MCID: TRT001
MIFTS: 44

Teratocarcinoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Teratocarcinoma

MalaCards integrated aliases for Teratocarcinoma:

Name: Teratocarcinoma 12 55 44 15 72
Mixed Embryonal Carcinoma and Teratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3305
MeSH 44 D018243
NCIt 50 C3756
SNOMED-CT 68 67830002
UMLS 72 C0206664

Summaries for Teratocarcinoma

Disease Ontology : 12 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards based summary : Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to germ cell cancer and embryonal carcinoma. An important gene associated with Teratocarcinoma is MIR302A (MicroRNA 302a), and among its related pathways/superpathways are Developmental Biology and Nanog in Mammalian ESC Pluripotency. The drugs Valproic acid and Azacitidine have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and brain, and related phenotypes are embryo and mortality/aging

Wikipedia : 75 A germ-cell tumor (GCT) is a neoplasm derived from germ cells. Germ-cell tumors can be cancerous or... more...

Related Diseases for Teratocarcinoma

Diseases related to Teratocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 germ cell cancer 29.4 POU5F1 NANOG FGF4
2 embryonal carcinoma 28.7 TDGF1 RARB RARA POU5F1 NR6A1 JUN
3 childhood teratocarcinoma of the testis 12.3
4 teratoma 10.8
5 germ cells tumors 10.4
6 neuroblastoma 1 10.3
7 testicular cancer 10.3
8 mature teratoma 10.3
9 choriocarcinoma 10.3
10 seminoma 10.3
11 erythroleukemia, familial 10.2
12 cholera 10.2
13 testicular germ cell tumor 10.2
14 pertussis 10.2
15 severe combined immunodeficiency 10.2
16 teratoma, ovarian 10.1
17 insulin-like growth factor i 10.1
18 testicular germ cell cancer 10.1
19 malignant teratoma 10.1
20 ovarian germ cell teratoma 10.1
21 herpes simplex 10.1
22 stomatitis 10.1
23 rare tumor 10.1
24 ovarian embryonal carcinoma 10.1 POU5F1 NANOG
25 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 10.1 POU5F1 NANOG
26 breast cancer 10.0
27 ovarian cancer 10.0
28 pheochromocytoma 10.0
29 immune deficiency disease 10.0
30 enhanced s-cone syndrome 10.0
31 ouabain resistance 10.0
32 human immunodeficiency virus type 1 10.0
33 testicular microlithiasis 10.0
34 adrenal gland pheochromocytoma 10.0
35 hydrocephalus 10.0
36 endodermal sinus tumor 10.0
37 adenocarcinoma 10.0
38 testicular yolk sac tumor 10.0
39 embryonal testis carcinoma 10.0
40 in situ carcinoma 10.0
41 47,xyy 10.0
42 chromosomal triplication 10.0
43 congenital hydrocephalus 10.0
44 splenomegaly 10.0
45 cytomegalovirus infection 10.0
46 overgrowth syndrome 10.0
47 venous hemangioma 10.0 POU5F1 NANOG
48 mixed germ cell cancer 9.9 TDGF1 POU5F1 CRABP1
49 hypercarotenemia and vitamin a deficiency, autosomal dominant 9.9 RARB RARA
50 alzheimer disease 9.9

Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to Teratocarcinoma

Symptoms & Phenotypes for Teratocarcinoma

MGI Mouse Phenotypes related to Teratocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.96 ENPP2 FGF4 JUN LAMB1 NANOG NR6A1
2 mortality/aging MP:0010768 9.73 CRABP1 ENPP2 FGF2 FGF4 JUN LAMB1
3 limbs/digits/tail MP:0005371 9.63 CRABP1 FGF4 LAMB1 NR6A1 RARA RARB
4 normal MP:0002873 9.23 CRABP1 ENPP2 FGF4 JUN POU5F1 RARA

Drugs & Therapeutics for Teratocarcinoma

Drugs for Teratocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic acid Approved, Investigational Phase 2 99-66-1 3121
2
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
3
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
4 Neurotransmitter Agents Phase 2
5 Tranquilizing Agents Phase 2
6 Psychotropic Drugs Phase 2
7 Central Nervous System Depressants Phase 2
8 GABA Agents Phase 2
9 Histone Deacetylase Inhibitors Phase 2
10 Keratolytic Agents Phase 2
11 Dermatologic Agents Phase 2
12 Antimetabolites Phase 2
13 Antimanic Agents Phase 2
14 Anticonvulsants Phase 2
15 Antimetabolites, Antineoplastic Phase 2
16 Analgesics, Non-Narcotic Phase 1
17 Analgesics Phase 1
18 Peripheral Nervous System Agents Phase 1
19 Interleukin-2 Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multi Centers, Open-trial Phase II Study Evaluating 5-azacytidine (Vidaza®) + Valproic Acid (Depakine ®) Before Administration of Retinoic Acid (Vesanoid®) in Patients With Acute Myelogenous Leukemia and High Risk Myelodysplasia. Completed NCT00339196 Phase 2 5 azacytidine - VALPROIC acid- Retinoic acid
2 Phase I Clinical Study Combining L19-IL2 With Stereotactic Ablative Body Radiotherapy in Patients With Oligometastatic Solid Tumor. Completed NCT02086721 Phase 1 L19-IL2

Search NIH Clinical Center for Teratocarcinoma

Cochrane evidence based reviews: teratocarcinoma

Genetic Tests for Teratocarcinoma

Anatomical Context for Teratocarcinoma

MalaCards organs/tissues related to Teratocarcinoma:

41
Testis, Ovary, Brain, Lung, Bone, Pineal, Kidney

Publications for Teratocarcinoma

Articles related to Teratocarcinoma:

(show top 50) (show all 2288)
# Title Authors PMID Year
1
Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. 38 88
17716626 2007
2
Effects of insulin-like growth factor binding protein 7 on apoptosis in human teratocarcinoma cells in vitro. 9 38
20393014 2010
3
Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation. 9 38
19917671 2010
4
Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. 9 38
17875646 2007
5
Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. 9 38
17663992 2007
6
22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. 9 38
17689017 2007
7
Germ cell nuclear factor is a repressor of CRIPTO-1 and CRIPTO-3. 9 38
16954206 2006
8
Strategies for examination of Alzheimer's disease amyloid precursor protein isoforms. 9 38
16741768 2006
9
Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line. 9 38
16369771 2006
10
Expression of human endogenous retrovirus K in melanomas and melanoma cell lines. 9 38
15899808 2005
11
Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). 9 38
15734730 2005
12
Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. 9 38
15710986 2005
13
Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor. 9 38
15381082 2004
14
Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity. 9 38
15189344 2004
15
Expression of septin 3 isoforms in human brain. 9 38
15200239 2004
16
Glutamate receptor RNA editing: a molecular analysis of GluR2, GluR5 and GluR6 in human brain tissues and in NT2 cells following in vitro neural differentiation. 9 38
14559151 2003
17
Effects of fibroblast growth factor 8, fibroblast growth factor 9 and keratinocyte growth factor on multiplication and locomotion in human teratocarcinoma cells in vitro. 9 38
12820388 2003
18
RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. 9 38
12492469 2003
19
Differential regulation of WNT2 and WNT2B expression in human cancer. 9 38
11712082 2001
20
Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors. 9 38
11764380 2001
21
Alpha-synuclein expression is up-regulated in NTera2 cells during neuronal differentiation but unaffected by exposure to cytokines and neurotrophic factors. 9 38
11472875 2001
22
Disassociation of MAPK activation and c-Fos expression in F9 embryonic carcinoma cells following retinoic acid-induced endoderm differentiation. 9 38
11402055 2001
23
Genomic organization of the human GRIK2 gene and evidence for multiple splicing variants. 9 38
11675011 2001
24
Ubiquitin C-terminal hydrolase-L1 (PGP9.5) expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines, neurotrophic factors or heat stress. 9 38
11437990 2001
25
Effects of insulin-like growth factor-binding protein 2 and an IGF-type I receptor-blocking antibody on apoptosis in human teratocarcinoma cells in vitro. 9 38
11482908 2001
26
Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors. 9 38
11211053 2000
27
Trophinin expression in the mouse uterus coincides with implantation and is hormonally regulated but not induced by implanting blastocysts. 9 38
11089559 2000
28
Molecular cloning and analysis of a group of genes differentially expressed in cells which overexpress the Hoxa-1 homeobox gene. 9 38
10942599 2000
29
Isolation of human type 2 deiodinase gene promoter and characterization of a functional cyclic adenosine monophosphate response element. 9 38
10803591 2000
30
Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. 9 38
10669732 2000
31
Keratinocyte growth factor in the promotion of human chorionic gonadotropin production in human choriocarcinoma cells. 9 38
10739532 2000
32
Green fluorescent protein as a quantitative tool. 9 38
10752489 2000
33
Polyamine depletion up-regulates c-Myc expression, yet induces G(1) arrest and terminal differentiation of F9 teratocarcinoma stem cells. 9 38
10581008 1999
34
Autotaxin expression in non-small-cell lung cancer. 9 38
10423404 1999
35
ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation. 9 38
10442638 1999
36
Neuronal differentiation of NT2/D1 teratocarcinoma cells is accompanied by a loss of lamin A/C expression and an increase in lamin B1 expression. 9 38
10364436 1999
37
Lithium chloride induces the expression of tyrosine hydroxylase in hNT neurons. 9 38
10364437 1999
38
PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation. 9 38
9889285 1999
39
Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. 9 38
10371304 1999
40
Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1. 9 38
10393436 1999
41
Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro. 9 38
9880584 1999
42
Coactivator PC4 mediates AP-2 transcriptional activity and suppresses ras-induced transformation dependent on AP-2 transcriptional interference. 9 38
9858613 1999
43
Negative feedback control of the retinoid-retinoic acid/retinoid X receptor pathway by the human TR4 orphan receptor, a member of the steroid receptor superfamily. 9 38
9593676 1998
44
A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. 9 38
9560222 1998
45
Retinoic acid differentially regulates retinoic acid receptor-mediated pathways in the Hep3B cell line. 9 38
9457077 1998
46
Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2. 9 38
10612460 1998
47
Human endogenous retrovirus (HERV)-K transcripts in germ cell and trophoblastic tumours. 9 38
9524581 1998
48
Increased expression of c-jun, but not retinoic acid receptor beta, is associated with F9 teratocarcinoma stem cell differentiation induced by polyamine depletion. 9 38
9361192 1997
49
Regulation of the laminin beta 1 (LAMB1), retinoic acid receptor beta, and bone morphogenetic protein 2 genes in mutant F9 teratocarcinoma cell lines partially deficient in cyclic AMP-dependent protein kinase activity. 9 38
9419418 1997
50
Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1. 9 38
9285688 1997

Variations for Teratocarcinoma

Expression for Teratocarcinoma

Search GEO for disease gene expression data for Teratocarcinoma.

Pathways for Teratocarcinoma

Pathways related to Teratocarcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 TDGF1P3 TDGF1 RARB RARA POU5F1 NR6A1
2
Show member pathways
13.08 TDGF1 POU5F1 NANOG JUN FGF4 FGF2
3 12.52 RARB RARA LAMB1 JUN FGF4 FGF2
4
Show member pathways
12.1 TDGF1 POU5F1 NANOG FGF4 FGF2
5 12.04 TDGF1 POU5F1 NR6A1 NANOG
6 11.79 POU5F1 NANOG FGF4 FGF2
7
Show member pathways
11.67 RARB RARA NR6A1
8
Show member pathways
11.51 RARB RARA CRABP1
9 11.45 POU5F1 NANOG MIR302A
10 11.36 POU5F1 NANOG FGF2
11 11.25 RARB RARA CRABP1
12 11.21 JUN FGF4 FGF2
13 10.85 TDGF1 LAMB1 JUN FGF4 FGF2
14
Show member pathways
10.71 TDGF1 POU5F1 NR6A1 NANOG FGF2
15
Show member pathways
10.52 POU5F1 NANOG
16 10.49 POU5F1 NR6A1 NANOG FGF4

GO Terms for Teratocarcinoma

Biological processes related to Teratocarcinoma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 TDGF1 RARB RARA JUN FGF4
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.86 RARB RARA POU5F1 NR6A1 NANOG JUN
3 positive regulation of cell proliferation GO:0008284 9.8 TDGF1 RARA JUN FGF4 FGF2
4 liver development GO:0001889 9.74 RARB RARA JUN
5 steroid hormone mediated signaling pathway GO:0043401 9.65 RARB RARA NR6A1
6 cell migration involved in sprouting angiogenesis GO:0002042 9.61 TDGF1 FGF2
7 regulation of myelination GO:0031641 9.6 RARB RARA
8 retinoic acid receptor signaling pathway GO:0048384 9.59 RARB RARA
9 growth plate cartilage development GO:0003417 9.56 RARB RARA
10 nodal signaling pathway GO:0038092 9.55 TDGF1P3 TDGF1
11 negative regulation of cartilage development GO:0061037 9.54 RARB RARA
12 epithelium development GO:0060429 9.52 RARB RARA
13 gland development GO:0048732 9.49 RARB RARA
14 ventricular cardiac muscle cell differentiation GO:0055012 9.46 RARB RARA
15 endodermal cell fate specification GO:0001714 9.43 POU5F1 NANOG
16 regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000544 9.37 FGF4 FGF2
17 glandular epithelial cell development GO:0002068 9.32 RARB RARA
18 somatic stem cell population maintenance GO:0035019 9.26 TDGF1 POU5F1 NANOG FGF2
19 transcription, DNA-templated GO:0006351 8.85 JUN
20 chondroblast differentiation GO:0060591 8.8 RARA FGF4 FGF2
21 cell differentiation GO:0030154 10.06 TDGF1 RARB RARA NANOG FGF4 FGF2
22 multicellular organism development GO:0007275 10.05 RARB RARA POU5F1 NANOG FGF4 FGF2

Molecular functions related to Teratocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.93 RARB RARA POU5F1 NR6A1 NANOG JUN
2 transcription factor binding GO:0008134 9.78 RARB RARA JUN ENPP2
3 sequence-specific DNA binding GO:0043565 9.73 RARB RARA POU5F1 NR6A1 NANOG JUN
4 growth factor activity GO:0008083 9.62 TDGF1P3 TDGF1 FGF4 FGF2
5 transcription regulatory region sequence-specific DNA binding GO:0000976 9.61 RARB RARA POU5F1
6 nuclear receptor transcription coactivator activity GO:0030374 9.58 RARB RARA FGF2
7 steroid hormone receptor activity GO:0003707 9.54 RARB RARA NR6A1
8 nodal binding GO:0038100 9.16 TDGF1P3 TDGF1
9 activin receptor binding GO:0070697 8.96 TDGF1P3 TDGF1
10 nuclear receptor activity GO:0004879 8.8 RARB RARA NR6A1

Sources for Teratocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....