Temporal Lobe Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Temporal Lobe Neoplasm

MalaCards integrated aliases for Temporal Lobe Neoplasm:

Name: Temporal Lobe Neoplasm ¹² ¹⁵

Neoplasm of Temporal Lobe ¹² ⁷¹

Malignant Neoplasm of Temporal Lobe ¹²

Tumor of Temporal Lobe ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Malignant neoplasms of eye, brain and other parts of central nervous system

Malignant neoplasm of brain

Malignant neoplasm: Temporal lobe

External Ids:

Disease Ontology ¹² DOID:2135

ICD9CM ³⁴ 191.2

NCIt ⁵⁰ C5567

SNOMED-CT ⁶⁷ 126955002 94086000

ICD10 ³² C71.2

UMLS ⁷¹ C0153636 C1263887

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Summaries for Temporal Lobe Neoplasm

MalaCards based summary : Temporal Lobe Neoplasm, also known as neoplasm of temporal lobe, is related to uterine sarcoma and colchicine resistance. An important gene associated with Temporal Lobe Neoplasm is FUBP1 (Far Upstream Element Binding Protein 1), and among its related pathways/superpathways are Glucose / Energy Metabolism and HIF-1-alpha transcription factor network. Affiliated tissues include temporal lobe, brain and eye, and related phenotypes are mortality/aging and nervous system

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Related Diseases for Temporal Lobe Neoplasm

Diseases related to Temporal Lobe Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)

#	Related Disease	Score	Top Affiliating Genes
1	uterine sarcoma	10.1	ABCC1 ABCB1
2	colchicine resistance	10.1	ABCC1 ABCB1
3	adult oligodendroglioma	10.1	IDH1 FUBP1
4	microsporidiosis	10.1	ABCC1 ABCB1
5	cholangiolocellular carcinoma	10.0	ABCC1 ABCB1
6	adult brain stem glioma	10.0	MGMT IDH1
7	frontal lobe neoplasm	10.0	MGMT IDH1
8	gemistocytic astrocytoma	10.0	IDH1 ATRX
9	spinal cord astrocytoma	10.0	MGMT IDH1
10	childhood brain stem glioma	10.0	IDH1 ATRX
11	high-grade astrocytoma	10.0	IDH1 ATRX
12	adult astrocytic tumour	10.0	IDH1 ATRX
13	seizure disorder	10.0
14	pik3ca-related overgrowth syndrome	10.0
15	multiple enchondromatosis, maffucci type	10.0	IDH1 ATRX
16	frontal convexity meningioma	9.9	TERT IDH1
17	gliofibroma	9.9	MGMT IDH1
18	germinoma	9.9	ABCC1 ABCB1
19	high grade ependymoma	9.9	MGMT IDH1
20	supratentorial cancer	9.9	MGMT IDH1
21	enchondromatosis, multiple, ollier type	9.9	IDH1 ATRX
22	central nervous system benign neoplasm	9.8	IDH1 ATRX
23	spinal cord oligodendroglioma	9.8	MGMT IDH1 ATRX
24	cerebral ventricle cancer	9.8	MGMT IDH1 ATRX
25	cerebrum cancer	9.8	MGMT IDH1 ATRX
26	pleomorphic xanthoastrocytoma	9.8	MGMT IDH1 ATRX
27	diffuse midline glioma, h3 k27m-mutant	9.8	MGMT IDH1 ATRX
28	giant cell glioblastoma	9.8	MGMT IDH1 ATRX
29	anaplastic astrocytoma	9.8	MGMT IDH1 ATRX
30	spinal disease	9.8	MGMT IDH1 ATRX
31	central nervous system cancer	9.7	MGMT IDH1 ATRX
32	pilomyxoid astrocytoma	9.7	IDH1 ATRX
33	osteogenic sarcoma	9.7	ATRX ABCC1 ABCB1
34	li-fraumeni syndrome	9.7	TERT IDH1 ATRX
35	high grade glioma	9.7	TERT MGMT ABCB1
36	lung benign neoplasm	9.7	TERT MGMT
37	childhood oligodendroglioma	9.6	MGMT IDH1 FUBP1 ATRX
38	mixed glioma	9.6	MGMT IDH1 FUBP1 ATRX
39	breast adenocarcinoma	9.6	MGMT IDH1 ABCB1
40	brain glioma	9.6	MGMT IDH1 FUBP1 ATRX
41	low grade glioma	9.6	MGMT MAPT IDH1
42	brain cancer	9.5	MGMT IDH1 ABCB1
43	mixed oligodendroglioma-astrocytoma	9.5	TERT MGMT IDH1 ATRX
44	pilocytic astrocytoma	9.5	MGMT IDH1 ATRX ABCB1
45	gliosarcoma	9.5	TERT MGMT IDH1 ATRX
46	thrombocytopenia	9.5	TERT MGMT F10 ABCB1
47	lung cancer susceptibility 3	9.5	TERT IDH1 ABCC1 ABCB1
48	leukemia, acute myeloid	9.4	TERT IDH1 ABCC1 ABCB1
49	diffuse astrocytoma	9.3	TERT MGMT IDH1 FUBP1 ATRX
50	oligodendroglioma	9.3	TERT MGMT IDH1 FUBP1 ATRX

Graphical network of the top 20 diseases related to Temporal Lobe Neoplasm:

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Symptoms & Phenotypes for Temporal Lobe Neoplasm

MGI Mouse Phenotypes related to Temporal Lobe Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	9.61	ABCB1 ABCC1 ATRX F10 FUBP1 IDH1
2	nervous system	MP:0003631	9.17	ABCB1 ABCC1 ATRX FUBP1 MAPT MGMT

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Drugs & Therapeutics for Temporal Lobe Neoplasm

Search Clinical Trials , NIH Clinical Center for Temporal Lobe Neoplasm

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Genetic Tests for Temporal Lobe Neoplasm

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Anatomical Context for Temporal Lobe Neoplasm

MalaCards organs/tissues related to Temporal Lobe Neoplasm:

⁴⁰

Temporal Lobe, Brain, Eye

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Publications for Temporal Lobe Neoplasm

Articles related to Temporal Lobe Neoplasm:

#	Title	Authors	PMID	Year
1	Emergent use of an MRI-conditional external pacemaker in a patient with sinus arrest facilitating diagnosis of a temporal lobe neoplasm. ⁶¹	McGuinn EM...Rottman JN	28491694	2016
2	Temporal lobe neoplasm and seizures: how deep does the story go? ⁶¹	Jehi LE...Busch R	18367435	2008
3	Electro-clinical characteristics and postoperative outcome of medically refractory tumoral temporal lobe epilepsy. ⁶¹	Panda S...Sarma SP	15805659	2005
4	Exacerbation of mania secondary to right temporal lobe astrocytoma in a bipolar patient previously stabilized on valproate. ⁶¹	Sokolski KN...Denson TF	14665823	2003
5	[Coexistence of aneurysm of the right posterior communicating artery and a right temporal lobe neoplasm]. ⁶¹	Janicki W...Glaz C	4407722	1974

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Genes for Temporal Lobe Neoplasm

Genes related to Temporal Lobe Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FUBP1	Far Upstream Element Binding Protein 1	Protein Coding	5.22	DISEASES inferred ¹⁵
2	F10	Coagulation Factor X	Protein Coding	4.65	DISEASES inferred ¹⁵
3	ABCC1	ATP Binding Cassette Subfamily C Member 1	Protein Coding	4.38	DISEASES inferred ¹⁵
4	ATRX	ATRX Chromatin Remodeler	Protein Coding	4.18	DISEASES inferred ¹⁵
5	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	3.9	DISEASES inferred ¹⁵
6	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	3.82	DISEASES inferred ¹⁵
7	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	3.79	DISEASES inferred ¹⁵
8	MAPT	Microtubule Associated Protein Tau	Protein Coding	3.69	DISEASES inferred ¹⁵
9	TERT	Telomerase Reverse Transcriptase	Protein Coding	3.67	DISEASES inferred ¹⁵

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Variations for Temporal Lobe Neoplasm

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Expression for Temporal Lobe Neoplasm

Search GEO for disease gene expression data for Temporal Lobe Neoplasm.

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Pathways for Temporal Lobe Neoplasm

Pathways related to Temporal Lobe Neoplasm according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Glucose / Energy Metabolism ⁴	12.12	IDH1 ABCC1 ABCB1
2	HIF-1-alpha transcription factor network ¹	11.31	TERT ABCB1
3	Irinotecan Pathway, Pharmacokinetics ⁶⁰ Show member pathways Irinotecan Pathway ¹ Irinotecan Pathway, Pharmacodynamics ⁶⁰ Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.25	ABCC1 ABCB1
4	Doxorubicin Pathway, Pharmacokinetics ⁶⁰ Show member pathways Doxorubicin Pathway (Cancer Cell), Pharmacodynamics ⁶⁰	11.03	ABCC1 ABCB1
5	Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.77	ABCC1 ABCB1
6	Methotrexate Pathway, Pharmacokinetics ⁶⁰ Show member pathways Methotrexate Pathway (Brain Cell), Pharmacokinetics ⁶⁰	10.67	ABCC1 ABCB1
7	Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.58	ABCC1 ABCB1
8	Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Show member pathways Bosutinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Nilotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Taxane Pathway, Pharmacokinetics ⁶⁰	10.52	MAPT ABCC1 ABCB1
9	Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics ⁶⁰	10.43	ABCC1 ABCB1
10	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.33	ABCC1 ABCB1
11	Vinka Alkaloid Pathway, Pharmacokinetics ⁶⁰	9.96	ABCC1 ABCB1

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GO Terms for Temporal Lobe Neoplasm

Biological processes related to Temporal Lobe Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to drug	GO:0042493	9.58	MGMT ABCC1 ABCB1
2	DNA methylation	GO:0006306	9.37	MGMT ATRX
3	phospholipid translocation	GO:0045332	9.32	ABCC1 ABCB1
4	export across plasma membrane	GO:0140115	9.26	ABCC1 ABCB1
5	transepithelial transport	GO:0070633	9.16	ABCC1 ABCB1
6	carboxylic acid transmembrane transport	GO:1905039	8.96	ABCC1 ABCB1
7	lactone transport	GO:0042969	8.62	ABCC1 ABCB1

Molecular functions related to Temporal Lobe Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATPase activity, coupled to transmembrane movement of substances	GO:0042626	9.37	ABCC1 ABCB1
2	xenobiotic transmembrane transporter activity	GO:0042910	9.32	ABCC1 ABCB1
3	efflux transmembrane transporter activity	GO:0015562	9.26	ABCC1 ABCB1
4	xenobiotic transmembrane transporting ATPase activity	GO:0008559	9.16	ABCC1 ABCB1
5	carboxylic acid transmembrane transporter activity	GO:0046943	8.96	ABCC1 ABCB1
6	lactone transmembrane transporter activity	GO:0042971	8.62	ABCC1 ABCB1

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Sources for Temporal Lobe Neoplasm

¹ BioSystems

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²⁵ GeneReviews

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²⁷ GEO DataSets

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³² ICD10

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⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

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⁶⁹ TGDB

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⁷¹ UMLS

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⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia