MCID: TTH005
MIFTS: 22

Teeth Hard Tissue Disease

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Teeth Hard Tissue Disease

MalaCards integrated aliases for Teeth Hard Tissue Disease:

Name: Teeth Hard Tissue Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:214
ICD9CM 36 521.8 521.89
ICD10 34 K03.8 K03.89
UMLS 74 C0029770

Summaries for Teeth Hard Tissue Disease

MalaCards based summary : Teeth Hard Tissue Disease is related to dentin dysplasia and amelogenesis imperfecta, type ib. An important gene associated with Teeth Hard Tissue Disease is AMELX (Amelogenin X-Linked), and among its related pathways/superpathways is Osteoclast Signaling. Related phenotypes are craniofacial and growth/size/body region

Related Diseases for Teeth Hard Tissue Disease

Diseases related to Teeth Hard Tissue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 dentin dysplasia 11.1
2 amelogenesis imperfecta, type ib 10.4 AMBN ENAM
3 taurodontism 10.4 DLX3 DSPP
4 dentine erosion 10.3 AMBN TUFT1
5 amelogenesis imperfecta, type ie 10.3 AMELX TUFT1
6 dental pulp calcification 10.3 DSPP ENAM
7 dental pulp necrosis 10.3 AMBN AMELX DSPP
8 root caries 10.3 DSPP SMARCA2
9 dental pulp disease 10.3 AMELX DSPP
10 amelogenesis imperfecta hypomaturation type 10.3 AMELX MMP20 WDR72
11 dental abscess 10.2 ACP5 AMELX
12 brachyolmia 10.2 ENAM WDR72
13 tooth erosion 10.2 DSPP SMARCA2 TUFT1
14 dental fluorosis 10.2 AMBN AMELX DSPP MMP20
15 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 10.2 AMBN AMELX FAM83H TUFT1
16 hypoplastic amelogenesis imperfecta 10.2 AMBN DLX3 ENAM FAM20A
17 dental caries 10.2 AMELX DSPP ENAM TUFT1
18 ameloblastoma 10.2 AMBN MMP20 TNFSF11
19 villonodular synovitis 10.2 ACP5 TNFSF11
20 pigmented villonodular synovitis 10.1 ACP5 TNFSF11
21 hypercementosis 10.1 ACP5 DSPP ENAM FAM20A
22 periapical periodontitis 10.1 ACP5 DSPP TNFSF11
23 bone giant cell tumor 10.0 ACP5 TNFSF11
24 tooth resorption 10.0 ACP5 AMELX DSPP TNFSF11
25 gingival disease 10.0 FAM20A SMARCA2
26 amelogenesis imperfecta, type iiia 10.0 AMBN AMELX ENAM FAM83H MMP20 WDR72
27 glucocorticoid-induced osteoporosis 9.9 ACP5 TNFSF11
28 hypocalcified amelogenesis imperfecta 9.9 AMBN DSPP ENAM FAM83H MMP20 TUFT1
29 mouth disease 9.9 AMELX DEDD ENAM TNFSF11
30 amelogenesis imperfecta 9.5 AMBN AMELX CNNM4 DLX3 ENAM FAM20A

Graphical network of the top 20 diseases related to Teeth Hard Tissue Disease:



Diseases related to Teeth Hard Tissue Disease

Symptoms & Phenotypes for Teeth Hard Tissue Disease

MGI Mouse Phenotypes related to Teeth Hard Tissue Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.76 AMBN CNNM4 ENAM FAM20A FAM83H MMP20
2 growth/size/body region MP:0005378 9.73 AMBN CNNM4 DEDD DLX3 ENAM FAM20A
3 skeleton MP:0005390 9.23 AMBN CNNM4 ENAM FAM20A FAM83H SMARCA2

Drugs & Therapeutics for Teeth Hard Tissue Disease

Search Clinical Trials , NIH Clinical Center for Teeth Hard Tissue Disease

Genetic Tests for Teeth Hard Tissue Disease

Anatomical Context for Teeth Hard Tissue Disease

Publications for Teeth Hard Tissue Disease

Variations for Teeth Hard Tissue Disease

Expression for Teeth Hard Tissue Disease

Search GEO for disease gene expression data for Teeth Hard Tissue Disease.

Pathways for Teeth Hard Tissue Disease

Pathways related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.83 ACP5 TNFSF11

GO Terms for Teeth Hard Tissue Disease

Cellular components related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 AMBN AMELX CPQ DSPP ENAM FAM20A
2 extracellular matrix GO:0031012 9.02 AMELX DSPP ENAM MMP20 MMP25

Biological processes related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.61 ACP5 DSPP TNFSF11
2 odontogenesis of dentin-containing tooth GO:0042475 9.55 AMBN AMELX DLX3 ENAM ROGDI
3 calcium ion homeostasis GO:0055074 9.48 FAM20A TNFSF11
4 bone resorption GO:0045453 9.46 ACP5 TNFSF11
5 amelogenesis GO:0097186 9.4 ENAM MMP20
6 tooth eruption GO:0044691 9.37 FAM20A TNFSF11
7 odontoblast differentiation GO:0071895 9.32 DLX3 DSPP
8 biomineral tissue development GO:0031214 9.28 AMBN AMELX CNNM4 DSPP ENAM FAM20A
9 positive regulation of enamel mineralization GO:0070175 9.26 DSPP ENAM
10 enamel mineralization GO:0070166 9.26 AMELX CNNM4 FAM20A WDR72

Molecular functions related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 9.13 CPQ MMP20 MMP25
2 structural constituent of tooth enamel GO:0030345 8.92 AMBN AMELX ENAM TUFT1

Sources for Teeth Hard Tissue Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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