MCID: TMP001
MIFTS: 57

Temporal Lobe Epilepsy

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Temporal Lobe Epilepsy

MalaCards integrated aliases for Temporal Lobe Epilepsy:

Name: Temporal Lobe Epilepsy 39 12 15 17
Epilepsy, Temporal Lobe 12 45 74
Epilepsy Temporal Lobe 56

Classifications:



External Ids:

Disease Ontology 12 DOID:3328
MeSH 45 D004833
SNOMED-CT 69 84340007
UMLS 74 C0014556

Summaries for Temporal Lobe Epilepsy

MalaCards based summary : Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to epilepsy, familial temporal lobe, 1 and autosomal dominant epilepsy with auditory features, and has symptoms including seizures An important gene associated with Temporal Lobe Epilepsy is ADARB2-AS1 (ADARB2 Antisense RNA 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Circadian entrainment. The drugs Citalopram and Amitriptyline have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and amygdala, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 77 Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system characterized by recurrent,... more...

Related Diseases for Temporal Lobe Epilepsy

Diseases in the Temporal Lobe Epilepsy family:

Epilepsy, Familial Temporal Lobe, 1 Epilepsy, Familial Temporal Lobe, 2
Epilepsy, Familial Temporal Lobe, 3 Epilepsy, Familial Temporal Lobe, 4
Epilepsy, Familial Temporal Lobe, 5 Epilepsy, Familial Temporal Lobe, 6
Epilepsy, Familial Temporal Lobe, 7 Epilepsy, Familial Temporal Lobe, 8

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 epilepsy, familial temporal lobe, 1 33.7 LGI1 RELN
2 autosomal dominant epilepsy with auditory features 32.8 LGI1 RELN
3 epilepsy 32.4 BDNF GABBR1 GAD1 LGI1 RELN SCN1B
4 depression 31.6 BDNF HTR1A RELN
5 status epilepticus 31.4 BDNF GFAP LGI1 NPY
6 anxiety 31.0 BDNF HTR1A NPY TSPO
7 encephalitis 31.0 GFAP LGI1 TSPO
8 mood disorder 30.7 BDNF HTR1A NPY
9 obsessive-compulsive disorder 30.7 BDNF HTR1A PDYN
10 major depressive disorder 30.6 BDNF GAD1 HTR1A NPY
11 dysembryoplastic neuroepithelial tumor 30.6 GFAP GRIN1
12 psychotic disorder 30.5 BDNF HTR1A RELN
13 amnestic disorder 30.5 BDNF HTR1A LGI1 PDYN TSPO
14 epilepsy, idiopathic generalized 30.4 GABBR1 LGI1 SCN1B TSPO
15 bipolar disorder 30.4 BDNF GAD1 HTR1A RELN
16 focal epilepsy 30.3 LGI1 PDYN TSPO
17 childhood absence epilepsy 30.0 GABBR1 GRIK1 SCN1B
18 schizophrenia 29.7 BDNF GABBR1 GAD1 GRIK1 GRIN1 HTR1A
19 autism 29.6 BDNF GAD1 HTR1A RELN
20 mesial temporal lobe epilepsy with hippocampal sclerosis 12.6
21 benign familial mesial temporal lobe epilepsy 12.4
22 infantile-onset mesial temporal lobe epilepsy with severe cognitive regression 12.4
23 epilepsy, familial temporal lobe, 2 12.4
24 epilepsy, familial temporal lobe, 3 12.3
25 epilepsy, familial temporal lobe, 7 12.0
26 epilepsy, familial temporal lobe, 4 12.0
27 epilepsy, familial temporal lobe, 5 11.9
28 epilepsy, familial temporal lobe, 6 11.9
29 epilepsy, familial temporal lobe, 8 11.9
30 temporal epilepsy, familial 11.9
31 autosomal dominant partial epilepsy with auditory features 11.8
32 epilepsy, familial focal, with variable foci 2 11.4
33 epilepsy, familial focal, with variable foci 3 11.4
34 febrile seizures, familial, 11 11.4
35 lipoid proteinosis of urbach and wiethe 11.2
36 epilepsy, nocturnal frontal lobe, 1 11.2
37 mental retardation, anterior maxillary protrusion, and strabismus 11.2
38 epilepsy, familial focal, with variable foci 4 11.2
39 seizure disorder 10.7
40 febrile seizures 10.6
41 dissociative amnesia 10.4 HTR1A PDYN
42 suppression amblyopia 10.4 GABBR1 GRIN1
43 neonatal hypoxic and ischemic brain injury 10.4 BDNF SLC1A3
44 childhood disintegrative disease 10.4 BDNF LGI1
45 cysticercosis 10.4
46 generalized anxiety disorder 10.3 BDNF HTR1A TSPO
47 endogenous depression 10.3 BDNF HTR1A NPY
48 syncope 10.3
49 spinal cord injury 10.3 BDNF GFAP PDYN
50 toxic encephalopathy 10.3 BDNF GFAP SLC1A2

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to Temporal Lobe Epilepsy

Symptoms & Phenotypes for Temporal Lobe Epilepsy

UMLS symptoms related to Temporal Lobe Epilepsy:


seizures

MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 BDNF GABBR1 GABBR2 GAD1 GFAP GRIK1
2 growth/size/body region MP:0005378 10.28 BDNF GABBR1 GABBR2 GAD1 GFAP GRIK1
3 mortality/aging MP:0010768 10.17 BDNF GABBR1 GABBR2 GAD1 GFAP GRIN1
4 nervous system MP:0003631 10.16 BDNF GABBR1 GABBR2 GAD1 GFAP GRIK1
5 homeostasis/metabolism MP:0005376 10.15 BDNF GABBR1 GABBR2 GAD1 GFAP GRIN1
6 no phenotypic analysis MP:0003012 9.7 BDNF GAD1 GRIN1 HTR1A PDYN SCN1B
7 normal MP:0002873 9.65 BDNF GAD1 GFAP GRIK1 GRIN1 NPY
8 vision/eye MP:0005391 9.23 BDNF GFAP GRIN1 LGI1 RELN SCN1B

Drugs & Therapeutics for Temporal Lobe Epilepsy

Drugs for Temporal Lobe Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4,Not Applicable 59729-33-8 2771
2
Amitriptyline Approved Phase 4 50-48-6 2160
3
Perphenazine Approved Phase 4 58-39-9 4748
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5 Parasympatholytics Phase 4
6 Antidepressive Agents Phase 4,Not Applicable
7 Neurotransmitter Uptake Inhibitors Phase 4,Not Applicable
8 Peripheral Nervous System Agents Phase 4
9 Antiparkinson Agents Phase 4,Not Applicable
10 Cholinergic Agents Phase 4
11 Cholinergic Antagonists Phase 4
12 Antidepressive Agents, Second-Generation Phase 4
13 Autonomic Agents Phase 4
14 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
15 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
16 Serotonin Agents Phase 4,Phase 2,Not Applicable
17 Serotonin Uptake Inhibitors Phase 4,Not Applicable
18 Muscarinic Antagonists Phase 4
19 Anesthetics Phase 4,Not Applicable
20 Antidepressive Agents, Tricyclic Phase 4
21 Diuretics, Potassium Sparing Phase 4
22 Analgesics, Non-Narcotic Phase 4
23 Tranquilizing Agents Phase 4,Phase 2
24 Adrenergic Agents Phase 4
25 Analgesics Phase 4
26 Amitriptyline, perphenazine drug combination Phase 4
27 Antipsychotic Agents Phase 4
28 Anesthetics, Local Phase 4
29 Sodium Channel Blockers Phase 4
30 Anti-Arrhythmia Agents Phase 4
31 Central Nervous System Depressants Phase 4,Phase 2
32
Serotonin Investigational, Nutraceutical Phase 4,Phase 2,Not Applicable 50-67-9 5202
33 Anticonvulsants Phase 3,Not Applicable
34
Buspirone Approved, Investigational Phase 2 36505-84-7 2477
35 Naluzotan Investigational Phase 2 740873-06-7
36 Serotonin Receptor Agonists Phase 2,Not Applicable
37 Anti-Anxiety Agents Phase 2
38 Serotonin 5-HT1 Receptor Agonists Phase 2
39
Sertraline Approved Not Applicable 79617-96-2 68617
40
Memantine Approved, Investigational Not Applicable 19982-08-2 4054
41
Dopamine Approved Not Applicable 62-31-7, 51-61-6 681
42
Glutamic Acid Approved, Nutraceutical 56-86-0 33032
43 Immunologic Factors Not Applicable
44 Fluorodeoxyglucose F18
45 Fluorides
46 Dopamine Agents Not Applicable
47 Excitatory Amino Acid Antagonists Not Applicable
48 Excitatory Amino Acids Not Applicable
49 polysaccharide-K

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy Completed NCT00595699 Phase 4 escitalopram;placebo
2 Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines Enrolling by invitation NCT02090998 Phase 4 Amitriptyline
3 Early Surgical Intervention to Treat Epilepsy Completed NCT00040326 Phase 3 antiepileptic drugs
4 A Multicenter Study of Hippocampal Electrical Stimulation (HS, in Mesial Temporal Lobe Epilepsy Terminated NCT00717431 Phase 3
5 Buspirone Therapy for Localized Epilepsy Terminated NCT01496612 Phase 2 Buspirone
6 PRX-00023 Therapy in Localization-Related Epilepsy Terminated NCT01281956 Phase 2 PRX-00023;Placebo
7 Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy Completed NCT00916266 Phase 1
8 Efficacy of TDCS for Treating Working Memory Dysfunction and Depression in Temporal Lobe Epilepsy Withdrawn NCT02268578 Phase 1
9 Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE) Unknown status NCT02383407 Not Applicable
10 Controlled Randomized Vagus Nerve Stimulation (VNS) Therapy Versus Resection (CoRaVNStiR) Unknown status NCT02089243 Not Applicable
11 Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery Unknown status NCT02590419 Not Applicable
12 Controlled Randomized Stimulation Versus Resection (CoRaStiR) Unknown status NCT00431457 Not Applicable
13 Emotional Processing and Memory Evaluation in Epilepsy Patients Unknown status NCT00486239 Early Phase 1
14 Near Death Experience (NDE) and Migraine Unknown status NCT02854930
15 Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy Completed NCT01563627 Not Applicable
16 Study of [11C]DPA-713 for Temporal Lobe Epilepsy Completed NCT01793532
17 CBT Versus Selective Serotonin Reuptake Inhibitor For Treatment Of Depression In Temporal Lobe Epilepsy Patients Completed NCT02262156 Not Applicable SSRI
18 Language and Emotional Function in Patients With Temporal Lobe Epilepsy Completed NCT00081432
19 GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression Completed NCT00931619
20 Radiosurgery or Open Surgery for Epilepsy Trial Completed NCT00860145 Not Applicable
21 Electrical Brain Stimulation to Reduce Epileptic Seizures Completed NCT00344877
22 Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy Completed NCT01772654 Not Applicable
23 Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery Completed NCT03102957 Not Applicable
24 Does Memantine Improve Verbal Memory Task Performance in Subjects With Partial Epilepsy and Memory Dysfunction? Completed NCT01054599 Not Applicable Memantine;Memantine
25 Neocortical Epilepsies - Do They Progress? Completed NCT00610558 Not Applicable
26 Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery Completed NCT01285921 Not Applicable
27 Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy Completed NCT00001672
28 Brain P-gp and Inflammation in People With Epilepsy Completed NCT01663545
29 Light Scattering Spectroscopy to Determine Brain Tumors Completed NCT00067418
30 fMRI Guided TMS Enhancement of Associative Memory Networks Completed NCT02749422 Not Applicable
31 Language Mapping in Patients With Epilepsy Completed NCT00706160
32 Brain Network Activation Analysis in Epilepsy Completed NCT03265925
33 Advanced Magnetic Resonance Imaging in Temporal Lobe Epilepsy Recruiting NCT03643471
34 Stereotactic Laser Ablation for Temporal Lobe Epilepsy Recruiting NCT02844465 Not Applicable
35 Effects of tDCS on Depressive Symptoms of Participants With Temporal Lobe Epilepsy Recruiting NCT03871842 Not Applicable
36 Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe Epilepsy Recruiting NCT02151175 Not Applicable
37 Evaluation of Stress Sensitivity and Hyperemotivity in Epilepsy Compared to and a Group of Healthy Volunteers Recruiting NCT03464370 Not Applicable
38 COMETE Study : COgnitive Rehabilitation of MEmory in Temporal Epilepsy Recruiting NCT02589470 Not Applicable
39 Low Intensity Focused Ultrasound Treatment for Drug-Resistant Epilepsy: An Efficacy Trial Recruiting NCT03868293 Not Applicable
40 Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation Recruiting NCT02339376 Not Applicable
41 Emotion Recognition in Benign Epilepsy of Childhood With Centro-Temporal Spikes (BECTS) Recruiting NCT03465566
42 Surgery as a Treatment for Medically Intractable Epilepsy Recruiting NCT01273129
43 Investigating Epilepsy: Screening, Evaluation and Treatment Recruiting NCT03478852
44 Subcutaneous EEG in Epilepsy Active, not recruiting NCT02946151 Not Applicable
45 Feasibility Study on LITT for Medical Refractory Epilepsy Active, not recruiting NCT02820740 Not Applicable
46 Focused Ultrasound Neuromodulation for Treatment of Temporal Lobe Epilepsy Not yet recruiting NCT03657056 Not Applicable
47 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Terminated NCT02796287 Not Applicable
48 Evaluation and Treatment of Patients With Epilepsy Terminated NCT00013845
49 The Utility of NIOM During LITT for Refractory MTLE Withdrawn NCT02913742 Not Applicable
50 Efficacy and Safety of the Use of Memantine for Preserving Cognition in Adult Patients With Epilepsy Withdrawn NCT00986115 Not Applicable Memantine;Placebo

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: epilepsy, temporal lobe

Genetic Tests for Temporal Lobe Epilepsy

Anatomical Context for Temporal Lobe Epilepsy

MalaCards organs/tissues related to Temporal Lobe Epilepsy:

42
Temporal Lobe, Brain, Amygdala, Cortex, Testes, Bone, Bone Marrow

Publications for Temporal Lobe Epilepsy

Articles related to Temporal Lobe Epilepsy:

(show top 50) (show all 3195)
# Title Authors Year
1
Frontal lobe dysfunction as a predictor of depression and anxiety following temporal lobe epilepsy surgery. ( 30909053 )
2019
2
Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: A multiple case-study. ( 30870707 )
2019
3
LncRNA FTX inhibits hippocampal neuron apoptosis by regulating miR-21-5p/SOX7 axis in a rat model of temporal lobe epilepsy. ( 30871773 )
2019
4
Corrigendum to "Simultaneous scalp EEG improves seizure lateralization during unilateral intracranial EEG evaluation in temporal lobe epilepsy" [Seizure 64 January (2019) 8-15]. ( 30878309 )
2019
5
Inhibition of ferroptosis processes ameliorates cognitive impairment in kainic acid-induced temporal lobe epilepsy in rats. ( 30899387 )
2019
6
Burr Hole Microsurgery for Intracranial Tumors and Mesial Temporal Lobe Epilepsy: Results of 200 consecutive operations. ( 30902775 )
2019
7
REST/NRSF transcription factor is overexpressed in hippocampus of patients with drug-resistant mesial temporal lobe epilepsy. ( 30903955 )
2019
8
Default mode network deactivation in pediatric temporal lobe epilepsy: Relationship to a working memory task and executive function tests. ( 30909075 )
2019
9
Association Between Quantitative Electroencephalogram Frequency Composition and Post-Surgical Evolution in Pharmacoresistant Temporal Lobe Epilepsy Patients. ( 30836608 )
2019
10
From DREADD to Treatment in Temporal Lobe Epilepsy. ( 30838921 )
2019
11
Increased expression of DOC2A in human and rat temporal lobe epilepsy. ( 30844661 )
2019
12
Smad Anchor for Receptor Activation and Phospho-Smad3 Were Upregulated in Patients with Temporal Lobe Epilepsy. ( 30847724 )
2019
13
Association of Piriform Cortex Resection With Surgical Outcomes in Patients With Temporal Lobe Epilepsy. ( 30855662 )
2019
14
Expression of Nav1.5 in the pathogenesis of temporal lobe epilepsy. ( 30860472 )
2019
15
Proportional loss of parvalbumin-immunoreactive synaptic boutons and granule cells from the hippocampus of sea lions with temporal lobe epilepsy. ( 30861128 )
2019
16
Spatiotemporal expression and inhibition of prolyl oligopeptidase contradict its involvement in key pathologic mechanisms of kainic acid-induced temporal lobe epilepsy in rats. ( 30868119 )
2019
17
Development of temporal lobe epilepsy during maintenance electroconvulsive therapy: A case of human kindling? ( 30868132 )
2019
18
Commentary on Schotte et al. "Development of temporal lobe epilepsy during maintenance electroconvulsive therapy: A case of human kindling?" ( 30868133 )
2019
19
White matter correlates of disease duration in patients with temporal lobe epilepsy: updated review of literature. ( 30868482 )
2019
20
Impaired prefrontal cortex-thalamus pathway in intractable temporal lobe epilepsy with aberrant executive control function: MRI evidence. ( 30771725 )
2019
21
Large-Scale 3-5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy. ( 30783615 )
2019
22
The MicroRNA Expression Profiles of Human Temporal Lobe Epilepsy in HS ILAE Type 1. ( 30790096 )
2019
23
Transplanting GABAergic Neurons Differentiated from NSCs into Hippocampus Inhibits Seizures and Epileptiform Discharges in Pilocarpine-Induced Temporal Lobe Epilepsy Model. ( 30790741 )
2019
24
Letter to the Editor. Temporal lobe epilepsy: open or stereotactic surgery? ( 30797194 )
2019
25
Reassessing the impact of intraoperative electrocorticography on postoperative outcome of patients undergoing standard temporal lobectomy for MRI-negative temporal lobe epilepsy. ( 30797216 )
2019
26
In vivo measurement of brain network connectivity reflects progression and intrinsic disease severity in a model of temporal lobe epilepsy. ( 30798008 )
2019
27
Using low-frequency oscillations to detect temporal lobe epilepsy with machine learning. ( 30803273 )
2019
28
Baicalein improves cognitive deficits and hippocampus impairments in temporal lobe epilepsy rats. ( 30817901 )
2019
29
JNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy. ( 30685843 )
2019
30
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy. ( 30703372 )
2019
31
The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy. ( 30707894 )
2019
32
Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy. ( 30733834 )
2019
33
Altered upright face recognition and presence of face inversion effect in temporal lobe epilepsy: An event-related potential study. ( 30734399 )
2019
34
Machine learning identifies "rsfMRI epilepsy networks" in temporal lobe epilepsy. ( 30734849 )
2019
35
fMRI prediction of naming change after adult temporal lobe epilepsy surgery: Activation matters. ( 30740666 )
2019
36
Autosomal dominant temporal lobe epilepsy associated with heterozygous reelin mutation: 3 T brain MRI study with advanced neuroimaging methods. ( 30619712 )
2019
37
Human and rodent temporal lobe epilepsy is characterized by changes in O-GlcNAc homeostasis that can be reversed to dampen epileptiform activity. ( 30625365 )
2019
38
The validation of Short Interspersed Nuclear Elements (SINEs) as a RT-qPCR normalization strategy in a rodent model for temporal lobe epilepsy. ( 30629669 )
2019
39
Chronobiology of limbic seizures: Potential mechanisms and prospects of chronotherapy for mesial temporal lobe epilepsy. ( 30629979 )
2019
40
White matter microstructural differences between right and left mesial temporal lobe epilepsy. ( 30635771 )
2019
41
Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy. ( 30642762 )
2019
42
Real-time effects of interictal spikes on hippocampus and amygdala functional connectivity in unilateral temporal lobe epilepsy: An EEG-fMRI study. ( 30653664 )
2019
43
Hemispheric Regional Based Analysis of Diffusion Tensor Imaging and Diffusion Tensor Tractography in Patients with Temporal Lobe Epilepsy and Correlation with Patient outcomes. ( 30659215 )
2019
44
Structural and functional asymmetry of medial temporal subregions in unilateral temporal lobe epilepsy: A 7T MRI study. ( 30666753 )
2019
45
Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population. ( 30669988 )
2019
46
Glia activation of eukaryotic translation initiation factor 4e-binding protein 1 in temporal lobe epilepsy. ( 30672889 )
2019
47
Transient seizure onset network for localization of epileptogenic zone: effective connectivity and graph theory-based analyses of ECoG data in temporal lobe epilepsy. ( 30684208 )
2019
48
Cognitive impairment and drug responsiveness in mesial temporal lobe epilepsy. ( 30576963 )
2019
49
Normal cerebral cortical thickness in first-degree relatives of temporal lobe epilepsy patients. ( 30587513 )
2019
50
Disruption of functional connectivity among subcortical arousal system and cortical networks in temporal lobe epilepsy. ( 30617780 )
2019

Variations for Temporal Lobe Epilepsy

Expression for Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for Temporal Lobe Epilepsy

Pathways related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.39 GABBR1 GABBR2 GRIK1 GRIN1 HTR1A NPY
2
Show member pathways
12.8 GABBR1 GABBR2 GRIK1 GRIN1 SLC1A2 SLC1A3
3
Show member pathways
12.72 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 SLC1A2
4 11.95 BDNF GRIN1 HTR1A SLC1A3
5 11.86 GABBR1 GABBR2 GAD1 GFAP GRIN1 HTR1A
6
Show member pathways
11.82 GABBR1 GABBR2 HTR1A
7
Show member pathways
11.79 BDNF GRIN1 PDYN
8
Show member pathways
11.77 GRIN1 SLC1A2 SLC1A3
9 11.76 BDNF GABBR1 GABBR2 GRIN1 HTR1A NPY
10 11.75 BDNF GFAP GRIN1 PDYN
11 11.46 BDNF GAD1 GFAP SLC1A3
12 11.45 BDNF GAD1 GRIN1
13 11.23 BDNF GABBR1 GABBR2
14 10.73 GABBR1 GABBR2
15 10.56 GABBR1 GABBR2 GAD1
16
Show member pathways
10.4 SLC1A2 SLC1A3

GO Terms for Temporal Lobe Epilepsy

Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 GABBR1 GABBR2 GRIK1 GRIN1 HTR1A SLC1A2
2 cell junction GO:0030054 9.73 GABBR1 GABBR2 GRIK1 GRIN1 LGI1 SV2B
3 synaptic vesicle GO:0008021 9.63 BDNF GRIN1 SV2B
4 postsynaptic membrane GO:0045211 9.62 GABBR1 GABBR2 GRIK1 GRIN1
5 dendrite GO:0030425 9.43 BDNF GABBR1 GRIN1 HTR1A PDYN RELN
6 synaptic cleft GO:0043083 9.4 GRIN1 LGI1
7 synapse GO:0045202 9.17 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 LGI1
8 G protein-coupled receptor heterodimeric complex GO:0038039 9.16 GABBR1 GABBR2
9 plasma membrane GO:0005886 10.21 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 HTR1A

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.85 GAD1 SLC1A2 SLC1A3 TSPO
2 ion transport GO:0006811 9.73 GRIK1 GRIN1 SCN1B SLC1A2 SLC1A3 TSPO
3 axon guidance GO:0007411 9.71 BDNF LGI1 RELN SCN1B
4 response to wounding GO:0009611 9.63 GFAP SLC1A2 SLC1A3
5 cerebral cortex development GO:0021987 9.61 GRIN1 NPY RELN
6 ionotropic glutamate receptor signaling pathway GO:0035235 9.58 GRIK1 GRIN1
7 positive regulation of synaptic transmission GO:0050806 9.57 LGI1 SLC1A3
8 response to pain GO:0048265 9.56 RELN TSPO
9 negative regulation of adenylate cyclase activity GO:0007194 9.54 GABBR1 GABBR2
10 modulation of chemical synaptic transmission GO:0050804 9.54 BDNF GRIK1 RELN
11 glutamate secretion GO:0014047 9.52 SLC1A2 SLC1A3
12 positive regulation of glial cell proliferation GO:0060252 9.51 GFAP TSPO
13 L-glutamate transmembrane transport GO:0015813 9.49 SLC1A2 SLC1A3
14 regulation of behavior GO:0050795 9.48 HTR1A RELN
15 L-glutamate import across plasma membrane GO:0098712 9.32 SLC1A2 SLC1A3
16 chemical synaptic transmission GO:0007268 9.32 GABBR2 GAD1 GRIK1 HTR1A NPY PDYN
17 D-aspartate import across plasma membrane GO:0070779 9.16 SLC1A2 SLC1A3
18 gamma-aminobutyric acid biosynthetic process GO:0009449 8.96 GAD1 SLC1A3

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 L-glutamate transmembrane transporter activity GO:0005313 9.32 SLC1A2 SLC1A3
2 high-affinity glutamate transmembrane transporter activity GO:0005314 9.26 SLC1A2 SLC1A3
3 G protein-coupled GABA receptor activity GO:0004965 9.16 GABBR1 GABBR2
4 glutamate:sodium symporter activity GO:0015501 8.96 SLC1A2 SLC1A3
5 glutamate binding GO:0016595 8.8 GAD1 GRIN1 SLC1A3

Sources for Temporal Lobe Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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