MCID: TRT010
MIFTS: 50

Teratoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Teratoma

MalaCards integrated aliases for Teratoma:

Name: Teratoma 12 73 54 6 44 15 70
Teratomas 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3307
MeSH 44 D013724
NCIt 50 C3403
SNOMED-CT 67 36591000119102
UMLS 70 C0039538

Summaries for Teratoma

Disease Ontology : 12 A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers.

MalaCards based summary : Teratoma, also known as teratomas, is related to sacrococcygeal teratoma and mature teratoma. An important gene associated with Teratoma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Wnt / Hedgehog / Notch. The drugs Promethazine and Diphenhydramine have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and pineal, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 A teratoma is a tumor made up of several different types of tissue, such as hair, muscle, teeth, or... more...

Related Diseases for Teratoma

Diseases in the Teratoma family:

Benign Teratoma Malignant Teratoma
Adult Teratoma Intermediate Malignant Teratoma

Diseases related to Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1138)
# Related Disease Score Top Affiliating Genes
1 sacrococcygeal teratoma 33.1 MNX1 CGB7 CGA AFP
2 mature teratoma 32.9 POU5F1 KRT7 KIT ENO2 AFP
3 ovarian germ cell teratoma 32.8 NKX2-1 KRT7 AFP
4 cystic teratoma 32.7 NKX2-1 KRT7 KIT GFAP ENO2 CDX2
5 ovarian cystic teratoma 32.7 NKX2-1 AFP
6 mature teratoma of the ovary 32.6 ENO2 AFP
7 benign teratoma 32.6 NKX2-1 MNX1 KRT7 ENO2 CDX2 AFP
8 pineal region teratoma 32.5 KIT ENO2 AFP
9 malignant teratoma 32.5 SOX2 POU5F1 KIT ENO2 CGB5 CD99
10 endodermal sinus tumor 32.3 KRT7 CGB5 CGB3 AFP
11 polyembryoma 32.1 CGA AFP
12 central nervous system immature teratoma 32.1 SOX2 NES GFAP
13 mixed germ cell cancer 32.0 KIT AFP
14 ovarian germ cell cancer 32.0 NKX2-1 KRT7 KIT AFP
15 rare tumor 31.5 KIT ACTC1
16 nonseminomatous germ cell tumor 31.4 CGB7 CGB5 AFP
17 mixed germ cell tumor 31.3 KIT CGB3 CGA AFP
18 appendix adenocarcinoma 31.3 KRT7 CDX2
19 mucinous adenocarcinoma 31.2 NKX2-1 KRT7 KIT CDX2
20 adenocarcinoma 31.2 NKX2-1 KRT7 KIT CTNNB1 CDX2
21 choriocarcinoma 31.2 CGB7 CGB5 CGB3 CGA
22 chromosomal triplication 31.2 CGB7 CGB3 AFP
23 testicular cancer 31.1 ENO2 CGB5 CGB3 CGA AFP
24 intestinal obstruction 31.0 KRT7 KIT CDX2
25 germinoma 31.0 POU5F1 KIT CGB5 CGB3 CGA AFP
26 obstructive hydrocephalus 30.9 GFAP ENO2 AFP
27 dysgerminoma 30.9 KRT7 KIT ENO2 AFP
28 lymphangioma 30.8 CTNNB1 CDX2 ACTC1
29 pseudomyxoma peritonei 30.8 KRT7 CTNNB1 CDX2
30 ovarian mixed germ cell neoplasm 30.8 KIT CGA AFP
31 neural tube defects 30.8 MNX1 GFAP ENO2 CTNNB1 CGB7 AFP
32 testicular seminoma 30.7 CGB3 AFP
33 leiomyosarcoma 30.7 KIT ENO2 ACTC1
34 neuroendocrine carcinoma 30.7 NKX2-1 KRT7 KIT ENO2
35 carcinosarcoma 30.7 KRT7 KIT CTNNB1 ACTC1
36 papilloma of choroid plexus 30.7 KRT7 GFAP ENO2
37 adenosquamous carcinoma 30.7 NKX2-1 KRT7 KIT
38 ectopic pregnancy 30.7 CGB7 CGB5 CGB3 CGA AFP
39 hydrocele 30.7 KRT7 CGA AFP
40 wilms tumor 1 30.6 NKX2-1 KRT7 ENO2 CTNNB1 ACTC1
41 horseshoe kidney 30.6 NKX2-1 KRT7 ENO2 CDX2 ACTC1
42 hemangioma 30.6 NKX2-1 KRT7 KIT ENO2 CTNNB1 ACTC1
43 seminoma 30.6 SOX2 POU5F1 KIT ENO2 CGB7 CGB5
44 extragonadal germ cell cancer 30.6 CGB5 AFP
45 ganglioneuroma 30.6 GFAP ENO2 CD99
46 trophoblastic neoplasm 30.5 CGB5 CGB3 CGA AFP
47 spindle cell sarcoma 30.5 KRT7 KIT ACTC1
48 embryonal carcinoma 30.5 SOX2 POU5F1 NES KIT CGB5 CGB3
49 small cell carcinoma 30.5 NKX2-1 KRT7 KIT ENO2
50 signet ring cell adenocarcinoma 30.5 KRT7 CTNNB1 CDX2

Graphical network of the top 20 diseases related to Teratoma:



Diseases related to Teratoma

Symptoms & Phenotypes for Teratoma

GenomeRNAi Phenotypes related to Teratoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.17 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.17 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.17 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.17 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.17 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.17 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.17 AFP

MGI Mouse Phenotypes related to Teratoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.03 ACTC1 CDX2 CTNNB1 ENO2 GFAP GRN
2 digestive/alimentary MP:0005381 9.76 CDX2 CTNNB1 GFAP KIT MNX1 NKX2-1
3 nervous system MP:0003631 9.73 ACTC1 CGA CTNNB1 ENO2 GFAP GRN
4 normal MP:0002873 9.28 ACTC1 CDX2 CTNNB1 GFAP KIT MNX1

Drugs & Therapeutics for Teratoma

Drugs for Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Promethazine Approved, Investigational Phase 3 60-87-7 4927
2
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
3
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
4
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
5
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
6
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
7 Histamine H2 Antagonists Phase 3
8 Antibiotics, Antitubercular Phase 3
9 Anti-Bacterial Agents Phase 3
10 Albumin-Bound Paclitaxel Phase 3
11
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
12
Palbociclib Approved, Investigational Phase 2 571190-30-2 5005498 5330286 11431660
13
Ipilimumab Approved Phase 2 477202-00-9
14
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
15
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
16
nivolumab Approved Phase 2 946414-94-4
17
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
18
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
19
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
20
Lenograstim Approved, Investigational Phase 2 135968-09-1
21
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
22
Etoposide Approved Phase 2 33419-42-0 36462
23
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
24
Mesna Approved, Investigational Phase 2 3375-50-6 598
25
Levonorgestrel Approved, Investigational Phase 2 797-63-7, 17489-40-6 13109
26
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
27
Ifosfamide Approved Phase 2 3778-73-2 3690
28
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
29
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
30
Lysine Approved, Nutraceutical Phase 2 56-87-1 5962
31 Angiogenesis Inhibitors Phase 2
32 Protein Kinase Inhibitors Phase 2
33 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
34 Antineoplastic Agents, Immunological Phase 2
35 Antibodies Phase 2
36 Immunoglobulins Phase 2
37 Antibodies, Monoclonal Phase 2
38 Vitamin B9 Phase 2
39 Vitamin B Complex Phase 2
40 Folate Phase 2
41 Antimetabolites Phase 2
42 Folic Acid Antagonists Phase 2
43 topoisomerase I inhibitors Phase 2
44 Antirheumatic Agents Phase 2
45 Pharmaceutical Solutions Phase 2
46 Protective Agents Phase 2
47 Adjuvants, Immunologic Phase 2
48 Immunologic Factors Phase 2
49 Immunosuppressive Agents Phase 2
50 Etoposide phosphate Phase 2

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 SIOP CNS GCT II: Prospective Trial for the Diagnosis and Treatment of Children, Adolescents and Young Adults With Intracranial Germ Cell Tumors Unknown status NCT01424839 Phase 4 Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
2 A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors Unknown status NCT00053352 Phase 3 cisplatin;etoposide
3 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
4 A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
5 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
6 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
7 A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression Completed NCT02300987 Phase 2 LEE011;LEE011 Placebo
8 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
9 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
10 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
11 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Completed NCT01037790 Phase 2 PD-0332991
12 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
13 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
14 Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
15 A Phase II Study of Oxaliplatin in Children With Recurrent Solid Tumors Completed NCT00091182 Phase 2 oxaliplatin
16 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
17 Phase 2 Study of Alisertib as a Single Agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnosed AT/RT Recruiting NCT02114229 Phase 2 alisertib;methotrexate;cisplatin;carboplatin;cyclophosphamide;etoposide;topotecan;vincristine
18 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Active, not recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
19 A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular &Amp; Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor Not yet recruiting NCT04684368 Phase 2 Carboplatin;Etoposide;Ifosfamide;Mesna;Thiotepa
20 Multicenter Single Arm Phase II Study of Single Agent Palifosfamide in Recurrent and Incurable Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
21 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
22 A Phase I Study of SAHA and Temozolomide in Children With Relapsed or Refractory Primary Brain or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
23 A Phase I Study of Sunitinib (SU11248), an Oral Multi-Targeted Tyrosine Kinase Inhibitor, in Children With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
24 A Multi-Center Phase Ib Study of Oxaliplatin (NSC #266046) in Combination With Fluorouracil and Leucovorin in Pediatric Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
25 A Phase I Study of Vorinostat and Bortezomib in Children With Refractory or Recurrent Solid Tumors, Including CNS Tumors and Lymphomas Completed NCT00994500 Phase 1 vorinostat;bortezomib
26 A Phase I Study of Pazopanib as a Single Agent for Children With Relapsed or Refractory Solid Tumors Completed NCT00929903 Phase 1 pazopanib hydrochloride
27 Phase I Feasibility Trial To Study The Safety Of Sealing Resected Pancreatic Surfaces After Partial Distal Pancreatectomy Using Laser Tissue Welding Recruiting NCT03147768 Phase 1
28 A Phase I Study of the Chemoprotectant Amifostine With Autologous Stem Cell Transplantation for High Risk or Relapsed Pediatric Solid Tumors and Brain Tumors Terminated NCT00003926 Phase 1 amifostine trihydrate;busulfan;filgrastim;melphalan;thiotepa
29 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
30 11C-Acetate PET/CT Non-FDG-Avid Tumors Unknown status NCT00687778
31 Anti-1-amino-3-18F-flurocyclobutane-1-carboxylic Acid (Axumin) Positron Emission Tomography/Computed Tomography Prior to Retroperitoneal Lymph Node Dissection for Testicular Cancer Completed NCT03426865 Axumin PET scan
32 The Differences Between Gonadal and Extra-gonadal Malignant Teratomas in Both Genders and the Effects of Chemotherapy Completed NCT04555395
33 Case Report of a 39 Years Old Man That Has Been Cured by a Total Resection of a Anterior Mediastinum Teratoma. Completed NCT00836121
34 A Study of CT Scan Frequency in Patients With Stage I Testicular Teratoma Completed NCT00003420
35 Characterization of At-risk Population and Prognosis Factors for SACRO-coccygeal Teratoma in CURRARINO Syndrome. A Clinical, Molecular and Pathological Study. Completed NCT00780117
36 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355
37 A Prospective Study of Cognitive Function During Chemotherapy for Front-Line Treatment of Ovarian, Primary Peritoneal or Fallopian Tube Cancer Completed NCT01080521
38 Immunohistochemical Evaluation of Protein P16 Expression in Ovarian Germ Cell Tumors. Recruiting NCT04283773
39 Improving Prenatal Parental Counseling in Cases of Sacrococcygeal Teratoma: a Multicenter Retrospective Study With Review of the Literature Recruiting NCT04623658
40 The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study Recruiting NCT02402244
41 Rare Tumor Case Review Terminated NCT00229879

Search NIH Clinical Center for Teratoma

Cochrane evidence based reviews: teratoma

Genetic Tests for Teratoma

Anatomical Context for Teratoma

MalaCards organs/tissues related to Teratoma:

40
Ovary, Testis, Pineal, Lymph Node, Spinal Cord, Pancreas, Tongue

Publications for Teratoma

Articles related to Teratoma:

(show top 50) (show all 14980)
# Title Authors PMID Year
1
Generation of induced pluripotent stem cells from newborn marmoset skin fibroblasts. 61 54
20363201 2010
2
Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells. 54 61
19785009 2010
3
Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours. 61 54
19912360 2009
4
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. 61 54
19826408 2009
5
Basic FGF and Activin/Nodal but not LIF signaling sustain undifferentiated status of rabbit embryonic stem cells. 61 54
19331817 2009
6
Results of retroperitoneal lymph node dissection after chemotherapy in patients with pure seminoma in the orchidectomy specimen but elevated serum alpha-fetoprotein. 61 54
19493258 2009
7
Yolk sac tumor but not seminoma or teratoma is associated with abnormal epigenetic reprogramming pathway and shows frequent hypermethylation of various tumor suppressor genes. 61 54
19245437 2009
8
Alpha-fetoprotein levels correlate with the pathologic grade and surgical outcomes of pediatric retroperitoneal teratomas. 61 54
19198853 2009
9
Progression from an immature teratoma with miliary gliomatosis peritonei to growing teratoma syndrome with nodular gliomatosis peritonei. 61 54
19453084 2009
10
Long-term outcome for men with teratoma found at postchemotherapy retroperitoneal lymph node dissection. 54 61
19156903 2009
11
Isolation of three stem cell lines from human sacrococcygeal teratomas. 61 54
19142973 2009
12
Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature. 54 61
19577382 2009
13
Pineal region tumors--neurosurgical review. 61 54
20088167 2009
14
Distinct GAGE and MAGE-A expression during early human development indicate specific roles in lineage differentiation. 61 54
18611917 2008
15
The distinction of bronchogenic cyst from metastatic testicular teratoma: a light microscopic and immunohistochemical study. 61 54
18628097 2008
16
Neuron-like differentiation and selective ablation of undifferentiated embryonic stem cells containing suicide gene with Oct-4 promoter. 54 61
18393636 2008
17
Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study. 61 54
18525461 2008
18
Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. 54 61
18439155 2008
19
Oncofetal protein glypican-3 distinguishes yolk sac tumor from clear cell carcinoma of the ovary. 61 54
18277882 2008
20
Comparative growth behaviour and characterization of stem cells from human Wharton's jelly. 61 54
18062871 2007
21
Analyses of novel prognostic factors in neuroblastoma patients. 54 61
18057715 2007
22
FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin. 54 61
17875810 2007
23
Expression of Sox2 in mature and immature teratomas of central nervous system. 61 54
17464316 2007
24
Regulated Nodal signaling promotes differentiation of the definitive endoderm and mesoderm from ES cells. 61 54
17535850 2007
25
[Malignant ovarian germ cell tumours: a trial of 36 cases]. 54 61
17350873 2007
26
Glypican 3: a novel marker in testicular germ cell tumors. 61 54
17122513 2006
27
Oncofetal protein glypican-3 in testicular germ-cell tumor. 54 61
16896894 2006
28
Characterization and gene expression profiling of five new human embryonic stem cell lines derived in Taiwan. 54 61
16978057 2006
29
Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma. 61 54
16718353 2006
30
Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression. 61 54
16596424 2006
31
TGF-beta2 allows pluripotent human embryonic stem cell proliferation on E6/E7 immortalized mouse embryonic fibroblasts. 54 61
16494961 2006
32
Pineal region teratoma with high serum and CSF alpha-fetoprotein levels. 61 54
16503489 2006
33
Malignant cervical teratoma: report of a case in a newborn. 61 54
15895292 2005
34
Transcription factor GATA-6 is expressed in malignant endoderm of pediatric yolk sac tumors and in teratomas. 54 61
16006960 2005
35
Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development. 54 61
15774903 2005
36
Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors. 54 61
16512597 2005
37
Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. 54 61
15613854 2005
38
Interpretation of alpha-fetoprotein concentrations in cerebrospinal fluid of infants. 54 61
15802029 2005
39
[The value of cytology in the diagnosis of extragonadal germ cell tumors]. 54 61
15567952 2004
40
Epidemiological and clinical behavior of prepubertal testicular tumors in Korea. 54 61
15247758 2004
41
[Clinical usefulness of circulating tumor markers]. 61 54
15272600 2004
42
Intracranial germ cell tumors: a single institution experience and review of the literature. 54 61
15218952 2004
43
Nestin, a neuroectodermal stem cell marker molecule, is expressed in Leydig cells of the human testis and in some specific cell types from human testicular tumours. 54 61
15127288 2004
44
Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. 61 54
14663834 2003
45
Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells. 54 61
12161760 2002
46
Apoptosis and proliferative activity in mature and immature teratomas of the mediastinum. 61 54
11745252 2001
47
Malignant teratoma of the thyroid with primitive neuroepithelial and mesenchymal sarcomatous components. 54 61
11598856 2001
48
Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. 54 61
10760271 2000
49
Transcription factor GATA-4 is expressed in pediatric yolk sac tumors. 54 61
10595911 1999
50
Methylation imprinting of H19 and SNRPN genes in human benign ovarian teratomas. 61 54
10521301 1999

Variations for Teratoma

ClinVar genetic disease variations for Teratoma:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CTNNB1 NM_001904.4(CTNNB1):c.1876G>T (p.Glu626Ter) SNV Likely pathogenic 523403 rs1553632357 GRCh37: 3:41277912-41277912
GRCh38: 3:41236421-41236421
2 SETBP1 NM_015559.3(SETBP1):c.2614G>A (p.Gly872Arg) SNV Likely pathogenic 523513 rs1555706928 GRCh37: 18:42531919-42531919
GRCh38: 18:44951954-44951954

Expression for Teratoma

Search GEO for disease gene expression data for Teratoma.

Pathways for Teratoma

Pathways related to Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.33 NKX2-1 CTNNB1 CDX2 ACTC1
2 11.98 SOX2 POU5F1 CTNNB1 CDX2 AFP
3
Show member pathways
11.91 CTNNB1 CGB5 CGB3 CGA CDX2
4
Show member pathways
11.7 KIT CGB5 CGB3 CGA
5 11.6 SOX2 NES MNX1 GFAP
6 11.23 SOX2 POU5F1 NKX2-1 CDX2
7 11.15 SOX2 POU5F1 NES CDX2 AFP
8 10.98 SOX2 POU5F1 KIT ACTC1
9 10.77 SOX2 POU5F1 CDX2
10
Show member pathways
10.46 SOX2 POU5F1

GO Terms for Teratoma

Cellular components related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10 SOX2 POU5F1 NES KRT7 KIT GFAP
2 extracellular space GO:0005615 9.28 KIT GRN ENO2 CGB7 CGB5 CGB3
3 transcription factor complex GO:0005667 9.26 SOX2 POU5F1 NKX2-1 CTNNB1

Biological processes related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.91 POU5F1 NKX2-1 MNX1 KIT CTNNB1 CGB5
2 positive regulation of gene expression GO:0010628 9.85 POU5F1 NKX2-1 KIT CTNNB1 ACTC1
3 response to wounding GO:0009611 9.61 SOX2 POU5F1 GFAP
4 forebrain development GO:0030900 9.58 SOX2 NKX2-1 CTNNB1
5 hormone-mediated signaling pathway GO:0009755 9.54 CGB7 CGB5 CGB3
6 female gamete generation GO:0007292 9.33 CGB7 CGB5 CGB3
7 endodermal cell fate specification GO:0001714 9.32 SOX2 POU5F1
8 peptide hormone processing GO:0016486 9.13 CGB5 CGB3 CGA
9 somatic stem cell population maintenance GO:0035019 8.92 SOX2 POU5F1 KIT CDX2

Molecular functions related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 CGB7 CGB5 CGB3 CGA

Sources for Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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