LTL
MCID: TLM001
MIFTS: 17

Telomere Length, Mean Leukocyte (LTL)

Aliases & Classifications for Telomere Length, Mean Leukocyte

MalaCards integrated aliases for Telomere Length, Mean Leukocyte:

Name: Telomere Length, Mean Leukocyte 58 30 13 6 74
Telm 58
Ltl 58

External Ids:

OMIM 58 609113
UMLS 74 C1836777

Summaries for Telomere Length, Mean Leukocyte

OMIM : 58 Telomeres are special functional complexes at the ends of eukaryotic chromosomes involved in maintaining genetic stability and in regulation of cellular life span (3,2:Blackburn, 2000, 2001; Blasco, 2003). Telomere homeostasis is relevant to normal aging and a wide range of disease states. Telomeres are made up of a variable number of tandem repeats (TTTAGGG in humans) that extend over several thousand basepairs. Telomere lengths are characteristic in each human individual and show wide interindividual variability (Slagboom et al., 1994; Jeanclos et al., 2000). (609113)

MalaCards based summary : Telomere Length, Mean Leukocyte, also known as telm, is related to alzheimer disease and hepatocellular carcinoma. An important gene associated with Telomere Length, Mean Leukocyte is TELM (Telomere Length, Mean Leukocyte). The drugs Calcium and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Telomere Length, Mean Leukocyte

Diseases related to Telomere Length, Mean Leukocyte via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 alzheimer disease 10.2
2 hepatocellular carcinoma 10.1
3 hepatitis 10.1
4 liver cirrhosis 10.1
5 benign childhood occipital epilepsy, panayiotopoulos type 10.1

Graphical network of the top 20 diseases related to Telomere Length, Mean Leukocyte:



Diseases related to Telomere Length, Mean Leukocyte

Symptoms & Phenotypes for Telomere Length, Mean Leukocyte

Clinical features from OMIM:

609113

Drugs & Therapeutics for Telomere Length, Mean Leukocyte

Drugs for Telomere Length, Mean Leukocyte (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
3 Antimetabolites Phase 4
4 Hypolipidemic Agents Phase 4
5 Rosuvastatin Calcium Phase 4 147098-20-2
6 Anticholesteremic Agents Phase 4
7 Calcium, Dietary Phase 4
8 Lipid Regulating Agents Phase 4
9
Danazol Approved Phase 1, Phase 2 17230-88-5 28417
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
11 Estrogens Phase 1, Phase 2
12 Hormone Antagonists Phase 1, Phase 2
13 Estrogen Antagonists Phase 1, Phase 2
14 Hormones Phase 1, Phase 2
15 Estrogen Receptor Antagonists Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rosuvastatin Effect on Telomere-telomerase System in ACS Unknown status NCT02299245 Phase 4 rosuvastatin
2 Evaluating Efficacy and Safety of Danazol in Severe Hematologic or Pulmonary Disease Related to Telomeropathy Not yet recruiting NCT03710356 Phase 1, Phase 2 Danazol 200 MG
3 Diet Quality and LTL in NHANES Completed NCT03302104
4 Brain Plasticity and Cellular Aging After Internet-delivered CBT for Social Anxiety Disorder Active, not recruiting NCT02592564 Not Applicable

Search NIH Clinical Center for Telomere Length, Mean Leukocyte

Genetic Tests for Telomere Length, Mean Leukocyte

Genetic tests related to Telomere Length, Mean Leukocyte:

# Genetic test Affiliating Genes
1 Telomere Length, Mean Leukocyte 30

Anatomical Context for Telomere Length, Mean Leukocyte

MalaCards organs/tissues related to Telomere Length, Mean Leukocyte:

42
Brain

Publications for Telomere Length, Mean Leukocyte

Variations for Telomere Length, Mean Leukocyte

ClinVar genetic disease variations for Telomere Length, Mean Leukocyte:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DCAF4 NM_015604.3(DCAF4): c.728+1334G> A single nucleotide variant Uncertain significance rs2535913 GRCh37 Chromosome 14, 73415233: 73415233
2 DCAF4 NM_015604.3(DCAF4): c.728+1334G> A single nucleotide variant Uncertain significance rs2535913 GRCh38 Chromosome 14, 72948525: 72948525

Expression for Telomere Length, Mean Leukocyte

Search GEO for disease gene expression data for Telomere Length, Mean Leukocyte.

Pathways for Telomere Length, Mean Leukocyte

GO Terms for Telomere Length, Mean Leukocyte

Sources for Telomere Length, Mean Leukocyte

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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