MCID: TNS014
MIFTS: 36

Tenosynovitis

Categories: Bone diseases, Muscle diseases

Aliases & Classifications for Tenosynovitis

MalaCards integrated aliases for Tenosynovitis:

Name: Tenosynovitis 12 44 15 73
Inflammation of Tendon Sheath 12

Classifications:



External Ids:

Disease Ontology 12 DOID:970
MeSH 44 D013717
UMLS 73 C0039520

Summaries for Tenosynovitis

MalaCards based summary : Tenosynovitis, also known as inflammation of tendon sheath, is related to bursitis and calcific tendinitis. An important gene associated with Tenosynovitis is LHB (Luteinizing Hormone Beta Polypeptide), and among its related pathways/superpathways is Immune response IFN gamma signaling pathway. The drugs Methotrexate and Sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Tenosynovitis is the inflammation of the fluid-filled sheath (called the synovium) that surrounds a... more...

Related Diseases for Tenosynovitis

Diseases related to Tenosynovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 bursitis 30.8 CRP MRAP
2 calcific tendinitis 30.5 CRP LHB
3 juvenile rheumatoid arthritis 29.1 CRP TNFRSF1B
4 vasculitis 28.8 CRP TNFRSF1B
5 tendinitis 28.2 AKTIP CRP LHB MRAP SIK1
6 bicipital tenosynovitis 12.3
7 nodular tenosynovitis 12.1
8 tenosynovitis of foot and ankle 11.9
9 de quervain disease 11.7
10 overuse syndrome 11.2
11 tenosynovial giant cell tumor 11.2
12 repetitive motion disorders 11.2
13 pigmented villonodular synovitis 11.2
14 gonococcal synovitis 11.1
15 repetitive stress injuries 10.9
16 synovitis 10.8
17 aortitis 10.5 CRP MRAP
18 arthritis 10.4
19 pyuria 10.4 CRP MRAP
20 spinal disease 10.4 CRP MRAP
21 mesenteric lymphadenitis 10.4 CRP MRAP
22 rheumatoid arthritis 10.3
23 scleral disease 10.3 MRAP TNFRSF1B
24 pericoronitis 10.3 CRP TNFRSF1B
25 iritis 10.3 MRAP TNFRSF1B
26 skeletal tuberculosis 10.2 CRP MRAP
27 pustulosis of palm and sole 10.2 MRAP TNFRSF1B
28 mycobacterium marinum 10.2
29 orbital plasma cell granuloma 10.2 MRAP TNFRSF1B
30 chronic orbital inflammation 10.2 MRAP TNFRSF1B
31 acute salpingitis 10.2 MRAP TNFRSF1B
32 anterior scleritis 10.2 MRAP TNFRSF1B
33 granulomatous hepatitis 10.1 CRP TNFRSF1B
34 panuveitis 10.1 MRAP TNFRSF1B
35 carpal tunnel syndrome 10.1
36 mononeuropathy of the median nerve, mild 10.1
37 mycobacterium kansasii 10.1
38 exanthem 10.1 CRP TNFRSF1B
39 hypersensitivity reaction type iv disease 10.0 MRAP TNFRSF1B
40 giant cell tumor 10.0
41 primary bacterial infectious disease 10.0 CRP TNFRSF1B
42 osteomyelitis 10.0
43 epicondylitis 10.0
44 iron deficiency anemia 9.9 CRP SLC40A1
45 miliary tuberculosis 9.9
46 spondylitis 9.9 CRP TNFRSF1B
47 palindromic rheumatism 9.9 CRP MRAP TNFRSF1B
48 spondyloarthropathy 1 9.8 CRP MRAP TNFRSF1B
49 bone inflammation disease 9.8 CRP MRAP TNFRSF1B
50 intestinal disease 9.8 CRP MRAP TNFRSF1B

Graphical network of the top 20 diseases related to Tenosynovitis:



Diseases related to Tenosynovitis

Symptoms & Phenotypes for Tenosynovitis

GenomeRNAi Phenotypes related to Tenosynovitis according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.53 CRP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.53 CCL7
3 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.53 CRP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.53 CCL7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.53 CRP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.53 LHB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.53 CCL7
8 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.53 CCL7
9 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.53 LHB
10 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.53 CCL7
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.53 CCL7 CRP LHB
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.53 CRP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.53 CCL7
14 Increased shRNA abundance (Z-score > 2) GR00366-A-97 9.53 LHB

Drugs & Therapeutics for Tenosynovitis

Drugs for Tenosynovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
2
Sulfasalazine Approved Phase 4,Not Applicable 599-79-1 5353980 5359476
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
5
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
6
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 143 6006
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
8 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
9 Analgesics Phase 4,Phase 2,Phase 3
10 glucocorticoids Phase 4,Phase 3
11 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
12 Hormone Antagonists Phase 4,Phase 3
13 Hormones Phase 4,Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
15 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3
17 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
18 Antineoplastic Agents, Hormonal Phase 4,Phase 3
19 beta-endorphin Phase 4
20 Betamethasone Valerate Phase 4 2152-44-5
21 Respiratory System Agents Phase 4
22 Adrenocorticotropic Hormone Phase 4
23 Gastrointestinal Agents Phase 4,Phase 3
24 Anti-Asthmatic Agents Phase 4
25 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2
26 Melanocyte-Stimulating Hormones Phase 4
27 Betamethasone benzoate Phase 4
28 Betamethasone sodium phosphate Phase 4
29 Betamethasone-17,21-dipropionate Phase 4
30 Folic Acid Antagonists Phase 4,Phase 2
31 Dermatologic Agents Phase 4,Phase 2
32 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
33 Vitamin B Complex Phase 4,Phase 2
34 Anti-Infective Agents Phase 4
35 Antimetabolites Phase 4,Phase 2
36 Antimetabolites, Antineoplastic Phase 4,Phase 2
37 Folate Nutraceutical Phase 4,Phase 2
38 Vitamin B9 Nutraceutical Phase 4,Phase 2
39
Diclofenac Approved, Vet_approved Phase 2, Phase 3,Not Applicable 15307-86-5 3033
40
Lidocaine Approved, Vet_approved Phase 3,Not Applicable 137-58-6 3676
41
Abatacept Approved Phase 3,Phase 1,Phase 2 332348-12-6 10237
42
Ketorolac Approved Phase 3 74103-06-3, 66635-83-4 3826
43
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
44
Etoricoxib Approved, Investigational Phase 3 202409-33-4 123619
45 Cyclooxygenase Inhibitors Phase 2, Phase 3,Phase 3
46 Dexamethasone acetate Phase 3 1177-87-3
47
protease inhibitors Phase 3
48 HIV Protease Inhibitors Phase 3
49 Dexamethasone 21-phosphate Phase 3
50 Antiemetics Phase 3

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4 prednisone
2 Aiming for Remission in Rheumatoid Arthritis (RA) - the ARCTIC Trial Completed NCT01205854 Phase 4
3 Ultrasound-guided Injection for DeQuervain's Recruiting NCT02038634 Phase 4 Betamethasone
4 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis Recruiting NCT02765074 Phase 4 subcutaneous tocilizumab
5 Efficacy, Radiographic and Laboratory Changes in Refractory Rheumatoid Arthritis Patients Treated With H.P. Acthar Gel Recruiting NCT03082573 Phase 4 H.P. Acthar gel
6 Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging Study Terminated NCT01659242 Phase 4 Methotrexate plus sulfasalazine;Leflunomide
7 Diclofenac Patch for Treatment of Mild to Moderate Tendonitis or Bursitis Completed NCT00640939 Phase 2, Phase 3 diclofenac sodium;Matching Placebo
8 Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders Recruiting NCT02266433 Phase 3 Ketorolac;Dexamethasone
9 Abatacept Reversing Subclinical Inflammation as Measured by MRI in ACPA Positive Arthralgia Recruiting NCT02778906 Phase 3 Abatacept;Placebo
10 Corticosteroid vs. Amniotic Fluid Injections in Patients With Trigger Finger Enrolling by invitation NCT03583151 Phase 3
11 Etoricoxib in Acute Soft Tissue Rheumatism Affecting the Shoulder Terminated NCT00876317 Phase 3 Etoricoxib 60 mg;Etoricoxib 90 mg
12 Tocilizumab Effect iN pOlymyalgia Rheumatica Completed NCT01713842 Phase 2 TCZ
13 Abatacept for SLE Arthritis (IM101-330) Recruiting NCT02429934 Phase 1, Phase 2 abatacept;Placebo
14 Study of BOS161721 in Systemic Lupus Erythematosus (SLE) Patients on a Background of Limited Standard of Care Recruiting NCT03371251 Phase 1, Phase 2 BOS161721;Placebo
15 A Trial Investigating the Mechanism of Action of NNC0109-0012 (Anti-IL-20 mAb) Through Synovial Biopsies in Subjects With Rheumatoid Arthritis and an Inadequate Response to Methotrexate Withdrawn NCT02097264 Phase 2 NNC0109-0012;Adalimumab;placebo
16 Study Comparing One Versus Two Cortisone Injections for Trigger Finger Unknown status NCT00951236 Not Applicable One cortisone injection;Two cortisone Injections
17 Treatment of Trigger Finger With Steroid Injection Versus Steroid Injection and Splinting Unknown status NCT01886157 Not Applicable
18 Treatment of Insertional Achilles Tendinopathy by Hyaluronic Acid Injection Unknown status NCT02368561 Early Phase 1 Injection of Hyaluronic Acid -" SYNVISC" (hylan G-F 20)
19 A Clinical Trial of Splinting for DeQuervain's Tenosynovitis Completed NCT00438191
20 A Case Control Study to Define Clinical, Immunologic and Radiographic Features of the Aromatase Inhibitor Arthralgia Syndrome Completed NCT00890058
21 Effect of Immobilization of the Metacarpophalangeal Joint in Thumb Osteoarthritis Completed NCT02780999 Not Applicable
22 Comparison of the Clinical Examination and the Joint Ultrasonography in Lupus Patients Completed NCT02922114 Not Applicable
23 Ultrasound Findings of Finger, Wrist and Knee Joints in Mucopolysaccharidosis Completed NCT02067650
24 Biomarkers of Remission in Rheumatoid Arthritis (BioRRA) Completed NCT02219347 Not Applicable DMARD cessation
25 The Treatment of Purulent Flexor Tenosynovitis Recruiting NCT02320929 Not Applicable
26 Sinew Acupuncture for de Quervain's Tenosynovitis Recruiting NCT03472443 Not Applicable
27 Effectiveness of Astym Treatment For de Quervain's Tenosynovitis Recruiting NCT02442622 Not Applicable
28 Disparity Between Ultrasound- and Clinical Findings in Psoriatic Arthritis in Remission Recruiting NCT03396679
29 Effects of Hypertonic Dextrose Water Injection for Supraspinatus Tendinosis Patients Recruiting NCT03000205 Not Applicable
30 Prospective Study of Patients With Rheumatoid Arthritis After the Age of 65 Recruiting NCT02686320
31 The Natural History of Congenital Trigger Thumbs Active, not recruiting NCT01424995
32 A Prospective Study Comparing Suture Anchor and Soft Tissue Pectoralis Major Tendon Techniques for Biceps Tenodesis Not yet recruiting NCT03529162 Not Applicable
33 Prediction of Erosive Disease in Early Rheumatoid Arthritis (RA) by Ultrasound and Cartilage Biodegradation Markers Not yet recruiting NCT02464384 Not Applicable
34 Rheumatoid Arthritis Response to Methotrexate Not yet recruiting NCT03535519 Methotrexate
35 Musculoskeletal Pathologies of the Upper Extremity in Surgical Device Mechanics Not yet recruiting NCT03014128

Search NIH Clinical Center for Tenosynovitis

Cochrane evidence based reviews: tenosynovitis

Genetic Tests for Tenosynovitis

Anatomical Context for Tenosynovitis

MalaCards organs/tissues related to Tenosynovitis:

41
Bone, Liver, Skin, Kidney

Publications for Tenosynovitis

Articles related to Tenosynovitis:

(show top 50) (show all 229)
# Title Authors Year
1
Cost-Effective Management of Stenosing Tenosynovitis. ( 29891265 )
2018
2
Reply to "MRI in de Quervain Tenosynovitis: Is Making the Diagnosis Sufficient?" ( 29469623 )
2018
3
MRI in De Quervain Tenosynovitis: Is Making the Diagnosis Sufficient? ( 29469625 )
2018
4
Tenosynovitis caused by Mycobacterium malmoense in two kidney transplant recipients and review of the literature. ( 29125666 )
2018
5
Nodular Tenosynovitis of the Temporomandibular Joint: An Entity Not Yet Described. ( 29762327 )
2018
6
A Rare Cause of Pyogenic Flexor Tenosynovitis: Nocardia nova. ( 29352602 )
2018
7
Lipoma arborescens-a rare cause of bilateral ankle tenosynovitis. ( 29351664 )
2018
8
Gonococcal Tenosynovitis Diagnosed with the Aid of Emergency Department Bedside Ultrasound. ( 29685466 )
2018
9
Chronic Tenosynovitis due to <i>Mycobacteria kansasii</i> in an Immunocompetent Host. ( 29850302 )
2018
10
Usefulness of ultrasound for the diagnosis of pyogenic flexor tenosynovitis: A prospective single-center study of 57 cases. ( 29396150 )
2018
11
Results of surgical treatment of De Quervain's tenosynovitis: 80 cases with a mean follow-up of 9.5 years. ( 29909297 )
2018
12
Ultrasound for the diagnosis of pyogenic flexor tenosynovitis. ( 29759904 )
2018
13
Ultrasonography for diagnosis, monitoring and treatment of tenosynovitis in patients with rheumatoid arthritis. ( 29510818 )
2018
14
Tuberculous tenosynovitis of the flexor tendons of the wrist: a case report. ( 29636100 )
2018
15
The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound: the STARTER study. ( 29886430 )
2018
16
Infectious flexor hand tenosynovitis: State of knowledge. A study of 120 cases. ( 29881224 )
2018
17
'Deep Koebner' phenomenon of the flexor tendon-associated accessory pulleys as a novel factor in tenosynovitis and dactylitis in psoriatic arthritis. ( 29511028 )
2018
18
The role of ultrasound-defined tenosynovitis and synovitis in the prediction of rheumatoid arthritis development. ( 29618136 )
2018
19
Tenosynovitis with Rice Body Formation Due to Mycobacterium Intracellulare Infection After Initiation of Infliximab Therapy. ( 29875354 )
2018
20
<i>Histoplasma</i> Tenosynovitis Revealed by Fungal Culture in a Patient Treated with Infliximab. ( 29419449 )
2018
21
Proximal linear extension of skin hypopigmentation after ultrasound-guided corticosteroid injection for de Quervain tenosynovitis: A Case Report. ( 29355747 )
2018
22
Kingella kingae hand and wrist tenosynovitis in young children. ( 29587602 )
2018
23
Idiopathic Peroneal Tenosynovitis Caused by a Previously Undiagnosed Auto-immune Condition. ( 29713574 )
2018
24
The Use of the OMERACT Ultrasound Tenosynovitis Scoring System in Multicenter Clinical Trials. ( 29247153 )
2018
25
Oyster-related tenosynovitis: a rare case of<i>Mycobacterium szulgai</i>in the immunocompromised. ( 29275385 )
2017
26
Polymicrobial pyogenic flexor tenosynovitis of the index finger and first ray resulting from autophagia. ( 28725123 )
2017
27
Level of agreement between three-dimensional volumetric ultrasound and real-time conventional ultrasound in the assessment of synovitis, tenosynovitis and erosions in rheumatoid arthritis patients. ( 27896420 )
2017
28
Tenosynovitis Evaluation Using Image Fusion and B-Flow - A Pilot Study on New Imaging Techniques in Rheumatoid Arthritis Patients. ( 28511227 )
2017
29
Posterior Tibial Tendon Tenosynovitis Diagnosed by Point-of-Care Ultrasound. ( 29849380 )
2017
30
Sporotrichal Tenosynovitis Diagnosed Helpfully by Musculoskeletal Ultrasonography. ( 28502945 )
2017
31
Tibialis Posterior Tenosynovitis: A Unique Musculoskeletal Manifestation of Gout. ( 28632507 )
2017
32
Flexor Hallucis Longus Tenosynovitis and First Metatarsophalangeal Synovitis After Penetrating Nail Prick Injury: Treated by Zone 3 Flexor Hallucis Longus Tendoscopy and Metatarsosesamoid Arthroscopy. ( 28580263 )
2017
33
5 Points on Pyogenic Flexor Tenosynovitis of the Hand. ( 28666046 )
2017
34
Tenosynovitis in rheumatoid arthritis patients on biologic treatment: involvement and sensitivity to change compared to joint inflammation. ( 28516887 )
2017
35
Shear wave elastography findings of de Quervain tenosynovitis. ( 28987667 )
2017
36
A Genetic Marker Associated with De Quervain's Tenosynovitis. ( 28985641 )
2017
37
Infectious tenosynovitis with bloodstream infection caused by Erysipelothrix rhusiopathiae, a case report on an occupational pathogen. ( 28056818 )
2017
38
Rice Bodies in Tuberculous Tenosynovitis of Wrist. ( 29102590 )
2017
39
Pyogenic Tenosynovitis in Infants: A Case Series. ( 28661965 )
2017
40
Non-tuberculous Mycobacterium or Fungus Induced Chronic Tenosynovitis with Rice Body of the Hand. ( 28774249 )
2017
41
Differentiation Between Pyogenic Flexor Tenosynovitis and Other Finger Infections. ( 28720000 )
2017
42
Effectiveness of Corticosteroid Injections for Treatment of de Quervain's Tenosynovitis. ( 28644946 )
2017
43
Dynamic Functional Assessment of Hand Motion Using an Animation Glove: The Effect of Stenosing Tenosynovitis. ( 28984481 )
2017
44
Tenosynovitis caused by Scedosporium apiospermum infection misdiagnosed as an Alternaria species: a case report. ( 28088169 )
2017
45
Cases of Early Infectious Flexor Tenosynovitis Treated Non-Surgically With Antibiotics, Immobilization, and Elevation. ( 29619351 )
2017
46
Closed Continuous Irrigation With Lidocaine and Immediate Mobilization for Treatment of Pyogenic Tenosynovitis. ( 28727585 )
2017
47
Successful Treatment of Protothecal Tenosynovitis in an Immunocompetent Patient using Amphotericin B Deoxycholate. ( 29299897 )
2017
48
Suppurative Flexor Tenosynovitis Secondary to Hematogenous Seeding. ( 28626496 )
2017
49
Subclinical synovitis and tenosynovitis by ultrasonography (US) 7 score in patients with rheumatoid arthritis treated with synthetic drugs, in clinical remission by DAS28. ( 29198500 )
2017
50
Tuberculous Tenosynovitis of the Wrist and the Hand: The 3 Anatomo- Clinical Forms Described by Kanavel (About 4 Cases). ( 29600215 )
2017

Variations for Tenosynovitis

Expression for Tenosynovitis

Search GEO for disease gene expression data for Tenosynovitis.

Pathways for Tenosynovitis

Pathways related to Tenosynovitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.81 CCL7 LHB TNFRSF1B

GO Terms for Tenosynovitis

Biological processes related to Tenosynovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 8.8 CCL7 CRP TNFRSF1B

Sources for Tenosynovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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