Telangiectatic Osteogenic Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Telangiectatic Osteogenic Sarcoma

MalaCards integrated aliases for Telangiectatic Osteogenic Sarcoma:

Name: Telangiectatic Osteogenic Sarcoma ¹² ¹⁵

Telangiectatic Osteosarcoma ¹² ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6951

NCIt ⁵⁰ C3902

SNOMED-CT ⁶⁸ 78453009

UMLS ⁷³ C0259782

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Summaries for Telangiectatic Osteogenic Sarcoma

MalaCards based summary : Telangiectatic Osteogenic Sarcoma, also known as telangiectatic osteosarcoma, is related to osteogenic sarcoma and sarcoma, and has symptoms including pain An important gene associated with Telangiectatic Osteogenic Sarcoma is CYP4V2 (Cytochrome P450 Family 4 Subfamily V Member 2). The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include bone.

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Related Diseases for Telangiectatic Osteogenic Sarcoma

Diseases related to Telangiectatic Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	osteogenic sarcoma	10.5
2	sarcoma	10.5
3	retinoblastoma	9.9
4	aneurysmal bone cysts	9.9

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Symptoms & Phenotypes for Telangiectatic Osteogenic Sarcoma

UMLS symptoms related to Telangiectatic Osteogenic Sarcoma:

pain

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Drugs & Therapeutics for Telangiectatic Osteogenic Sarcoma

Drugs for Telangiectatic Osteogenic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cyproheptadine

Approved

Phase 3

129-03-3

2913

Synonyms:

129-03-3

1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine

1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine

1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine

1-Methyl-4-(5H-dibenzo(a,D)cycloheptenylidene)piperidine

4-(5-dibenzo(a,D)Cyclohepten-5-ylidine)-1-methylpiperidine

4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine

4-(5-Dibenzo(a,D)cyclohepten-5-ylidine)-1-methylpiperidine

4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene

4-(5H-dibenzo(a,D)Cyclohepten-5-ylidene)-1-methylpiperidine

4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine

4-(5H-Dibenzo(a,D)cyclohepten-5-ylidene)-1-methylpiperidine

4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine

4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine

41354-29-4

4-dibenzo[a,D]Cyclohepten-5-ylidene-1-methyl-piperidine

4-Dibenzo[a,D]cyclohepten-5-ylidene-1-methyl-piperidine

5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene

5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene

5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,D)cyclopheptene

5-20-08-00500 (Beilstein Handbook Reference)

AC1L1ER8

AKOS004119847

Antergan

Axoprol

BIDD:GT0324

Biomol-NT_000131

BPBio1_000096

BPBio1_000155

BRD-K28143534-001-01-4

BRD-K28143534-003-03-6

BRN 1685976

BSPBio_000086

C06935

CAS-969-33-5

CCRIS 5232

CHEBI:4046

CHEMBL516

CID2913

Ciproheptadina

Ciproheptadina [INN-Spanish]

Ciprovit

Ciprovit (TN)

Cypoheptadine

Cyproheptadiene

Cyproheptadin

Cyproheptadine

CYPROHEPTADINE

Cyproheptadine (INN)

Cyproheptadine [INN:BAN]

Cyproheptadine Hcl

Cyproheptadinum

Cyproheptadinum [INN-Latin]

D07765

DB00434

Dibenzosuberonone/Cyproheptadine

Dihexazin

Dronactin

EINECS 204-928-9

Eiproheptadine

Glutodina

HMS2090P20

HSDB 3048

L001016

Lopac0_000246

Lopac-C-6022

LS-114933

MK 141

MolPort-002-507-777

NCGC00015252-01

NCGC00015252-02

NCGC00015252-03

NCGC00015252-09

NCGC00024293-02

NCGC00024293-04

NCGC00024293-05

nchembio.559-comp10

Oprea1_498140

PDSP1_001229

PDSP2_001213

Periactin

Periactine

Periactinol

Peritol

Prestwick0_000103

Prestwick1_000103

Prestwick2_000103

Prestwick3_000103

SPBio_002025

STK802098

Tocris-0996

UNII-2YHB6175DO

Viternum

2

Histamine

Approved, Investigational

Phase 3

75614-87-8, 51-45-6

774

Synonyms:

.beta.-Imidazolyl-4-ethylamine

[3H]histamine

1avn

1H-Imidazole-4-ethanamine

1H-Imidazole-5-ethanamine

1qft

2-(1H-imidazol-4-yl)ethan-1-amine

2-(1H-Imidazol-4-yl)ethanamine

2-(1H-Imidazol-4-yl)ethylamine

2-(1H-imidazol-5-yl)ethanamine

2-(1H-Imidazol-5-yl)ethanamine

2-(1H-Imidazol-5-yl)ethylamine

2-(3H-Imidazol-4-yl)-ethylamine

2-(4-Imidazolyl)ethanamine

2-(4-imidazolyl)ethylamine

2-(4-Imidazolyl)ethylamine

2-[4-Imidazolyl]ethylamine

2-Imidazol-4-ylethylamine

2-Imidazol-4-yl-ethylamine

4-(2-Aminoethyl)-1H-imidazole

4-(2-Aminoethyl)imidazole

4-imidazoleethylamine

4-Imidazoleethylamine

51-45-6

53290_FLUKA

5-imidazoleethylamine

5-Imidazoleethylamine

64422-25-9

924364-91-0

AC-13185

AC1L19ZT

AC1Q54BV

AC1Q54BW

AKOS000274386

ALBB-005968

BCBcMAP01_000250

beta-aminoethylglyoxaline

beta-Aminoethylglyoxaline

beta-aminoethylimidazole

beta-Aminoethylimidazole

beta-aminothethylglyoxaline

beta-Aminothethylglyoxaline

beta-Imidazolyl-4-ethylamine

b-Imidazolyl-4-ethylamine

Bio1_000487

Bio1_000976

Bio1_001465

Bio2_000389

Bio2_000869

bmse000744

BSPBio_001117

BSPBio_002124

C00388

CCRIS 6535

Ceplene

CHEBI:18295

CHEMBL90

CID774

D08040

Dihydrochloride, histamine

DivK1c_000308

EINECS 200-100-6

Eramin

Ergamine

Ergotidine

F411C768-A159-4FC0-A195-291A08BB03AA

Free histamine

H7125_SIGMA

histamine

Histamine (DCF)

Histamine [USAN]

Histamine Base

Histamine dihydrochloride

Histamine hydrochloride

Histamine, Free Base

Histaminum

Histaminum (TN)

HMS1362G19

HMS1792G19

HMS1990G19

HSDB 3338

HSM

Hydrochloride, histamine

IDI1_000308

IDI1_002144

Imidazole-4-ethylamine

Istamina

Istamina [Italian]

KBio1_000308

KBio2_000457

KBio2_001325

KBio2_003025

KBio2_003893

KBio2_005593

KBio2_006461

KBio3_000853

KBio3_000854

KBio3_001344

KBioGR_000457

KBioGR_001580

KBioSS_000457

KBioSS_001325

L000292

L-Histamin base

L-histamine

L-Histamine

Lopac0_000595

Lopac-H-7250

LS-75835

MLS000069447

MolPort-001-785-597

MolPort-002-042-264

NCGC00015513-01

NCGC00015513-08

NCGC00093371-02

NCGC00093371-03

NCGC00093371-04

NCGC00093371-05

nchembio.87-comp54

nchembio714-comp1

NINDS_000308

NSC 33792

NSC33792

Peremin

SDCCGMLS-0066601.P001

SMP1_000151

SMR000059091

SPBio_000729

Spectrum_000845

Spectrum2_000665

Spectrum3_000452

Spectrum4_000960

Spectrum5_000796

ST073926

STK346752

STOCK5S-55669

Theramine

UNII-820484N8I3

WLN: T5M CNJ D2Z

ZERO/004089

3

Histamine Phosphate

Phase 3

51-74-1

65513

Synonyms:

1H-Imidazole-4-ethanamine, phosphate (1:2)

2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)

4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)

4-(2-Aminoethyl)imidazole di-acid phosphate

4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate

51-74-1

53623-99-7

74-56-6

AC1L23E4

CID65513

D04445

DB00667

EINECS 200-118-4

H0147

Histamine acid phosphate

Histamine biphosphate

Histamine dihydrogen phosphate

Histamine diphosphate

Histamine phosphate (1:2)

Histamine phosphate (TN)

Histamine phosphate (USP)

Histamine phosphate [USP]

Histamine positive

LS-78569

UNII-QWB37T4WZZ

4

Serotonin Agents

Phase 3

5

Serotonin Antagonists

Phase 3

6

Gastrointestinal Agents

Phase 3

7

Neurotransmitter Agents

Phase 3

8

Histamine Antagonists

Phase 3

9

Histamine H1 Antagonists

Phase 3

10

Dermatologic Agents

Phase 3

11

Anti-Allergic Agents

Phase 3

12

Antipruritics

Phase 3

13

Serotonin

Investigational, Nutraceutical

Phase 3

50-67-9

5202

Synonyms:

3-(2-Aminoethyl)-1H-indol-5-ol

3-(2-Aminoethyl)indol-5-ol

3-(b-Aminoethyl)-5-hydroxyindole

5 Hydroxytryptamine

5-HT

5-HTA

5-Hydroxy-3-(b-aminoethyl)indole

5-Hydroxyltryptamine

5-Hydroxytriptamine

5-Hydroxytryptamine

5-Hydroxy-tryptamine

Antemovis

DS Substance

Enteramin

Enteramine

Hippophaine

Hydroxytryptamine

Serotonine

sérotonine

thrombocytin

Thrombocytin

thrombotonin

Thrombotonin

14

Sunitinib

Approved, Investigational

Phase 2

341031-54-7, 557795-19-4

5329102

Synonyms:

(2S)-2-hydroxybutanedioic acid

1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)

326914-13-0

341031-54-7

5-(5-FLUORO-2-OXO-1,2-DIHYDRO-INDOL-3-YLIDENEMETHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID (2-DIETHYLAMINO-ETHYL)-AMIDE

5-(5-fluoro-2-oxo-1,2-Dihydroindolylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide

557795-19-4

AC1NS62J

AC1O5CMQ

AKOS005145765

Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)

CHEBI:38940

CHEBI:550864

CHEMBL1567

CHEMBL535

CID5329102

CID6456015

D06402

D08552

DB01268

DB07417

EN002687

FT-0083555

FT-0083556

I01-1229

K00588a

KS-5022

LS-186078

LS-187023

LS-187648

MolPort-003-986-763

N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate

N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

NCGC00164631-01

NSC736511

NSC750690

PDGF TK antagonist

PHA-290940AD

PNU-290940AD

S1042_Selleck

ST51053712

SU 011248

SU 11248

SU010398

SU-010398

Su-011248

SU011248

SU011248 L-malate salt

SU-011248 L-malate salt

SU11248

SU-11248

SU-11248 L-malate salt

SU-11248J

SU-12662

Sunitanib

sunitinib

Sunitinib

Sunitinib (free base)

Sunitinib (INN)

Sunitinib malate

Sunitinib malate (JAN/USAN)

Sunitinib malate [USAN]

sunitinibum

Sunitinibum

Sutent

Sutent (TN)

Sutent, SU-11248

TL8002546

UNII-LVX8N1UT73

UNII-V99T50803M

15

Angiogenesis Inhibitors

Phase 2

16

Angiogenesis Modulating Agents

Phase 2

17

Immunosuppressive Agents

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer	Terminated	NCT01132547	Phase 3	cyproheptadine hydrochloride
2	Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas	Completed	NCT00474994	Phase 2	sunitinib malate

Search NIH Clinical Center for Telangiectatic Osteogenic Sarcoma

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Genetic Tests for Telangiectatic Osteogenic Sarcoma

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Anatomical Context for Telangiectatic Osteogenic Sarcoma

MalaCards organs/tissues related to Telangiectatic Osteogenic Sarcoma:

⁴¹

Bone

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Publications for Telangiectatic Osteogenic Sarcoma

Articles related to Telangiectatic Osteogenic Sarcoma:

#	Title	Authors	Year
1	Telangiectatic osteogenic sarcoma: an unusual presentation. ( 1400148 )	Simoens C.J....Tanghe W.F.	1992
2	Telangiectatic osteogenic sarcoma of the extremities. Results in 17 patients treated with neoadjuvant chemotherapy. ( 1884565 )	Pignatti G....Capanna R.	1991
3	Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for telangiectatic osteogenic sarcoma of the extremities. ( 2477510 )	Bacci G....Campanacci M.	1989
4	Telangiectatic osteogenic sarcoma. Improved survival with combination chemotherapy. ( 2424660 )	Rosen G....Nirenberg A.	1986
5	Telangiectatic osteogenic sarcoma: a clinicopathologic study of 124 patients. ( 6950802 )	Huvos A.G....Butler A.	1982
6	Telangiectatic osteogenic sarcoma. ( 1069603 )	Matsuno T....DAHLIN D.C.	1976
7	Telangiectatic osteogenic sarcoma. A review of twenty-eight cases. ( 4529332 )	Farr G.H....Foote F.W.	1974

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Genes for Telangiectatic Osteogenic Sarcoma

Genes related to Telangiectatic Osteogenic Sarcoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CYP4V2	Cytochrome P450 Family 4 Subfamily V Member 2	Protein Coding	17.28	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	CYCS	Cytochrome C, Somatic	Protein Coding	14.45	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Telangiectatic Osteogenic Sarcoma

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Expression for Telangiectatic Osteogenic Sarcoma

Search GEO for disease gene expression data for Telangiectatic Osteogenic Sarcoma.

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Pathways for Telangiectatic Osteogenic Sarcoma

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GO Terms for Telangiectatic Osteogenic Sarcoma

Biological processes related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	8.62	CYCS CYP4V2

Molecular functions related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:0020037	8.62	CYCS CYP4V2

Sources

Sources for Telangiectatic Osteogenic Sarcoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia