MCID: TMP001
MIFTS: 58

Temporal Lobe Epilepsy

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Temporal Lobe Epilepsy

MalaCards integrated aliases for Temporal Lobe Epilepsy:

Name: Temporal Lobe Epilepsy 39 12 15 17
Epilepsy, Temporal Lobe 12 45 74
Epilepsy Temporal Lobe 56

Classifications:



External Ids:

Disease Ontology 12 DOID:3328
MeSH 45 D004833
SNOMED-CT 69 84340007
UMLS 74 C0014556

Summaries for Temporal Lobe Epilepsy

MalaCards based summary : Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to epilepsy, familial temporal lobe, 1 and autosomal dominant epilepsy with auditory features, and has symptoms including seizures An important gene associated with Temporal Lobe Epilepsy is ADARB2-AS1 (ADARB2 Antisense RNA 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Circadian entrainment. The drugs Citalopram and Amitriptyline have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and amygdala, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 77 Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system characterized by recurrent,... more...

Related Diseases for Temporal Lobe Epilepsy

Diseases in the Temporal Lobe Epilepsy family:

Epilepsy, Familial Temporal Lobe, 1 Epilepsy, Familial Temporal Lobe, 2
Epilepsy, Familial Temporal Lobe, 3 Epilepsy, Familial Temporal Lobe, 4
Epilepsy, Familial Temporal Lobe, 5 Epilepsy, Familial Temporal Lobe, 6
Epilepsy, Familial Temporal Lobe, 7 Epilepsy, Familial Temporal Lobe, 8

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 epilepsy, familial temporal lobe, 1 34.0 LGI1 RELN
2 autosomal dominant epilepsy with auditory features 32.8 LGI1 RELN
3 epilepsy 32.4 BDNF GABBR1 GAD1 LGI1 RELN SCN1B
4 depression 31.6 BDNF HTR1A RELN
5 status epilepticus 31.4 BDNF GFAP LGI1 NPY
6 anxiety 31.1 BDNF HTR1A NPY TSPO
7 encephalitis 31.0 GFAP LGI1 TSPO
8 mood disorder 30.7 BDNF HTR1A NPY
9 obsessive-compulsive disorder 30.7 BDNF HTR1A PDYN
10 amnestic disorder 30.6 BDNF HTR1A LGI1 PDYN TSPO
11 major depressive disorder 30.6 BDNF GAD1 HTR1A NPY
12 dysembryoplastic neuroepithelial tumor 30.6 GFAP GRIN1
13 psychotic disorder 30.5 BDNF HTR1A RELN
14 epilepsy, idiopathic generalized 30.4 GABBR1 LGI1 SCN1B TSPO
15 bipolar disorder 30.4 BDNF GAD1 HTR1A RELN
16 focal epilepsy 30.3 LGI1 PDYN TSPO
17 childhood absence epilepsy 30.0 GABBR1 GRIK1 SCN1B
18 autism 29.8 BDNF GAD1 HTR1A RELN
19 schizophrenia 29.7 BDNF GABBR1 GAD1 GRIK1 GRIN1 HTR1A
20 mesial temporal lobe epilepsy with hippocampal sclerosis 12.6
21 benign familial mesial temporal lobe epilepsy 12.4
22 infantile-onset mesial temporal lobe epilepsy with severe cognitive regression 12.4
23 epilepsy, familial temporal lobe, 2 12.4
24 epilepsy, familial temporal lobe, 3 12.4
25 epilepsy, familial temporal lobe, 5 12.1
26 epilepsy, familial temporal lobe, 8 12.1
27 epilepsy, familial temporal lobe, 7 12.1
28 epilepsy, familial temporal lobe, 4 12.0
29 epilepsy, familial temporal lobe, 6 11.9
30 autosomal dominant partial epilepsy with auditory features 11.9
31 temporal epilepsy, familial 11.7
32 febrile seizures, familial, 11 11.7
33 epilepsy, familial focal, with variable foci 2 11.4
34 epilepsy, familial focal, with variable foci 3 11.4
35 lipoid proteinosis of urbach and wiethe 11.3
36 epilepsy, nocturnal frontal lobe, 1 11.3
37 mental retardation, anterior maxillary protrusion, and strabismus 11.3
38 epilepsy, familial focal, with variable foci 4 11.3
39 seizure disorder 10.7
40 febrile seizures 10.6
41 cysticercosis 10.5
42 dissociative amnesia 10.4 HTR1A PDYN
43 suppression amblyopia 10.4 GABBR1 GRIN1
44 neonatal hypoxic and ischemic brain injury 10.4 BDNF SLC1A3
45 childhood disintegrative disease 10.4 BDNF LGI1
46 generalized anxiety disorder 10.3 BDNF HTR1A TSPO
47 endogenous depression 10.3 BDNF HTR1A NPY
48 syncope 10.3
49 spinal cord injury 10.3 BDNF GFAP PDYN
50 toxic encephalopathy 10.3 BDNF GFAP SLC1A2

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to Temporal Lobe Epilepsy

Symptoms & Phenotypes for Temporal Lobe Epilepsy

UMLS symptoms related to Temporal Lobe Epilepsy:


seizures

MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 BDNF GABBR1 GABBR2 GAD1 GFAP GRIK1
2 growth/size/body region MP:0005378 10.28 BDNF GABBR1 GABBR2 GAD1 GFAP GRIK1
3 mortality/aging MP:0010768 10.17 BDNF GABBR1 GABBR2 GAD1 GFAP GRIN1
4 nervous system MP:0003631 10.16 BDNF GABBR1 GABBR2 GAD1 GFAP GRIK1
5 homeostasis/metabolism MP:0005376 10.15 BDNF GABBR1 GABBR2 GAD1 GFAP GRIN1
6 no phenotypic analysis MP:0003012 9.7 BDNF GAD1 GRIN1 HTR1A PDYN SCN1B
7 normal MP:0002873 9.65 BDNF GAD1 GFAP GRIK1 GRIN1 NPY
8 vision/eye MP:0005391 9.23 BDNF GFAP GRIN1 LGI1 RELN SCN1B

Drugs & Therapeutics for Temporal Lobe Epilepsy

Drugs for Temporal Lobe Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4,Not Applicable 59729-33-8 2771
2
Amitriptyline Approved Phase 4 50-48-6 2160
3
Perphenazine Approved Phase 4 58-39-9 4748
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5 Parasympatholytics Phase 4
6 Antidepressive Agents Phase 4,Not Applicable
7 Neurotransmitter Uptake Inhibitors Phase 4,Not Applicable
8 Peripheral Nervous System Agents Phase 4
9 Antiparkinson Agents Phase 4,Not Applicable
10 Cholinergic Agents Phase 4
11 Cholinergic Antagonists Phase 4
12 Antidepressive Agents, Second-Generation Phase 4
13 Autonomic Agents Phase 4
14 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
15 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
16 Serotonin Agents Phase 4,Phase 2,Not Applicable
17 Serotonin Uptake Inhibitors Phase 4,Not Applicable
18 Muscarinic Antagonists Phase 4
19 Anesthetics Phase 4,Not Applicable
20 Antidepressive Agents, Tricyclic Phase 4
21 Diuretics, Potassium Sparing Phase 4
22 Analgesics, Non-Narcotic Phase 4
23 Tranquilizing Agents Phase 4,Phase 2
24 Adrenergic Agents Phase 4
25 Analgesics Phase 4
26 Amitriptyline, perphenazine drug combination Phase 4
27 Antipsychotic Agents Phase 4
28 Anesthetics, Local Phase 4
29 Sodium Channel Blockers Phase 4
30 Anti-Arrhythmia Agents Phase 4
31 Central Nervous System Depressants Phase 4,Phase 2
32
Serotonin Investigational, Nutraceutical Phase 4,Phase 2,Not Applicable 50-67-9 5202
33 Anticonvulsants Phase 3,Not Applicable
34
Buspirone Approved, Investigational Phase 2 36505-84-7 2477
35 Naluzotan Investigational Phase 2 740873-06-7
36 Serotonin Receptor Agonists Phase 2,Not Applicable
37 Anti-Anxiety Agents Phase 2
38 Serotonin 5-HT1 Receptor Agonists Phase 2
39
Sertraline Approved Not Applicable 79617-96-2 68617
40
Memantine Approved, Investigational Not Applicable 19982-08-2 4054
41
Dopamine Approved Not Applicable 62-31-7, 51-61-6 681
42
Glutamic Acid Approved, Nutraceutical 56-86-0 33032
43 Immunologic Factors Not Applicable
44 Fluorodeoxyglucose F18
45 Fluorides
46 Dopamine Agents Not Applicable
47 Excitatory Amino Acid Antagonists Not Applicable
48 Excitatory Amino Acids Not Applicable
49 polysaccharide-K

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy Completed NCT00595699 Phase 4 escitalopram;placebo
2 Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines Enrolling by invitation NCT02090998 Phase 4 Amitriptyline
3 Early Surgical Intervention to Treat Epilepsy Completed NCT00040326 Phase 3 antiepileptic drugs
4 A Multicenter Study of Hippocampal Electrical Stimulation (HS, in Mesial Temporal Lobe Epilepsy Terminated NCT00717431 Phase 3
5 Buspirone Therapy for Localized Epilepsy Terminated NCT01496612 Phase 2 Buspirone
6 PRX-00023 Therapy in Localization-Related Epilepsy Terminated NCT01281956 Phase 2 PRX-00023;Placebo
7 Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy Completed NCT00916266 Phase 1
8 Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy Recruiting NCT03946618 Phase 1
9 Efficacy of TDCS for Treating Working Memory Dysfunction and Depression in Temporal Lobe Epilepsy Withdrawn NCT02268578 Phase 1
10 Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE) Unknown status NCT02383407 Not Applicable
11 Controlled Randomized Vagus Nerve Stimulation (VNS) Therapy Versus Resection (CoRaVNStiR) Unknown status NCT02089243 Not Applicable
12 Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery Unknown status NCT02590419 Not Applicable
13 Controlled Randomized Stimulation Versus Resection (CoRaStiR) Unknown status NCT00431457 Not Applicable
14 Emotional Processing and Memory Evaluation in Epilepsy Patients Unknown status NCT00486239 Early Phase 1
15 Near Death Experience (NDE) and Migraine Unknown status NCT02854930
16 Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy Completed NCT01563627 Not Applicable
17 Study of [11C]DPA-713 for Temporal Lobe Epilepsy Completed NCT01793532
18 CBT Versus Selective Serotonin Reuptake Inhibitor For Treatment Of Depression In Temporal Lobe Epilepsy Patients Completed NCT02262156 Not Applicable SSRI
19 Language and Emotional Function in Patients With Temporal Lobe Epilepsy Completed NCT00081432
20 GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression Completed NCT00931619
21 Radiosurgery or Open Surgery for Epilepsy Trial Completed NCT00860145 Not Applicable
22 Electrical Brain Stimulation to Reduce Epileptic Seizures Completed NCT00344877
23 Subcutaneous EEG in Epilepsy Completed NCT02946151 Not Applicable
24 Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy Completed NCT01772654 Not Applicable
25 Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery Completed NCT03102957 Not Applicable
26 Does Memantine Improve Verbal Memory Task Performance in Subjects With Partial Epilepsy and Memory Dysfunction? Completed NCT01054599 Not Applicable Memantine;Memantine
27 Neocortical Epilepsies - Do They Progress? Completed NCT00610558 Not Applicable
28 Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery Completed NCT01285921 Not Applicable
29 Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy Completed NCT00001672
30 Brain P-gp and Inflammation in People With Epilepsy Completed NCT01663545
31 Light Scattering Spectroscopy to Determine Brain Tumors Completed NCT00067418
32 Language Mapping in Patients With Epilepsy Completed NCT00706160
33 Brain Network Activation Analysis in Epilepsy Completed NCT03265925
34 Advanced Magnetic Resonance Imaging in Temporal Lobe Epilepsy Recruiting NCT03643471
35 Stereotactic Laser Ablation for Temporal Lobe Epilepsy Recruiting NCT02844465 Not Applicable
36 Effects of tDCS on Depressive Symptoms of Participants With Temporal Lobe Epilepsy Recruiting NCT03871842 Not Applicable
37 Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe Epilepsy Recruiting NCT02151175 Not Applicable
38 Evaluation of Stress Sensitivity and Hyperemotivity in Epilepsy Compared to and a Group of Healthy Volunteers Recruiting NCT03464370 Not Applicable
39 COMETE Study : COgnitive Rehabilitation of MEmory in Temporal Epilepsy Recruiting NCT02589470 Not Applicable
40 Low Intensity Focused Ultrasound Treatment for Drug-Resistant Epilepsy: An Efficacy Trial Recruiting NCT03868293 Not Applicable
41 Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation Recruiting NCT02339376 Not Applicable
42 Emotion Recognition in Benign Epilepsy of Childhood With Centro-Temporal Spikes (BECTS) Recruiting NCT03465566
43 Surgery as a Treatment for Medically Intractable Epilepsy Recruiting NCT01273129
44 Investigating Epilepsy: Screening, Evaluation and Treatment Recruiting NCT03478852
45 Feasibility Study on LITT for Medical Refractory Epilepsy Active, not recruiting NCT02820740 Not Applicable
46 fMRI Guided TMS Enhancement of Associative Memory Networks Active, not recruiting NCT02749422 Not Applicable
47 Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation Enrolling by invitation NCT03958903 Not Applicable
48 Focused Ultrasound Neuromodulation for Treatment of Temporal Lobe Epilepsy Not yet recruiting NCT03657056 Not Applicable
49 SEEG Guided RF-TC v.s. ATL for mTLE With HS Not yet recruiting NCT03941613 Not Applicable
50 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Terminated NCT02796287 Not Applicable

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: epilepsy, temporal lobe

Genetic Tests for Temporal Lobe Epilepsy

Anatomical Context for Temporal Lobe Epilepsy

MalaCards organs/tissues related to Temporal Lobe Epilepsy:

42
Temporal Lobe, Brain, Amygdala, Cortex, Testes, Bone Marrow, Thalamus

Publications for Temporal Lobe Epilepsy

Articles related to Temporal Lobe Epilepsy:

(show top 50) (show all 3224)
# Title Authors Year
1
Alteration of GABAergic signaling is associated with anxiety-like behavior in temporal lobe epilepsy mice. ( 30951784 )
2019
2
Frontal lobe dysfunction as a predictor of depression and anxiety following temporal lobe epilepsy surgery. ( 30909053 )
2019
3
Hospital Anxiety and Depression Scale-Anxiety subscale (HADS-A) and The State-Trait Anxiety Inventory (STAI) accuracy for anxiety disorders detection in drug-resistant mesial temporal lobe epilepsy patients. ( 30599368 )
2019
4
Association of temporal lobe epilepsy with gambling disorder in a patient with mild intellectual disability and autism spectrum disorder. ( 30953956 )
2019
5
Molecular expression and functional analysis of genes in children with temporal lobe epilepsy. ( 31091851 )
2019
6
Hippocampal involvement in nonpathological déjà vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent. ( 31094080 )
2019
7
Symptomatogenic zone and network of oroalimentary automatisms in mesial temporal lobe epilepsy. ( 31095733 )
2019
8
TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice. ( 31097691 )
2019
9
Hippocampal high frequency oscillations in unilateral and bilateral mesial temporal lobe epilepsy. ( 31100580 )
2019
10
Disruption and lateralization of cerebellar-cerebral functional networks in right temporal lobe epilepsy: A resting-state fMRI study. ( 31103016 )
2019
11
Effects of surgical targeting in laser interstitial thermal therapy for mesial temporal lobe epilepsy: A multicenter study of 234 patients. ( 31112302 )
2019
12
Neural response to stress and perceived stress differ in patients with left temporal lobe epilepsy. ( 31033120 )
2019
13
Restrained Dendritic Growth of Adult-Born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with Temporal Lobe Epilepsy. ( 31043461 )
2019
14
Comparing the Wada Test and Functional MRI for the Presurgical Evaluation of Memory in Temporal Lobe Epilepsy. ( 31044310 )
2019
15
Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence. ( 31059094 )
2019
16
Prediction of laterality in temporal lobe epilepsy using white matter diffusion metrics. ( 31059852 )
2019
17
Reduced Interhemispheric White Matter Asymmetries in Medial Temporal Lobe Epilepsy With Hippocampal Sclerosis. ( 31068889 )
2019
18
Temporal lobe epilepsy is associated with distinct cognitive phenotypes. ( 31077942 )
2019
19
Surgically treated intracranial supratentorial calcifying pseudoneoplasms of the neuraxis (CAPNON) with drug-resistant left temporal lobe epilepsy: A case report and review of the literature. ( 30963026 )
2019
20
Association of cerebrospinal fluid zinc-α2-glycoprotein and tau protein with temporal lobe epilepsy and related white matter impairment. ( 30964766 )
2019
21
Network and Pathway-Based Analysis of Single-Nucleotide Polymorphism of miRNA in Temporal Lobe Epilepsy. ( 30968344 )
2019
22
Low-Intensity Pulsed Ultrasound Stimulation Modulates the Nonlinear Dynamics of Local Field Potentials in Temporal Lobe Epilepsy. ( 31001072 )
2019
23
Similar and Differing Distributions Between 18F-FDG-PET and Arterial Spin Labeling Imaging in Temporal Lobe Epilepsy. ( 31001198 )
2019
24
Seizure control by low-intensity ultrasound in mice with temporal lobe epilepsy. ( 31002886 )
2019
25
Temporal lobe epilepsy: Hippocampal pathology modulates connectome topology and controllability. ( 31004070 )
2019
26
Construction and analysis of a dysregulated lncRNA-associated ceRNA network in a rat model of temporal lobe epilepsy. ( 31005697 )
2019
27
Resting fMRI as an alternative for task-based fMRI for language lateralization in temporal lobe epilepsy patients: a study using independent component analysis. ( 31020344 )
2019
28
Differential sensitivity of structural, diffusion, and resting-state functional MRI for detecting brain alterations and verbal memory impairment in temporal lobe epilepsy. ( 31020649 )
2019
29
Inhibition of ferroptosis processes ameliorates cognitive impairment in kainic acid-induced temporal lobe epilepsy in rats. ( 30899387 )
2019
30
Burr Hole Microsurgery for Intracranial Tumors and Mesial Temporal Lobe Epilepsy: Results of 200 Consecutive Operations. ( 30902775 )
2019
31
REST/NRSF transcription factor is overexpressed in hippocampus of patients with drug-resistant mesial temporal lobe epilepsy. ( 30903955 )
2019
32
Default mode network deactivation in pediatric temporal lobe epilepsy: Relationship to a working memory task and executive function tests. ( 30909075 )
2019
33
Cognitive phenotypes in temporal lobe epilepsy are associated with distinct patterns of white matter network abnormalities. ( 30918094 )
2019
34
Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy. ( 30927560 )
2019
35
Fast ripple analysis in human mesial temporal lobe epilepsy suggests two different seizure-generating mechanisms. ( 30928645 )
2019
36
Divergent network properties that predict early surgical failure versus late recurrence in temporal lobe epilepsy. ( 30952126 )
2019
37
Establishment of a novel mesial temporal lobe epilepsy rhesus monkey model via intra-hippocampal and intra-amygdala kainic acid injection assisted by neurosurgical robot system. ( 30954527 )
2019
38
Association of Piriform Cortex Resection With Surgical Outcomes in Patients With Temporal Lobe Epilepsy. ( 30855662 )
2019
39
Expression of Nav1.5 in the pathogenesis of temporal lobe epilepsy. ( 30860472 )
2019
40
Proportional loss of parvalbumin-immunoreactive synaptic boutons and granule cells from the hippocampus of sea lions with temporal lobe epilepsy. ( 30861128 )
2019
41
Spatiotemporal expression and inhibition of prolyl oligopeptidase contradict its involvement in key pathologic mechanisms of kainic acid-induced temporal lobe epilepsy in rats. ( 30868119 )
2019
42
Development of temporal lobe epilepsy during maintenance electroconvulsive therapy: A case of human kindling? ( 30868132 )
2019
43
Commentary on Schotte et al. "Development of temporal lobe epilepsy during maintenance electroconvulsive therapy: A case of human kindling?" ( 30868133 )
2019
44
White matter correlates of disease duration in patients with temporal lobe epilepsy: updated review of literature. ( 30868482 )
2019
45
Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: A multiple case-study. ( 30870707 )
2019
46
LncRNA FTX inhibits hippocampal neuron apoptosis by regulating miR-21-5p/SOX7 axis in a rat model of temporal lobe epilepsy. ( 30871773 )
2019
47
Corrigendum to "Simultaneous scalp EEG improves seizure lateralization during unilateral intracranial EEG evaluation in temporal lobe epilepsy" [Seizure 64 January (2019) 8-15]. ( 30878309 )
2019
48
The MicroRNA Expression Profiles of Human Temporal Lobe Epilepsy in HS ILAE Type 1. ( 30790096 )
2019
49
Transplanting GABAergic Neurons Differentiated from NSCs into Hippocampus Inhibits Seizures and Epileptiform Discharges in Pilocarpine-Induced Temporal Lobe Epilepsy Model. ( 30790741 )
2019
50
Letter to the Editor. Temporal lobe epilepsy: open or stereotactic surgery? ( 30797194 )
2019

Variations for Temporal Lobe Epilepsy

Expression for Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for Temporal Lobe Epilepsy

Pathways related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 GABBR1 GABBR2 GRIK1 GRIN1 HTR1A NPY
2
Show member pathways
12.8 GABBR1 GABBR2 GRIK1 GRIN1 SLC1A2 SLC1A3
3
Show member pathways
12.72 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 SLC1A2
4 11.95 BDNF GRIN1 HTR1A SLC1A3
5 11.86 GABBR1 GABBR2 GAD1 GFAP GRIN1 HTR1A
6
Show member pathways
11.81 GABBR1 GABBR2 HTR1A
7
Show member pathways
11.78 BDNF GRIN1 PDYN
8
Show member pathways
11.76 GRIN1 SLC1A2 SLC1A3
9 11.76 BDNF GABBR1 GABBR2 GRIN1 HTR1A NPY
10 11.75 BDNF GFAP GRIN1 PDYN
11 11.46 BDNF GAD1 GFAP SLC1A3
12 11.45 BDNF GAD1 GRIN1
13 11.23 BDNF GABBR1 GABBR2
14 10.71 GABBR1 GABBR2
15 10.56 GABBR1 GABBR2 GAD1

GO Terms for Temporal Lobe Epilepsy

Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 GABBR1 GABBR2 GRIK1 GRIN1 HTR1A SLC1A2
2 cell junction GO:0030054 9.73 GABBR1 GABBR2 GRIK1 GRIN1 LGI1 SV2B
3 synaptic vesicle GO:0008021 9.63 BDNF GRIN1 SV2B
4 postsynaptic membrane GO:0045211 9.62 GABBR1 GABBR2 GRIK1 GRIN1
5 dendrite GO:0030425 9.43 BDNF GABBR1 GRIN1 HTR1A PDYN RELN
6 synaptic cleft GO:0043083 9.4 GRIN1 LGI1
7 synapse GO:0045202 9.17 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 LGI1
8 G protein-coupled receptor heterodimeric complex GO:0038039 9.16 GABBR1 GABBR2
9 plasma membrane GO:0005886 10.21 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 HTR1A

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.85 GAD1 SLC1A2 SLC1A3 TSPO
2 ion transport GO:0006811 9.73 GRIK1 GRIN1 SCN1B SLC1A2 SLC1A3 TSPO
3 axon guidance GO:0007411 9.71 BDNF LGI1 RELN SCN1B
4 response to wounding GO:0009611 9.63 GFAP SLC1A2 SLC1A3
5 cerebral cortex development GO:0021987 9.61 GRIN1 NPY RELN
6 ionotropic glutamate receptor signaling pathway GO:0035235 9.58 GRIK1 GRIN1
7 positive regulation of synaptic transmission GO:0050806 9.57 LGI1 SLC1A3
8 response to pain GO:0048265 9.56 RELN TSPO
9 modulation of chemical synaptic transmission GO:0050804 9.54 BDNF GRIK1 RELN
10 glutamate secretion GO:0014047 9.52 SLC1A2 SLC1A3
11 positive regulation of glial cell proliferation GO:0060252 9.51 GFAP TSPO
12 L-glutamate transmembrane transport GO:0015813 9.49 SLC1A2 SLC1A3
13 regulation of behavior GO:0050795 9.48 HTR1A RELN
14 L-glutamate import across plasma membrane GO:0098712 9.32 SLC1A2 SLC1A3
15 chemical synaptic transmission GO:0007268 9.28 GABBR2 GAD1 GRIK1 HTR1A NPY PDYN
16 negative regulation of adenylate cyclase activity GO:0007194 9.24 GABBR2
17 D-aspartate import across plasma membrane GO:0070779 9.16 SLC1A2 SLC1A3
18 gamma-aminobutyric acid biosynthetic process GO:0009449 8.96 GAD1 SLC1A3

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 L-glutamate transmembrane transporter activity GO:0005313 9.32 SLC1A2 SLC1A3
2 high-affinity glutamate transmembrane transporter activity GO:0005314 9.26 SLC1A2 SLC1A3
3 G protein-coupled GABA receptor activity GO:0004965 9.16 GABBR1 GABBR2
4 glutamate:sodium symporter activity GO:0015501 8.96 SLC1A2 SLC1A3
5 glutamate binding GO:0016595 8.8 GAD1 GRIN1 SLC1A3

Sources for Temporal Lobe Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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