LTL
MCID: TLM001
MIFTS: 14

Telomere Length, Mean Leukocyte (LTL)

Aliases & Classifications for Telomere Length, Mean Leukocyte

MalaCards integrated aliases for Telomere Length, Mean Leukocyte:

Name: Telomere Length, Mean Leukocyte 57 29 13 6 73
Telm 57
Ltl 57

External Ids:

OMIM 57 609113
UMLS 73 C1836777

Summaries for Telomere Length, Mean Leukocyte

OMIM : 57 Telomeres are special functional complexes at the ends of eukaryotic chromosomes involved in maintaining genetic stability and in regulation of cellular life span (3,2:Blackburn, 2000, 2001; Blasco, 2003). Telomere homeostasis is relevant to normal aging and a wide range of disease states. Telomeres are made up of a variable number of tandem repeats (TTTAGGG in humans) that extend over several thousand basepairs. Telomere lengths are characteristic in each human individual and show wide interindividual variability (Slagboom et al., 1994; Jeanclos et al., 2000). (609113)

MalaCards based summary : Telomere Length, Mean Leukocyte, also known as telm, is related to alzheimer disease and hepatocellular carcinoma. An important gene associated with Telomere Length, Mean Leukocyte is TELM (Telomere Length, Mean Leukocyte). The drugs Hypolipidemic Agents and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Telomere Length, Mean Leukocyte

Diseases related to Telomere Length, Mean Leukocyte via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 alzheimer disease 10.2
2 hepatocellular carcinoma 10.0
3 hepatitis 10.0
4 liver cirrhosis 10.0

Symptoms & Phenotypes for Telomere Length, Mean Leukocyte

Clinical features from OMIM:

609113

Drugs & Therapeutics for Telomere Length, Mean Leukocyte

Drugs for Telomere Length, Mean Leukocyte (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hypolipidemic Agents Phase 4
2 Calcium, Dietary Phase 4
3 Rosuvastatin Calcium Phase 4 147098-20-2
4 Lipid Regulating Agents Phase 4
5 Anticholesteremic Agents Phase 4
6 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
7 Antimetabolites Phase 4
8
Danazol Approved Phase 1, Phase 2 17230-88-5 28417
9 Estrogen Antagonists Phase 1, Phase 2
10 Estrogens Phase 1, Phase 2
11 Hormone Antagonists Phase 1, Phase 2
12 Hormones Phase 1, Phase 2
13 Estrogen Receptor Antagonists Phase 1, Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rosuvastatin Effect on Telomere-telomerase System in ACS Unknown status NCT02299245 Phase 4 rosuvastatin
2 Evaluating Efficacy and Safety of Danazol in Severe Hematologic or Pulmonary Disease Related to Telomeropathy Not yet recruiting NCT03710356 Phase 1, Phase 2 Danazol 200 MG
3 Diet Quality and LTL in NHANES Completed NCT03302104
4 Brain Plasticity and Cellular Aging After Internet-delivered CBT for Social Anxiety Disorder Active, not recruiting NCT02592564 Not Applicable

Search NIH Clinical Center for Telomere Length, Mean Leukocyte

Genetic Tests for Telomere Length, Mean Leukocyte

Genetic tests related to Telomere Length, Mean Leukocyte:

# Genetic test Affiliating Genes
1 Telomere Length, Mean Leukocyte 29

Anatomical Context for Telomere Length, Mean Leukocyte

MalaCards organs/tissues related to Telomere Length, Mean Leukocyte:

41
Brain

Publications for Telomere Length, Mean Leukocyte

Variations for Telomere Length, Mean Leukocyte

ClinVar genetic disease variations for Telomere Length, Mean Leukocyte:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DCAF4 NM_015604.3(DCAF4): c.728+1334G> A single nucleotide variant Uncertain significance rs2535913 GRCh37 Chromosome 14, 73415233: 73415233
2 DCAF4 NM_015604.3(DCAF4): c.728+1334G> A single nucleotide variant Uncertain significance rs2535913 GRCh38 Chromosome 14, 72948525: 72948525

Expression for Telomere Length, Mean Leukocyte

Search GEO for disease gene expression data for Telomere Length, Mean Leukocyte.

Pathways for Telomere Length, Mean Leukocyte

GO Terms for Telomere Length, Mean Leukocyte

Sources for Telomere Length, Mean Leukocyte

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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