MCID: TLN002
MIFTS: 27

Telangiectatic Osteogenic Sarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Telangiectatic Osteogenic Sarcoma

MalaCards integrated aliases for Telangiectatic Osteogenic Sarcoma:

Name: Telangiectatic Osteogenic Sarcoma 12 15
Telangiectatic Osteosarcoma 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6951
NCIt 49 C3902
SNOMED-CT 67 78453009
UMLS 71 C0259782

Summaries for Telangiectatic Osteogenic Sarcoma

MalaCards based summary : Telangiectatic Osteogenic Sarcoma, also known as telangiectatic osteosarcoma, is related to aneurysmal bone cysts and juxtacortical osteosarcoma, and has symptoms including pain An important gene associated with Telangiectatic Osteogenic Sarcoma is USP6 (Ubiquitin Specific Peptidase 6). The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include bone, lymph node and spinal cord.

Related Diseases for Telangiectatic Osteogenic Sarcoma

Diseases related to Telangiectatic Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 aneurysmal bone cysts 30.6 USP6 CDH11
2 juxtacortical osteosarcoma 30.4 MDM2 COPS3
3 bone osteosarcoma 30.1 USP6 MDM2 COPS3
4 osteogenic sarcoma 30.0 MDM2 LINC00901 COPS3 CDH11
5 osteoblastoma 29.9 USP6 THRAP3 CDH11
6 angiosarcoma 29.2 MDM2 CAMTA1
7 sarcoma 10.6
8 spindle cell sarcoma 10.6
9 chondrosarcoma 10.2
10 pneumothorax 10.2
11 myositis ossificans 10.1 USP6 MDM2
12 peripheral osteosarcoma 10.1 MDM2 COPS3
13 torticollis 10.1
14 chordoma 10.1
15 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
16 bone disease 10.1
17 fibrous dysplasia 10.1
18 bone cancer 10.1
19 hemangioma 10.1
20 cystic teratoma 10.1
21 adenocarcinoma 10.1
22 teratoma 10.1
23 mesenchymal cell neoplasm 10.1
24 mammary paget's disease 10.1
25 paraplegia 10.1
26 exophthalmos 10.1
27 47,xyy 10.1
28 osteochondroma 10.1
29 rare tumor 10.1
30 ossifying fibroma 10.0 USP6 MDM2
31 connective tissue benign neoplasm 10.0 USP6 MDM2
32 bone giant cell tumor 10.0 USP6 H3-3B
33 familial retinoblastoma 10.0 PRIM1 MDM2
34 chondroblastoma 9.9 USP6 H3-3B
35 conventional central osteosarcoma 9.9 USP6 MDM2 COPS3
36 benign giant cell tumor 9.9 USP6 H3-3B
37 pseudosarcomatous fibromatosis 9.9 USP6 THRAP3 CDH11
38 proliferative fasciitis 9.9 USP6 CAMTA1
39 giant cell glioblastoma 9.7 MDM2 H3-3B

Graphical network of the top 20 diseases related to Telangiectatic Osteogenic Sarcoma:



Diseases related to Telangiectatic Osteogenic Sarcoma

Symptoms & Phenotypes for Telangiectatic Osteogenic Sarcoma

UMLS symptoms related to Telangiectatic Osteogenic Sarcoma:


pain

Drugs & Therapeutics for Telangiectatic Osteogenic Sarcoma

Drugs for Telangiectatic Osteogenic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Neurotransmitter Agents Phase 3
4 Histamine Antagonists Phase 3
5 Anti-Allergic Agents Phase 3
6
Histamine Phosphate Phase 3 51-74-1 65513
7 Histamine H1 Antagonists Phase 3
8 Dermatologic Agents Phase 3
9 Gastrointestinal Agents Phase 3
10
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
11
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
12 Protein Kinase Inhibitors Phase 2
13 Immunosuppressive Agents Phase 2
14 Angiogenesis Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 A Multicenter Phase II Study of Continuous Dosing of Sunitinib (Sutent®, SU11248) in Non-GIST Sarcomas Completed NCT00474994 Phase 2 sunitinib malate

Search NIH Clinical Center for Telangiectatic Osteogenic Sarcoma

Genetic Tests for Telangiectatic Osteogenic Sarcoma

Anatomical Context for Telangiectatic Osteogenic Sarcoma

MalaCards organs/tissues related to Telangiectatic Osteogenic Sarcoma:

40
Bone, Lymph Node, Spinal Cord, Breast, Ovary, Testes

Publications for Telangiectatic Osteogenic Sarcoma

Articles related to Telangiectatic Osteogenic Sarcoma:

(show top 50) (show all 125)
# Title Authors PMID Year
1
Evaluation of factors affecting survival rate in primary bone sarcomas with extremity and pelvis involvement. 61
32544060 2020
2
The differentiation between aneurysmal bone cyst and telangiectatic osteosarcoma: a clinical, radiographic and MRI study. 61
32248448 2020
3
Validation of Fluorescence in situ Hybridization Testing of USP6 Gene Rearrangement for Diagnosis of Primary Aneurysmal Bone Cyst. 61
31611201 2019
4
Identification of probable telangiectatic osteosarcoma from a dog skull from multicultural settlement Polwica-Skrzypnik in Lower Silesia, Poland. 61
30139695 2019
5
Primary appendicular hemangiosarcoma and telangiectatic osteosarcoma in 70 dogs: A Veterinary Society of Surgical Oncology retrospective study. 61
30051473 2018
6
Telangiectatic osteosarcoma and renal adenocarcinoma in an Oscar (Astronotus ocellatus, Agassiz): Diagnostic imaging and immunohistochemical study. 61
29572933 2018
7
Capillary Hemangioma as an Unusual Cause of Doughnut Sign on Bone Scan. 61
29742594 2018
8
Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst. 61
29892520 2018
9
Is Core Needle Biopsy Reliable in Differentiating Between Aggressive Benign and Malignant Radiolucent Bone Tumors? 61
29529643 2018
10
Use of routine histopathology and factor VIII-related antigen/von Willebrand factor immunohistochemistry to differentiate primary hemangiosarcoma of bone from telangiectatic osteosarcoma in 54 dogs. 61
27507032 2017
11
Prognostic factors and survival rate of osteosarcoma: A single-institution study. 61
25870979 2017
12
Diagnosing and discriminating between primary and secondary aneurysmal bone cysts. 61
28454393 2017
13
Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta). 61
28185292 2017
14
[Telangiectatic osteosarcoma in an infant]. 61
29364816 2017
15
Current management of aneurysmal bone cysts. 61
27778155 2016
16
Central Telangiectatic Osteosarcoma of the Mandible in a Paediatric Patient: A Rarity. 61
28208989 2016
17
Telangiectatic osteosarcoma of the rib: a rare entity and a potential diagnostic pitfall. 61
28195259 2016
18
Telangiectatic osteosarcoma: a review of 87 cases. 61
27469493 2016
19
Aneurysmal Bone Cyst: An Analysis of 38 Cases and Report of Four Unusual Surface Ones. 61
27200397 2016
20
Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma. 61
26457357 2015
21
Differential diagnostic value of "blue reticulated chondroid-like material" in aneurysmal bone cysts: a classic histopathologic analysis of 215 cases. 61
25972324 2015
22
FROM ANEURYSMAL BONE CYST TO TELANGIECTATIC OSTEOSARCOMA WITH METASTASIS IN INGUINAL LYMPH NODES - CASE REPORT. 61
26214993 2015
23
Telangiectatic osteosarcoma affecting the mandible. 61
25364166 2014
24
[Secondary telangiectatic osteosarcoma of the left femur. A case presentation of an unusual course of disease]. 61
24737216 2014
25
Preoperative easily misdiagnosed telangiectatic osteosarcoma: clinical-radiologic-pathologic correlations. 61
24334494 2013
26
Pathology in practice. Telangiectatic osteosarcoma. 61
23634678 2013
27
Telangiectatic osteosarcoma. 61
23629998 2013
28
Telangiectatic osteosarcoma: a review of literature. 61
23745051 2013
29
[Telangiectatic osteosarcoma secondary to a liposclerosing myxofibrous tumor: a case report]. 61
23010399 2012
30
Aggressive aneurysmal bone cyst of the maxilla confused with telangiectatic osteosarcoma. 61
21862268 2012
31
Telangiectatic osteosarcoma. 61
22540307 2012
32
Primary telangiectatic osteosarcoma of the cervical spine. 61
22225487 2012
33
Aneurysmal bone cyst. 61
22474093 2012
34
Telangiectatic osteosarcoma: Pathological rarity and scintigraphic exclusivity. 61
23599606 2012
35
The immunophenotype of osteoclasts and macrophage polykaryons. 61
21561891 2011
36
The significance of MGMT protein detection in evaluation of osteosarcoma necrosis rate after cisplatin chemotherapy. 61
21619552 2011
37
Primary telangiectatic osteosarcoma of occipital bone: a case report and review of literature. 61
21339678 2011
38
Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. 61
19826810 2010
39
Metastatic potential of an aneurysmal bone cyst. 61
19838726 2009
40
Plain X-ray, computed tomography and magnetic resonance imaging findings of telangiectatic osteosarcoma: a case report. 61
19918488 2009
41
Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. 61
19271217 2009
42
Right ventricular rupture after lateral thoracotomy for removal of rib-associated telangiectatic osteosarcoma in a dog. 61
19691514 2009
43
Telangiectatic osteosarcoma: radiologic and pathologic findings. 61
19325054 2009
44
Pediatric and adult osteosarcoma: comparisons and contrasts in presentation and therapy. 61
20213401 2009
45
A case of an aneurysmal bone cyst of a metatarsal: review of the differential diagnosis and treatment options. 61
19110164 2009
46
Telangiectatic osteosarcoma of the spine: a case report. 61
18421481 2008
47
Telangiectatic osteosarcoma of the patella. 61
19292411 2008
48
Epidemiologic study of 112 osteosarcomas in Chiang Mai University Hospital, Thailand. 61
17710983 2007
49
Telangiectatic osteosarcoma: the St. Jude Children's Research Hospital's experience. 61
17351949 2007
50
Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. 61
16612549 2006

Variations for Telangiectatic Osteogenic Sarcoma

Expression for Telangiectatic Osteogenic Sarcoma

Search GEO for disease gene expression data for Telangiectatic Osteogenic Sarcoma.

Pathways for Telangiectatic Osteogenic Sarcoma

GO Terms for Telangiectatic Osteogenic Sarcoma

Biological processes related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin-dependent protein catabolic process GO:0006511 8.8 USP6 MDM2 COPS3

Sources for Telangiectatic Osteogenic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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