Teratoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: TRT010 MIFTS: 52	Teratoma Categories: Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Download Expand all tables

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Aliases & Classifications for Teratoma

MalaCards integrated aliases for Teratoma:

Name: Teratoma ¹² ⁷⁶ ²⁹ ⁵⁵ ⁶ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3307

MeSH ⁴⁴ D013724

NCIt ⁵⁰ C3403

SNOMED-CT ⁶⁸ 189844009 189846006 189848007 more

UMLS ⁷³ C0039538

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Summaries for Teratoma

Disease Ontology : ¹² A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers.

MalaCards based summary : Teratoma is related to sacrococcygeal teratoma and mature teratoma. An important gene associated with Teratoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Carboplatin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷⁶ A teratoma is a tumor made up of several different types of tissue, such as hair, muscle, or bone. They... more...

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Related Diseases for Teratoma

Diseases in the Teratoma family:

Malignant Teratoma	Adult Teratoma
Intermediate Malignant Teratoma

Diseases related to Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 630)

#	Related Disease	Score	Top Affiliating Genes
1	sacrococcygeal teratoma	34.7	AFP CGA MNX1
2	mature teratoma	34.1	AFP POU5F1 TP53
3	ovarian germ cell teratoma	33.9	KRT7 NKX2-1
4	dermoid cyst	33.6	KIT KRT7 MNX1
5	testicular germ cell tumor	33.5	AFP DMRT1 KIT TP53
6	polyembryoma	33.3	AFP CGA
7	endodermal sinus tumor	33.2	AFP CGB3 KRT7
8	malignant teratoma	32.8	AFP ENO2 NKX2-1 POU5F1 SYP
9	central nervous system teratoma	32.6	GFAP NES SOX2
10	cystic teratoma	31.7	CDX2 ENO2 GFAP KRT7 NKX2-1 SYP
11	pseudomyxoma peritonei	30.8	CDX2 KRT7 TP53
12	mixed germ cell tumor	30.8	AFP CGA CGB3 KIT
13	mucinous adenocarcinoma	30.7	CDX2 KRT7 NKX2-1
14	testicular seminoma	30.7	CGA CGB3
15	testicular cancer	30.7	AFP CGA CGB3
16	ovarian germ cell cancer	30.4	AFP KRT7 NKX2-1
17	hepatoblastoma	30.4	AFP KRT7 TP53
18	ovarian large-cell neuroendocrine carcinoma	30.4	KRT7 SYP
19	embryonal testis carcinoma	30.4	AFP POU5F1
20	testicular yolk sac tumor	30.3	AFP CDX2 POU5F1
21	renal cell carcinoma, papillary, 1	30.2	KIT KRT7 TP53
22	ganglioneuroma	30.2	ENO2 GFAP SYP
23	papilloma of choroid plexus	30.2	GFAP SYP TP53
24	chordoma	30.2	GFAP KRT7 TP53
25	ovarian carcinosarcoma	30.2	ENO2 SYP
26	oligodendroglioma	30.1	ENO2 GFAP SYP TP53
27	endocervical adenocarcinoma	30.1	CDX2 KRT7 TP53
28	malignant mixed mullerian tumor	30.0	KIT KRT7
29	adenosquamous carcinoma	30.0	KRT7 NKX2-1 TP53
30	seminoma	29.6	AFP CGA CGB3 ENO2 KIT POU5F1
31	papillary adenoma	29.5	KRT7 NKX2-1
32	ependymoma	29.5	ENO2 GFAP NES SYP
33	medullomyoblastoma	29.4	ENO2 GFAP SYP TP53
34	neuroendocrine tumor	29.4	ENO2 KRT7 NKX2-1 SYP
35	adenoid cystic carcinoma	29.4	ACTC1 KIT KRT7 TP53
36	ovarian embryonal carcinoma	29.3	AFP POU5F1 SOX2
37	leiomyosarcoma	29.2	ACTC1 ENO2 KIT TP53
38	glomus tumor	29.1	ACTC1 ENO2 SYP TP53
39	central neurocytoma	29.1	ENO2 GFAP NES SYP
40	large cell neuroendocrine carcinoma	29.0	ENO2 KIT KRT7 NKX2-1 SYP
41	embryonal carcinoma	28.7	AFP KIT NES POU5F1 SOX2
42	hydrocephalus	28.7	ENO2 GFAP NES SYP TP53
43	small cell carcinoma	28.7	ENO2 KIT KRT7 NKX2-1 SYP TP53
44	horseshoe kidney	28.5	ACTC1 CDX2 ENO2 KRT7 NKX2-1 SYP
45	gliosarcoma	28.3	ACTC1 ENO2 GFAP NES TP53
46	medulloblastoma	27.0	ENO2 GFAP NES SOX2 SYP TP53
47	growing teratoma syndrome	12.2
48	teratoma with malignant transformation	12.2
49	immature teratoma of ovary	12.0
50	gastric teratoma	12.0

Graphical network of the top 20 diseases related to Teratoma:

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Symptoms & Phenotypes for Teratoma

GenomeRNAi Phenotypes related to Teratoma according to GeneCards Suite gene sharing:

²⁶ (show all 11)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-114	9.47	AFP
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	9.47	AFP
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	9.47	POU5F1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	9.47	POU5F1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-135	9.47	KRT7
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	9.47	POU5F1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-192	9.47	KRT7 POU5F1 AFP
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	9.47	AFP
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.47	POU5F1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.47	AFP
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.47	KRT7 POU5F1

MGI Mouse Phenotypes related to Teratoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.21	GFAP GRN KIT KRT7 MNX1 NKX2-1
2	behavior/neurological	MP:0005386	10.2	NKX2-1 POU5F1 SOX2 SYP TP53 AFP
3	homeostasis/metabolism	MP:0005376	10.1	ACTC1 AFP CDX2 CGA GFAP GRN
4	endocrine/exocrine gland	MP:0005379	10.07	AFP CDX2 CGA DMRT1 KIT MNX1
5	digestive/alimentary	MP:0005381	10.01	CDX2 GFAP KIT MNX1 NKX2-1 POU5F1
6	nervous system	MP:0003631	9.9	CGA ENO2 GFAP GRN KIT MNX1
7	neoplasm	MP:0002006	9.73	TP53 AFP CDX2 KIT NKX2-1 SOX2
8	normal	MP:0002873	9.65	NKX2-1 POU5F1 SOX2 SYP TP53 ACTC1
9	reproductive system	MP:0005389	9.32	AFP CDX2 CGA DMRT1 GRN KIT

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Drugs & Therapeutics for Teratoma

Drugs for Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Carboplatin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

41575-94-4

10339178 498142 38904

Cisplatin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

15663-27-1

84093 441203 2767

Etoposide

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

33419-42-0

36462

Ifosfamide

Approved

Phase 4,Phase 3,Phase 2,Phase 1

3778-73-2

3690

Mechlorethamine

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2

51-75-2

4033

Alkylating Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antineoplastic Agents, Alkylating

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antineoplastic Agents, Phytogenic

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Etoposide phosphate

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Isophosphamide mustard

Phase 4,Phase 3,Phase 2,Phase 1

Topoisomerase Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Bleomycin

Approved, Investigational

Phase 3,Phase 2,Not Applicable

11056-06-7

5360373

Oxaliplatin

Approved, Investigational

Phase 3,Phase 2,Phase 1

61825-94-3

5310940 9887054 43805 6857599

Paclitaxel

Approved, Vet_approved

Phase 3,Phase 2,Phase 1,Not Applicable

33069-62-4

36314

Lenograstim

Approved, Investigational

Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable

135968-09-1

Vinblastine

Approved

Phase 3

865-21-4

13342 241903

Cyclophosphamide

Approved, Investigational

Phase 3,Phase 2,Phase 1,Not Applicable

50-18-0, 6055-19-2

2907

Dexamethasone

Approved, Investigational, Vet_approved

Phase 3,Phase 2,Phase 1

50-02-2

5743

Mesna

Approved, Investigational

Phase 3,Phase 1,Phase 2,Not Applicable

3375-50-6

598

Captopril

Approved

Phase 3

62571-86-2

44093

Palivizumab

Approved, Investigational

Phase 3

188039-54-5

Ribavirin

Approved

Phase 3

36791-04-5

37542

Fluconazole

Approved, Investigational

Phase 3

86386-73-4

3365

Itraconazole

Approved, Investigational

Phase 3

84625-61-6

55283

Miconazole

Approved, Investigational, Vet_approved

Phase 3

22916-47-8

4189

Amphotericin B

Approved, Investigational

Phase 3

1397-89-3

14956 5280965

Caspofungin

Approved

Phase 3

179463-17-3, 162808-62-0

468682 2826718

Granisetron

Approved, Investigational

Phase 3

109889-09-0

3510

Ondansetron

Approved

Phase 3

99614-02-5

4595

Vincristine

Approved, Investigational

Phase 3,Phase 2,Phase 1

2068-78-2, 57-22-7

5978

Diphenhydramine

Approved, Investigational

Phase 3

147-24-0, 58-73-1

3100

Promethazine

Approved, Investigational

Phase 3

60-87-7

4927

Albumin-Bound Paclitaxel

Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Bacterial Agents

Phase 3,Phase 2,Phase 1,Not Applicable

Antibiotics, Antitubercular

Phase 3,Phase 2,Phase 1,Not Applicable

Antimitotic Agents

Phase 3,Phase 2,Phase 1,Not Applicable

Antirheumatic Agents

Phase 3,Phase 2,Phase 1,Not Applicable

Immunosuppressive Agents

Phase 3,Phase 1,Phase 2,Not Applicable

Anti-Infective Agents

Phase 3,Phase 1,Phase 2

Antimetabolites

Phase 3,Phase 1,Phase 2

Antiviral Agents

Phase 3,Phase 1,Phase 2

Hormone Antagonists

Phase 3,Phase 2,Phase 1

Hormones

Phase 3,Phase 2,Phase 1

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3,Phase 2,Phase 1

Liver Extracts

Phase 3,Phase 2,Phase 1

Antiemetics

Phase 3,Phase 2,Phase 1

Autonomic Agents

Phase 3,Phase 2,Phase 1

BB 1101

Phase 3,Phase 2,Phase 1

Dexamethasone acetate

Phase 3,Phase 2,Phase 1

1177-87-3

Gastrointestinal Agents

Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 101)

#	Name	Status	NCT ID	Phase	Drugs
1	Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors	Recruiting	NCT01424839	Phase 4	Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
2	Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors	Unknown status	NCT00104676	Phase 3	cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3	Combination Chemotherapy in Treating Men With Germ Cell Cancer	Unknown status	NCT00003643	Phase 2, Phase 3	cisplatin;etoposide;paclitaxel
4	Safety and Efficacy of Antiadhesive Barrier GUARDIX-FL for Women After Laparoscopic Cystectomy	Unknown status	NCT02097446	Phase 3
5	Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors	Unknown status	NCT00274950	Phase 3	carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
6	Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors	Completed	NCT00053352	Phase 3	cisplatin;etoposide
7	Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors	Completed	NCT00002596	Phase 3	carboplatin;cisplatin;cyclophosphamide;etoposide
8	Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation	Completed	NCT00004230	Phase 3	captopril;cyclophosphamide
9	Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation	Completed	NCT00014391	Phase 3	ribavirin
10	Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation	Completed	NCT00003883	Phase 3	fluconazole;itraconazole
11	Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment	Completed	NCT00008359	Phase 3	caspofungin acetate;liposomal amphotericin B
12	Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients	Completed	NCT00003938	Phase 3	liposomal amphotericin B
13	Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer	Completed	NCT00003941	Phase 3	cisplatin;etoposide;ifosfamide
14	Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy	Completed	NCT00716976	Phase 3	sodium thiosulfate
15	Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy	Completed	NCT01346267	Phase 3
16	Single-port LC Might be Preferable for Managing Ovarian Dermoid Cyst.	Completed	NCT02009228	Phase 3
17	Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors	Recruiting	NCT03067181	Phase 3	Bleomycin;Carboplatin;Cisplatin;Etoposide
18	Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors	Recruiting	NCT02375204	Phase 3	paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
19	Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor	Active, not recruiting	NCT00085202	Phase 3	cisplatin;cyclophosphamide;vincristine
20	Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors	Terminated	NCT00072215	Phase 3	cisplatin;ifosfamide;paclitaxel;vinblastine
21	PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER	Unknown status	NCT01037790	Phase 2	PD-0332991
22	High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy	Unknown status	NCT01172912	Phase 2	carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
23	Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors	Unknown status	NCT00551122	Phase 1, Phase 2	cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
24	A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression	Completed	NCT02300987	Phase 2	LEE011;LEE011 Placebo
25	Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors	Completed	NCT00453232	Phase 2	cisplatin;etoposide
26	Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors	Completed	NCT00301782	Phase 2	carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
27	Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin	Completed	NCT00423852	Phase 1, Phase 2	carboplatin;ifosfamide;paclitaxel
28	Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment	Completed	NCT00453310	Phase 2	sunitinib malate
29	Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors	Completed	NCT00470366	Phase 2	cisplatin;ifosfamide;paclitaxel
30	Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer	Completed	NCT00002931	Phase 2	carboplatin;etoposide;ifosfamide;paclitaxel
31	Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment	Completed	NCT00091182	Phase 2	oxaliplatin
32	Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors	Completed	NCT00002489	Phase 2	carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
33	Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation	Completed	NCT00002673	Phase 2
34	Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation	Completed	NCT00003887	Phase 2
35	Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon	Completed	NCT00010283	Phase 1, Phase 2	beclomethasone dipropionate
36	Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors	Completed	NCT00004157	Phase 2
37	Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer	Completed	NCT00003408	Phase 2
38	Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors	Completed	NCT00070096	Phase 2	ixabepilone
39	Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer	Completed	NCT00004077	Phase 2	cisplatin;ifosfamide;paclitaxel
40	Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors	Completed	NCT00047320	Phase 2	carboplatin;etoposide;ifosfamide;thiotepa
41	Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors	Completed	NCT00002472	Phase 2	cisplatin;etoposide
42	Combination Chemotherapy Plus Amifostine in Treating Children With Malignant Germ Cell Tumors	Completed	NCT00003811	Phase 2	amifostine trihydrate;cisplatin;etoposide
43	High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors	Completed	NCT00003173	Phase 2	thiotepa
44	Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors	Completed	NCT00024258	Phase 2	arsenic trioxide
45	Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors	Completed	NCT00005955	Phase 2	temozolomide
46	Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor	Completed	NCT00047177	Phase 2	Oxaliplatin
47	Contribution of the Imaging to the Expression of intégrines αvβ3 for the Characterization of Residual Masses of Non-seminoma Tumors at the End of Chemotherapy	Recruiting	NCT02317393	Phase 2
48	Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors	Recruiting	NCT00432094	Phase 2	carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
49	Nivolumab and Ipilimumab in Treating Patients With Rare Tumors	Recruiting	NCT02834013	Phase 2
50	Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors	Recruiting	NCT02114229	Phase 2	alisertib;methotrexate;cisplatin;carboplatin;cyclophosphamide;etoposide;topotecan;vincristine

Search NIH Clinical Center for Teratoma

Cochrane evidence based reviews: teratoma

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Genetic Tests for Teratoma

Genetic tests related to Teratoma:

#	Genetic test	Affiliating Genes
1	Teratoma ²⁹

Sources

Anatomical Context for Teratoma

MalaCards organs/tissues related to Teratoma:

⁴¹

Ovary, Testis, Bone, Thyroid, Brain, Bone Marrow, Pineal

Sources

Publications for Teratoma

Articles related to Teratoma:

(show top 50) (show all 2635)

#	Title	Authors	Year
1	Erratum: Pashankar F, Hale JP, Dang H, et al. Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative. Cancer. 2016;122:230-237. ( 29509324 )		2018
2	True Ectopic Ovary with Mature Cystic Teratoma. ( 29684524 )	Lee C.Y....Wang C.J.	2018
3	High Tumor Volume to Fetal Weight Ratio Is Associated with Worse Fetal Outcomes and Increased Maternal Risk in Fetuses with Sacrococcygeal Teratoma. ( 29495013 )	Gebb J.S....Moldenhauer J.S.	2018
4	A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type <i>C. elegans</i>. ( 29928508 )	Wang H....Gems D.	2018
5	Cerebellar Differentiation in Ovarian Teratoma: A Report of 6 Cases. ( 29889717 )	Stewart C.J.R....Crook M.L.	2018
6	Metastatic mediastinal mature teratoma with malignant transformation in a young man with an adenocarcinoma in a Klinefelter's syndrome: Case report and review of the literature. ( 29673950 )	Le FA"vre C....NoAl G.	2018
7	Comparison of Teratoma Formation between Embryonic Stem Cells and Parthenogenetic Embryonic Stem Cells by Molecular Imaging. ( 29765423 )	Tao H....Li Z.	2018
8	Massive fetal cervical teratoma managed with the ex utero intrapartum treatment (EXIT) procedure. ( 29904479 )	Olivares E....Fong V.	2018
9	Testicular Yolk Sac Tumor and Mature Teratoma: Synchronous Bilateral Occurrence in an Infant. ( 29608939 )	Dong S....Wang S.	2018
10	Chondroid nodule in the female peritoneum arises from normal tissue and not from teratoma or conception product. ( 29368082 )	Franceschi T....Devouassoux-Shisheboran M.	2018
11	Thymic teratoma presenting as non-immune hydrops fetalis. ( 29515979 )	Hamza A....Higgins M.J.	2018
12	Orbital immature teratoma: A rare entity with diagnostic challenges. ( 29755277 )	Alkatan H.M....Al-Faky Y.H.	2018
13	Gliomatosis peritonei with <sup>18</sup>F-fluorodeoxyglucose accumulation and contrast enhancement secondary to immature teratoma: A case report. ( 29977538 )	Ohara T....Suginami K.	2018
14	Growing Teratoma Syndrome of Testicular Origin. ( 29807046 )	Nassiri N....Daneshmand S.	2018
15	Mature Cystic Teratoma Hiding in the Retroperitoneum of an Adult. ( 29670788 )	Singh Y....Arra A.	2018
16	Mature cystic teratoma of the pancreas with 30 years of clinical course: A case report. ( 29642205 )	Li Z....Gong S.	2018
17	Extraspinal sacrococcygeal ependymoma masquerading as sacrococcygeal teratoma in the pediatric patient. ( 29138922 )	Amin R....Siddiqui S.	2018
18	Nephroblastoma Arising in a Primary Testicular Teratoma in a Nonatrophic Testis of a 50-Year-Old Man. ( 29309092 )	Kromka J.J....Hale N.	2018
19	Diagnosis and Surgical Management of Congenital Intranasal Teratoma in a Newborn: A Rare Case Report. ( 29850332 )	Yeo W.X....Tan K.K.	2018
20	Epignathus (Palatal teratoma):A case report. ( 29607476 )	Nuamah I.K....Brown E.	2018
21	Teratoma as unusual cause of chest pain, hemoptysis and dyspnea in a young patient. ( 29321967 )	Hammen I....Lal Yadav A.	2018
22	Klinefelter's syndrome with lupus encephalitis and retroperitoneal teratoma. ( 29759049 )	Wq C.N....Ym K.	2018
23	Devil within: an incidental and rare finding of an extragonandal retroperitoneal germ cell teratoma carcinoid tumour. ( 29903775 )	O'Mara N....Cross K.S.	2018
24	Mature teratoma of the bladder in adolescence: a case report and literature review. ( 29951451 )	Prihadi J.C....Kusumajaya C.	2018
25	Failure to improve after ovarian resection could be a marker of recurrent ovarian teratoma in anti-NMDAR encephalitis: a case report. ( 29403279 )	Uchida Y....Matsukawa N.	2018
26	3D-printing aided resection of intratracheal adenoid cystic carcinoma and mediastinal mature cystic teratoma in a 26-year-old female: a case report. ( 29607203 )	Lu D....Cai K.	2018
27	Curious case of a black pleural effusion: Mediastinal teratoma presenting as massive pleural effusion. ( 29319045 )	Mitra S....Das A.K.	2018
28	Long-Term Outcome of Sacrococcygeal Teratoma: A Controlled Cohort Study of Urinary Tract and Bowel Dysfunction and Predictors of Poor Outcome. ( 29656864 )	Hambraeus M....BAPrjesson A.	2018
29	Muscling in on the Awesome Proliferative Power of the Terrible Teratoma. ( 29979984 )	Cutler A.A....Olwin B.B.	2018
30	Dnd1-mediated epigenetic control of teratoma formation in mouse. ( 29378702 )	Gu W....Matsui Y.	2018
31	Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids. ( 29455317 )	Kato N....Kurose A.	2018
32	Radiological-pathological correlation of malignant teratoma with liposarcomatous transformation: Proven by repeated transthoracic needle biopsy. ( 29106050 )	Lee H.J....Choi Y.D.	2018
33	Effects of mature cystic teratoma on reproductive health and malignant transformation: A retrospective analysis of 80 cases. ( 29755032 )	Kurt S....SaygA+lA+ U.	2018
34	The incidence of associated abnormalities in patients with sacrococcygeal teratoma. ( 29453131 )	Kremer M.E.B....van Heurn L.W.E.	2018
35	Rare case of squamous cell carcinoma arising in a recurrent ovarian mature cystic teratoma of a young woman: A case report and review of the literature. ( 29768376 )	FENG X....Xu L.	2018
36	Surgical management for a huge presacral teratoma and a meningocele in an adult with Currarino triad: a case report. ( 29352751 )	Emoto S....Nozawa H.	2018
37	Bilateral ovarian angiosarcoma arising from the mature cystic teratomas - A case report and review of the literature. ( 29227858 )	Kudela E....Danko J.	2018
38	Squamous Cell Carcinoma Arising in Mature Teratoma of the Ovary Masquerading as Abdominal Tuberculosis. ( 29628730 )	Indulkar S.T....Khade A.L.	2018
39	High-dose Chemotherapy is Efficacious and Well Tolerated in a Toddler With Aicardi Syndrome and Malignant Sacrococcygeal Teratoma. ( 29420371 )	Wharton J.D....Katzenstein H.M.	2018
40	Early treatment of intrapericardial teratoma: a case presentation and systematic literature review. ( 29320914 )	Cavalcante C.T.M.B....Castello Branco K.M.	2018
41	Teratoma-negative anti-NMDA receptor encephalitis presenting with a single generalized tonic-clonic seizure. ( 29977791 )	Ng A.C....Mirsattari S.M.	2018
42	Immature ovarian teratoma with gliomatosis peritonei with adenocarcinomatous differentiation in one of the lymph node's metastasis. ( 29523036 )	Rajpoot J....Dhawan I.	2018
43	Successful Treatment of Growing Teratoma Syndrome of the Lung by Surgical Resection: A Case Report and Literature Review. ( 29715149 )	Tanaka K....Maehara Y.	2018
44	Extensive spinal epidural immature teratoma in an infant: case report. ( 29979131 )	Yoshioka F....Abe T.	2018
45	Management of patients with metastatic teratoma with malignant somatic transformation. ( 29939859 )	Speir R....Masterson T.A.	2018
46	Teratoma Arising from Hepato Duodenal Ligament in the Newborn with Transection of Portal Vein, Hepatic Artery and Common Bile Duct: A Surgical Challenge. ( 29386766 )	Ravikumar V.R....Maniam R.	2018
47	Monsters in the uterus: teratoma-like tumors in senescent <i>C. elegans</i> result from a parthenogenetic quasi-program. ( 29923830 )	Wang H....Gems D.	2018
48	Fertility-sparing surgery of malignant transformation arising from mature cystic teratoma of the ovary. ( 29938006 )	Yoshikawa N....Kajiyama H.	2018
49	Mature Testicular Teratoma with a Focus of Embryonal Carcinoma: A Case Report and Review of Literature. ( 29770282 )	Chowdhury W....Rahim M.	2018
50	Ovarian teratoma associated Anti-N-methyl-D-aspartate receptor encephalitis: a difficult diagnosis with a favorable prognosis. ( 29780755 )	Mitra A.D....Afify A.	2018

Sources

Genes for Teratoma

Genes related to Teratoma (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	AFP	Alpha Fetoprotein	Protein Coding	44.62	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Summaries (show sections)	10386812 19493258 9258169 (more) 11745252 7685750 2162137 7543786 8976653 16896894 1696873 18525461 19156903 16503489 9354734 19453084 15567952 7537801 17350873 15272600 15218952 19142973 15895292 15613854 15802029 9648599 8934053 20088167 10427494 9202859 1704432 19785009 19198853 9021828 9440752
2	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	36.06	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	7514496 19912360 18057715
3	POU5F1	POU Class 5 Homeobox 1	Protein Coding	34.89	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	18439155 19826408 16494961 (more) 12161760 16978057 17535850 18062871 18393636
4	MNX1	Motor Neuron And Pancreas Homeobox 1	Protein Coding	31.36	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	14663834
5	KRT7	Keratin 7	Protein Coding	28.72	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19577382
6	ENO2	Enolase 2	Protein Coding	27.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	2024455 8938952
7	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	27.04	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9524573 1656435
8	NKX2-1	NK2 Homeobox 1	Protein Coding	25.35	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	18628097 16512597
9	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	25.34	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1680200 9535605 15247758
10	SOX2	SRY-Box 2	Protein Coding	24.68	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	17464316
11	GRN	Granulin Precursor	Protein Coding	23.21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	10760271 10066447
12	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	22.76	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9021828 10743710 15272600 (more) 17350873 9648599 1691781
13	CDX2	Caudal Type Homeobox 2	Protein Coding	22.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	DMRT1	Doublesex And Mab-3 Related Transcription Factor 1	Protein Coding	22.64	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
15	SYP	Synaptophysin	Protein Coding	22.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	TP53	Tumor Protein P53	Protein Coding	22.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	ACTC1	Actin, Alpha, Cardiac Muscle 1	Protein Coding	22.33	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	20363201
18	NES	Nestin	Protein Coding	22.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	15127288 18611917
19	CD99	CD99 Molecule (Xg Blood Group)	Protein Coding	14.93	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11598856

Sources

Variations for Teratoma

ClinVar genetic disease variations for Teratoma:

⁶

#	Gene	Variation	Type	Significance	Assembly	Location
1	CTNNB1	NM_001098209.1(CTNNB1): c.1876G> T (p.Glu626Ter)	single nucleotide variant	Likely pathogenic	GRCh37	Chromosome 3, 41277912: 41277912
2	CTNNB1	NM_001098209.1(CTNNB1): c.1876G> T (p.Glu626Ter)	single nucleotide variant	Likely pathogenic	GRCh38	Chromosome 3, 41236421: 41236421
3	SETBP1	NM_015559.2(SETBP1): c.2614G> A (p.Gly872Arg)	single nucleotide variant	Likely pathogenic	GRCh38	Chromosome 18, 44951954: 44951954
4	SETBP1	NM_015559.2(SETBP1): c.2614G> A (p.Gly872Arg)	single nucleotide variant	Likely pathogenic	GRCh37	Chromosome 18, 42531919: 42531919

Sources

Expression for Teratoma

Search GEO for disease gene expression data for Teratoma.

Sources

Pathways for Teratoma

Pathways related to Teratoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Wnt / Hedgehog / Notch ⁴	11.93	AFP CDX2 POU5F1 SOX2
2	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁶ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁶ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁶ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁶ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁶	11.6	CGA CGB3 KIT
3	Glucocorticoid receptor regulatory network ¹	11.52	AFP CGA TP53
4	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.48	AFP CDX2 NES POU5F1 SOX2
5	Preimplantation Embryo ¹	11.34	CDX2 NKX2-1 POU5F1 SOX2
6	Cardiac Progenitor Differentiation ¹	11.18	ACTC1 KIT POU5F1 SOX2
7	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	10.92	GFAP MNX1 NES SOX2 SYP
8	Oct4 in Mammalian ESC Pluripotency ⁶⁴	10.73	CDX2 POU5F1 SOX2
9	Human Early Embryo Development ⁶⁴ Show member pathways POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation ⁶⁶	10.4	POU5F1 SOX2

Sources

GO Terms for Teratoma

Biological processes related to Teratoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	multicellular organism development	GO:0007275	9.87	CDX2 DMRT1 KIT NES POU5F1 SOX2
2	negative regulation of transcription by RNA polymerase II	GO:0000122	9.73	CDX2 DMRT1 NKX2-1 POU5F1 SOX2 TP53
3	response to wounding	GO:0009611	9.58	GFAP POU5F1 SOX2
4	positive regulation of gene expression	GO:0010628	9.55	ACTC1 KIT NKX2-1 POU5F1 TP53
5	germ cell migration	GO:0008354	9.37	DMRT1 KIT
6	endodermal cell fate specification	GO:0001714	8.96	POU5F1 SOX2
7	somatic stem cell population maintenance	GO:0035019	8.92	CDX2 KIT POU5F1 SOX2

Molecular functions related to Teratoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA binding transcription factor activity	GO:0003700	9.5	CDX2 DMRT1 MNX1 NKX2-1 POU5F1 SOX2
2	sequence-specific DNA binding	GO:0043565	9.1	CDX2 DMRT1 MNX1 NKX2-1 POU5F1 SOX2

Sources

Sources for Teratoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia