Temporal Lobe Epilepsy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Temporal Lobe Epilepsy

MalaCards integrated aliases for Temporal Lobe Epilepsy:

Name: Temporal Lobe Epilepsy ¹¹ ¹⁴ ³⁶ ¹⁶ ⁷⁵

Epilepsy, Temporal Lobe ¹¹ ⁴³ ⁷¹

Epilepsy Temporal Lobe ⁵³

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Neuronal diseases Oral diseases Eye diseases Ear diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:3328

MeSH ⁴³ D004833

NCIt ⁴⁹ C177244

SNOMED-CT ⁶⁸ 84340007

EFO ¹⁶ EFO_0000773

UMLS ⁷¹ C0014556

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Summaries for Temporal Lobe Epilepsy

MalaCards based summary: Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to epilepsy, familial temporal lobe, 7 and epilepsy, familial temporal lobe, 1, and has symptoms including seizures An important gene associated with Temporal Lobe Epilepsy is ADARB2-AS1 (ADARB2 Antisense RNA 1), and among its related pathways/superpathways are Neuroinflammation and glutamatergic signaling and Neuroscience. The drugs Citalopram and Dexetimide have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and amygdala, and related phenotypes are nervous system and normal

Wikipedia: ⁷⁵ Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system which is characterized by... more...

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Related Diseases for Temporal Lobe Epilepsy

Diseases in the Temporal Lobe Epilepsy family:

Epilepsy, Familial Temporal Lobe, 1	Epilepsy, Familial Temporal Lobe, 2
Epilepsy, Familial Temporal Lobe, 3	Epilepsy, Familial Temporal Lobe, 4
Epilepsy, Familial Temporal Lobe, 5	Epilepsy, Familial Temporal Lobe, 6
Epilepsy, Familial Temporal Lobe, 7	Epilepsy, Familial Temporal Lobe, 8

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 502)

#	Related Disease	Score	Top Affiliating Genes
1	epilepsy, familial temporal lobe, 7	33.4	RELN LGI1
2	epilepsy, familial temporal lobe, 1	33.3	SCN1B RELN LGI1
3	autosomal dominant epilepsy with auditory features	32.8	RELN LGI1
4	status epilepticus	31.9	TSPO SLC1A2 PVALB NPY LGI1 GFAP
5	epilepsy	31.9	TSPO SV2B SLC1A2 SCN1B RELN PVALB
6	focal epilepsy	31.9	TSPO SLC1A2 PVALB PDYN NPY LGI1
7	amnestic disorder	31.6	TSPO PDYN LGI1 BDNF
8	mood disorder	31.5	RELN PDYN NPY GABBR1 BDNF
9	anxiety	31.5	TSPO PDYN NPY GABBR1 BDNF
10	ganglioglioma	31.4	SLC1A2 PVALB GFAP
11	major depressive disorder	31.4	TSPO PVALB PDYN NPY BDNF
12	psychotic disorder	31.3	SLC1A2 RELN PVALB PDYN NPY CALB1
13	epilepsy, idiopathic generalized	31.2	TSPO SCN1B PVALB LGI1 GABBR1
14	obsessive-compulsive disorder	31.1	PDYN NPY GABBR1 BDNF
15	dystonia	31.1	PVALB PDYN NPY GABBR1 BDNF
16	epilepsy, myoclonic juvenile	31.1	SCN1B PVALB LGI1 GABBR1
17	toxic encephalopathy	31.0	SLC1A2 GFAP BDNF
18	migraine with or without aura 1	30.9	SLC1A2 PDYN NPY GFAP BDNF
19	choreatic disease	30.9	PVALB LGI1 BDNF
20	post-traumatic stress disorder	30.9	PVALB NPY BDNF
21	attention deficit-hyperactivity disorder	30.8	RELN PVALB PDYN NPY BDNF
22	encephalomalacia	30.8	SLC1A2 GFAP BDNF
23	adjustment disorder	30.8	TSPO BDNF
24	neonatal hypoxic and ischemic brain injury	30.8	PVALB BDNF
25	childhood absence epilepsy	30.7	TSPO SLC1A2 SCN1B PVALB PDYN LGI1
26	anterograde amnesia	30.7	TSPO LGI1 BDNF
27	retrograde amnesia	30.7	LGI1 BDNF
28	generalized epilepsy with febrile seizures plus	30.7	SCN1B PVALB LGI1
29	substance abuse	30.7	PDYN NPY BDNF
30	west syndrome	30.6	SCN1B PVALB NPY LGI1
31	alzheimer disease, familial, 1	30.6	TSPO SLC1A2 RELN PVALB PDYN NPY
32	amyotrophic lateral sclerosis 1	30.5	TSPO SLC1A2 PVALB GFAP CALB1 BDNF
33	bipolar disorder	30.5	TSPO SLC1A2 RELN PVALB PDYN GFAP
34	withdrawal disorder	30.5	TSPO PDYN BDNF
35	alcohol use disorder	30.4	PDYN NPY BDNF
36	alexithymia	30.4	PDYN BDNF
37	tobacco addiction	30.4	PDYN GABBR2 BDNF
38	spinal cord injury	30.4	GFAP BDNF
39	speech and communication disorders	30.3	LGI1 GFAP BDNF
40	schizophrenia	30.3	TSPO SLC1A2 RELN PVALB PDYN NPY
41	motor neuron disease	30.2	SLC1A2 PVALB CALB1 BDNF
42	stroke, ischemic	30.2	TSPO SLC1A2 GFAP BDNF
43	nervous system disease	30.1	TSPO SLC1A2 PVALB PDYN NPY LGI1
44	huntington disease	30.1	TSPO SLC1A2 PDYN NPY2R NPY CALB1
45	epilepsy, familial temporal lobe, 2	11.9
46	epilepsy, familial temporal lobe, 5	11.8
47	mesial temporal lobe epilepsy with hippocampal sclerosis	11.8
48	epilepsy, familial temporal lobe, 3	11.7
49	epilepsy, familial temporal lobe, 8	11.7
50	epilepsy, familial temporal lobe, 6	11.7

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:

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Symptoms & Phenotypes for Temporal Lobe Epilepsy

UMLS symptoms related to Temporal Lobe Epilepsy:

seizures

MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.22	ACOT7 BDNF CALB1 CASP2 GABBR1 GABBR2
2	normal	MP:0002873	10.02	BDNF CALB1 GFAP NPY PVALB SCN1B
3	growth/size/body region	MP:0005378	10	ACOT7 BDNF GABBR1 GABBR2 GFAP LGI1
4	behavior/neurological	MP:0005386	9.86	ACOT7 BDNF CALB1 GABBR1 GABBR2 GFAP
5	adipose tissue	MP:0005375	9.8	ACOT7 GABBR1 LGI1 NPY NPY2R PDYN
6	mortality/aging	MP:0010768	9.44	BDNF CASP2 GABBR1 GABBR2 GFAP LGI1

Sources

Drugs & Therapeutics for Temporal Lobe Epilepsy

Drugs for Temporal Lobe Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Citalopram

Approved

Phase 4

59729-32-7, 59729-33-8

2771

2

Dexetimide

Withdrawn

Phase 4

21888-98-2

30843

3

Psychotropic Drugs

Phase 4

4

Antidepressive Agents

Phase 4

5

Serotonin Uptake Inhibitors

Phase 4

6

Naluzotan

Investigational

Phase 2

740873-06-7

7

Neurotransmitter Agents

Phase 2

8

Serotonin Receptor Agonists

Phase 2

9

Serotonin 5-HT1 Receptor Agonists

Phase 2

10

Serotonin

Investigational, Nutraceutical

Phase 2

50-67-9

5202

11

Sertraline

Approved

79617-96-2

68617

12

Glutamic acid

Approved, Nutraceutical

56-86-0

33032

Synonyms:

(+)-Estrone

(1S)-2-[(3-O-b-D-Glucopyranosyl-b-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoate

(1S)-2-[(3-O-b-D-Glucopyranosyl-b-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoic acid

(1S)-2-[(3-O-beta-D-Glucopyranosyl-beta-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoic acid

(1S)-2-[(3-O-Β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoate

(1S)-2-[(3-O-Β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoic acid

(2R)-2,3-Dihydroxypropanoic acid

(2S)-2-Aminopentanedioate

(2S)-2-Aminopentanedioic acid

(3R,4S,5R)-5-[(1R)-1-Carboxy-2,2-difluoro-1-(phosphonooxy)ethoxy]-4-hydroxy-3-(phosphonooxy)cyclohex-1-ene-1-carboxylate

(R)-2,3-Dihydroxypropanoic acid

(R)-Glycerate

(R)-Glyceric acid

(S)-(+)-Glutamate

(S)-(+)-Glutamic acid

(S)-2-Aminopentanedioate

(S)-2-Aminopentanedioic acid

(S)-Glutamate

(S)-Glutamic acid

1,3,5(10)-Estratrien-3-ol-17-one

1-Amino-2-hydroxyethane

1-Aminopropane-1,3-dicarboxylate

1-Amino-propane-1,3-dicarboxylate

1-Aminopropane-1,3-dicarboxylic acid

1-Amino-propane-1,3-dicarboxylic acid

2 Acetamido 2 deoxy D glucose

2 Acetamido 2 deoxyglucose

2 Aminoethanol

2-Acetamido-2-deoxy-D-glucose

2-Acetamido-2-deoxyglucose

2-Amino-1-ethanol

2-Aminoethan-1-ol

2-Aminoethanol

2-Amino-ethanol

2-Aminoethyl alcohol

2-Aminoglutarate

2-Aminoglutaric acid

2-Aminopentanedioate

2-Aminopentanedioic acid

2-Ethanolamine

2-Hydroxyethanamine

2-Hydroxyethylamine

3a,7a,12a-Trihydroxy-5b-cholan-24-oylglycine

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oylglycine

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid-24-glycine

3alpha,7alpha,12alpha-Trihydroxy-N-(carboxymethyl)-5beta-cholan-24-amide

3-Hydroxy-1,3,5(10)-estratrien-17-one

3-Hydroxy-17-keto-estra-1,3,5-triene

3-Hydroxyestra-1,3,5(10)-trien-17-one

3-Hydroxyestra-1,3,5(10)-triene-17-one

3-Hydroxyoestra-1,3,5(10)-trien-17-one

3Α,7α,12α-trihydroxy-5β-cholan-24-oylglycine

3Α,7α,12α-trihydroxy-5β-cholanic acid-24-glycine

3Α,7α,12α-trihydroxy-N-(carboxymethyl)-5β-cholan-24-amide

a,b-Hydroxypropionate

a,b-Hydroxypropionic acid

a-Aminoglutarate

a-Aminoglutaric acid

Acetylglucosamine

Acide glutamique

Acido glutamico

ácido glutámico

Acidum glutamicum

Aciglut

Aethanolamin

a-Glutamate

a-Glutamic acid

alpha,beta-Hydroxypropionate

alpha,beta-Hydroxypropionic acid

alpha-Aminoglutarate

alpha-Aminoglutaric acid

alpha-Glutamate

alpha-Glutamic acid

Aluminum L glutamate

Aluminum L-glutamate

Aminoethanol

Aminoglutarate

Aminoglutaric acid

b-Aminoethanol

b-Aminoethyl alcohol

beta-Aminoethanol

beta-Aminoethyl alcohol

beta-Ethanolamine

beta-Hydroxyethylamine

b-Ethanolamine

b-Hydroxyethylamine

Cholylglycine

Colamine

D Glutamate

D1,3,5(10)-Estratrien-3-ol-17-one

D-2,3-Dihydroxypropanoic acid

D-GlcNAc

D-Glutamate

D-Glycerate

D-Glyceric acid

D-GroA

E

E 620

E620

E-620

Envision conditioner PDD 9020

Estrone, (+-)-isomer

Estrone, (8 alpha)-isomer

Estrone, (9 beta)-isomer

Estrovarin

ETA

Ethylolamine

FEMA NO. 3285

Follicular hormone

Folliculin

Glt

Glu

Glusate

Glut

Glutacid

Glutamate

Glutamate, potassium

GLUTAMIC ACID

Glutamic acid, (D)-isomer

Glutamicol

Glutamidex

Glutaminate

Glutaminic acid

Glutaminol

Glutaton

Glycerate

Glycine cholate

Glycinol

Glycocholate

Glycocholate sodium

Glycocholic acid, sodium salt

Glycoreductodehydrocholic acid

Glycylcholate

Glycylcholic acid

Hauck brand OF estrone

Hea

H-Glycinol

Hyrex brand OF estrone

INS NO.620

INS-620

Kestrone

L Glutamate

L Glutamic acid

L-(+)-Glutamate

L-(+)-Glutamic acid

L-a-Aminoglutarate

L-a-Aminoglutaric acid

L-alpha-Aminoglutarate

L-alpha-Aminoglutaric acid

L-Glu

L-Glu|L-glutamate|poly-L-glutamate

L-GLUTAMATE

L-Glutamate, aluminum

L-GLUTAMIC ACID

L-Glutaminate

L-Glutaminic acid

L-Glutaminsaeure

MEA

Monoaethanolamin

MONOETHANOLAMINE

N Acetyl D glucosamine

N-(Carboxymethyl)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-amide

N-(Carboxymethyl)-3α,7α,12α-trihydroxy-5β-cholan-24-amide

N-[(3a,5b,7a,12a)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycine

N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycine

N-[(3Α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]glycine

N-Acetylchitosamine

N-Acetyl-D-glucosamine

N-Choloylglycine

N-Choloyl-glycine

NSC-143503

Oestrone

Olamine

Potassium glutamate

R-Glycerate

R-Glyceric acid

Unigen

Vortech brand OF estrone

Wehgen

Α,β-hydroxypropionate

Α,β-hydroxypropionic acid

Β-aminoethanol

Β-aminoethyl alcohol

Β-ethanolamine

Β-hydroxyethylamine

13

Fluorodeoxyglucose F18

14

Anesthetics

15

Fluorides

16

Anticonvulsants

Interventional clinical trials:

(show top 50) (show all 54)

#	Name	Status	NCT ID	Phase	Drugs
1	Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy. A Double-blind, Placebo-controlled Study.	Completed	NCT00595699	Phase 4	escitalopram;placebo
2	Hippocampal and Thalamic Deep Brain Stimulation for Bilateral Temporal Lobe Epilepsy	Recruiting	NCT04164056	Phase 4
3	Early Randomized Surgical Epilepsy Trial	Completed	NCT00040326	Phase 3	antiepileptic drugs
4	Medical vs Electrical Therapy for Temporal Lobe Epilepsy	Terminated	NCT00717431	Phase 3
5	A First-In-Human (FIH) Study of Inhibitory Interneurons (NRTX- 1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)	Recruiting	NCT05135091	Phase 1, Phase 2
6	A Phase II Clinical Trial of PRX-00023 Therapy in Localization-Related Epilepsy	Terminated	NCT01281956	Phase 2	PRX-00023;Placebo
7	Phase 1 Study of Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy	Completed	NCT00916266	Phase 1
8	Regenerating the Adult Human Brain Through Exercise	Recruiting	NCT05179083	Phase 1
9	Efficacy of Transcranial Direct Current Stimulation for Treating Working Memory Dysfunction and Depression For Patients With Temporal Lobe Epilepsy	Withdrawn	NCT02268578	Phase 1
10	Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery	Unknown status	NCT02590419
11	Role of Advanced Magnetic Resonance Imaging in Diagnosis of Idiopathic Temporal Lobe Epilepsy	Unknown status	NCT03643471
12	Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE)	Unknown status	NCT02383407
13	COMET Study Effectiveness of a Cognitive Remediation Program of Memory in Patients With Temporal Lobe Epilepsy	Unknown status	NCT02589470
14	Prospective Randomized Controlled Study of Vagus Nerve Stimulation Therapy in the Patients With Medically Refractory Medial Temporal Lobe Epilepsy; Controlled Randomized Vagus Nerve Stimulation Versus Resection (CoRaVNStiR)	Unknown status	NCT02089243
15	Prospective Randomized Controlled Study of Neurostimulation in the Medial Temporal Lobe for Patients With Medically Refractory Medial Temporal Lobe Epilepsy; Controlled Randomized Stimulation Versus Resection (CoRaStiR)	Unknown status	NCT00431457
16	Study on the Safety and Effects of Transcranial Direct Current Stimulation (tDCS) in the Treatment of Depressive Symptoms in Participants With Temporal Lobe Epilepsy: A Randomized, Double-blind, Sham-controlled Clinical Trial	Unknown status	NCT03871842
17	Stereotactic-EEG Guided Radio-frequency Thermocoagulation Versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy With Hippocampus Sclerosis	Unknown status	NCT03941613
18	Evaluation of Stress Sensitivity and Hyperemotivity in Temporal Lobe Epilepsy With Enlarged Amygdala Compared to Epilepsy Without Enlarged Amygdala (Temporal and Extra-temporal) and a Group of Healthy Volunteers: Pilot Study.	Unknown status	NCT03464370
19	Anticonvulsive Effects of Transcranial DC Stimulation in Pharmacoresistant Focal Epilepsy	Completed	NCT00344877
20	Closed Loop Auditory Stimulus in Sleep and epilepsY	Completed	NCT05159609
21	Subcutaneous EEG in Epilepsy - Proof of Concept and Clinical Applications	Completed	NCT02946151
22	Symmetricity-Driven Learning Framework for Pediatric Temporal Lobe Epilepsy Detection Using 18F-FDG-PET Imaging	Completed	NCT04169581
23	Radiosurgery Versus Lobectomy for Temporal Lobe Epilepsy	Completed	NCT00860145
24	Treatment Of Depression In Patients With Temporal Lobe Epilepsy: Comparative Study Of Cognitive Behavioral Therapy Vs. Selective Serotonin Reuptake Inhibitors	Completed	NCT02262156		SSRI
25	Functional MRI (fMRI) and Diffusion Tensor Imaging (DTI) in Temporal Lobe Epilepsy	Completed	NCT00081432
26	GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression	Completed	NCT00931619
27	Assessment of [11C]DPA-713 in Temporal Lobe Epilepsy	Completed	NCT01793532
28	Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy: New Targets for Diagnosis and Prediction of Drug Resistance	Completed	NCT01563627
29	Noninvasive Language Mapping in Patients With Localization-Related Epilepsy	Completed	NCT00706160
30	Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy	Completed	NCT00001672
31	Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation	Completed	NCT02339376
32	Brain Network Activation Analysis in Epilepsy	Completed	NCT03265925
33	Spectroscopic Determination of Brain Tumor Cells	Completed	NCT00067418
34	Electrophysiological Biomarkers During Invasive Monitoring of Mesial Temporal Lobe Epilepsy Patients.	Recruiting	NCT04710004
35	Stereotactic Laser Ablation for Temporal Lobe Epilepsy	Recruiting	NCT02844465
36	Functional Anterior Temporal Lobectomy Via Minicraniotomy as a Novel Surgical Therapy for Temporal Lobe Epilepsy: a Randomized, Controlled Trial	Recruiting	NCT05019404
37	Evaluation of the 24/7 EEG SubQ System for Ultra Long-Term Recording of Patients With Temporal Lobe Epilepsy An Open-label, Prospective, Paired, Comparative Study	Recruiting	NCT04526418
38	Cognitive and Emotional Function and Brain Reorganisation Associated to Auditory Abilities : Impact of Tinnitus	Recruiting	NCT04717388
39	Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics	Recruiting	NCT04649008	Early Phase 1
40	Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients	Recruiting	NCT05339438
41	Self-modulation of the Sense of Agency by Means of Real-time Neurofeedback	Recruiting	NCT05214833
42	Surgery as a Treatment for Medically Intractable Epilepsy	Recruiting	NCT01273129
43	Investigating Epilepsy: Screening and Evaluation	Recruiting	NCT03478852
44	EASINESS-TRIAL - An Analysis of Standardized Outcome References From an International Multicentre Cohort	Recruiting	NCT04952298
45	Gene Expression Changes of Brain Tissue in Human Temporal Lobe Epilepsy With Hippocampal Sclerosis	Active, not recruiting	NCT04917939
46	Thalamic Stimulation to Prevent Impaired Consciousness in Epilepsy	Active, not recruiting	NCT04897776
47	LIFUP for Treatment of Temporal Lobe Epilepsy	Enrolling by invitation	NCT02151175
48	Epilepsy Surgery and Cognition, Psychiatric Function and Quality of Life - Outcome 10 Years or More After Surgery	Enrolling by invitation	NCT04264780
49	Network Neuro-modulation for Mesial Temporal Lobe Epilepsy	Not yet recruiting	NCT05608408
50	Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy	Not yet recruiting	NCT05609084

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Mephenytoin

Phenytoin

Phenytoin sodium

PHENYTOIN SODIUM,EXTENDED

PHENYTOIN SODIUM,PROMPT

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:

Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy

Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:

Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: epilepsy, temporal lobe

Sources

Genetic Tests for Temporal Lobe Epilepsy

Sources

Anatomical Context for Temporal Lobe Epilepsy

Organs/tissues related to Temporal Lobe Epilepsy:

MalaCards : Temporal Lobe, Brain, Amygdala, Bone Marrow, Cortex, Bone, Thalamus

Sources

Publications for Temporal Lobe Epilepsy

Articles related to Temporal Lobe Epilepsy:

(show top 50) (show all 12045)

#	Title	Authors	PMID	Year
1	Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families. ⁵³ ⁶²	Kawamata J...Takahashi R	19780791	2010
2	Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. ⁵³ ⁶²	Malter MP...Bien CG	20437582	2010
3	Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. ⁵³ ⁶²	Herranz-Perez V...Perez-Tur J	19833108	2010
4	Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. ⁵³ ⁶²	Heuser K...Ottersen OP	19864112	2010
5	Aberrant glutamate receptor 5 expression in temporal lobe epilepsy lesions. ⁵³ ⁶²	Li JM...Zhou D	19941835	2010
6	Conditional downregulation of brain- derived neurotrophic factor and tyrosine kinase receptor B blocks epileptogenesis in the human temporal lobe epilepsy hippocampus. ⁵³ ⁶²	Hou X...Zhang L	20228460	2010
7	The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study. ⁵³ ⁶²	Wang Y...Eid T	19747915	2009
8	[Expression and function of Cx32 and Cx43 junctions in medically intractable temporal lobe epilepsy in human]. ⁵³ ⁶²	Yao LF...Zhang LM	20137634	2009
9	Using cerebral white matter for estimation of nondisplaceable binding of 5-HT1A receptors in temporal lobe epilepsy. ⁵³ ⁶²	Giovacchini G...Theodore WH	19837769	2009
10	Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy. ⁵³ ⁶²	Pirker S...Sperk G	19437412	2009
11	Positive correlation between the density of neuropeptide y positive neurons in the amygdala and parameters of self-reported anxiety and depression in mesiotemporal lobe epilepsy patients. ⁵³ ⁶²	Frisch C...Helmstaedter C	19482265	2009
12	Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy. ⁵³ ⁶²	Kobow K...Blumcke I	19287316	2009
13	Haploinsufficiency of glutamine synthetase increases susceptibility to experimental febrile seizures. ⁵³ ⁶²	van Gassen KL...de Graan PN	19170755	2009
14	Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP. ⁵³ ⁶²	Sorensen AT...Kokaia M	19038255	2009
15	Candidate genes for temporal lobe epilepsy: a replication study. ⁵³ ⁶²	Salzmann A...Malafosse A	19066720	2008
16	[Aquaporin-4]. ⁵³ ⁶²	Tani K...Fujiyoshi Y	19198125	2008
17	Association between the gamma-aminobutyric acid type B receptor 1 and 2 gene polymorphisms and mesial temporal lobe epilepsy in a Han Chinese population. ⁵³ ⁶²	Wang X...Liu Y	18653317	2008
18	GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: new evidence. ⁵³ ⁶²	Kauffman MA...Kochen S	18255321	2008
19	M129V polymorphism in the prion protein gene is not associated with mesial temporal lobe epilepsy in a Han Chinese population. ⁵³ ⁶²	Wang X...Liu Y	18549399	2008
20	Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. ⁵³ ⁶²	Noe F...Vezzani A	18477594	2008
21	Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. ⁵³ ⁶²	Fricchione G...Stefano GB	18509280	2008
22	Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain. ⁵³ ⁶²	Bankstahl JP...Loscher W	18394657	2008
23	Analysis of LGI1 promoter sequence, PDYN and GABBR1 polymorphisms in sporadic and familial lateral temporal lobe epilepsy. ⁵³ ⁶²	Bovo G...Nobile C	18355961	2008
24	Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. ⁵³ ⁶²	Lee SG...Fisher PB	18326497	2008
25	Genetic etiology of new forms of familial epilepsy. ⁵³ ⁶²	Wang X...Lu Y	17981785	2008
26	Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy? ⁵³ ⁶²	Eid T...de Lanerolle NC	18226171	2008
27	Transcriptionally less active prodynorphin promoter alleles are associated with temporal lobe epilepsy: a case-control study and meta-analysis. ⁵³ ⁶²	Kauffman MA...Kochen S	18334734	2008
28	The NR1 N-methyl-D-aspartate subunit and brain-derived neurotrophic factor in temporal lobe epilepsy hippocampus: a comparison of patients with and without coexisting psychiatric symptoms. ⁵³ ⁶²	Toro CT...Deakin JF	17919302	2007
29	5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression. ⁵³ ⁶²	Hasler G...Theodore WH	17588547	2007
30	Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. ⁵³ ⁶²	Langer O...Baumgartner C	17484754	2007
31	Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. ⁵³ ⁶²	Pitsch J...Becker AJ	17446080	2007
32	Seizure suppression by GDNF gene therapy in animal models of epilepsy. ⁵³ ⁶²	Kanter-Schlifke I...Kokaia M	17387333	2007
33	Limbic encephalitis with autoantibodies against the glutamate receptor epsilon 2 mimicking temporal lobe epilepsy. ⁵³ ⁶²	Yoshino A...Takahashi Y	17472608	2007
34	Association between the M129V variant allele of PRNP gene and mild temporal lobe epilepsy in women. ⁵³ ⁶²	Labate A...Quattrone A	17092648	2007
35	Hippocampal Nogo-A and neo-Timm's staining in amygdala kindling rats. ⁵³ ⁶²	Takeda Y...Kobayashi H	17439704	2007
36	Neuropeptide Y in the dentate gyrus. ⁵³ ⁶²	Sperk G...Colmers WF	17765725	2007
37	Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. ⁵³ ⁶²	Scheffer IE...Berkovic SF	17020904	2007
38	Potentiation of anti-epileptic drugs effectiveness by pyronaridine in refractory epilepsy. ⁵³ ⁶²	Asadi-Pooya AA...Sperling MR	17368747	2007
39	Viral risk factor for seizures: pathobiology of dynorphin in herpes simplex viral (HSV-1) seizures in an animal model. ⁵³ ⁶²	Solbrig MV...Perng GC	16843674	2006
40	Syntaxin 1A promotes the endocytic sorting of EAAC1 leading to inhibition of glutamate transport. ⁵³ ⁶²	Yu YX...Pei G	16959903	2006
41	Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy. ⁵³ ⁶²	Malthankar-Phatak GH...Lai JC	16922873	2006
42	Architectural (Type IA) focal cortical dysplasia and parvalbumin immunostaining in temporal lobe epilepsy. ⁵³ ⁶²	Garbelli R...Spreafico R	16822257	2006
43	Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease. ⁵³ ⁶²	Gil V...del Rio JA	16772867	2006
44	Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171. ⁵³ ⁶²	Coimbra ER...Walz R	16580884	2006
45	Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. ⁵³ ⁶²	van Vliet EA...Gorter JA	16650133	2006
46	The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. ⁵³ ⁶²	Schulte U...Fakler B	16504945	2006
47	Influence of lamotrigine and topiramate on MDR1 expression in difficult-to-treat temporal lobe epilepsy. ⁵³ ⁶²	Wang-Tilz Y...Stefan H	16499746	2006
48	Lack of association between a GABA receptor 1 gene polymorphism and temporal lobe epilepsy. ⁵³ ⁶²	Stogmann E...Zimprich F	16499773	2006
49	Implications of the aquaporin-4 structure on array formation and cell adhesion. ⁵³ ⁶²	Hiroaki Y...Fujiyoshi Y	16325200	2006
50	Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients. ⁵³ ⁶²	Notenboom RG...de Graan PN	16311265	2006

Sources

Genes for Temporal Lobe Epilepsy

Genes related to Temporal Lobe Epilepsy (0 elite genes):

(show all 46)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ADARB2-AS1	ADARB2 Antisense RNA 1	RNA Gene	153.86	Experimental evidence: Expression ³⁷ DISEASES inferred ¹⁴	25552301
2	UCA1	Urothelial Cancer Associated 1	RNA Gene	153.83	Experimental evidence: Expression ³⁷ DISEASES inferred ¹⁴	25552301
3	MAP3K14-AS1	MAP3K14 Antisense RNA 1	RNA Gene	150	Experimental evidence: Expression ³⁷	25552301
4	RELN	Reelin	Protein Coding	28.16	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	19287316
5	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	26.55	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12023020 19833108 15660777 (more) 16504945 15079010 12205652 15079011 17981785 15199738 16014869 18355961 15021241 19780791
6	PVALB	Parvalbumin	Protein Coding	23.34	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1865007 9329455 16822257
7	PDYN	Prodynorphin	Protein Coding	23.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11506405 18355961 18334734 (more) 11835385 9332884 19437412 19066720 16843674 10098940
8	SV2B	Synaptic Vesicle Glycoprotein 2B	Protein Coding	23	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)
9	TSPO	Translocator Protein	Protein Coding	21.85	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11893007 12199729 11518000 (more) 10599778 10668692 10390953 7788107 9365376 10971598 8931589 9585356 9305338 11294927 11835376
10	SLC1A2	Solute Carrier Family 1 Member 2	Protein Coding	21.83	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10336123 18326497
11	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	21.78	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10611117
12	NPY	Neuropeptide Y	Protein Coding	21.64	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11466452 15337376 1361332 (more) 10082852 17765725 11287369 19482265 9305828 15716408 19038255 18477594 9302518
13	ACOT7	Acyl-CoA Thioesterase 7	Protein Coding	21.62	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)
14	GABBR1	Gamma-Aminobutyric Acid Type B Receptor Subunit 1	Protein Coding	21.48	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18255321 15799783 16278087 (more) 18653317 16499773
15	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	21.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16061515 20228460 10082852 (more) 12969262 10377368 11506401 16105728 16145610
16	NPY2R	Neuropeptide Y Receptor Y2	Protein Coding	21.22	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)
17	CALB1	Calbindin 1	Protein Coding	20.99	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9015323 10805100
18	SCN1B	Sodium Voltage-Gated Channel Beta Subunit 1	Protein Coding	20.48	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17020904
19	CASP2	Caspase 2	Protein Coding	20.19	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)
20	GABBR2	Gamma-Aminobutyric Acid Type B Receptor Subunit 2	Protein Coding	20.18	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	14625043 18653317
21	SLC1A3	Solute Carrier Family 1 Member 3	Protein Coding	20.01	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10336123
22	GRIK1	Glutamate Ionotropic Receptor Kainate Type Subunit 1	Protein Coding	19.8	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19941835 9848088
23	GAD1	Glutamate Decarboxylase 1	Protein Coding	19.66	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	20437582 10441235 12585688
24	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	19.29	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12629228 15111672 15193619 (more) 14985263 16000281 19837769 17588547
25	AQP4	Aquaporin 4	Protein Coding	19.26	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15517312 19198125 16325200 (more) 19864112
26	SLC1A1	Solute Carrier Family 1 Member 1	Protein Coding	19.01	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16959903
27	GLUL	Glutamate-Ammonia Ligase	Protein Coding	18.85	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16095760 14723991 19170755 (more) 18226171 19747915
28	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	18.58	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17472608
29	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	18.54	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17919302
30	GAD2	Glutamate Decarboxylase 2	Protein Coding	18.4	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10441235
31	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	18.39	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	20228460
32	GRM1	Glutamate Metabotropic Receptor 1	Protein Coding	17.64	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17446080 10744030
33	RTN4	Reticulon 4	Protein Coding	17.56	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15619232 15245492 16772867 (more) 17439704
34	GRIK2	Glutamate Ionotropic Receptor Kainate Type Subunit 2	Protein Coding	17.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11442354 9848088
35	GRM5	Glutamate Metabotropic Receptor 5	Protein Coding	17.08	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16311265
36	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	16.5	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	14706787 17484754 16650133 (more) 17368747 15452305 18394657 15101825 12399076 15066676 15716304 16499746
37	NTF3	Neurotrophin 3	Protein Coding	15.68	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12969262
38	GJA1	Gap Junction Protein Alpha 1	Protein Coding	15.49	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	20137634 11852037 11180508
39	PRNP	Prion Protein	Protein Coding	15.31	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17092648 15304595 18549399 (more) 16580884
40	IL1B	Interleukin 1 Beta	Protein Coding	15.26	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
41	KCNJ10	Potassium Inwardly Rectifying Channel Subfamily J Member 10	Protein Coding	14.96	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
42	ADORA1	Adenosine A1 Receptor	Protein Coding	14.96	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8295723 8963679
43	OPRM1	Opioid Receptor Mu 1	Protein Coding	14.44	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1656846 10514872 18509280 (more) 9066357
44	SCG2	Secretogranin II	Protein Coding	14.43	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11506405 10999531
45	APOE	Apolipoprotein E	Protein Coding	14.34	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
46	CHGB	Chromogranin B	Protein Coding	14.17	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11506405

Sources

Variations for Temporal Lobe Epilepsy

Sources

Expression for Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Sources

Pathways for Temporal Lobe Epilepsy

Pathways related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroinflammation and glutamatergic signaling ⁷⁴	11.76	SLC1A2 GFAP BDNF
2	Neuroscience ³	11.7	SLC1A2 SCN1B NPY GFAP GABBR2 GABBR1
3	Sensory perception of taste ⁶⁶ Show member pathways Class C/3 (Metabotropic glutamate/pheromone receptors) ⁶⁶ Sensory perception of salty taste ⁶⁶ Sensory perception of sour taste ⁶⁶ Sensory perception of sweet, bitter, and umami (glutamate) taste ⁶⁶	11.67	SCN1B GABBR2 GABBR1
4	Spinal cord injury ⁷⁴	11.49	PDYN GFAP BDNF
5	Sympathetic Nerve Pathway (Neuroeffector Junction) ⁶⁰	10.77	NPY2R NPY
6	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics ⁶⁰	10.62	NPY2R NPY
7	Synaptic Neurotransmission: GABAergic Inhibition ⁶⁵	10.39	GABBR2 GABBR1
8	GABA receptor signaling ⁷⁴	10.07	GABBR2 GABBR1

Sources

GO Terms for Temporal Lobe Epilepsy

Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:0030424	10.01	SLC1A2 SCN1B PVALB CALB1 BDNF
2	cuticular plate	GO:0032437	9.67	PVALB CALB1
3	synapse	GO:0045202	9.65	SV2B SLC1A2 PVALB PDYN LGI1 GABBR2
4	G protein-coupled receptor heterodimeric complex	GO:0038039	9.56	GABBR2 GABBR1
5	GABA receptor complex	GO:1902710	9.5	GABBR2 GABBR1
6	G protein-coupled GABA receptor complex	GO:1902712	9.46	GABBR1 GABBR2
7	neuron projection	GO:0043005	9.4	SV2B RELN NPY2R NPY GABBR2 GABBR1

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	axon guidance	GO:0007411	10.01	SCN1B RELN LGI1 BDNF
2	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	GO:0007193	9.85	NPY2R GABBR2 GABBR1
3	neuron projection development	GO:0031175	9.8	SCN1B NPY LGI1 GFAP
4	chemical synaptic transmission	GO:0007268	9.65	SV2B SLC1A2 PDYN NPY GABBR2
5	D-aspartate import across plasma membrane	GO:0070779	9.56	GFAP SLC1A2
6	neuron-glial cell signaling	GO:0150099	9.46	GABBR1 GABBR2
7	regulation of presynaptic cytosolic calcium ion concentration	GO:0099509	8.92	SV2B NPY CALB1

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled GABA receptor activity	GO:0004965	8.92	GABBR2 GABBR1

Sources

Sources for Temporal Lobe Epilepsy

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: TMP001 MIFTS: 49	Temporal Lobe Epilepsy Categories: Ear diseases, Eye diseases, Genetic diseases, Neuronal diseases, Oral diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Temporal Lobe Epilepsy

Aliases & Classifications for Temporal Lobe Epilepsy

MalaCards integrated aliases for Temporal Lobe Epilepsy:

Classifications:

External Ids:

Summaries for Temporal Lobe Epilepsy

Related Diseases for Temporal Lobe Epilepsy

Diseases in the Temporal Lobe Epilepsy family:

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:

Symptoms & Phenotypes for Temporal Lobe Epilepsy

UMLS symptoms related to Temporal Lobe Epilepsy:

MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

Drugs & Therapeutics for Temporal Lobe Epilepsy

Drugs for Temporal Lobe Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cell-based therapeutics:

Cochrane evidence based reviews: epilepsy, temporal lobe

Genetic Tests for Temporal Lobe Epilepsy

Anatomical Context for Temporal Lobe Epilepsy

Organs/tissues related to Temporal Lobe Epilepsy:

Publications for Temporal Lobe Epilepsy

Articles related to Temporal Lobe Epilepsy:

Genes for Temporal Lobe Epilepsy

Genes related to Temporal Lobe Epilepsy (0 elite genes):

Variations for Temporal Lobe Epilepsy

Expression for Temporal Lobe Epilepsy

Pathways for Temporal Lobe Epilepsy

Pathways related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

GO Terms for Temporal Lobe Epilepsy

Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

Sources for Temporal Lobe Epilepsy

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :