MCID: TTH030
MIFTS: 32

Teeth, Supernumerary

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Teeth, Supernumerary

MalaCards integrated aliases for Teeth, Supernumerary:

Name: Teeth, Supernumerary 57 29 6
Supernumerary Teeth 54 32

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant


HPO:

31
teeth, supernumerary:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 187100
ICD10 32 K00.1
MedGen 41 C0040457

Summaries for Teeth, Supernumerary

MalaCards based summary : Teeth, Supernumerary, also known as supernumerary teeth, is related to root resorption and tooth agenesis. An important gene associated with Teeth, Supernumerary is LEMD2 (LEM Domain Nuclear Envelope Protein 2). Affiliated tissues include bone, eye and pituitary, and related phenotypes are increased number of teeth and mesiodens

Wikipedia : 73 Hyperdontia is the condition of having supernumerary teeth, or teeth that appear in addition to the... more...

More information from OMIM: 187100

Related Diseases for Teeth, Supernumerary

Diseases related to Teeth, Supernumerary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 root resorption 30.2 RUNX2 DSPP
2 tooth agenesis 29.6 RUNX2 DSPP
3 craniosynostosis and dental anomalies 11.3
4 cleidocranial dysplasia 11.2
5 glass syndrome 11.0
6 marbach-rustad progeroid syndrome 11.0
7 orofaciodigital syndrome 12 11.0
8 hair whorl 10.6
9 cleidocranial dysplasia spectrum disorder 10.5
10 odontoma 10.4
11 dysostosis 10.4
12 cleft lip 10.4
13 familial adenomatous polyposis 1 10.3
14 trichorhinophalangeal syndrome, type i 10.3
15 periodontitis 10.3
16 cleft lip/palate 10.3
17 teeth, fused 10.2
18 ehlers-danlos syndrome 10.2
19 anodontia 10.2
20 trichorhinophalangeal syndrome 10.2
21 cleft palate, isolated 10.1
22 ellis-van creveld syndrome 10.1
23 fabry disease 10.1
24 nance-horan syndrome 10.1
25 otopalatodigital syndrome, type i 10.1
26 tooth size 10.1
27 chromosome 16p13.3 deletion syndrome, proximal 10.1
28 familial adenomatous polyposis 10.1
29 hypertelorism 10.1
30 hallermann-streiff syndrome 10.1
31 taurodontism 10.1
32 microphthalmia, syndromic 2 10.1
33 impacted teeth, multiple 10.1
34 robinow syndrome 10.1
35 gingival fibromatosis 10.1
36 aggressive periodontitis 10.1
37 dental caries 10.1
38 ankylosis 10.1
39 craniosynostosis 10.1
40 gingival overgrowth 10.1
41 fibromatosis 10.1
42 zimmermann-laband syndrome 10.1
43 achondroplasia 9.9
44 sotos syndrome 1 9.9
45 crouzon syndrome 9.9
46 fibromatosis, gingival, 1 9.9
47 fibrosis of extraocular muscles, congenital, 1 9.9
48 lentigines 9.9
49 marfan syndrome 9.9
50 teeth present at birth 9.9

Graphical network of the top 20 diseases related to Teeth, Supernumerary:



Diseases related to Teeth, Supernumerary

Symptoms & Phenotypes for Teeth, Supernumerary

Human phenotypes related to Teeth, Supernumerary:

31
# Description HPO Frequency HPO Source Accession
1 increased number of teeth 31 HP:0011069
2 mesiodens 31 HP:0011067

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Teeth:
mesiodens
supernumerary teeth

Clinical features from OMIM®:

187100 (Updated 20-May-2021)

Drugs & Therapeutics for Teeth, Supernumerary

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevalence of Erupted Supernumerary Teeth Among a Group of Egyptian Children Aged From Six to Fifteen Years Old: a Cross Sectional Study Completed NCT03650634
2 Exact Three-dimensional Localisation of Impacted and Supernumerary Teeth by Cone Beam Computer Tomography Completed NCT01002131

Search NIH Clinical Center for Teeth, Supernumerary

Genetic Tests for Teeth, Supernumerary

Genetic tests related to Teeth, Supernumerary:

# Genetic test Affiliating Genes
1 Teeth, Supernumerary 29

Anatomical Context for Teeth, Supernumerary

MalaCards organs/tissues related to Teeth, Supernumerary:

40
Bone, Eye, Pituitary, Bone Marrow, Tongue, Kidney

Publications for Teeth, Supernumerary

Articles related to Teeth, Supernumerary:

(show top 50) (show all 1350)
# Title Authors PMID Year
1
A rare case of hereditary multiple impacted normal and supernumerary teeth. 57 61
10023236 1998
2
Mesiodens, a new microform of holoprosencephaly? 57
19161155 2009
3
Diversity of supernumerary tooth formation in siblings with cleidocranial dysplasia having identical mutation in RUNX2 : possible involvement of non-genetic or epigenetic regulation. 54 61
17973689 2007
4
Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia. 54 61
10521292 1999
5
Analysis of the distribution of supernumerary teeth and the characteristics of mesiodens in Bengbu, China: a retrospective study. 61
32198663 2021
6
Should we floss our nose? A case report of a tooth in the nasal cavity. 61
33752294 2021
7
Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling. 61
33579703 2021
8
Ectopic eruption of the first permanent molar: Predictive factors for irreversible outcome. 61
33546831 2021
9
Prevalence of hypodontia and supernumerary teeth in a German cleft lip with/without palate population. 61
33573652 2021
10
Supernumerary Teeth and Dental Development. 61
33538447 2021
11
Dental anomalies frequency in submucous cleft palate versus complete cleft palate. 61
33615332 2021
12
Dental Subphenotypes in Infants With Orofacial Clefts-A Longitudinal Population-Based Retrospective Radiographic Study of the Primary and Secondary Dentitions. 61
33541114 2021
13
A case report of cleidocranial dysplasia: A noninvasive approach. 61
33080065 2021
14
Epidemiology of Supernumerary Teeth in 5000 Radiography Films: Investigation of Patients Referring to the Clinics of Ardabil in 2015-2020. 61
33688347 2021
15
Specific oral and maxillofacial identifiers in panoramic radiographs used for human identification. 61
33506528 2021
16
Guiding Maxillary Left Central Incisor to Occlusion and Late Formation of a Supernumerary Tooth in the Upper Left Premolar Region. 61
33628523 2021
17
An Epidemiological Study on Orodental Disorders in 3,791 Working Donkeys in Egypt: Prevalence and Risk Factors. 61
33276917 2020
18
Use of 3D printing in the planning of a patient with unerupted maxillary central incisors. 61
33325266 2020
19
Epidemiological, clinical, and 3-dimentional CBCT radiographic characterizations of supernumerary teeth in a non-syndromic adult population: a single-institutional study from 60,104 Chinese subjects. 61
32333176 2020
20
Spontaneous eruption of impacted maxillary incisors after surgical extraction of supernumerary teeth: a systematic review and meta-analysis. 61
32488485 2020
21
Validation of a three-dimensional printed model for training of surgical extraction of supernumerary teeth. 61
32402151 2020
22
Frequency of Additional Congenital Dental Anomalies in Children with Cleft Lip, Alveolar and Palate. 61
33255766 2020
23
Association between Dental Anomalies and Orofacial Clefts: A Meta-analysis. 61
33030085 2020
24
Multidisciplinary management of delayed eruption of permanent mandibular first molar associated with dentigerous cyst. 61
33402628 2020
25
Deep learning systems for detecting and classifying the presence of impacted supernumerary teeth in the maxillary incisor region on panoramic radiographs. 61
32507560 2020
26
Epidemiological, clinical, radiographic characterization of non-syndromic supernumerary teeth in Chinese children and adolescents. 61
32881166 2020
27
Associations of the microRNA gene polymorphisms with the risk of non-syndromic supernumerary teeth in a Chinese population. 61
32562900 2020
28
Complications associated with specific characteristics of supernumerary teeth. 61
32386819 2020
29
Impaired dentin mineralization, supernumerary teeth, hypoplastic mandibular condyles with long condylar necks, and a TRPS1 mutation. 61
32442662 2020
30
Non-syndromal multiple supernumerary and permanent impacted teeth in mother and her one child. 61
32847888 2020
31
Prevalence of Common Clinically Manifested Developmental Anomalies of the Oral Cavity Among Adults - An Epidemiological Study in a South Indian Population. 61
32983665 2020
32
Oncostatin M enhances osteogenic differentiation of dental pulp stem cells derived from supernumerary teeth. 61
32703406 2020
33
Prevalence of Dental Anomalies in the Patient with Cleft Lip and Palate Visiting a Tertiary Care Hospital. 61
32968294 2020
34
THOC6 Intellectual Disability Syndrome 61
32790266 2020
35
Chronic odontogenic nasal discharge: report of two cases. 61
32705696 2020
36
FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. 61
32664967 2020
37
Three-dimensional evaluation of morphology and position of impacted supernumerary teeth in cases of cleidocranial dysplasia. 61
31599034 2020
38
Supernumerary maxillary fourth premolar teeth in five related Burmese cats. 61
33149928 2020
39
TRPS1 mutation associated with trichorhinophalangeal syndrome type 1 with 15 supernumerary teeth, hypoplastic mandibular condyles with slender condylar necks and unique hair morphology. 61
32347565 2020
40
Surgical Management of Unerupted Permanent Maxillary Central Incisors Due to Presence of Two Supernumerary Teeth. 61
33149418 2020
41
Epidemiological Features and Clinical Repercussions of Supernumerary Teeth in a Multicenter Study: A Review of 518 Patients with Hyperdontia in Spanish Population. 61
32542632 2020
42
Imaging characteristics of Gubernacular Tract on CBCT- A pictorial review. 61
32607940 2020
43
Dental disorders in sows from Swedish commercial herds. 61
32498715 2020
44
[Application of digital positioning guide plate in extraction of impacted supernumerary teeth]. 61
32895197 2020
45
An unusual presentation of supernumerary teeth in the mastoid bone. 61
32224007 2020
46
Inverted Supernumerary Intranasal Teeth as Unusual Indications of Endoscopic Surgery. 61
32596178 2020
47
A rare case of accessory maxilla: a case report and literature review of Tessier no. 7 clefts. 61
32436459 2020
48
Developmental dental anomalies assessed by panoramic radiographs in a Greek orthodontic population sample. 61
31494863 2020
49
A combination of kissing molars, maxillary bilateral supernumerary teeth and macrodontia: a rare case report. 61
32299406 2020
50
Oral and Dental Examination Findings in European Polecats (Mustela putorius). 61
32359635 2020

Variations for Teeth, Supernumerary

ClinVar genetic disease variations for Teeth, Supernumerary:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 LEMD2 NM_181336.4(LEMD2):c.1436C>T (p.Ser479Phe) SNV Likely pathogenic 917488 GRCh37: 6:33740481-33740481
GRCh38: 6:33772704-33772704

Expression for Teeth, Supernumerary

Search GEO for disease gene expression data for Teeth, Supernumerary.

Pathways for Teeth, Supernumerary

GO Terms for Teeth, Supernumerary

Biological processes related to Teeth, Supernumerary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 8.96 RUNX2 DSPP
2 ossification GO:0001503 8.62 RUNX2 DSPP

Sources for Teeth, Supernumerary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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