Tenosynovial Giant Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: TNS001 MIFTS: 38	Tenosynovial Giant Cell Tumor Categories: Cancer diseases, Muscle diseases
Genes Tissues Related diseases Publications Pathways Drugs Download Expand all tables

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Aliases & Classifications for Tenosynovial Giant Cell Tumor

MalaCards integrated aliases for Tenosynovial Giant Cell Tumor:

Name: Tenosynovial Giant Cell Tumor ¹² ¹⁵

Fibrous Histiocytoma of Tendon Sheath ¹² ⁷³

Giant Cell Tumor of Tendon Sheath ¹²

Giant Cell Tumor of Tenosynovium ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Muscle diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:314

ICD9CM ³⁵ 727.02

NCIt ⁵⁰ C3402

SNOMED-CT ⁶⁸ 128777004 310605004 71508003 more

UMLS ⁷³ C1318543

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Summaries for Tenosynovial Giant Cell Tumor

MalaCards based summary : Tenosynovial Giant Cell Tumor, also known as fibrous histiocytoma of tendon sheath, is related to pigmented villonodular synovitis and giant cell tumor. An important gene associated with Tenosynovial Giant Cell Tumor is CSF1 (Colony Stimulating Factor 1), and among its related pathways/superpathways are Dendritic Cells Developmental Lineage Pathway and Validated targets of C-MYC transcriptional repression. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, salivary gland and brain.

Wikipedia : ⁷⁶ Giant-cell tumor of the tendon sheath, also known as giant-cell synovioma and localized nodular... more...

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Related Diseases for Tenosynovial Giant Cell Tumor

Diseases related to Tenosynovial Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)

#	Related Disease	Score	Top Affiliating Genes
1	pigmented villonodular synovitis	33.3	CSF1 CSF1R
2	giant cell tumor	31.4	CSF1 SERPINA3
3	synovitis	10.5
4	villonodular synovitis	10.5
5	thyroid lymphoma	10.4	CDKN2A CDKN2B
6	atypical neurofibroma	10.4	CDKN2A CDKN2B
7	acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	10.4	CSF1 CSF1R
8	ewing's family of tumors	10.4	CDKN2A CDKN2B
9	acute lymphoblastic leukemia, childhood	10.3	CDKN2A CDKN2B
10	grade iii astrocytoma	10.2	CDKN2A CDKN2B
11	leukemia, acute lymphoblastic 3	10.2	CDKN2A CDKN2B
12	fibrosarcoma of bone	10.2	CDKN2A SERPINA3
13	melanoma, cutaneous malignant 1	10.1	CDKN2A CDKN2B
14	nodular tenosynovitis	10.1
15	tenosynovitis	10.1
16	histiocytosis	10.0	CSF1R SERPINA3
17	nervous system cancer	10.0	CDKN2A CDKN2B
18	noonan syndrome 1	9.9
19	rheumatoid arthritis	9.9
20	arthritis	9.9
21	lymphoma	9.9
22	thyroid cancer	9.9
23	cervicitis	9.9
24	thyroiditis	9.9
25	pseudo-turner syndrome	9.9
26	retinal hemangioblastoma	9.9	CLU SERPINA3
27	hematologic cancer	9.9	CDKN2B CSF1 CSF1R
28	scrotal carcinoma	9.8	CDKN2A CDKN2B SERPINA3
29	malignant histiocytosis	9.8	CSF1 CSF1R SERPINA3
30	myelodysplastic syndrome	9.8	CDKN2B CSF1 CSF1R
31	anaplastic large cell lymphoma	9.5	CLU CSF1R
32	congenital disorder of glycosylation, type in	9.2	CLU PGM1

Graphical network of the top 20 diseases related to Tenosynovial Giant Cell Tumor:

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Symptoms & Phenotypes for Tenosynovial Giant Cell Tumor

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Drugs & Therapeutics for Tenosynovial Giant Cell Tumor

Drugs for Tenosynovial Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Antibodies

Phase 1, Phase 2

Immunoglobulins

Phase 1, Phase 2

Grapefruit Seed Extract

Nutraceutical

Phase 2

Paclitaxel

Approved, Vet_approved

Phase 1

33069-62-4

36314

Synonyms:

(2AR-(2aalpha,4b,4abeta,6b,9a(a r*,betas*),11a,12a,12balpha))-b-(benzoylamino)-a-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4b,4abeta,6b,9a(a r*,betas*),11a,12a,12balpha))-b-(benzoylamino)-a-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4β,4abeta,6β,9α(α r*,betas*),11α,12α,12balpha))-β-(benzoylamino)-α-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4β,4abeta,6β,9α(α r*,betas*),11α,12α,12balpha))-β-(benzoylamino)-α-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

157069-30-2

33069-62-4

5b,20-Epoxy-1,2-a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5b,20-Epoxy-1,2-a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5β,20-epoxy-1,2-α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5β,20-epoxy-1,2-α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

7 Epi taxol

7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.

7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.

7-epi-Paclitaxel

7-Epipaclitaxel

7-Epi-paclitaxel

7-epi-Taxol

7-Epitaxol

7-Epi-taxol

AB00513812

ABI 007

abi-007

ABI007

ABI-007

Abraxane

Abraxane (TN)

Abraxane I.V. Suspension

Abraxis BioScience brand of albumin-bound paclitaxel

AC1L1IOG

AC1L1VJI

AC1L9AVF

AC-675

ACon1_002231

albumin-bound paclitaxel

Ambotz33069-62-4

ANX-513

Anzatax

Asotax

BIDD:PXR0046

Bio-0076

Bio1_000362

Bio1_000851

Bio1_001340

Bio2_000416

Bio2_000896

BMS 181339-01

BMS-181339

BMS-181339-01

BPBio1_000320

BRD-A23723433-001-01-2

BRD-A28746609-001-04-0

BRD-K62008436-001-03-1

Bris taxol

Bristaxol

BSPBio_000290

BSPBio_001152

BSPBio_002614

C07394

C466458

C47H51NO14

Capxol

CCRIS 8143

CHEBI:103439

CHEBI:45863

CHEMBL100910

CHEMBL418410

CHEMBL48

CID36314

CID441276

CID4666

CID6713921

CID6915727

cMAP_000068

CPD-8718

D00491

DB01229

DHP-107

DHP-208

DivK1c_000441

DRG-0190

DTS-301

Ebetaxel

EmPAC

Epitaxol

EU-0101201

Genaxol

Genetaxyl

Genexol

Genexol-PM

HMS1362J13

HMS1568O12

HMS1792J13

HMS1922K08

HMS1990J13

HMS2090D07

HMS2093K15

HMS501G03

HSDB 6839

I06-0014

IDI1_000441

IDI1_002171

Intaxel

KBio1_000441

KBio2_000492

KBio2_002016

KBio2_002509

KBio2_003060

KBio2_004584

KBio2_005077

KBio2_005628

KBio2_007152

KBio2_007645

KBio3_000903

KBio3_000904

KBio3_001834

KBio3_002987

KBioGR_000492

KBioGR_001893

KBioGR_002509

KBioSS_000492

KBioSS_002016

KBioSS_002517

LipoPac

LMPR0104390001

Lopac0_001201

LS-31070

MBT 0206

MEGxp0_001940

Micellar Paclitaxel

Mitotax

MLS000863266

MLS001077297

MLS002154218

MLS002172439

MLS002695976

MolPort-001-742-627

MolPort-003-665-783

MolPort-003-932-365

MPI-5018

nab-paclitaxel

Nanotaxel

NCGC00024995-02

NCGC00024995-03

NCGC00024995-04

NCGC00024995-05

NCGC00024995-06

NCGC00024995-07

NCGC00164367-01

NCGC00164367-02

NCGC00164367-03

nchembio.188-comp1

nchembio.2007.34-comp9

nchembio.215-comp9

nchembio853-comp6

NCI60_000601

Neuro_000060

NINDS_000441

NK 105

Nova-12005

NP-010981

NSC 125973

NSC125973

NSC-125973

NSC358882

OAS-PAC-100

OncoGel

Onxal

Onxol

Onxol, Taxol, Nov-Onxol, Paclitaxel

P1632

Paclical

Pacligel

paclitaxel

Paclitaxel

Paclitaxel (JAN/USP)

Paclitaxel (JAN/USP/INN)

Paclitaxel (Taxol)

Paclitaxel [USAN:INN:BAN]

Paclitaxel, (4 alpha)-isomer

Paxceed

Paxene

Paxoral

Plaxicel

Praxel

Prestwick0_000155

Prestwick1_000155

Prestwick2_000155

Prestwick3_000155

Probes2_000350

QW 8184

S1150_Selleck

S-8184 Paclitaxel Injectable Emulsion

SDCCGMLS-0066823.P001

SDP-013

SMP1_000228

SMR000394086

SMR000857385

SPBio_000943

SPBio_002229

Spectrum_001536

SPECTRUM1503908

Spectrum2_000872

Spectrum3_001057

Spectrum4_001197

Spectrum5_001491

ST50306996

T 7402

T1912_SIGMA

T7191_SIGMA

T7402_SIGMA

TA1

TaxAlbin

Taxol

TAXOL

TAXOL (TN)

Taxol a

Taxol A

Taxol Konzentrat

TAXOL, 10-EPI,

Taxol, bris

Taxol.RTM. (Registered Trademark)

TXL

UNII-P88XT4IS4D

UPCMLD-DP108:001

UPCMLD-DP108:002

Vascular Wrap

weekly paclitaxel

Xorane

Yewtaxan

Midazolam

Approved, Illicit

Phase 1

59467-70-8

4192

Synonyms:

4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate

59467-70-8

8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride

8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine

8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine

AC-18749

AC1L1HMA

BIDD:GT0647

BRN 0625572

Buccolam

C07524

C18H13ClFN3

CHEMBL655

CID4192

D00550

Dazolam

DB00683

Dea no. 2884

Dea No. 2884

DEA No. 2884

Dormicum

Dormicum (TN)

EINECS 261-774-5

Hydrochloride, midazolam

LS-77780

Maleate, midazolam

Midanium

midazolam

Midazolam

Midazolam (JAN/INN)

Midazolam [INN:BAN:JAN]

Midazolam base

Midazolam Base

Midazolam Hcl

Midazolam hydrochloride

Midazolam maleate

Midazolamum

Midazolamum [INN-Latin]

Midosed

MolPort-003-849-219

NCGC00168254-01

nchembio747-comp32

Ro 21-3981

TL8003787

UC429_SIGMA

UNII-R60L0SM5BC

Versed

ZINC00001732

Warfarin

Approved

Phase 1

81-81-2

6691 54678486

Synonyms:

(-)-Warfarin

(Phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarin

(Phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine

(S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone

(S)-Warfarin

1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone

200 coumarin

200 Coumarin

3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin

3-(Acetonylbenzyl)-4-hydroxycoumarin

3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin

3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin

3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin

45706_FLUKA

45706_RIEDEL

4-Hydroxy-3- (3-oxo-1-fenyl-butyl) cumarine

4-Hydroxy-3- (3-oxo-1-phenyl-butyl)-cumarin

4-Hydroxy-3-(3-oxo-1-fenyl-butyl) cumarine

4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one

4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one

4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin

4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin

4-Idrossi-3- (3-oxo-)-fenil-butil)-cumarine

4-Idrossi-3-(3-oxo-)-fenil-butil)-cumarine

4-Idrossi-3-(3-oxo-1-fenil-butil)-cumarine

4oh-Coumarin deriv.

5543-56-6

5543-57-7

81-81-2

A2250_FLUKA

A2250_SIGMA

AC-15978

AC1L1N37

AC1Q6AN3

aldo Brand OF warfarin sodium

Aldocumar

Antigen brand OF warfarin sodium

Apotex brand OF warfarin sodium

apo-Warfarin

AR-1E2310

Arab rat death

Arab Rat Death

Arab rat deth

Athrombin

Athrombine-K

Athrombin-K

Bailly brand OF warfarin sodium

Bio-0586

Boots brand OF warfarin sodium

BRD-A24514565-001-02-2

BRD-A24514565-236-01-6

Bristol-myers squibb brand OF warfarin sodium

BRN 1293536

Brumolin

BSPBio_002026

C01541

C19H16O4

Caswell No. 903

CBDivE_002127

CBDivE_013236

CBKinase1_000192

CBKinase1_012592

CHEBI:10033

CHEMBL1464

Choice

Choice (TN)

CID6691

Compound 42

Co-Rax

CO-Rax

Coumadin

Coumadin Tabs

Coumadine

Coumafen

Coumafene

Coumafene [French]

Coumaphen

Coumaphene

Coumarins

Coumefene

Cov-R-tox

Cov-R-Tox

D08682

DB00682

D-Con

D-CON

delta-CON

Dethmor

Dethnel

Dicusat e

Dicusat E

DivK1c_000444

DL-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin

Eastern states duocide

EINECS 201-377-6

EINECS 226-907-3

EPA Pesticide Chemical Code 086002

Estedi brand OF warfarin sodium

fasco Fascrat powder

Fasco fascrat powder

Frass-ratron

Frass-Ratron

Genpharm brand OF warfarin sodium

Gen-warfarin

Goldshield brand OF warfarin sodium

HMS1921K07

HMS2092C20

HMS501G06

HSDB 1786

I14-0958

IDI1_000444

Jantoven

KBio1_000444

KBio2_000674

KBio2_003242

KBio2_005810

KBio3_001526

KBioGR_000901

KBioSS_000674

Killgerm sewarin P

Kumader

Kumadu

Kumatox

Kypfarin

Latka 42

Latka 42 [Czech]

Liqua-tox

LS-55083

Maag rattentod cum

Maag Rattentod Cum

Marevan

Mar-frin

Mar-Frin

Martin's mar-frin

Martin'S mar-frin

Maveran

MLS001304042

MolPort-001-787-822

Mouse pak

NCGC00094810-01

NCGC00094810-02

NCGC00159398-03

NCGC00178855-01

nchembio.307-comp19

NINDS_000444

NSC 59813

NSC59813

Panwarfin

Place-pax

Place-Pax

Potassium, warfarin

Prothromadin

PS104_SUPELCO

rac-Warfarin

Rat & mice bait

Rat and mice bait

Rat-alpha-way

Rat-a-way

Rat-beta-gon

Rat-b-gon

Rat-B-gon

Rat-gard

Rat-Gard

Rat-kill

Rat-Kill

Rat-mix

Rat-Mix

Rat-o-cide #2

Rat-O-cide #2

Rat-O-cide no. 2

Rat-ola

Rat-Ola

Ratorex

Ratox

Ratoxin

Ratron

Ratron g

Ratron G

Rats-no-more

Rats-NO-more

Ratten-koederrohr

Ratten-Koederrohr

Rattenstreupulver neu schacht

Rattenstreupulver Neu Schacht

Rattenstreupulver new schacht

Rattentraenke

Rat-trol

Rat-Trol

Rattunal

RAX

RCR Grey squirrel killer concentrate

RCRA waste no. P001

Rcra waste number P001

Rodafarin

Rodafarin c

Rodafarin C

ro-Deth

Ro-Deth

Rodex

Rodex blox

Rosex

Rough & ready mouse mix

Rough and ready mouse mix

Sakarat

Sewarin

SMP1_000316

SMR000718754

Sodium, warfarin

Sofarin

Solfarin

Sorexa plus

Sorexa Plus

SPBio_000870

Spectrum_000194

SPECTRUM1500613

Spectrum2_000935

Spectrum3_000583

Spectrum4_000381

Spectrum5_001751

Spray-trol brand roden-trol

STK364490

Tedicumar

Temus W

Tintorane

Tox-hid

Tox-Hid

Twin light rat away

UNII-5Q7ZVV76EI

Vampirinip II

Vampirinip iii

Vampirinip III

W.A.R.F. 42

Waran

Warf 10

Warf 42

WARF compound 42

Warfant

Warfarat

warfarin

Warfarin (and salts of)

Warfarin (INN)

Warfarin [BSI:ISO]

Warfarin [INN:BAN]

Warfarin plus

Warfarin Plus

Warfarin plus [discontinued]

Warfarin potassium

Warfarin Q

Warfarin sodium

Warfarin titrated to an INR of 2.5-3.0

Warfarin(R)

Warfarina

Warfarina [INN-Spanish]

Warfarine

Warfarine [INN-French]

Warfarine [ISO-French]

Warfarinum

Warfarinum [INN-Latin]

Warficide

Warfilone

WLN: T66 BOVJ DYR&1V1 EQ

Zoocoumarin

Zoocoumarin [Netherlands and USSR]

Zoocoumarin [Russian]

Menadione

Approved, Nutraceutical

Phase 1

58-27-5

4055

Synonyms:

03AAE1E9-B215-45AF-976C-91E61894A467

1,4-Naphthalenedione, 2-methyl-, radical ion(1-)

2-Methyl-1,4-naftochinon

2-Methyl-1,4-naftochinon [Czech]

2-Methyl-1,4-naphthalendione

2-Methyl-1,4-naphthalenedione

2-Methyl-1,4-Naphthalenedione

2-Methyl-1,4-naphthochinon

2-Methyl-1,4-naphthochinon [German]

2-Methyl-1,4-naphthodione

2-Methyl-1,4-naphthoquinone

2-methyl-1,4-naphthoquinone, 5

2-methylnaphthalene-1,4-dione

2-Methylnaphthoquinone

34524-96-4

3-Methyl-1,4-naphthoquinone

47775_SUPELCO

58-27-5

72060-21-0

AC1L1HBA

AC1Q2HB3

AI3-14700

AKOS004910447

Aquakay

Aquinone

ARONIS24154

BB_NC-2319

BIDD:ER0556

Bio1_000471

Bio1_000960

Bio1_001449

Bisulfite, menadione

Bisulfite, menadione sodium

BPBio1_000592

BSPBio_000538

C05377

C11H8O2

CAS-58-27-5

CCRIS 6672

CHEBI:28869

CHEMBL590

CID4055

cMAP_000077

CPD-3766

D02335

DB00170

DivK1c_000080

DivK1c_006287

EINECS 200-372-6

Hemodal

HMS1569K20

HMS1921P06

HMS2092F12

HMS500D22

HSDB 3354

I14-2821

IDI1_000080

InChI=1/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H

Juva-K

Kaergona

Kanone

Kappaxan

Kappaxan (VAN)

Kappaxin

Kappaxin (TN)

Karcon

Kareon

Kativ-g

Kativ-G

Kayklot

Kaykot

Kaynone

Kayquinone

KBio1_000080

KBio1_001231

KBio2_001708

KBio2_002527

KBio2_004276

KBio2_005095

KBio2_006844

KBio2_007663

KBio3_003005

KBioGR_000984

KBioGR_002527

KBioSS_001708

KBioSS_002535

Kipca

Kipca, oil soluble

Kipca-oil soluble

Kipca-Oil Soluble

Klottone

Koaxin

Kolklot

K-Thrombyl

K-Vitan

LS-95653

LS-95654

M0373

M5625_SIGMA

M9429_SIGMA

Memodol

Menadion

menadione

Menadione

Menadione (K3)

Menadione (USP)

Menadione [USAN:BAN]

Menadione bisulfite

Menadione semiquinone

Menadione sodium bisulfite

Menadione sodium bisulfite, trihydrate

Menadionum

Menaphthene

Menaphthon

Menaphthone

Menaphtone

Menaquinone

Menaquinone 0

Menaquinone O

Methyl-1,4-naphthalenedione

Methyl-1,4-naphthoquinone

Methylnaphthoquinone

Mitenon

Mitenone

MLS000069420

MLS001148443

MNQ

MolPort-001-766-699

NCGC00016258-01

NCGC00094978-01

NCGC00094978-02

nchembio.109-comp5

NCI60_003945

NCIMech_000105

NINDS_000080

NSC 4170

NSC4170

Panosine

Prestwick_313

Prestwick0_000459

Prestwick1_000459

Prestwick2_000459

Prestwick3_000459

Prokayvit

QTL1_000056

S1949_Selleck

SMR000059102

SMR000653532

Sodium bisulfite, menadione

SPBio_001267

SPBio_002477

SpecPlus_000191

Spectrum_001228

SPECTRUM1502254

Spectrum2_001194

Spectrum4_000722

Spectrum5_001764

Synkay

Thyloquinone

UNII-723JX6CXY5

Usaf ek-5185

Vicasol

Vikasol

Vitamin K 3

Vitamin K0

Vitamin K2

Vitamin K2(0)

Vitamin K3

Vitamin K3 : 2-Methyl-1,4-naphthoquinone

Vitamin K3 sodium bisulfite

Vitamin K3: 1,4-dihydro-1,4-dioxo-2-methylnaphthalene

Vitamin-?K3

VK3

WLN: L66 BV EVJ C1

ZINC00001677

Phytonadione

Approved, Investigational, Nutraceutical

Phase 1

84-80-0

4812 5284607

Synonyms:

.alpha.-Phylloquinone

1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-, radical ion(1-)

10485-69-5

11104-38-4

15973-57-6

2-(3,7,11,15-Tetramethylhexadec-2-enyl)-3-methylnaphthalene-1,4-dione

2', 3'-trans-Vitamin K1

2',3'-trans-Vitamin K1

27696-10-2

2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalened- ione

2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione

2-methyl-3-(3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione

2-Methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)-1,4-naphthoquinone

2-Methyl-3-[(2e)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone

2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone

2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione

2-Methyl-3-phythyl-1,4-naphthochinon

2-Methyl-3-phytyl-1,4-naphthochinon

2-Methyl-3-phytyl-1,4-naphthochinon [German]

2-Methyl-3-phytyl-1,4-naphthoquinone

2-METHYL-3-PHYTYL-14-NAPHTHOQUINONE

3-Phytylmenadione

50926-17-5

84-80-0

AC1NQX34

AC1Q6B3J

alpha-Phylloquinone

Antihemorrhagic vitamin

a-Phylloquinone

Aqua mephyton

Aqua-Mephytin

Aquamephyton

AR-1E3503

C02059

C31H46O2

CID5280483

Combinal K1

D00148

DB01022

EINECS 201-564-2

EINECS 234-330-3

EINECS 279-833-9

Fitomenadiona

Fitomenadiona [INN-Spanish]

Fitomenadione

Fitomenadione [DCIT]

HSDB 3162

Kativ N

Kephton

Kinadion

K-Ject

Konakion

LS-94617

LT00452032

Mephyton

Mephyton (TN)

MLS001332659

MLS001332660

MolPort-001-785-978

Monodion

Mono-Kay

NCGC00159423-02

NSC 270681

NSC270681

P0642

Phyllochinon

Phyllochinon [German]

Phyllochinonum

phyllohydroquinone

Phyllohydroquinone

Phylloquinone

Phylloquinone (8CI)

Phythyl-menadion

Phythyl-menadion (GERMAN)

Phytomenadione

Phytomenadione (INN)

Phytomenadionum

Phytomenadionum [INN-Latin]

phytonadione

Phytonadione (JP15/USP)

Phytonadione [USAN:JAN]

Phytonadionum

Phytylmenadione

SMR000059144

ST075162

Synthex P

trans-Phylloquinone

UNII-A034SE7857

Vitamin k

VITAMIN K

Vitamin K 1

Vitamin K hydroquinone (phylloquinone)

Vitamin K1

VITAMIN K1

Vitamin K1 (generic)

Vitamin K1 (TN)

Vitamin K1 (VAN)

Vitamin K1(20)

α-phylloquinone

Albumin-Bound Paclitaxel

Phase 1

Antimitotic Agents

Phase 1

Antineoplastic Agents, Phytogenic

Phase 1

Adjuvants, Anesthesia

Phase 1

Anesthetics

Phase 1

Anesthetics, General

Phase 1

Anesthetics, Intravenous

Phase 1

Anti-Anxiety Agents

Phase 1

Anticoagulants

Phase 1

Antifibrinolytic Agents

Phase 1

Central Nervous System Depressants

Phase 1

Coagulants

Phase 1

GABA Agents

Phase 1

GABA Modulators

Phase 1

Hemostatics

Phase 1

Hypnotics and Sedatives

Phase 1

Micronutrients

Phase 1

Neurotransmitter Agents

Phase 1

Psychotropic Drugs

Phase 1

Trace Elements

Phase 1

Tranquilizing Agents

Phase 1

Vitamins

Phase 1

Menaquinone

Nutraceutical

Phase 1

naphthoquinone

Nutraceutical

Phase 1

Vitamin K

Nutraceutical

Phase 1

Interventional clinical trials:

(show all 11)

#	Name	Status	NCT ID	Phase	Drugs
1	Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)	Active, not recruiting	NCT02371369	Phase 3	Pexidartinib;Placebo
2	Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)	Completed	NCT01261429	Phase 2	Tasigna
3	Study of Cabiralizumab in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor	Recruiting	NCT02471716	Phase 1, Phase 2
4	Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor	Active, not recruiting	NCT01207492	Phase 2	nilotinib
5	MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS)	Active, not recruiting	NCT01643850	Phase 2	MCS110;Placebo;MCS110;Placebo
6	A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors	Completed	NCT01494688	Phase 1	Paclitaxel;RO5509554
7	Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics)	Recruiting	NCT03291288	Phase 1	Tolbutamide;Midazolam;Pexidartinib
8	A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor	Terminated	NCT02673736	Phase 1	PLX73086
9	Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors	Terminated	NCT01804530	Phase 1	PLX7486 TsOH
10	Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project	Recruiting	NCT02948088
11	Evaluation of the Effectiveness of Surgical Treatment of Villo-nodular Synovitis of the Hip in Children	Recruiting	NCT03507933

Search NIH Clinical Center for Tenosynovial Giant Cell Tumor

Sources

Genetic Tests for Tenosynovial Giant Cell Tumor

Sources

Anatomical Context for Tenosynovial Giant Cell Tumor

MalaCards organs/tissues related to Tenosynovial Giant Cell Tumor:

⁴¹

Bone, Salivary Gland, Brain, Thyroid

Sources

Publications for Tenosynovial Giant Cell Tumor

Articles related to Tenosynovial Giant Cell Tumor:

(show top 50) (show all 86)

#	Title	Authors	Year
1	Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. ( 29637236 )	Kim D.E....Bin S.I.	2018
2	Extra-articular tenosynovial giant cell tumor of diffuse type in the temporal area with brain parenchymal invasion: a case report. ( 29334779 )	Son S.M....Woo C.G.	2018
3	Successful treatment of a diffuse type tenosynovial giant cell tumor in the thoracic spine mimicking spinal metastasis by frozen recapping laminoplasty in a patient with thyroid cancer. ( 29663145 )	Yonezawa N....Tsuchiya H.	2018
4	Multifocal tenosynovial giant cell tumors in a child with Noonan syndrome. ( 27878339 )	Meyers A.B....Szabo S.	2017
5	Extra-articular diffuse-type tenosynovial giant cell tumor with benign histological features resulting in fatal pulmonary metastases. ( 28219303 )	Osanai T....Nojima T.	2017
6	Chondroid Tenosynovial Giant Cell Tumor of the Temporomandibular Joint: A Rare Case Report. ( 29215692 )	Anbinder A.L....Carvalho Y.R.	2017
7	Imaging features for diffuse-type tenosynovial giant cell tumor of the temporomandibular joint: A case report. ( 28658169 )	Hu Y....Shu J.	2017
8	Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )	Gouin F....Noailles T.	2017
9	Tenosynovial Giant Cell Tumor: Incidence, Prevalence, Patient Characteristics, and Recurrence. A Registry-based Cohort Study in Denmark. ( 28765257 )	Ehrenstein V....Acquavella J.F.	2017
10	Tenosynovial Giant Cell Tumor in the Midfoot Treated With Femoral Head Allograft Reconstruction. ( 28864387 )	Fuchs D.J....Kadakia A.R.	2017
11	Pitfalls in the cytological diagnosis of tenosynovial giant cell tumor: An illustration of eight discordant cases. ( 28941190 )	Mondal K....Chakraborty J.	2017
12	Prognosis of Advanced Tenosynovial Giant Cell Tumor of the Knee Diagnosed During Total Knee Arthroplasty. ( 28161138 )	Lei P....Hu Y.	2017
13	Fine needle aspiration cytology diagnosis of metastatic malignant diffuse type tenosynovial giant cell tumor. ( 28701836 )	Ramteke P....Mridha A.R.	2017
14	Tenosynovial Giant Cell Tumor in the Dermis of the External Auditory Meatus. ( 27072732 )	Maghari A....Lambert W.C.	2016
15	Coexisting sarcoidal granulomatous inflammation and diffuse tenosynovial giant cell tumor of the knee after a total knee replacement: a case report. ( 27717976 )	Zhang Y....Bauer T.W.	2016
16	Pediatric Intra-Articular Localized Tenosynovial Giant Cell Tumor Presenting as an Acutely Irritable Hip: A Case Report. ( 29252637 )	Saadat E....Glotzbecker M.	2016
17	Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. ( 26820289 )	Brahmi M....Cassier P.A.	2016
18	Intramuscular Tenosynovial Giant Cell Tumor, Diffuse-Type. ( 26755356 )	Lee Y.J....Kim C.H.	2016
19	Diffuse Type Tenosynovial Giant Cell Tumor of the Ankle. ( 26996490 )	Zhao J.J....Xiao K.	2016
20	Malignant tenosynovial giant cell tumor with CDKN2A/B genomic alteration: a histological, immunohistochemical, and molecular study. ( 27989786 )	Alexiev B.A....Yang G.Y.	2016
21	Tenosynovial giant cell tumor arising from the posterior cruciate ligament: a case report and literature review. ( 26261570 )	Xu Z....Jiang Q.	2015
22	Fine Needle Aspiration Cytology of Chondroid Tenosynovial Giant Cell Tumor of the Hand. ( 26266013 )	Abdou A.G....Youssef Asaad N.	2015
23	Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. ( 26222558 )	Tap W.D....Bollag G.	2015
24	Tenosynovial Giant Cell Tumor, Diffuse Type/Pigmented Villonodular Synovitis in a Pars Defect: A Case Report. ( 26067150 )	Kimura T....Sairyo K.	2015
25	Arthroscopic Resection of a Tenosynovial Giant Cell Tumor in the Wrist: A Case Report. ( 26496348 )	Lee Y.K....Lee M.	2015
26	Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature. ( 25861547 )	Richman D.M....Howard S.A.	2015
27	Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. ( 26337311 )	Sayed W....M'Barek M.	2015
28	Novel CSF1-S100A10 fusion gene and CSF1 transcript identified by RNA sequencing in tenosynovial giant cell tumors. ( 24604026 )	Panagopoulos I....Heim S.	2014
29	Tenosynovial Giant Cell Tumor of Diffuse Type Mimicking Bony Metastasis Detected on F-18 FDG PET/CT. ( 25177381 )	Chang K.J....Lim S.M.	2014
30	Primary diffuse-type tenosynovial giant cell tumor of the spine: a report of 3 cases and systemic review of the literature. ( 25269059 )	Wang K....Liu X.	2014
31	A tenosynovial giant cell tumor arising from femoral attachment of the anterior cruciate ligament. ( 24900909 )	Lee J.H....Wang S.I.	2014
32	Hepatoid tenosynovial giant cell tumor - A rare morphologic variant case report. ( 25023880 )	Yoshimoto T....Machinami R.	2014
33	Diffuse-type tenosynovial giant cell tumor with t(1;17)(p13;p13) and trisomy 5. ( 25189912 )	Nishio J....Naito M.	2014
34	Intramuscular diffuse-type tenosynovial giant cell tumor of the deltoid muscle in a child. ( 24676801 )	Yun S.J....Park S.Y.	2014
35	Tenosynovial giant cell tumor presenting as a parotid gland mass: Expanding the differential diagnosis of giant cell-rich lesions in salivary glands. ( 25745294 )	Guo L....Salih Z.T.	2014
36	Multiple metastases from histologically benign intraarticular diffuse-type tenosynovial giant cell tumor: a case report. ( 25130396 )	Asano N....Kawai A.	2014
37	Recurrent temporal bone tenosynovial giant cell tumor with chondroid metaplasia: the use of imaging to assess recurrence. ( 24571839 )	Pina S....Som P.M.	2014
38	Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. ( 23430345 )	Sikaria S....Mita M.	2013
39	Tenosynovial giant cell tumor arising on the scapular region. ( 24403889 )	Fukuda A....Kawana S.	2013
40	Tenosynovial giant cell tumor in an unusual localization. ( 23619549 )	Atik E....Tuna B.	2013
41	Chondroid tenosynovial giant cell tumor of the temporal bone. ( 23303171 )	Fisher M....McKinnon B.	2013
42	Navigation-guided resection for a tenosynovial giant cell tumor involving the temporomandibular joint and skull base. ( 22421861 )	He D....Ye M.	2012
43	Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. ( 22784912 )	Camillieri G....Calvisi V.	2012
44	Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. ( 21823110 )	Cassier P.A....Blay J.Y.	2012
45	Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. ( 22281719 )	Griffin A.M....O'Sullivan B.	2012
46	Tenosynovial giant cell tumor in the cervico-thoracic junction. ( 23208911 )	Okutan O....Beskonakli E.	2012
47	Tenosynovial giant cell tumor: case report and review. ( 22849738 )	Lucas D.R.	2012
48	Bilateral tenosynovial giant cell tumor of the knee accompanied by chronic ACL tear. ( 21590297 )	Cho H.J....Lee D.H.	2012
49	Malignant diffuse-type tenosynovial giant cell tumor of the buttock. ( 22827766 )	Kondo R....Yano H.	2012
50	Chondroid tenosynovial giant cell tumor: a clinicopathological and immunohistochemical analysis of 5 new cases. ( 21087985 )	Hoch B.L....Smalberger G.J.	2011

Sources

Genes for Tenosynovial Giant Cell Tumor

Genes related to Tenosynovial Giant Cell Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CSF1	Colony Stimulating Factor 1	Protein Coding	24.69	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	17.26	GeneCards inferred via : Publications (show sections)
3	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	17.26	GeneCards inferred via : Publications (show sections)
4	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	16.22	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	PGM1	Phosphoglucomutase 1	Protein Coding	15.56	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	CLU	Clusterin	Protein Coding	15.5	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	COL6A3	Collagen Type VI Alpha 3 Chain	Protein Coding	15.44	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	SERPINA3	Serpin Family A Member 3	Protein Coding	15.39	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

Sources

Variations for Tenosynovial Giant Cell Tumor

Sources

Expression for Tenosynovial Giant Cell Tumor

Search GEO for disease gene expression data for Tenosynovial Giant Cell Tumor.

Sources

Pathways for Tenosynovial Giant Cell Tumor

Pathways related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.3	CSF1 CSF1R
2	Validated targets of C-MYC transcriptional repression ¹	11.19	CDKN2B CLU
3	Macrophage Differentiation and Growth Inhibition by METS ⁶⁴ Show member pathways DNA Methylation and Transcriptional Repression ⁶⁴	11.08	CSF1 CSF1R
4	Signaling events mediated by PTP1B ¹	11.02	CSF1 CSF1R
5	Differentiation Pathway ¹	10.94	CSF1 CSF1R
6	Integrins in angiogenesis ¹	10.82	CSF1 CSF1R
7	Signaling events mediated by TCPTP ¹ Show member pathways MET activates PI3K/AKT signaling ⁶⁶	10.58	CSF1 CSF1R
8	Oncogene Induced Senescence ⁶⁶	10.13	CDKN2A CDKN2B

Sources

GO Terms for Tenosynovial Giant Cell Tumor

Cellular components related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:0031093	8.96	CLU SERPINA3
2	CSF1-CSF1R complex	GO:1990682	8.62	CSF1 CSF1R

Biological processes related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell proliferation	GO:0008285	9.63	CDKN2A CDKN2B CSF1R
2	inflammatory response	GO:0006954	9.58	CSF1 CSF1R SERPINA3
3	positive regulation of gene expression	GO:0010628	9.54	CDKN2A CLU CSF1
4	hemopoiesis	GO:0030097	9.43	CSF1 CSF1R
5	osteoclast differentiation	GO:0030316	9.32	CSF1 CSF1R
6	negative regulation of phosphorylation	GO:0042326	9.26	CDKN2A CDKN2B
7	macrophage differentiation	GO:0030225	9.16	CSF1 CSF1R
8	negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle	GO:0031658	8.96	CDKN2A CDKN2B
9	macrophage colony-stimulating factor signaling pathway	GO:0038145	8.62	CSF1 CSF1R

Molecular functions related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO:0004861	8.62	CDKN2A CDKN2B

Sources

Sources for Tenosynovial Giant Cell Tumor

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⁷¹ TGDB

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⁷⁶ Wikipedia