MCID: TMP001
MIFTS: 50

Temporal Lobe Epilepsy

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Temporal Lobe Epilepsy

MalaCards integrated aliases for Temporal Lobe Epilepsy:

Name: Temporal Lobe Epilepsy 12 15 37 17
Epilepsy, Temporal Lobe 12 43 71
Epilepsy Temporal Lobe 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3328
MeSH 43 D004833
SNOMED-CT 67 84340007
UMLS 71 C0014556

Summaries for Temporal Lobe Epilepsy

MalaCards based summary : Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to autosomal dominant epilepsy with auditory features and status epilepticus, and has symptoms including seizures An important gene associated with Temporal Lobe Epilepsy is ADARB2-AS1 (ADARB2 Antisense RNA 1), and among its related pathways/superpathways are cAMP signaling pathway and Neuroscience. The drugs Citalopram and Oxcarbazepine have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and amygdala, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 74 Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system characterized by recurrent,... more...

Related Diseases for Temporal Lobe Epilepsy

Diseases in the Temporal Lobe Epilepsy family:

Epilepsy, Familial Temporal Lobe, 1 Epilepsy, Familial Temporal Lobe, 2
Epilepsy, Familial Temporal Lobe, 3 Epilepsy, Familial Temporal Lobe, 4
Epilepsy, Familial Temporal Lobe, 5 Epilepsy, Familial Temporal Lobe, 6
Epilepsy, Familial Temporal Lobe, 7 Epilepsy, Familial Temporal Lobe, 8

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 395)
# Related Disease Score Top Affiliating Genes
1 autosomal dominant epilepsy with auditory features 33.8 RELN LGI1
2 status epilepticus 31.9 TSPO SLC1A2 PVALB NPY LGI1 GFAP
3 amnestic disorder 31.7 TSPO PDYN LGI1 BDNF
4 mood disorder 31.6 RELN NPY GFAP BDNF
5 epilepsy 31.6 TSPO SV2B SLC1A2 SCN1B RELN PVALB
6 ganglioglioma 31.6 SLC1A2 RELN PVALB GFAP
7 anxiety 31.4 TSPO PDYN NPY GABBR1 BDNF
8 psychotic disorder 31.4 RELN PVALB PDYN BDNF
9 traumatic brain injury 31.4 GFAP BDNF
10 dystonia 31.3 PVALB PDYN NPY GABBR1 BDNF
11 epilepsy, idiopathic generalized 31.3 SCN1B PVALB LGI1 GABBR1
12 epilepsy, myoclonic juvenile 31.2 SCN1B LGI1 GABBR1 CPA6
13 hydrocephalus 31.2 RELN NPY GFAP BDNF
14 obsessive-compulsive disorder 31.2 PDYN NPY GABBR1 BDNF
15 focal epilepsy 31.2 TSPO SLC1A2 SCN1B RELN PVALB PDYN
16 encephalomalacia 31.1 SLC1A2 GFAP BDNF
17 migraine with or without aura 1 31.0 SLC1A3 SLC1A2 NPY BDNF
18 electroclinical syndrome 30.9 SCN1B PVALB LGI1
19 adjustment disorder 30.9 TSPO NPY BDNF
20 transient global amnesia 30.9 LGI1 BDNF
21 leukoencephalopathy, hereditary diffuse, with spheroids 30.8 SLC1A3 SLC1A2 GFAP
22 substance abuse 30.8 PDYN NPY BDNF
23 generalized epilepsy with febrile seizures plus 30.8 SCN1B PVALB LGI1
24 neonatal hypoxic and ischemic brain injury 30.7 SLC1A3 PVALB BDNF
25 bipolar disorder 30.7 TSPO SLC1A2 RELN PVALB PDYN GABBR1
26 generalized anxiety disorder 30.6 TSPO NPY BDNF
27 retrograde amnesia 30.6 PDYN BDNF
28 major depressive disorder 30.6 SLC1A3 SLC1A2 NPY BDNF
29 anterograde amnesia 30.6 LGI1 BDNF
30 gangliocytoma 30.5 PVALB GFAP
31 aceruloplasminemia 30.5 SLC1A3 PDYN GFAP CALB1
32 schizophrenia 30.4 TSPO SLC1A3 SLC1A2 RELN PVALB PDYN
33 alcohol use disorder 30.4 GABBR2 GABBR1 BDNF
34 amyotrophic lateral sclerosis 1 30.4 TSPO SLC1A3 SLC1A2 PVALB GFAP CALB1
35 gilles de la tourette syndrome 30.3 SLC1A3 PVALB BDNF
36 autism 30.3 SLC1A3 RELN GFAP GABBR2 GABBR1 CALB1
37 motor neuron disease 30.3 SLC1A3 SLC1A2 PVALB CALB1 BDNF
38 huntington disease 30.3 TSPO SLC1A2 NPY CALB1 BDNF
39 childhood absence epilepsy 30.1 TSPO SLC1A2 SCN1B PVALB PDYN LGI1
40 alzheimer disease 30.1 TSPO SLC1A3 SLC1A2 RELN PVALB PDYN
41 mesial temporal lobe epilepsy with hippocampal sclerosis 12.9
42 benign familial mesial temporal lobe epilepsy 12.6
43 epilepsy, familial temporal lobe, 1 12.5
44 epilepsy, familial temporal lobe, 2 12.5
45 infantile-onset mesial temporal lobe epilepsy with severe cognitive regression 12.5
46 epilepsy, familial temporal lobe, 3 12.5
47 epilepsy, familial temporal lobe, 5 12.3
48 epilepsy, familial temporal lobe, 6 12.3
49 epilepsy, familial temporal lobe, 8 12.3
50 epilepsy, familial temporal lobe, 7 12.2

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to Temporal Lobe Epilepsy

Symptoms & Phenotypes for Temporal Lobe Epilepsy

UMLS symptoms related to Temporal Lobe Epilepsy:


seizures

MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.22 ACOT7 BDNF CALB1 GABBR1 GABBR2 GFAP
2 growth/size/body region MP:0005378 10.07 ACOT7 BDNF GABBR1 GABBR2 GFAP LGI1
3 nervous system MP:0003631 10.03 ACOT7 BDNF CALB1 GABBR1 GABBR2 GFAP
4 normal MP:0002873 9.61 BDNF CALB1 GFAP NPY PVALB SCN1B
5 vision/eye MP:0005391 9.23 BDNF GFAP LGI1 PVALB RELN SCN1B

Drugs & Therapeutics for Temporal Lobe Epilepsy

Drugs for Temporal Lobe Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2
Oxcarbazepine Approved Phase 4 28721-07-5 34312
3
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
4
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
5
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
6 Serotonin Uptake Inhibitors Phase 4
7 Muscarinic Antagonists Phase 4
8 Antidepressive Agents Phase 4
9 Cholinergic Agents Phase 4
10 Autonomic Agents Phase 4
11 Antiparkinson Agents Phase 4
12 Cholinergic Antagonists Phase 4
13 Parasympatholytics Phase 4
14 Cytochrome P-450 CYP3A Inducers Phase 4
15 Analgesics, Non-Narcotic Phase 4
16 Sodium Channel Blockers Phase 4
17 Diuretics, Potassium Sparing Phase 4
18 Analgesics Phase 4
19 Anticonvulsants Phase 4
20 Neurotransmitter Agents Phase 4
21 Psychotropic Drugs Phase 4
22 Tranquilizing Agents Phase 4
23 Central Nervous System Depressants Phase 4
24 Antimanic Agents Phase 4
25 Protective Agents Phase 4
26 Antioxidants Phase 4
27 GABA Agents Phase 4
28
Carvedilol Approved, Investigational Phase 2, Phase 3 72956-09-3 2585
29
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
30 Immunologic Factors Phase 2, Phase 3
31 Anti-Bacterial Agents Phase 2, Phase 3
32 interferons Phase 2, Phase 3
33 Hormones Phase 2, Phase 3
34 Adrenergic alpha-Antagonists Phase 2, Phase 3
35 Adrenergic Antagonists Phase 2, Phase 3
36 Anti-Infective Agents Phase 2, Phase 3
37 Antihypertensive Agents Phase 2, Phase 3
38 Adrenergic beta-Antagonists Phase 2, Phase 3
39 Antibiotics, Antitubercular Phase 2, Phase 3
40 Antiviral Agents Phase 2, Phase 3
41 Adjuvants, Immunologic Phase 2, Phase 3
42 polysaccharide-K Phase 2, Phase 3
43 calcium channel blockers Phase 2, Phase 3
44 Calcium, Dietary Phase 2, Phase 3
45 Vasodilator Agents Phase 2, Phase 3
46 Radiation-Protective Agents Phase 2, Phase 3
47 Interferon Inducers Phase 2, Phase 3
48 Adrenergic Agents Phase 2, Phase 3
49
Buspirone Approved, Investigational Phase 2 36505-84-7 2477
50 Naluzotan Investigational Phase 2 740873-06-7

Interventional clinical trials:

(show top 50) (show all 66)
# Name Status NCT ID Phase Drugs
1 Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy. A Double-blind, Placebo-controlled Study. Completed NCT00595699 Phase 4 escitalopram;placebo
2 Effect of Carbamazepine and Oxcarbazepine on Serum Neuron-specific Enolase and S100B in Focal Seizures Completed NCT02705768 Phase 4 Carbamazepine;Oxcarbazepine
3 Hippocampal and Thalamic Deep Brain Stimulation for Bilateral Temporal Lobe Epilepsy Recruiting NCT04164056 Phase 4
4 Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Seizure: A Randomized, add-on Placebo-controlled Clinical Trial Recruiting NCT03590197 Phase 4 Melatonin 3 mg
5 Early Randomized Surgical Epilepsy Trial Completed NCT00040326 Phase 3 antiepileptic drugs
6 Medical vs Electrical Therapy for Temporal Lobe Epilepsy Terminated NCT00717431 Phase 3
7 An Open-label Pilot Study Using Carvedilol-CR as a P-glycoprotein Inhibitor as Adjunct Therapy in the Treatment of Medically-refractory Epilepsy Terminated NCT00524134 Phase 2, Phase 3 Carvedilol-CR
8 A Phase Two Clinical Trial of Buspirone Therapy in Localization-Related Epilepsy Terminated NCT01496612 Phase 2 Buspirone
9 A Phase II Clinical Trial of PRX-00023 Therapy in Localization-Related Epilepsy Terminated NCT01281956 Phase 2 PRX-00023;Placebo
10 Phase 1 Study of Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy Completed NCT00916266 Phase 1
11 Human Safety and Feasibility Study of Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy Recruiting NCT03946618 Phase 1
12 Efficacy of Transcranial Direct Current Stimulation for Treating Working Memory Dysfunction and Depression For Patients With Temporal Lobe Epilepsy Withdrawn NCT02268578 Phase 1
13 Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE) Unknown status NCT02383407
14 Prospective Randomized Controlled Study of Vagus Nerve Stimulation Therapy in the Patients With Medically Refractory Medial Temporal Lobe Epilepsy; Controlled Randomized Vagus Nerve Stimulation Versus Resection (CoRaVNStiR) Unknown status NCT02089243
15 Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery Unknown status NCT02590419
16 Near Death Experience (NDE) and Migraine Unknown status NCT02854930
17 Prospective Randomized Controlled Study of Neurostimulation in the Medial Temporal Lobe for Patients With Medically Refractory Medial Temporal Lobe Epilepsy; Controlled Randomized Stimulation Versus Resection (CoRaStiR) Unknown status NCT00431457
18 Emotional Processing and Memory Evaluation in Epilepsy Patients Unknown status NCT00486239 Early Phase 1
19 Symmetricity-Driven Learning Framework for Pediatric Temporal Lobe Epilepsy Detection Using 18F-FDG-PET Imaging Completed NCT04169581
20 Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy: New Targets for Diagnosis and Prediction of Drug Resistance Completed NCT01563627
21 Treatment Of Depression In Patients With Temporal Lobe Epilepsy: Comparative Study Of Cognitive Behavioral Therapy Vs. Selective Serotonin Reuptake Inhibitors Completed NCT02262156 SSRI
22 Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy Completed NCT00001672
23 Subcutaneous EEG in Epilepsy - Proof of Concept and Clinical Applications Completed NCT02946151
24 Anticonvulsive Effects of Transcranial DC Stimulation in Pharmacoresistant Focal Epilepsy Completed NCT00344877
25 Spectroscopic Determination of Brain Tumor Cells Completed NCT00067418
26 Functional MRI (fMRI) and Diffusion Tensor Imaging (DTI) in Temporal Lobe Epilepsy Completed NCT00081432
27 Noninvasive Language Mapping in Patients With Localization-Related Epilepsy Completed NCT00706160
28 GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression Completed NCT00931619
29 Assessment of [11C]DPA-713 in Temporal Lobe Epilepsy Completed NCT01793532
30 Brain Network Activation Analysis in Epilepsy Completed NCT03265925
31 PET Imaging of Serotonin Receptors in Seizure Disorders Completed NCT00001932
32 Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery Completed NCT03102957
33 Radiosurgery Versus Lobectomy for Temporal Lobe Epilepsy Completed NCT00860145
34 Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery Principal Investigator: Elizabeth VITTE Completed NCT01285921
35 Does Memantine Improve Verbal Memory Task Performance in Subjects With Localization-related Epilepsy and Memory Dysfunction? A Randomized, Double-Blind, Placebo-Controlled Trial Completed NCT01054599 Memantine;Memantine
36 Multimodal Image-guided Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Refractory Partial Epilepsy. Completed NCT01745952
37 Positron Emission Tomography Measurement of Neuroinflammation in Focal Epilepsy Completed NCT01663545
38 PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in Neurological Disorders Completed NCT00613119
39 Dopaminergic Reactivity In Idiopathic Generalized Epilepsy: A "Proof Of Concept" Clinical, Pharmacological And Neurophysiological Study Completed NCT01432821
40 Repetitive Transcranial Magnetic Stimulation as Treatment for Acute Suicidality in Adult Patients Completed NCT02693743
41 LIFUP for Treatment of Temporal Lobe Epilepsy Recruiting NCT02151175
42 Stereotactic Laser Ablation for Temporal Lobe Epilepsy Recruiting NCT02844465
43 Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation Recruiting NCT02339376
44 Stereotactic-EEG Guided Radio-frequency Thermocoagulation Versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy With Hippocampus Sclerosis Recruiting NCT03941613
45 Role of Advanced Magnetic Resonance Imaging in Diagnosis of Idiopathic Temporal Lobe Epilepsy Recruiting NCT03643471
46 Study on the Safety and Effects of Transcranial Direct Current Stimulation (tDCS) in the Treatment of Depressive Symptoms in Participants With Temporal Lobe Epilepsy: A Randomized, Double-blind, Sham-controlled Clinical Trial Recruiting NCT03871842
47 Surgery as a Treatment for Medically Intractable Epilepsy Recruiting NCT01273129
48 Investigating Epilepsy: Screening, Evaluation and Treatment Recruiting NCT03478852
49 COMET Study Effectiveness of a Cognitive Remediation Program of Memory in Patients With Temporal Lobe Epilepsy Recruiting NCT02589470
50 Low Intensity Focused Ultrasound Treatment for Drug-Resistant Epilepsy: An Efficacy Trial Recruiting NCT03868293

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Mephenytoin
Phenytoin
Phenytoin sodium
PHENYTOIN SODIUM,EXTENDED
PHENYTOIN SODIUM,PROMPT

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: epilepsy, temporal lobe

Genetic Tests for Temporal Lobe Epilepsy

Anatomical Context for Temporal Lobe Epilepsy

MalaCards organs/tissues related to Temporal Lobe Epilepsy:

40
Temporal Lobe, Brain, Amygdala, Cortex, Testes, Heart, Bone

Publications for Temporal Lobe Epilepsy

Articles related to Temporal Lobe Epilepsy:

(show top 50) (show all 10420)
# Title Authors PMID Year
1
Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. 54 61
20437582 2010
2
Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families. 54 61
19780791 2010
3
Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. 54 61
19864112 2010
4
Conditional downregulation of brain- derived neurotrophic factor and tyrosine kinase receptor B blocks epileptogenesis in the human temporal lobe epilepsy hippocampus. 54 61
20228460 2010
5
Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. 54 61
19833108 2010
6
Aberrant glutamate receptor 5 expression in temporal lobe epilepsy lesions. 54 61
19941835 2010
7
The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study. 54 61
19747915 2009
8
Using cerebral white matter for estimation of nondisplaceable binding of 5-HT1A receptors in temporal lobe epilepsy. 54 61
19837769 2009
9
Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy. 54 61
19437412 2009
10
[Expression and function of Cx32 and Cx43 junctions in medically intractable temporal lobe epilepsy in human]. 54 61
20137634 2009
11
Positive correlation between the density of neuropeptide y positive neurons in the amygdala and parameters of self-reported anxiety and depression in mesiotemporal lobe epilepsy patients. 54 61
19482265 2009
12
Haploinsufficiency of glutamine synthetase increases susceptibility to experimental febrile seizures. 54 61
19170755 2009
13
Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy. 54 61
19287316 2009
14
Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP. 54 61
19038255 2009
15
Candidate genes for temporal lobe epilepsy: a replication study. 54 61
19066720 2008
16
[Aquaporin-4]. 54 61
19198125 2008
17
Association between the gamma-aminobutyric acid type B receptor 1 and 2 gene polymorphisms and mesial temporal lobe epilepsy in a Han Chinese population. 54 61
18653317 2008
18
GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: new evidence. 54 61
18255321 2008
19
M129V polymorphism in the prion protein gene is not associated with mesial temporal lobe epilepsy in a Han Chinese population. 54 61
18549399 2008
20
Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. 54 61
18477594 2008
21
Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. 54 61
18509280 2008
22
Analysis of LGI1 promoter sequence, PDYN and GABBR1 polymorphisms in sporadic and familial lateral temporal lobe epilepsy. 54 61
18355961 2008
23
Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. 54 61
18326497 2008
24
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain. 54 61
18394657 2008
25
Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy? 54 61
18226171 2008
26
Transcriptionally less active prodynorphin promoter alleles are associated with temporal lobe epilepsy: a case-control study and meta-analysis. 54 61
18334734 2008
27
Genetic etiology of new forms of familial epilepsy. 54 61
17981785 2008
28
The NR1 N-methyl-D-aspartate subunit and brain-derived neurotrophic factor in temporal lobe epilepsy hippocampus: a comparison of patients with and without coexisting psychiatric symptoms. 54 61
17919302 2007
29
5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression. 54 61
17588547 2007
30
Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. 54 61
17484754 2007
31
Limbic encephalitis with autoantibodies against the glutamate receptor epsilon 2 mimicking temporal lobe epilepsy. 54 61
17472608 2007
32
Association between the M129V variant allele of PRNP gene and mild temporal lobe epilepsy in women. 54 61
17092648 2007
33
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. 54 61
17446080 2007
34
Seizure suppression by GDNF gene therapy in animal models of epilepsy. 54 61
17387333 2007
35
Hippocampal Nogo-A and neo-Timm's staining in amygdala kindling rats. 54 61
17439704 2007
36
Neuropeptide Y in the dentate gyrus. 54 61
17765725 2007
37
Potentiation of anti-epileptic drugs effectiveness by pyronaridine in refractory epilepsy. 54 61
17368747 2007
38
Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. 54 61
17020904 2007
39
Viral risk factor for seizures: pathobiology of dynorphin in herpes simplex viral (HSV-1) seizures in an animal model. 54 61
16843674 2006
40
Syntaxin 1A promotes the endocytic sorting of EAAC1 leading to inhibition of glutamate transport. 54 61
16959903 2006
41
Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy. 54 61
16922873 2006
42
Architectural (Type IA) focal cortical dysplasia and parvalbumin immunostaining in temporal lobe epilepsy. 54 61
16822257 2006
43
Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease. 54 61
16772867 2006
44
Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171. 54 61
16580884 2006
45
Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. 54 61
16650133 2006
46
The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. 54 61
16504945 2006
47
Influence of lamotrigine and topiramate on MDR1 expression in difficult-to-treat temporal lobe epilepsy. 54 61
16499746 2006
48
Lack of association between a GABA receptor 1 gene polymorphism and temporal lobe epilepsy. 54 61
16499773 2006
49
Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients. 54 61
16311265 2006
50
Implications of the aquaporin-4 structure on array formation and cell adhesion. 54 61
16325200 2006

Variations for Temporal Lobe Epilepsy

Expression for Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for Temporal Lobe Epilepsy

GO Terms for Temporal Lobe Epilepsy

Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.77 RELN PDYN GABBR1 CALB1 BDNF
2 neuron projection GO:0043005 9.65 SV2B SLC1A3 RELN GABBR2 CALB1
3 axon GO:0030424 9.55 SLC1A2 SCN1B PVALB CALB1 BDNF
4 cuticular plate GO:0032437 9.32 PVALB CALB1
5 synapse GO:0045202 9.17 SV2B SLC1A3 NPY LGI1 GABBR2 GABBR1
6 G protein-coupled receptor heterodimeric complex GO:0038039 8.96 GABBR2 GABBR1

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron projection development GO:0010976 9.63 SCN1B RELN BDNF
2 axon guidance GO:0007411 9.56 SCN1B RELN LGI1 BDNF
3 response to wounding GO:0009611 9.5 SLC1A3 SLC1A2 GFAP
4 positive regulation of synaptic transmission GO:0050806 9.48 SLC1A3 LGI1
5 response to pain GO:0048265 9.43 TSPO RELN
6 positive regulation of glial cell proliferation GO:0060252 9.4 TSPO GFAP
7 L-glutamate transmembrane transport GO:0015813 9.37 SLC1A3 SLC1A2
8 L-glutamate import across plasma membrane GO:0098712 9.16 SLC1A3 SLC1A2
9 chemical synaptic transmission GO:0007268 9.1 SV2B SLC1A3 SLC1A2 PDYN NPY GABBR2
10 D-aspartate import across plasma membrane GO:0070779 8.96 SLC1A3 SLC1A2

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 L-glutamate transmembrane transporter activity GO:0005313 9.26 SLC1A3 SLC1A2
2 high-affinity glutamate transmembrane transporter activity GO:0005314 9.16 SLC1A3 SLC1A2
3 glutamate:sodium symporter activity GO:0015501 8.96 SLC1A3 SLC1A2
4 G protein-coupled GABA receptor activity GO:0004965 8.62 GABBR2 GABBR1

Sources for Temporal Lobe Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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