MCID: TTH005
MIFTS: 27

Teeth Hard Tissue Disease

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Teeth Hard Tissue Disease

MalaCards integrated aliases for Teeth Hard Tissue Disease:

Name: Teeth Hard Tissue Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:214
ICD9CM 34 521.8
SNOMED-CT 67 197505001
ICD10 32 K03.8 K03.9
UMLS 70 C0029770

Summaries for Teeth Hard Tissue Disease

MalaCards based summary : Teeth Hard Tissue Disease is related to dentin dysplasia and dental caries. An important gene associated with Teeth Hard Tissue Disease is ESR2 (Estrogen Receptor 2), and among its related pathways/superpathways are Estrogen signaling pathway (KEGG) and Nuclear Receptor transcription pathway. Affiliated tissues include breast, ovary and bone, and related phenotypes are growth/size/body region and craniofacial

Related Diseases for Teeth Hard Tissue Disease

Diseases related to Teeth Hard Tissue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 dentin dysplasia 32.4 MMP20 ENAM DSPP AMELX AMBN
2 dental caries 32.3 TUFT1 ENAM DSPP AMELX AMBN
3 nonmucinous bronchioloalveolar adenocarcinoma 10.5 ESR2 ESR1
4 glassy cell carcinoma of the cervix 10.5 PGR ESR1
5 breast intraductal papillomatosis 10.5 PGR ESR1
6 nipple carcinoma 10.5 PGR ESR1
7 bartholin's gland adenoma 10.5 PGR ESR1
8 bartholin's gland adenoid cystic carcinoma 10.5 PGR ESR1
9 uterine corpus adenosarcoma 10.5 PGR ESR1
10 bartholin's gland benign neoplasm 10.5 PGR ESR1
11 chronic tympanitis 10.5 PGR ESR1
12 bile duct cystadenoma 10.5 ESR2 ESR1
13 vestibular gland benign neoplasm 10.5 PGR ESR1
14 postmenopausal atrophic vaginitis 10.5 ESR2 ESR1
15 granulomatous endometritis 10.5 PGR ESR1
16 vulvar syringoma 10.5 PGR ESR1
17 lung leiomyoma 10.5 PGR ESR1
18 adult type testicular granulosa cell tumor 10.5 PGR ESR1
19 breast scirrhous carcinoma 10.5 PGR ESR1
20 subserous uterine fibroid 10.5 PGR CYP19A1
21 oncocytic breast carcinoma 10.5 PGR ESR1
22 amelogenesis imperfecta, type ic 10.5 MMP20 ENAM AMELX
23 cervical clear cell adenocarcinoma 10.5 PGR ESR1
24 ovarian seromucinous carcinoma 10.5 PGR ESR1
25 diffuse peritoneal leiomyomatosis 10.5 PGR CYP19A1
26 enamel erosion 10.5 MMP20 ERCC6 AMELX
27 papillary craniopharyngioma 10.5 MMP20 ENAM AMELX
28 progesterone resistance 10.5 PGR ESR2 ESR1
29 comedo carcinoma 10.5 PGR LCOR ESR1
30 vaginal cancer 10.5 PGR ESR2 ESR1
31 breast papillary carcinoma 10.5 PGR ESR1
32 mammographic density 10.5 ESR1 CYP19A1
33 liver leiomyoma 10.5 PGR ESR1
34 intravenous leiomyomatosis 10.5 PGR ESR1
35 hypoplastic amelogenesis imperfecta 10.5 FAM20A ENAM AMBN
36 lobular neoplasia 10.5 PGR ESR2 ESR1
37 tooth resorption 10.5 DSPP AMELX AMBN
38 breast adenoid cystic carcinoma 10.5 PGR ESR1
39 breast metaplastic carcinoma 10.5 PGR ESR1
40 intracranial meningioma 10.5 PGR ESR1
41 benign metastasizing leiomyoma 10.5 PGR CYP19A1
42 juvenile nasopharyngeal angiofibroma 10.5 PGR ESR1 CYP19A1
43 vulvar leiomyoma 10.5 PGR ESR1
44 vaginal discharge 10.5 PGR ESR1 CYP19A1
45 bizarre leiomyoma 10.5 PGR ESR1
46 hypertrophy of breast 10.5 PGR ESR1 CYP19A1
47 transsexualism 10.5 ESR2 CYP19A1
48 breast adenoma 10.5 PGR ESR1
49 myoma 10.5 PGR ESR1 CYP19A1
50 endometrial disease 10.5 PGR ESR1 CYP19A1

Graphical network of the top 20 diseases related to Teeth Hard Tissue Disease:



Diseases related to Teeth Hard Tissue Disease

Symptoms & Phenotypes for Teeth Hard Tissue Disease

MGI Mouse Phenotypes related to Teeth Hard Tissue Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10 AMBN AMTN CYP19A1 ENAM ERCC6 ESR1
2 craniofacial MP:0005382 9.8 AMBN AMTN ENAM FAM20A FAM83H MMP20
3 renal/urinary system MP:0005367 9.56 AMBN CYP19A1 ESR1 ESR2 ESRRG FAM20A
4 skeleton MP:0005390 9.4 AMBN AMTN CYP19A1 ENAM ERCC6 ESR1

Drugs & Therapeutics for Teeth Hard Tissue Disease

Search Clinical Trials , NIH Clinical Center for Teeth Hard Tissue Disease

Genetic Tests for Teeth Hard Tissue Disease

Anatomical Context for Teeth Hard Tissue Disease

MalaCards organs/tissues related to Teeth Hard Tissue Disease:

40
Breast, Ovary, Bone, Cervix, Liver, Lung, Prostate

Publications for Teeth Hard Tissue Disease

Variations for Teeth Hard Tissue Disease

Expression for Teeth Hard Tissue Disease

Search GEO for disease gene expression data for Teeth Hard Tissue Disease.

Pathways for Teeth Hard Tissue Disease

Pathways related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 PGR GPER1 ESR2 ESR1
2
Show member pathways
11.21 PGR ESRRG ESR2 ESR1
3 10.84 PGR ESR2 CYP19A1
4 9.4 ESR2 ESR1 CYP19A1

GO Terms for Teeth Hard Tissue Disease

Cellular components related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 TUFT1 MMP25 MMP20 FAM20A ENAM DSPP
2 endoplasmic reticulum lumen GO:0005788 9.46 ENAM AMTN AMELX AMBN
3 extracellular matrix GO:0031012 9.1 MMP25 MMP20 ENAM DSPP AMTN AMELX

Biological processes related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.78 ENAM AMTN AMELX AMBN
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.71 PGR ESRRG ESR2 ESR1
3 odontogenesis of dentin-containing tooth GO:0042475 9.61 AMTN AMELX AMBN
4 cellular response to estradiol stimulus GO:0071392 9.56 LCOR GPER1 ESR2 ESR1
5 enamel mineralization GO:0070166 9.5 WDR72 FAM20A AMELX
6 amelogenesis GO:0097186 9.46 MMP20 ENAM
7 steroid hormone mediated signaling pathway GO:0043401 9.46 PGR GPER1 ESRRG ESR1
8 positive regulation of enamel mineralization GO:0070175 9.37 ENAM AMTN
9 biomineral tissue development GO:0031214 9.28 WDR72 TUFT1 FAM83H FAM20A ENAM DSPP
10 intracellular steroid hormone receptor signaling pathway GO:0030518 9.26 PGR GPER1 ESR2 ESR1

Molecular functions related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.91 PGR MMP25 MMP20 ESRRG ESR2 ESR1
2 sequence-specific DNA binding GO:0043565 9.8 PGR ESRRG ESR2 ESR1 ERCC6
3 nuclear receptor activity GO:0004879 9.62 PGR ESRRG ESR2 ESR1
4 steroid binding GO:0005496 9.55 PGR GPER1 ESRRG ESR2 ESR1
5 RNA polymerase II transcription corepressor binding GO:0001226 9.46 LCOR ESR1
6 estrogen receptor activity GO:0030284 9.43 GPER1 ESR2 ESR1
7 estrogen response element binding GO:0034056 9.37 ESR2 ESR1
8 structural constituent of tooth enamel GO:0030345 9.26 TUFT1 ENAM AMELX AMBN
9 steroid hormone receptor activity GO:0003707 9.02 PGR GPER1 ESRRG ESR2 ESR1

Sources for Teeth Hard Tissue Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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