Temporal Lobe Epilepsy

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Aliases & Classifications for Temporal Lobe Epilepsy

MalaCards integrated aliases for Temporal Lobe Epilepsy:

Name: Temporal Lobe Epilepsy 11 14 36 16 75
Epilepsy, Temporal Lobe 11 43 71
Epilepsy Temporal Lobe 53


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Disease Ontology 11 DOID:3328
MeSH 43 D004833
NCIt 49 C177244
SNOMED-CT 68 84340007
UMLS 71 C0014556

Summaries for Temporal Lobe Epilepsy

MalaCards based summary: Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to epilepsy, familial temporal lobe, 7 and epilepsy, familial temporal lobe, 1, and has symptoms including seizures An important gene associated with Temporal Lobe Epilepsy is ADARB2-AS1 (ADARB2 Antisense RNA 1), and among its related pathways/superpathways are Neuroinflammation and glutamatergic signaling and Neuroscience. The drugs Citalopram and Dexetimide have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and amygdala, and related phenotypes are nervous system and normal

Wikipedia: 75 Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system which is characterized by... more...

Related Diseases for Temporal Lobe Epilepsy

Diseases in the Temporal Lobe Epilepsy family:

Epilepsy, Familial Temporal Lobe, 1 Epilepsy, Familial Temporal Lobe, 2
Epilepsy, Familial Temporal Lobe, 3 Epilepsy, Familial Temporal Lobe, 4
Epilepsy, Familial Temporal Lobe, 5 Epilepsy, Familial Temporal Lobe, 6
Epilepsy, Familial Temporal Lobe, 7 Epilepsy, Familial Temporal Lobe, 8

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 502)
# Related Disease Score Top Affiliating Genes
1 epilepsy, familial temporal lobe, 7 33.4 RELN LGI1
2 epilepsy, familial temporal lobe, 1 33.3 SCN1B RELN LGI1
3 autosomal dominant epilepsy with auditory features 32.8 RELN LGI1
4 status epilepticus 31.9 TSPO SLC1A2 PVALB NPY LGI1 GFAP
5 epilepsy 31.9 TSPO SV2B SLC1A2 SCN1B RELN PVALB
6 focal epilepsy 31.9 TSPO SLC1A2 PVALB PDYN NPY LGI1
7 amnestic disorder 31.6 TSPO PDYN LGI1 BDNF
8 mood disorder 31.5 RELN PDYN NPY GABBR1 BDNF
9 anxiety 31.5 TSPO PDYN NPY GABBR1 BDNF
10 ganglioglioma 31.4 SLC1A2 PVALB GFAP
11 major depressive disorder 31.4 TSPO PVALB PDYN NPY BDNF
12 psychotic disorder 31.3 SLC1A2 RELN PVALB PDYN NPY CALB1
13 epilepsy, idiopathic generalized 31.2 TSPO SCN1B PVALB LGI1 GABBR1
14 obsessive-compulsive disorder 31.1 PDYN NPY GABBR1 BDNF
15 dystonia 31.1 PVALB PDYN NPY GABBR1 BDNF
16 epilepsy, myoclonic juvenile 31.1 SCN1B PVALB LGI1 GABBR1
17 toxic encephalopathy 31.0 SLC1A2 GFAP BDNF
18 migraine with or without aura 1 30.9 SLC1A2 PDYN NPY GFAP BDNF
19 choreatic disease 30.9 PVALB LGI1 BDNF
20 post-traumatic stress disorder 30.9 PVALB NPY BDNF
21 attention deficit-hyperactivity disorder 30.8 RELN PVALB PDYN NPY BDNF
22 encephalomalacia 30.8 SLC1A2 GFAP BDNF
23 adjustment disorder 30.8 TSPO BDNF
24 neonatal hypoxic and ischemic brain injury 30.8 PVALB BDNF
25 childhood absence epilepsy 30.7 TSPO SLC1A2 SCN1B PVALB PDYN LGI1
26 anterograde amnesia 30.7 TSPO LGI1 BDNF
27 retrograde amnesia 30.7 LGI1 BDNF
28 generalized epilepsy with febrile seizures plus 30.7 SCN1B PVALB LGI1
29 substance abuse 30.7 PDYN NPY BDNF
30 west syndrome 30.6 SCN1B PVALB NPY LGI1
31 alzheimer disease, familial, 1 30.6 TSPO SLC1A2 RELN PVALB PDYN NPY
32 amyotrophic lateral sclerosis 1 30.5 TSPO SLC1A2 PVALB GFAP CALB1 BDNF
33 bipolar disorder 30.5 TSPO SLC1A2 RELN PVALB PDYN GFAP
34 withdrawal disorder 30.5 TSPO PDYN BDNF
35 alcohol use disorder 30.4 PDYN NPY BDNF
36 alexithymia 30.4 PDYN BDNF
37 tobacco addiction 30.4 PDYN GABBR2 BDNF
38 spinal cord injury 30.4 GFAP BDNF
39 speech and communication disorders 30.3 LGI1 GFAP BDNF
40 schizophrenia 30.3 TSPO SLC1A2 RELN PVALB PDYN NPY
41 motor neuron disease 30.2 SLC1A2 PVALB CALB1 BDNF
42 stroke, ischemic 30.2 TSPO SLC1A2 GFAP BDNF
43 nervous system disease 30.1 TSPO SLC1A2 PVALB PDYN NPY LGI1
44 huntington disease 30.1 TSPO SLC1A2 PDYN NPY2R NPY CALB1
45 epilepsy, familial temporal lobe, 2 11.9
46 epilepsy, familial temporal lobe, 5 11.8
47 mesial temporal lobe epilepsy with hippocampal sclerosis 11.8
48 epilepsy, familial temporal lobe, 3 11.7
49 epilepsy, familial temporal lobe, 8 11.7
50 epilepsy, familial temporal lobe, 6 11.7

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:

Diseases related to Temporal Lobe Epilepsy

Symptoms & Phenotypes for Temporal Lobe Epilepsy

UMLS symptoms related to Temporal Lobe Epilepsy:


MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.22 ACOT7 BDNF CALB1 CASP2 GABBR1 GABBR2
2 normal MP:0002873 10.02 BDNF CALB1 GFAP NPY PVALB SCN1B
3 growth/size/body region MP:0005378 10 ACOT7 BDNF GABBR1 GABBR2 GFAP LGI1
4 behavior/neurological MP:0005386 9.86 ACOT7 BDNF CALB1 GABBR1 GABBR2 GFAP
5 adipose tissue MP:0005375 9.8 ACOT7 GABBR1 LGI1 NPY NPY2R PDYN
6 mortality/aging MP:0010768 9.44 BDNF CASP2 GABBR1 GABBR2 GFAP LGI1

Drugs & Therapeutics for Temporal Lobe Epilepsy

Drugs for Temporal Lobe Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Citalopram Approved Phase 4 59729-32-7, 59729-33-8 2771
Dexetimide Withdrawn Phase 4 21888-98-2 30843
3 Psychotropic Drugs Phase 4
4 Antidepressive Agents Phase 4
5 Serotonin Uptake Inhibitors Phase 4
Naluzotan Investigational Phase 2 740873-06-7
7 Neurotransmitter Agents Phase 2
8 Serotonin Receptor Agonists Phase 2
9 Serotonin 5-HT1 Receptor Agonists Phase 2
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202
Sertraline Approved 79617-96-2 68617
Glutamic acid Approved, Nutraceutical 56-86-0 33032
13 Fluorodeoxyglucose F18
14 Anesthetics
15 Fluorides
16 Anticonvulsants

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy. A Double-blind, Placebo-controlled Study. Completed NCT00595699 Phase 4 escitalopram;placebo
2 Hippocampal and Thalamic Deep Brain Stimulation for Bilateral Temporal Lobe Epilepsy Recruiting NCT04164056 Phase 4
3 Early Randomized Surgical Epilepsy Trial Completed NCT00040326 Phase 3 antiepileptic drugs
4 Medical vs Electrical Therapy for Temporal Lobe Epilepsy Terminated NCT00717431 Phase 3
5 A First-In-Human (FIH) Study of Inhibitory Interneurons (NRTX- 1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE) Recruiting NCT05135091 Phase 1, Phase 2
6 A Phase II Clinical Trial of PRX-00023 Therapy in Localization-Related Epilepsy Terminated NCT01281956 Phase 2 PRX-00023;Placebo
7 Phase 1 Study of Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy Completed NCT00916266 Phase 1
8 Regenerating the Adult Human Brain Through Exercise Recruiting NCT05179083 Phase 1
9 Efficacy of Transcranial Direct Current Stimulation for Treating Working Memory Dysfunction and Depression For Patients With Temporal Lobe Epilepsy Withdrawn NCT02268578 Phase 1
10 Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery Unknown status NCT02590419
11 Role of Advanced Magnetic Resonance Imaging in Diagnosis of Idiopathic Temporal Lobe Epilepsy Unknown status NCT03643471
12 Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE) Unknown status NCT02383407
13 COMET Study Effectiveness of a Cognitive Remediation Program of Memory in Patients With Temporal Lobe Epilepsy Unknown status NCT02589470
14 Prospective Randomized Controlled Study of Vagus Nerve Stimulation Therapy in the Patients With Medically Refractory Medial Temporal Lobe Epilepsy; Controlled Randomized Vagus Nerve Stimulation Versus Resection (CoRaVNStiR) Unknown status NCT02089243
15 Prospective Randomized Controlled Study of Neurostimulation in the Medial Temporal Lobe for Patients With Medically Refractory Medial Temporal Lobe Epilepsy; Controlled Randomized Stimulation Versus Resection (CoRaStiR) Unknown status NCT00431457
16 Study on the Safety and Effects of Transcranial Direct Current Stimulation (tDCS) in the Treatment of Depressive Symptoms in Participants With Temporal Lobe Epilepsy: A Randomized, Double-blind, Sham-controlled Clinical Trial Unknown status NCT03871842
17 Stereotactic-EEG Guided Radio-frequency Thermocoagulation Versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy With Hippocampus Sclerosis Unknown status NCT03941613
18 Evaluation of Stress Sensitivity and Hyperemotivity in Temporal Lobe Epilepsy With Enlarged Amygdala Compared to Epilepsy Without Enlarged Amygdala (Temporal and Extra-temporal) and a Group of Healthy Volunteers: Pilot Study. Unknown status NCT03464370
19 Anticonvulsive Effects of Transcranial DC Stimulation in Pharmacoresistant Focal Epilepsy Completed NCT00344877
20 Closed Loop Auditory Stimulus in Sleep and epilepsY Completed NCT05159609
21 Subcutaneous EEG in Epilepsy - Proof of Concept and Clinical Applications Completed NCT02946151
22 Symmetricity-Driven Learning Framework for Pediatric Temporal Lobe Epilepsy Detection Using 18F-FDG-PET Imaging Completed NCT04169581
23 Radiosurgery Versus Lobectomy for Temporal Lobe Epilepsy Completed NCT00860145
24 Treatment Of Depression In Patients With Temporal Lobe Epilepsy: Comparative Study Of Cognitive Behavioral Therapy Vs. Selective Serotonin Reuptake Inhibitors Completed NCT02262156 SSRI
25 Functional MRI (fMRI) and Diffusion Tensor Imaging (DTI) in Temporal Lobe Epilepsy Completed NCT00081432
26 GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression Completed NCT00931619
27 Assessment of [11C]DPA-713 in Temporal Lobe Epilepsy Completed NCT01793532
28 Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy: New Targets for Diagnosis and Prediction of Drug Resistance Completed NCT01563627
29 Noninvasive Language Mapping in Patients With Localization-Related Epilepsy Completed NCT00706160
30 Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy Completed NCT00001672
31 Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation Completed NCT02339376
32 Brain Network Activation Analysis in Epilepsy Completed NCT03265925
33 Spectroscopic Determination of Brain Tumor Cells Completed NCT00067418
34 Electrophysiological Biomarkers During Invasive Monitoring of Mesial Temporal Lobe Epilepsy Patients. Recruiting NCT04710004
35 Stereotactic Laser Ablation for Temporal Lobe Epilepsy Recruiting NCT02844465
36 Functional Anterior Temporal Lobectomy Via Minicraniotomy as a Novel Surgical Therapy for Temporal Lobe Epilepsy: a Randomized, Controlled Trial Recruiting NCT05019404
37 Evaluation of the 24/7 EEG SubQ System for Ultra Long-Term Recording of Patients With Temporal Lobe Epilepsy An Open-label, Prospective, Paired, Comparative Study Recruiting NCT04526418
38 Cognitive and Emotional Function and Brain Reorganisation Associated to Auditory Abilities : Impact of Tinnitus Recruiting NCT04717388
39 Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics Recruiting NCT04649008 Early Phase 1
40 Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients Recruiting NCT05339438
41 Self-modulation of the Sense of Agency by Means of Real-time Neurofeedback Recruiting NCT05214833
42 Surgery as a Treatment for Medically Intractable Epilepsy Recruiting NCT01273129
43 Investigating Epilepsy: Screening and Evaluation Recruiting NCT03478852
44 EASINESS-TRIAL - An Analysis of Standardized Outcome References From an International Multicentre Cohort Recruiting NCT04952298
45 Gene Expression Changes of Brain Tissue in Human Temporal Lobe Epilepsy With Hippocampal Sclerosis Active, not recruiting NCT04917939
46 Thalamic Stimulation to Prevent Impaired Consciousness in Epilepsy Active, not recruiting NCT04897776
47 LIFUP for Treatment of Temporal Lobe Epilepsy Enrolling by invitation NCT02151175
48 Epilepsy Surgery and Cognition, Psychiatric Function and Quality of Life - Outcome 10 Years or More After Surgery Enrolling by invitation NCT04264780
49 Network Neuro-modulation for Mesial Temporal Lobe Epilepsy Not yet recruiting NCT05608408
50 Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy Not yet recruiting NCT05609084

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Phenytoin sodium

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: epilepsy, temporal lobe

Genetic Tests for Temporal Lobe Epilepsy

Anatomical Context for Temporal Lobe Epilepsy

Organs/tissues related to Temporal Lobe Epilepsy:

MalaCards : Temporal Lobe, Brain, Amygdala, Bone Marrow, Cortex, Bone, Thalamus

Publications for Temporal Lobe Epilepsy

Articles related to Temporal Lobe Epilepsy:

(show top 50) (show all 12045)
# Title Authors PMID Year
Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families. 53 62
19780791 2010
Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. 53 62
20437582 2010
Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. 53 62
19833108 2010
Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. 53 62
19864112 2010
Aberrant glutamate receptor 5 expression in temporal lobe epilepsy lesions. 53 62
19941835 2010
Conditional downregulation of brain- derived neurotrophic factor and tyrosine kinase receptor B blocks epileptogenesis in the human temporal lobe epilepsy hippocampus. 53 62
20228460 2010
The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study. 53 62
19747915 2009
[Expression and function of Cx32 and Cx43 junctions in medically intractable temporal lobe epilepsy in human]. 53 62
20137634 2009
Using cerebral white matter for estimation of nondisplaceable binding of 5-HT1A receptors in temporal lobe epilepsy. 53 62
19837769 2009
Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy. 53 62
19437412 2009
Positive correlation between the density of neuropeptide y positive neurons in the amygdala and parameters of self-reported anxiety and depression in mesiotemporal lobe epilepsy patients. 53 62
19482265 2009
Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy. 53 62
19287316 2009
Haploinsufficiency of glutamine synthetase increases susceptibility to experimental febrile seizures. 53 62
19170755 2009
Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP. 53 62
19038255 2009
Candidate genes for temporal lobe epilepsy: a replication study. 53 62
19066720 2008
[Aquaporin-4]. 53 62
19198125 2008
Association between the gamma-aminobutyric acid type B receptor 1 and 2 gene polymorphisms and mesial temporal lobe epilepsy in a Han Chinese population. 53 62
18653317 2008
GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: new evidence. 53 62
18255321 2008
M129V polymorphism in the prion protein gene is not associated with mesial temporal lobe epilepsy in a Han Chinese population. 53 62
18549399 2008
Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. 53 62
18477594 2008
Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. 53 62
18509280 2008
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain. 53 62
18394657 2008
Analysis of LGI1 promoter sequence, PDYN and GABBR1 polymorphisms in sporadic and familial lateral temporal lobe epilepsy. 53 62
18355961 2008
Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. 53 62
18326497 2008
Genetic etiology of new forms of familial epilepsy. 53 62
17981785 2008
Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy? 53 62
18226171 2008
Transcriptionally less active prodynorphin promoter alleles are associated with temporal lobe epilepsy: a case-control study and meta-analysis. 53 62
18334734 2008
The NR1 N-methyl-D-aspartate subunit and brain-derived neurotrophic factor in temporal lobe epilepsy hippocampus: a comparison of patients with and without coexisting psychiatric symptoms. 53 62
17919302 2007
5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression. 53 62
17588547 2007
Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. 53 62
17484754 2007
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. 53 62
17446080 2007
Seizure suppression by GDNF gene therapy in animal models of epilepsy. 53 62
17387333 2007
Limbic encephalitis with autoantibodies against the glutamate receptor epsilon 2 mimicking temporal lobe epilepsy. 53 62
17472608 2007
Association between the M129V variant allele of PRNP gene and mild temporal lobe epilepsy in women. 53 62
17092648 2007
Hippocampal Nogo-A and neo-Timm's staining in amygdala kindling rats. 53 62
17439704 2007
Neuropeptide Y in the dentate gyrus. 53 62
17765725 2007
Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. 53 62
17020904 2007
Potentiation of anti-epileptic drugs effectiveness by pyronaridine in refractory epilepsy. 53 62
17368747 2007
Viral risk factor for seizures: pathobiology of dynorphin in herpes simplex viral (HSV-1) seizures in an animal model. 53 62
16843674 2006
Syntaxin 1A promotes the endocytic sorting of EAAC1 leading to inhibition of glutamate transport. 53 62
16959903 2006
Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy. 53 62
16922873 2006
Architectural (Type IA) focal cortical dysplasia and parvalbumin immunostaining in temporal lobe epilepsy. 53 62
16822257 2006
Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease. 53 62
16772867 2006
Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171. 53 62
16580884 2006
Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. 53 62
16650133 2006
The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. 53 62
16504945 2006
Influence of lamotrigine and topiramate on MDR1 expression in difficult-to-treat temporal lobe epilepsy. 53 62
16499746 2006
Lack of association between a GABA receptor 1 gene polymorphism and temporal lobe epilepsy. 53 62
16499773 2006
Implications of the aquaporin-4 structure on array formation and cell adhesion. 53 62
16325200 2006
Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients. 53 62
16311265 2006

Variations for Temporal Lobe Epilepsy

Expression for Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for Temporal Lobe Epilepsy

GO Terms for Temporal Lobe Epilepsy

Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 10.01 SLC1A2 SCN1B PVALB CALB1 BDNF
2 cuticular plate GO:0032437 9.67 PVALB CALB1
3 synapse GO:0045202 9.65 SV2B SLC1A2 PVALB PDYN LGI1 GABBR2
4 G protein-coupled receptor heterodimeric complex GO:0038039 9.56 GABBR2 GABBR1
5 GABA receptor complex GO:1902710 9.5 GABBR2 GABBR1
6 G protein-coupled GABA receptor complex GO:1902712 9.46 GABBR1 GABBR2
7 neuron projection GO:0043005 9.4 SV2B RELN NPY2R NPY GABBR2 GABBR1

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon guidance GO:0007411 10.01 SCN1B RELN LGI1 BDNF
2 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.85 NPY2R GABBR2 GABBR1
3 neuron projection development GO:0031175 9.8 SCN1B NPY LGI1 GFAP
4 chemical synaptic transmission GO:0007268 9.65 SV2B SLC1A2 PDYN NPY GABBR2
5 D-aspartate import across plasma membrane GO:0070779 9.56 GFAP SLC1A2
6 neuron-glial cell signaling GO:0150099 9.46 GABBR1 GABBR2
7 regulation of presynaptic cytosolic calcium ion concentration GO:0099509 8.92 SV2B NPY CALB1

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled GABA receptor activity GO:0004965 8.92 GABBR2 GABBR1

Sources for Temporal Lobe Epilepsy

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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