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MCID: TRT010
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Teratoma

Categories: Bone diseases, Cancer diseases, Reproductive diseases
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Aliases & Classifications for Teratoma

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MalaCards integrated aliases for Teratoma:

Name: Teratoma 11 75 53 5 43 14 71
Teratomas 14

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:3307
MeSH 43 D013724
NCIt 49 C3403
SNOMED-CT 68 36591000119102
UMLS 71 C0039538
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Summaries for Teratoma

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Disease Ontology: 11 A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers.

MalaCards based summary: Teratoma, also known as teratomas, is related to gastric teratoma and malignant gastric teratoma. An important gene associated with Teratoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Peptide hormone metabolism. The drugs Carboplatin and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and testis, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism

Wikipedia: 75 A teratoma is a tumor made up of several different types of tissue, such as hair, muscle, teeth, or... more...
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Related Diseases for Teratoma

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Diseases in the Teratoma family:

Benign Teratoma Malignant Teratoma
Adult Teratoma Intermediate Malignant Teratoma

Diseases related to Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1353)
# Related Disease Score Top Affiliating Genes
1 gastric teratoma 32.9 KIT AFP
2 malignant gastric teratoma 32.8 KIT AFP
3 adult teratoma 32.7 TP53 AFP
4 cystic teratoma 32.6 TP53 NKX2-1 MNX1 KRT7 ENO2 AFP
5 benign teratoma 32.6 TP53 NKX2-1 MNX1 KRT7 ENO2 AFP
6 mature teratoma of the ovary 32.5 ENO2 AFP
7 ovarian cystic teratoma 32.5 NKX2-1 AFP
8 pineal region teratoma 32.5 KIT ENO2 AFP
9 central nervous system immature teratoma 32.4 SOX2 GFAP
10 malignant teratoma 32.3 TP53 SOX2 POU5F1 MIR371A KIT GFAP
11 ovarian germ cell teratoma 32.2 NKX2-1 KRT7 AFP
12 mature teratoma 32.2 TP53 SOX2 POU5F1 MIR371A KRT7 KIT
13 endodermal sinus tumor 32.1 POU5F1 MIR371A KRT7 KIT CGB5 CGB3
14 mixed germ cell cancer 31.6 SOX2 POU5F1 KRT7 KIT ENO2 AFP
15 testicular cancer 31.3 TP53 POU5F1 MIR371A KIT CGB5 CGB3
16 carcinoid tumors, intestinal 31.2 NKX2-1 ENO2
17 choriocarcinoma 31.2 CGB7 CGB5 CGB3 CGA
18 appendix adenocarcinoma 31.2 TP53 KRT7
19 cystadenoma 31.1 KRT7 KIT AFP
20 cryptorchidism, unilateral or bilateral 31.1 POU5F1 KIT CGB5 CGA AFP
21 lipomatosis, multiple 31.0 TP53 KIT AFP
22 mediastinal cancer 31.0 NKX2-1 KRT7 KIT ENO2 AFP
23 cystadenocarcinoma 31.0 TP53 KRT7 ACTC1
24 ewing sarcoma 30.9 TP53 POU5F1 KIT ENO2 CD99
25 testicular germ cell cancer 30.9 TP53 POU5F1 MIR371A KIT AFP
26 obstructive hydrocephalus 30.9 GFAP ENO2 AFP
27 embryonal carcinoma 30.8 TP53 SOX2 POU5F1 KIT CGB5 CGB3
28 germ cell cancer 30.8 TP53 SOX2 POU5F1 MIR371A KIT ENO2
29 pineocytoma 30.8 GFAP ENO2
30 down syndrome 30.8 TP53 CGB7 CGB5 CGB3 CGA AFP
31 germinoma 30.8 POU5F1 MIR371A KIT CGB7 CGB5 CGB3
32 dysgerminoma 30.7 MIR371A KRT7 KIT ENO2 AFP
33 extragonadal germ cell cancer 30.7 CGB5 AFP
34 mucinous adenocarcinoma 30.7 TP53 NKX2-1 KRT7 CTNNB1
35 neural tube defects 30.7 TP53 MNX1 GFAP ENO2 CTNNB1 CGB7
36 ovarian germ cell cancer 30.7 POU5F1 NKX2-1 MIR371A KRT7 KIT AFP
37 ectopic pregnancy 30.7 MIR371A CGB7 CGB5 CGB3 CGA AFP
38 embryonal rhabdomyosarcoma 30.6 TP53 ENO2 CD99 ACTC1
39 papilloma of choroid plexus 30.6 TP53 KRT7 GFAP ENO2
40 pseudomyxoma peritonei 30.6 TP53 KRT7 CTNNB1
41 leiomyosarcoma 30.6 TP53 KIT ENO2 ACTC1
42 angiomyolipoma 30.6 TP53 KRT7 KIT AFP ACTC1
43 sarcoma 30.5 TP53 POU5F1 KIT ENO2 CTNNB1 ACTC1
44 lymphangioma 30.5 TP53 KRT7 CTNNB1 AFP ACTC1
45 rhabdomyosarcoma 30.5 TP53 KRT7 KIT GFAP ENO2 CTNNB1
46 ovarian benign neoplasm 30.5 TP53 KRT7 AFP
47 placental site trophoblastic tumor 30.5 CGB5 CGB3 CGA
48 trophoblastic neoplasm 30.5 MIR371A CGB5 CGA AFP
49 hydatidiform mole, recurrent, 1 30.5 CGB5 CGB3 CGA
50 carcinosarcoma 30.5 TP53 KRT7 KIT CTNNB1 ACTC1

Graphical network of the top 20 diseases related to Teratoma:



Diseases related to Teratoma
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Symptoms & Phenotypes for Teratoma

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GenomeRNAi Phenotypes related to Teratoma according to GeneCards Suite gene sharing:

25 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.58 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.58 POU5F1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.58 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.58 KRT7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.58 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-171 9.58 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.58 AFP KRT7 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-216 9.58 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.58 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.58 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.58 KRT7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.58 KRT7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.58 KRT7 POU5F1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.58 AFP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.58 KRT7

MGI Mouse Phenotypes related to Teratoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 ACTC1 AFP CGA CGB3 CGB5 CGB7
2 nervous system MP:0003631 10.21 ACTC1 CGA CTNNB1 ENO2 GFAP GRN
3 growth/size/body region MP:0005378 10.21 ACTC1 CGA CGB3 CGB5 CGB7 CTNNB1
4 normal MP:0002873 10.11 ACTC1 CTNNB1 GFAP KIT MNX1 NKX2-1
5 endocrine/exocrine gland MP:0005379 10.1 AFP CGA CGB3 CGB5 CGB7 CTNNB1
6 cellular MP:0005384 10.03 ACTC1 CGB3 CGB5 CGB7 CTNNB1 ENO2
7 digestive/alimentary MP:0005381 9.86 CTNNB1 GFAP KIT MNX1 NKX2-1 POU5F1
8 behavior/neurological MP:0005386 9.77 ACTC1 AFP CTNNB1 ENO2 GFAP GRN
9 reproductive system MP:0005389 9.4 AFP CGA CGB3 CGB5 CGB7 CTNNB1
Sources

Drugs & Therapeutics for Teratoma

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Drugs for Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 38904
2
Lenograstim Approved, Investigational Phase 3 135968-09-1
3
Coenzyme M Approved, Investigational Phase 3 3375-50-6 598 23662354
4
Picropodophyllin Approved, Investigational Phase 3 518-28-5, 477-47-4 10607 72435
5
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
6
Promethazine Approved, Investigational Phase 3 60-87-7 4927
7
Cisplatin Approved Phase 3 15663-27-1 2767 5702198 441203
8
Etoposide Approved Phase 3 33419-42-0 36462
9
Bleomycin Approved, Investigational Phase 3 9041-93-4, 11056-06-7 5360373
10
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
11
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 11947679 6857599
12 Immunologic Factors Phase 3
13 Adjuvants, Immunologic Phase 3
14 Keratolytic Agents Phase 3
15 Dermatologic Agents Phase 3
16 Histamine H2 Antagonists Phase 3
17
Etoposide phosphate Phase 3 16760419
18 Antimitotic Agents Phase 3
19 Tubulin Modulators Phase 3
20 Anti-Bacterial Agents Phase 3
21 Antibiotics, Antitubercular Phase 3
22 Albumin-Bound Paclitaxel Phase 3
23
Palbociclib Approved, Investigational Phase 2 571190-30-2 5330286
24
Sunitinib Approved, Investigational Phase 2 557795-19-4 5329102
25
Ipilimumab Approved Phase 2 477202-00-9
26
Levonorgestrel Approved, Investigational Phase 2 797-63-7 13109
27
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
28
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
29
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
30
Levoleucovorin Approved, Experimental, Investigational Phase 2 68538-85-2, 58-05-9, 73951-54-9 149436 6006
31
Nivolumab Approved Phase 2 946414-94-4
32
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60699 60700
33
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 4112 126941
34
Ifosfamide Approved Phase 2 3778-73-2 3690
35
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
36
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
37
Lysine Approved, Nutraceutical Phase 2 56-87-1 5962
38
Palifosfamide Investigational Phase 2 31645-39-3 100427
39 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
40 Protein Kinase Inhibitors Phase 2
41 Angiogenesis Inhibitors Phase 2
42 Immunoglobulins Phase 2
43 Immune Checkpoint Inhibitors Phase 2
44 Antibodies, Monoclonal Phase 2
45 Antibodies Phase 2
46 Antineoplastic Agents, Immunological Phase 2
47 Immunosuppressive Agents Phase 2
48 Protective Agents Phase 2
49 Folate Phase 2
50 Vitamin B9 Phase 2

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
3 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Carboplatin;Cisplatin;Etoposide
4 A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
5 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
6 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Completed NCT01037790 Phase 2 PD-0332991
7 A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression Completed NCT02300987 Phase 2 LEE011;LEE011 Placebo
8 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
9 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Completed NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
10 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
11 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
12 Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
13 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
14 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
15 A Phase II Study of Oxaliplatin in Children With Recurrent Solid Tumors Completed NCT00091182 Phase 2 oxaliplatin
16 A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular &Amp; Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor Recruiting NCT04684368 Phase 2 Carboplatin;Etoposide;Ifosfamide;Mesna;Thiotepa
17 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
18 Phase 2 Study of Alisertib as a Single Agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnosed AT/RT Recruiting NCT02114229 Phase 2 alisertib;methotrexate;cisplatin;carboplatin;cyclophosphamide;etoposide;topotecan;vincristine
19 Multicenter Single Arm Phase II Study of Single Agent Palifosfamide in Recurrent and Incurable Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
20 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
21 A Phase I Study of Sunitinib (SU11248), an Oral Multi-Targeted Tyrosine Kinase Inhibitor, in Children With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
22 A Phase I Study of Vorinostat and Bortezomib in Children With Refractory or Recurrent Solid Tumors, Including CNS Tumors and Lymphomas Completed NCT00994500 Phase 1 vorinostat;bortezomib
23 Phase I Feasibility Trial To Study The Safety Of Sealing Resected Pancreatic Surfaces After Partial Distal Pancreatectomy Using Laser Tissue Welding Completed NCT03147768 Phase 1
24 A Phase I Study of Pazopanib as a Single Agent for Children With Relapsed or Refractory Solid Tumors Completed NCT00929903 Phase 1 pazopanib hydrochloride
25 A Phase I Study of SAHA and Temozolomide in Children With Relapsed or Refractory Primary Brain or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
26 A Multi-Center Phase Ib Study of Oxaliplatin (NSC #266046) in Combination With Fluorouracil and Leucovorin in Pediatric Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
27 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
28 11C-Acetate PET/CT Non-FDG-Avid Tumors Unknown status NCT00687778
29 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355
30 Characterization of At-risk Population and Prognosis Factors for SACRO-coccygeal Teratoma in CURRARINO Syndrome. A Clinical, Molecular and Pathological Study. Completed NCT00780117
31 Improving Prenatal Parental Counseling in Cases of Sacrococcygeal Teratoma: a Multicenter Retrospective Study With Review of the Literature Completed NCT04623658
32 Case Report of a 39 Years Old Man That Has Been Cured by a Total Resection of a Anterior Mediastinum Teratoma. Completed NCT00836121
33 A Study of CT Scan Frequency in Patients With Stage I Testicular Teratoma Completed NCT00003420
34 Voiding Disorders in Children After Sacrococcygeal Teratoma Resection Completed NCT05182853
35 A Prospective Study of Cognitive Function During Chemotherapy for Front-Line Treatment of Ovarian, Primary Peritoneal or Fallopian Tube Cancer Completed NCT01080521
36 The Differences Between Gonadal and Extra-gonadal Malignant Teratomas in Both Genders and the Effects of Chemotherapy Completed NCT04555395
37 The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study Recruiting NCT02402244
38 Pediatric Germ Cell Tumors: Outcomes, Genomics and Epigenetics Recruiting NCT05564026
39 Computer Aided Diagnostic Tool on Computed Tomography Images for Diagnosis of Retroperitoneal Tumor in Children Recruiting NCT05179850
40 Computer Aided Tool for Diagnosis of Neck Masses in Children Recruiting NCT05187923
41 Rare Tumor Case Review Terminated NCT00229879

Search NIH Clinical Center for Teratoma

Cochrane evidence based reviews: teratoma

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Genetic Tests for Teratoma

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Anatomical Context for Teratoma

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Organs/tissues related to Teratoma:

MalaCards : Ovary, Bone, Testis, Lymph Node, Spinal Cord, Pineal, Bone Marrow
Sources

Publications for Teratoma

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Articles related to Teratoma:

(show top 50) (show all 15822)
# Title Authors PMID Year
1
Generation of induced pluripotent stem cells from newborn marmoset skin fibroblasts. 53 62
20363201 2010
2
Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells. 53 62
19785009 2010
3
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. 53 62
19826408 2009
4
Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours. 53 62
19912360 2009
5
Results of retroperitoneal lymph node dissection after chemotherapy in patients with pure seminoma in the orchidectomy specimen but elevated serum alpha-fetoprotein. 53 62
19493258 2009
6
Basic FGF and Activin/Nodal but not LIF signaling sustain undifferentiated status of rabbit embryonic stem cells. 53 62
19331817 2009
7
Progression from an immature teratoma with miliary gliomatosis peritonei to growing teratoma syndrome with nodular gliomatosis peritonei. 53 62
19453084 2009
8
Alpha-fetoprotein levels correlate with the pathologic grade and surgical outcomes of pediatric retroperitoneal teratomas. 53 62
19198853 2009
9
Yolk sac tumor but not seminoma or teratoma is associated with abnormal epigenetic reprogramming pathway and shows frequent hypermethylation of various tumor suppressor genes. 53 62
19245437 2009
10
Isolation of three stem cell lines from human sacrococcygeal teratomas. 53 62
19142973 2009
11
Long-term outcome for men with teratoma found at postchemotherapy retroperitoneal lymph node dissection. 53 62
19156903 2009
12
Pineal region tumors--neurosurgical review. 53 62
20088167 2009
13
Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature. 53 62
19577382 2009
14
Distinct GAGE and MAGE-A expression during early human development indicate specific roles in lineage differentiation. 53 62
18611917 2008
15
Neuron-like differentiation and selective ablation of undifferentiated embryonic stem cells containing suicide gene with Oct-4 promoter. 53 62
18393636 2008
16
The distinction of bronchogenic cyst from metastatic testicular teratoma: a light microscopic and immunohistochemical study. 53 62
18628097 2008
17
Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study. 53 62
18525461 2008
18
Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. 53 62
18439155 2008
19
Oncofetal protein glypican-3 distinguishes yolk sac tumor from clear cell carcinoma of the ovary. 53 62
18277882 2008
20
Comparative growth behaviour and characterization of stem cells from human Wharton's jelly. 53 62
18062871 2007
21
FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin. 53 62
17875810 2007
22
Analyses of novel prognostic factors in neuroblastoma patients. 53 62
18057715 2007
23
Expression of Sox2 in mature and immature teratomas of central nervous system. 53 62
17464316 2007
24
Regulated Nodal signaling promotes differentiation of the definitive endoderm and mesoderm from ES cells. 53 62
17535850 2007
25
[Malignant ovarian germ cell tumours: a trial of 36 cases]. 53 62
17350873 2007
26
Glypican 3: a novel marker in testicular germ cell tumors. 53 62
17122513 2006
27
Oncofetal protein glypican-3 in testicular germ-cell tumor. 53 62
16896894 2006
28
Characterization and gene expression profiling of five new human embryonic stem cell lines derived in Taiwan. 53 62
16978057 2006
29
Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma. 53 62
16718353 2006
30
Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression. 53 62
16596424 2006
31
TGF-beta2 allows pluripotent human embryonic stem cell proliferation on E6/E7 immortalized mouse embryonic fibroblasts. 53 62
16494961 2006
32
Pineal region teratoma with high serum and CSF alpha-fetoprotein levels. 53 62
16503489 2006
33
Malignant cervical teratoma: report of a case in a newborn. 53 62
15895292 2005
34
Transcription factor GATA-6 is expressed in malignant endoderm of pediatric yolk sac tumors and in teratomas. 53 62
16006960 2005
35
Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development. 53 62
15774903 2005
36
Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors. 53 62
16512597 2005
37
Interpretation of alpha-fetoprotein concentrations in cerebrospinal fluid of infants. 53 62
15802029 2005
38
Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. 53 62
15613854 2005
39
[The value of cytology in the diagnosis of extragonadal germ cell tumors]. 53 62
15567952 2004
40
Epidemiological and clinical behavior of prepubertal testicular tumors in Korea. 53 62
15247758 2004
41
[Clinical usefulness of circulating tumor markers]. 53 62
15272600 2004
42
Nestin, a neuroectodermal stem cell marker molecule, is expressed in Leydig cells of the human testis and in some specific cell types from human testicular tumours. 53 62
15127288 2004
43
Intracranial germ cell tumors: a single institution experience and review of the literature. 53 62
15218952 2004
44
Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. 53 62
14663834 2003
45
Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells. 53 62
12161760 2002
46
Apoptosis and proliferative activity in mature and immature teratomas of the mediastinum. 53 62
11745252 2001
47
Malignant teratoma of the thyroid with primitive neuroepithelial and mesenchymal sarcomatous components. 53 62
11598856 2001
48
Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. 53 62
10760271 2000
49
Transcription factor GATA-4 is expressed in pediatric yolk sac tumors. 53 62
10595911 1999
50
Methylation imprinting of H19 and SNRPN genes in human benign ovarian teratomas. 53 62
10521301 1999
Sources

Variations for Teratoma

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ClinVar genetic disease variations for Teratoma:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SETBP1 NM_015559.3(SETBP1):c.2614G>A (p.Gly872Arg) SNV Likely Pathogenic
 523513 rs1555706928 GRCh37: 18:42531919-42531919
GRCh38: 18:44951954-44951954
2 CTNNB1 NM_001904.4(CTNNB1):c.1876G>T (p.Glu626Ter) SNV Likely Pathogenic
 523403 rs1553632357 GRCh37: 3:41277912-41277912
GRCh38: 3:41236421-41236421
Sources

Expression for Teratoma

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Search GEO for disease gene expression data for Teratoma.
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Pathways for Teratoma

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Pathways related to Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Wnt / Hedgehog / Notch 3
11.93 SOX2 POU5F1 CTNNB1 AFP
2
Peptide hormone metabolism 66
Show member pathways
 11.85 CTNNB1 CGB5 CGB3 CGA
3
Neural Stem Cells and Lineage-specific Markers 65
11.53 SOX2 MNX1 GFAP
4
Glucocorticoid receptor regulatory network 61
11.5 TP53 CGA AFP
5
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 66
Show member pathways
 11.41 KIT CGB5 CGB3 CGA
6
Pre-implantation embryo 74
11.34 SOX2 POU5F1 NKX2-1
7
Endoderm differentiation 74
11.11 SOX2 POU5F1 NKX2-1 CTNNB1
8
let-7 inhibition of ES cell reprogramming 74
Show member pathways
 10.88 TP53 SOX2 POU5F1
9
Cardiac progenitor differentiation 74
10.65 SOX2 POU5F1 KIT ACTC1
10
Human Early Embryo Development 64
Show member pathways
 10.48 SOX2 POU5F1
Sources

GO Terms for Teratoma

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Cellular components related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pituitary gonadotropin complex GO:0061696 9.02 CGB5 CGB3 CGA

Biological processes related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 TP53 POU5F1 NKX2-1 KIT CTNNB1 ACTC1
2 positive regulation of neuron apoptotic process GO:0043525 9.8 TP53 GRN CTNNB1
3 hormone-mediated signaling pathway GO:0009755 9.55 CGB5 CGB3 CGA
4 endodermal cell fate specification GO:0001714 9.26 SOX2 POU5F1
5 female gamete generation GO:0007292 9.02 CGB7 CGB5 CGB3

Molecular functions related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.17 CGB7 CGB5 CGB3 CGA
Sources

Sources for Teratoma

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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