Aliases & Classifications for Temporal Lobe Epilepsy

MalaCards integrated aliases for Temporal Lobe Epilepsy:

Name: Temporal Lobe Epilepsy 38 12 15
Epilepsy, Temporal Lobe 12 44 73
Epilepsy Temporal Lobe 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3328
MeSH 44 D004833
UMLS 73 C0014556

Summaries for Temporal Lobe Epilepsy

MalaCards based summary : Temporal Lobe Epilepsy, also known as epilepsy, temporal lobe, is related to epilepsy, familial temporal lobe, 1 and autosomal dominant epilepsy with auditory features, and has symptoms including seizures An important gene associated with Temporal Lobe Epilepsy is MAP3K14-AS1 (MAP3K14 Antisense RNA 1
Four long non-coding RNA were found to be differentially hypermethylated in temporal lobe epilepsy regardless of hippocampal sclerosis grade.These were urothelial cancer associated 1 (non-protein coding,UCA1),adenosine deaminase,RNA-specific,B2,antisense RNA 1 (ADARB2-AS1),long intergenic non-protein coding RNA 324 (LINC324) and mitogen-activated protein kinase 14,antisense RNA 1(MAP3K14-AS1).
Dysfunction Pattern: Expression [differentially expressed]), and among its related pathways/superpathways are Peptide ligand-binding receptors and Circadian entrainment. The drugs Citalopram and Amitriptyline have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and amygdala, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system characterized by recurrent,... more...

Related Diseases for Temporal Lobe Epilepsy

Diseases related to Temporal Lobe Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 epilepsy, familial temporal lobe, 1 33.9 LGI1 RELN
2 autosomal dominant epilepsy with auditory features 33.3 LGI1 RELN
3 depression 31.6 BDNF HTR1A RELN
4 status epilepticus 31.3 BDNF GFAP LGI1 NPY
5 encephalitis 31.2 GFAP LGI1 TSPO
6 anxiety 30.9 BDNF HTR1A NPY TSPO
7 dysembryoplastic neuroepithelial tumor 30.8 GFAP GRIN1
8 mood disorder 30.7 BDNF HTR1A NPY
9 major depressive disorder 30.5 BDNF GAD1 HTR1A NPY
10 psychotic disorder 30.5 BDNF HTR1A RELN
11 epilepsy, idiopathic generalized 30.4 GABBR1 LGI1 SCN1B TSPO
12 alzheimer disease 29.6 BDNF GFAP GRIN1 RELN SLC1A2 SLC1A3
13 schizophrenia 27.8 BDNF GABBR1 GAD1 GRIK1 GRIN1 HTR1A
14 mesial temporal lobe epilepsy with hippocampal sclerosis 12.4
15 benign familial mesial temporal lobe epilepsy 12.2
16 infantile-onset mesial temporal lobe epilepsy with severe cognitive regression 12.2
17 epilepsy, familial temporal lobe, 2 12.2
18 epilepsy, familial temporal lobe, 3 12.2
19 epilepsy, familial temporal lobe, 7 11.9
20 epilepsy, familial temporal lobe, 4 11.8
21 epilepsy, familial temporal lobe, 5 11.7
22 epilepsy, familial temporal lobe, 6 11.7
23 epilepsy, familial temporal lobe, 8 11.7
24 temporal epilepsy, familial 11.7
25 autosomal dominant partial epilepsy with auditory features 11.4
26 epilepsy 11.3
27 epilepsy, familial focal, with variable foci 2 11.2
28 epilepsy, familial focal, with variable foci 3 11.2
29 febrile seizures, familial, 11 11.2
30 lipoid proteinosis of urbach and wiethe 11.1
31 epilepsy, nocturnal frontal lobe, 1 11.1
32 mental retardation, anterior maxillary protrusion, and strabismus 11.1
33 dissociative amnesia 10.8 HTR1A PDYN
34 neonatal hypoxic and ischemic brain injury 10.8 BDNF SLC1A3
35 childhood disintegrative disease 10.7 BDNF LGI1
36 sensory neuropathy type 1 10.7 GABBR1 GABBR2
37 generalized anxiety disorder 10.7 BDNF HTR1A TSPO
38 toxic encephalopathy 10.6 BDNF GFAP SLC1A2
39 dicarboxylic aminoaciduria 10.6 SLC1A2 SLC1A3
40 neuronitis 10.6
41 wernicke encephalopathy 10.6 GFAP SLC1A2 SLC1A3
42 ocular dominance 10.5 BDNF GAD1 GRIN1
43 spinal cord injury 10.5 BDNF GFAP GRIN1
44 febrile seizures 10.4
45 panic disorder 10.4 BDNF HTR1A TSPO
46 leukoencephalopathy, hereditary diffuse, with spheroids 10.3 GFAP SLC1A2
47 amnestic disorder 10.3 BDNF HTR1A LGI1 PDYN TSPO
48 disease of mental health 10.3 BDNF GAD1 HTR1A PDYN RELN
49 cerebritis 10.2
50 aging 10.2

Graphical network of the top 20 diseases related to Temporal Lobe Epilepsy:



Diseases related to Temporal Lobe Epilepsy

Symptoms & Phenotypes for Temporal Lobe Epilepsy

UMLS symptoms related to Temporal Lobe Epilepsy:


seizures

MGI Mouse Phenotypes related to Temporal Lobe Epilepsy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 GRIK1 GRIN1 HTR1A LGI1 NPY PDYN
2 growth/size/body region MP:0005378 10.28 BDNF GABBR1 GABBR2 GAD1 GFAP GRIK1
3 mortality/aging MP:0010768 10.17 GAD1 GFAP GRIN1 HTR1A LGI1 RELN
4 nervous system MP:0003631 10.16 BDNF GABBR1 GABBR2 GAD1 GFAP GRIK1
5 homeostasis/metabolism MP:0005376 10.15 GABBR2 GAD1 GFAP GRIN1 HTR1A NPY
6 no phenotypic analysis MP:0003012 9.7 BDNF GAD1 GRIN1 HTR1A PDYN SCN1B
7 normal MP:0002873 9.65 SV2B TSPO BDNF GAD1 GFAP GRIK1
8 vision/eye MP:0005391 9.23 BDNF GFAP GRIN1 LGI1 RELN SCN1B

Drugs & Therapeutics for Temporal Lobe Epilepsy

Drugs for Temporal Lobe Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4,Not Applicable 59729-33-8 2771
2
Amitriptyline Approved Phase 4 50-48-6 2160
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Perphenazine Approved Phase 4 58-39-9 4748
5 Antidepressive Agents Phase 4,Not Applicable
6 Antidepressive Agents, Second-Generation Phase 4
7 Antiparkinson Agents Phase 4,Not Applicable
8 Autonomic Agents Phase 4
9 Cholinergic Agents Phase 4
10 Cholinergic Antagonists Phase 4
11 Muscarinic Antagonists Phase 4
12 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
13 Neurotransmitter Uptake Inhibitors Phase 4,Not Applicable
14 Parasympatholytics Phase 4
15 Peripheral Nervous System Agents Phase 4
16 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
17 Serotonin Agents Phase 4,Phase 2,Not Applicable
18 Serotonin Uptake Inhibitors Phase 4,Not Applicable
19 Anesthetics Phase 4,Not Applicable
20 Adrenergic Agents Phase 4
21 Amitriptyline, perphenazine drug combination Phase 4
22 Analgesics Phase 4
23 Analgesics, Non-Narcotic Phase 4
24 Anesthetics, Local Phase 4
25 Anti-Arrhythmia Agents Phase 4
26 Antidepressive Agents, Tricyclic Phase 4
27 Antipsychotic Agents Phase 4
28 Central Nervous System Depressants Phase 4,Phase 2
29 Diuretics, Potassium Sparing Phase 4
30 Sodium Channel Blockers Phase 4
31 Tranquilizing Agents Phase 4,Phase 2
32
Serotonin Investigational, Nutraceutical Phase 4,Phase 2,Not Applicable 50-67-9 5202
33 Anticonvulsants Phase 3,Not Applicable
34
Buspirone Approved, Investigational Phase 2 36505-84-7 2477
35 Naluzotan Investigational Phase 2 740873-06-7
36 Anti-Anxiety Agents Phase 2
37 Serotonin 5-HT1 Receptor Agonists Phase 2
38
Sertraline Approved Not Applicable 79617-96-2 68617
39
Menthol Approved Not Applicable 2216-51-5 16666
40
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
41
Memantine Approved, Investigational Not Applicable 19982-08-2 4054
42
Glutamic Acid Approved, Nutraceutical 56-86-0 33032
43 Fluorides
44 Fluorodeoxyglucose F18
45 Dopamine Agents Not Applicable
46 Excitatory Amino Acid Antagonists Not Applicable
47 Excitatory Amino Acids Not Applicable
48 Krestin

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy Completed NCT00595699 Phase 4 escitalopram;placebo
2 Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines Enrolling by invitation NCT02090998 Phase 4 Amitriptyline
3 Early Surgical Intervention to Treat Epilepsy Completed NCT00040326 Phase 3 antiepileptic drugs
4 A Multicenter Study of Hippocampal Electrical Stimulation (HS, in Mesial Temporal Lobe Epilepsy Terminated NCT00717431 Phase 3
5 Buspirone Therapy for Localized Epilepsy Terminated NCT01496612 Phase 2 Buspirone
6 PRX-00023 Therapy in Localization-Related Epilepsy Terminated NCT01281956 Phase 2 PRX-00023
7 Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy Completed NCT00916266 Phase 1
8 Efficacy of TDCS for Treating Working Memory Dysfunction and Depression in Temporal Lobe Epilepsy Withdrawn NCT02268578 Phase 1
9 Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe Epilepsy Unknown status NCT02151175 Not Applicable
10 Controlled Randomized Vagus Nerve Stimulation (VNS) Therapy Versus Resection (CoRaVNStiR) Unknown status NCT02089243 Not Applicable
11 Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery Unknown status NCT02590419 Not Applicable
12 Controlled Randomized Stimulation Versus Resection (CoRaStiR) Unknown status NCT00431457 Not Applicable
13 Emotional Processing and Memory Evaluation in Epilepsy Patients Unknown status NCT00486239 Early Phase 1
14 Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy Completed NCT01563627 Not Applicable
15 Study of [11C]DPA-713 for Temporal Lobe Epilepsy Completed NCT01793532
16 CBT Versus Selective Serotonin Reuptake Inhibitor For Treatment Of Depression In Temporal Lobe Epilepsy Patients Completed NCT02262156 Not Applicable SSRI
17 Language and Emotional Function in Patients With Temporal Lobe Epilepsy Completed NCT00081432
18 GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression Completed NCT00931619
19 Radiosurgery or Open Surgery for Epilepsy Trial Completed NCT00860145 Not Applicable
20 Electrical Brain Stimulation to Reduce Epileptic Seizures Completed NCT00344877
21 Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy Completed NCT01772654 Not Applicable
22 Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery Completed NCT03102957 Not Applicable
23 Does Memantine Improve Verbal Memory Task Performance in Subjects With Partial Epilepsy and Memory Dysfunction? Completed NCT01054599 Not Applicable Memantine;Memantine
24 Neocortical Epilepsies - Do They Progress? Completed NCT00610558 Not Applicable
25 Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery Completed NCT01285921 Not Applicable
26 Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy Completed NCT00001672
27 Brain P-gp and Inflammation in People With Epilepsy Completed NCT01663545
28 Light Scattering Spectroscopy to Determine Brain Tumors Completed NCT00067418
29 fMRI Guided TMS Enhancement of Associative Memory Networks Completed NCT02749422 Not Applicable
30 Language Mapping in Patients With Epilepsy Completed NCT00706160
31 Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE) Recruiting NCT02383407 Not Applicable
32 Stereotactic Laser Ablation for Temporal Lobe Epilepsy Recruiting NCT02844465 Not Applicable
33 Subcutaneous EEG in Epilepsy Recruiting NCT02946151 Not Applicable
34 Evaluation of Stress Sensitivity and Hyperemotivity in Epilepsy Compared to and a Group of Healthy Volunteers Recruiting NCT03464370 Not Applicable
35 Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation Recruiting NCT02339376 Not Applicable
36 Surgery as a Treatment for Medically Intractable Epilepsy Recruiting NCT01273129
37 Brain Network Activation Analysis in Epilepsy Recruiting NCT03265925
38 Investigating Epilepsy: Screening, Evaluation and Treatment Recruiting NCT03478852
39 Feasibility Study on LITT for Medical Refractory Epilepsy Active, not recruiting NCT02820740 Not Applicable
40 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Active, not recruiting NCT02796287 Not Applicable
41 COMETE Study : COgnitive Rehabilitation of MEmory in Temporal Epilepsy Not yet recruiting NCT02589470 Not Applicable
42 Emotion Recognition in Benign Epilepsy of Childhood With Centro-Temporal Spikes (BECTS) Not yet recruiting NCT03465566
43 Near Death Experience (NDE) and Migraine Not yet recruiting NCT02854930
44 Evaluation and Treatment of Patients With Epilepsy Terminated NCT00013845
45 The Utility of NIOM During LITT for Refractory MTLE Withdrawn NCT02913742 Not Applicable
46 Efficacy and Safety of the Use of Memantine for Preserving Cognition in Adult Patients With Epilepsy Withdrawn NCT00986115 Not Applicable Memantine;Placebo

Search NIH Clinical Center for Temporal Lobe Epilepsy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Temporal Lobe Epilepsy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Temporal Lobe Epilepsy:
Autologous bone marrow-derived mononuclear stem cells for treatment of temporal lobe epilepsy
Embryonic/Adult Cultured Cells Related to Temporal Lobe Epilepsy:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: epilepsy, temporal lobe

Genetic Tests for Temporal Lobe Epilepsy

Anatomical Context for Temporal Lobe Epilepsy

MalaCards organs/tissues related to Temporal Lobe Epilepsy:

41
Temporal Lobe, Brain, Amygdala, Cortex, Bone, Bone Marrow, Testes

Publications for Temporal Lobe Epilepsy

Articles related to Temporal Lobe Epilepsy:

(show top 50) (show all 1082)
# Title Authors Year
1
SPECT perfusion changes during ictal automatisms with preserved responsiveness in patients with right temporal lobe epilepsy. ( 29396356 )
2018
2
Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy. ( 29934763 )
2018
3
Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 29247965 )
2018
4
Widespread abnormalities in white matter integrity and their relationship with duration of illness in temporal lobe epilepsy. ( 29881803 )
2018
5
[<sup>18</sup>F]GE180 positron emission tomographic imaging indicates a potential double-hit insult in the intrahippocampal kainate mouse model of temporal lobe epilepsy. ( 29364511 )
2018
6
Whole-exome sequencing to disentangle the complex genetics of hippocampal sclerosis-temporal lobe epilepsy. ( 29904719 )
2018
7
Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder? ( 29414551 )
2018
8
Rare variants and de novo variants in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 29904720 )
2018
9
Increased cardiac stiffness is associated with autonomic dysfunction in patients with temporal lobe epilepsy. ( 29697139 )
2018
10
Abnormal default-mode network homogeneity in patients with temporal lobe epilepsy. ( 29952987 )
2018
11
MR Fingerprinting: An Advance for Patients with Temporal Lobe Epilepsy. ( 29916775 )
2018
12
Temporal lobe encephalocele, a subtle structural lesion that can be associated with temporal lobe epilepsy. ( 29525398 )
2018
13
Intracranial electrodes monitoring improves seizure control and complication outcomes for patients with temporal lobe epilepsy - A retrospective cohort study. ( 29360612 )
2018
14
Stereotactic Laser Amygdalohippocampotomy for Mesial Temporal Lobe Epilepsy. ( 29420840 )
2018
15
Pharmaco-genetic therapeutics targeting parvalbumin neurons attenuate temporal lobe epilepsy. ( 29894753 )
2018
16
The relationship between structural MRI, FDG-PET, and memory in temporal lobe epilepsy: Preliminary results. ( 29414560 )
2018
17
Seizure outcome in pediatric medically refractory temporal lobe epilepsy surgery: selective amygdalohippocampectomy versus anterior temporal lobectomy. ( 29932370 )
2018
18
The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy. ( 29881945 )
2018
19
Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis. ( 29651571 )
2018
20
Laser ablation is effective for temporal lobe epilepsy with and without mesial temporal sclerosis if hippocampal seizure onsets are localized by stereoelectroencephalography. ( 29392715 )
2018
21
Altered spontaneous brain activity in MRI-negative refractory temporal lobe epilepsy patients with major depressive disorder: A resting-state fMRI study. ( 29406962 )
2018
22
Alterations of theta oscillation in executive control in temporal lobe epilepsy patients. ( 29358157 )
2018
23
Long-Term Electroclinical and Employment Follow up in Temporal Lobe Epilepsy Surgery. A Cuban Comprehensive Epilepsy Surgery Program. ( 29389846 )
2018
24
Surgical Management and Long-Term Seizure Outcome After Surgery for Temporal Lobe Epilepsy Associated with Cerebral Cavernous Malformations. ( 29175574 )
2018
25
Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy. ( 29884458 )
2018
26
Temporal Lobe Epilepsy, Stroke, and Traumatic Brain Injury: Mechanisms of Hyperpolarized, Depolarized, and Flow-Through Ion Channels Utilized as Tri-Coordinate Biomarkers of Electrophysiologic Dysfunction. ( 29951646 )
2018
27
Echocardiographic risk markers of sudden death in patients with temporal lobe epilepsy. ( 29414527 )
2018
28
Follow-Up of Peripheral IL-1I^ and IL-6 and Relation with Apoptotic Death in Drug-Resistant Temporal Lobe Epilepsy Patients Submitted to Surgery. ( 29401729 )
2018
29
Unique and shared areas of cognitive function in children with intractable frontal or temporal lobe epilepsy. ( 29414546 )
2018
30
Changes in resting-state connectivity in pediatric temporal lobe epilepsy. ( 29932365 )
2018
31
Impaired spatial pattern separation performance in temporal lobe epilepsy is associated with visuospatial memory deficits and hippocampal volume loss. ( 29428769 )
2018
32
Memory loss and memory reorganization patterns in temporal lobe epilepsy patients undergoing anterior temporal lobe resection, as demonstrated by pre-versus post-operative functional MRI. ( 29934057 )
2018
33
Reduction of ipsilateral thalamic volume in temporal lobe epilepsy with hippocampal sclerosis. ( 29958756 )
2018
34
Left temporal lobe language network connectivity in temporal lobe epilepsy. ( 29939211 )
2018
35
Detection of Lesions in Mesial Temporal Lobe Epilepsy by Using MR Fingerprinting. ( 29916782 )
2018
36
Amygdala enlargement and emotional responses in (autoimmune) temporal lobe epilepsy. ( 29934574 )
2018
37
High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy. ( 29428937 )
2018
38
SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy. ( 29363864 )
2018
39
Laser ablation for mesial temporal lobe epilepsy: Surgical and cognitive outcomes with and without mesial temporal sclerosis. ( 29893987 )
2018
40
Topographic principles of cortical fluid-attenuated inversion recovery signal in temporal lobe epilepsy. ( 29383717 )
2018
41
SEEG-guided radiofrequency coagulation (SEEG-guided RF-TC) versus anterior temporal lobectomy (ATL) in temporal lobe epilepsy. ( 29943202 )
2018
42
Parahippocampal Involvement in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: A Proof of Concept from Memory-Guided Saccades. ( 29163352 )
2017
43
Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy. ( 28795432 )
2017
44
Decline in word-finding: The objective cognitive finding most relevant to patients after mesial temporal lobe epilepsy surgery. ( 28867574 )
2017
45
MicroRNA and mesial temporal lobe epilepsy with hippocampal sclerosis: Whole miRNome profiling of human hippocampus. ( 28815576 )
2017
46
Pharmacoresistance with newer anti-epileptic drugs in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 28941835 )
2017
47
Tyrosine receptor kinase B gene variants (NTRK2 variants) are associated with depressive disorders in temporal lobe epilepsy. ( 28550723 )
2017
48
Deep brain stimulation for refractory temporal lobe epilepsy: a systematic review and meta-analysis with an emphasis on alleviation of seizure frequency outcome. ( 28921161 )
2017
49
Sex differences in verbal and nonverbal learning before and after temporal lobe epilepsy surgery. ( 28033547 )
2017
50
Comparing CAT12 and VBM8 for Detecting Brain Morphological Abnormalities in Temporal Lobe Epilepsy. ( 28883807 )
2017

Variations for Temporal Lobe Epilepsy

Expression for Temporal Lobe Epilepsy

Search GEO for disease gene expression data for Temporal Lobe Epilepsy.

Pathways for Temporal Lobe Epilepsy

Pathways related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.36 GABBR1 GABBR2 GRIK1 GRIN1 HTR1A NPY
2
Show member pathways
12.8 GABBR1 GABBR2 GRIK1 GRIN1 SLC1A2 SLC1A3
3
Show member pathways
12.72 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 SLC1A2
4 11.92 BDNF GRIN1 HTR1A SLC1A3
5 11.86 GABBR1 GABBR2 GAD1 GFAP GRIN1 HTR1A
6
Show member pathways
11.81 GABBR1 GABBR2 HTR1A
7
Show member pathways
11.78 BDNF GRIN1 PDYN
8
Show member pathways
11.76 GRIN1 SLC1A2 SLC1A3
9 11.75 BDNF GFAP GRIN1 PDYN
10
Show member pathways
11.74 BDNF GABBR1 GABBR2 GRIN1 HTR1A NPY
11 11.46 BDNF GAD1 GFAP SLC1A3
12 11.4 BDNF GAD1 GRIN1
13 10.71 GABBR1 GABBR2
14 10.56 GABBR1 GABBR2 GAD1
15
Show member pathways
10.38 SLC1A2 SLC1A3

GO Terms for Temporal Lobe Epilepsy

Cellular components related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 GABBR1 GABBR2 GRIK1 GRIN1 HTR1A SLC1A2
2 cell junction GO:0030054 9.73 GABBR1 GABBR2 GRIK1 GRIN1 LGI1 SV2B
3 postsynaptic membrane GO:0045211 9.62 GABBR1 GABBR2 GRIK1 GRIN1
4 synaptic vesicle GO:0008021 9.61 BDNF GRIN1 SV2B
5 dendrite GO:0030425 9.43 BDNF GABBR1 GRIN1 HTR1A PDYN RELN
6 synapse GO:0045202 9.17 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 LGI1
7 G-protein coupled receptor heterodimeric complex GO:0038039 9.16 GABBR1 GABBR2
8 plasma membrane GO:0005886 10.15 GABBR1 GABBR2 GAD1 GRIK1 GRIN1 HTR1A

Biological processes related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.85 GRIK1 GRIN1 SCN1B SLC1A2 SLC1A3 TSPO
2 response to drug GO:0042493 9.84 GAD1 SLC1A2 SLC1A3 TSPO
3 axon guidance GO:0007411 9.71 BDNF LGI1 RELN SCN1B
4 response to wounding GO:0009611 9.63 GFAP SLC1A2 SLC1A3
5 cerebral cortex development GO:0021987 9.61 GRIN1 NPY RELN
6 positive regulation of excitatory postsynaptic potential GO:2000463 9.58 GRIN1 RELN
7 ionotropic glutamate receptor signaling pathway GO:0035235 9.57 GRIK1 GRIN1
8 positive regulation of synaptic transmission GO:0050806 9.56 LGI1 SLC1A3
9 response to pain GO:0048265 9.55 RELN TSPO
10 L-glutamate transmembrane transport GO:0015813 9.52 SLC1A2 SLC1A3
11 locomotion GO:0040011 9.51 BDNF SCN1B
12 positive regulation of glial cell proliferation GO:0060252 9.49 GFAP TSPO
13 regulation of behavior GO:0050795 9.48 HTR1A RELN
14 modulation of chemical synaptic transmission GO:0050804 9.33 BDNF GRIK1 RELN
15 L-glutamate import across plasma membrane GO:0098712 9.32 SLC1A2 SLC1A3
16 chemical synaptic transmission GO:0007268 9.32 GABBR2 GAD1 GRIK1 HTR1A NPY PDYN
17 D-aspartate import across plasma membrane GO:0070779 9.26 SLC1A2 SLC1A3
18 gamma-aminobutyric acid biosynthetic process GO:0009449 8.96 GAD1 SLC1A3

Molecular functions related to Temporal Lobe Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 9.43 GRIK1 GRIN1
2 ionotropic glutamate receptor activity GO:0004970 9.4 GRIK1 GRIN1
3 extracellularly glutamate-gated ion channel activity GO:0005234 9.37 GRIK1 GRIN1
4 L-glutamate transmembrane transporter activity GO:0005313 9.32 SLC1A2 SLC1A3
5 high-affinity glutamate transmembrane transporter activity GO:0005314 9.26 SLC1A2 SLC1A3
6 glutamate:sodium symporter activity GO:0015501 9.16 SLC1A2 SLC1A3
7 G-protein coupled GABA receptor activity GO:0004965 8.96 GABBR1 GABBR2
8 glutamate binding GO:0016595 8.8 GAD1 GRIN1 SLC1A3

Sources for Temporal Lobe Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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