MCID: TLN002
MIFTS: 31

Telangiectatic Osteogenic Sarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Telangiectatic Osteogenic Sarcoma

MalaCards integrated aliases for Telangiectatic Osteogenic Sarcoma:

Name: Telangiectatic Osteogenic Sarcoma 12 15
Telangiectatic Osteosarcoma 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6951
NCIt 50 C3902
SNOMED-CT 67 78453009
UMLS 71 C0259782

Summaries for Telangiectatic Osteogenic Sarcoma

MalaCards based summary : Telangiectatic Osteogenic Sarcoma, also known as telangiectatic osteosarcoma, is related to osteogenic sarcoma and aneurysmal bone cysts, and has symptoms including pain An important gene associated with Telangiectatic Osteogenic Sarcoma is USP6 (Ubiquitin Specific Peptidase 6), and among its related pathways/superpathways are Shigellosis and Transcriptional misregulation in cancer. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and ovary.

Related Diseases for Telangiectatic Osteogenic Sarcoma

Diseases related to Telangiectatic Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 osteogenic sarcoma 30.7 MDM2 LINC00901 COPS3
2 aneurysmal bone cysts 30.5 USP6 CDH11
3 juxtacortical osteosarcoma 30.4 MDM2 COPS3
4 osteoblastoma 30.2 USP6 CDH11
5 bone osteosarcoma 29.3 USP6 PRIM1 MDM2 H3-3B H3-3A COPS3
6 sarcoma 10.3
7 spindle cell sarcoma 10.3
8 adult brain stem glioma 10.2 H3-3B H3-3A
9 brain stem glioma 10.2 H3-3B H3-3A
10 bone giant cell sarcoma 10.2 H3-3B H3-3A
11 malignant giant cell tumor 10.2 H3-3B H3-3A
12 spinal cord astrocytoma 10.2 H3-3B H3-3A
13 adult oligodendroglioma 10.2 H3-3B H3-3A
14 childhood oligodendroglioma 10.2 H3-3B H3-3A
15 peripheral osteosarcoma 10.2 MDM2 COPS3
16 childhood brain stem glioma 10.2 H3-3B H3-3A
17 myositis ossificans 10.2 USP6 MDM2
18 childhood pilocytic astrocytoma 10.2 H3-3B H3-3A
19 juvenile pilocytic astrocytoma 10.2 H3-3B H3-3A
20 clear cell chondrosarcoma 10.1 H3-3B H3-3A
21 chondroblastic osteosarcoma 10.1 H3-3B H3-3A
22 proliferative fasciitis 10.1 USP6 CAMTA1
23 colon leiomyoma 10.1 H3-3B H3-3A
24 spinal cord glioma 10.1 H3-3B H3-3A
25 spinal cancer 10.1 H3-3B H3-3A
26 chondrosarcoma 10.1
27 angiosarcoma 10.1
28 brain stem cancer 10.1 H3-3B H3-3A
29 pneumothorax 10.1
30 ossifying fibroma 10.1 USP6 MDM2
31 alpha thalassemia-x-linked intellectual disability syndrome 10.1 H3-3B H3-3A
32 ischemic fasciitis 10.1 USP6 MDM2 CDH11
33 pleomorphic xanthoastrocytoma 10.1 H3-3B H3-3A
34 bone benign neoplasm 10.0 USP6 H3-3B H3-3A
35 bone giant cell tumor 10.0 USP6 H3-3B H3-3A
36 conventional central osteosarcoma 10.0 USP6 MDM2 COPS3
37 chondroblastoma 10.0 USP6 H3-3B H3-3A
38 familial retinoblastoma 10.0 PRIM1 MDM2
39 diffuse astrocytoma 10.0 H3-3B H3-3A
40 benign giant cell tumor 10.0 H3-3B H3-3A
41 adult astrocytic tumour 10.0 MDM2 H3-3B H3-3A
42 diffuse midline glioma, h3 k27m-mutant 10.0 H3-3B H3-3A
43 torticollis 10.0
44 chordoma 10.0
45 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
46 bone disease 10.0
47 fibrous dysplasia 10.0
48 bone cancer 10.0
49 hemangioma 10.0
50 cystic teratoma 10.0

Graphical network of the top 20 diseases related to Telangiectatic Osteogenic Sarcoma:



Diseases related to Telangiectatic Osteogenic Sarcoma

Symptoms & Phenotypes for Telangiectatic Osteogenic Sarcoma

UMLS symptoms related to Telangiectatic Osteogenic Sarcoma:


pain

Drugs & Therapeutics for Telangiectatic Osteogenic Sarcoma

Drugs for Telangiectatic Osteogenic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Neurotransmitter Agents Phase 3
4 Gastrointestinal Agents Phase 3
5 Histamine Antagonists Phase 3
6
Histamine Phosphate Phase 3 51-74-1 65513
7 Anti-Allergic Agents Phase 3
8 Histamine H1 Antagonists Phase 3
9 Dermatologic Agents Phase 3
10
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
11
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
12 Immunosuppressive Agents Phase 2
13 Angiogenesis Inhibitors Phase 2
14 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 A Multicenter Phase II Study of Continuous Dosing of Sunitinib (Sutent®, SU11248) in Non-GIST Sarcomas Completed NCT00474994 Phase 2 sunitinib malate

Search NIH Clinical Center for Telangiectatic Osteogenic Sarcoma

Genetic Tests for Telangiectatic Osteogenic Sarcoma

Anatomical Context for Telangiectatic Osteogenic Sarcoma

MalaCards organs/tissues related to Telangiectatic Osteogenic Sarcoma:

40
Spinal Cord, Ovary

Publications for Telangiectatic Osteogenic Sarcoma

Articles related to Telangiectatic Osteogenic Sarcoma:

(show top 50) (show all 129)
# Title Authors PMID Year
1
Analysis of a Preliminary microRNA Expression Signature in a Human Telangiectatic Osteogenic Sarcoma Cancer Cell Line. 61
33503899 2021
2
Iliac Telangiectatic Osteosarcoma - A Rare Presentation and Diagnostic Pitfall: A Case Report. 61
33403087 2020
3
Aneurysmal bone cyst inadvertently treated with chemotherapy-A series of three cases. 61
32761959 2020
4
The differentiation between aneurysmal bone cyst and telangiectatic osteosarcoma: a clinical, radiographic and MRI study. 61
32248448 2020
5
Primary breast telangiectatic osteosarcoma: a rare entity and a potential diagnostic pitfall. 61
32616343 2020
6
Fluid-fluid levels in musculoskeletal tumor imaging. 61
32767947 2020
7
Evaluation of factors affecting survival rate in primary bone sarcomas with extremity and pelvis involvement. 61
32544060 2020
8
Validation of Fluorescence in situ Hybridization Testing of USP6 Gene Rearrangement for Diagnosis of Primary Aneurysmal Bone Cyst. 61
31611201 2019
9
Identification of probable telangiectatic osteosarcoma from a dog skull from multicultural settlement Polwica-Skrzypnik in Lower Silesia, Poland. 61
30139695 2019
10
Primary appendicular hemangiosarcoma and telangiectatic osteosarcoma in 70 dogs: A Veterinary Society of Surgical Oncology retrospective study. 61
30051473 2018
11
Telangiectatic osteosarcoma and renal adenocarcinoma in an Oscar (Astronotus ocellatus, Agassiz): Diagnostic imaging and immunohistochemical study. 61
29572933 2018
12
Capillary Hemangioma as an Unusual Cause of Doughnut Sign on Bone Scan. 61
29742594 2018
13
Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst. 61
29892520 2018
14
Is Core Needle Biopsy Reliable in Differentiating Between Aggressive Benign and Malignant Radiolucent Bone Tumors? 61
29529643 2018
15
Use of routine histopathology and factor VIII-related antigen/von Willebrand factor immunohistochemistry to differentiate primary hemangiosarcoma of bone from telangiectatic osteosarcoma in 54 dogs. 61
27507032 2017
16
Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta). 61
28185292 2017
17
Prognostic factors and survival rate of osteosarcoma: A single-institution study. 61
25870979 2017
18
Diagnosing and discriminating between primary and secondary aneurysmal bone cysts. 61
28454393 2017
19
[Telangiectatic osteosarcoma in an infant]. 61
29364816 2017
20
Telangiectatic osteosarcoma of the rib: a rare entity and a potential diagnostic pitfall. 61
28195259 2016
21
Central Telangiectatic Osteosarcoma of the Mandible in a Paediatric Patient: A Rarity. 61
28208989 2016
22
Current management of aneurysmal bone cysts. 61
27778155 2016
23
Telangiectatic osteosarcoma: a review of 87 cases. 61
27469493 2016
24
Aneurysmal Bone Cyst: An Analysis of 38 Cases and Report of Four Unusual Surface Ones. 61
27200397 2016
25
Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma. 61
26457357 2015
26
Differential diagnostic value of "blue reticulated chondroid-like material" in aneurysmal bone cysts: a classic histopathologic analysis of 215 cases. 61
25972324 2015
27
FROM ANEURYSMAL BONE CYST TO TELANGIECTATIC OSTEOSARCOMA WITH METASTASIS IN INGUINAL LYMPH NODES - CASE REPORT. 61
26214993 2015
28
Telangiectatic osteosarcoma affecting the mandible. 61
25364166 2014
29
[Secondary telangiectatic osteosarcoma of the left femur. A case presentation of an unusual course of disease]. 61
24737216 2014
30
Preoperative easily misdiagnosed telangiectatic osteosarcoma: clinical-radiologic-pathologic correlations. 61
24334494 2013
31
Pathology in practice. Telangiectatic osteosarcoma. 61
23634678 2013
32
Telangiectatic osteosarcoma. 61
23629998 2013
33
Telangiectatic osteosarcoma: a review of literature. 61
23745051 2013
34
[Telangiectatic osteosarcoma secondary to a liposclerosing myxofibrous tumor: a case report]. 61
23010399 2012
35
Aggressive aneurysmal bone cyst of the maxilla confused with telangiectatic osteosarcoma. 61
21862268 2012
36
Telangiectatic osteosarcoma. 61
22540307 2012
37
Primary telangiectatic osteosarcoma of the cervical spine. 61
22225487 2012
38
Aneurysmal bone cyst. 61
22474093 2012
39
Telangiectatic osteosarcoma: Pathological rarity and scintigraphic exclusivity. 61
23599606 2012
40
The immunophenotype of osteoclasts and macrophage polykaryons. 61
21561891 2011
41
The significance of MGMT protein detection in evaluation of osteosarcoma necrosis rate after cisplatin chemotherapy. 61
21619552 2011
42
Primary telangiectatic osteosarcoma of occipital bone: a case report and review of literature. 61
21339678 2011
43
Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. 61
19826810 2010
44
Metastatic potential of an aneurysmal bone cyst. 61
19838726 2009
45
Plain X-ray, computed tomography and magnetic resonance imaging findings of telangiectatic osteosarcoma: a case report. 61
19918488 2009
46
Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. 61
19271217 2009
47
Right ventricular rupture after lateral thoracotomy for removal of rib-associated telangiectatic osteosarcoma in a dog. 61
19691514 2009
48
Telangiectatic osteosarcoma: radiologic and pathologic findings. 61
19325054 2009
49
Pediatric and adult osteosarcoma: comparisons and contrasts in presentation and therapy. 61
20213401 2009
50
A case of an aneurysmal bone cyst of a metatarsal: review of the differential diagnosis and treatment options. 61
19110164 2009

Variations for Telangiectatic Osteogenic Sarcoma

Expression for Telangiectatic Osteogenic Sarcoma

Search GEO for disease gene expression data for Telangiectatic Osteogenic Sarcoma.

Pathways for Telangiectatic Osteogenic Sarcoma

Pathways related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.72 MDM2 H3-3B H3-3A
2 11.08 MDM2 H3-3B H3-3A
3 10.47 H3-3B H3-3A

GO Terms for Telangiectatic Osteogenic Sarcoma

Cellular components related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.7 THRAP3 PRIM1 MDM2 H3-3B H3-3A CTDSP2
2 nuclear chromosome GO:0000228 8.96 H3-3B H3-3A
3 Barr body GO:0001740 8.62 H3-3B H3-3A

Biological processes related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ubiquitin-dependent protein catabolic process GO:0006511 9.7 USP6 MDM2 COPS3
2 negative regulation of gene expression, epigenetic GO:0045814 9.51 H3-3B H3-3A
3 oogenesis GO:0048477 9.49 H3-3B H3-3A
4 embryo implantation GO:0007566 9.48 H3-3B H3-3A
5 chromatin silencing at rDNA GO:0000183 9.46 H3-3B H3-3A
6 nucleus organization GO:0006997 9.43 H3-3B H3-3A
7 telomere organization GO:0032200 9.4 H3-3B H3-3A
8 DNA replication-independent nucleosome assembly GO:0006336 9.37 H3-3B H3-3A
9 muscle cell differentiation GO:0042692 9.32 H3-3B H3-3A
10 pericentric heterochromatin assembly GO:0031508 9.26 H3-3B H3-3A
11 regulation of centromere complex assembly GO:0090230 9.16 H3-3B H3-3A
12 negative regulation of chromosome condensation GO:1902340 8.96 H3-3B H3-3A
13 telomeric heterochromatin assembly GO:0031509 8.62 H3-3B H3-3A

Molecular functions related to Telangiectatic Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 8.96 H3-3B H3-3A
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.62 H3-3B H3-3A

Sources for Telangiectatic Osteogenic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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