Aliases & Classifications for Tendinopathy

MalaCards integrated aliases for Tendinopathy:

Name: Tendinopathy 40 37 17 70

External Ids:

UMLS 70 C1568272

Summaries for Tendinopathy

MalaCards based summary : Tendinopathy is related to tendinosis and clubfoot, and has symptoms including muscle weakness, myalgia and muscle cramp. An important gene associated with Tendinopathy is COL5A1 (Collagen Type V Alpha 1 Chain), and among its related pathways/superpathways are Integrin Pathway and Toll-like Receptor Signaling Pathway. The drugs Polidocanol and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and bone marrow, and related phenotypes are cardiovascular system and immune system

Wikipedia : 73 Tendinopathy, also known as tendinitis or tendonitis, is a type of tendon disorder that results in pain,... more...

Related Diseases for Tendinopathy

Diseases related to Tendinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 tendinosis 32.0 MMP3 MMP1
2 clubfoot 29.3 COL5A1 CASP8 CASP3
3 cerebral palsy 29.2 MMP8 MMP3 MMP1
4 synovitis 29.2 TIMP2 MMP8 MMP3 MMP1
5 tendinitis 11.7
6 cole disease 11.1
7 tenosynovitis 11.0
8 de quervain disease 11.0
9 rapidly involuting congenital hemangioma 10.8
10 epicondylitis 10.6
11 frozen shoulder 10.5
12 bursitis 10.5
13 fasciitis 10.3
14 plantar fasciitis 10.3
15 chronic pain 10.3
16 shoulder impingement syndrome 10.3
17 calcific tendinitis 10.2
18 enthesopathy 10.2
19 superior limbic keratoconjunctivitis 10.1 MMP3 MMP1
20 exostosis 10.1
21 osteoarthritis 10.1
22 coronary artery aneurysm 10.1 MMP3 MMP1
23 spastic entropion 10.1 MMP3 MMP1
24 plica syndrome 10.1
25 gout 10.1
26 caspase 8 deficiency 10.1 COL5A1 CASP8
27 corneal edema 10.1 MMP3 MMP1
28 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
29 periarthritis 10.0
30 arthropathy 10.0
31 periodontitis, chronic 10.0 MMP8 MMP1
32 septic arthritis 10.0 MMP3 MMP1
33 epidermolysis bullosa dystrophica 10.0 MMP3 MMP1
34 periodontitis, aggressive, 1 10.0 MMP8 MMP1
35 pain agnosia 10.0
36 patellar tendinitis 10.0
37 arthritis 10.0
38 diabetes mellitus 10.0
39 47,xyy 10.0
40 48,xyyy 10.0
41 lymph node disease 10.0 MMP3 MMP1
42 gingival disease 10.0 MMP8 MMP1
43 exfoliation syndrome 9.9 MMP3 MMP1
44 chondrocalcinosis 9.9 MMP3 MMP1 ENPP1
45 cowpox 9.9 CASP8 CASP3
46 cutis laxa 9.9 MMP3 MMP1 COL5A1
47 marfan syndrome 9.9 MMP3 MMP1 COL5A1
48 lipodermatosclerosis 9.9 TIMP2 MMP1
49 carpal tunnel syndrome 9.9
50 hypercholesterolemia, familial, 1 9.9

Graphical network of the top 20 diseases related to Tendinopathy:

Diseases related to Tendinopathy

Symptoms & Phenotypes for Tendinopathy

UMLS symptoms related to Tendinopathy:

muscle weakness; myalgia; muscle cramp; muscle rigidity; muscle spasticity

MGI Mouse Phenotypes related to Tendinopathy:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 CASP3 CASP8 COL5A1 ENPP1 MMP8 TIMP2
2 immune system MP:0005387 9.17 CASP3 CASP8 ENPP1 MMP1 MMP3 MMP8

Drugs & Therapeutics for Tendinopathy

Drugs for Tendinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 152)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Polidocanol Approved Phase 4 9002-92-0
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
Etanercept Approved, Investigational Phase 4 185243-69-0
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
Cortisone Experimental Phase 4 53-06-5 222786
12 Protective Agents Phase 4
13 Sclerosing Solutions Phase 4
14 Cyclooxygenase 2 Inhibitors Phase 4
15 Adjuvants, Immunologic Phase 4
16 Viscosupplements Phase 4
17 Gastrointestinal Agents Phase 4
18 Antiemetics Phase 4
19 Antineoplastic Agents, Hormonal Phase 4
Ibuprofen Approved Phase 3 15687-27-1 3672
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
Copper Approved, Investigational Phase 3 7440-50-8 27099
Zinc Approved, Investigational Phase 3 7440-66-6 32051
Ropivacaine Approved Phase 2, Phase 3 84057-95-4 71273 175805
Clonidine Approved Phase 3 4205-90-7 2803
Etodolac Approved, Investigational, Vet_approved Phase 3 41340-25-4 3308
Ketamine Approved, Vet_approved Phase 2, Phase 3 6740-88-1 3821
Glycolic acid Approved, Investigational Phase 3 79-14-1 757
Ketoprofen Approved, Vet_approved Phase 3 22071-15-4 3825
Manganese Approved, Nutraceutical Phase 3 7439-96-5 27854
Glutamic acid Approved, Nutraceutical Phase 2, Phase 3 56-86-0 33032
32 Calcium, Dietary Phase 3
33 Copper Supplement Phase 3
34 Adrenergic alpha-Agonists Phase 3
35 Adrenergic Agonists Phase 3
36 Adrenergic Agents Phase 3
37 Sympathomimetics Phase 3
38 Vasoconstrictor Agents Phase 3
39 Adrenergic beta-Agonists Phase 3
40 Mydriatics Phase 3
41 Antihypertensive Agents Phase 3
42 Bronchodilator Agents Phase 3
43 Sympatholytics Phase 3
44 Mitogens Phase 2, Phase 3
45 Neurotransmitter Agents Phase 2, Phase 3
46 Anesthetics, General Phase 2, Phase 3
47 Anesthetics, Intravenous Phase 2, Phase 3
48 Excitatory Amino Acid Antagonists Phase 2, Phase 3
49 Anesthetics, Dissociative Phase 2, Phase 3
50 Carboxymethylcellulose Sodium Phase 3

Interventional clinical trials:

(show top 50) (show all 288)
# Name Status NCT ID Phase Drugs
1 Insertional Achilles Tendinopathy: A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon Unknown status NCT01341509 Phase 4
2 Functional Improvement and Ultrasound Tissue Characterisation of the Achilles Tendon Following Sodium Hyaluronate Injection for Plantaris Friction Syndrome Unknown status NCT03077009 Phase 4 Hyaluronic Acid
3 The Effect of Platelet Rich Plasma on Partial Thickness Rotator Cuff Tears: A Randomized Controlled Trial Completed NCT04743986 Phase 4 Corticosteroid (CS)
4 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to a Single Intrabursal Injection of Corticosteroids in Patients With Shoulder Calcific Tendinopathy Completed NCT01652495 Phase 4 methylprednisolone acetate;Triamcinolone Acetonide
5 The Value of Platelet-Rich Plasma in Chronic Midportion Achilles Tendinopathy: a Double-blind Randomized Clinical Trial Completed NCT00761423 Phase 4
6 "NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control, Leg Stiffness and Functional Recovery in Athletes" Completed NCT00792376 Phase 4 etoricoxib;diclofenac
7 Placebo Controlled Trial, Testing the Efficacy of Polidocanol Injections as a Treatment of Chronic Achilles Tendinopathy. Completed NCT00377910 Phase 4 Aethoxysclerol
8 The Value of a High-Volume Image-Guided Injection in Chronic Midportion Achilles Tendinopathy: a Double-blind, Randomized, Placebo-controlled Clinical Trial Completed NCT02996409 Phase 4 HVIGI;LVIGI
9 Shockwave Therapy of Chronic Achilles Tendinopathy. A Double-blind, Randomized Clinical Trial of Efficacy Completed NCT00958620 Phase 4
10 Radiofrequency-based Plasma Microdebridement Compared to Surgical Microdebridement for Treating Achilles Tendinosis: A Prospective, Randomized, Controlled Multi-Center Study" Completed NCT00534781 Phase 4
11 Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection: A Double Blind Controlled Study Completed NCT02403856 Phase 4 Sodium Chloride 0.9%;Methylprednisolone acetate
12 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer: A Prospective, Randomized, Controlled Trial Completed NCT00950053 Phase 4
13 A Prospective Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 50mg etanercept;25mg etanercept;placebo
14 Evaluation of Clinical Efficacy and Comparison of Autologous Platelet Rich Plasma, Hyaluronic Acid, Corticosteroid and Saline Injections for Treating Lateral and Medial Humeral Epicondylopathy Recruiting NCT04521387 Phase 4 Platelet Rich Plasma;Corticosteroid Injection;Hyaluronic Acid Injection
15 Betamethason Versus Ketorolac Injection for the Treatment of DeQuervains Tenosynovitis Active, not recruiting NCT02604537 Phase 4 betamethasone;Ketorolac
16 Achilles Tendinopathy Treated With Heavy Slow Resistance Training Supplemented With Injection of Glucocorticosteroid or Local Anaesthetic. Active, not recruiting NCT02580630 Phase 4 Ultrasound guided injection with Glucocorticosteroid;Ultrasound guided injection with local anaestethic
17 Collagen and PRP in Partial Thickness Rotator Cuff Injuries: Friends or Only Indifferent Neighbors: Randomized Controlled Trial Active, not recruiting NCT04492748 Phase 4
18 Comparison of Leukocyte-rich Platelet Rich Plasma Injection to Percutaneous Tenotomy in the Treatment of Chronic Common Extensor Tendinopathy Not yet recruiting NCT04384809 Phase 4
19 Comparative Effectiveness of Particulate Versus Nonparticulate Corticosteroid Injections for the Treatment of Musculoskeletal Conditions Not yet recruiting NCT04278833 Phase 4 Triamcinolone or Betamethasone;Dexamethasone
20 Calcific Tendonitis Treatment: Barbotage vs. Barbotage With Cortisone Injection: A Randomized Controlled Double-Blind Study Not yet recruiting NCT04126278 Phase 4 Barbotage;Dexamethasone
21 Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial Suspended NCT04115644 Phase 4 Ketorolac;Marcaine (placebo);Kenalog
22 Ultrasound-Guided Platelet Rich Plasma Versus Whole Blood Injection for the Treatment of Gluteus Medius Tendinopathy: A Double-Blind Randomized Controlled Study Terminated NCT02978833 Phase 4
23 A Prospective Clinical Trial Comparing the Efficacy of Brisement to Physical Therapy for the Treatment of Achilles Tendinosis Withdrawn NCT03363789 Phase 4
24 A Single-blinded Randomized Controlled Trial Comparing Patients Who Receive a Corticosteroid Injection for Nontraumatic Degenerative Rotator Cuff Tears or Tendinopathy and Scheduled Use of a Dynamic Elastic Garment to Patients Who Receive a Corticosteroid Injection Alone. Withdrawn NCT03032432 Phase 4 Corticosteroid injection
25 "Clinical Evaluation of Placement of Radiofrequency-based Plasma Microdebridement in the Treatment Algorithm for Foot and Ankle Tendinosis and Plantar Fasciosis" Withdrawn NCT00420875 Phase 4
26 A Randomized Single Blinded Prospective Analysis for NSAID VS Corticosteroid Shoulder Injection in Diabetic Patients Withdrawn NCT03319784 Phase 4 Ketorolac;Triamcinolone Acetonide
27 Eccentric Training With Our Without Elbow Brace for Epicondylitis - a Randomized Clinical Trial Unknown status NCT01273688 Phase 3
28 Treatment of Subacromial Shoulder Pain Unknown status NCT01441830 Phase 3
29 Treatment for Achilles Tendinopathy Unknown status NCT00835939 Phase 2, Phase 3 25% Dextrose and 1% Lidocaine;Lidocaine
30 Multicenter, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety Aliviador Compared to Gelol in the Relief in Patients With Contusons, Sprains,Trauma and Muscle Injury. Unknown status NCT01097798 Phase 3 Aliviador;Gelol
31 Clinical Multicenter, Phase III, Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Ibuprofen 50mg/g Gel in the Treatment of Patients With Muscle Pain, Joint, or Pain Caused by Sprains, Contusions, Tendinitis, or Myofascial Compared to Profenid ® 25mg/g. Gel Unknown status NCT01373697 Phase 3 Ibuprofen;Profenid
32 Vibration Training in Epicondylitis - a Randomized Trial Unknown status NCT01269879 Phase 3
33 Clinical Multicenter Study, Randomized, Open, to Evaluate the Efficacy and Safety of Salonsip Compared to Sabiá Plaster Relief of the Signs and Symptoms in Patients With Contusions, Sprains, Injuries and Muscular Injuries With Less Than 24 Hours Early or Holders of Myalgia, Pain and Tendonitis in Regions Miofasciais Articulated. Unknown status NCT00970658 Phase 3 Salonsip plaster;Sabia plaster
34 Epidemiology of Incidents and Accidents in Sport. Influence of Moisture. Unknown status NCT02346786 Phase 3
35 A Randomized Clinical Trial Comparing the Effectiveness of Subacromial Decompression (Acromioplasty) Versus Subacromial Bursectomy (no Acromioplasty) in the Arthroscopic Treatment of Patients With Rotator Cuff Tendinosis Unknown status NCT00196573 Phase 3
36 Pilot Randomized Controlled Trial to Evaluate Safety and Efficacy of Percutaneous Needle Tenotomy With Platelet Rich Plasma (Leukocyte Depleted)in Epicondylitis Completed NCT01945528 Phase 3 US-guided tenotomy with PRP;US-guided tenotomy with lidocaine
37 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Diclofenac Sodium Patch for the Topical Treatment of Pain Due to Mild to Moderate Tendonitis or Bursitis Completed NCT00640939 Phase 2, Phase 3 diclofenac sodium;Matching Placebo
38 Role of Biological Therapy in Rotator Cuff Tendinopathy. Effectiveness of Plasma Rich in Growth Factors Regarding Functional Capacity and Pain Compared With the Conventional Treatment Using Steroids Completed NCT01915979 Phase 3 Celestone cronodose (Bethametasone)
39 The Value of Autologous Tenocyte Implantation in Patients With Chronic Achilles Tendinopathy: a Double-blind Randomised Clinical Trial Completed NCT01343836 Phase 2, Phase 3
40 Impact of Peripheral Pain Perception on Central Sensitization and Movement Strategies in Patients With Chronic Achilles Tendinopathy Completed NCT03316378 Phase 2, Phase 3 Ropivacaine injection
41 Analgesic Benefit of PECS Blocks for Biceps Tenodesis Shoulder Surgery Completed NCT02741713 Phase 3 Solution for Injection in Interscalene Block;Solution for Injection in Sham Block;Solution for Injection PECS Blocks
42 A Randomized, Multi-Center, Double-Blind, Placebo-Controlled Phase III Trial to Evaluate the Efficacy, Tolerability and Safety of MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder Completed NCT01161615 Phase 3 MRX-7EAT;Placebo
43 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Phase III Study of the Efficacy, Tolerability and Safety of Ketoprofen Topical Patch, 20% (KTP) in the Treatment of Pain Associated With Tendonitis or Bursitis of the Shoulder, Elbow or Knee Completed NCT00352625 Phase 3 Ketoprofen Topical Patch 20%
44 A Randomized, Multi-Center, Double-Blind, Placebo-Controlled Phase III Trial to Evaluate the Efficacy, Tolerability and Safety of MRX-7EAT Topical Patch in the Treatment of Pain Due to Recent Onset Supraspinatous and/or Subacromial Tendonitis/Bursitis and/or Subdeltoid Bursitis of Shoulder Completed NCT01506154 Phase 3 MRX-7EAT
45 Great Trochanteric Pain Syndrome: Parallel Group, Blind Randomised Clinical Trial to Assess the Efficacy and Safety of PRP Injection Versus Needle Tenotomy With Lidocaine Recruiting NCT04231357 Phase 3 platelet rich plasma
46 Does Subacromial Injection With Glutamate Receptor (NMDAR) Antagonist, Ketamine, Attenuate Pain in Rotator Cuff Tendinopathy? Recruiting NCT02967640 Phase 2, Phase 3 Ketalar;NaCl 9%
47 Evaluation of Regenerative Medicine Treatment Outcomes With Amniotic Fluid for Musculoskeletal Conditions Recruiting NCT03390920 Phase 2, Phase 3
48 Use of Extended Release Triamcinolone in the Treatment of Rotator Cuff Disease Recruiting NCT04094298 Phase 3 FX006 Injection
49 A Phase 3, Prospective, Double-Blinded, Randomized Controlled Trial Of The Micronized dHACM Injection As Compared To Saline Placebo Injection In The Treatment Of Achilles Tendonitis Active, not recruiting NCT03414255 Phase 3 Saline Injection
50 The Effect of Multiple Injection of Platlet-rich Plasma in Chronic Patellar Tendinopathy Not yet recruiting NCT03986372 Phase 2, Phase 3

Search NIH Clinical Center for Tendinopathy

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Tendinopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tendinopathy:
Autologous tenocyte implantation for damaged tendons
Embryonic/Adult Cultured Cells Related to Tendinopathy:
Tenocytes PMIDs: 23314880 24068695

Genetic Tests for Tendinopathy

Anatomical Context for Tendinopathy

MalaCards organs/tissues related to Tendinopathy:

Bone, Spinal Cord, Bone Marrow, Heart, Whole Blood, Pituitary, Hypothalamus

Publications for Tendinopathy

Articles related to Tendinopathy:

(show top 50) (show all 3903)
# Title Authors PMID Year
The plantaris muscle - Anatomical curiosity or a structure with important clinical value? - A comprehensive review of the current literature. 61
33561523 2021
Ultrasound-guided versus blind interventions in patellar tendon lesions: a cadaveric study. 61
33063137 2021
Evaluation of the Achilles Tendon Using B-Mode Ultrasound and Strain Elastography in Patients With Chronic Kidney Disease. 61
32856750 2021
Imaging of calcific tendinopathy around the shoulder: usual and unusual presentations and common pitfalls. 61
33151457 2021
Contralateral mechanical hyperalgesia and altered pain modulation in men who have unilateral insertional Achilles tendinopathy: A cross-sectional study. 61
33636582 2021
Ultrasound-guided percutaneous irrigation of calcific tendinopathy: redefining predictors of treatment outcome. 61
33040221 2021
Translation, cross-cultural adaptation and validation of the Brazilian Portuguese version of the Victorian Institute of Sports Assessment for Gluteal Tendinopathy patient reported-outcome measure (VISA-G.BR). 61
33581429 2021
The Use of Biologics for Hip Preservation. 61
33483876 2021
Ultrasound-Guided Percutaneous Tenotomy and Its Associated Pain Reduction and Functionality Outcomes in Nonelite Active Adults. 61
33727517 2021
Atypical femoral fracture as the cause of greater trochanteric pain syndrome - a case report. 61
33598061 2021
Hip Abductor and Peritrochanteric Space Conditions. 61
33673889 2021
The correlations between dimensions of the normal tendon and tendinopathy changed Achilles tendon in routine magnetic resonance imaging. 61
33731785 2021
Clinical Tests of Tibialis Posterior Tendinopathy: Are They Reliable and How Well Are They Reflected in Structural Changes on Imaging? 61
33779216 2021
Selected Clinical Features Fail to Predict Inflammatory Gene Expressions for TNF-α, TNFR1, NSMAF, Casp3 and IL-8 in Tendons of Patients with Rotator Cuff Tendinopathy. 61
33683459 2021
Upper limb position affects pain-free grip strength in individuals with lateral elbow tendinopathy. 61
33772973 2021
Endoscopic treatment of insertional Achilles tendinopathy: A cadaver feasibility study. 61
33746072 2021
"One Health" in tendinopathy research: Current concepts. 61
33713481 2021
Effect of Autologous Expanded Bone Marrow Mesenchymal Stem Cells or Leukocyte-Poor Platelet-Rich Plasma in Chronic Patellar Tendinopathy (With Gap >3 mm): Preliminary Outcomes After 6 Months of a Double-Blind, Randomized, Prospective Study. 61
33783227 2021
Effects of a "toes-off" modified heel raise on muscle coordination in non-dancers, dancers, and dancers with flexor hallucis longus tendinopathy. 61
33601167 2021
Exercise-Based Muscle Development Programmes and Their Effectiveness in the Functional Recovery of Rotator Cuff Tendinopathy: A Systematic Review. 61
33809604 2021
Acute fracture of extensive Achilles tendon calcific tendinopathy. 61
33691351 2021
Magnetic Resonance T2 * Is Increased in Patients With Early-Stage Achilles and Patellar Tendinopathy. 61
33719139 2021
Lower Limb Takeoff Mechanics During a Leap in Dancers With and Without Flexor Hallucis Longus Tendinopathy. 61
33647093 2021
Autoregulated and individualised resistance training versus predetermined and standardised resistance training in tendinopathy: A systematic review protocol. 61
33687141 2021
Serial Ultrasonographic and Real-Time Elastosonographic Assessment of the Ovine Common Calcaneal Tendon, after an Experimentally Induced Tendinopathy. 61
33806121 2021
Regarding ""Platelet-Rich Plasma in Patients With Partial-Thickness Rotator Cuff Tears or Tendinopathy Leads to Significantly Improved Short-Term Pain Relief and Function Compared with Corticosteroid Injection: A Double-Blind Randomized Controlled Trial". 61
33745937 2021
Author Reply to "Regarding "Platelet-Rich Plasma in Patients With Partial-Thickness Rotator Cuff Tears or Tendinopathy Leads to Significantly Improved Short-Term Pain Relief and Function Compared with Corticosteroid Injection: A Double-Blind Randomized Controlled Trial"". 61
33745940 2021
Clinical Outcomes, Structure, and Function Improve With Both Heavy and Moderate Loads in the Treatment of Patellar Tendinopathy: A Randomized Clinical Trial. 61
33616456 2021
Treatment of Achilles Tendinopathy in Recreational Runners with Peritendinous Hyaluronic Acid Injections: A Viscoelastometric, Functional, and Biochemical Pilot Study. 61
33807327 2021
Which treatment is most effective for patients with Achilles tendinopathy? A living systematic review with network meta-analysis of 29 randomised controlled trials. 61
32522732 2021
Are Plantarflexor Muscle Impairments Present Among Individuals with Achilles Tendinopathy and Do They Change with Exercise? A Systematic Review with Meta-analysis. 61
33689050 2021
Level of Evidence for the Treatment of Chronic Noninsertional Achilles Tendinopathy. 61
33749355 2021
Participant characteristics are poorly reported in exercise trials in tendinopathy: A systematic review. 61
33360409 2021
Immediate and long-term effects of mechanical loading on Achilles tendon volume: A systematic review and meta-analysis. 61
33556887 2021
[The Management of Mid-Portion Achilles Tendinopathy from a Physiotherapeutic Point of View: A Systematic Review]. 61
31639830 2021
Surgical treatment for insertional Achilles tendinopathy and retrocalcaneal bursitis: more than 1 year of follow-up. 61
33682490 2021
The analgesic effect of joint mobilization and manipulation in tendinopathy: a narrative review. 61
33769226 2021
Nonoperative treatment of insertional Achilles tendinopathy: a systematic review. 61
33785026 2021
Proximal hamstring tendinopathy; expert physiotherapists' perspectives on diagnosis, management and prevention. 61
33378733 2021
Curcuminoids and Boswellia serrata extracts combination decreases tendinopathy symptoms: findings from an open-label post-observational study. 61
33287570 2021
Letter to Editor: Comment on Reliability of Real-Time Sonoelastography in the Diagnosis of Supraspinatus Tendinopathy. 61
33661800 2021
Diagnosing Achilles tendinopathy is like delicious spaghetti carbonara: it is all about key ingredients, but not all chefs use the same recipe. 61
33055134 2021
Factors Associated With Clinical Improvement and the Disappearance of Calcifications After Ultrasound-Guided Percutaneous Lavage of Rotator Cuff Calcific Tendinopathy: A Post Hoc Analysis of a Randomized Controlled Trial. 61
33719606 2021
No Additive Clinical or Physiological Effects of Short-term Anti-inflammatory Treatment to Physical Rehabilitation in the Early Phase of Human Achilles Tendinopathy: A Randomized Controlled Trial. 61
33719579 2021
Endoscopic tenotomy for iliopsoas tendinopathy following total hip arthroplasty can relieve pain regardless acetabular cup overhang or anteversion. 61
33812032 2021
Motion-Control Shoes Reduce the Risk of Pronation-Related Pathologies in Recreational Runners: A Secondary Analysis of a Randomized Controlled Trial. 61
33306927 2021
Effect of Ankle Motion and Tensile Stress at the Achilles Tendon on the Contact Pressure Between the Achilles Tendon and the Calcaneus. 61
33766480 2021
Novel self-amplificatory loop between T cells and tenocytes as a driver of chronicity in tendon disease. 61
33692018 2021
Conservative management of acute lower limb tendinopathies: A systematic review. 61
32979021 2021
Treatment Efficacy Found in Animal Studies May Not Translate to Humans. 61
33775843 2021

Variations for Tendinopathy

Expression for Tendinopathy

Search GEO for disease gene expression data for Tendinopathy.

Pathways for Tendinopathy

Pathways related to Tendinopathy according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
11.95 MMP3 MMP1 CASP3
5 11.8 MMP1 CASP8 CASP3
Show member pathways
7 11.63 MMP3 CASP8 CASP3
Show member pathways
11.36 MMP3 MMP1
9 11.33 TIMP2 MMP3 MMP1
10 11.3 CASP8 CASP3
Show member pathways
11.25 CASP8 CASP3
Show member pathways
11.25 TIMP2 MMP8 MMP3 MMP1
13 11.22 MMP1 CASP3
14 11.17 CASP8 CASP3
15 11.1 MMP1 CASP8 CASP3
16 10.92 TIMP2 MMP3 MMP1

GO Terms for Tendinopathy

Cellular components related to Tendinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 TIMP2 MMP8 MMP3 ENPP1 COL5A1
2 extracellular region GO:0005576 9.63 TIMP2 MMP8 MMP3 MMP1 ENPP1 COL5A1
3 collagen-containing extracellular matrix GO:0062023 9.58 TIMP2 MMP8 COL5A1
4 specific granule lumen GO:0035580 9.37 TIMP2 MMP8
5 tertiary granule lumen GO:1904724 9.32 TIMP2 MMP8
6 extracellular matrix GO:0031012 9.02 TIMP2 MMP8 MMP3 MMP1 COL5A1
7 death-inducing signaling complex GO:0031264 8.96 CASP8 CASP3

Biological processes related to Tendinopathy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 MMP3 MMP1 CASP3
2 extracellular matrix organization GO:0030198 9.56 MMP8 MMP3 MMP1 COL5A1
3 proteolysis GO:0006508 9.55 MMP8 MMP3 MMP1 CASP8 CASP3
4 positive regulation of protein complex assembly GO:0031334 9.51 MMP3 MMP1
5 response to tumor necrosis factor GO:0034612 9.48 CASP8 CASP3
6 response to antibiotic GO:0046677 9.46 CASP8 CASP3
7 execution phase of apoptosis GO:0097194 9.43 CASP8 CASP3
8 regulation of neuroinflammatory response GO:0150077 9.4 MMP8 MMP3
9 cellular response to UV-A GO:0071492 9.37 MMP3 MMP1
10 response to cobalt ion GO:0032025 9.32 CASP8 CASP3
11 collagen catabolic process GO:0030574 9.13 MMP8 MMP3 MMP1
12 extracellular matrix disassembly GO:0022617 8.92 TIMP2 MMP8 MMP3 MMP1

Molecular functions related to Tendinopathy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.67 MMP8 MMP3 MMP1
2 metallopeptidase activity GO:0008237 9.65 MMP8 MMP3 MMP1
3 hydrolase activity GO:0016787 9.63 MMP8 MMP3 MMP1 ENPP1 CASP8 CASP3
4 metalloendopeptidase activity GO:0004222 9.5 MMP8 MMP3 MMP1
5 death receptor binding GO:0005123 9.46 CASP8 CASP3
6 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.43 CASP8 CASP3
7 endopeptidase activity GO:0004175 9.43 MMP8 MMP3 MMP1
8 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.4 CASP8 CASP3
9 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.37 CASP8 CASP3
10 zinc ion binding GO:0008270 9.35 TIMP2 MMP8 MMP3 MMP1 ENPP1
11 peptidase activity GO:0008233 9.02 MMP8 MMP3 MMP1 CASP8 CASP3

Sources for Tendinopathy

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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