phenotypes related to Taurodontism:

60 33
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of dental enamel 60 33 occasional (7.5%) Occasional (29-5%) HP:0000682
2 taurodontia 60 33 occasional (7.5%) Occasional (29-5%) HP:0000679

Symptoms via clinical synopsis from OMIM:

58
Teeth:
taurodontism
large dental pulp chambers
root deep in alveolar bone

Clinical features from OMIM:

272700

GenomeRNAi Phenotypes related to Taurodontism according to GeneCards Suite gene sharing:

27 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.56 DLX3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.56 DLX3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.56 EDA
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.56 DLX3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.56 DLX3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.56 EDA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.56 DLX3 EDA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.36 EDA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.36 DLX3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.36 DLX3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.36 DLX3 EDA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.36 EDA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.36 DLX3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.36 DLX3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.36 EDA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.36 EDA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.36 DLX3

Drugs & Therapeutics for Taurodontism

Search Clinical Trials , NIH Clinical Center for Taurodontism

Genetic Tests for Taurodontism

Genetic tests related to Taurodontism:

# Genetic test Affiliating Genes
1 Taurodontism 30

Anatomical Context for Taurodontism

Publications for Taurodontism

Articles related to Taurodontism:

(show top 50) (show all 130)
# Title Authors Year
1
Taurodontism. ( 30980345 )
2019
2
Extending Coronectomy Indications to Third Molars with Taurodontism to Prevent Paresthesia and Mandible Fracture. ( 29808127 )
2018
3
Taurodontism and its forensic value: a case report. ( 30712030 )
2018
4
Enamel Pit Defects and Taurodontism in a Patient with Ring Chromosome 14 and 47,XXX. ( 28387189 )
2017
5
A Rare Condition of Bimaxillary Primary Molar Taurodontism. ( 28620641 )
2017
6
Endodontic management of taurodontism with a complex root canal anatomy in mandibular posterior teeth. ( 29269370 )
2017
7
Taurodontism, Root Dilaceration, and Tooth Transposition: A Radiographic Study of a Population With Nonsyndromic Cleft Lip and/or Palate. ( 26247709 )
2016
8
Taurodontism in patients with nonsyndromic cleft lip and palate in a Brazilian population: a case control evaluation with panoramic radiographs. ( 26428895 )
2015
9
Exploring the biomechanics of taurodontism. ( 25407030 )
2015
10
Taurodontism, variations in tooth number, and misshapened crowns in Wnt10a null mice and human kindreds. ( 25629078 )
2015
11
Interradicular dentin dysplasia associated with amelogenesis imperfecta with taurodontism or trichodentoosseous syndrome: a diagnostic dilemma. ( 24992867 )
2014
12
Assessing the association of taurodontism with numeric dentition anomalies in an adult central Indian population. ( 25097429 )
2014
13
Taurodontism. ( 25210354 )
2014
14
Non syndromic familial bilateral decidious taurodontism - a first case report. ( 25654041 )
2014
15
Bilateral taurodontism in primary dentition with hypodontia. ( 23345504 )
2013
16
Managing a mandibular second premolar with three-canal and taurodontism: a case report. ( 23411506 )
2013
17
Prevalence of taurodontism and its association with various oral conditions in an Indian population. ( 23534039 )
2013
18
Taurodontism. ( 23598931 )
2013
19
Taurodontism: A minor diagnostic criterion in Laurence-Moon/Bardet-Biedl syndromes. ( 23638763 )
2013
20
Taurodontism in deciduous molars. ( 23737594 )
2013
21
Taurodontism in a central anatolian population. ( 23946746 )
2013
22
Endodontic treatment of hypertaurodontism with multiple bilateral taurodontism. ( 24082583 )
2013
23
Biometric Analysis - A Reliable Indicator for Diagnosing Taurodontism using Panoramic Radiographs. ( 24086912 )
2013
24
Prevalence of taurodontism in the North Indian population. ( 24455077 )
2013
25
Taurodontism: A dental rarity. ( 24574680 )
2013
26
Taurodontism in Brazilian patients with tooth agenesis and first and second-degree relatives: a case-control study. ( 22647425 )
2012
27
Prevalence of taurodontism in premolars and molars in the South of iran. ( 22991630 )
2012
28
Prevalence of taurodontism in primary mandibular first molars of ethnic Indian children. ( 23032243 )
2012
29
Oligodontia with taurodontism in monozygous twins. ( 23272313 )
2012
30
Side of dental anomalies and taurodontism as potential clinical markers for cleft subphenotypes. ( 20507240 )
2011
31
Quantification of taurodontism: interests in the early diagnosis of hypohidrotic ectodermal dysplasia. ( 20374512 )
2010
32
Taurodontism in children with hypodontia and supernumerary teeth: a case control study. ( 20483017 )
2010
33
Multiple bilateral taurodontism. A case report. ( 20951311 )
2010
34
Multiple taurodontism: the challenge of endodontic treatment. ( 21206170 )
2010
35
Taurodontism--a review. ( 19518034 )
2009
36
"Taurodontism" an endodontic challenge: a case report. ( 19776518 )
2009
37
Taurodontism and Van der Woude syndrome. Is there an association? ( 18298211 )
2008
38
Taurodontism: a review of the condition and endodontic treatment challenges. ( 18363703 )
2008
39
Assessing the proposed association between tooth agenesis and taurodontism in 975 paediatric subjects. ( 18384350 )
2008
40
Severely hypoplastic amelogenesis imperfecta with taurodontism. ( 17559453 )
2007
41
Prevalence of taurodontism in premolars among patients at a tertiary care institution in Trinidad. ( 18198744 )
2007
42
Taurodontism of deciduous and permanent molars: report of two cases. ( 16582531 )
2006
43
Endodontic treatment of a taurodontism tooth: report of a case. ( 24454455 )
2006
44
DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism. ( 15666299 )
2005
45
Taurodontism and learning disabilities in patients with Klinefelter syndrome. ( 16435639 )
2005
46
Taurodontism in six molars: a case report. ( 15273645 )
2004
47
Taurodontism in deciduous Molars - A Case Report. ( 15855716 )
2004
48
Taurodontism: an endodontic challenge. Report of a case. ( 12775010 )
2003
49
Clinical and radiographic features of a family with autosomal dominant amelogenesis imperfecta with taurodontism. ( 11936459 )
2002
50
A review of taurodontism with new data on indigenous southern African populations. ( 11543709 )
2001

Variations for Taurodontism

Expression for Taurodontism

Search GEO for disease gene expression data for Taurodontism.

Pathways for Taurodontism

GO Terms for Taurodontism

Biological processes related to Taurodontism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.33 DLX3 DSPP EDA
2 odontogenesis of dentin-containing tooth GO:0042475 8.96 DLX3 EDA
3 odontoblast differentiation GO:0071895 8.62 DLX3 DSPP

Sources for Taurodontism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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