MCID: TMP001
MIFTS: 49

Temporal Lobe Epilepsy

Categories: Ear diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Temporal Lobe Epilepsy

MalaCards integrated aliases for Temporal Lobe Epilepsy:

Name: Temporal Lobe Epilepsy 12 15 37 17
Epilepsy, Temporal Lobe 12 44 70
Epilepsy Temporal Lobe 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3328
MeSH 44 D004833
SNOMED-CT 67 84340007
UMLS 70 C0014556

Summaries for Temporal Lobe Epilepsy

MalaCards based summary : Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to epilepsy, familial temporal lobe, 1 and epilepsy, familial temporal lobe, 7, and has symptoms including seizures An important gene associated with Temporal Lobe Epilepsy is ADARB2-AS1 (ADARB2 Antisense RNA 1), and among its related pathways/superpathways are Neuroscience and cAMP signaling pathway. The drugs Citalopram and Dexetimide have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, amygdala and cortex, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 73 Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system characterized by recurrent,... more...

Related Diseases for Temporal Lobe Epilepsy

Diseases in the Temporal Lobe Epilepsy family:

Epilepsy, Familial Temporal Lobe, 1 Epilepsy, Familial Temporal Lobe, 2
Epilepsy, Familial Temporal Lobe, 3 Epilepsy, Familial Temporal Lobe, 4
Epilepsy, Familial Temporal Lobe, 5 Epilepsy, Familial Temporal Lobe, 6
Epilepsy, Familial Temporal Lobe, 7 Epilepsy, Familial Temporal Lobe, 8

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 416)
# Related Disease Score Top Affiliating Genes
1 epilepsy, familial temporal lobe, 1 33.4 SCN1B RELN LGI1
2 epilepsy, familial temporal lobe, 7 33.2 RELN LGI1
3 epilepsy, familial temporal lobe, 5 32.9 SCN1B CPA6
4 autosomal dominant epilepsy with auditory features 32.7 RELN LGI1
5 focal epilepsy 32.2 TSPO PDYN LGI1 GRIN2A CPA6
6 status epilepticus 31.9 TSPO SLC1A2 PVALB NPY LGI1 GFAP
7 epilepsy 31.8 TSPO SV2B SLC1A2 SCN1B RELN PVALB
8 mood disorder 31.5 RELN NPY GFAP BDNF
9 amnestic disorder 31.5 TSPO PDYN LGI1 GRIN2A BDNF
10 ganglioglioma 31.5 SLC1A2 PVALB GFAP
11 psychotic disorder 31.3 RELN PVALB PDYN GRIN2A BDNF
12 traumatic brain injury 31.3 GFAP BDNF
13 major depressive disorder 31.2 SLC1A2 PVALB NPY GRIN2A BDNF
14 obsessive-compulsive disorder 31.1 PDYN NPY GRIN2A GABBR1 BDNF
15 anxiety 31.1 TSPO PDYN NPY GRIN2A GABBR1 BDNF
16 epilepsy, myoclonic juvenile 31.1 SCN1B PVALB LGI1 GABBR1 CPA6
17 epilepsy, idiopathic generalized 31.1 TSPO SCN1B PVALB LGI1 GRIN2A GABBR1
18 sleep disorder 31.0 PDYN NPY BDNF
19 dystonia 31.0 RELN PVALB PDYN NPY GRIN2A GABBR1
20 migraine with or without aura 1 31.0 SLC1A2 PDYN NPY BDNF
21 choreatic disease 30.9 PVALB LGI1 BDNF
22 encephalomalacia 30.9 SLC1A2 GFAP BDNF
23 retrograde amnesia 30.8 PDYN LGI1 BDNF
24 anterograde amnesia 30.8 TSPO LGI1 BDNF
25 west syndrome 30.7 SCN1B PVALB LGI1 GRIN2A
26 speech and communication disorders 30.7 LGI1 GRIN2A GFAP BDNF
27 substance abuse 30.7 PDYN NPY BDNF
28 bipolar disorder 30.6 TSPO SLC1A2 RELN PVALB PDYN GRIN2A
29 neonatal hypoxic and ischemic brain injury 30.6 PVALB BDNF
30 adjustment disorder 30.5 TSPO NPY BDNF
31 withdrawal disorder 30.5 TSPO PDYN NPY
32 leukoencephalopathy, hereditary diffuse, with spheroids 30.5 TSPO SLC1A2 PVALB GFAP CALB1
33 generalized anxiety disorder 30.5 TSPO NPY BDNF
34 gangliocytoma 30.4 PVALB GFAP
35 alcohol use disorder 30.4 GABBR2 GABBR1 BDNF
36 generalized epilepsy with febrile seizures plus 30.4 SCN1B PVALB LGI1
37 fragile x syndrome 30.4 PVALB GRIN2A GABBR1 BDNF
38 alzheimer disease 30.4 TSPO SLC1A2 RELN PVALB PDYN GRIN2A
39 schizophrenia 30.3 TSPO SLC1A2 RELN PVALB PDYN NPY
40 huntington disease 30.2 SLC1A2 PDYN NPY GRIN2A CALB1 BDNF
41 motor neuron disease 30.2 SLC1A2 PVALB CALB1 BDNF
42 amyotrophic lateral sclerosis 1 30.2 TSPO SLC1A2 PVALB GFAP CALB1 BDNF
43 childhood absence epilepsy 30.1 TSPO SLC1A2 SCN1B PVALB PDYN LGI1
44 autism 30.1 SLC1A2 RELN NPY GRIN2A GFAP GABBR2
45 epilepsy, familial temporal lobe, 2 11.8
46 mesial temporal lobe epilepsy with hippocampal sclerosis 11.7
47 epilepsy, familial temporal lobe, 3 11.7
48 epilepsy, familial temporal lobe, 6 11.6
49 epilepsy, familial temporal lobe, 8 11.6
50 epilepsy, familial temporal lobe, 4 11.6

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to Temporal Lobe Epilepsy

Symptoms & Phenotypes for Temporal Lobe Epilepsy

UMLS symptoms related to Temporal Lobe Epilepsy:


seizures

MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.16 ACOT7 BDNF CALB1 GABBR1 GABBR2 GFAP
2 growth/size/body region MP:0005378 9.97 ACOT7 BDNF GABBR1 GABBR2 GFAP LGI1
3 nervous system MP:0003631 9.83 ACOT7 BDNF CALB1 GABBR1 GABBR2 GFAP
4 normal MP:0002873 9.28 BDNF CALB1 GFAP NPY PVALB SCN1B

Drugs & Therapeutics for Temporal Lobe Epilepsy

Drugs for Temporal Lobe Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2
Dexetimide Withdrawn Phase 4 21888-98-2
3 Antidepressive Agents Phase 4
4 Serotonin Uptake Inhibitors Phase 4
5 Psychotropic Drugs Phase 4
6
Naluzotan Investigational Phase 2 740873-06-7
7 Serotonin Receptor Agonists Phase 2
8 Neurotransmitter Agents Phase 2
9 Serotonin 5-HT1 Receptor Agonists Phase 2
10
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202
11
Sertraline Approved 79617-96-2 68617
12
Glutamic acid Approved, Nutraceutical 56-86-0 33032
13 Fluorodeoxyglucose F18
14 Fluorides
15 Anesthetics
16 Anticonvulsants

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy. A Double-blind, Placebo-controlled Study. Completed NCT00595699 Phase 4 escitalopram;placebo
2 Hippocampal and Thalamic Deep Brain Stimulation for Bilateral Temporal Lobe Epilepsy Recruiting NCT04164056 Phase 4
3 Early Randomized Surgical Epilepsy Trial Completed NCT00040326 Phase 3 antiepileptic drugs
4 Medical vs Electrical Therapy for Temporal Lobe Epilepsy Terminated NCT00717431 Phase 3
5 A Phase II Clinical Trial of PRX-00023 Therapy in Localization-Related Epilepsy Terminated NCT01281956 Phase 2 PRX-00023;Placebo
6 Phase 1 Study of Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy Completed NCT00916266 Phase 1
7 Efficacy of Transcranial Direct Current Stimulation for Treating Working Memory Dysfunction and Depression For Patients With Temporal Lobe Epilepsy Withdrawn NCT02268578 Phase 1
8 Evaluation of Stress Sensitivity and Hyperemotivity in Temporal Lobe Epilepsy With Enlarged Amygdala Compared to Epilepsy Without Enlarged Amygdala (Temporal and Extra-temporal) and a Group of Healthy Volunteers: Pilot Study. Unknown status NCT03464370
9 Role of Advanced Magnetic Resonance Imaging in Diagnosis of Idiopathic Temporal Lobe Epilepsy Unknown status NCT03643471
10 Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE) Unknown status NCT02383407
11 Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery Unknown status NCT02590419
12 Study on the Safety and Effects of Transcranial Direct Current Stimulation (tDCS) in the Treatment of Depressive Symptoms in Participants With Temporal Lobe Epilepsy: A Randomized, Double-blind, Sham-controlled Clinical Trial Unknown status NCT03871842
13 Prospective Randomized Controlled Study of Neurostimulation in the Medial Temporal Lobe for Patients With Medically Refractory Medial Temporal Lobe Epilepsy; Controlled Randomized Stimulation Versus Resection (CoRaStiR) Unknown status NCT00431457
14 COMET Study Effectiveness of a Cognitive Remediation Program of Memory in Patients With Temporal Lobe Epilepsy Unknown status NCT02589470
15 Prospective Randomized Controlled Study of Vagus Nerve Stimulation Therapy in the Patients With Medically Refractory Medial Temporal Lobe Epilepsy; Controlled Randomized Vagus Nerve Stimulation Versus Resection (CoRaVNStiR) Unknown status NCT02089243
16 Symmetricity-Driven Learning Framework for Pediatric Temporal Lobe Epilepsy Detection Using 18F-FDG-PET Imaging Completed NCT04169581
17 Anticonvulsive Effects of Transcranial DC Stimulation in Pharmacoresistant Focal Epilepsy Completed NCT00344877
18 Subcutaneous EEG in Epilepsy - Proof of Concept and Clinical Applications Completed NCT02946151
19 Functional MRI (fMRI) and Diffusion Tensor Imaging (DTI) in Temporal Lobe Epilepsy Completed NCT00081432
20 Assessment of [11C]DPA-713 in Temporal Lobe Epilepsy Completed NCT01793532
21 Treatment Of Depression In Patients With Temporal Lobe Epilepsy: Comparative Study Of Cognitive Behavioral Therapy Vs. Selective Serotonin Reuptake Inhibitors Completed NCT02262156 SSRI
22 Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy: New Targets for Diagnosis and Prediction of Drug Resistance Completed NCT01563627
23 GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression Completed NCT00931619
24 Spectroscopic Determination of Brain Tumor Cells Completed NCT00067418
25 Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy Completed NCT00001672
26 Noninvasive Language Mapping in Patients With Localization-Related Epilepsy Completed NCT00706160
27 Brain Network Activation Analysis in Epilepsy Completed NCT03265925
28 Radiosurgery Versus Lobectomy for Temporal Lobe Epilepsy Completed NCT00860145
29 Stereotactic-EEG Guided Radio-frequency Thermocoagulation Versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy With Hippocampus Sclerosis Recruiting NCT03941613
30 LIFUP for Treatment of Temporal Lobe Epilepsy Recruiting NCT02151175
31 Stereotactic Laser Ablation for Temporal Lobe Epilepsy Recruiting NCT02844465
32 Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation Recruiting NCT02339376
33 Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics Recruiting NCT04649008 Early Phase 1
34 Investigating Epilepsy: Screening and Evaluation Recruiting NCT03478852
35 Surgery as a Treatment for Medically Intractable Epilepsy Recruiting NCT01273129
36 Epilepsy Surgery and Cognition, Psychiatric Function and Quality of Life - Outcome 10 Years or More After Surgery Enrolling by invitation NCT04264780
37 Electrophysiological Biomarkers During Invasive Monitoring of Mesial Temporal Lobe Epilepsy (MTLE) Patients Not yet recruiting NCT04710004
38 Focused Ultrasound Neuromodulation for Treatment of Temporal Lobe Epilepsy Not yet recruiting NCT03657056
39 Evaluation of the 24/7 EEG SubQ System for Ultra Long-Term Recording of Patients With Temporal Lobe Epilepsy An Open-label, Prospective, Paired, Comparative Study Not yet recruiting NCT04526418
40 Cognitive and Emotional Function and Brain Reorganisation Associated to Auditory Abilities : Impact of Tinnitus Not yet recruiting NCT04717388
41 A Prospective Study of the Utility of Neurophysiologic Intraoperative Monitoring by Stereotactic Depth Electrodes During MRI-guided Laser-interstitial Thermal Therapy for Refractory Mesial Temporal Lobe Epilepsy Withdrawn NCT02913742
42 Biomarkers in Neurodegenerative Diseases Withdrawn NCT04055532

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Mephenytoin
Phenytoin
Phenytoin sodium
PHENYTOIN SODIUM,EXTENDED
PHENYTOIN SODIUM,PROMPT

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: epilepsy, temporal lobe

Genetic Tests for Temporal Lobe Epilepsy

Anatomical Context for Temporal Lobe Epilepsy

MalaCards organs/tissues related to Temporal Lobe Epilepsy:

40
Temporal Lobe, Amygdala, Cortex, Brain, Bone Marrow, Thalamus, Eye

Publications for Temporal Lobe Epilepsy

Articles related to Temporal Lobe Epilepsy:

(show top 50) (show all 11085)
# Title Authors PMID Year
1
Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. 54 61
20437582 2010
2
Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families. 61 54
19780791 2010
3
Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. 54 61
19833108 2010
4
Conditional downregulation of brain- derived neurotrophic factor and tyrosine kinase receptor B blocks epileptogenesis in the human temporal lobe epilepsy hippocampus. 54 61
20228460 2010
5
Aberrant glutamate receptor 5 expression in temporal lobe epilepsy lesions. 54 61
19941835 2010
6
Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. 61 54
19864112 2010
7
The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study. 61 54
19747915 2009
8
Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy. 54 61
19437412 2009
9
[Expression and function of Cx32 and Cx43 junctions in medically intractable temporal lobe epilepsy in human]. 61 54
20137634 2009
10
Using cerebral white matter for estimation of nondisplaceable binding of 5-HT1A receptors in temporal lobe epilepsy. 61 54
19837769 2009
11
Positive correlation between the density of neuropeptide y positive neurons in the amygdala and parameters of self-reported anxiety and depression in mesiotemporal lobe epilepsy patients. 54 61
19482265 2009
12
Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy. 54 61
19287316 2009
13
Haploinsufficiency of glutamine synthetase increases susceptibility to experimental febrile seizures. 61 54
19170755 2009
14
Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP. 61 54
19038255 2009
15
Candidate genes for temporal lobe epilepsy: a replication study. 54 61
19066720 2008
16
[Aquaporin-4]. 61 54
19198125 2008
17
Association between the gamma-aminobutyric acid type B receptor 1 and 2 gene polymorphisms and mesial temporal lobe epilepsy in a Han Chinese population. 61 54
18653317 2008
18
GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: new evidence. 61 54
18255321 2008
19
M129V polymorphism in the prion protein gene is not associated with mesial temporal lobe epilepsy in a Han Chinese population. 54 61
18549399 2008
20
Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. 54 61
18509280 2008
21
Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. 54 61
18477594 2008
22
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain. 54 61
18394657 2008
23
Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. 54 61
18326497 2008
24
Analysis of LGI1 promoter sequence, PDYN and GABBR1 polymorphisms in sporadic and familial lateral temporal lobe epilepsy. 54 61
18355961 2008
25
Genetic etiology of new forms of familial epilepsy. 61 54
17981785 2008
26
Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy? 54 61
18226171 2008
27
Transcriptionally less active prodynorphin promoter alleles are associated with temporal lobe epilepsy: a case-control study and meta-analysis. 61 54
18334734 2008
28
5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression. 54 61
17588547 2007
29
The NR1 N-methyl-D-aspartate subunit and brain-derived neurotrophic factor in temporal lobe epilepsy hippocampus: a comparison of patients with and without coexisting psychiatric symptoms. 61 54
17919302 2007
30
Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. 54 61
17484754 2007
31
Limbic encephalitis with autoantibodies against the glutamate receptor epsilon 2 mimicking temporal lobe epilepsy. 61 54
17472608 2007
32
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. 54 61
17446080 2007
33
Seizure suppression by GDNF gene therapy in animal models of epilepsy. 54 61
17387333 2007
34
Association between the M129V variant allele of PRNP gene and mild temporal lobe epilepsy in women. 61 54
17092648 2007
35
Hippocampal Nogo-A and neo-Timm's staining in amygdala kindling rats. 54 61
17439704 2007
36
Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. 61 54
17020904 2007
37
Neuropeptide Y in the dentate gyrus. 54 61
17765725 2007
38
Potentiation of anti-epileptic drugs effectiveness by pyronaridine in refractory epilepsy. 54 61
17368747 2007
39
Viral risk factor for seizures: pathobiology of dynorphin in herpes simplex viral (HSV-1) seizures in an animal model. 54 61
16843674 2006
40
Syntaxin 1A promotes the endocytic sorting of EAAC1 leading to inhibition of glutamate transport. 61 54
16959903 2006
41
Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy. 54 61
16922873 2006
42
Architectural (Type IA) focal cortical dysplasia and parvalbumin immunostaining in temporal lobe epilepsy. 54 61
16822257 2006
43
Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease. 61 54
16772867 2006
44
Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171. 54 61
16580884 2006
45
Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. 54 61
16650133 2006
46
The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. 54 61
16504945 2006
47
Influence of lamotrigine and topiramate on MDR1 expression in difficult-to-treat temporal lobe epilepsy. 61 54
16499746 2006
48
Lack of association between a GABA receptor 1 gene polymorphism and temporal lobe epilepsy. 54 61
16499773 2006
49
Implications of the aquaporin-4 structure on array formation and cell adhesion. 54 61
16325200 2006
50
Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients. 61 54
16311265 2006

Variations for Temporal Lobe Epilepsy

Expression for Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for Temporal Lobe Epilepsy

Pathways related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.76 SLC1A2 SCN1B NPY GRIN2A GFAP GABBR2
2 11.69 NPY GRIN2A GABBR2 GABBR1 BDNF
3 11.68 TSPO GRIN2A CALB1
4 11.62 PDYN GFAP BDNF
5
Show member pathways
11.57 PDYN GRIN2A BDNF
6 10.49 GABBR2 GABBR1
7 10.36 GABBR2 GABBR1

GO Terms for Temporal Lobe Epilepsy

Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.77 RELN PDYN GABBR1 CALB1 BDNF
2 glutamatergic synapse GO:0098978 9.76 SLC1A2 LGI1 GRIN2A CALB1
3 neuron projection GO:0043005 9.65 SV2B RELN GRIN2A GABBR2 CALB1
4 cell body GO:0044297 9.58 SLC1A2 GFAP CALB1
5 axon GO:0030424 9.55 SLC1A2 SCN1B PVALB CALB1 BDNF
6 astrocyte projection GO:0097449 9.43 SLC1A2 GFAP
7 cuticular plate GO:0032437 9.32 PVALB CALB1
8 synapse GO:0045202 9.23 SV2B PDYN NPY LGI1 GRIN2A GABBR2
9 G protein-coupled receptor heterodimeric complex GO:0038039 8.96 GABBR2 GABBR1

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron projection development GO:0010976 9.65 SCN1B RELN BDNF
2 axon guidance GO:0007411 9.62 SCN1B RELN LGI1 BDNF
3 modulation of chemical synaptic transmission GO:0050804 9.58 RELN GRIN2A BDNF
4 response to wounding GO:0009611 9.54 SLC1A2 GRIN2A GFAP
5 positive regulation of glial cell proliferation GO:0060252 9.46 TSPO GFAP
6 response to pain GO:0048265 9.43 TSPO RELN
7 locomotion GO:0040011 9.26 SCN1B GRIN2A
8 D-aspartate import across plasma membrane GO:0070779 9.16 SLC1A2 GFAP
9 long-term synaptic potentiation GO:0060291 9.13 RELN GRIN2A GFAP
10 chemical synaptic transmission GO:0007268 9.1 SV2B SLC1A2 PDYN NPY GRIN2A GABBR2

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled GABA receptor activity GO:0004965 8.62 GABBR2 GABBR1

Sources for Temporal Lobe Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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