LTL
MCID: TLM001
MIFTS: 20

Telomere Length, Mean Leukocyte (LTL)

Aliases & Classifications for Telomere Length, Mean Leukocyte

MalaCards integrated aliases for Telomere Length, Mean Leukocyte:

Name: Telomere Length, Mean Leukocyte 58 13 6 74
Telm 58
Ltl 58

External Ids:

OMIM 58 609113
UMLS 74 C1836777

Summaries for Telomere Length, Mean Leukocyte

OMIM : 58 Telomeres are special functional complexes at the ends of eukaryotic chromosomes involved in maintaining genetic stability and in regulation of cellular life span (2,3:Blackburn, 2000, 2001; Blasco, 2003). Telomere homeostasis is relevant to normal aging and a wide range of disease states. Telomeres are made up of a variable number of tandem repeats (TTTAGGG in humans) that extend over several thousand basepairs. Telomere lengths are characteristic in each human individual and show wide interindividual variability (Slagboom et al., 1994; Jeanclos et al., 2000). (609113)

MalaCards based summary : Telomere Length, Mean Leukocyte, also known as telm, is related to alzheimer disease and hepatocellular carcinoma. An important gene associated with Telomere Length, Mean Leukocyte is TELM (Telomere Length, Mean Leukocyte). The drugs Calcium and Lipid Regulating Agents have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Telomere Length, Mean Leukocyte

Diseases related to Telomere Length, Mean Leukocyte via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 alzheimer disease 10.2
2 hepatocellular carcinoma 10.1
3 hepatitis 10.1
4 liver cirrhosis 10.1

Symptoms & Phenotypes for Telomere Length, Mean Leukocyte

Clinical features from OMIM:

609113

Drugs & Therapeutics for Telomere Length, Mean Leukocyte

Drugs for Telomere Length, Mean Leukocyte (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
2 Lipid Regulating Agents Phase 4
3 Rosuvastatin Calcium Phase 4 147098-20-2
4 Anticholesteremic Agents Phase 4
5 Hypolipidemic Agents Phase 4
6 Antimetabolites Phase 4
7 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
8 Calcium, Dietary Phase 4
9
Danazol Approved Phase 1, Phase 2 17230-88-5 28417
10 Estrogen Receptor Antagonists Phase 1, Phase 2
11 Hormones Phase 1, Phase 2
12 Estrogens Phase 1, Phase 2
13 Hormone Antagonists Phase 1, Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
15 Estrogen Antagonists Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rosuvastatin Effect on Telomere-telomerase System in ACS Unknown status NCT02299245 Phase 4 rosuvastatin
2 Evaluating Efficacy and Safety of Danazol in Severe Hematologic or Pulmonary Disease Related to Telomeropathy Not yet recruiting NCT03710356 Phase 1, Phase 2 Danazol 200 MG
3 Diet Quality and LTL in NHANES Completed NCT03302104
4 Brain Plasticity and Cellular Aging After Internet-delivered CBT for Social Anxiety Disorder Active, not recruiting NCT02592564 Not Applicable

Search NIH Clinical Center for Telomere Length, Mean Leukocyte

Genetic Tests for Telomere Length, Mean Leukocyte

Anatomical Context for Telomere Length, Mean Leukocyte

MalaCards organs/tissues related to Telomere Length, Mean Leukocyte:

42
Brain

Publications for Telomere Length, Mean Leukocyte

Articles related to Telomere Length, Mean Leukocyte:

(show all 20)
# Title Authors Year
1
Identification of abnormal fucosylated-glycans recognized by LTL in saliva of HBV-induced chronic hepatitis, cirrhosis, and hepatocellular carcinoma. ( 30535277 )
2019
2
Changes in pH, colour and the microbiology of black wildebeest (Connochaetes gnou) longissimus thoracis et lumborum (LTL) muscle with normal and high (DFD) muscle pH. ( 30172085 )
2019
3
Formation of copper nanoparticles in LTL nanosized zeolite: spectroscopic characterization. ( 29327021 )
2018
4
A density functional theory study of hydrogen adsorption on Be-, Mg-, and Ca-exchanged LTL zeolite clusters. ( 28488191 )
2017
5
Photoactive Nanomaterials Inspired by Nature: LTL Zeolite Doped with Laser Dyes as Artificial Light Harvesting Systems. ( 28772856 )
2017
6
Effect of Extra-Framework Cations of LTL Nanozeolites to Inhibit Oil Oxidation. ( 26058517 )
2015
7
Linear Temporal Logic (LTL) Based Monitoring of Smart Manufacturing Systems. ( 28730154 )
2015
8
DCAF4, a novel gene associated with leucocyte telomere length. ( 25624462 )
2015
9
Nanozeolite-LTL with Gd(III) deposited in the large and Eu(III) in the small cavities as a magnetic resonance optical imaging probe. ( 24523192 )
2014
10
Decreased leukocyte telomere length (LTL) is associated with stroke but unlikely to be causative. ( 23861874 )
2013
11
Leukocyte telomere length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's disease: a pilot study. ( 22210159 )
2012
12
Can leukocyte telomere length (LTL) be considered as an index in application of neural network in the atherosclerosis risk stratification? ( 19176257 )
2010
13
Investigation of sialylation aberration in N-linked glycopeptides by lectin and tandem labeling (LTL) quantitative proteomics. ( 20923142 )
2010
14
Fine structures of zeolite-Linde-L (LTL): surface structures, growth unit and defects. ( 15372583 )
2004
15
Learning to Learn* (LTL): offering the student academic behaviors that work. ( 9272044 )
1995
16
Learning to Learn (LTL) finds critical placement in a preclinical sequence. ( 9272045 )
1995
17
Infusing Learning to Learn (LTL) in a clinical nursing course. ( 9272046 )
1995
18
Interaction of Lotus-tetragonolobus Lectin (LTL) and an MIF-like factor with guinea-pig macrophages. I. Effects on macrophage migration inhibition and receptor-binding studies. ( 6752005 )
1982
19
Increase in the mass of RNA-containing bodies in the nuclei of slaivary gland cells of lethal larvae of Drosophila melanogaster line ltl (lethal tumorous larvae). ( 4213797 )
1974
20
Observations on ltl (lethal tumorous larvae) of Drosophila melanogaster. ( 5658756 )
1968

Variations for Telomere Length, Mean Leukocyte

ClinVar genetic disease variations for Telomere Length, Mean Leukocyte:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DCAF4 NM_015604.3(DCAF4): c.728+1334G> A single nucleotide variant Uncertain significance rs2535913 GRCh37 Chromosome 14, 73415233: 73415233
2 DCAF4 NM_015604.3(DCAF4): c.728+1334G> A single nucleotide variant Uncertain significance rs2535913 GRCh38 Chromosome 14, 72948525: 72948525

Expression for Telomere Length, Mean Leukocyte

Search GEO for disease gene expression data for Telomere Length, Mean Leukocyte.

Pathways for Telomere Length, Mean Leukocyte

GO Terms for Telomere Length, Mean Leukocyte

Sources for Telomere Length, Mean Leukocyte

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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