Aliases & Classifications for Taylor's Syndrome

MalaCards integrated aliases for Taylor's Syndrome:

Name: Taylor's Syndrome 12 15
Pelvic Congestion Syndrome 12 73
Congestion-Fibrosis Syndrome 12
Taylor Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9346
ICD9CM 35 625.5
SNOMED-CT 68 156027002 39402007
UMLS 73 C0152078

Summaries for Taylor's Syndrome

MalaCards based summary : Taylor's Syndrome, also known as pelvic congestion syndrome, is related to interstitial cystitis and chronic inflammation of lacrimal passage, and has symptoms including unspecified symptom associated with female genital organs, mittelschmerz and pain and other symptoms associated with female genital organs. An important gene associated with Taylor's Syndrome is CNTN3 (Contactin 3), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Acetylcholine and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include prostate and brain, and related phenotypes are cardiovascular system and nervous system

Related Diseases for Taylor's Syndrome

Diseases related to Taylor's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 interstitial cystitis 11.1
2 chronic inflammation of lacrimal passage 10.0 FLNA KCNJ11
3 urethral calculus 10.0 F2 FLNA
4 leech infestation 10.0 F2 FLNA
5 immunodeficiency-centromeric instability-facial anomalies syndrome 10.0 DNMT1 DNMT3L
6 diabetes mellitus, transient neonatal, 1 9.9 DNMT3L KCNJ11
7 lower urinary tract calculus 9.9 F2 FLNA
8 varicose veins 9.7
9 varicocele 9.7
10 vein disease 9.7 BLOC1S2 F2
11 parametritis 9.5 F2 LY86
12 migraine with aura 9.4 F2 FLNA

Graphical network of the top 20 diseases related to Taylor's Syndrome:



Diseases related to Taylor's Syndrome

Symptoms & Phenotypes for Taylor's Syndrome

UMLS symptoms related to Taylor's Syndrome:


unspecified symptom associated with female genital organs, mittelschmerz, pain and other symptoms associated with female genital organs, other specified symptoms associated with female genital organs, female genital pain and other symptoms

MGI Mouse Phenotypes related to Taylor's Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 RASA1 BLOC1S2 DNMT3L F2 FLNA KCNJ11
2 nervous system MP:0003631 9.56 RASA1 BLOC1S2 DNMT1 DNMT3L F2 FLNA
3 digestive/alimentary MP:0005381 9.55 RASA1 DNMT1 F2 FLNA GNRH1
4 reproductive system MP:0005389 9.1 OVGP1 DNMT1 DNMT3L F2 FLNA GNRH1

Drugs & Therapeutics for Taylor's Syndrome

Drugs for Taylor's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Cycloserine Approved Phase 4 68-41-7 401 6234
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
6 Prulifloxacin Investigational Phase 4 123447-62-1
7 abobotulinumtoxinA Phase 4,Phase 3,Phase 2,Phase 1
8 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Neuromuscular Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
11 onabotulinumtoxinA Phase 4,Phase 3,Phase 2,Phase 1
12 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 2,Phase 1
14 Botulinum Toxins Phase 4,Phase 3,Phase 2,Phase 1
15 Permixon Phase 4
16 Renal Agents Phase 4
17 Fluoroquinolones Phase 4
18 Topoisomerase Inhibitors Phase 4
19 Nucleic Acid Synthesis Inhibitors Phase 4
20 Anti-Bacterial Agents Phase 4,Phase 2
21 Antibiotics, Antitubercular Phase 4
22 Anti-Infective Agents Phase 4,Phase 2
23 Antitubercular Agents Phase 4
24 Antimetabolites Phase 4
25 Sildenafil Citrate Phase 4 171599-83-0
26 Cathartics Phase 4
27 Gastrointestinal Agents Phase 4
28 Vasodilator Agents Phase 4
29 Phosphodiesterase 5 Inhibitors Phase 4
30 Phosphodiesterase Inhibitors Phase 4
31 Laxatives Phase 4
32 Antiparasitic Agents Phase 4
33 Antiprotozoal Agents Phase 4
34 Antimalarials Phase 4
35 Carboxymethylcellulose Sodium Phase 4
36 Acidophilus Nutraceutical Phase 4
37 Saw Palmetto Nutraceutical Phase 4
38 Citrate Nutraceutical Phase 4
39
Pregabalin Approved, Illicit, Investigational Phase 3 148553-50-8 5486971
40
Tamsulosin Approved, Investigational Phase 3,Not Applicable 106133-20-4 129211
41
Alfuzosin Approved, Investigational Phase 3 81403-80-7 2092
42
Dutasteride Approved, Investigational Phase 3 164656-23-9 152945 6918296
43
Glutamic Acid Approved, Nutraceutical Phase 3 56-86-0 33032
44 Analgesics Phase 3,Phase 2
45 calcium channel blockers Phase 3
46 Central Nervous System Depressants Phase 3,Phase 2
47 Adrenergic Agents Phase 3,Phase 2,Not Applicable
48 Adrenergic alpha-1 Receptor Antagonists Phase 3,Phase 2,Not Applicable
49 Adrenergic alpha-Antagonists Phase 3,Phase 2,Not Applicable
50 Adrenergic Antagonists Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4 D-Cycloserine;Placebo (for D-cycloserine)
2 Treatment of Chronic Bacterial Prostatitis Completed NCT02130713 Phase 4 Third generation fluoroquinolone
3 Effectiveness of Sympathetic Plexus Block on Male Pelvic Pain (Prostatitis, Prostatodynia) Suspended NCT00194636 Phase 4
4 Botox as a Treatment for Chronic Male Pelvic Pain Syndrome Terminated NCT00194623 Phase 4 Botulinum Toxin A (Botox)
5 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
6 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4 doxycycline;placebo
7 Efficacy & Safety Study of Pregabalin to Treat Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Unknown status NCT00371033 Phase 3 Pregabalin;Placebo
8 Efficacy Study of a Standardized Pollen Extract Preparation (Cernilton) to Treat Inflammatory Chronic Prostatitis-Chronic Pelvic Pain Syndrome (CP-CPPS) Completed NCT00919893 Phase 3 Cernilton;Placebo
9 Trial to Compare Alfuzosin Versus Placebo in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Completed NCT00103402 Phase 3 Alfuzosin
10 Efficacy Study of Acupuncture to Relieve Symptoms of Chronic Prostatitis Completed NCT00260637 Phase 2, Phase 3
11 Botulinum Toxin Type A for the Treatment of Male Chronic Pelvic Pain Syndrome Terminated NCT00464373 Phase 3 Botulinum Toxin Type A;Placebo
12 JALYN for Benign Prostatic Hyperplasia (BPH) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Terminated NCT01830829 Phase 3 Jalyn;Placebo
13 Laparoscopic Prostatectomy for Chronic Prostatitis Unknown status NCT00775515 Phase 2
14 Use of Silodosin to Treat Moderate to Severe Abacterial Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Completed NCT00740779 Phase 2 Silodosin 8 mg;Placebo;Silodosin 4 mg
15 An Open-Label Study of CC-10004 for Chronic Prostatitis/Chronic Pelvic Pain Syndrome Completed NCT00701311 Phase 2 CC-10004
16 Botox for Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Completed NCT00529386 Phase 2 Botox;Lidocaine
17 A Clinical Study to Investigate the Efficacy, Safety and Pharmacokinetics of ASP3652 in Patients With Chronic Abacterial Prostatitis / Chronic Pelvic Pain Syndrome (CP/CPPS) Completed NCT01391338 Phase 2 ASP3652;Placebo
18 An Efficacy And Safety Study Of Tanezumab For The Treatment Of Pain Associated With Chronic Abacterial Prostatitis Completed NCT00826514 Phase 2 Tanezumab;Placebo
19 Efficacy and Safety of AQX-1125 in Subjects With Chronic Prostatitis/Chronic Pelvic Pain Syndrome Recruiting NCT03500159 Phase 2 AQX-1125 200 mg;Placebo
20 Open-Label Study of Thalidomide for Chronic Prostatitis/Chronic Pelvic Pain Terminated NCT00301405 Phase 2 Thalidomide
21 Injection With OnabotulinumtoxinA (Botox) for the Treatment of Chronic Pelvic Pain Unknown status NCT02173405 Phase 1 OnabotulinumtoxinA;Placebo
22 Efficacy of Extracorporal Shock Wave Therapy in Patient With Chronic Non-bacterial Prostatitis / Chronic Pelvic Pain Syndrome Unknown status NCT01714830 Not Applicable
23 Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromE Unknown status NCT02033863
24 Shocking Therapy for Chronic Pelvic Pain Syndrome Unknown status NCT01828996 Not Applicable
25 Efficacy Study of Tamsulosin and Tolterodine Treatment for Chronic Prostatitis Unknown status NCT00913315 Not Applicable tolterodine;tamsulosin;placebo
26 Fibered Platinum Coils vs Vascular Plugs in Pelvic Varices Embolization for the Treatment of Pelvic Congestion Syndrome Completed NCT02796092 Not Applicable
27 Sono-Electro-Magnetic Therapy for Refractory Chronic Pelvic Pain Syndrome Completed NCT00710073 Not Applicable
28 Combined Sono-electro-magnetic Therapy for Treatment of Refractory Chronic Pelvic Pain Syndrome Completed NCT00688506 Not Applicable
29 Efficacy of Electromagnetic Stimulation Therapy for Chronic Prostatitis and Chronic Pelvic Pain Syndrome Completed NCT00922012 Not Applicable
30 Clinical Efficacy of Roxithromycin in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome Completed NCT01843946
31 Linkage Analysis in Interstitial Cystitis Completed NCT00675298
32 Physical Therapy Trial for Pelvic Pain Completed NCT00434343 Not Applicable
33 Diagnostic Challenges in IC (and Male CPPS) Completed NCT00672087
34 Observational Study of Control Participants for the MAPP Research Network Completed NCT01098292
35 Changes in Inflammatory and Contractile Protein Expression in Patients With Painful Bladder Syndrome/IC. Completed NCT00775281
36 Brain Effects of Sacral Neuromodulation Completed NCT00610064 Not Applicable
37 Pelvic Girdle Pain in a Pregnant Population in Western Norway. Completed NCT01098136 Not Applicable
38 Chronic Pelvic Pain Study of Individuals With Diagnoses or Symptoms of Interstitial Cystitis and/ or Chronic Prostatitis Completed NCT01098279
39 Histopathological Diagnosis of Adenomyosis Completed NCT02340533 Not Applicable
40 Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndrome Recruiting NCT03213938 Not Applicable
41 Embolization of Pelvic Veins in Treatment of Pelvic Congestion Syndrome Recruiting NCT03165214 Not Applicable
42 Efficacy of Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndromes Recruiting NCT02588274 Not Applicable
43 Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Recruiting NCT00499317
44 Embolization of Pelvic Varicosities in Patients With Pelvic Congestion Syndrome Recruiting NCT03057067 Not Applicable
45 Low-intensity Shockwave Therapy for Non-bacterial Prostatitis/Pelvic Pain Syndrome Recruiting NCT03543761 Not Applicable
46 Genetic Studies in Interstitial Cystitis (IC) Recruiting NCT00389142
47 Microbiomes of Pelvic Pain Recruiting NCT01738464
48 Mast Cells in Male Pelvic Pain and and Lower Urinary Tract Dysfunction Recruiting NCT03167216 Early Phase 1 Cromolyn Sodium;Cetirizine Hydrochloride
49 Chemokine Mechanisms in Chronic Pelvic Pain Recruiting NCT01676857
50 Trans-MAPP II Study of Urologic Chronic Pelvin Pain Recruiting NCT02898220

Search NIH Clinical Center for Taylor's Syndrome

Genetic Tests for Taylor's Syndrome

Anatomical Context for Taylor's Syndrome

MalaCards organs/tissues related to Taylor's Syndrome:

41
Prostate, Brain

Publications for Taylor's Syndrome

Articles related to Taylor's Syndrome:

# Title Authors Year
1
Embolization to treat pelvic congestion syndrome and vulval varicose veins. ( 22727416 )
2012
2
Gonadal vein embolization: treatment of varicocele and pelvic congestion syndrome. ( 21326516 )
2008

Variations for Taylor's Syndrome

Expression for Taylor's Syndrome

Search GEO for disease gene expression data for Taylor's Syndrome.

Pathways for Taylor's Syndrome

Pathways related to Taylor's Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 F2 KCNJ11

GO Terms for Taylor's Syndrome

Cellular components related to Taylor's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 CNTN3 F2 FLNA GNRH1 LY86 OVGP1

Biological processes related to Taylor's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.43 DNMT1 F2 GNRH1
2 response to testosterone GO:0033574 9.16 GNRH1 KCNJ11
3 DNA methylation GO:0006306 8.96 DNMT1 DNMT3L
4 DNA methylation on cytosine GO:0032776 8.62 DNMT1 DNMT3L

Molecular functions related to Taylor's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTPase binding GO:0051020 8.62 FLNA RASA1

Sources for Taylor's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....