MCID: TYL001
MIFTS: 31

Taylor's Syndrome

Categories: Reproductive diseases

Aliases & Classifications for Taylor's Syndrome

MalaCards integrated aliases for Taylor's Syndrome:

Name: Taylor's Syndrome 12 15
Pelvic Congestion Syndrome 12 73
Congestion-Fibrosis Syndrome 12
Taylor Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9346
ICD9CM 35 625.5
SNOMED-CT 68 39402007
UMLS 73 C0152078

Summaries for Taylor's Syndrome

MalaCards based summary : Taylor's Syndrome, also known as pelvic congestion syndrome, is related to interstitial cystitis and varicose veins, and has symptoms including pain and other symptoms associated with female genital organs, mittelschmerz and unspecified symptom associated with female genital organs. An important gene associated with Taylor's Syndrome is CNTN3 (Contactin 3), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Acetylcholine and Acetaminophen have been mentioned in the context of this disorder. Related phenotypes are embryo and nervous system

Related Diseases for Taylor's Syndrome

Diseases related to Taylor's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 interstitial cystitis 11.3
2 varicose veins 10.1
3 body mass index quantitative trait locus 1 10.0
4 varicocele 10.0
5 immunodeficiency-centromeric instability-facial anomalies syndrome 10.0 DNMT1 DNMT3L
6 vein disease 9.9 BLOC1S2 F2
7 osteoarthritis 9.9
8 may-thurner syndrome 9.9
9 persistent genital arousal disorder 9.9
10 diabetes mellitus, transient neonatal, 1 9.9 DNMT3L KCNJ11
11 parametritis 9.8 F2 LY86

Graphical network of the top 20 diseases related to Taylor's Syndrome:



Diseases related to Taylor's Syndrome

Symptoms & Phenotypes for Taylor's Syndrome

UMLS symptoms related to Taylor's Syndrome:


pain and other symptoms associated with female genital organs, mittelschmerz, unspecified symptom associated with female genital organs, other specified symptoms associated with female genital organs, female genital pain and other symptoms

MGI Mouse Phenotypes related to Taylor's Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.35 BLOC1S2 DNMT1 DNMT3L F2 RASA1
2 nervous system MP:0003631 9.17 BLOC1S2 DNMT1 DNMT3L F2 GNRH1 KCNJ11

Drugs & Therapeutics for Taylor's Syndrome

Drugs for Taylor's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Cycloserine Approved Phase 4 68-41-7 6234 401
4
Saw palmetto Approved, Experimental, Investigational Phase 4
5
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
6
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
7 Prulifloxacin Investigational Phase 4 123447-62-1
8 onabotulinumtoxinA Phase 4,Phase 3,Phase 2,Phase 1
9 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Botulinum Toxins Phase 4,Phase 3,Phase 2,Phase 1
12 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 2,Phase 1
13 Acetylcholine Release Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
14 abobotulinumtoxinA Phase 4,Phase 3,Phase 2,Phase 1
15 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
16 Neuromuscular Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Anti-Infective Agents Phase 4,Phase 2
18 Anti-Infective Agents, Urinary Phase 4
19 Antitubercular Agents Phase 4
20 Anti-Bacterial Agents Phase 4,Phase 2
21 Renal Agents Phase 4
22 Antimetabolites Phase 4
23 Antibiotics, Antitubercular Phase 4
24 Topoisomerase Inhibitors Phase 4
25 Acidophilus Phase 4
26 Nucleic Acid Synthesis Inhibitors Phase 4
27 Saw palmetto extract Phase 4
28 Fluoroquinolones Phase 4
29 Sildenafil Citrate Phase 4 171599-83-0
30 Phosphodiesterase Inhibitors Phase 4
31 Vasodilator Agents Phase 4
32 Citrate Phase 4
33 Phosphodiesterase 5 Inhibitors Phase 4
34 Antiparasitic Agents Phase 4
35 Antiprotozoal Agents Phase 4
36 Laxatives Phase 4
37 Carboxymethylcellulose Sodium Phase 4
38 Cathartics Phase 4
39 Antimalarials Phase 4
40 Gastrointestinal Agents Phase 4
41
Pregabalin Approved, Illicit, Investigational Phase 3 148553-50-8 5486971
42
Tamsulosin Approved, Investigational Phase 3,Not Applicable 106133-20-4 129211
43
Alfuzosin Approved, Investigational Phase 3 81403-80-7 2092
44
Dutasteride Approved, Investigational Phase 3 164656-23-9 6918296 152945
45
Glutamic Acid Approved, Nutraceutical Phase 3 56-86-0 33032
46 Analgesics Phase 3,Phase 2
47 Central Nervous System Depressants Phase 3,Phase 2
48 Psychotropic Drugs Phase 3
49 Anti-Anxiety Agents Phase 3
50 Anticonvulsants Phase 3

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4 D-Cycloserine;Placebo (for D-cycloserine)
2 Treatment of Chronic Bacterial Prostatitis Completed NCT02130713 Phase 4 Third generation fluoroquinolone
3 Effectiveness of Sympathetic Plexus Block on Male Pelvic Pain (Prostatitis, Prostatodynia) Suspended NCT00194636 Phase 4
4 Botox as a Treatment for Chronic Male Pelvic Pain Syndrome Terminated NCT00194623 Phase 4 Botulinum Toxin A (Botox)
5 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
6 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4 doxycycline;placebo
7 Efficacy & Safety Study of Pregabalin to Treat Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Unknown status NCT00371033 Phase 3 Pregabalin;Placebo
8 Efficacy Study of a Standardized Pollen Extract Preparation (Cernilton) to Treat Inflammatory Chronic Prostatitis-Chronic Pelvic Pain Syndrome (CP-CPPS) Completed NCT00919893 Phase 3 Cernilton;Placebo
9 Trial to Compare Alfuzosin Versus Placebo in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Completed NCT00103402 Phase 3 Alfuzosin
10 Efficacy Study of Acupuncture to Relieve Symptoms of Chronic Prostatitis Completed NCT00260637 Phase 2, Phase 3
11 Effects of Proxelan Somministration in Patients With Chronic Prostatitis Recruiting NCT03629769 Phase 3 Proxelan
12 Electromyographic Study for the Help and Guidance of BoNTA Administration in the Treatment of Chronic Pelvic Floor Pain Not yet recruiting NCT03715777 Phase 3 Clostridium botulinum type A (BoNTA)
13 Botulinum Toxin Type A for the Treatment of Male Chronic Pelvic Pain Syndrome Terminated NCT00464373 Phase 3 Botulinum Toxin Type A;Placebo
14 JALYN for Benign Prostatic Hyperplasia (BPH) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Terminated NCT01830829 Phase 3 Jalyn;Placebo
15 Laparoscopic Prostatectomy for Chronic Prostatitis Unknown status NCT00775515 Phase 2
16 Use of Silodosin to Treat Moderate to Severe Abacterial Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Completed NCT00740779 Phase 2 Silodosin 8 mg;Placebo;Silodosin 4 mg
17 An Open-Label Study of CC-10004 for Chronic Prostatitis/Chronic Pelvic Pain Syndrome Completed NCT00701311 Phase 2 CC-10004
18 Botox for Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Completed NCT00529386 Phase 2 Botox;Lidocaine
19 A Clinical Study to Investigate the Efficacy, Safety and Pharmacokinetics of ASP3652 in Patients With Chronic Abacterial Prostatitis / Chronic Pelvic Pain Syndrome (CP/CPPS) Completed NCT01391338 Phase 2 ASP3652;Placebo
20 An Efficacy And Safety Study Of Tanezumab For The Treatment Of Pain Associated With Chronic Abacterial Prostatitis Completed NCT00826514 Phase 2 Tanezumab;Placebo
21 Efficacy and Safety of AQX-1125 in Subjects With Chronic Prostatitis/Chronic Pelvic Pain Syndrome Terminated NCT03500159 Phase 2 AQX-1125 200 mg;Placebo
22 Open-Label Study of Thalidomide for Chronic Prostatitis/Chronic Pelvic Pain Terminated NCT00301405 Phase 2 Thalidomide
23 Injection With OnabotulinumtoxinA (Botox) for the Treatment of Chronic Pelvic Pain Unknown status NCT02173405 Phase 1 OnabotulinumtoxinA;Placebo
24 Efficacy of Extracorporal Shock Wave Therapy in Patient With Chronic Non-bacterial Prostatitis / Chronic Pelvic Pain Syndrome Unknown status NCT01714830 Not Applicable
25 Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromE Unknown status NCT02033863
26 Shocking Therapy for Chronic Pelvic Pain Syndrome Unknown status NCT01828996 Not Applicable
27 Efficacy of Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndromes Unknown status NCT02588274 Not Applicable
28 Efficacy Study of Tamsulosin and Tolterodine Treatment for Chronic Prostatitis Unknown status NCT00913315 Not Applicable tolterodine;tamsulosin;placebo
29 Pelvic Embolisation to Reduce Recurrent Varicose Veins - Recurrent Unknown status NCT01909024 Not Applicable
30 Fibered Platinum Coils vs Vascular Plugs in Pelvic Varices Embolization for the Treatment of Pelvic Congestion Syndrome Completed NCT02796092 Not Applicable
31 Sono-Electro-Magnetic Therapy for Refractory Chronic Pelvic Pain Syndrome Completed NCT00710073 Not Applicable
32 Combined Sono-electro-magnetic Therapy for Treatment of Refractory Chronic Pelvic Pain Syndrome Completed NCT00688506 Not Applicable
33 Efficacy of Electromagnetic Stimulation Therapy for Chronic Prostatitis and Chronic Pelvic Pain Syndrome Completed NCT00922012 Not Applicable
34 Clinical Efficacy of Roxithromycin in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome Completed NCT01843946
35 Linkage Analysis in Interstitial Cystitis Completed NCT00675298
36 Physical Therapy Trial for Pelvic Pain Completed NCT00434343 Not Applicable
37 Diagnostic Challenges in IC (and Male CPPS) Completed NCT00672087
38 Observational Study of Control Participants for the MAPP Research Network Completed NCT01098292
39 Changes in Inflammatory and Contractile Protein Expression in Patients With Painful Bladder Syndrome/IC. Completed NCT00775281
40 Brain Effects of Sacral Neuromodulation Completed NCT00610064 Not Applicable
41 Pelvic Girdle Pain in a Pregnant Population in Western Norway. Completed NCT01098136 Not Applicable
42 Chronic Pelvic Pain Study of Individuals With Diagnoses or Symptoms of Interstitial Cystitis and/ or Chronic Prostatitis Completed NCT01098279
43 Histopathological Diagnosis of Adenomyosis Completed NCT02340533 Not Applicable
44 Pelvic Congestion Syndrome and Endometriosis Recruiting NCT03568149
45 Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndrome Recruiting NCT03213938 Not Applicable
46 Embolization of Pelvic Veins in Treatment of Pelvic Congestion Syndrome Recruiting NCT03165214 Not Applicable
47 Quantify the Degree of Pain Relief of Pelvic Congestion Syndrome Following Gonadal Vein Embolization Recruiting NCT03794466
48 Different Modes of Assessment on Acupuncture Effect on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome Recruiting NCT03641807 Not Applicable
49 The Effects of Physiotherapeutic Interventions Applied to the Chronic Pelvic Pain Syndrome Recruiting NCT03755375 Not Applicable
50 Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Recruiting NCT00499317

Search NIH Clinical Center for Taylor's Syndrome

Genetic Tests for Taylor's Syndrome

Anatomical Context for Taylor's Syndrome

Publications for Taylor's Syndrome

Articles related to Taylor's Syndrome:

(show top 50) (show all 105)
# Title Authors Year
1
Pelvic congestion syndrome due to agenesis of the infrarenal inferior vena cava. ( 30305863 )
2019
2
Regarding "Correlation between pelvic congestion syndrome and body mass index". ( 30554744 )
2019
3
Sensitivity and specificity of clinical findings for the diagnosis of pelvic congestion syndrome in women with chronic pelvic pain. ( 28379058 )
2018
4
Compression treatment of pelvic congestion syndrome. ( 28639874 )
2018
5
Correlation between pelvic congestion syndrome and body mass index. ( 28943005 )
2018
6
A Randomized Trial of Endovascular Embolization Treatment in Pelvic Congestion Syndrome: Fibered Platinum Coils versus Vascular Plugs with 1-Year Clinical Outcomes. ( 29174618 )
2018
7
Noninvasive diagnostic tools for pelvic congestion syndrome: a systematic review. ( 29381188 )
2018
8
Left Ovarian Vein Drainage Variant: An Exceptional Cause of Pelvic Congestion Syndrome. ( 29398307 )
2018
9
Pelvic Congestion Syndrome: Systematic Review of Treatment Success. ( 29628614 )
2018
10
A Case of Reverse Pelvic Congestion Syndrome? ( 30368316 )
2018
11
A standardized ultrasound approach to pelvic congestion syndrome. ( 27799418 )
2017
12
Conservative treatment of pelvic congestion syndrome: indications and opportunities. ( 28277860 )
2017
13
Pelvic congestion syndrome initially misdiagnosed as a hydrosalpinx - a diagnostic challenge. ( 28397208 )
2017
14
Inferior Vena Cava Agenesis: A Rare Cause of Pelvic Congestion Syndrome. ( 28511477 )
2017
15
Objective measurements of pelvic venous reflux and stratification of severity of venous reflux in pelvic congestion syndrome due to pelvic venous reflux. ( 28521534 )
2017
16
Embolization of ovarian vein for pelvic congestion syndrome with ethylene vinyl alcohol copolymer (Onyx®). ( 28647478 )
2017
17
Diagnosis and treatment of pelvic congestion syndrome: Single-centre experiences. ( 28791845 )
2017
18
Evaluation of embolization for periuterine varices involving chronic pelvic pain secondary to pelvic congestion syndrome. ( 28076514 )
2016
19
Pelvic congestion syndrome: the current state of the literature. ( 26404449 )
2016
20
Evaluation of Effectiveness of Embolization in Pelvic Congestion Syndrome with the New Vascular Occlusion Device (ArtVentive EOS™): Preliminary Results. ( 27250353 )
2016
21
Efficacy of endovascular treatment for pelvic congestion syndrome. ( 27318059 )
2016
22
Pelvic congestion syndrome and left renal compression syndrome - clinical features and therapeutic approaches. ( 27428495 )
2016
23
Pelvic congestion syndrome masquerading as osteoarthritis of the hip. ( 27994874 )
2016
24
Left ovarian vein dilation or pelvic congestion syndrome secondary to abdominal aortic dissection: incidental findings on CT angiography. ( 25542755 )
2015
25
Clinical outcome after treatment of pelvic congestion syndrome: sense and nonsense. ( 25729071 )
2015
26
Evaluation of effectiveness of endovascular embolisation for the treatment of pelvic congestion syndrome--preliminary study. ( 26117971 )
2015
27
Venous angioplasty and stenting improve pelvic congestion syndrome caused by venous outflow obstruction. ( 26992307 )
2015
28
Hypersensitivity to nickel in a patient treated with coil embolization for pelvic congestion syndrome. ( 26992312 )
2015
29
Diagnosis and treatment of the pelvic congestion syndrome. ( 26993690 )
2015
30
Nonthrombotic Venous Obstructions Cause Pelvic Congestion Syndrome. ( 26993693 )
2015
31
Pelvic Congestion Syndrome. ( 27678858 )
2015
32
Robotic Single-Incision Ovarian Vein Ligation for Pelvic Congestion Syndrome. ( 27678874 )
2015
33
Evaluation of the efficacy of endovascular treatment of pelvic congestion syndrome. ( 24183954 )
2014
34
Safety, efficacy, and prognostic factors in endovascular treatment of pelvic congestion syndrome. ( 24486124 )
2014
35
Case report: pelvic congestion syndrome as an unusual etiology for chronic hip pain in 2 active, middle-age women. ( 24587865 )
2014
36
Pelvic congestion syndrome diagnosed using endoscopic ultrasonography. ( 24618909 )
2014
37
Pelvic congestion syndrome: etiology of pain, diagnosis, and clinical management. ( 24745902 )
2014
38
Pelvic congestion syndrome and pelvic varicosities. ( 24840963 )
2014
39
Nutcracker Syndrome Accompanying Pelvic Congestion Syndrome; Color Doppler Sonography and Multislice CT Findings: A Case Report. ( 25035694 )
2014
40
Secondary pelvic congestion syndrome: description and radiographic diagnosis. ( 25171280 )
2014
41
Role of trans vaginal ultrasound and Doppler in diagnosis of pelvic congestion syndrome. ( 25177607 )
2014
42
The role of duplex ultrasound in the workup of pelvic congestion syndrome. ( 26992966 )
2014
43
Endovascular intervention for pelvic congestion syndrome is justified for chronic pelvic pain relief and patient satisfaction. ( 26993385 )
2014
44
Embolization of incompetent pelvic veins for the treatment of recurrent varicose veins in lower limbs and pelvic congestion syndrome. ( 22547030 )
2013
45
Endovascular treatment of pelvic congestion syndrome: visual analog scale (VAS) long-term follow-up clinical evaluation in 202 patients. ( 23456353 )
2013
46
Chronic hip pain as a presenting symptom in pelvic congestion syndrome. ( 23622048 )
2013
47
Pelvic congestion syndrome. ( 23795992 )
2013
48
Pelvic congestion syndrome. ( 24436564 )
2013
49
Pelvic Congestion Syndrome Initially Detected by Contrast-Enhanced F-18 FDG-PET/CT. ( 24895512 )
2013
50
The Role of Duplex Ultrasound in the Pelvic Congestion Syndrome Workup. ( 26993924 )
2013

Variations for Taylor's Syndrome

Expression for Taylor's Syndrome

Search GEO for disease gene expression data for Taylor's Syndrome.

Pathways for Taylor's Syndrome

Pathways related to Taylor's Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 F2 KCNJ11

GO Terms for Taylor's Syndrome

Biological processes related to Taylor's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.33 DNMT1 F2 GNRH1
2 response to testosterone GO:0033574 9.26 GNRH1 KCNJ11
3 DNA methylation GO:0006306 8.96 DNMT1 DNMT3L
4 DNA methylation on cytosine GO:0032776 8.62 DNMT1 DNMT3L

Molecular functions related to Taylor's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme activator activity GO:0008047 8.62 DNMT3L F2

Sources for Taylor's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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