MCID: TMP002
MIFTS: 27

Temporal Lobe Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Temporal Lobe Neoplasm

MalaCards integrated aliases for Temporal Lobe Neoplasm:

Name: Temporal Lobe Neoplasm 12 15
Neoplasm of Temporal Lobe 12 71
Malignant Neoplasm of Temporal Lobe 12
Tumor of Temporal Lobe 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2135
ICD9CM 34 191.2
NCIt 50 C5567
SNOMED-CT 67 126955002 94086000
ICD10 32 C71.2
UMLS 71 C0153636 C1263887

Summaries for Temporal Lobe Neoplasm

MalaCards based summary : Temporal Lobe Neoplasm, also known as neoplasm of temporal lobe, is related to uterine sarcoma and colchicine resistance. An important gene associated with Temporal Lobe Neoplasm is FUBP1 (Far Upstream Element Binding Protein 1), and among its related pathways/superpathways are Glucose / Energy Metabolism and HIF-1-alpha transcription factor network. Affiliated tissues include temporal lobe, brain and eye, and related phenotypes are mortality/aging and nervous system

Related Diseases for Temporal Lobe Neoplasm

Diseases related to Temporal Lobe Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 uterine sarcoma 10.1 ABCC1 ABCB1
2 colchicine resistance 10.1 ABCC1 ABCB1
3 adult oligodendroglioma 10.1 IDH1 FUBP1
4 microsporidiosis 10.1 ABCC1 ABCB1
5 cholangiolocellular carcinoma 10.0 ABCC1 ABCB1
6 adult brain stem glioma 10.0 MGMT IDH1
7 frontal lobe neoplasm 10.0 MGMT IDH1
8 gemistocytic astrocytoma 10.0 IDH1 ATRX
9 spinal cord astrocytoma 10.0 MGMT IDH1
10 childhood brain stem glioma 10.0 IDH1 ATRX
11 high-grade astrocytoma 10.0 IDH1 ATRX
12 adult astrocytic tumour 10.0 IDH1 ATRX
13 seizure disorder 10.0
14 pik3ca-related overgrowth syndrome 10.0
15 multiple enchondromatosis, maffucci type 10.0 IDH1 ATRX
16 frontal convexity meningioma 9.9 TERT IDH1
17 gliofibroma 9.9 MGMT IDH1
18 germinoma 9.9 ABCC1 ABCB1
19 high grade ependymoma 9.9 MGMT IDH1
20 supratentorial cancer 9.9 MGMT IDH1
21 enchondromatosis, multiple, ollier type 9.9 IDH1 ATRX
22 central nervous system benign neoplasm 9.8 IDH1 ATRX
23 spinal cord oligodendroglioma 9.8 MGMT IDH1 ATRX
24 cerebral ventricle cancer 9.8 MGMT IDH1 ATRX
25 cerebrum cancer 9.8 MGMT IDH1 ATRX
26 pleomorphic xanthoastrocytoma 9.8 MGMT IDH1 ATRX
27 diffuse midline glioma, h3 k27m-mutant 9.8 MGMT IDH1 ATRX
28 giant cell glioblastoma 9.8 MGMT IDH1 ATRX
29 anaplastic astrocytoma 9.8 MGMT IDH1 ATRX
30 spinal disease 9.8 MGMT IDH1 ATRX
31 central nervous system cancer 9.7 MGMT IDH1 ATRX
32 pilomyxoid astrocytoma 9.7 IDH1 ATRX
33 osteogenic sarcoma 9.7 ATRX ABCC1 ABCB1
34 li-fraumeni syndrome 9.7 TERT IDH1 ATRX
35 high grade glioma 9.7 TERT MGMT ABCB1
36 lung benign neoplasm 9.7 TERT MGMT
37 childhood oligodendroglioma 9.6 MGMT IDH1 FUBP1 ATRX
38 mixed glioma 9.6 MGMT IDH1 FUBP1 ATRX
39 breast adenocarcinoma 9.6 MGMT IDH1 ABCB1
40 brain glioma 9.6 MGMT IDH1 FUBP1 ATRX
41 low grade glioma 9.6 MGMT MAPT IDH1
42 brain cancer 9.5 MGMT IDH1 ABCB1
43 mixed oligodendroglioma-astrocytoma 9.5 TERT MGMT IDH1 ATRX
44 pilocytic astrocytoma 9.5 MGMT IDH1 ATRX ABCB1
45 gliosarcoma 9.5 TERT MGMT IDH1 ATRX
46 thrombocytopenia 9.5 TERT MGMT F10 ABCB1
47 lung cancer susceptibility 3 9.5 TERT IDH1 ABCC1 ABCB1
48 leukemia, acute myeloid 9.4 TERT IDH1 ABCC1 ABCB1
49 diffuse astrocytoma 9.3 TERT MGMT IDH1 FUBP1 ATRX
50 oligodendroglioma 9.3 TERT MGMT IDH1 FUBP1 ATRX

Graphical network of the top 20 diseases related to Temporal Lobe Neoplasm:



Diseases related to Temporal Lobe Neoplasm

Symptoms & Phenotypes for Temporal Lobe Neoplasm

MGI Mouse Phenotypes related to Temporal Lobe Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.61 ABCB1 ABCC1 ATRX F10 FUBP1 IDH1
2 nervous system MP:0003631 9.17 ABCB1 ABCC1 ATRX FUBP1 MAPT MGMT

Drugs & Therapeutics for Temporal Lobe Neoplasm

Search Clinical Trials , NIH Clinical Center for Temporal Lobe Neoplasm

Genetic Tests for Temporal Lobe Neoplasm

Anatomical Context for Temporal Lobe Neoplasm

MalaCards organs/tissues related to Temporal Lobe Neoplasm:

40
Temporal Lobe, Brain, Eye

Publications for Temporal Lobe Neoplasm

Articles related to Temporal Lobe Neoplasm:

# Title Authors PMID Year
1
Emergent use of an MRI-conditional external pacemaker in a patient with sinus arrest facilitating diagnosis of a temporal lobe neoplasm. 61
28491694 2016
2
Temporal lobe neoplasm and seizures: how deep does the story go? 61
18367435 2008
3
Electro-clinical characteristics and postoperative outcome of medically refractory tumoral temporal lobe epilepsy. 61
15805659 2005
4
Exacerbation of mania secondary to right temporal lobe astrocytoma in a bipolar patient previously stabilized on valproate. 61
14665823 2003
5
[Coexistence of aneurysm of the right posterior communicating artery and a right temporal lobe neoplasm]. 61
4407722 1974

Variations for Temporal Lobe Neoplasm

Expression for Temporal Lobe Neoplasm

Search GEO for disease gene expression data for Temporal Lobe Neoplasm.

Pathways for Temporal Lobe Neoplasm

GO Terms for Temporal Lobe Neoplasm

Biological processes related to Temporal Lobe Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.58 MGMT ABCC1 ABCB1
2 DNA methylation GO:0006306 9.37 MGMT ATRX
3 phospholipid translocation GO:0045332 9.32 ABCC1 ABCB1
4 export across plasma membrane GO:0140115 9.26 ABCC1 ABCB1
5 transepithelial transport GO:0070633 9.16 ABCC1 ABCB1
6 carboxylic acid transmembrane transport GO:1905039 8.96 ABCC1 ABCB1
7 lactone transport GO:0042969 8.62 ABCC1 ABCB1

Molecular functions related to Temporal Lobe Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.37 ABCC1 ABCB1
2 xenobiotic transmembrane transporter activity GO:0042910 9.32 ABCC1 ABCB1
3 efflux transmembrane transporter activity GO:0015562 9.26 ABCC1 ABCB1
4 xenobiotic transmembrane transporting ATPase activity GO:0008559 9.16 ABCC1 ABCB1
5 carboxylic acid transmembrane transporter activity GO:0046943 8.96 ABCC1 ABCB1
6 lactone transmembrane transporter activity GO:0042971 8.62 ABCC1 ABCB1

Sources for Temporal Lobe Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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