MCID: TRT001
MIFTS: 41

Teratocarcinoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Teratocarcinoma

MalaCards integrated aliases for Teratocarcinoma:

Name: Teratocarcinoma 12 56 45 15 74
Mixed Embryonal Carcinoma and Teratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3305
MeSH 45 D018243
NCIt 51 C3756
SNOMED-CT 69 67830002
UMLS 74 C0206664

Summaries for Teratocarcinoma

Disease Ontology : 12 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards based summary : Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to embryonal carcinoma and childhood teratocarcinoma of the testis. An important gene associated with Teratocarcinoma is MIR302A (MicroRNA 302a), and among its related pathways/superpathways are Developmental Biology and Pathways in cancer. Affiliated tissues include testis, ovary and brain, and related phenotypes are embryo and limbs/digits/tail

Wikipedia : 77 A germ-cell tumor (GCT) is a neoplasm derived from germ cells. Germ-cell tumors can be cancerous or... more...

Related Diseases for Teratocarcinoma

Diseases related to Teratocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 embryonal carcinoma 29.1 CRABP1 FGF4 JUN NR6A1 POU5F1 RARA
2 childhood teratocarcinoma of the testis 12.2
3 leukemia 10.2
4 teratoma 10.2
5 ovarian embryonal carcinoma 10.1 NANOG POU5F1
6 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 10.1 NANOG POU5F1
7 venous hemangioma 10.1 NANOG POU5F1
8 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.0 RARA RARB
9 rheumatoid arthritis 10.0
10 insulin-like growth factor i 10.0
11 testicular microlithiasis 10.0
12 testicular cancer 10.0
13 seminoma 10.0
14 mature teratoma 10.0
15 embryonal testis carcinoma 10.0
16 cytomegalovirus infection 10.0
17 mixed germ cell cancer 10.0 CRABP1 POU5F1 TDGF1
18 alzheimer disease 9.9
19 hairy nose tip 9.9
20 systemic lupus erythematosus 9.9
21 ovarian cancer 9.9
22 pancreatic cancer 9.9
23 spermatogenic failure, x-linked, 1 9.9
24 adenine phosphoribosyltransferase deficiency 9.9
25 anal fistula 9.9
26 male infertility 9.9
27 meningocele 9.9
28 melanoma 9.9
29 rectum adenocarcinoma 9.9
30 adenocarcinoma 9.9
31 choriocarcinoma 9.9
32 infertility 9.9
33 human immunodeficiency virus infectious disease 9.9
34 hyperthyroidism 9.9
35 influenza 9.9
36 herpes simplex 9.9
37 in situ carcinoma 9.9
38 lupus erythematosus 9.9
39 stomatitis 9.9
40 germ cells tumors 9.9
41 splenomegaly 9.9
42 germ cell cancer 9.9 FGF4 NANOG POU5F1
43 phosphoglycerate dehydrogenase deficiency 9.9 NANOG POU5F1
44 acute promyelocytic leukemia 9.8 CRABP1 JUN RARA RARB

Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to Teratocarcinoma

Symptoms & Phenotypes for Teratocarcinoma

MGI Mouse Phenotypes related to Teratocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.85 ENPP2 FGF4 JUN LAMB1 NANOG NR6A1
2 limbs/digits/tail MP:0005371 9.43 CRABP1 FGF4 LAMB1 NR6A1 RARA RARB
3 normal MP:0002873 9.28 CRABP1 ENPP2 FGF4 GSR JUN POU5F1

Drugs & Therapeutics for Teratocarcinoma

Search Clinical Trials , NIH Clinical Center for Teratocarcinoma

Cochrane evidence based reviews: teratocarcinoma

Genetic Tests for Teratocarcinoma

Anatomical Context for Teratocarcinoma

MalaCards organs/tissues related to Teratocarcinoma:

42
Testis, Ovary, Brain, T Cells, Thymus, Colon, Pituitary

Publications for Teratocarcinoma

Articles related to Teratocarcinoma:

(show top 50) (show all 887)
# Title Authors Year
1
The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells. ( 30818388 )
2019
2
Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells. ( 29207191 )
2018
3
Biocompatible Gold Nanoparticles Ameliorate Retinoic Acid-Induced Cell Death and Induce Differentiation in F9 Teratocarcinoma Stem Cells. ( 29865197 )
2018
4
Ovarian Teratocarcinoma in an Emu (Dromaius novaehollandiae): Histopathological and Immunohistochemical Characterization. ( 29599003 )
2018
5
New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells. ( 29439916 )
2018
6
Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin. ( 27116544 )
2017
7
Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo. ( 27185102 )
2017
8
Frizzled gene expression and negative regulation of canonical WNT-β-catenin signaling in mouse F9 teratocarcinoma cells. ( 28177772 )
2017
9
Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGFβ Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Acid. ( 28798778 )
2017
10
Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy. ( 29066898 )
2017
11
Correlative Studies Unravelling the Possible Mechanism of Cell Death in Tideglusib-Treated Human Ovarian Teratocarcinoma-Derived PA-1 Cells. ( 29431064 )
2017
12
Vitamin D3 stimulates embryonic stem cells but inhibits migration and growth of ovarian cancer and teratocarcinoma cell lines. ( 27091127 )
2016
13
Lysine methylation represses p53 activity in teratocarcinoma cancer cells. ( 27535933 )
2016
14
Nicotinamide induces apoptosis of F9 mouse teratocarcinoma stem cells by downregulation of SATB1 expression. ( 25596087 )
2015
15
Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1. ( 25746218 )
2015
16
The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1. ( 25761220 )
2015
17
Pleuritis caused by Acremonium strictum in a patient with metastatic testicular teratocarcinoma. ( 26042869 )
2015
18
Ligand-independent androgen receptors promote ovarian teratocarcinoma cell growth by stimulating self-renewal of cancer stem/progenitor cells. ( 24793306 )
2014
19
Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/β-catenin signaling. ( 25138740 )
2014
20
Extracellular syntaxin4 triggers the differentiation program in teratocarcinoma F9 cells that impacts cell adhesion properties. ( 23884628 )
2013
21
MicroRNA-21 promotes the ovarian teratocarcinoma PA1 cell line by sustaining cancer stem/progenitor populations in vitro. ( 23890123 )
2013
22
Murine teratocarcinoma-derived neuronal cultures. ( 23975819 )
2013
23
Teratocarcinoma in a non seminomatous, mixed germ cell tumour of the testis-a rare entity. ( 23998086 )
2013
24
KSRP silencing favors neural differentiation of P19 teratocarcinoma cells. ( 23462617 )
2013
25
Development of experimental tumors formed by mouse and human embryonic stem and teratocarcinoma cells after subcutaneous and intraperitoneal transplantations into immunodeficient and immunocompetent mice. ( 23051679 )
2013
26
MicroRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonic carcinoma P19 cells. ( 23007514 )
2013
27
Presacral teratocarcinoma presenting as anal fistula and rectal adenocarcinoma: a unique case presentation and literature review. ( 22611366 )
2012
28
Wnt/β-catenin signaling pathway upregulates c-Myc expression to promote cell proliferation of P19 teratocarcinoma cells. ( 22976998 )
2012
29
Teratocarcinoma formation in embryonic stem cell-derived neural progenitor hippocampal transplants. ( 22776287 )
2012
30
Primary CNS teratocarcinoma. ( 22363315 )
2012
31
Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea. ( 22100652 )
2011
32
A spontaneous teratocarcinoma in the testis of a swiss albino mouse. ( 21270422 )
2011
33
Unusual autopsy finding in a case of metastatic teratocarcinoma. ( 21109467 )
2011
34
Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell. ( 19943082 )
2011
35
Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect. ( 19853938 )
2011
36
A teratocarcinoma-like human embryonic stem cell (hESC) line and four hESC lines reveal potentially oncogenic genomic changes. ( 20428235 )
2010
37
Effects of insulin-like growth factor binding protein 7 on apoptosis in human teratocarcinoma cells in vitro. ( 20393014 )
2010
38
Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. ( 20385969 )
2010
39
Suppression of teratocarcinoma growth by soluble TRAIL gene expression driven by the progression-elevated gene-3 promoter. ( 19823015 )
2009
40
Angiogenesis and vascular network of teratocarcinoma from embryonic stem cell transplant into seminiferous tubules. ( 19513074 )
2009
41
Mediastinal teratocarcinoma as initial manifestation of asymptomatic HIV infection: a case report. ( 18663349 )
2008
42
Primary mediastinal giant teratocarcinoma. ( 18626155 )
2008
43
Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke. ( 18514379 )
2008
44
Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells. ( 18237746 )
2008
45
Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells. ( 18164278 )
2008
46
Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm. ( 17993262 )
2008
47
Testicular teratocarcinoma associated with testicular microlithiasis. ( 17464445 )
2008
48
Cervical mature teratoma 17 years after initial treatment of testicular teratocarcinoma: report of a late relapse. ( 17201931 )
2007
49
Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. ( 17875646 )
2007
50
22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. ( 17689017 )
2007

Variations for Teratocarcinoma

Expression for Teratocarcinoma

Search GEO for disease gene expression data for Teratocarcinoma.

Pathways for Teratocarcinoma

GO Terms for Teratocarcinoma

Biological processes related to Teratocarcinoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.96 FGF4 JUN RARA RARB TDGF1
2 positive regulation of cell proliferation GO:0008284 9.85 FGF4 JUN RARA TDGF1
3 liver development GO:0001889 9.71 JUN RARA RARB
4 response to lipid GO:0033993 9.59 RARA RARB
5 regulation of myelination GO:0031641 9.58 RARA RARB
6 steroid hormone mediated signaling pathway GO:0043401 9.58 NR6A1 RARA RARB
7 retinoic acid receptor signaling pathway GO:0048384 9.57 RARA RARB
8 somatic stem cell population maintenance GO:0035019 9.54 NANOG POU5F1 TDGF1
9 growth plate cartilage development GO:0003417 9.52 RARA RARB
10 negative regulation of cartilage development GO:0061037 9.51 RARA RARB
11 nodal signaling pathway GO:0038092 9.49 TDGF1 TDGF1P3
12 epithelium development GO:0060429 9.48 RARA RARB
13 gland development GO:0048732 9.43 RARA RARB
14 chondroblast differentiation GO:0060591 9.32 FGF4 RARA
15 endodermal cell fate specification GO:0001714 9.26 NANOG POU5F1
16 ventricular cardiac muscle cell differentiation GO:0055012 9.16 RARA RARB
17 glandular epithelial cell development GO:0002068 8.96 RARA RARB
18 transcription, DNA-templated GO:0006351 8.32 JUN
19 multicellular organism development GO:0007275 10.06 CRABP1 FGF4 NANOG POU5F1 RARA RARB
20 positive regulation of transcription by RNA polymerase II GO:0045944 10 FGF4 JUN NANOG NR6A1 POU5F1 RARA

Molecular functions related to Teratocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.88 JUN NANOG NR6A1 POU5F1 RARA RARB
2 transcription factor binding GO:0008134 9.73 ENPP2 JUN RARA RARB
3 sequence-specific DNA binding GO:0043565 9.73 JUN NANOG NR6A1 POU5F1 RARA RARB
4 transcription regulatory region sequence-specific DNA binding GO:0000976 9.54 POU5F1 RARA RARB
5 steroid hormone receptor activity GO:0003707 9.5 NR6A1 RARA RARB
6 activin receptor binding GO:0070697 9.16 TDGF1 TDGF1P3
7 nodal binding GO:0038100 8.96 TDGF1 TDGF1P3
8 nuclear receptor activity GO:0004879 8.8 NR6A1 RARA RARB

Sources for Teratocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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