MCID: TLN002
MIFTS: 45

Telangiectatic Osteogenic Sarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Telangiectatic Osteogenic Sarcoma

MalaCards integrated aliases for Telangiectatic Osteogenic Sarcoma:

Name: Telangiectatic Osteogenic Sarcoma 12 15
Telangiectatic Osteosarcoma 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:6951
NCIt 51 C3902
SNOMED-CT 69 78453009
UMLS 74 C0259782

Summaries for Telangiectatic Osteogenic Sarcoma

MalaCards based summary : Telangiectatic Osteogenic Sarcoma, also known as telangiectatic osteosarcoma, is related to osteogenic sarcoma and sarcoma, and has symptoms including pain An important gene associated with Telangiectatic Osteogenic Sarcoma is MAP7D3 (MAP7 Domain Containing 3), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include bone, lymph node and spinal cord, and related phenotypes are Increased cell death HMECs cells and cellular

Related Diseases for Telangiectatic Osteogenic Sarcoma

Diseases related to Telangiectatic Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 osteogenic sarcoma 10.6
2 sarcoma 10.6
3 aneurysmal bone cysts 10.4
4 conventional central osteosarcoma 10.3 BGLAP MAP7D3 MDM2
5 bone osteosarcoma 10.3 BGLAP MAP7D3 MDM2
6 interval angle-closure glaucoma 10.3 IDH1 IDH2
7 adult oligodendroglioma 10.3 IDH1 IDH2
8 fainting 10.3 F8 VWF
9 enchondroma 10.3 IDH1 IDH2
10 cerebral arteritis 10.3 F8 VWF
11 ring chromosome 7 10.3 MDM2 TP53
12 zika virus infection 10.3 MDM2 TP53
13 ischemic fasciitis 10.2 CDKN2A MDM2 USP6
14 chondroblastic osteosarcoma 10.2 BGLAP IDH1 IDH2
15 hemarthrosis 10.2 BGLAP F8 VWF
16 localized osteosarcoma 10.2 CDKN2A CYP4V2
17 histiocytic sarcoma 10.2 CD163 CDKN2A
18 infiltrating angiolipoma 10.2 CDKN2A MDM2 VWF
19 chondrosarcoma 10.2
20 angiosarcoma 10.2
21 juxtacortical osteosarcoma 10.2
22 histiocytoma 10.2 CD163 MDM2 TP53
23 cerebellar astrocytoma 10.1 IDH1 TP53
24 myxosarcoma 10.1 MDM2 TP53 VWF
25 protoplasmic astrocytoma 10.1 IDH2 TP53
26 intracranial chondrosarcoma 10.1 IDH1 IDH2 TP53
27 gliomatosis cerebri 10.1 IDH1 MDM2 TP53
28 actinic cheilitis 10.1 MDM2 TP53
29 lymphangiosarcoma 10.1 F8 MYC VWF
30 fibrosarcoma of bone 10.1 CDKN2A MDM2 MYC
31 dedifferentiated liposarcoma 10.1 CDKN2A MDM2 TP53
32 liposarcoma 10.1 CDKN2A MDM2 TP53
33 adult medulloblastoma 10.1 IDH1 MDM2 TP53
34 verrucous carcinoma 10.1 CDKN2A MDM2 TP53
35 giant cell glioblastoma 10.1 IDH1 MDM2 TP53
36 bile duct adenocarcinoma 10.1 IDH1 IDH2 TP53
37 cellular schwannoma 10.1 CDKN2A MDM2 TP53
38 peripheral osteosarcoma 10.1 FOS IDH1 MDM2
39 drug-induced mental disorder 10.1 FOS IDH1 IDH2
40 drug psychosis 10.1 FOS IDH1 IDH2
41 bone giant cell sarcoma 10.0 H3F3A H3F3B TP53
42 malignant giant cell tumor 10.0 H3F3A H3F3B TP53
43 brain stem cancer 10.0 H3F3A H3F3B TP53
44 skin melanoma 10.0 CDKN2A MDM2 TP53
45 periosteal chondrosarcoma 10.0 CDKN2A IDH1 IDH2 MDM2
46 adenocarcinoma 10.0
47 thoracic outlet syndrome 10.0
48 megaesophagus 10.0 CDKN2A MYC TP53
49 intrahepatic cholangiocarcinoma 10.0 IDH1 IDH2 TP53
50 suppressor of tumorigenicity 3 10.0 CDKN2A MYC TP53

Graphical network of the top 20 diseases related to Telangiectatic Osteogenic Sarcoma:



Diseases related to Telangiectatic Osteogenic Sarcoma

Symptoms & Phenotypes for Telangiectatic Osteogenic Sarcoma

UMLS symptoms related to Telangiectatic Osteogenic Sarcoma:


pain

GenomeRNAi Phenotypes related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.17 ATRX F8 ITGAV JUN MDM2 MYC

MGI Mouse Phenotypes related to Telangiectatic Osteogenic Sarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 ATRX CD163 CDKN2A CYCS FOS H3F3B
2 cardiovascular system MP:0005385 10.17 ATRX CD163 CDKN2A CYCS IDH2 ITGAV
3 hematopoietic system MP:0005397 10.1 CD163 CDKN2A CYCS F8 FOS IDH1
4 embryo MP:0005380 10.07 ATRX CDKN2A CYCS FOS H3F3B ITGAV
5 homeostasis/metabolism MP:0005376 10.03 CD163 CDKN2A CYP4V2 F8 FOS IDH1
6 immune system MP:0005387 9.93 CD163 CDKN2A CYCS F8 FOS IDH1
7 mortality/aging MP:0010768 9.77 ATRX CDKN2A CYCS F8 FOS H3F3B
8 neoplasm MP:0002006 9.17 CDKN2A FOS IDH2 ITGAV MDM2 MYC

Drugs & Therapeutics for Telangiectatic Osteogenic Sarcoma

Drugs for Telangiectatic Osteogenic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 51-45-6 774
3
Histamine Phosphate Phase 3 51-74-1 65513
4 Anti-Allergic Agents Phase 3
5 Neurotransmitter Agents Phase 3
6 Histamine H1 Antagonists Phase 3
7 Serotonin Agents Phase 3
8 Serotonin Antagonists Phase 3
9 Antipruritics Phase 3
10 Dermatologic Agents Phase 3
11 Gastrointestinal Agents Phase 3
12 Histamine Antagonists Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
15 Immunosuppressive Agents Phase 2
16 Angiogenesis Modulating Agents Phase 2
17 Protein Kinase Inhibitors Phase 2
18 Angiogenesis Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate

Search NIH Clinical Center for Telangiectatic Osteogenic Sarcoma

Genetic Tests for Telangiectatic Osteogenic Sarcoma

Anatomical Context for Telangiectatic Osteogenic Sarcoma

MalaCards organs/tissues related to Telangiectatic Osteogenic Sarcoma:

42
Bone, Lymph Node, Spinal Cord

Publications for Telangiectatic Osteogenic Sarcoma

Articles related to Telangiectatic Osteogenic Sarcoma:

(show top 50) (show all 62)
# Title Authors Year
1
Telangiectatic osteosarcoma and renal adenocarcinoma in an Oscar (Astronotus ocellatus, Agassiz): Diagnostic imaging and immunohistochemical study. ( 29572933 )
2018
2
Identification of probable telangiectatic osteosarcoma from a dog skull from multicultural settlement Polwica-Skrzypnik in Lower Silesia, Poland. ( 30139695 )
2018
3
Primary appendicular hemangiosarcoma and telangiectatic osteosarcoma in 70 dogs: A Veterinary Society of Surgical Oncology retrospective study. ( 30051473 )
2018
4
Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst. ( 29892520 )
2018
5
Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta). ( 28185292 )
2017
6
Use of routine histopathology and factor VIII-related antigen/von Willebrand factor immunohistochemistry to differentiate primary hemangiosarcoma of bone from telangiectatic osteosarcoma in 54 dogs. ( 27507032 )
2017
7
Telangiectatic osteosarcoma of the rib: a rare entity and a potential diagnostic pitfall. ( 28195259 )
2016
8
Central Telangiectatic Osteosarcoma of the Mandible in a Paediatric Patient: A Rarity. ( 28208989 )
2016
9
Telangiectatic osteosarcoma: a review of 87 cases. ( 27469493 )
2016
10
FROM ANEURYSMAL BONE CYST TO TELANGIECTATIC OSTEOSARCOMA WITH METASTASIS IN INGUINAL LYMPH NODES - CASE REPORT. ( 26214993 )
2015
11
Preoperative easily misdiagnosed telangiectatic osteosarcoma: clinical-radiologic-pathologic correlations. ( 24334494 )
2013
12
Aggressive aneurysmal bone cyst of the maxilla confused with telangiectatic osteosarcoma. ( 21862268 )
2012
13
Primary telangiectatic osteosarcoma of the cervical spine. ( 22225487 )
2012
14
Telangiectatic osteosarcoma. ( 22540307 )
2012
15
Telangiectatic osteosarcoma: Pathological rarity and scintigraphic exclusivity. ( 23599606 )
2012
16
Primary telangiectatic osteosarcoma of occipital bone: a case report and review of literature. ( 21339678 )
2011
17
Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. ( 19826810 )
2010
18
Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. ( 19271217 )
2009
19
Telangiectatic osteosarcoma: radiologic and pathologic findings. ( 19325054 )
2009
20
Plain X-ray, computed tomography and magnetic resonance imaging findings of telangiectatic osteosarcoma: a case report. ( 19918488 )
2009
21
Telangiectatic osteosarcoma of the spine: a case report. ( 18421481 )
2008
22
Telangiectatic osteosarcoma of the patella. ( 19292411 )
2008
23
Dedifferentiated chondrosarcoma with telangiectatic osteosarcoma-like features. ( 17071806 )
2006
24
Complete segmental resection of the spine, including the spinal cord, for telangiectatic osteosarcoma: a report of 2 cases. ( 16481940 )
2006
25
Primary pelvic telangiectatic osteosarcoma metastatic to both orbits. ( 14752317 )
2004
26
Vertebral telangiectatic osteosarcoma in a dog. ( 15334352 )
2004
27
Oral metastasis of telangiectatic osteosarcoma. ( 12657038 )
2003
28
Telangiectatic osteosarcoma of the clavicle: case report. ( 12866244 )
2003
29
Telangiectatic osteosarcoma: a clinicopathologic analysis of 14 cases. ( 12475437 )
2002
30
Multicentric telangiectatic osteosarcoma. ( 11328536 )
2001
31
Telangiectatic osteosarcoma of the extremity: neoadjuvant chemotherapy in 24 cases. ( 11372948 )
2001
32
Dedifferentiated chondrosarcoma with features of telangiectatic osteosarcoma. ( 10643020 )
1999
33
Post-Paget telangiectatic osteosarcoma of the skull. ( 10486018 )
1999
34
Telangiectatic osteosarcoma of the skull base. ( 9576668 )
1998
35
Local recurrence of a phyllodes tumour of the breast presenting with widespread differentiation to a telangiectatic osteosarcoma. ( 9930079 )
1998
36
Telangiectatic osteosarcoma of the skull. A post-Paget case. ( 9266145 )
1997
37
An unusual presentation of telangiectatic osteosarcoma. ( 8727089 )
1996
38
Primary chemotherapy and delayed surgery for non-metastatic telangiectatic osteosarcoma of the extremities. Results in 28 patients. ( 8080676 )
1994
39
Familial occurrence of telangiectatic osteosarcoma: cousin cases. ( 8113361 )
1994
40
Extraskeletal telangiectatic osteosarcoma. ( 8490830 )
1993
41
Telangiectatic osteogenic sarcoma: an unusual presentation. ( 1400148 )
1992
42
Telangiectatic osteogenic sarcoma of the extremities. Results in 17 patients treated with neoadjuvant chemotherapy. ( 1884565 )
1991
43
Telangiectatic osteosarcoma. ( 1884532 )
1991
44
Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for telangiectatic osteogenic sarcoma of the extremities. ( 2477510 )
1989
45
Telangiectatic osteosarcoma--a case report. ( 2597366 )
1989
46
Effectiveness of chemotherapy in the management of metastatic telangiectatic osteosarcoma. ( 3162788 )
1988
47
High alkaline phosphatase activity of telangiectatic osteosarcoma (TOS) and its diagnostic significance. ( 3474863 )
1987
48
The radiological appearances of telangiectatic osteosarcoma. A study of 14 cases. ( 3473690 )
1987
49
Telangiectatic osteogenic sarcoma. Improved survival with combination chemotherapy. ( 2424660 )
1986
50
Telangiectatic osteosarcoma: unusual behaviour. ( 3455674 )
1986

Variations for Telangiectatic Osteogenic Sarcoma

Expression for Telangiectatic Osteogenic Sarcoma

Search GEO for disease gene expression data for Telangiectatic Osteogenic Sarcoma.

Pathways for Telangiectatic Osteogenic Sarcoma

Pathways related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 CDKN2A CYCS FOS H3F3A H3F3B ITGAV
2
Show member pathways
13.89 CDKN2A CYCS FOS H3F3A H3F3B ITGAV
3
Show member pathways
13.09 CDKN2A CYCS FOS H3F3A H3F3B JUN
4
Show member pathways
12.98 CDKN2A CYCS FOS JUN MDM2 TP53
5
Show member pathways
12.85 CDKN2A CYCS FOS ITGAV JUN MDM2
6
Show member pathways
12.81 CDKN2A CYCS FOS JUN MDM2 MYC
7
Show member pathways
12.78 CDKN2A FOS JUN MYC TP53
8
Show member pathways
12.72 CDKN2A CYCS FOS JUN MDM2 MYC
9
Show member pathways
12.71 CDKN2A FOS JUN MDM2 TP53
10 12.65 CDKN2A CYCS FOS ITGAV JUN MDM2
11
Show member pathways
12.59 FOS JUN MDM2 MYC TP53
12
Show member pathways
12.46 ITGAV JUN MDM2 TP53
13 12.44 FOS JUN MYC TP53
14
Show member pathways
12.41 FOS MDM2 MYC TP53
15 12.38 CDKN2A MDM2 MYC TP53
16
Show member pathways
12.37 CDKN2A CYCS MDM2 MYC TP53
17 12.35 CDKN2A FOS JUN MYC TP53
18 12.31 ITGAV MDM2 MYC TP53
19 12.31 CDKN2A JUN MDM2 TP53
20
Show member pathways
12.24 CDKN2A FOS JUN MYC
21
Show member pathways
12.23 ITGAV MDM2 MYC TP53
22 12.23 H3F3A H3F3B MDM2 MYC TP53
23 12.18 CDKN2A MDM2 MYC TP53
24 12.15 ITGAV MDM2 MYC TP53
25 12.15 JUN MDM2 MYC TP53
26
Show member pathways
12.14 CYCS JUN MYC TP53
27 12.09 FOS ITGAV JUN TP53
28 12.07 FOS JUN MYC TP53
29
Show member pathways
12.04 FOS ITGAV JUN TP53
30 12.04 CDKN2A FOS JUN MDM2 TP53
31 11.99 ITGAV MDM2 MYC TP53
32 11.97 CDKN2A MDM2 MYC TP53
33 11.94 CDKN2A JUN MDM2 TP53
34 11.89 CDKN2A JUN MDM2 MYC TP53
35 11.87 CYCS ITGAV MYC TP53
36 11.86 MDM2 MYC TP53
37
Show member pathways
11.85 JUN MDM2 TP53
38 11.79 FOS JUN MYC
39
Show member pathways
11.76 CDKN2A MDM2 TP53
40 11.75 CDKN2A MDM2 MYC TP53
41 11.74 CDKN2A CYCS MDM2 TP53
42 11.72 FOS JUN MYC
43 11.71 ATRX MYC TP53
44 11.71 FOS JUN MYC
45 11.7 IDH1 MYC TP53
46 11.68 CDKN2A FOS JUN MDM2 TP53
47 11.68 BGLAP FOS JUN MDM2 TP53
48 11.62 BGLAP JUN MDM2
49 11.6 JUN MDM2 TP53
50
Show member pathways
11.6 JUN MDM2 TP53

GO Terms for Telangiectatic Osteogenic Sarcoma

Cellular components related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor AP-1 complex GO:0035976 8.96 FOS JUN
2 nuclear chromosome GO:0000228 8.92 ATRX H3F3A H3F3B JUN

Biological processes related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 protein deubiquitination GO:0016579 9.85 MDM2 MYC TP53 USP6
2 response to drug GO:0042493 9.77 BGLAP FOS JUN MDM2 MYC
3 blood coagulation GO:0007596 9.73 F8 H3F3A H3F3B VWF
4 Ras protein signal transduction GO:0007265 9.65 CDKN2A JUN TP53
5 response to mechanical stimulus GO:0009612 9.63 BGLAP FOS JUN
6 response to organic cyclic compound GO:0014070 9.62 BGLAP FOS IDH1 JUN
7 replicative senescence GO:0090399 9.56 CDKN2A TP53
8 amyloid fibril formation GO:1990000 9.52 CDKN2A MDM2
9 NADP metabolic process GO:0006739 9.51 IDH1 IDH2
10 response to gravity GO:0009629 9.49 BGLAP FOS
11 isocitrate metabolic process GO:0006102 9.4 IDH1 IDH2
12 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.33 FOS JUN TP53
13 cellular response to actinomycin D GO:0072717 9.26 MDM2 TP53
14 multicellular organism growth GO:0035264 9.24 ATRX
15 DNA replication-independent nucleosome assembly GO:0006336 9.13 ATRX H3F3A H3F3B
16 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.8 CDKN2A FOS JUN MYC TP53
2 protein heterodimerization activity GO:0046982 9.72 FOS H3F3A H3F3B JUN TP53
3 disordered domain specific binding GO:0097718 9.54 CDKN2A MDM2 TP53
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.26 IDH1 IDH2
5 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.26 H3F3A H3F3B JUN TP53
6 isocitrate dehydrogenase activity GO:0004448 9.16 IDH1 IDH2
7 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.8 FOS H3F3A H3F3B

Sources for Telangiectatic Osteogenic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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