MCID: TMP002
MIFTS: 28

Temporal Lobe Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Temporal Lobe Neoplasm

MalaCards integrated aliases for Temporal Lobe Neoplasm:

Name: Temporal Lobe Neoplasm 12 15
Neoplasm of Temporal Lobe 12 71
Malignant Neoplasm of Temporal Lobe 12
Tumor of Temporal Lobe 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2135
ICD9CM 34 191.2
NCIt 49 C5567
SNOMED-CT 67 94086000
ICD10 32 C71.2
UMLS 71 C0153636 C1263887

Summaries for Temporal Lobe Neoplasm

MalaCards based summary : Temporal Lobe Neoplasm, also known as neoplasm of temporal lobe, is related to uterine sarcoma and colchicine resistance. An important gene associated with Temporal Lobe Neoplasm is TENM3 (Teneurin Transmembrane Protein 3), and among its related pathways/superpathways are Doxorubicin Pathway, Pharmacokinetics and Constitutive Androstane Receptor Pathway. Affiliated tissues include temporal lobe, brain and eye, and related phenotypes are mortality/aging and nervous system

Related Diseases for Temporal Lobe Neoplasm

Diseases related to Temporal Lobe Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 uterine sarcoma 10.2 ABCC1 ABCB1
2 colchicine resistance 10.1 ABCC1 ABCB1
3 microsporidiosis 10.1 ABCC1 ABCB1
4 cholangiolocellular carcinoma 10.1 ABCC1 ABCB1
5 adult brain stem glioma 10.1 MGMT IDH1
6 frontal lobe neoplasm 10.1 MGMT IDH1
7 spinal cord astrocytoma 10.0 MGMT IDH1
8 adult astrocytic tumour 10.0 IDH1 ATRX
9 gemistocytic astrocytoma 10.0 MGMT IDH1
10 glioblastoma classical subtype 10.0 MGMT IDH1
11 malignant ependymoma 9.9 MGMT IDH1
12 soft tissue sarcoma 9.9 FOXO1 ABCB1
13 supratentorial cancer 9.9 MGMT IDH1
14 adult oligodendroglioma 9.9 IDH1 FUBP1 ATRX
15 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
16 visual epilepsy 9.9
17 seizure disorder 9.9
18 pik3ca-related overgrowth syndrome 9.9
19 pleomorphic xanthoastrocytoma 9.9 MGMT IDH1
20 enchondromatosis, multiple, ollier type 9.9 IDH1 ATRX
21 temporal lobe epilepsy 9.9
22 brain glioma 9.8 MGMT IDH1 FUBP1
23 spinal cord oligodendroglioma 9.8 MGMT IDH1 ATRX
24 cerebral ventricle cancer 9.8 MGMT IDH1 ATRX
25 cerebrum cancer 9.8 MGMT IDH1 ATRX
26 brain stem glioma 9.8 MGMT IDH1 ATRX
27 giant cell glioblastoma 9.8 MGMT IDH1 ATRX
28 grade iii astrocytoma 9.8 MGMT IDH1 ATRX
29 central nervous system cancer 9.7 MGMT IDH1 ATRX
30 frontal convexity meningioma 9.7 TERT IDH1
31 central nervous system rhabdomyosarcoma 9.6 MGMT IDH1 FOXO1
32 childhood oligodendroglioma 9.6 MGMT IDH1 FUBP1 ATRX
33 osteogenic sarcoma 9.6 ATRX ABCC1 ABCB1
34 mixed glioma 9.6 MGMT IDH1 FUBP1 ATRX
35 juvenile pilocytic astrocytoma 9.6 MGMT IDH1
36 breast adenocarcinoma 9.5 MGMT IDH1 ABCB1
37 gliosarcoma 9.2 TERT MGMT IDH1 ATRX
38 meningioma, familial 9.2 TERT MGMT IDH1 ATRX
39 bladder urothelial carcinoma 9.1 TERT IDH1 ABCC1
40 brain cancer 9.0 TERT MGMT IDH1 ABCB1
41 fibrillary astrocytoma 9.0 TERT MGMT IDH1 FUBP1 ATRX
42 oligodendroglioma 9.0 TERT MGMT IDH1 FUBP1 ATRX
43 lung cancer susceptibility 3 8.8 TERT MGMT IDH1 ABCC1 ABCB1
44 myelodysplastic syndrome 8.8 TERT MGMT IDH1 ATRX ABCB1
45 neuroblastoma 8.8 TERT MAPT ATRX ABCC1 ABCB1
46 leukemia, acute myeloid 8.7 TERT IDH1 FOXO1 ABCC1 ABCB1
47 medulloblastoma 8.6 TERT MGMT IDH1 FOXO1 ABCB1
48 glioblastoma multiforme 8.1 TERT MGMT IDH1 FOXO1 ATRX ABCC1

Graphical network of the top 20 diseases related to Temporal Lobe Neoplasm:



Diseases related to Temporal Lobe Neoplasm

Symptoms & Phenotypes for Temporal Lobe Neoplasm

MGI Mouse Phenotypes related to Temporal Lobe Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.7 ABCB1 ABCC1 ATRX F10 FOXO1 FUBP1
2 nervous system MP:0003631 9.28 ABCB1 ABCC1 ATRX FOXO1 FUBP1 MAPT

Drugs & Therapeutics for Temporal Lobe Neoplasm

Search Clinical Trials , NIH Clinical Center for Temporal Lobe Neoplasm

Genetic Tests for Temporal Lobe Neoplasm

Anatomical Context for Temporal Lobe Neoplasm

MalaCards organs/tissues related to Temporal Lobe Neoplasm:

40
Temporal Lobe, Brain, Eye, Spinal Cord, Lung, Breast, Myeloid

Publications for Temporal Lobe Neoplasm

Articles related to Temporal Lobe Neoplasm:

# Title Authors PMID Year
1
Emergent use of an MRI-conditional external pacemaker in a patient with sinus arrest facilitating diagnosis of a temporal lobe neoplasm. 61
28491694 2016
2
Temporal lobe neoplasm and seizures: how deep does the story go? 61
18367435 2008
3
Electro-clinical characteristics and postoperative outcome of medically refractory tumoral temporal lobe epilepsy. 61
15805659 2005
4
Exacerbation of mania secondary to right temporal lobe astrocytoma in a bipolar patient previously stabilized on valproate. 61
14665823 2003
5
[Coexistence of aneurysm of the right posterior communicating artery and a right temporal lobe neoplasm]. 61
4407722 1974

Variations for Temporal Lobe Neoplasm

Expression for Temporal Lobe Neoplasm

Search GEO for disease gene expression data for Temporal Lobe Neoplasm.

Pathways for Temporal Lobe Neoplasm

GO Terms for Temporal Lobe Neoplasm

Biological processes related to Temporal Lobe Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid translocation GO:0045332 9.26 ABCC1 ABCB1
2 DNA methylation GO:0006306 9.16 MGMT ATRX
3 transepithelial transport GO:0070633 8.96 ABCC1 ABCB1
4 export across plasma membrane GO:0140115 8.62 ABCC1 ABCB1

Molecular functions related to Temporal Lobe Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.85 TERT MGMT MAPT FUBP1 FOXO1 ATRX
2 protein phosphatase 2A binding GO:0051721 9.32 MAPT FOXO1
3 transcription coactivator binding GO:0001223 9.26 TERT FOXO1
4 xenobiotic transmembrane transporter activity GO:0042910 9.16 ABCC1 ABCB1
5 efflux transmembrane transporter activity GO:0015562 8.96 ABCC1 ABCB1
6 xenobiotic transmembrane transporting ATPase activity GO:0008559 8.62 ABCC1 ABCB1

Sources for Temporal Lobe Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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