MCID: TRD003
MIFTS: 30

Taurodontism

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Taurodontism

MalaCards integrated aliases for Taurodontism:

Name: Taurodontism 57 74 20 29 54 71
Large Pulp Chambers in the Molars 20
Bull Teeth 20

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
? autosomal recessive
likely polygenic


HPO:

31
taurodontism:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM® 57 272700
MedGen 41 C0266039
SNOMED-CT via HPO 68 258211005 51744007
UMLS 71 C0266039

Summaries for Taurodontism

GARD : 20 Taurodontism is a disorder of tooth development and occurs most commonly in permanent molar teeth. It refers to an elongation of the pulp chamber of the tooth, which can cause the tooth to lie deep in the jaw (aveolar process). At this time the cause of taurodontism is unknown.

MalaCards based summary : Taurodontism, also known as large pulp chambers in the molars, is related to trichodentoosseous syndrome and amelogenesis imperfecta. An important gene associated with Taurodontism is DLX3 (Distal-Less Homeobox 3). Affiliated tissues include bone and heart, and related phenotypes are taurodontia and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Taurodontism is a condition found in the molar teeth of humans whereby the body of the tooth and pulp... more...

More information from OMIM: 272700

Related Diseases for Taurodontism

Diseases related to Taurodontism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 trichodentoosseous syndrome 31.7 DSPP DLX3
2 amelogenesis imperfecta 30.9 DSPP DLX3
3 tooth agenesis 29.5 EDA DSPP DLX3
4 amelogenesis imperfecta, type iv 11.5
5 taurodontism, microdontia, and dens invaginatus 11.2
6 ackerman syndrome 10.9
7 cranioectodermal dysplasia 10.9
8 48,xxxy syndrome 10.9
9 pyramidal molars-abnormal upper lip syndrome 10.9
10 hypogonadotropic hypogonadism 10.2
11 cleft palate, isolated 10.2
12 hair whorl 10.1
13 teeth, supernumerary 10.1
14 cleft lip 10.1
15 47,xyy 10.1
16 down syndrome 10.0
17 cleft lip/palate 10.0
18 van der woude syndrome 1 10.0
19 dentin dysplasia 10.0
20 48,xyyy 10.0
21 chromosomal triplication 10.0
22 dwarfism 10.0
23 hypoplastic amelogenesis imperfecta 10.0
24 dental abscess 9.8 DSPP DLX3
25 ameloonychohypohidrotic syndrome 9.8
26 ear malformation 9.8
27 clouston syndrome 9.8
28 hemifacial microsomia 9.8
29 osteoporosis 9.8
30 smith-magenis syndrome 9.8
31 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 9.8
32 periodontitis, chronic 9.8
33 teeth, congenital absence of, with taurodontia and sparse hair 9.8
34 focal dermal hypoplasia 9.8
35 tooth size 9.8
36 polydactyly 9.8
37 hurler syndrome 9.8
38 bone mineral density quantitative trait locus 8 9.8
39 bone mineral density quantitative trait locus 15 9.8
40 ring chromosome 14 syndrome 9.8
41 pulpitis 9.8
42 dental fluorosis 9.8
43 ectodermal dysplasia 9.8
44 palmoplantar keratosis 9.8
45 periodontitis 9.8
46 learning disability 9.8
47 triple x syndrome 9.8
48 48, xxxx 9.8
49 amelogenesis imperfecta hypomaturation type 9.8
50 craniofacial microsomia 9.8

Graphical network of the top 20 diseases related to Taurodontism:



Diseases related to Taurodontism

Symptoms & Phenotypes for Taurodontism

Human phenotypes related to Taurodontism:

31
# Description HPO Frequency HPO Source Accession
1 taurodontia 31 HP:0000679

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Teeth:
taurodontism
large dental pulp chambers
root deep in alveolar bone

Clinical features from OMIM®:

272700 (Updated 05-Mar-2021)

GenomeRNAi Phenotypes related to Taurodontism according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.5 EDA
2 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.5 DLX3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-141 9.5 DLX3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-144 9.5 EDA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.5 DLX3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.5 DLX3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.5 DLX3 EDA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.5 EDA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-216 9.5 DLX3 EDA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.5 EDA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.5 EDA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.5 EDA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.5 DLX3
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.26 DLX3
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.26 DLX3
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-4 9.26 DLX3
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.26 DLX3

Drugs & Therapeutics for Taurodontism

Search Clinical Trials , NIH Clinical Center for Taurodontism

Genetic Tests for Taurodontism

Genetic tests related to Taurodontism:

# Genetic test Affiliating Genes
1 Taurodontism 29

Anatomical Context for Taurodontism

MalaCards organs/tissues related to Taurodontism:

40
Bone, Heart

Publications for Taurodontism

Articles related to Taurodontism:

(show top 50) (show all 361)
# Title Authors PMID Year
1
The conditions manifesting taurodontism. 61 57
7091187 1982
2
Taurodontism, an isolated trait associated with syndromes and X-chromosomal aneuploidy. 57 61
6992564 1980
3
Taurodontism: familial tendencies demonstrated in eleven of fourteen case reports. 57 61
4514516 1973
4
Taurodontism and concomitant hypodontia in siblings. 61 57
4502158 1972
5
Malformation syndromes. A selected miscellany. 57
819054 1975
6
Taurodont Teeth in South African Races. 57
17104204 1928
7
DLX3 mutation in a new family and its phenotypic variations. 61 54
18362318 2008
8
Cranial suture biology and dental development: genetic and clinical perspectives. 61 54
17686002 2007
9
Enamel, dentine and pulp in talon primary maxillary central incisors: a histomorphometric study. 61 54
17908537 2007
10
Developmental biology and genetics of dental malformations. 61 54
17552940 2007
11
Dental Age, Agenesis, and Morphology in Patients With Operated Single-Suture Craniosynostoses. 61
32815397 2021
12
Association between Dental Anomalies and Orofacial Clefts: A Meta-analysis. 61
33030085 2020
13
Oral rehabilitation in a patient with Jeune syndrome presenting with multiple teeth agenesis. 61
32620036 2020
14
Taurodontism and C-shaped anatomy: is there an association? 61
32803678 2020
15
Is there any relationship between hypodontia and hyperdontia with taurodontism, microdontia and macrodontia? A retrospective study. 61
32525115 2020
16
Clouston syndrome with pili canaliculi, pili torti, overgrown hyponychium, onycholysis, taurodontism and absence of palmoplantar keratoderma. 61
32220018 2020
17
Taurodontism in the first permanent molars in Van der Woude syndrome compared to isolated cleft palate. 61
32558917 2020
18
LEF1 haploinsufficiency causes ectodermal dysplasia. 61
32022899 2020
19
Correction to: Taurodontism. 61
31154584 2020
20
Taurodontism. 61
30980345 2020
21
Epithelial Wnt10a Is Essential for Tooth Root Furcation Morphogenesis. 61
31914354 2020
22
Application of cone-beam computed tomography in the analysis and management of intricate internal anatomy of hyper- and mesotaurodontic teeth. 61
33384498 2020
23
Prevalence and Characteristics of Three-rooted Mandibular Molars in Saudi Population: A Retrospective Radiographic Analysis. 61
32381827 2020
24
The Neanderthal teeth from Marillac (Charente, Southwestern France): Morphology, comparisons and paleobiology. 61
31765984 2020
25
In situ observations on the dentition and oral cavity of the Neanderthal skeleton from Altamura (Italy). 61
33264306 2020
26
Endodontic treatment of a hypertaurodontic mandibular left second molar in a patient with many taurodonts combined with multiple pulp stones. 61
30113740 2019
27
Trichodentoosseous syndrome: a case report and review of literature. 61
31938567 2019
28
Systematic review of oral and craniofacial findings in patients with Fabry disease or Pompe disease. 61
31405600 2019
29
Oculo-auriculo-vertebral spectrum with radial defects, a bifid condyle and taurodontism: A case report. 61
31689014 2019
30
Dental abnormalities in individuals with pathogenic germline variation in DICER1. 61
31313479 2019
31
Oral Rehabilitation of a Child with Hypohidrotic Ectodermal Dysplasia. 61
31645258 2019
32
A long-term clinical study on individuals with amelogenesis imperfecta. 61
31417061 2019
33
Klinefelter's syndrome and taurodontism. 61
31266283 2019
34
Relationship between obesity and prevalence of dental anomalies: Does body mass index play a role? 61
31246082 2019
35
Tooth defects of EEC and AEC syndrome caused by heterozygous TP63 mutations in three Chinese families and genotype-phenotype correlation analyses of TP63-related disorders. 61
31050217 2019
36
Endodontic Management of Various Canal Morphologies in Maxillary First Molars: A Series of Four Case Reports. 61
31858089 2019
37
SATB2-associated syndrome (SAS) and associated dental findings. 61
30648748 2019
38
Oral manifestations in patients and dogs with mucopolysaccharidosis Type VII. 61
30653816 2019
39
Bilateral taurodontism in permanent maxillary first molar. 61
31169169 2019
40
Oral manifestations of ellis-van creveld syndrome. A rare case report. 61
31001402 2019
41
Determination of mandibular morphology in a TURKISH population with Down syndrome using panoramic radiography. 61
30808330 2019
42
Oro-dental phenotype in patients with RUNX2 duplication. 61
29852250 2019
43
Novel dental phenotype in non-syndromic Pierre Robin Sequence: A retrospective study. 61
30391793 2019
44
Novel DLX3 variants in amelogenesis imperfecta with attenuated tricho-dento-osseous syndrome. 61
30095208 2019
45
Oral Manifestations of Nance-Horan Syndrome: A Report of a Rare Case. 61
32015664 2019
46
Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus. 61
31616463 2019
47
Genetic Risk of Talon Cusp: Talon Cusp in Five Siblings. 61
31534801 2019
48
Dental developmental alterations in patients with dilacerated teeth. 61
30573716 2019
49
Taurodontism and its forensic value: a case report. 61
30712030 2018
50
Dental radiographic findings in 18 individuals with SATB2-associated syndrome. 61
30315422 2018

Variations for Taurodontism

Expression for Taurodontism

Search GEO for disease gene expression data for Taurodontism.

Pathways for Taurodontism

GO Terms for Taurodontism

Biological processes related to Taurodontism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.33 EDA DSPP DLX3
2 odontogenesis of dentin-containing tooth GO:0042475 8.96 EDA DLX3
3 odontoblast differentiation GO:0071895 8.62 DSPP DLX3

Sources for Taurodontism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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