MCID: TLN002
MIFTS: 27

Telangiectatic Osteogenic Sarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Telangiectatic Osteogenic Sarcoma

MalaCards integrated aliases for Telangiectatic Osteogenic Sarcoma:

Name: Telangiectatic Osteogenic Sarcoma 12 15
Telangiectatic Osteosarcoma 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6951
NCIt 50 C3902
SNOMED-CT 68 78453009
UMLS 73 C0259782

Summaries for Telangiectatic Osteogenic Sarcoma

MalaCards based summary : Telangiectatic Osteogenic Sarcoma, also known as telangiectatic osteosarcoma, is related to osteogenic sarcoma and sarcoma, and has symptoms including pain An important gene associated with Telangiectatic Osteogenic Sarcoma is MAP7D3 (MAP7 Domain Containing 3). The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include bone, lymph node and spinal cord, and related phenotypes are Decreased shRNA abundance and Decreased shRNA abundance

Related Diseases for Telangiectatic Osteogenic Sarcoma

Diseases related to Telangiectatic Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 osteogenic sarcoma 10.6
2 sarcoma 10.6
3 aneurysmal bone cysts 10.4
4 chondrosarcoma 10.2
5 angiosarcoma 10.2
6 juxtacortical osteosarcoma 10.2
7 adenocarcinoma 10.0
8 thoracic outlet syndrome 10.0

Graphical network of the top 20 diseases related to Telangiectatic Osteogenic Sarcoma:



Diseases related to Telangiectatic Osteogenic Sarcoma

Symptoms & Phenotypes for Telangiectatic Osteogenic Sarcoma

UMLS symptoms related to Telangiectatic Osteogenic Sarcoma:


pain

GenomeRNAi Phenotypes related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00251-A-1 9.4 CYP4V2 MAP7D3 USP6
2 Decreased shRNA abundance GR00251-A-2 9.4 CYP4V2 MAP7D3 USP6
3 Decreased p24 protein expression GR00163-A-1 8.96 H3F3A USP6

Drugs & Therapeutics for Telangiectatic Osteogenic Sarcoma

Drugs for Telangiectatic Osteogenic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Serotonin Agents Phase 3
4 Anti-Allergic Agents Phase 3
5 Serotonin Antagonists Phase 3
6 Histamine H1 Antagonists Phase 3
7
Histamine Phosphate Phase 3 51-74-1 65513
8 Antipruritics Phase 3
9 Neurotransmitter Agents Phase 3
10 Dermatologic Agents Phase 3
11 Histamine Antagonists Phase 3
12 Gastrointestinal Agents Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
15 Immunosuppressive Agents Phase 2
16 Angiogenesis Modulating Agents Phase 2
17 Angiogenesis Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate

Search NIH Clinical Center for Telangiectatic Osteogenic Sarcoma

Genetic Tests for Telangiectatic Osteogenic Sarcoma

Anatomical Context for Telangiectatic Osteogenic Sarcoma

MalaCards organs/tissues related to Telangiectatic Osteogenic Sarcoma:

41
Bone, Lymph Node, Spinal Cord

Publications for Telangiectatic Osteogenic Sarcoma

Articles related to Telangiectatic Osteogenic Sarcoma:

(show top 50) (show all 63)
# Title Authors Year
1
Primary appendicular hemangiosarcoma and telangiectatic osteosarcoma in 70 dogs: A Veterinary Society of Surgical Oncology retrospective study. ( 30051473 )
2018
2
Identification of probable telangiectatic osteosarcoma from a dog skull from multicultural settlement Polwica-Skrzypnik in Lower Silesia, Poland. ( 30139695 )
2018
3
Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst. ( 29892520 )
2018
4
Telangiectatic osteosarcoma and renal adenocarcinoma in an Oscar (Astronotus ocellatus, Agassiz): Diagnostic imaging and immunohistochemical study. ( 29572933 )
2018
5
Use of routine histopathology and factor VIII-related antigen/von Willebrand factor immunohistochemistry to differentiate primary hemangiosarcoma of bone from telangiectatic osteosarcoma in 54 dogs. ( 27507032 )
2017
6
Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta). ( 28185292 )
2017
7
Central Telangiectatic Osteosarcoma of the Mandible in a Paediatric Patient: A Rarity. ( 28208989 )
2016
8
Telangiectatic osteosarcoma: a review of 87 cases. ( 27469493 )
2016
9
Telangiectatic osteosarcoma of the rib: a rare entity and a potential diagnostic pitfall. ( 28195259 )
2016
10
FROM ANEURYSMAL BONE CYST TO TELANGIECTATIC OSTEOSARCOMA WITH METASTASIS IN INGUINAL LYMPH NODES - CASE REPORT. ( 26214993 )
2015
11
Preoperative easily misdiagnosed telangiectatic osteosarcoma: clinical-radiologic-pathologic correlations. ( 24334494 )
2013
12
Aggressive aneurysmal bone cyst of the maxilla confused with telangiectatic osteosarcoma. ( 21862268 )
2012
13
Primary telangiectatic osteosarcoma of the cervical spine. ( 22225487 )
2012
14
Telangiectatic osteosarcoma. ( 22540307 )
2012
15
Telangiectatic osteosarcoma: Pathological rarity and scintigraphic exclusivity. ( 23599606 )
2012
16
Primary telangiectatic osteosarcoma of occipital bone: a case report and review of literature. ( 21339678 )
2011
17
Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. ( 19826810 )
2010
18
Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. ( 19271217 )
2009
19
Telangiectatic osteosarcoma: radiologic and pathologic findings. ( 19325054 )
2009
20
Plain X-ray, computed tomography and magnetic resonance imaging findings of telangiectatic osteosarcoma: a case report. ( 19918488 )
2009
21
Telangiectatic osteosarcoma of the spine: a case report. ( 18421481 )
2008
22
Telangiectatic osteosarcoma of the patella. ( 19292411 )
2008
23
Complete segmental resection of the spine, including the spinal cord, for telangiectatic osteosarcoma: a report of 2 cases. ( 16481940 )
2006
24
Dedifferentiated chondrosarcoma with telangiectatic osteosarcoma-like features. ( 17071806 )
2006
25
Five-year evolution of a telangiectatic osteosarcoma initially managed as an aneurysmal bone cyst. ( 15570421 )
2005
26
Primary pelvic telangiectatic osteosarcoma metastatic to both orbits. ( 14752317 )
2004
27
Vertebral telangiectatic osteosarcoma in a dog. ( 15334352 )
2004
28
Oral metastasis of telangiectatic osteosarcoma. ( 12657038 )
2003
29
Telangiectatic osteosarcoma of the clavicle: case report. ( 12866244 )
2003
30
Telangiectatic osteosarcoma: a clinicopathologic analysis of 14 cases. ( 12475437 )
2002
31
Multicentric telangiectatic osteosarcoma. ( 11328536 )
2001
32
Telangiectatic osteosarcoma of the extremity: neoadjuvant chemotherapy in 24 cases. ( 11372948 )
2001
33
Post-Paget telangiectatic osteosarcoma of the skull. ( 10486018 )
1999
34
Dedifferentiated chondrosarcoma with features of telangiectatic osteosarcoma. ( 10643020 )
1999
35
Telangiectatic osteosarcoma of the skull base. ( 9576668 )
1998
36
Local recurrence of a phyllodes tumour of the breast presenting with widespread differentiation to a telangiectatic osteosarcoma. ( 9930079 )
1998
37
Telangiectatic osteosarcoma of the skull. A post-Paget case. ( 9266145 )
1997
38
An unusual presentation of telangiectatic osteosarcoma. ( 8727089 )
1996
39
Primary chemotherapy and delayed surgery for non-metastatic telangiectatic osteosarcoma of the extremities. Results in 28 patients. ( 8080676 )
1994
40
Familial occurrence of telangiectatic osteosarcoma: cousin cases. ( 8113361 )
1994
41
Extraskeletal telangiectatic osteosarcoma. ( 8490830 )
1993
42
Telangiectatic osteogenic sarcoma: an unusual presentation. ( 1400148 )
1992
43
Telangiectatic osteogenic sarcoma of the extremities. Results in 17 patients treated with neoadjuvant chemotherapy. ( 1884565 )
1991
44
Telangiectatic osteosarcoma. ( 1884532 )
1991
45
Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for telangiectatic osteogenic sarcoma of the extremities. ( 2477510 )
1989
46
Telangiectatic osteosarcoma--a case report. ( 2597366 )
1989
47
Effectiveness of chemotherapy in the management of metastatic telangiectatic osteosarcoma. ( 3162788 )
1988
48
High alkaline phosphatase activity of telangiectatic osteosarcoma (TOS) and its diagnostic significance. ( 3474863 )
1987
49
The radiological appearances of telangiectatic osteosarcoma. A study of 14 cases. ( 3473690 )
1987
50
Telangiectatic osteogenic sarcoma. Improved survival with combination chemotherapy. ( 2424660 )
1986

Variations for Telangiectatic Osteogenic Sarcoma

Expression for Telangiectatic Osteogenic Sarcoma

Search GEO for disease gene expression data for Telangiectatic Osteogenic Sarcoma.

Pathways for Telangiectatic Osteogenic Sarcoma

GO Terms for Telangiectatic Osteogenic Sarcoma

Sources for Telangiectatic Osteogenic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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