Aliases & Classifications for Tendinopathy

MalaCards integrated aliases for Tendinopathy:

Name: Tendinopathy 40 37 17 71

External Ids:

UMLS 71 C1568272

Summaries for Tendinopathy

MalaCards based summary : Tendinopathy is related to tendinosis and synovitis, and has symptoms including muscle weakness, myalgia and muscle cramp. An important gene associated with Tendinopathy is COL5A1 (Collagen Type V Alpha 1 Chain), and among its related pathways/superpathways are Integrin Pathway and IL-17 Family Signaling Pathways. The drugs Polidocanol and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and bone marrow, and related phenotypes are cardiovascular system and immune system

Wikipedia : 74 Tendinopathy, also known as tendinitis or tendonitis, is a type of tendon disorder that results in pain,... more...

Related Diseases for Tendinopathy

Diseases related to Tendinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 tendinosis 32.0 MMP3 MMP1
2 synovitis 29.5 TIMP2 MMP8 MMP3 MMP1
3 clubfoot 29.4 COL5A1 CASP8 CASP3
4 tendinitis 11.7
5 cole disease 11.1
6 tenosynovitis 11.0
7 de quervain disease 10.9
8 rapidly involuting congenital hemangioma 10.8
9 epicondylitis 10.6
10 frozen shoulder 10.5
11 bursitis 10.5
12 fasciitis 10.3
13 chronic pain 10.3
14 plantar fasciitis 10.3
15 shoulder impingement syndrome 10.3
16 calcific tendinitis 10.2
17 enthesopathy 10.2
18 superior limbic keratoconjunctivitis 10.2 MMP3 MMP1
19 coronary artery aneurysm 10.2 MMP3 MMP1
20 spastic entropion 10.2 MMP3 MMP1
21 exostosis 10.1
22 osteoarthritis 10.1
23 corneal edema 10.1 MMP3 MMP1
24 epidermolysis bullosa dystrophica 10.1 MMP3 MMP1
25 plica syndrome 10.1
26 gout 10.1
27 periodontitis, chronic 10.1 MMP8 MMP1
28 caspase 8 deficiency 10.1 COL5A1 CASP8
29 periodontitis, aggressive, 1 10.1 MMP8 MMP1
30 septic arthritis 10.0 MMP3 MMP1
31 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
32 periarthritis 10.0
33 arthropathy 10.0
34 47,xyy 10.0
35 gingival disease 10.0 MMP8 MMP1
36 lymph node disease 10.0 MMP3 MMP1
37 lipodermatosclerosis 10.0 TIMP2 MMP1
38 exfoliation syndrome 10.0 MMP3 MMP1
39 body mass index quantitative trait locus 11 10.0
40 body mass index quantitative trait locus 9 10.0
41 body mass index quantitative trait locus 8 10.0
42 body mass index quantitative trait locus 4 10.0
43 body mass index quantitative trait locus 10 10.0
44 body mass index quantitative trait locus 7 10.0
45 body mass index quantitative trait locus 12 10.0
46 body mass index quantitative trait locus 14 10.0
47 body mass index quantitative trait locus 18 10.0
48 body mass index quantitative trait locus 19 10.0
49 pain agnosia 10.0
50 patellar tendinitis 10.0

Graphical network of the top 20 diseases related to Tendinopathy:



Diseases related to Tendinopathy

Symptoms & Phenotypes for Tendinopathy

UMLS symptoms related to Tendinopathy:


muscle weakness, myalgia, muscle cramp, muscle rigidity, muscle spasticity

MGI Mouse Phenotypes related to Tendinopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 CASP3 CASP8 COL5A1 ENPP1 MMP8 TIMP2
2 immune system MP:0005387 9.17 CASP3 CASP8 ENPP1 MMP1 MMP3 MMP8

Drugs & Therapeutics for Tendinopathy

Drugs for Tendinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 148)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polidocanol Approved Phase 4 9002-92-0
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
3
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
4
Etanercept Approved, Investigational Phase 4 185243-69-0
5
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
6
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
7
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
8
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
11
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
12
Cortisone Experimental Phase 4 53-06-5 222786
13 Protective Agents Phase 4
14 Sclerosing Solutions Phase 4
15 Cyclooxygenase 2 Inhibitors Phase 4
16 Viscosupplements Phase 4
17 Adjuvants, Immunologic Phase 4
18 Respiratory System Agents Phase 4
19 Gastrointestinal Agents Phase 4
20 Antineoplastic Agents, Hormonal Phase 4
21 Antiemetics Phase 4
22 Anti-Asthmatic Agents Phase 4
23
Ibuprofen Approved Phase 3 15687-27-1 3672
24
Copper Approved, Investigational Phase 3 7440-50-8 27099
25
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
26
Zinc Approved, Investigational Phase 3 7440-66-6 32051
27
Ropivacaine Approved Phase 2, Phase 3 84057-95-4 71273 175805
28
Clonidine Approved Phase 3 4205-90-7 2803
29
Etodolac Approved, Investigational, Vet_approved Phase 3 41340-25-4 3308
30
Ketamine Approved, Vet_approved Phase 2, Phase 3 6740-88-1 3821
31
Glycolic acid Approved, Investigational Phase 3 79-14-1 757
32
Ketoprofen Approved, Vet_approved Phase 3 22071-15-4 3825
33
Manganese Approved, Nutraceutical Phase 3 7439-96-5 27854
34
Glutamic acid Approved, Nutraceutical Phase 2, Phase 3 56-86-0 33032
35 Calcium, Dietary Phase 3
36 Copper Supplement Phase 3
37 Adrenergic alpha-Agonists Phase 3
38 Adrenergic Agents Phase 3
39 Sympathomimetics Phase 3
40 Adrenergic Agonists Phase 3
41 Vasoconstrictor Agents Phase 3
42 Adrenergic beta-Agonists Phase 3
43 Sympatholytics Phase 3
44 Antihypertensive Agents Phase 3
45 Mydriatics Phase 3
46 Bronchodilator Agents Phase 3
47 Mitogens Phase 2, Phase 3
48 Neurotransmitter Agents Phase 2, Phase 3
49 Excitatory Amino Acid Antagonists Phase 2, Phase 3
50 Anesthetics, Intravenous Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 280)
# Name Status NCT ID Phase Drugs
1 Insertional Achilles Tendinopathy: A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon Unknown status NCT01341509 Phase 4
2 A Single-blinded Randomized Controlled Trial Comparing Patients Who Receive a Corticosteroid Injection for Nontraumatic Degenerative Rotator Cuff Tears or Tendinopathy and Scheduled Use of a Dynamic Elastic Garment to Patients Who Receive a Corticosteroid Injection Alone. Unknown status NCT03032432 Phase 4 Corticosteroid injection
3 Functional Improvement and Ultrasound Tissue Characterisation of the Achilles Tendon Following Sodium Hyaluronate Injection for Plantaris Friction Syndrome Unknown status NCT03077009 Phase 4 Hyaluronic Acid
4 The Effect of Platelet Rich Plasma on Partial Thickness Rotator Cuff Tears: A Randomized Controlled Trial Completed NCT04743986 Phase 4 Corticosteroid (CS)
5 The Value of Platelet-Rich Plasma in Chronic Midportion Achilles Tendinopathy: a Double-blind Randomized Clinical Trial Completed NCT00761423 Phase 4
6 Placebo Controlled Trial, Testing the Efficacy of Polidocanol Injections as a Treatment of Chronic Achilles Tendinopathy. Completed NCT00377910 Phase 4 Aethoxysclerol
7 The Value of a High-Volume Image-Guided Injection in Chronic Midportion Achilles Tendinopathy: a Double-blind, Randomized, Placebo-controlled Clinical Trial Completed NCT02996409 Phase 4 HVIGI;LVIGI
8 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to a Single Intrabursal Injection of Corticosteroids in Patients With Shoulder Calcific Tendinopathy Completed NCT01652495 Phase 4 methylprednisolone acetate;Triamcinolone Acetonide
9 "NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control, Leg Stiffness and Functional Recovery in Athletes" Completed NCT00792376 Phase 4 etoricoxib;diclofenac
10 Shockwave Therapy of Chronic Achilles Tendinopathy. A Double-blind, Randomized Clinical Trial of Efficacy Completed NCT00958620 Phase 4
11 Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection: A Double Blind Controlled Study Completed NCT02403856 Phase 4 Sodium Chloride 0.9%;Methylprednisolone acetate
12 Radiofrequency-based Plasma Microdebridement Compared to Surgical Microdebridement for Treating Achilles Tendinosis: A Prospective, Randomized, Controlled Multi-Center Study" Completed NCT00534781 Phase 4
13 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer: A Prospective, Randomized, Controlled Trial Completed NCT00950053 Phase 4
14 A Prospective Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 50mg etanercept;25mg etanercept;placebo
15 Evaluation of Clinical Efficacy and Comparison of Autologous Platelet Rich Plasma, Hyaluronic Acid, Corticosteroid and Saline Injections for Treating Lateral and Medial Humeral Epicondylopathy Recruiting NCT04521387 Phase 4 Platelet Rich Plasma;Corticosteroid Injection;Hyaluronic Acid Injection
16 Collagen and PRP in Partial Thickness Rotator Cuff Injuries: Friends or Only Indifferent Neighbors: Randomized Controlled Trial Recruiting NCT04492748 Phase 4
17 Betamethason Versus Ketorolac Injection for the Treatment of DeQuervains Tenosynovitis Active, not recruiting NCT02604537 Phase 4 betamethasone;Ketorolac
18 Achilles Tendinopathy Treated With Heavy Slow Resistance Training Supplemented With Injection of Glucocorticosteroid or Local Anaesthetic. Active, not recruiting NCT02580630 Phase 4 Ultrasound guided injection with Glucocorticosteroid;Ultrasound guided injection with local anaestethic
19 Comparison of Leukocyte-rich Platelet Rich Plasma Injection to Percutaneous Tenotomy in the Treatment of Chronic Common Extensor Tendinopathy Not yet recruiting NCT04384809 Phase 4
20 Comparative Effectiveness of Particulate Versus Nonparticulate Corticosteroid Injections for the Treatment of Musculoskeletal Conditions Not yet recruiting NCT04278833 Phase 4 Triamcinolone or Betamethasone;Dexamethasone
21 Calcific Tendonitis Treatment: Barbotage vs. Barbotage With Cortisone Injection: A Randomized Controlled Double-Blind Study Not yet recruiting NCT04126278 Phase 4 Barbotage;Dexamethasone
22 Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial Suspended NCT04115644 Phase 4 Ketorolac;Marcaine (placebo);Kenalog
23 Ultrasound-Guided Platelet Rich Plasma Versus Whole Blood Injection for the Treatment of Gluteus Medius Tendinopathy: A Double-Blind Randomized Controlled Study Terminated NCT02978833 Phase 4
24 A Prospective Clinical Trial Comparing the Efficacy of Brisement to Physical Therapy for the Treatment of Achilles Tendinosis Withdrawn NCT03363789 Phase 4
25 "Clinical Evaluation of Placement of Radiofrequency-based Plasma Microdebridement in the Treatment Algorithm for Foot and Ankle Tendinosis and Plantar Fasciosis" Withdrawn NCT00420875 Phase 4
26 A Randomized Single Blinded Prospective Analysis for NSAID VS Corticosteroid Shoulder Injection in Diabetic Patients Withdrawn NCT03319784 Phase 4 Ketorolac;Triamcinolone Acetonide
27 Eccentric Training With Our Without Elbow Brace for Epicondylitis - a Randomized Clinical Trial Unknown status NCT01273688 Phase 3
28 Treatment of Subacromial Shoulder Pain Unknown status NCT01441830 Phase 3
29 Treatment for Achilles Tendinopathy Unknown status NCT00835939 Phase 2, Phase 3 25% Dextrose and 1% Lidocaine;Lidocaine
30 Clinical Multicenter, Phase III, Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Ibuprofen 50mg/g Gel in the Treatment of Patients With Muscle Pain, Joint, or Pain Caused by Sprains, Contusions, Tendinitis, or Myofascial Compared to Profenid ® 25mg/g. Gel Unknown status NCT01373697 Phase 3 Ibuprofen;Profenid
31 Multicenter, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety Aliviador Compared to Gelol in the Relief in Patients With Contusons, Sprains,Trauma and Muscle Injury. Unknown status NCT01097798 Phase 3 Aliviador;Gelol
32 Vibration Training in Epicondylitis - a Randomized Trial Unknown status NCT01269879 Phase 3
33 A Randomized Clinical Trial Comparing the Effectiveness of Subacromial Decompression (Acromioplasty) Versus Subacromial Bursectomy (no Acromioplasty) in the Arthroscopic Treatment of Patients With Rotator Cuff Tendinosis Unknown status NCT00196573 Phase 3
34 Clinical Multicenter Study, Randomized, Open, to Evaluate the Efficacy and Safety of Salonsip Compared to Sabiá Plaster Relief of the Signs and Symptoms in Patients With Contusions, Sprains, Injuries and Muscular Injuries With Less Than 24 Hours Early or Holders of Myalgia, Pain and Tendonitis in Regions Miofasciais Articulated. Unknown status NCT00970658 Phase 3 Salonsip plaster;Sabia plaster
35 Epidemiology of Incidents and Accidents in Sport. Influence of Moisture. Unknown status NCT02346786 Phase 3
36 Pilot Randomized Controlled Trial to Evaluate Safety and Efficacy of Percutaneous Needle Tenotomy With Platelet Rich Plasma (Leukocyte Depleted)in Epicondylitis Completed NCT01945528 Phase 3 US-guided tenotomy with PRP;US-guided tenotomy with lidocaine
37 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Diclofenac Sodium Patch for the Topical Treatment of Pain Due to Mild to Moderate Tendonitis or Bursitis Completed NCT00640939 Phase 2, Phase 3 diclofenac sodium;Matching Placebo
38 The Value of Autologous Tenocyte Implantation in Patients With Chronic Achilles Tendinopathy: a Double-blind Randomised Clinical Trial Completed NCT01343836 Phase 2, Phase 3
39 Role of Biological Therapy in Rotator Cuff Tendinopathy. Effectiveness of Plasma Rich in Growth Factors Regarding Functional Capacity and Pain Compared With the Conventional Treatment Using Steroids Completed NCT01915979 Phase 3 Celestone cronodose (Bethametasone)
40 Impact of Peripheral Pain Perception on Central Sensitization and Movement Strategies in Patients With Chronic Achilles Tendinopathy Completed NCT03316378 Phase 2, Phase 3 Ropivacaine injection
41 Analgesic Benefit of PECS Blocks for Biceps Tenodesis Shoulder Surgery Completed NCT02741713 Phase 3 Solution for Injection in Interscalene Block;Solution for Injection in Sham Block;Solution for Injection PECS Blocks
42 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Phase III Study of the Efficacy, Tolerability and Safety of Ketoprofen Topical Patch, 20% (KTP) in the Treatment of Pain Associated With Tendonitis or Bursitis of the Shoulder, Elbow or Knee Completed NCT00352625 Phase 3 Ketoprofen Topical Patch 20%
43 A Randomized, Multi-Center, Double-Blind, Placebo-Controlled Phase III Trial to Evaluate the Efficacy, Tolerability and Safety of MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder Completed NCT01161615 Phase 3 MRX-7EAT;Placebo
44 A Randomized, Multi-Center, Double-Blind, Placebo-Controlled Phase III Trial to Evaluate the Efficacy, Tolerability and Safety of MRX-7EAT Topical Patch in the Treatment of Pain Due to Recent Onset Supraspinatous and/or Subacromial Tendonitis/Bursitis and/or Subdeltoid Bursitis of Shoulder Completed NCT01506154 Phase 3 MRX-7EAT
45 Great Trochanteric Pain Syndrome: Parallel Group, Blind Randomised Clinical Trial to Assess the Efficacy and Safety of PRP Injection Versus Needle Tenotomy With Lidocaine Recruiting NCT04231357 Phase 3 platelet rich plasma
46 Does Subacromial Injection With Glutamate Receptor (NMDAR) Antagonist, Ketamine, Attenuate Pain in Rotator Cuff Tendinopathy? Recruiting NCT02967640 Phase 2, Phase 3 Ketalar;NaCl 9%
47 Use of Extended Release Triamcinolone in the Treatment of Rotator Cuff Disease Recruiting NCT04094298 Phase 3 FX006 Injection
48 Evaluation of Regenerative Medicine Treatment Outcomes With Amniotic Fluid for Musculoskeletal Conditions Recruiting NCT03390920 Phase 2, Phase 3
49 A Phase 3, Prospective, Double-Blinded, Randomized Controlled Trial Of The Micronized dHACM Injection As Compared To Saline Placebo Injection In The Treatment Of Achilles Tendonitis Active, not recruiting NCT03414255 Phase 3 Saline Injection
50 The Effect of Multiple Injection of Platlet-rich Plasma in Chronic Patellar Tendinopathy Not yet recruiting NCT03986372 Phase 2, Phase 3

Search NIH Clinical Center for Tendinopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Tendinopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tendinopathy:
Autologous tenocyte implantation for damaged tendons
Embryonic/Adult Cultured Cells Related to Tendinopathy:
Tenocytes PMIDs: 23314880 24068695

Genetic Tests for Tendinopathy

Anatomical Context for Tendinopathy

MalaCards organs/tissues related to Tendinopathy:

40
Bone, Spinal Cord, Bone Marrow, Whole Blood, Pituitary, Hypothalamus, Placenta

Publications for Tendinopathy

Articles related to Tendinopathy:

(show top 50) (show all 3834)
# Title Authors PMID Year
1
Atypical femoral fracture as the cause of greater trochanteric pain syndrome - a case report. 61
33598061 2021
2
Emerging Biological Treatment Methods for Ankle Joint and Soft Tissue Conditions: Clinical Applications as Alternative or Adjuvant. 61
33487242 2021
3
Participant characteristics are poorly reported in exercise trials in tendinopathy: A systematic review. 61
33360409 2021
4
Diagnosing Achilles tendinopathy is like delicious spaghetti carbonara: it is all about key ingredients, but not all chefs use the same recipe. 61
33055134 2021
5
Proximal hamstring tendinopathy; expert physiotherapists' perspectives on diagnosis, management and prevention. 61
33378733 2021
6
Which treatment is most effective for patients with Achilles tendinopathy? A living systematic review with network meta-analysis of 29 randomised controlled trials. 61
32522732 2021
7
Bicipital groove cross-sectional area on ultrasonography: Does a correlation to intra-articular tendon pathology exist? 61
33333282 2021
8
The plantaris muscle - Anatomical curiosity or a structure with important clinical value? - A comprehensive review of the current literature. 61
33561523 2021
9
Shear wave and strain sonoelastography for the evaluation of the Achilles tendon during isometric contractions. 61
33598763 2021
10
Normative Parameters of Gastrocnemius Muscle Stiffness and Associations with Patient Characteristics and Function. 61
33604133 2021
11
Scapular Motion in the Presence of Rotator Cuff Tears: A Systematic Review. 61
33540119 2021
12
Mycobacterium mageritense infection following mastectomy and breast reconstruction requiring triple antibiotic therapy and surgical debridement. 61
33542012 2021
13
Safety and Tolerability of Fluoroquinolones in Patients with Staphylococcal Periprosthetic Joint Infections. 61
33606003 2021
14
A Novel Murine Muscle Loading Model to Investigate Achilles Musculotendinous Adaptation. 61
33571057 2021
15
Metabolic Regulation of Tendon Inflammation and Healing Following Injury. 61
33569739 2021
16
UTE T2* mapping of tendinopathic patellar tendons: an MRI reproducibility study. 61
32340475 2021
17
Intra-Fascicular Chondroid-like Bodies in the Ageing Equine Superficial Digital Flexor Tendon comprise Glycosaminoglycans and Type II Collagen. 61
33580534 2021
18
2019 Marathon of Rome. Hamstring injuries in long distance runners: influence of age, gender, weight, height, numbers of marathon and impact profile. 61
33586934 2021
19
Proximal Hamstring Tendon Injuries: Diagnosis and Management. 61
33546782 2021
20
Diagnostic ultrasound in patients with shoulder pain: An inter-examiner agreement and reliability study among Dutch physical therapists. 61
33348286 2021
21
Low Molecular-weight Hyaluronic Acid Versus Physiotherapy for the Treatment of Supraspinatus Tendinopathy: A Randomized Comparative Clinical Trial. 61
33591125 2021
22
Effects of shockwave therapy on pain and disability in individuals with rotator cuff tendinopathy: a systematic review protocol. 61
33570316 2021
23
Platelet-Rich Plasma in Patients With Partial-Thickness Rotator Cuff Tears or Tendinopathy Leads to Significantly Improved Short-Term Pain Relief and Function Compared With Corticosteroid Injection: A Double-Blind Randomized Controlled Trial. 61
33127554 2021
24
Flexor hallucis longus hypertrophy secondary to Achilles tendon tendinopathy: an MRI-based case-control study. 61
33555443 2021
25
Translation, cross-cultural adaptation and validation of the Brazilian Portuguese version of the Victorian Institute of Sports Assessment for Gluteal Tendinopathy patient reported-outcome measure (VISA-G.BR). 61
33581429 2021
26
Effects of a "toes-off" modified heel raise on muscle coordination in non-dancers, dancers, and dancers with flexor hallucis longus tendinopathy. 61
33601167 2021
27
Biomechanical Comparison of All-Soft Suture Anchor Single-Row vs Double-Row Bridging Construct for Insertional Achilles Tendinopathy. 61
33030070 2021
28
High- Versus Low-Molecular-Weight Hyaluronic Acid for the Treatment of Rotator Cuff Tendinopathy: A Triple-Blind Randomized Comparative Trial. 61
33567859 2021
29
Line- and Point-Focused Extracorporeal Shock Wave Therapy for Achilles Tendinopathy: A Placebo-Controlled RCT Study. 61
33586526 2021
30
Telehealth sounds a bit challenging, but it has potential: participant and physiotherapist experiences of gym-based exercise intervention for Achilles tendinopathy monitored via telehealth. 61
33541314 2021
31
A comparative study of treatment interventions for patellar tendinopathy: a randomized controlled trial. 61
33556350 2021
32
Endoscopic Flexor Hallucis Longus Transfer for Achilles Noninsertional Tendinopathy: Description of Surgical Technique and Functional Outcomes. 61
31916453 2021
33
Endoscopic speed bridge: a new treatment for insertional Achilles tendinopathy. 61
33578040 2021
34
French Translation and Validation of the Victorian Institute of Sports Assessment for Gluteal Tendinopathy Questionnaire. 61
32323468 2021
35
Diagnostic criteria for musculoskeletal disorders for use in occupational healthcare or research: a scoping review of consensus- and synthesised-based case definitions. 61
33573616 2021
36
Immediate and long-term effects of mechanical loading on Achilles tendon volume: A systematic review and meta-analysis. 61
33556887 2021
37
Author Correction: Tendinopathy. 61
33536420 2021
38
Does balneotherapy provide additive effects to physical therapy in patients with subacute supraspinatus tendinopathy? A randomized, controlled, single-blind study. 61
33089368 2021
39
Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy. 61
33603790 2021
40
Hip Pain in Adults: Evaluation and Differential Diagnosis. 61
33448767 2021
41
Video-based biomechanical analysis of an unexpected Achilles tendon rupture in an Olympic sprinter. 61
33493708 2021
42
The Patient-Rated Tennis Elbow Evaluation Questionnaire was successfully translated to Persian. 61
32156573 2021
43
Intramuscular injection of Botox causes tendon atrophy by induction of senescence of tendon-derived stem cells. 61
33413592 2021
44
MRI features of and factors related to ankle injuries in asymptomatic amateur marathon runners. 61
32632469 2021
45
Small interfering RNAs in tendon homeostasis. 61
33454750 2021
46
Association between anterior talofibular ligament injury and ankle tendon, ligament, and joint conditions revealed by magnetic resonance imaging. 61
33392013 2021
47
The Use of Biologics for Hip Preservation. 61
33483876 2021
48
The Utility of SPECT/CT in Diagnosing Haglund Syndrome With Bone Scintigraphy. 61
33086279 2021
49
Effectiveness of Focused Shockwave Therapy versus Radial Shockwave Therapy for Noncalcific Rotator Cuff Tendinopathies: A Randomized Clinical Trial. 61
33506031 2021
50
Stress-deprivation induces an up-regulation of versican and connexin-43 mRNA and protein synthesis and increased ADAMTS-1 production in tendon cells in situ. 61
33467936 2021

Variations for Tendinopathy

Expression for Tendinopathy

Search GEO for disease gene expression data for Tendinopathy.

Pathways for Tendinopathy

Pathways related to Tendinopathy according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 MMP8 MMP3 MMP1 COL5A1 CASP3
2
Show member pathways
11.96 MMP3 MMP1 CASP8 CASP3
3
Show member pathways
11.95 MMP3 MMP1 CASP3
4 11.8 MMP1 CASP8 CASP3
5
Show member pathways
11.75 TIMP2 MMP8 MMP3 MMP1 COL5A1 CASP3
6 11.63 MMP3 CASP8 CASP3
7
Show member pathways
11.35 MMP3 MMP1
8 11.33 TIMP2 MMP3 MMP1
9 11.29 CASP8 CASP3
10
Show member pathways
11.25 CASP8 CASP3
11
Show member pathways
11.25 TIMP2 MMP8 MMP3 MMP1
12 11.22 MMP1 CASP3
13 11.17 CASP8 CASP3
14 11.1 MMP1 CASP8 CASP3
15 10.92 TIMP2 MMP3 MMP1

GO Terms for Tendinopathy

Cellular components related to Tendinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 TIMP2 MMP8 MMP3 ENPP1 COL5A1
2 extracellular region GO:0005576 9.63 TIMP2 MMP8 MMP3 MMP1 ENPP1 COL5A1
3 collagen-containing extracellular matrix GO:0062023 9.58 TIMP2 MMP8 COL5A1
4 specific granule lumen GO:0035580 9.37 TIMP2 MMP8
5 tertiary granule lumen GO:1904724 9.32 TIMP2 MMP8
6 extracellular matrix GO:0031012 9.02 TIMP2 MMP8 MMP3 MMP1 COL5A1
7 death-inducing signaling complex GO:0031264 8.96 CASP8 CASP3

Biological processes related to Tendinopathy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 MMP3 MMP1 CASP3
2 extracellular matrix organization GO:0030198 9.56 MMP8 MMP3 MMP1 COL5A1
3 proteolysis GO:0006508 9.55 MMP8 MMP3 MMP1 CASP8 CASP3
4 positive regulation of protein complex assembly GO:0031334 9.51 MMP3 MMP1
5 response to tumor necrosis factor GO:0034612 9.48 CASP8 CASP3
6 response to antibiotic GO:0046677 9.46 CASP8 CASP3
7 execution phase of apoptosis GO:0097194 9.43 CASP8 CASP3
8 regulation of neuroinflammatory response GO:0150077 9.4 MMP8 MMP3
9 cellular response to UV-A GO:0071492 9.37 MMP3 MMP1
10 response to cobalt ion GO:0032025 9.32 CASP8 CASP3
11 collagen catabolic process GO:0030574 9.13 MMP8 MMP3 MMP1
12 extracellular matrix disassembly GO:0022617 8.92 TIMP2 MMP8 MMP3 MMP1

Molecular functions related to Tendinopathy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.67 MMP8 MMP3 MMP1
2 metallopeptidase activity GO:0008237 9.65 MMP8 MMP3 MMP1
3 hydrolase activity GO:0016787 9.63 MMP8 MMP3 MMP1 ENPP1 CASP8 CASP3
4 metalloendopeptidase activity GO:0004222 9.5 MMP8 MMP3 MMP1
5 death receptor binding GO:0005123 9.46 CASP8 CASP3
6 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.43 CASP8 CASP3
7 endopeptidase activity GO:0004175 9.43 MMP8 MMP3 MMP1
8 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.4 CASP8 CASP3
9 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.37 CASP8 CASP3
10 zinc ion binding GO:0008270 9.35 TIMP2 MMP8 MMP3 MMP1 ENPP1
11 peptidase activity GO:0008233 9.02 MMP8 MMP3 MMP1 CASP8 CASP3

Sources for Tendinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
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30 HMDB
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32 ICD10
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57 OMIM® (Updated 05-Mar-2021)
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