MCID: TTH005
MIFTS: 22

Teeth Hard Tissue Disease

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Teeth Hard Tissue Disease

MalaCards integrated aliases for Teeth Hard Tissue Disease:

Name: Teeth Hard Tissue Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:214
ICD10 33 K03.8 K03.89
ICD9CM 35 521.8 521.89
SNOMED-CT 68 197505001
UMLS 73 C0029770

Summaries for Teeth Hard Tissue Disease

MalaCards based summary : Teeth Hard Tissue Disease is related to dentin dysplasia and enamel caries. An important gene associated with Teeth Hard Tissue Disease is AMELX (Amelogenin X-Linked), and among its related pathways/superpathways is Osteoclast Signaling. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Teeth Hard Tissue Disease

Diseases related to Teeth Hard Tissue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 dentin dysplasia 10.9
2 enamel caries 10.8 AMELX AMELY
3 epulis 10.7 AMELX AMELY
4 taurodontism 10.7 DLX3 DSPP
5 freemartinism 10.7 AMELX AMELY
6 retinitis pigmentosa 59 10.7 AMELX AMELY
7 dental fluorosis 10.6 AMELX DSPP MMP20
8 dentin caries 10.6 DSPP GPI
9 dental pulp calcification 10.6 DSPP ENAM
10 amelogenesis imperfecta, type ie 10.6 AMELX AMELY TUFT1
11 amelogenesis imperfecta, type ib 10.5 AMBN ENAM
12 enamel erosion 10.5 GPI SMARCA2
13 dental pulp necrosis 10.4 AMBN AMELX AMELY DSPP
14 dentine erosion 10.4 AMBN GPI TUFT1
15 amelogenesis imperfecta hypomaturation type 10.4 AMELX MMP20 WDR72
16 root caries 10.3 DSPP GPI SMARCA2
17 dental caries 10.3 AMELX DSPP ENAM TUFT1
18 hypoplastic amelogenesis imperfecta 10.3 AMBN DLX3 ENAM FAM20A
19 dental abscess 10.3 ACP5 AMELX
20 gingival disease 10.3 FAM20A GPI SMARCA2
21 ameloblastoma 10.3 AMBN MMP20 TNFSF11
22 villonodular synovitis 10.2 ACP5 TNFSF11
23 hypercementosis 10.1 ACP5 DSPP ENAM FAM20A
24 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 10.1 AMBN AMELX AMELY FAM83H TUFT1
25 tooth erosion 10.1 DSPP GPI SMARCA2 TUFT1
26 periapical periodontitis 10.1 ACP5 DSPP TNFSF11
27 tooth resorption 9.9 ACP5 AMELX DSPP TNFSF11
28 hypocalcified amelogenesis imperfecta 9.8 AMBN DSPP ENAM FAM83H MMP20 TUFT1
29 multicentric carpotarsal osteolysis syndrome 9.8 ACP5 TNFSF11
30 amelogenesis imperfecta, type iiia 9.7 AMBN AMELX ENAM FAM83H MMP20 WDR72
31 pigmented villonodular synovitis 9.6 ACP5 TNFSF11
32 mouth disease 9.6 AMELX AMELY DEDD ENAM TNFSF11
33 amelogenesis imperfecta 8.5 AMBN AMELX AMELY CNNM4 DLX3 ENAM

Graphical network of the top 20 diseases related to Teeth Hard Tissue Disease:



Diseases related to Teeth Hard Tissue Disease

Symptoms & Phenotypes for Teeth Hard Tissue Disease

GenomeRNAi Phenotypes related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 10.05 DSPP
2 Decreased viability GR00381-A-1 10.05 DSPP MMP25 TUFT1
3 Decreased viability GR00381-A-3 10.05 TUFT1
4 Decreased viability GR00402-S-2 10.05 ACP5 AMBN AMELX AMELY CNNM4 CPQ
5 no effect GR00402-S-1 9.62 TUFT1 WDR72 ACP5 AMBN AMELX AMELY

MGI Mouse Phenotypes related to Teeth Hard Tissue Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.77 AMBN AMELY CNNM4 DEDD DLX3 ENAM
2 craniofacial MP:0005382 9.76 MMP20 TNFSF11 WDR72 AMBN AMELY CNNM4
3 skeleton MP:0005390 9.23 AMBN AMELY CNNM4 ENAM FAM20A SMARCA2

Drugs & Therapeutics for Teeth Hard Tissue Disease

Search Clinical Trials , NIH Clinical Center for Teeth Hard Tissue Disease

Genetic Tests for Teeth Hard Tissue Disease

Anatomical Context for Teeth Hard Tissue Disease

Publications for Teeth Hard Tissue Disease

Variations for Teeth Hard Tissue Disease

Expression for Teeth Hard Tissue Disease

Search GEO for disease gene expression data for Teeth Hard Tissue Disease.

Pathways for Teeth Hard Tissue Disease

Pathways related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.83 ACP5 TNFSF11

GO Terms for Teeth Hard Tissue Disease

Cellular components related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.36 AMBN AMELX CPQ DSPP ENAM FAM20A

Biological processes related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 odontogenesis of dentin-containing tooth GO:0042475 9.46 AMBN AMELX DLX3 ENAM
2 calcium ion homeostasis GO:0055074 9.43 FAM20A TNFSF11
3 bone resorption GO:0045453 9.4 ACP5 TNFSF11
4 amelogenesis GO:0097186 9.37 ENAM MMP20
5 tooth eruption GO:0044691 9.32 FAM20A TNFSF11
6 biomineral tissue development GO:0031214 9.32 AMBN AMELX AMELY CNNM4 DSPP ENAM
7 tooth mineralization GO:0034505 9.26 AMELX AMELY
8 enamel mineralization GO:0070166 9.26 AMELX CNNM4 FAM20A WDR72

Molecular functions related to Teeth Hard Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of tooth enamel GO:0030345 9.02 AMBN AMELX AMELY ENAM TUFT1

Sources for Teeth Hard Tissue Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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