Aliases & Classifications for Tendinopathy

MalaCards integrated aliases for Tendinopathy:

Name: Tendinopathy 40 37 17 71

External Ids:

UMLS 71 C1568272

Summaries for Tendinopathy

MalaCards based summary : Tendinopathy is related to tendinosis and synovitis, and has symptoms including muscle weakness, myalgia and muscle cramp. An important gene associated with Tendinopathy is ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1), and among its related pathways/superpathways are Integrin Pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). The drugs Polidocanol and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spinal cord, and related phenotype is homeostasis/metabolism.

Wikipedia : 74 Tendinopathy, also known as tendinitis or tendonitis, is a type of tendon disorder that results in pain,... more...

Related Diseases for Tendinopathy

Diseases related to Tendinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 tendinosis 32.7 MMP3 MMP1
2 synovitis 29.9 MMP8 MMP3 MMP1
3 tendinitis 12.3
4 tenosynovitis 11.6
5 cole disease 11.4
6 de quervain disease 11.3
7 rapidly involuting congenital hemangioma 10.9
8 epicondylitis 10.8
9 frozen shoulder 10.5
10 bursitis 10.5
11 fasciitis 10.5
12 plantar fasciitis 10.5
13 chronic pain 10.4
14 calcific tendinitis 10.4
15 shoulder impingement syndrome 10.4
16 enthesopathy 10.2
17 exostosis 10.2
18 periarthritis 10.2
19 osteoarthritis 10.2
20 diabetes mellitus 10.2
21 superior limbic keratoconjunctivitis 10.2 MMP3 MMP1
22 gout 10.2
23 47,xyy 10.2
24 spastic entropion 10.1 MMP3 MMP1
25 conjunctivochalasis 10.1 MMP3 MMP1
26 periodontitis, chronic 10.1 MMP8 MMP1
27 corneal ulcer 10.1 MMP3 MMP1
28 androgen insensitivity, partial 10.1
29 body mass index quantitative trait locus 1 10.1
30 patellar tendinitis 10.1
31 arthropathy 10.1
32 epidermolysis bullosa dystrophica 10.1 MMP3 MMP1
33 caspase 8 deficiency 10.1 COL5A1 CASP8
34 corneal edema 10.1 MMP3 MMP1
35 periodontitis, aggressive, 1 10.1 MMP8 MMP1
36 bone deterioration disease 10.1 MMP3 MMP1
37 viral meningitis 10.1 MMP3 MMP1
38 dentin caries 10.1 MMP8 MMP3
39 spinal stenosis 10.0 MMP3 MMP1
40 chronic ulcer of skin 10.0 MMP8 MMP1
41 septic arthritis 10.0 MMP3 MMP1
42 spondyloepimetaphyseal dysplasia, missouri type 10.0 MMP8 MMP3
43 gingival disease 10.0 MMP8 MMP1
44 carpal tunnel syndrome 10.0
45 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
46 body mass index quantitative trait locus 11 10.0
47 arts syndrome 10.0
48 body mass index quantitative trait locus 9 10.0
49 body mass index quantitative trait locus 8 10.0
50 body mass index quantitative trait locus 4 10.0

Graphical network of the top 20 diseases related to Tendinopathy:



Diseases related to Tendinopathy

Symptoms & Phenotypes for Tendinopathy

UMLS symptoms related to Tendinopathy:


muscle weakness, myalgia, muscle cramp, muscle rigidity, muscle spasticity

MGI Mouse Phenotypes related to Tendinopathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 CASP3 CASP8 ENPP1 MMP1 MMP3 MMP8

Drugs & Therapeutics for Tendinopathy

Drugs for Tendinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 167)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polidocanol Approved Phase 4 9002-92-0
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
3
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
4
Etanercept Approved, Investigational Phase 4 185243-69-0
5
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
6 Sclerosing Solutions Phase 4
7 Cyclooxygenase 2 Inhibitors Phase 4
8 Adjuvants, Immunologic Phase 4
9 Viscosupplements Phase 4
10
Zinc Approved, Investigational Phase 3 7440-66-6 32051
11
Ibuprofen Approved Phase 3 15687-27-1 3672
12
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
13
Copper Approved, Investigational Phase 3 7440-50-8 27099
14
Etodolac Approved, Investigational, Vet_approved Phase 3 41340-25-4 3308
15
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
16
Ofloxacin Approved Phase 3 82419-36-1 4583
17
Clonidine Approved Phase 3 4205-90-7 2803
18
Ketamine Approved, Vet_approved Phase 2, Phase 3 6740-88-1 3821
19
Glycolic acid Approved, Investigational Phase 3 79-14-1 757
20
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
21
Ketoprofen Approved, Vet_approved Phase 3 22071-15-4 3825
22
Manganese Approved, Nutraceutical Phase 3 7439-96-5 27854
23
Glutamic acid Approved, Nutraceutical Phase 2, Phase 3 56-86-0 33032
24
Cortisone Experimental Phase 3 53-06-5 222786
25 Anti-Bacterial Agents Phase 3
26 Anti-Infective Agents Phase 3
27 Cytochrome P-450 Enzyme Inhibitors Phase 3
28 Renal Agents Phase 3
29 Topoisomerase Inhibitors Phase 3
30 Anti-Infective Agents, Urinary Phase 3
31 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
32 Adrenergic alpha-2 Receptor Agonists Phase 3
33 Antihypertensive Agents Phase 3
34 Sympatholytics Phase 3
35 Anesthetics, General Phase 2, Phase 3
36 Anesthetics, Dissociative Phase 2, Phase 3
37 Anesthetics, Intravenous Phase 2, Phase 3
38 Excitatory Amino Acids Phase 2, Phase 3
39 Excitatory Amino Acid Antagonists Phase 2, Phase 3
40 Carboxymethylcellulose Sodium Phase 3
41 Betamethasone benzoate Phase 3
42 Betamethasone Valerate Phase 3 2152-44-5
43 Betamethasone sodium phosphate Phase 3
44 Betamethasone-17,21-dipropionate Phase 3
45 Betamethasone dipropionate, betamethasone sodium phosphate drug combination Phase 3
46
Nitric Oxide Approved Phase 2 10102-43-9 145068
47
Acetaminophen Approved Phase 2 103-90-2 1983
48
Tetracaine Approved, Vet_approved Phase 2 94-24-6 5411
49
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
50 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show top 50) (show all 291)
# Name Status NCT ID Phase Drugs
1 Insertional Achilles Tendinopathy: A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon Unknown status NCT01341509 Phase 4
2 Celestone Versus Ketorolac Injection for the Treatment of DeQuervains Tenosyovitis Unknown status NCT02604537 Phase 4 Celestone;Ketorolac
3 Placebo Controlled Trial, Testing the Efficacy of Polidocanol Injections as a Treatment of Chronic Achilles Tendinopathy. Completed NCT00377910 Phase 4 Aethoxysclerol
4 "NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control, Leg Stiffness and Functional Recovery in Athletes" Completed NCT00792376 Phase 4 etoricoxib;diclofenac
5 Shockwave Therapy of Chronic Achilles Tendinopathy. A Double-blind, Randomized Clinical Trial of Efficacy Completed NCT00958620 Phase 4
6 The Value of a High-Volume Image-Guided Injection in Chronic Midportion Achilles Tendinopathy: a Double-blind, Randomized, Placebo-controlled Clinical Trial Completed NCT02996409 Phase 4 HVIGI;LVIGI
7 The Value of Platelet-Rich Plasma in Chronic Midportion Achilles Tendinopathy: a Double-blind Randomized Clinical Trial Completed NCT00761423 Phase 4
8 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to a Single Intrabursal Injection of Corticosteroids in Patients With Shoulder Calcific Tendinopathy Completed NCT01652495 Phase 4 methylprednisolone acetate;Triamcinolone Acetonide
9 Radiofrequency-based Plasma Microdebridement Compared to Surgical Microdebridement for Treating Achilles Tendinosis: A Prospective, Randomized, Controlled Multi-Center Study" Completed NCT00534781 Phase 4
10 Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection: A Double Blind Controlled Study Completed NCT02403856 Phase 4 Sodium Chloride 0.9%;Methylprednisolone acetate
11 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer: A Prospective, Randomized, Controlled Trial Completed NCT00950053 Phase 4
12 A Prospective Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 50mg etanercept;25mg etanercept;placebo
13 A Single-blinded Randomized Controlled Trial Comparing Patients Who Receive a Corticosteroid Injection for Nontraumatic Degenerative Rotator Cuff Tears or Tendinopathy and Scheduled Use of a Dynamic Elastic Garment to Patients Who Receive a Corticosteroid Injection Alone. Recruiting NCT03032432 Phase 4 Corticosteroid injection
14 Achilles Tendinopathy Treated With Heavy Slow Resistance Training Supplemented With Injection of Glucocorticosteroid or Local Anaesthetic. Recruiting NCT02580630 Phase 4 Ultrasound guided injection with Glucocorticosteroid;Ultrasound guided injection with local anaestethic
15 Functional Improvement and Ultrasound Tissue Characterisation of the Achilles Tendon Following Sodium Hyaluronate Injection for Plantaris Friction Syndrome Recruiting NCT03077009 Phase 4 Hyaluronic Acid
16 Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial Recruiting NCT04115644 Phase 4 Ketorolac;Marcaine (placebo);Kenalog
17 Calcific Tendonitis Treatment: Barbotage vs. Barbotage With Cortisone Injection: A Randomized Controlled Double-Blind Study Not yet recruiting NCT04126278 Phase 4 Barbotage;Dexamethasone
18 Efficacy Evaluation of Surgical Treatment Using Bioinductive Implant for Tennis Elbow (Lateral Epicondylitis) Not yet recruiting NCT03718637 Phase 4
19 Ultrasound-Guided Platelet Rich Plasma Versus Whole Blood Injection for the Treatment of Gluteus Medius Tendinopathy: A Double-Blind Randomized Controlled Study Terminated NCT02978833 Phase 4
20 A Prospective Clinical Trial Comparing the Efficacy of Brisement to Physical Therapy for the Treatment of Achilles Tendinosis Withdrawn NCT03363789 Phase 4
21 A Randomized Single Blinded Prospective Analysis for NSAID VS Corticosteroid Shoulder Injection in Diabetic Patients Withdrawn NCT03319784 Phase 4 Ketorolac;Triamcinolone Acetonide
22 "Clinical Evaluation of Placement of Radiofrequency-based Plasma Microdebridement in the Treatment Algorithm for Foot and Ankle Tendinosis and Plantar Fasciosis" Withdrawn NCT00420875 Phase 4
23 Treatment for Achilles Tendinopathy Unknown status NCT00835939 Phase 2, Phase 3 25% Dextrose and 1% Lidocaine;Lidocaine
24 Eccentric Training With Our Without Elbow Brace for Epicondylitis - a Randomized Clinical Trial Unknown status NCT01273688 Phase 3
25 Vibration Training in Epicondylitis - a Randomized Trial Unknown status NCT01269879 Phase 3
26 Treatment of Subacromial Shoulder Pain Unknown status NCT01441830 Phase 3
27 Multicenter, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety Aliviador Compared to Gelol in the Relief in Patients With Contusons, Sprains,Trauma and Muscle Injury. Unknown status NCT01097798 Phase 3 Aliviador;Gelol
28 Clinical Multicenter, Phase III, Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Ibuprofen 50mg/g Gel in the Treatment of Patients With Muscle Pain, Joint, or Pain Caused by Sprains, Contusions, Tendinitis, or Myofascial Compared to Profenid ® 25mg/g. Gel Unknown status NCT01373697 Phase 3 Ibuprofen;Profenid
29 Clinical Multicenter Study, Randomized, Open, to Evaluate the Efficacy and Safety of Salonsip Compared to Sabiá Plaster Relief of the Signs and Symptoms in Patients With Contusions, Sprains, Injuries and Muscular Injuries With Less Than 24 Hours Early or Holders of Myalgia, Pain and Tendonitis in Regions Miofasciais Articulated. Unknown status NCT00970658 Phase 3 Salonsip plaster;Sabia plaster
30 A Randomized Clinical Trial Comparing the Effectiveness of Subacromial Decompression (Acromioplasty) Versus Subacromial Bursectomy (no Acromioplasty) in the Arthroscopic Treatment of Patients With Rotator Cuff Tendinosis Unknown status NCT00196573 Phase 3
31 Epidemiology of Incidents and Accidents in Sport. Influence of Moisture. Unknown status NCT02346786 Phase 3
32 The Value of Autologous Tenocyte Implantation in Patients With Chronic Achilles Tendinopathy: a Double-blind Randomised Clinical Trial Completed NCT01343836 Phase 2, Phase 3
33 Impact of Peripheral Pain Perception on Central Sensitization and Movement Strategies in Patients With Chronic Achilles Tendinopathy Completed NCT03316378 Phase 2, Phase 3 Ropivacaine injection
34 Role of Biological Therapy in Rotator Cuff Tendinopathy. Effectiveness of Plasma Rich in Growth Factors Regarding Functional Capacity and Pain Compared With the Conventional Treatment Using Steroids Completed NCT01915979 Phase 3 Celestone cronodose (Bethametasone)
35 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Diclofenac Sodium Patch for the Topical Treatment of Pain Due to Mild to Moderate Tendonitis or Bursitis Completed NCT00640939 Phase 2, Phase 3 diclofenac sodium;Matching Placebo
36 A Randomized, Multi-Center, Double-Blind, Placebo-Controlled Phase III Trial to Evaluate the Efficacy, Tolerability and Safety of MRX-7EAT Topical Patch in the Treatment of Pain Due to Recent Onset Supraspinatous and/or Subacromial Tendonitis/Bursitis and/or Subdeltoid Bursitis of Shoulder Completed NCT01506154 Phase 3 MRX-7EAT
37 A Randomized, Multi-Center, Double-Blind, Placebo-Controlled Phase III Trial to Evaluate the Efficacy, Tolerability and Safety of MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder Completed NCT01161615 Phase 3 MRX-7EAT;Placebo
38 Pilot Randomized Controlled Trial to Evaluate Safety and Efficacy of Percutaneous Needle Tenotomy With Platelet Rich Plasma (Leukocyte Depleted)in Epicondylitis Completed NCT01945528 Phase 3 US-guided tenotomy with PRP;US-guided tenotomy with lidocaine
39 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Phase III Study of the Efficacy, Tolerability and Safety of Ketoprofen Topical Patch, 20% (KTP) in the Treatment of Pain Associated With Tendonitis or Bursitis of the Shoulder, Elbow or Knee Completed NCT00352625 Phase 3 Ketoprofen Topical Patch 20%
40 A Randomized Trial of Levofloxacin to Prevent Bacteremia in Children Being Treated for Acute Leukemia (AL) or Undergoing Hematopoietic Stem Cell Transplantation (HSCT) Completed NCT01371656 Phase 3 levofloxacin
41 Analgesic Benefit of PECS Blocks for Biceps Tenodesis Shoulder Surgery Completed NCT02741713 Phase 3 Solution for Injection in Interscalene Block;Solution for Injection in Sham Block;Solution for Injection PECS Blocks
42 Does Subacromial Injection With Glutamate Receptor (NMDAR) Antagonist, Ketamine, Attenuate Pain in Rotator Cuff Tendinopathy? Recruiting NCT02967640 Phase 2, Phase 3 Ketalar;NaCl 9%
43 A Phase 3, Prospective, Double-Blinded, Randomized Controlled Trial Of The Micronized dHACM Injection As Compared To Saline Placebo Injection In The Treatment Of Achilles Tendonitis Recruiting NCT03414255 Phase 3 Saline Injection
44 Use of Extended Release Triamcinolone in the Treatment of Rotator Cuff Disease Recruiting NCT04094298 Phase 3 FX006 Injection
45 Evaluation of Regenerative Medicine Treatment Outcomes With Amniotic Fluid for Musculoskeletal Conditions Recruiting NCT03390920 Phase 2, Phase 3
46 The Effect of Multiple Injection of Platlet-rich Plasma in Chronic Patellar Tendinopathy Not yet recruiting NCT03986372 Phase 2, Phase 3
47 A Randomised Double Blind Controlled Trial of Injection of Local Anaesthetic and Corticosteroid Under Ultrasound Control in the Greater Trochanteric Pain Syndrome. Terminated NCT01807962 Phase 3 rapidocain and bethametsaone;sterile saline
48 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Phase III Study of the Efficacy, Tolerability and Safety of Ketoprofen Topical Patch, 20% (KTP) in the Treatment of Pain Associated With Tendonitis or Bursitis of the Shoulder, Elbow or Knee Terminated NCT00426985 Phase 3 Ketoprofen Topical Patch 20%
49 Medial-Wedge Insole is Highly Effective in the Treatment of Valgus Knee Osteoarthritis Terminated NCT00467337 Phase 3
50 Plasma Glucose Levels With Dexamethasone as Adjuvant to Interscalene Block Withdrawn NCT01538459 Phase 3 Dexamethasone;Bupivacaine

Search NIH Clinical Center for Tendinopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Tendinopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tendinopathy:
Autologous tenocyte implantation for damaged tendons
Embryonic/Adult Cultured Cells Related to Tendinopathy:
Tenocytes PMIDs: 23314880 24068695

Genetic Tests for Tendinopathy

Anatomical Context for Tendinopathy

MalaCards organs/tissues related to Tendinopathy:

40
Bone, Testes, Spinal Cord, Bone Marrow, Heart, Whole Blood, Endothelial

Publications for Tendinopathy

Articles related to Tendinopathy:

(show top 50) (show all 3427)
# Title Authors PMID Year
1
Efficacy of ultrasound-guided percutaneous treatment of the rotator cuff calcific tendinopathy with double needle technique. 61
32025148 2020
2
Adipose-derived stem cells improve tendon repair and prevent ectopic ossification in tendinopathy by inhibiting inflammation and inducing neovascularization in the early stage of tendon healing. 61
31989000 2020
3
Isometric exercise and pain in patellar tendinopathy: A randomized crossover trial. 61
31735531 2020
4
Characterisation of Achilles tendon pain in recreational runners using multidimensional pain scales. 61
31718904 2020
5
Efficacy Comparison of Hyaluronic Acid and Corticosteroid Injection in Treatment of Trigger Digits: A Randomized Controlled Trial. 61
32000598 2020
6
In vivo evaluation of human patellar tendon microstructure and microcirculation with diffusion MRI. 61
31407413 2020
7
A systematic review of inflammatory cells and markers in human tendinopathy. 61
32028937 2020
8
Rethinking Patellar Tendinopathy and Partial Patellar Tendon Tears: A Novel Classification System. 61
31913662 2020
9
Surgical treatment for long head of the biceps tendinopathy: a network meta-analysis. 61
32037231 2020
10
Non-surgical treatment of patellar tendinopathy: A systematic review of randomized controlled trials. 61
31606317 2020
11
Unsupervised Isometric Exercise versus Wait-and-See for Lateral Elbow Tendinopathy. 61
31425384 2020
12
The Association Between Symptoms of Depression and Office Visits in Patients With Nontraumatic Upper-Extremity Illness. 61
31300225 2020
13
Platelet-Rich Plasma for Patellar Tendinopathy: Response. 61
32003631 2020
14
Platelet-Rich Plasma for Patellar Tendinopathy: Letter to the Editor. 61
32003638 2020
15
H. pylori, Heart Failure, Acupuncture, Injections for Tendinopathy, Hirsutism. 61
32003954 2020
16
Revolving doors of tendinopathy: definition, pathogenesis and treatment. 61
31757873 2020
17
Evaluation of the Knees of Asymptomatic Kangoo Jumpers with MR Imaging. 61
30700660 2020
18
Tolerance and effect of sodium thiosulfate in calcific tendinitis of the rotator cuff. 61
31673978 2020
19
7-T clinical MRI of the shoulder in patients with suspected lesions of the rotator cuff. 61
32030499 2020
20
A Case of Medial Tibial Crest Friction Syndrome: A Rare Cause of Medial Knee Pain. 61
32032157 2020
21
Avocado/Soybean Unsaponifiables, Glucosamine and Chondroitin Sulfate Combination Inhibits Proinflammatory COX-2 Expression and Prostaglandin E2 Production in Tendon-Derived Cells. 61
31486703 2020
22
Rotator cuff integrity and shoulder function after intra-medullary humerus nailing. 61
31882328 2020
23
Functional COL1A1 variants are associated with the risk of acute musculoskeletal soft tissue injuries. 61
32017203 2020
24
Iliopsoas Release: A Systematic Review of Clinical Efficacy and Associated Complications. 61
32032164 2020
25
Chronic Lower Leg Pain in Athletes: Overview of Presentation and Management. 61
32015745 2020
26
No superiority of dextrose injections over placebo injections for Osgood-Schlatter disease: a prospective randomized double-blind study. 61
31713082 2020
27
Neovascularisation in tendinopathy: from eradication to stabilisation? 61
31594793 2020
28
Landing Biomechanics, But Not Physical Activity, Differ in Young Male Athletes With and Without Patellar Tendinopathy. 61
31905096 2020
29
Dorsal wedge calcaneal osteotomy as surgical treatment for insertional Achilles tendinopathy. 61
31672479 2020
30
Dry Needling as a Treatment Modality for Tendinopathy: a Narrative Review. 61
31942676 2020
31
Endoscopic Flexor Hallucis Longus Transfer for Achilles Noninsertional Tendinopathy: Description of Surgical Technique and Functional Outcomes. 61
31916453 2020
32
Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling. 61
31914656 2020
33
Effectiveness of extensor carpi ulnaris tendon lengthening in treating four patients with tendinopathy. 61
31533512 2020
34
Calcific tendinopathy of the rotator cuff: a review of operative versus nonoperative management. 61
31893972 2020
35
Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy? 61
31967969 2020
36
Effectiveness of Extracorporeal Shockwave Therapy in the Treatment of Chronic Insertional Achilles Tendinopathy. 61
31924120 2020
37
The current role of Astym therapy in the treatment of musculoskeletal disorders. 61
31461382 2020
38
Pioglitazone attenuates advanced glycation end products-induced apoptosis and calcification by modulating autophagy in tendon-derived stem cells. 61
31957239 2020
39
Orthobiologics for the Hip Region: A Narrative Review. 61
31953917 2020
40
Is There Any Association Between Foot Posture and Lower Limb-Related Injuries in Professional Male Basketball Players? A Cross-Sectional Study. 61
31855912 2020
41
The Behavior of Tendon Progenitor Cells from Tendinopathic Tendons: Implications for Treatment. 61
31111771 2020
42
Effects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing. 61
31166037 2020
43
MicroRNA Profiling Reveals Distinct Signatures in Degenerative Rotator Cuff Pathologies. 61
31520478 2020
44
A single-pulsed electromagnetic field enhances collagen synthesis in tendon cells. 61
31954614 2020
45
The association of working alliance, outcome expectation, adherence and self-efficacy with clinical outcomes for Achilles tendinopathy: A feasibility cohort study (the MAP study). 61
31997555 2020
46
Therapeutic Response of Extracorporeal Shock Wave Therapy for Insertional Achilles Tendinopathy Between Sports-Active and Nonsports-Active Patients With 5-Year Follow-up. 61
32030348 2020
47
Qualitative and quantitative analysis of glenoid bone stock and glenoid version: inter-reader analysis and correlation with rotator cuff tendinopathy and atrophy in patients with shoulder osteoarthritis. 61
31955231 2020
48
Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy. 61
31329308 2020
49
A high glucose level stimulate inflammation and weaken pro-resolving response in tendon cells - A possible factor contributing to tendinopathy in diabetic patients. 61
31871896 2020
50
How strong is the evidence that conservative treatment reduces pain and improves function in individuals with patellar tendinopathy? A systematic review of randomised controlled trials including GRADE recommendations. 61
31171514 2020

Variations for Tendinopathy

Expression for Tendinopathy

Search GEO for disease gene expression data for Tendinopathy.

Pathways for Tendinopathy

Pathways related to Tendinopathy according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 VCAN MMP8 MMP3 MMP1 COL5A1 CASP3
2
Show member pathways
11.89 MMP3 MMP1 CASP3
3
Show member pathways
11.89 MMP3 MMP1 CASP8 CASP3
4 11.84 MMP1 CASP8 CASP3
5
Show member pathways
11.75 VCAN MMP8 MMP3 MMP1 COL5A1 CASP3
6 11.66 MMP3 CASP8 CASP3
7
Show member pathways
11.58 MMP8 MMP3 MMP1
8
Show member pathways
11.36 MMP3 MMP1
9 11.3 CASP8 CASP3
10 11.28 VCAN MMP3 MMP1
11 11.24 MMP1 CASP3
12
Show member pathways
11.21 CASP8 CASP3
13 11.14 CASP8 CASP3
14 11.1 CASP8 CASP3
15 10.99 MMP1 CASP8 CASP3
16 10.72 VCAN MMP3 MMP1

GO Terms for Tendinopathy

Cellular components related to Tendinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 VCAN MMP8 MMP3 ENPP1 COL5A1
2 extracellular region GO:0005576 9.63 VCAN MMP8 MMP3 MMP1 ENPP1 COL5A1
3 collagen-containing extracellular matrix GO:0062023 9.5 VCAN MMP8 COL5A1
4 extracellular matrix GO:0031012 9.02 VCAN MMP8 MMP3 MMP1 COL5A1
5 death-inducing signaling complex GO:0031264 8.96 CASP8 CASP3

Biological processes related to Tendinopathy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 MMP3 MMP1 CASP3
2 proteolysis GO:0006508 9.55 MMP8 MMP3 MMP1 CASP8 CASP3
3 positive regulation of protein complex assembly GO:0031334 9.48 MMP3 MMP1
4 response to tumor necrosis factor GO:0034612 9.46 CASP8 CASP3
5 response to antibiotic GO:0046677 9.43 CASP8 CASP3
6 extracellular matrix disassembly GO:0022617 9.43 MMP8 MMP3 MMP1
7 execution phase of apoptosis GO:0097194 9.4 CASP8 CASP3
8 regulation of neuroinflammatory response GO:0150077 9.37 MMP8 MMP3
9 response to cobalt ion GO:0032025 9.32 CASP8 CASP3
10 collagen catabolic process GO:0030574 9.13 MMP8 MMP3 MMP1
11 extracellular matrix organization GO:0030198 9.02 VCAN MMP8 MMP3 MMP1 COL5A1

Molecular functions related to Tendinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.78 MMP8 MMP3 MMP1 ENPP1
2 metallopeptidase activity GO:0008237 9.63 MMP8 MMP3 MMP1
3 serine-type endopeptidase activity GO:0004252 9.61 MMP8 MMP3 MMP1
4 metalloendopeptidase activity GO:0004222 9.43 MMP8 MMP3 MMP1
5 hydrolase activity GO:0016787 9.43 MMP8 MMP3 MMP1 ENPP1 CASP8 CASP3
6 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.4 CASP8 CASP3
7 death receptor binding GO:0005123 9.37 CASP8 CASP3
8 endopeptidase activity GO:0004175 9.33 MMP8 MMP3 MMP1
9 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.32 CASP8 CASP3
10 peptidase activity GO:0008233 9.02 MMP8 MMP3 MMP1 CASP8 CASP3

Sources for Tendinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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