MCID: TRT001
MIFTS: 40

Teratocarcinoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Teratocarcinoma

MalaCards integrated aliases for Teratocarcinoma:

Name: Teratocarcinoma 12 55 44 15 73
Mixed Embryonal Carcinoma and Teratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3305
MeSH 44 D018243
NCIt 50 C3756
SNOMED-CT 68 67830002
UMLS 73 C0206664

Summaries for Teratocarcinoma

Disease Ontology : 12 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards based summary : Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to embryonal carcinoma and childhood teratocarcinoma of the testis. An important gene associated with Teratocarcinoma is MIR302A (MicroRNA 302a
The miR-302 cluster was potently expressed in undifferentiated NTera2D1 and P19 cells, but hardly in differentiated cells, such that miR-124a showed an opposite expression pattern to the miR-302 cluster.it is suggested that the miR-302 cluster and miR-124a may be useful molecular indicators in the assessment of degree of undifferentiation and/or differentiation in the course of neuronal differentiation.), and among its related pathways/superpathways are Developmental Biology and Pathways in cancer. Affiliated tissues include testis, testis germ and ovary, and related phenotypes are embryo and mortality/aging

Wikipedia : 76 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

Related Diseases for Teratocarcinoma

Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to Teratocarcinoma

Symptoms & Phenotypes for Teratocarcinoma

MGI Mouse Phenotypes related to Teratocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.96 ENPP2 FGF4 JUN LAMB1 NANOG NR6A1
2 mortality/aging MP:0010768 9.73 CRABP1 ENPP2 FGF4 JUN LAMB1 NANOG
3 limbs/digits/tail MP:0005371 9.63 CRABP1 FGF4 LAMB1 NR6A1 RARA RARB
4 normal MP:0002873 9.32 GSR JUN POU5F1 RARA RARB SEPT3

Drugs & Therapeutics for Teratocarcinoma

Search Clinical Trials , NIH Clinical Center for Teratocarcinoma

Cochrane evidence based reviews: teratocarcinoma

Genetic Tests for Teratocarcinoma

Anatomical Context for Teratocarcinoma

MalaCards organs/tissues related to Teratocarcinoma:

41
Testis, Testis Germ, Ovary, Bone, Lung, Brain, Colon

Publications for Teratocarcinoma

Articles related to Teratocarcinoma:

(show top 50) (show all 520)
# Title Authors Year
1
Biocompatible Gold Nanoparticles Ameliorate Retinoic Acid-Induced Cell Death and Induce Differentiation in F9 Teratocarcinoma Stem Cells. ( 29865197 )
2018
2
Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells. ( 29207191 )
2018
3
New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells. ( 29439916 )
2018
4
Ovarian Teratocarcinoma in an Emu (Dromaius novaehollandiae): Histopathological and Immunohistochemical Characterization. ( 29599003 )
2018
5
Correlative Studies Unravelling the Possible Mechanism of Cell Death in Tideglusib-Treated Human Ovarian Teratocarcinoma-Derived PA-1 Cells. ( 29431064 )
2017
6
Frizzled gene expression and negative regulation of canonical WNT-I^-catenin signaling in mouse F9 teratocarcinoma cells. ( 28177772 )
2017
7
Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGFI^ Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Acid. ( 28798778 )
2017
8
Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy. ( 29066898 )
2017
9
Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin. ( 27116544 )
2016
10
Vitamin D3 stimulates embryonic stem cells but inhibits migration and growth of ovarian cancer and teratocarcinoma cell lines. ( 27091127 )
2016
11
Lysine methylation represses p53 activity in teratocarcinoma cancer cells. ( 27535933 )
2016
12
Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo. ( 27185102 )
2016
13
The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1. ( 25761220 )
2015
14
Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1. ( 25746218 )
2015
15
Pleuritis caused by Acremonium strictum in a patient with metastatic testicular teratocarcinoma. ( 26042869 )
2015
16
Nicotinamide induces apoptosis of F9 mouse teratocarcinoma stem cells by downregulation of SATB1 expression. ( 25596087 )
2015
17
Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/I^-catenin signaling. ( 25138740 )
2014
18
Ligand-independent androgen receptors promote ovarian teratocarcinoma cell growth by stimulating self-renewal of cancer stem/progenitor cells. ( 24793306 )
2014
19
MicroRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonic carcinoma P19 cells. ( 23007514 )
2013
20
Extracellular syntaxin4 triggers the differentiation program in teratocarcinoma F9 cells that impacts cell adhesion properties. ( 23884628 )
2013
21
MicroRNA-21 promotes the ovarian teratocarcinoma PA1 cell line by sustaining cancer stem/progenitor populations in vitro. ( 23890123 )
2013
22
Teratocarcinoma in a non seminomatous, mixed germ cell tumour of the testis-a rare entity. ( 23998086 )
2013
23
KSRP silencing favors neural differentiation of P19 teratocarcinoma cells. ( 23462617 )
2013
24
Development of experimental tumors formed by mouse and human embryonic stem and teratocarcinoma cells after subcutaneous and intraperitoneal transplantations into immunodeficient and immunocompetent mice. ( 23051679 )
2013
25
Murine teratocarcinoma-derived neuronal cultures. ( 23975819 )
2013
26
Presacral teratocarcinoma presenting as anal fistula and rectal adenocarcinoma: a unique case presentation and literature review. ( 22611366 )
2012
27
Teratocarcinoma formation in embryonic stem cell-derived neural progenitor hippocampal transplants. ( 22776287 )
2012
28
Primary CNS teratocarcinoma. ( 22363315 )
2012
29
Wnt/I^-catenin signaling pathway upregulates c-Myc expression to promote cell proliferation of P19 teratocarcinoma cells. ( 22976998 )
2012
30
Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea. ( 22100652 )
2011
31
A spontaneous teratocarcinoma in the testis of a swiss albino mouse. ( 21270422 )
2011
32
Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect. ( 19853938 )
2011
33
Unusual autopsy finding in a case of metastatic teratocarcinoma. ( 21109467 )
2011
34
Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell. ( 19943082 )
2011
35
A teratocarcinoma-like human embryonic stem cell (hESC) line and four hESC lines reveal potentially oncogenic genomic changes. ( 20428235 )
2010
36
Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. ( 20385969 )
2010
37
Effects of insulin-like growth factor binding protein 7 on apoptosis in human teratocarcinoma cells in vitro. ( 20393014 )
2010
38
Angiogenesis and vascular network of teratocarcinoma from embryonic stem cell transplant into seminiferous tubules. ( 19513074 )
2009
39
Suppression of teratocarcinoma growth by soluble TRAIL gene expression driven by the progression-elevated gene-3 promoter. ( 19823015 )
2009
40
Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells. ( 18237746 )
2008
41
Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm. ( 17993262 )
2008
42
Testicular teratocarcinoma associated with testicular microlithiasis. ( 17464445 )
2008
43
Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke. ( 18514379 )
2008
44
Mediastinal teratocarcinoma as initial manifestation of asymptomatic HIV infection: a case report. ( 18663349 )
2008
45
Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells. ( 18164278 )
2008
46
Primary mediastinal giant teratocarcinoma. ( 18626155 )
2008
47
Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. ( 17875646 )
2007
48
Cervical mature teratoma 17 years after initial treatment of testicular teratocarcinoma: report of a late relapse. ( 17201931 )
2007
49
ER stress induces the expression of Jpk, which inhibits cell cycle progression in F9 teratocarcinoma cell. ( 17404020 )
2007
50
Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. ( 17716626 )
2007

Variations for Teratocarcinoma

Expression for Teratocarcinoma

Search GEO for disease gene expression data for Teratocarcinoma.

Pathways for Teratocarcinoma

GO Terms for Teratocarcinoma

Biological processes related to Teratocarcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.96 FGF4 JUN RARA RARB TDGF1
2 positive regulation of cell proliferation GO:0008284 9.95 FGF4 JUN RARA RARB TDGF1
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.87 FGF4 JUN NANOG NR6A1 POU5F1 RARA
4 heart development GO:0007507 9.83 RARA RARB TDGF1 TDGF1P3
5 liver development GO:0001889 9.71 JUN RARA RARB
6 somatic stem cell population maintenance GO:0035019 9.63 NANOG POU5F1 TDGF1
7 steroid hormone mediated signaling pathway GO:0043401 9.61 NR6A1 RARA RARB
8 retinoic acid receptor signaling pathway GO:0048384 9.58 RARA RARB
9 regulation of myelination GO:0031641 9.57 RARA RARB
10 epithelium development GO:0060429 9.51 RARA RARB
11 nodal signaling pathway GO:0038092 9.49 TDGF1 TDGF1P3
12 negative regulation of cartilage development GO:0061037 9.48 RARA RARB
13 growth plate cartilage development GO:0003417 9.4 RARA RARB
14 gland development GO:0048732 9.37 RARA RARB
15 ventricular cardiac muscle cell differentiation GO:0055012 9.26 RARA RARB
16 endodermal cell fate specification GO:0001714 9.16 NANOG POU5F1
17 chondroblast differentiation GO:0060591 8.96 FGF4 RARA
18 glandular epithelial cell development GO:0002068 8.62 RARA RARB

Molecular functions related to Teratocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.8 JUN NANOG NR6A1 POU5F1 RARA RARB
2 transcription factor binding GO:0008134 9.76 ENPP2 JUN RARA RARB
3 transcription regulatory region sequence-specific DNA binding GO:0000976 9.58 POU5F1 RARA RARB
4 steroid hormone receptor activity GO:0003707 9.54 NR6A1 RARA RARB
5 transcription factor activity, direct ligand regulated sequence-specific DNA binding GO:0098531 9.43 RARA RARB
6 retinoic acid receptor activity GO:0003708 9.26 RARA RARB
7 nodal binding GO:0038100 9.16 TDGF1 TDGF1P3
8 nuclear receptor activity GO:0004879 9.13 NR6A1 RARA RARB
9 activin receptor binding GO:0070697 8.62 TDGF1 TDGF1P3

Sources for Teratocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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