LTL
MCID: TLM001
MIFTS: 17

Telomere Length, Mean Leukocyte (LTL)

Aliases & Classifications for Telomere Length, Mean Leukocyte

MalaCards integrated aliases for Telomere Length, Mean Leukocyte:

Name: Telomere Length, Mean Leukocyte 57 13 6 70
Telm 57
Ltl 57

External Ids:

OMIM® 57 609113
UMLS 70 C1836777

Summaries for Telomere Length, Mean Leukocyte

OMIM® : 57 Telomeres are special functional complexes at the ends of eukaryotic chromosomes involved in maintaining genetic stability and in regulation of cellular life span (2,3:Blackburn, 2000, 2001; Blasco, 2003). Telomere homeostasis is relevant to normal aging and a wide range of disease states. Telomeres are made up of a variable number of tandem repeats (TTTAGGG in humans) that extend over several thousand basepairs. Telomere lengths are characteristic in each human individual and show wide interindividual variability (Slagboom et al., 1994; Jeanclos et al., 2000). (609113) (Updated 20-May-2021)

MalaCards based summary : Telomere Length, Mean Leukocyte, also known as telm, is related to mild cognitive impairment and atherosclerosis susceptibility. An important gene associated with Telomere Length, Mean Leukocyte is TELM (Telomere Length, Mean Leukocyte). Affiliated tissues include liver.

Related Diseases for Telomere Length, Mean Leukocyte

Diseases related to Telomere Length, Mean Leukocyte via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 mild cognitive impairment 10.1
2 atherosclerosis susceptibility 9.9
3 hepatocellular carcinoma 9.9
4 hepatitis 9.9
5 liver cirrhosis 9.9

Graphical network of the top 20 diseases related to Telomere Length, Mean Leukocyte:



Diseases related to Telomere Length, Mean Leukocyte

Symptoms & Phenotypes for Telomere Length, Mean Leukocyte

Clinical features from OMIM®:

609113 (Updated 20-May-2021)

Drugs & Therapeutics for Telomere Length, Mean Leukocyte

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Impact of Personal Telomere Testing on Distress and Health Behaviors: A Randomized Controlled Trial of Women With Short and Average Telomere Lengths Completed NCT04104386
2 Diet Quality Indices and Leukocyte Telomere Length Among Healthy US Adults: Data From the National Health and Nutrition Examination Surveys (NHANES) 1999-2002 Completed NCT03302104

Search NIH Clinical Center for Telomere Length, Mean Leukocyte

Genetic Tests for Telomere Length, Mean Leukocyte

Anatomical Context for Telomere Length, Mean Leukocyte

MalaCards organs/tissues related to Telomere Length, Mean Leukocyte:

40
Liver

Publications for Telomere Length, Mean Leukocyte

Articles related to Telomere Length, Mean Leukocyte:

(show all 36)
# Title Authors PMID Year
1
The heritability of leucocyte telomere length dynamics. 57
25770094 2015
2
Common variants near TERC are associated with mean telomere length. 57
20139977 2010
3
A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length. 57
19359265 2009
4
A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans. 57
18487243 2008
5
Telomere length predicts poststroke mortality, dementia, and cognitive decline. 57
16685698 2006
6
Allele-specific relative telomere lengths are inherited. 57
16440201 2006
7
Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. 57
16400618 2006
8
Telomere length and heredity: Indications of paternal inheritance. 57
16258070 2005
9
Obesity, cigarette smoking, and telomere length in women. 57
16112303 2005
10
Mapping of a major locus that determines telomere length in humans. 57
15520935 2005
11
Mammalian telomeres and telomerase: why they matter for cancer and aging. 57
14582532 2003
12
Switching and signaling at the telomere. 57
11572773 2001
13
Telomere states and cell fates. 57
11081503 2000
14
Telomere length inversely correlates with pulse pressure and is highly familial. 57
10948077 2000
15
Telomere length regulation in mice is linked to a novel chromosome locus. 57
9671732 1998
16
Genetic determination of telomere size in humans: a twin study of three age groups. 57
7977349 1994
17
Transfer Extreme Learning Machine with Output Weight Alignment. 61
33628212 2021
18
Improvement of the Anticancer Activities of Telmisartan by Zn(II) Complexation and Mechanisms of Action. 61
31863274 2020
19
Interaction between Angiotensin Receptor and β-Adrenergic Receptor Regulates the Production of Amyloid β-Protein. 61
32238715 2020
20
Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. 61
33364953 2020
21
An Improved Recognition Approach for Noisy Multispectral Palmprint by Robust L2 Sparse Representation with a Tensor-Based Extreme Learning Machine. 61
30634530 2019
22
Telmisartan Modulates the Oral Mucositis Induced by 5-Fluorouracil in Hamsters. 61
30210365 2018
23
Telmisartan reduces arrhythmias through increasing cardiac connexin43 by inhibiting IL-17 after myocardial infarction in rats. 61
29228446 2017
24
Multispectral image fusion for illumination-invariant palmprint recognition. 61
28558064 2017
25
Revision of Eocene Antarctic carpet sharks (Elasmobranchii, Orectolobiformes) from Seymour Island, Antarctic Peninsula. 61
28785171 2017
26
Ultimate Eocene (Priabonian) Chondrichthyans (Holocephali, Elasmobranchii) of Antarctica. 61
28298806 2016
27
Two Efficient Twin ELM Methods With Prediction Interval. 61
25423657 2015
28
Effect of telmisartan on levels of IL-1, TNF-α, down-regulated COX-2, MMP-2, MMP-9 and RANKL/RANK in an experimental periodontitis model. 61
24118063 2013
29
Validated spectrophotometric methods for the simultaneous determination of telmisartan and atorvastatin in bulk and tablets. 61
23781490 2012
30
Stress degradation studies on Telmisartan and development of a validated method by UV spectrophotometry in bulk and pharmaceutical dosage forms. 61
23781466 2011
31
Telmisartan attenuates isoproterenol-induced cardiac remodeling in rats via regulation of cardiac adiponectin expression. 61
21399654 2011
32
Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice. 61
20585312 2010
33
Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1). 61
17998773 2007
34
The effects of telmisartan and amlodipine on metabolic parameters and blood pressure in type 2 diabetic, hypertensive patients. 61
17318795 2006
35
Application of first-derivative, ratio derivative spectrophotometry, TLC-densitometry and spectrofluorimetry for the simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical dosage forms and plasma. 61
16129437 2005
36
Effects of an angiotensin II antagonist on organ perfusion during the post-resuscitation phase in pigs. 61
11056709 1998

Variations for Telomere Length, Mean Leukocyte

ClinVar genetic disease variations for Telomere Length, Mean Leukocyte:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 DCAF4 NM_015604.4(DCAF4):c.728+1334G>A SNV Uncertain significance 190970 rs2535913 GRCh37: 14:73415233-73415233
GRCh38: 14:72948525-72948525

Expression for Telomere Length, Mean Leukocyte

Search GEO for disease gene expression data for Telomere Length, Mean Leukocyte.

Pathways for Telomere Length, Mean Leukocyte

GO Terms for Telomere Length, Mean Leukocyte

Sources for Telomere Length, Mean Leukocyte

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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