MCID: TRT010
MIFTS: 53

Teratoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Teratoma

MalaCards integrated aliases for Teratoma:

Name: Teratoma 12 76 29 55 6 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3307
MeSH 44 D013724
NCIt 50 C3403
SNOMED-CT 68 55818009
UMLS 73 C0039538

Summaries for Teratoma

Disease Ontology : 12 A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers.

MalaCards based summary : Teratoma is related to sacrococcygeal teratoma and mature teratoma. An important gene associated with Teratoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Cytoskeleton remodeling Neurofilaments. The drugs Carboplatin and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 A teratoma is a tumor made up of several different types of tissue, such as hair, muscle, or bone. They... more...

Related Diseases for Teratoma

Diseases in the Teratoma family:

Malignant Teratoma Adult Teratoma
Intermediate Malignant Teratoma

Diseases related to Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 666)
# Related Disease Score Top Affiliating Genes
1 sacrococcygeal teratoma 34.1 AFP CGA MNX1
2 mature teratoma 33.8 AFP POU5F1 TP53
3 ovarian germ cell teratoma 33.6 KRT7 NKX2-1
4 malignant teratoma 33.6 AFP ENO2 POU5F1 SYP TP53
5 cystic teratoma 33.2 CDX2 ENO2 GFAP KRT7 NKX2-1 SYP
6 dermoid cyst 33.0 KIT KRT7 MNX1
7 testicular germ cell tumor 32.9 AFP CGB3 DMRT1 KIT TP53
8 polyembryoma 32.4 AFP CGA
9 mixed germ cell tumor 30.4 AFP CGA CGB3 KIT
10 testicular cancer 30.3 AFP CGA CGB3
11 pseudomyxoma peritonei 30.3 CDX2 KRT7 TP53
12 mucinous adenocarcinoma 30.3 CDX2 KRT7 NKX2-1
13 hepatoblastoma 30.2 AFP KRT7 TP53
14 oligodendroglioma 30.1 ENO2 GFAP SYP TP53
15 seminoma 30.0 AFP CGA CGB3 ENO2 KIT POU5F1
16 dysgerminoma 30.0 AFP ENO2 KIT KRT7
17 testicular seminoma 30.0 AFP CGA CGB3
18 carcinosarcoma 29.9 ACTC1 KIT KRT7 TP53
19 ganglioneuroma 29.9 ENO2 GFAP SYP
20 ovarian germ cell cancer 29.9 AFP KRT7 NKX2-1
21 renal cell carcinoma, papillary, 1 29.9 KIT KRT7 TP53
22 embryonal testis carcinoma 29.9 AFP POU5F1
23 embryonal carcinoma 29.9 AFP KIT NES POU5F1 SOX2
24 hemangioma 29.8 ACTC1 ENO2 NKX2-1 SYP
25 adenomatoid tumor 29.8 AFP KRT7 NKX2-1
26 papilloma of choroid plexus 29.8 GFAP SYP TP53
27 ependymoma 29.8 ENO2 GFAP NES SYP
28 adenosquamous carcinoma 29.8 KIT KRT7 NKX2-1 TP53
29 testicular yolk sac tumor 29.8 AFP CDX2 POU5F1
30 papillary adenoma 29.7 KRT7 NKX2-1
31 chromosomal triplication 29.7 AFP CGA CGB3
32 hydrocephalus 29.6 ENO2 GFAP NES SYP TP53
33 neuroendocrine tumor 29.6 ENO2 KRT7 NKX2-1 SYP
34 inflammatory myofibroblastic tumor 29.6 ACTC1 KIT TP53
35 small cell carcinoma 29.6 ENO2 KIT KRT7 NKX2-1 SYP TP53
36 endocervical adenocarcinoma 29.6 CDX2 KRT7 TP53
37 central neurocytoma 29.5 ENO2 GFAP NES SYP
38 germ cell cancer 29.5 AFP CGA DMRT1 KIT POU5F1 SOX2
39 adenoid cystic carcinoma 29.5 ACTC1 KIT KRT7 TP53
40 large cell neuroendocrine carcinoma 29.4 ENO2 KIT KRT7 NKX2-1 SYP
41 horseshoe kidney 29.4 ACTC1 CDX2 ENO2 KRT7 NKX2-1 SYP
42 medullomyoblastoma 29.4 ENO2 GFAP SYP TP53
43 cavernous hemangioma 29.4 KIT KRT7 NKX2-1 SYP
44 ovarian embryonal carcinoma 29.4 AFP POU5F1 SOX2
45 wilms tumor 1 29.4 ENO2 KRT7 NKX2-1 TP53
46 leiomyosarcoma 29.3 ACTC1 ENO2 KIT TP53
47 glomus tumor 29.3 ACTC1 ENO2 SYP TP53
48 gliosarcoma 29.1 ACTC1 ENO2 GFAP NES TP53
49 medulloblastoma 28.4 ACTC1 ENO2 GFAP NES SOX2 SYP
50 immature teratoma of ovary 12.4

Graphical network of the top 20 diseases related to Teratoma:



Diseases related to Teratoma

Symptoms & Phenotypes for Teratoma

GenomeRNAi Phenotypes related to Teratoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.47 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.47 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.47 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.47 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.47 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.47 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.47 AFP KRT7 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 AFP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.47 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.47 KRT7 POU5F1

MGI Mouse Phenotypes related to Teratoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.23 ACTC1 CDX2 ENO2 GFAP GRN KIT
2 behavior/neurological MP:0005386 10.22 AFP ENO2 GFAP GRN KIT MNX1
3 growth/size/body region MP:0005378 10.11 ACTC1 CDX2 CGA ENO2 GFAP GRN
4 endocrine/exocrine gland MP:0005379 10.1 AFP CDX2 CGA DMRT1 KIT MNX1
5 homeostasis/metabolism MP:0005376 10.1 ACTC1 AFP CDX2 CGA GFAP GRN
6 digestive/alimentary MP:0005381 10.03 CDX2 GFAP KIT MNX1 NKX2-1 POU5F1
7 nervous system MP:0003631 9.9 CGA ENO2 GFAP GRN KIT MNX1
8 neoplasm MP:0002006 9.73 AFP CDX2 KIT NKX2-1 SOX2 TP53
9 normal MP:0002873 9.65 ACTC1 CDX2 GFAP KIT MNX1 NKX2-1
10 reproductive system MP:0005389 9.32 AFP CDX2 CGA DMRT1 GRN KIT

Drugs & Therapeutics for Teratoma

Drugs for Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 170)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
2
Mechlorethamine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 51-75-2 4033
3
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 2767 441203 84093
4
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
5
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
6
Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1 0
7 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
13
Bleomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 11056-06-7 5360373
14
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
15
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 135968-09-1
16
Vinblastine Approved Phase 3 865-21-4 241903 13342
17
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
19
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
20
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 3375-50-6 598
21
Captopril Approved Phase 3 62571-86-2 44093
22
Ribavirin Approved Phase 3 36791-04-5 37542
23
Palivizumab Approved, Investigational Phase 3 188039-54-5
24
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
25
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
26
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
27
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
28
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
29
Ondansetron Approved Phase 3 99614-02-5 4595
30
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
31
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 57-22-7, 2068-78-2 5978
32
Promethazine Approved, Investigational Phase 3 60-87-7 4927
33
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
34 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
35 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1,Not Applicable
36 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Not Applicable
37 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
38 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
39 Immunologic Factors Phase 3,Phase 1,Phase 2,Not Applicable
40 Immunosuppressive Agents Phase 3,Phase 1,Phase 2,Not Applicable
41 Antimetabolites Phase 3,Phase 1,Phase 2
42 Anti-Infective Agents Phase 3,Phase 1,Phase 2
43 Antiviral Agents Phase 3,Phase 1,Phase 2
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
45 Hormones Phase 3,Phase 2,Phase 1
46 Hormone Antagonists Phase 3,Phase 2,Phase 1
47 Liver Extracts Phase 3,Phase 2,Phase 1
48 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
49 Antiemetics Phase 3,Phase 2,Phase 1
50 Autonomic Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 103)
# Name Status NCT ID Phase Drugs
1 Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors Unknown status NCT01424839 Phase 4 Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
4 Safety and Efficacy of Antiadhesive Barrier GUARDIX-FL for Women After Laparoscopic Cystectomy Unknown status NCT02097446 Phase 3
5 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
6 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
7 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
8 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
9 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
10 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
11 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
12 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
13 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
14 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
15 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
16 Single-port LC Might be Preferable for Managing Ovarian Dermoid Cyst. Completed NCT02009228 Phase 3
17 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
18 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
19 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Active, not recruiting NCT00085202 Phase 3 cisplatin;cyclophosphamide;vincristine
20 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
21 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
22 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
23 A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression Completed NCT02300987 Phase 2 LEE011;LEE011 Placebo
24 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
25 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
26 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
27 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
28 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
29 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
30 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
31 Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
32 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
33 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
34 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
35 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
36 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
37 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
38 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
39 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
40 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
41 Combination Chemotherapy Plus Amifostine in Treating Children With Malignant Germ Cell Tumors Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
42 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
43 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
44 Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors Completed NCT00005955 Phase 2 temozolomide
45 Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Completed NCT00047177 Phase 2 Oxaliplatin
46 Contribution of the Imaging to the Expression of intégrines αvβ3 for the Characterization of Residual Masses of Non-seminoma Tumors at the End of Chemotherapy Recruiting NCT02317393 Phase 2
47 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
48 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
49 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
50 Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors Recruiting NCT02114229 Phase 2 alisertib;methotrexate;cisplatin;carboplatin;cyclophosphamide;etoposide;topotecan;vincristine

Search NIH Clinical Center for Teratoma

Cochrane evidence based reviews: teratoma

Genetic Tests for Teratoma

Genetic tests related to Teratoma:

# Genetic test Affiliating Genes
1 Teratoma 29

Anatomical Context for Teratoma

MalaCards organs/tissues related to Teratoma:

41
Ovary, Testis, Thyroid, Bone, Pineal, Brain, Liver

Publications for Teratoma

Articles related to Teratoma:

(show top 50) (show all 3143)
# Title Authors Year
1
Squamous cell carcinoma arising in a partially ruptured giant mature cystic teratoma: A case report. ( 30386447 )
2019
2
Ocular structures in a mature ovarian teratoma. ( 30505981 )
2019
3
True Ectopic Ovary with Mature Cystic Teratoma. ( 29684524 )
2018
4
High Tumor Volume to Fetal Weight Ratio Is Associated with Worse Fetal Outcomes and Increased Maternal Risk in Fetuses with Sacrococcygeal Teratoma. ( 29495013 )
2018
5
A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type <i>C. elegans</i>. ( 29928508 )
2018
6
Cerebellar Differentiation in Ovarian Teratoma: A Report of 6 Cases. ( 29889717 )
2018
7
Metastatic mediastinal mature teratoma with malignant transformation in a young man with an adenocarcinoma in a Klinefelter's syndrome: Case report and review of the literature. ( 29673950 )
2018
8
Comparison of Teratoma Formation between Embryonic Stem Cells and Parthenogenetic Embryonic Stem Cells by Molecular Imaging. ( 29765423 )
2018
9
Massive fetal cervical teratoma managed with the ex utero intrapartum treatment (EXIT) procedure. ( 29904479 )
2018
10
Testicular Yolk Sac Tumor and Mature Teratoma: Synchronous Bilateral Occurrence in an Infant. ( 29608939 )
2018
11
Chondroid nodule in the female peritoneum arises from normal tissue and not from teratoma or conception product. ( 29368082 )
2018
12
Thymic teratoma presenting as non-immune hydrops fetalis. ( 29515979 )
2018
13
Orbital immature teratoma: A rare entity with diagnostic challenges. ( 29755277 )
2018
14
Gliomatosis peritonei with <sup>18</sup>F-fluorodeoxyglucose accumulation and contrast enhancement secondary to immature teratoma: A case report. ( 29977538 )
2018
15
Growing Teratoma Syndrome of Testicular Origin. ( 29807046 )
2018
16
Mature Cystic Teratoma Hiding in the Retroperitoneum of an Adult. ( 29670788 )
2018
17
Mature cystic teratoma of the pancreas with 30 years of clinical course: A case report. ( 29642205 )
2018
18
Extraspinal sacrococcygeal ependymoma masquerading as sacrococcygeal teratoma in the pediatric patient. ( 29138922 )
2018
19
Nephroblastoma Arising in a Primary Testicular Teratoma in a Nonatrophic Testis of a 50-Year-Old Man. ( 29309092 )
2018
20
Diagnosis and Surgical Management of Congenital Intranasal Teratoma in a Newborn: A Rare Case Report. ( 29850332 )
2018
21
Epignathus (Palatal teratoma):A case report. ( 29607476 )
2018
22
Teratoma as unusual cause of chest pain, hemoptysis and dyspnea in a young patient. ( 29321967 )
2018
23
Klinefelter's syndrome with lupus encephalitis and retroperitoneal teratoma. ( 29759049 )
2018
24
Devil within: an incidental and rare finding of an extragonandal retroperitoneal germ cell teratoma carcinoid tumour. ( 29903775 )
2018
25
Mature teratoma of the bladder in adolescence: a case report and literature review. ( 29951451 )
2018
26
Failure to improve after ovarian resection could be a marker of recurrent ovarian teratoma in anti-NMDAR encephalitis: a case report. ( 29403279 )
2018
27
3D-printing aided resection of intratracheal adenoid cystic carcinoma and mediastinal mature cystic teratoma in a 26-year-old female: a case report. ( 29607203 )
2018
28
Curious case of a black pleural effusion: Mediastinal teratoma presenting as massive pleural effusion. ( 29319045 )
2018
29
Long-Term Outcome of Sacrococcygeal Teratoma: A Controlled Cohort Study of Urinary Tract and Bowel Dysfunction and Predictors of Poor Outcome. ( 29656864 )
2018
30
Muscling in on the Awesome Proliferative Power of the Terrible Teratoma. ( 29979984 )
2018
31
Dnd1-mediated epigenetic control of teratoma formation in mouse. ( 29378702 )
2018
32
Radiological-pathological correlation of malignant teratoma with liposarcomatous transformation: Proven by repeated transthoracic needle biopsy. ( 29106050 )
2018
33
Effects of mature cystic teratoma on reproductive health and malignant transformation: A retrospective analysis of 80 cases. ( 29755032 )
2018
34
The incidence of associated abnormalities in patients with sacrococcygeal teratoma. ( 29453131 )
2018
35
Rare case of squamous cell carcinoma arising in a recurrent ovarian mature cystic teratoma of a young woman: A case report and review of the literature. ( 29768376 )
2018
36
Surgical management for a huge presacral teratoma and a meningocele in an adult with Currarino triad: a case report. ( 29352751 )
2018
37
Squamous Cell Carcinoma Arising in Mature Teratoma of the Ovary Masquerading as Abdominal Tuberculosis. ( 29628730 )
2018
38
High-dose Chemotherapy is Efficacious and Well Tolerated in a Toddler With Aicardi Syndrome and Malignant Sacrococcygeal Teratoma. ( 29420371 )
2018
39
Early treatment of intrapericardial teratoma: a case presentation and systematic literature review. ( 29320914 )
2018
40
Teratoma-negative anti-NMDA receptor encephalitis presenting with a single generalized tonic-clonic seizure. ( 29977791 )
2018
41
Immature ovarian teratoma with gliomatosis peritonei with adenocarcinomatous differentiation in one of the lymph node's metastasis. ( 29523036 )
2018
42
Successful Treatment of Growing Teratoma Syndrome of the Lung by Surgical Resection: A Case Report and Literature Review. ( 29715149 )
2018
43
Extensive spinal epidural immature teratoma in an infant: case report. ( 29979131 )
2018
44
Management of patients with metastatic teratoma with malignant somatic transformation. ( 29939859 )
2018
45
Teratoma Arising from Hepato Duodenal Ligament in the Newborn with Transection of Portal Vein, Hepatic Artery and Common Bile Duct: A Surgical Challenge. ( 29386766 )
2018
46
Monsters in the uterus: teratoma-like tumors in senescent <i>C. elegans</i> result from a parthenogenetic quasi-program. ( 29923830 )
2018
47
Fertility-sparing surgery of malignant transformation arising from mature cystic teratoma of the ovary. ( 29938006 )
2018
48
Mature Testicular Teratoma with a Focus of Embryonal Carcinoma: A Case Report and Review of Literature. ( 29770282 )
2018
49
Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male. ( 30402315 )
2018
50
Development of angiosarcoma in a mediastinal non-seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy. ( 30407736 )
2018

Variations for Teratoma

ClinVar genetic disease variations for Teratoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CTNNB1 NM_001098209.1(CTNNB1): c.1876G> T (p.Glu626Ter) single nucleotide variant Likely pathogenic GRCh37 Chromosome 3, 41277912: 41277912
2 CTNNB1 NM_001098209.1(CTNNB1): c.1876G> T (p.Glu626Ter) single nucleotide variant Likely pathogenic GRCh38 Chromosome 3, 41236421: 41236421
3 SETBP1 NM_015559.2(SETBP1): c.2614G> A (p.Gly872Arg) single nucleotide variant Likely pathogenic GRCh38 Chromosome 18, 44951954: 44951954
4 SETBP1 NM_015559.2(SETBP1): c.2614G> A (p.Gly872Arg) single nucleotide variant Likely pathogenic GRCh37 Chromosome 18, 42531919: 42531919

Expression for Teratoma

Search GEO for disease gene expression data for Teratoma.

Pathways for Teratoma

Pathways related to Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.93 AFP CDX2 POU5F1 SOX2
2
Show member pathways
11.69 GFAP KRT7 NES
3
Show member pathways
11.6 CGA CGB3 KIT
4 11.52 AFP CGA TP53
5 11.48 AFP CDX2 NES POU5F1 SOX2
6 11.34 CDX2 NKX2-1 POU5F1 SOX2
7 11.18 ACTC1 KIT POU5F1 SOX2
8 10.92 GFAP MNX1 NES SOX2 SYP
9 10.73 CDX2 POU5F1 SOX2
10
Show member pathways
10.4 POU5F1 SOX2

GO Terms for Teratoma

Biological processes related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.73 CDX2 DMRT1 NKX2-1 POU5F1 SOX2 TP53
2 positive regulation of gene expression GO:0010628 9.55 ACTC1 KIT NKX2-1 POU5F1 TP53
3 response to wounding GO:0009611 9.54 GFAP POU5F1 SOX2
4 germ cell migration GO:0008354 9.32 DMRT1 KIT
5 endodermal cell fate specification GO:0001714 8.96 POU5F1 SOX2
6 somatic stem cell population maintenance GO:0035019 8.92 CDX2 KIT POU5F1 SOX2

Molecular functions related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.43 CDX2 DMRT1 MNX1 NKX2-1 POU5F1 SOX2
2 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.33 CDX2 NKX2-1 TP53
3 DNA-binding transcription factor activity GO:0003700 9.17 CDX2 DMRT1 MNX1 NKX2-1 POU5F1 SOX2

Sources for Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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