MCID: TNS001
MIFTS: 38

Tenosynovial Giant Cell Tumor

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Tenosynovial Giant Cell Tumor

MalaCards integrated aliases for Tenosynovial Giant Cell Tumor:

Name: Tenosynovial Giant Cell Tumor 12 15
Fibrous Histiocytoma of Tendon Sheath 12 73
Giant Cell Tumor of Tendon Sheath 12
Giant Cell Tumor of Tenosynovium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:314
ICD9CM 35 727.02
NCIt 50 C3402
UMLS 73 C1318543

Summaries for Tenosynovial Giant Cell Tumor

MalaCards based summary : Tenosynovial Giant Cell Tumor, also known as fibrous histiocytoma of tendon sheath, is related to pigmented villonodular synovitis and giant cell tumor. An important gene associated with Tenosynovial Giant Cell Tumor is CSF1 (Colony Stimulating Factor 1), and among its related pathways/superpathways are Dendritic Cells Developmental Lineage Pathway and Validated targets of C-MYC transcriptional repression. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, salivary gland and brain.

Wikipedia : 76 Giant-cell tumor of the tendon sheath, also known as giant-cell synovioma and localized nodular... more...

Related Diseases for Tenosynovial Giant Cell Tumor

Graphical network of the top 20 diseases related to Tenosynovial Giant Cell Tumor:



Diseases related to Tenosynovial Giant Cell Tumor

Symptoms & Phenotypes for Tenosynovial Giant Cell Tumor

Drugs & Therapeutics for Tenosynovial Giant Cell Tumor

Drugs for Tenosynovial Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1, Phase 2
2 Immunoglobulins Phase 1, Phase 2
3 Grapefruit Seed Extract Nutraceutical Phase 2
4
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
5
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
6
Warfarin Approved Phase 1 81-81-2 6691 54678486
7
Menadione Approved, Nutraceutical Phase 1 58-27-5 4055
8
Phytonadione Approved, Investigational, Nutraceutical Phase 1 84-80-0 4812 5284607
9 Albumin-Bound Paclitaxel Phase 1
10 Antimitotic Agents Phase 1
11 Antineoplastic Agents, Phytogenic Phase 1
12 Adjuvants, Anesthesia Phase 1
13 Anesthetics Phase 1
14 Anesthetics, General Phase 1
15 Anesthetics, Intravenous Phase 1
16 Anti-Anxiety Agents Phase 1
17 Anticoagulants Phase 1
18 Antifibrinolytic Agents Phase 1
19 Central Nervous System Depressants Phase 1
20 Coagulants Phase 1
21 GABA Agents Phase 1
22 GABA Modulators Phase 1
23 Hemostatics Phase 1
24 Hypnotics and Sedatives Phase 1
25 Micronutrients Phase 1
26 Neurotransmitter Agents Phase 1
27 Psychotropic Drugs Phase 1
28 Trace Elements Phase 1
29 Tranquilizing Agents Phase 1
30 Vitamins Phase 1
31 Menaquinone Nutraceutical Phase 1
32 naphthoquinone Nutraceutical Phase 1
33 Vitamin K Nutraceutical Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 Pexidartinib;Placebo
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
3 Study of Cabiralizumab in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Recruiting NCT02471716 Phase 1, Phase 2
4 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
5 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) Active, not recruiting NCT01643850 Phase 2 MCS110;Placebo;MCS110;Placebo
6 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Completed NCT01494688 Phase 1 Paclitaxel;RO5509554
7 Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics) Recruiting NCT03291288 Phase 1 Tolbutamide;Midazolam;Pexidartinib
8 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Terminated NCT02673736 Phase 1 PLX73086
9 Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors Terminated NCT01804530 Phase 1 PLX7486 TsOH
10 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088
11 Evaluation of the Effectiveness of Surgical Treatment of Villo-nodular Synovitis of the Hip in Children Recruiting NCT03507933

Search NIH Clinical Center for Tenosynovial Giant Cell Tumor

Genetic Tests for Tenosynovial Giant Cell Tumor

Anatomical Context for Tenosynovial Giant Cell Tumor

MalaCards organs/tissues related to Tenosynovial Giant Cell Tumor:

41
Bone, Salivary Gland, Brain, Thyroid

Publications for Tenosynovial Giant Cell Tumor

Articles related to Tenosynovial Giant Cell Tumor:

(show top 50) (show all 86)
# Title Authors Year
1
Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. ( 29637236 )
2018
2
Extra-articular tenosynovial giant cell tumor of diffuse type in the temporal area with brain parenchymal invasion: a case report. ( 29334779 )
2018
3
Successful treatment of a diffuse type tenosynovial giant cell tumor in the thoracic spine mimicking spinal metastasis by frozen recapping laminoplasty in a patient with thyroid cancer. ( 29663145 )
2018
4
Multifocal tenosynovial giant cell tumors in a child with Noonan syndrome. ( 27878339 )
2017
5
Extra-articular diffuse-type tenosynovial giant cell tumor with benign histological features resulting in fatal pulmonary metastases. ( 28219303 )
2017
6
Chondroid Tenosynovial Giant Cell Tumor of the Temporomandibular Joint: A Rare Case Report. ( 29215692 )
2017
7
Imaging features for diffuse-type tenosynovial giant cell tumor of the temporomandibular joint: A case report. ( 28658169 )
2017
8
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
9
Tenosynovial Giant Cell Tumor: Incidence, Prevalence, Patient Characteristics, and Recurrence. A Registry-based Cohort Study in Denmark. ( 28765257 )
2017
10
Tenosynovial Giant Cell Tumor in the Midfoot Treated With Femoral Head Allograft Reconstruction. ( 28864387 )
2017
11
Pitfalls in the cytological diagnosis of tenosynovial giant cell tumor: An illustration of eight discordant cases. ( 28941190 )
2017
12
Prognosis of Advanced Tenosynovial Giant Cell Tumor of the Knee Diagnosed During Total Knee Arthroplasty. ( 28161138 )
2017
13
Fine needle aspiration cytology diagnosis of metastatic malignant diffuse type tenosynovial giant cell tumor. ( 28701836 )
2017
14
Tenosynovial Giant Cell Tumor in the Dermis of the External Auditory Meatus. ( 27072732 )
2016
15
Coexisting sarcoidal granulomatous inflammation and diffuse tenosynovial giant cell tumor of the knee after a total knee replacement: a case report. ( 27717976 )
2016
16
Pediatric Intra-Articular Localized Tenosynovial Giant Cell Tumor Presenting as an Acutely Irritable Hip: A Case Report. ( 29252637 )
2016
17
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. ( 26820289 )
2016
18
Intramuscular Tenosynovial Giant Cell Tumor, Diffuse-Type. ( 26755356 )
2016
19
Diffuse Type Tenosynovial Giant Cell Tumor of the Ankle. ( 26996490 )
2016
20
Malignant tenosynovial giant cell tumor with CDKN2A/B genomic alteration: a histological, immunohistochemical, and molecular study. ( 27989786 )
2016
21
Tenosynovial giant cell tumor arising from the posterior cruciate ligament: a case report and literature review. ( 26261570 )
2015
22
Fine Needle Aspiration Cytology of Chondroid Tenosynovial Giant Cell Tumor of the Hand. ( 26266013 )
2015
23
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. ( 26222558 )
2015
24
Tenosynovial Giant Cell Tumor, Diffuse Type/Pigmented Villonodular Synovitis in a Pars Defect: A Case Report. ( 26067150 )
2015
25
Arthroscopic Resection of a Tenosynovial Giant Cell Tumor in the Wrist: A Case Report. ( 26496348 )
2015
26
Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature. ( 25861547 )
2015
27
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. ( 26337311 )
2015
28
Novel CSF1-S100A10 fusion gene and CSF1 transcript identified by RNA sequencing in tenosynovial giant cell tumors. ( 24604026 )
2014
29
Tenosynovial Giant Cell Tumor of Diffuse Type Mimicking Bony Metastasis Detected on F-18 FDG PET/CT. ( 25177381 )
2014
30
Primary diffuse-type tenosynovial giant cell tumor of the spine: a report of 3 cases and systemic review of the literature. ( 25269059 )
2014
31
A tenosynovial giant cell tumor arising from femoral attachment of the anterior cruciate ligament. ( 24900909 )
2014
32
Hepatoid tenosynovial giant cell tumor - A rare morphologic variant case report. ( 25023880 )
2014
33
Diffuse-type tenosynovial giant cell tumor with t(1;17)(p13;p13) and trisomy 5. ( 25189912 )
2014
34
Intramuscular diffuse-type tenosynovial giant cell tumor of the deltoid muscle in a child. ( 24676801 )
2014
35
Tenosynovial giant cell tumor presenting as a parotid gland mass: Expanding the differential diagnosis of giant cell-rich lesions in salivary glands. ( 25745294 )
2014
36
Multiple metastases from histologically benign intraarticular diffuse-type tenosynovial giant cell tumor: a case report. ( 25130396 )
2014
37
Recurrent temporal bone tenosynovial giant cell tumor with chondroid metaplasia: the use of imaging to assess recurrence. ( 24571839 )
2014
38
Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. ( 23430345 )
2013
39
Tenosynovial giant cell tumor arising on the scapular region. ( 24403889 )
2013
40
Tenosynovial giant cell tumor in an unusual localization. ( 23619549 )
2013
41
Chondroid tenosynovial giant cell tumor of the temporal bone. ( 23303171 )
2013
42
Navigation-guided resection for a tenosynovial giant cell tumor involving the temporomandibular joint and skull base. ( 22421861 )
2012
43
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. ( 22784912 )
2012
44
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. ( 21823110 )
2012
45
Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. ( 22281719 )
2012
46
Tenosynovial giant cell tumor in the cervico-thoracic junction. ( 23208911 )
2012
47
Tenosynovial giant cell tumor: case report and review. ( 22849738 )
2012
48
Bilateral tenosynovial giant cell tumor of the knee accompanied by chronic ACL tear. ( 21590297 )
2012
49
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. ( 22827766 )
2012
50
Chondroid tenosynovial giant cell tumor: a clinicopathological and immunohistochemical analysis of 5 new cases. ( 21087985 )
2011

Variations for Tenosynovial Giant Cell Tumor

Expression for Tenosynovial Giant Cell Tumor

Search GEO for disease gene expression data for Tenosynovial Giant Cell Tumor.

Pathways for Tenosynovial Giant Cell Tumor

GO Terms for Tenosynovial Giant Cell Tumor

Cellular components related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.96 CLU SERPINA3
2 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.63 CDKN2A CDKN2B CSF1R
2 inflammatory response GO:0006954 9.58 CSF1 CSF1R SERPINA3
3 positive regulation of gene expression GO:0010628 9.54 CDKN2A CLU CSF1
4 hemopoiesis GO:0030097 9.43 CSF1 CSF1R
5 osteoclast differentiation GO:0030316 9.32 CSF1 CSF1R
6 negative regulation of phosphorylation GO:0042326 9.26 CDKN2A CDKN2B
7 macrophage differentiation GO:0030225 9.16 CSF1 CSF1R
8 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 8.96 CDKN2A CDKN2B
9 macrophage colony-stimulating factor signaling pathway GO:0038145 8.62 CSF1 CSF1R

Molecular functions related to Tenosynovial Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN2A CDKN2B

Sources for Tenosynovial Giant Cell Tumor

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74 UMLS via Orphanet
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