MCID: TRT001
MIFTS: 41

Teratocarcinoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Teratocarcinoma

MalaCards integrated aliases for Teratocarcinoma:

Name: Teratocarcinoma 12 54 44 15 70
Mixed Embryonal Carcinoma and Teratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3305
MeSH 44 D018243
NCIt 50 C3756
SNOMED-CT 67 67830002
UMLS 70 C0206664

Summaries for Teratocarcinoma

Disease Ontology : 12 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.

MalaCards based summary : Teratocarcinoma, also known as mixed embryonal carcinoma and teratoma, is related to mature teratoma and embryonal carcinoma. An important gene associated with Teratocarcinoma is MIR302A (MicroRNA 302a), and among its related pathways/superpathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. Affiliated tissues include testis, ovary and pineal, and related phenotypes are embryo and cellular

Wikipedia : 73 Germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ-cell tumors can be cancerous or... more...

Related Diseases for Teratocarcinoma

Diseases related to Teratocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 mature teratoma 30.4 POU5F1 NANOG MIR302A
2 embryonal carcinoma 30.1 TDGF1 RARB RARA POU5F1 NR6A1 NANOG
3 malignant teratoma 29.9 POU5F1 NANOG
4 germ cell cancer 29.4 POU5F1 NANOG MIR302A FGF4 FGF2
5 childhood teratocarcinoma of the testis 11.1
6 teratoma 10.6
7 germ cells tumors 10.3
8 keratomalacia 10.2 RARB RARA
9 neuroblastoma 10.2
10 dysgerminoma of ovary 10.2 POU5F1 NANOG
11 midline interhemispheric variant of holoprosencephaly 10.2 TDGF1 FGF8
12 testicular cancer 10.2
13 septopreoptic holoprosencephaly 10.2 TDGF1 FGF8
14 malignant giant cell tumor of soft parts 10.2 POU5F1 NANOG
15 central nervous system germinoma 10.2 POU5F1 MIR302A
16 cardiomyopathy, familial hypertrophic, 25 10.2 POU5F1 NANOG JUN
17 choriocarcinoma 10.2
18 seminoma 10.2
19 macular degeneration, age-related, 7 10.1 POU5F1 NANOG
20 acute erythroid leukemia 10.1
21 cholera 10.1
22 alobar holoprosencephaly 10.1 TDGF1 FGF8
23 teratoma, ovarian 10.1
24 testicular germ cell tumor 10.1
25 pertussis 10.1
26 ovarian germ cell teratoma 10.1
27 pelizaeus-merzbacher disease 10.1 RAN POU5F1 NANOG FGF2
28 lobar holoprosencephaly 10.0 TDGF1 FGF8
29 apert syndrome 10.0 FGF8 FGF4 FGF2
30 insulin-like growth factor i 10.0
31 severe combined immunodeficiency 10.0
32 stomatitis 10.0
33 rare tumor 10.0
34 crouzon syndrome 10.0 FGF8 FGF4 FGF2
35 pheochromocytoma 9.9
36 ouabain resistance 9.9
37 testicular microlithiasis 9.9
38 adrenal gland pheochromocytoma 9.9
39 human cytomegalovirus infection 9.9
40 hydrocephalus 9.9
41 adenocarcinoma 9.9
42 embryonal testis carcinoma 9.9
43 in situ carcinoma 9.9
44 germ cell and embryonal cancer 9.8 TDGF1 POU5F1 NANOG MIR302A FGF4 FGF2
45 alzheimer disease 9.8
46 epidermoid cysts 9.8
47 hypercholesterolemia, familial, 1 9.8
48 systemic lupus erythematosus 9.8
49 ovarian cancer 9.8
50 polykaryocytosis inducer 9.8

Graphical network of the top 20 diseases related to Teratocarcinoma:



Diseases related to Teratocarcinoma

Symptoms & Phenotypes for Teratocarcinoma

MGI Mouse Phenotypes related to Teratocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 10.18 DAB2 ENPP2 FGF4 FGF8 JUN LAMB1
2 cellular MP:0005384 10.17 DAB2 ENPP2 FGF2 FGF4 FGF8 JUN
3 mortality/aging MP:0010768 10.13 CRABP1 DAB2 ENPP2 FGF2 FGF4 FGF8
4 limbs/digits/tail MP:0005371 9.92 CRABP1 FGF4 FGF8 JUN LAMB1 NR6A1
5 nervous system MP:0003631 9.9 ENPP2 FGF2 FGF8 JUN LAMB1 NR6A1
6 hearing/vestibular/ear MP:0005377 9.85 CRABP1 FGF2 FGF8 NR6A1 RARA RARB
7 normal MP:0002873 9.65 CRABP1 ENPP2 FGF4 FGF8 JUN POU5F1
8 vision/eye MP:0005391 9.28 CRABP1 FGF2 FGF8 JUN NR6A1 RARA

Drugs & Therapeutics for Teratocarcinoma

Search Clinical Trials , NIH Clinical Center for Teratocarcinoma

Cochrane evidence based reviews: teratocarcinoma

Genetic Tests for Teratocarcinoma

Anatomical Context for Teratocarcinoma

MalaCards organs/tissues related to Teratocarcinoma:

40
Testis, Ovary, Pineal, Prostate, Thymus, Lymph Node, Colon

Publications for Teratocarcinoma

Articles related to Teratocarcinoma:

(show top 50) (show all 2307)
# Title Authors PMID Year
1
Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. 47 61
17716626 2007
2
Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation. 54 61
19917671 2010
3
Effects of insulin-like growth factor binding protein 7 on apoptosis in human teratocarcinoma cells in vitro. 61 54
20393014 2010
4
Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. 54 61
17875646 2007
5
Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. 54 61
17663992 2007
6
22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. 54 61
17689017 2007
7
Germ cell nuclear factor is a repressor of CRIPTO-1 and CRIPTO-3. 54 61
16954206 2006
8
Strategies for examination of Alzheimer's disease amyloid precursor protein isoforms. 61 54
16741768 2006
9
Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line. 54 61
16369771 2006
10
Expression of human endogenous retrovirus K in melanomas and melanoma cell lines. 61 54
15899808 2005
11
Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). 54 61
15734730 2005
12
Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. 54 61
15710986 2005
13
Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor. 54 61
15381082 2004
14
Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity. 61 54
15189344 2004
15
Expression of septin 3 isoforms in human brain. 54 61
15200239 2004
16
Glutamate receptor RNA editing: a molecular analysis of GluR2, GluR5 and GluR6 in human brain tissues and in NT2 cells following in vitro neural differentiation. 54 61
14559151 2003
17
Effects of fibroblast growth factor 8, fibroblast growth factor 9 and keratinocyte growth factor on multiplication and locomotion in human teratocarcinoma cells in vitro. 61 54
12820388 2003
18
RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. 61 54
12492469 2003
19
Differential regulation of WNT2 and WNT2B expression in human cancer. 61 54
11712082 2001
20
Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors. 54 61
11764380 2001
21
Alpha-synuclein expression is up-regulated in NTera2 cells during neuronal differentiation but unaffected by exposure to cytokines and neurotrophic factors. 61 54
11472875 2001
22
Disassociation of MAPK activation and c-Fos expression in F9 embryonic carcinoma cells following retinoic acid-induced endoderm differentiation. 61 54
11402055 2001
23
Genomic organization of the human GRIK2 gene and evidence for multiple splicing variants. 61 54
11675011 2001
24
Ubiquitin C-terminal hydrolase-L1 (PGP9.5) expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines, neurotrophic factors or heat stress. 54 61
11437990 2001
25
Effects of insulin-like growth factor-binding protein 2 and an IGF-type I receptor-blocking antibody on apoptosis in human teratocarcinoma cells in vitro. 54 61
11482908 2001
26
Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors. 61 54
11211053 2000
27
Trophinin expression in the mouse uterus coincides with implantation and is hormonally regulated but not induced by implanting blastocysts. 61 54
11089559 2000
28
Molecular cloning and analysis of a group of genes differentially expressed in cells which overexpress the Hoxa-1 homeobox gene. 54 61
10942599 2000
29
Isolation of human type 2 deiodinase gene promoter and characterization of a functional cyclic adenosine monophosphate response element. 54 61
10803591 2000
30
Keratinocyte growth factor in the promotion of human chorionic gonadotropin production in human choriocarcinoma cells. 61 54
10739532 2000
31
Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. 54 61
10669732 2000
32
Green fluorescent protein as a quantitative tool. 54 61
10752489 2000
33
Polyamine depletion up-regulates c-Myc expression, yet induces G(1) arrest and terminal differentiation of F9 teratocarcinoma stem cells. 61 54
10581008 1999
34
ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation. 61 54
10442638 1999
35
Autotaxin expression in non-small-cell lung cancer. 54 61
10423404 1999
36
Lithium chloride induces the expression of tyrosine hydroxylase in hNT neurons. 54 61
10364437 1999
37
Neuronal differentiation of NT2/D1 teratocarcinoma cells is accompanied by a loss of lamin A/C expression and an increase in lamin B1 expression. 61 54
10364436 1999
38
PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation. 54 61
9889285 1999
39
Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. 61 54
10371304 1999
40
Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro. 61 54
9880584 1999
41
Coactivator PC4 mediates AP-2 transcriptional activity and suppresses ras-induced transformation dependent on AP-2 transcriptional interference. 54 61
9858613 1999
42
Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1. 54 61
10393436 1999
43
Negative feedback control of the retinoid-retinoic acid/retinoid X receptor pathway by the human TR4 orphan receptor, a member of the steroid receptor superfamily. 54 61
9593676 1998
44
A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. 61 54
9560222 1998
45
Human endogenous retrovirus (HERV)-K transcripts in germ cell and trophoblastic tumours. 54 61
9524581 1998
46
Retinoic acid differentially regulates retinoic acid receptor-mediated pathways in the Hep3B cell line. 61 54
9457077 1998
47
Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2. 54 61
10612460 1998
48
Regulation of the laminin beta 1 (LAMB1), retinoic acid receptor beta, and bone morphogenetic protein 2 genes in mutant F9 teratocarcinoma cell lines partially deficient in cyclic AMP-dependent protein kinase activity. 61 54
9419418 1997
49
Increased expression of c-jun, but not retinoic acid receptor beta, is associated with F9 teratocarcinoma stem cell differentiation induced by polyamine depletion. 61 54
9361192 1997
50
Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1. 54 61
9285688 1997

Variations for Teratocarcinoma

Expression for Teratocarcinoma

Search GEO for disease gene expression data for Teratocarcinoma.

Pathways for Teratocarcinoma

Pathways related to Teratocarcinoma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 TDGF1 RRAS2 RARB RARA LAMB1 JUN
2
Show member pathways
13.06 TDGF1 RRAS2 POU5F1 NANOG JUN FGF8
3
Show member pathways
12.99 TDGF1 RRAS2 LAMB1 FGF8 FGF4 FGF2
4
Show member pathways
12.96 TDGF1 RRAS2 JUN FGF8 FGF4 FGF2
5 12.69 RRAS2 JUN FGF8 FGF4 FGF2
6
Show member pathways
12.69 RARB JUN FGF8 FGF4 FGF2
7
Show member pathways
12.61 TDGF1P3 TDGF1 RARB RARA POU5F1 NR6A1
8
Show member pathways
12.58 RARB JUN FGF8 FGF4 FGF2
9 12.53 RARB RARA LAMB1 JUN FGF8 FGF4
10
Show member pathways
12.37 RARB POU5F1 NANOG FGF8 DAB2
11
Show member pathways
12.33 JUN FGF8 FGF4 FGF2
12
Show member pathways
12.3 TDGF1 POU5F1 NANOG FGF4 FGF2
13
Show member pathways
12.21 TDGF1 RRAS2 JUN FGF8 FGF4 FGF2
14
Show member pathways
12.17 TDGF1 FGF8 FGF4 FGF2
15 12.14 TDGF1 POU5F1 NR6A1 NANOG
16
Show member pathways
12.13 RRAS2 JUN FGF8 FGF4 FGF2
17 11.94 POU5F1 NANOG FGF4 FGF2
18
Show member pathways
11.79 RARB RARA NR6A1
19
Show member pathways
11.78 FGF8 FGF4 FGF2
20 11.72 FGF8 FGF4 FGF2
21 11.65 TDGF1 FGF8 FGF4 FGF2
22
Show member pathways
11.61 RARB RARA CRABP1
23 11.61 TDGF1 RRAS2 FGF8 FGF4 FGF2
24 11.55 POU5F1 NANOG MIR302A
25
Show member pathways
11.53 FGF8 FGF4 FGF2
26 11.47 POU5F1 NANOG FGF2
27 11.42 FGF8 FGF4 FGF2
28 11.37 RARB RARA CRABP1
29 11.35 JUN FGF4 FGF2
30
Show member pathways
11.04 TDGF1 POU5F1 NR6A1 NANOG FGF2
31 10.86 TDGF1 LAMB1 JUN FGF8 FGF4 FGF2
32 10.69 POU5F1 NR6A1 NANOG FGF4
33
Show member pathways
10.63 POU5F1 NANOG

GO Terms for Teratocarcinoma

Cellular components related to Teratocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.17 RARB RARA RAN POU5F1 NR6A1 NANOG

Biological processes related to Teratocarcinoma according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.22 TDGF1P3 TDGF1 RRAS2 RARB RARA FGF8
2 multicellular organism development GO:0007275 10.13 POU5F1 NANOG FGF8 FGF4 FGF2 DAB2
3 positive regulation of gene expression GO:0010628 10.03 RARA POU5F1 FGF8 FGF4 FGF2
4 negative regulation of transcription by RNA polymerase II GO:0000122 10.02 RARB RARA POU5F1 NR6A1 NANOG JUN
5 positive regulation of cell proliferation GO:0008284 9.97 TDGF1 RARA JUN FGF8 FGF4 FGF2
6 positive regulation of cell migration GO:0030335 9.94 TDGF1 RRAS2 LAMB1 DAB2
7 negative regulation of apoptotic process GO:0043066 9.91 TDGF1 RARB RARA FGF8 FGF4 DAB2
8 positive regulation of protein phosphorylation GO:0001934 9.89 FGF8 FGF4 FGF2 DAB2
9 cell differentiation GO:0030154 9.86 TDGF1 RARB RARA NANOG FGF8 FGF4
10 animal organ morphogenesis GO:0009887 9.84 LAMB1 FGF8 FGF4 FGF2
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.82 TDGF1 FGF8 ENPP2
12 fibroblast growth factor receptor signaling pathway GO:0008543 9.8 FGF8 FGF4 FGF2
13 determination of left/right symmetry GO:0007368 9.79 TDGF1P3 TDGF1 FGF8
14 Ras protein signal transduction GO:0007265 9.79 RRAS2 JUN FGF2
15 bone development GO:0060348 9.75 RARB RARA FGF8
16 positive regulation of cell division GO:0051781 9.7 FGF8 FGF4 FGF2
17 cell migration involved in sprouting angiogenesis GO:0002042 9.65 TDGF1 FGF2
18 retinoic acid receptor signaling pathway GO:0048384 9.65 RARB RARA
19 positive regulation of SMAD protein signal transduction GO:0060391 9.65 POU5F1 DAB2
20 nodal signaling pathway GO:0038092 9.62 TDGF1P3 TDGF1
21 regulation of cell migration GO:0030334 9.62 FGF8 FGF4 FGF2 ENPP2
22 negative regulation of cartilage development GO:0061037 9.61 RARB RARA
23 positive regulation of transcription by RNA polymerase II GO:0045944 9.61 RARB RARA POU5F1 NR6A1 NANOG JUN
24 growth plate cartilage development GO:0003417 9.6 RARB RARA
25 embryonic hindlimb morphogenesis GO:0035116 9.58 RARB FGF8 FGF4
26 ventricular cardiac muscle cell differentiation GO:0055012 9.56 RARB RARA
27 endodermal cell fate specification GO:0001714 9.55 POU5F1 NANOG
28 outflow tract septum morphogenesis GO:0003148 9.54 RARB RARA FGF8
29 glandular epithelial cell development GO:0002068 9.51 RARB RARA
30 regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000544 9.46 FGF4 FGF2
31 somatic stem cell population maintenance GO:0035019 9.46 TDGF1 POU5F1 NANOG FGF2
32 chondroblast differentiation GO:0060591 8.8 RARA FGF4 FGF2

Molecular functions related to Teratocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.85 RARB RARA POU5F1 NR6A1 NANOG JUN
2 sequence-specific DNA binding GO:0043565 9.83 RARB RARA POU5F1 NR6A1 JUN
3 transcription factor binding GO:0008134 9.78 RARA POU5F1 JUN ENPP2
4 transcription regulatory region sequence-specific DNA binding GO:0000976 9.76 RARA POU5F1 NANOG JUN
5 sequence-specific double-stranded DNA binding GO:1990837 9.63 RARB RARA POU5F1 NR6A1 NANOG JUN
6 nuclear receptor activity GO:0004879 9.58 RARB RARA NR6A1
7 nodal binding GO:0038100 9.32 TDGF1P3 TDGF1
8 activin receptor binding GO:0070697 9.26 TDGF1P3 TDGF1
9 fibroblast growth factor receptor binding GO:0005104 9.13 FGF8 FGF4 FGF2
10 growth factor activity GO:0008083 9.02 TDGF1P3 TDGF1 FGF8 FGF4 FGF2

Sources for Teratocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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