Teratoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: TRT010 MIFTS: 53	Teratoma Categories: Cancer diseases, Fetal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Teratoma

MalaCards integrated aliases for Teratoma:

Name: Teratoma ¹² ⁷⁷ ³⁰ ⁵⁶ ⁶ ⁴⁵ ¹⁵ ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases Fetal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3307

MeSH ⁴⁵ D013724

NCIt ⁵¹ C3403

SNOMED-CT ⁶⁹ 55818009

UMLS ⁷⁴ C0039538

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Summaries for Teratoma

Disease Ontology : ¹² A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers.

MalaCards based summary : Teratoma is related to sacrococcygeal teratoma and mature teratoma. An important gene associated with Teratoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Cytoskeleton remodeling Neurofilaments. The drugs Mechlorethamine and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷⁷ A teratoma is a tumor made up of several different types of tissue, such as hair, muscle, or bone. They... more...

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Related Diseases for Teratoma

Diseases in the Teratoma family:

Malignant Teratoma	Adult Teratoma
Intermediate Malignant Teratoma

Diseases related to Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 685)

#	Related Disease	Score	Top Affiliating Genes
1	sacrococcygeal teratoma	34.3	AFP CGA MNX1
2	mature teratoma	34.0	AFP POU5F1 TP53
3	ovarian germ cell teratoma	33.9	KRT7 NKX2-1
4	malignant teratoma	33.6	AFP ENO2 POU5F1 SYP TP53
5	dermoid cyst	33.1	KIT KRT7 MNX1
6	testicular germ cell tumor	33.0	AFP CGB3 DMRT1 KIT TP53
7	cystic teratoma	32.9	CDX2 ENO2 GFAP KRT7 NKX2-1 SYP
8	polyembryoma	32.7	AFP CGA
9	testicular cancer	30.6	AFP CGA CGB3
10	mixed germ cell tumor	30.6	AFP CGA CGB3 KIT
11	hepatoblastoma	30.4	AFP KRT7 TP53
12	pseudomyxoma peritonei	30.3	CDX2 KRT7 TP53
13	seminoma	30.2	AFP CGA CGB3 ENO2 KIT POU5F1
14	testicular seminoma	30.2	AFP CGA CGB3
15	chromosomal triplication	30.2	AFP CGA CGB3
16	embryonal testis carcinoma	30.2	AFP POU5F1
17	dysgerminoma	30.2	AFP ENO2 KIT KRT7
18	renal cell carcinoma, papillary, 1	30.1	KIT KRT7 TP53
19	ganglioneuroma	30.1	ENO2 GFAP SYP
20	oligodendroglioma	30.1	ENO2 GFAP SYP TP53
21	ovarian germ cell cancer	30.1	AFP KRT7 NKX2-1
22	mucinous adenocarcinoma	30.1	CDX2 KRT7 NKX2-1
23	carcinosarcoma	30.0	ACTC1 KIT KRT7 TP53
24	testicular yolk sac tumor	30.0	AFP CDX2 POU5F1
25	papillary adenoma	30.0	KRT7 NKX2-1
26	papilloma of choroid plexus	29.9	GFAP SYP TP53
27	ependymoma	29.8	ENO2 GFAP NES SYP
28	adenosquamous carcinoma	29.8	KIT KRT7 NKX2-1 TP53
29	inflammatory myofibroblastic tumor	29.8	ACTC1 KIT TP53
30	hemangioma	29.8	ACTC1 ENO2 NKX2-1 SYP
31	embryonal carcinoma	29.7	AFP KIT NES POU5F1 SOX2
32	benign ependymoma	29.7	ENO2 GFAP SYP
33	endocervical adenocarcinoma	29.7	CDX2 KRT7 TP53
34	leiomyosarcoma	29.6	ACTC1 ENO2 KIT TP53
35	hydrocephalus	29.6	ENO2 GFAP NES SYP TP53
36	neuroendocrine tumor	29.6	ENO2 KRT7 NKX2-1 SYP
37	adenoid cystic carcinoma	29.6	ACTC1 KIT KRT7 TP53
38	central neurocytoma	29.5	ENO2 GFAP NES SYP
39	medullomyoblastoma	29.5	ENO2 GFAP SYP TP53
40	cavernous hemangioma	29.5	KIT KRT7 NKX2-1 SYP
41	small cell carcinoma	29.4	ENO2 KIT KRT7 NKX2-1 SYP TP53
42	ovarian embryonal carcinoma	29.4	AFP POU5F1 SOX2
43	large cell neuroendocrine carcinoma	29.4	ENO2 KIT KRT7 NKX2-1 SYP
44	glomus tumor	29.3	ACTC1 ENO2 SYP TP53
45	germ cell cancer	29.3	AFP CGA DMRT1 KIT POU5F1 SOX2
46	horseshoe kidney	29.2	ACTC1 CDX2 ENO2 KRT7 NKX2-1 SYP
47	gliosarcoma	28.9	ACTC1 ENO2 GFAP NES TP53
48	medulloblastoma	28.5	ACTC1 ENO2 GFAP NES SOX2 SYP
49	immature teratoma of ovary	12.4
50	growing teratoma syndrome	12.4

Graphical network of the top 20 diseases related to Teratoma:

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Symptoms & Phenotypes for Teratoma

GenomeRNAi Phenotypes related to Teratoma according to GeneCards Suite gene sharing:

²⁷ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-114	9.5	AFP
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	9.5	AFP
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	9.5	POU5F1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	9.5	POU5F1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-135	9.5	KRT7
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	9.5	POU5F1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-192	9.5	AFP KRT7 POU5F1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	9.5	AFP
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.5	POU5F1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.5	AFP
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-65	9.5	AFP
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.5	KRT7 POU5F1

MGI Mouse Phenotypes related to Teratoma:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.23	ACTC1 CDX2 ENO2 GFAP GRN KIT
2	behavior/neurological	MP:0005386	10.22	AFP ENO2 GFAP GRN KIT MNX1
3	growth/size/body region	MP:0005378	10.11	ACTC1 CDX2 CGA ENO2 GFAP GRN
4	endocrine/exocrine gland	MP:0005379	10.1	AFP CDX2 CGA DMRT1 KIT MNX1
5	homeostasis/metabolism	MP:0005376	10.1	ACTC1 AFP CDX2 CGA GFAP GRN
6	digestive/alimentary	MP:0005381	10.03	CDX2 GFAP KIT MNX1 NKX2-1 POU5F1
7	nervous system	MP:0003631	9.9	CGA ENO2 GFAP GRN KIT MNX1
8	neoplasm	MP:0002006	9.73	AFP CDX2 KIT NKX2-1 SOX2 TP53
9	normal	MP:0002873	9.65	ACTC1 CDX2 GFAP KIT MNX1 NKX2-1
10	reproductive system	MP:0005389	9.32	AFP CDX2 CGA DMRT1 GRN KIT

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Drugs & Therapeutics for Teratoma

Drugs for Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 179)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Mechlorethamine

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2

51-75-2

4033

Carboplatin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

41575-94-4

38904 10339178 498142

Ifosfamide

Approved

Phase 4,Phase 3,Phase 2,Phase 1

3778-73-2

3690

Etoposide

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

33419-42-0

36462

Cisplatin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

15663-27-1

441203 84093 2767

Topoisomerase Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Etoposide phosphate

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Alkylating Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Isophosphamide mustard

Phase 4,Phase 3,Phase 2,Phase 1

Antineoplastic Agents, Phytogenic

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antineoplastic Agents, Alkylating

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Paclitaxel

Approved, Vet_approved

Phase 3,Phase 2,Phase 1,Not Applicable

33069-62-4

36314

Bleomycin

Approved, Investigational

Phase 3,Phase 2,Not Applicable

11056-06-7

5360373

Oxaliplatin

Approved, Investigational

Phase 3,Phase 2,Phase 1

61825-94-3

6857599 5310940 9887054 43805

Lenograstim

Approved, Investigational

Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable

135968-09-1

Vinblastine

Approved

Phase 3

865-21-4

13342 241903

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 3,Phase 2,Phase 1

1177-87-3

Dexamethasone

Approved, Investigational, Vet_approved

Phase 3,Phase 2,Phase 1

50-02-2

5743

Mesna

Approved, Investigational

Phase 3,Phase 1,Phase 2,Not Applicable

3375-50-6

598

Cyclophosphamide

Approved, Investigational

Phase 3,Phase 2,Phase 1,Not Applicable

6055-19-2, 50-18-0

2907

Captopril

Approved

Phase 3

62571-86-2

44093

Ribavirin

Approved

Phase 3

36791-04-5

37542

Palivizumab

Approved, Investigational

Phase 3

188039-54-5

Itraconazole

Approved, Investigational

Phase 3

84625-61-6

55283

Miconazole

Approved, Investigational, Vet_approved

Phase 3

22916-47-8

4189

Fluconazole

Approved, Investigational

Phase 3

86386-73-4

3365

Caspofungin

Approved

Phase 3

179463-17-3, 162808-62-0

2826718 468682

Amphotericin B

Approved, Investigational

Phase 3

1397-89-3

14956 5280965

Ondansetron

Approved

Phase 3

99614-02-5

4595

Granisetron

Approved, Investigational

Phase 3

109889-09-0

3510

Vincristine

Approved, Investigational

Phase 3,Phase 2,Phase 1

2068-78-2, 57-22-7

5978

Diphenhydramine

Approved, Investigational

Phase 3

147-24-0, 58-73-1

3100

Promethazine

Approved, Investigational

Phase 3

60-87-7

4927

Antibiotics, Antitubercular

Phase 3,Phase 2,Phase 1,Not Applicable

Antimitotic Agents

Phase 3,Phase 2,Phase 1,Not Applicable

Albumin-Bound Paclitaxel

Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Bacterial Agents

Phase 3,Phase 2,Phase 1,Not Applicable

Immunosuppressive Agents

Phase 3,Phase 1,Phase 2,Not Applicable

Immunologic Factors

Phase 3,Phase 1,Phase 2,Not Applicable

Antiviral Agents

Phase 3,Phase 1,Phase 2

Anti-Infective Agents

Phase 3,Phase 1,Phase 2

Antimetabolites

Phase 3,Phase 1,Phase 2

Hormone Antagonists

Phase 3,Phase 2,Phase 1

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3,Phase 2,Phase 1

Hormones

Phase 3,Phase 2,Phase 1

Peripheral Nervous System Agents

Phase 3,Phase 2,Phase 1

Gastrointestinal Agents

Phase 3,Phase 2,Phase 1

BB 1101

Phase 3,Phase 2,Phase 1

Autonomic Agents

Phase 3,Phase 2,Phase 1

Antiemetics

Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 104)

#	Name	Status	NCT ID	Phase	Drugs
1	Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors	Unknown status	NCT01424839	Phase 4	Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
2	Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors	Unknown status	NCT00104676	Phase 3	cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3	Combination Chemotherapy in Treating Men With Germ Cell Cancer	Unknown status	NCT00003643	Phase 2, Phase 3	cisplatin;etoposide;paclitaxel
4	Safety and Efficacy of Antiadhesive Barrier GUARDIX-FL for Women After Laparoscopic Cystectomy	Unknown status	NCT02097446	Phase 3
5	Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors	Unknown status	NCT00274950	Phase 3	carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
6	Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors	Completed	NCT00053352	Phase 3	cisplatin;etoposide
7	Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors	Completed	NCT00002596	Phase 3	carboplatin;cisplatin;cyclophosphamide;etoposide
8	Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation	Completed	NCT00004230	Phase 3	captopril;cyclophosphamide
9	Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation	Completed	NCT00014391	Phase 3	ribavirin
10	Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation	Completed	NCT00003883	Phase 3	fluconazole;itraconazole
11	Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment	Completed	NCT00008359	Phase 3	caspofungin acetate;liposomal amphotericin B
12	Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients	Completed	NCT00003938	Phase 3	liposomal amphotericin B
13	Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer	Completed	NCT00003941	Phase 3	cisplatin;etoposide;ifosfamide
14	Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy	Completed	NCT00716976	Phase 3	sodium thiosulfate
15	Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy	Completed	NCT01346267	Phase 3
16	Single-port LC Might be Preferable for Managing Ovarian Dermoid Cyst.	Completed	NCT02009228	Phase 3
17	Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors	Recruiting	NCT03067181	Phase 3	Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
18	Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors	Recruiting	NCT02375204	Phase 3	paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
19	Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor	Active, not recruiting	NCT00085202	Phase 3	cisplatin;cyclophosphamide;vincristine
20	Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors	Terminated	NCT00072215	Phase 3	cisplatin;ifosfamide;paclitaxel;vinblastine
21	High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy	Unknown status	NCT01172912	Phase 2	carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
22	Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors	Unknown status	NCT00551122	Phase 1, Phase 2	cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
23	A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression	Completed	NCT02300987	Phase 2	LEE011;LEE011 Placebo
24	Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors	Completed	NCT00453232	Phase 2	cisplatin;etoposide
25	Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors	Completed	NCT00301782	Phase 2	carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
26	Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin	Completed	NCT00423852	Phase 1, Phase 2	carboplatin;ifosfamide;paclitaxel
27	Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment	Completed	NCT00453310	Phase 2	sunitinib malate
28	Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors	Completed	NCT00470366	Phase 2	cisplatin;ifosfamide;paclitaxel
29	Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer	Completed	NCT00002931	Phase 2	carboplatin;etoposide;ifosfamide;paclitaxel
30	Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment	Completed	NCT00091182	Phase 2	oxaliplatin
31	Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors	Completed	NCT00002489	Phase 2	carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
32	Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation	Completed	NCT00002673	Phase 2
33	Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation	Completed	NCT00003887	Phase 2
34	Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon	Completed	NCT00010283	Phase 1, Phase 2	beclomethasone dipropionate
35	Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors	Completed	NCT00004157	Phase 2
36	Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer	Completed	NCT00003408	Phase 2
37	Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors	Completed	NCT00070096	Phase 2	ixabepilone
38	Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer	Completed	NCT00004077	Phase 2	cisplatin;ifosfamide;paclitaxel
39	Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors	Completed	NCT00047320	Phase 2	carboplatin;etoposide;ifosfamide;thiotepa
40	Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors	Completed	NCT00002472	Phase 2	cisplatin;etoposide
41	Combination Chemotherapy Plus Amifostine in Treating Children With Malignant Germ Cell Tumors	Completed	NCT00003811	Phase 2	amifostine trihydrate;cisplatin;etoposide
42	High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors	Completed	NCT00003173	Phase 2	thiotepa
43	Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors	Completed	NCT00024258	Phase 2	arsenic trioxide
44	Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors	Completed	NCT00005955	Phase 2	temozolomide
45	Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor	Completed	NCT00047177	Phase 2	Oxaliplatin
46	Contribution of the Imaging to the Expression of intégrines αvβ3 for the Characterization of Residual Masses of Non-seminoma Tumors at the End of Chemotherapy	Recruiting	NCT02317393	Phase 2
47	Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors	Recruiting	NCT00432094	Phase 2	carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
48	Nivolumab and Ipilimumab in Treating Patients With Rare Tumors	Recruiting	NCT02834013	Phase 2
49	PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER	Recruiting	NCT01037790	Phase 2	PD-0332991
50	Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors	Recruiting	NCT02114229	Phase 2	alisertib;methotrexate;cisplatin;carboplatin;cyclophosphamide;etoposide;topotecan;vincristine

Search NIH Clinical Center for Teratoma

Cochrane evidence based reviews: teratoma

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Genetic Tests for Teratoma

Genetic tests related to Teratoma:

#	Genetic test	Affiliating Genes
1	Teratoma ³⁰

Sources

Anatomical Context for Teratoma

MalaCards organs/tissues related to Teratoma:

⁴²

Ovary, Testis, Thyroid, Bone, Brain, Pineal, Spinal Cord

Sources

Publications for Teratoma

Articles related to Teratoma:

(show top 50) (show all 3931)

#	Title	Authors	Year
1	Co-existing monophasic teratoma and uterine adenocarcinoma in a female dog. ( 30907028 )	Pires MA...Payan-Carreira R	2019
2	Benign Ovarian Tumors in Pregnancy: A Case Report of Metachronous Ipsilateral Recurrent Mucinous Cystadenoma in Initial Pregnancy and Mature Cystic Teratoma in Subsequent Pregnancy. ( 30868032 )	Schreck AM...Mikdachi HF	2019
3	Squamous cell carcinoma arising in a partially ruptured giant mature cystic teratoma: A case report. ( 30386447 )	Rowe JS...Germaine P	2019
4	Oncocytic and tall columnar type papillary thyroid carcinoma arising on a mature cystic teratoma: A case report and literature review. ( 30623925 )	Cokmez H...Aydin C	2019
5	Management options for a patient with squamous cell carcinoma arising in a mature cystic teratoma of the ovary. ( 30658026 )	Baum S...Villella J	2019
6	Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A challenging question for gynecologic oncologists. ( 30661663 )	Gadducci A...Cosio S	2019
7	Rare pathology of the ileocaecal valve: mature cystic teratoma. ( 30827054 )	Kandelaki T...Tapper R	2019
8	Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review. ( 30866852 )	Li C...Kong B	2019
9	Primary Mature Cystic Teratoma Compressing the Prostate in a 28-Year-Old Male: A Case Report and Literature Review. ( 30915255 )	Chalhoub K...Jabbour M	2019
10	Multimodal depiction of a rare immature gastric teratoma from fetus to infant. ( 30581526 )	Beavers AJ...Pfeifer CM	2019
11	Growing teratoma syndrome in primary mediastinal germ cell tumor: our experience. ( 30646758 )	Sachdeva AK...Munuswamy H	2019
12	Primary Mediastinal HER2-positive Apocrine Carcinoma in Mature Teratoma Treated With Anti-HER2 Therapy and Chemoradiation. ( 30804140 )	Sugiyama K...Saka H	2019
13	A case report of a giant mature teratoma of the thyroid gland in a young girl. ( 30817608 )	Lv Z...Wu Y	2019
14	Mixed germ cell tumor composed of a tridermic testicular teratoma and seminoma in a rooster. ( 30862303 )	Tavella VJ...LeRoith T	2019
15	Ruptured Teratoma and Chemical Peritonitis. ( 30671566 )	El Moussaoui M...Goffin F	2019
16	Sacrococcygeal teratoma: control of catastrophic haemorrhage. ( 30767354 )	Collins K...Gera P	2019
17	Signet ring cell carcinoma arising from sacrococcygeal teratoma: a case report and review of the literature. ( 30832522 )	Zhou P...Liu D	2019
18	Clinical Monitoring of Sacrococcygeal Teratoma. ( 30893693 )	Wohlmuth C...Gardiner HM	2019
19	Japanese Clinical Practice Guidelines for Sacrococcygeal Teratoma, 2017. ( 30903638 )	Fumino S...Taguchi T	2019
20	Vaginal Teratoma: A Fistulized or Parasitic Recurrent Ovarian Teratoma? A Case Report. ( 30831278 )	Pace M...Dubuisson J	2019
21	Three-step management of a newborn with a giant, highly vascularized, cervical teratoma: a case report. ( 30851737 )	Hochwald O...Kugelman A	2019
22	A Patient With Pure Teratoma of the Testis Presenting With an Anterior Mediastinal Mass. ( 30866033 )	Hertz AM...Banti MM	2019
23	Obstructive teratoma in the right ventricle of a newborn: a case report. ( 30866986 )	Farid Y...Wauthy P	2019
24	A Case Report of Intrapulmonary Teratoma in the Right Upper Lung Zone in a 35-year-old Female Patient. ( 30891375 )	Bawazir AA...Alshammari A	2019
25	Targeting RNA helicase DDX3 in stem cell maintenance and teratoma formation. ( 30899416 )	Kerr CL...Raman V	2019
26	Intratubular Teratoma: A Rare Form of Testicular Germ Cell Neoplasia. ( 30907201 )	Genco IS...Unger P	2019
27	Ocular structures in a mature ovarian teratoma. ( 30505981 )	Allan Sharpe R...Perry LJP	2019
28	Derivation of pluripotent stem cells from nascent undifferentiated teratoma. ( 30529251 )	An Y...Matsui Y	2019
29	Primary Pedunculated Solid Teratoma of the Rectum. ( 30625405 )	Yoshizaki T...Okada A	2019
30	Identification of a giant mediastinal teratoma by echocardiography: A case report. ( 30635906 )	Xiao-Dong L...Xiao-Cong W	2019
31	Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature. ( 30660187 )	Maghrabi Y...Baeesa SS	2019
32	Experience of applying cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for ovarian teratoma with malignant transformation and peritoneal dissemination. ( 30679911 )	Yu HH...Shan YS	2019
33	A case of ovarian teratoma with nephroblastoma presenting spontaneous rupture. ( 30701637 )	Nakabayashi A...Matsui H	2019
34	Endoscopic Transnasal Resection of Suprasellar Teratoma. ( 30708386 )	Ajlan AM...Albakr A	2019
35	Perinatal intracardiac teratoma: unusual presentation and review of the literature. ( 30732668 )	Moreau de Bellaing A...Bonnet D	2019
36	Primary Malignant Thyroid Teratoma: An Institutional Experience. ( 30759052 )	Ting J...Zafereo M	2019
37	Robotic single-site surgery for mature cyst teratoma cystectomy: an initial case series study in a single medical center in China. ( 30774353 )	Liu Z...Tao Y	2019
38	True Ectopic Ovary with Mature Cystic Teratoma. ( 29684524 )	Lee C.Y....Wang C.J.	2018
39	High Tumor Volume to Fetal Weight Ratio Is Associated with Worse Fetal Outcomes and Increased Maternal Risk in Fetuses with Sacrococcygeal Teratoma. ( 29495013 )	Gebb J.S....Moldenhauer J.S.	2018
40	A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type <i>C. elegans</i>. ( 29928508 )	Wang H....Gems D.	2018
41	Cerebellar Differentiation in Ovarian Teratoma: A Report of 6 Cases. ( 29889717 )	Stewart C.J.R....Crook M.L.	2018
42	Metastatic mediastinal mature teratoma with malignant transformation in a young man with an adenocarcinoma in a Klinefelter's syndrome: Case report and review of the literature. ( 29673950 )	Le FA"vre C....NoAl G.	2018
43	Comparison of Teratoma Formation between Embryonic Stem Cells and Parthenogenetic Embryonic Stem Cells by Molecular Imaging. ( 29765423 )	Tao H....Li Z.	2018
44	Massive fetal cervical teratoma managed with the ex utero intrapartum treatment (EXIT) procedure. ( 29904479 )	Olivares E....Fong V.	2018
45	Testicular Yolk Sac Tumor and Mature Teratoma: Synchronous Bilateral Occurrence in an Infant. ( 29608939 )	Dong S....Wang S.	2018
46	Chondroid nodule in the female peritoneum arises from normal tissue and not from teratoma or conception product. ( 29368082 )	Franceschi T....Devouassoux-Shisheboran M.	2018
47	Thymic teratoma presenting as non-immune hydrops fetalis. ( 29515979 )	Hamza A....Higgins M.J.	2018
48	Orbital immature teratoma: A rare entity with diagnostic challenges. ( 29755277 )	Alkatan H.M....Al-Faky Y.H.	2018
49	Gliomatosis peritonei with <sup>18</sup>F-fluorodeoxyglucose accumulation and contrast enhancement secondary to immature teratoma: A case report. ( 29977538 )	Ohara T....Suginami K.	2018
50	Growing Teratoma Syndrome of Testicular Origin. ( 29807046 )	Nassiri N....Daneshmand S.	2018

Sources

Genes for Teratoma

Genes related to Teratoma (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	AFP	Alpha Fetoprotein	Protein Coding	44.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Summaries (show sections)	10386812 19493258 9258169 (more) 11745252 7685750 2162137 7543786 8976653 16896894 1696873 18525461 19156903 16503489 9354734 19453084 15567952 7537801 17350873 15272600 15218952 19142973 15895292 15613854 15802029 9648599 8934053 20088167 10427494 9202859 1704432 19785009 19198853 9021828 9440752
2	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	35.82	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	7514496 19912360 18057715
3	POU5F1	POU Class 5 Homeobox 1	Protein Coding	34.73	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	18439155 19826408 16494961 (more) 12161760 16978057 17535850 18062871 18393636
4	MNX1	Motor Neuron And Pancreas Homeobox 1	Protein Coding	30.33	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	14663834
5	KRT7	Keratin 7	Protein Coding	28.43	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19577382
6	ENO2	Enolase 2	Protein Coding	27.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	2024455 8938952
7	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	27.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	9524573 1656435
8	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	25.27	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	1680200 9535605 15247758
9	NKX2-1	NK2 Homeobox 1	Protein Coding	24.63	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	18628097 16512597
10	SOX2	SRY-Box 2	Protein Coding	24.59	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	17464316
11	GRN	Granulin Precursor	Protein Coding	23.27	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	10760271 10066447
12	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	22.69	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	9021828 10743710 15272600 (more) 17350873 9648599 1691781
13	DMRT1	Doublesex And Mab-3 Related Transcription Factor 1	Protein Coding	22.45	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
14	CDX2	Caudal Type Homeobox 2	Protein Coding	22.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	SYP	Synaptophysin	Protein Coding	22.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	22.26	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	20363201
17	NES	Nestin	Protein Coding	22.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	15127288 18611917
18	TP53	Tumor Protein P53	Protein Coding	21.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	CD99	CD99 Molecule (Xg Blood Group)	Protein Coding	14.77	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11598856

Sources

Variations for Teratoma

ClinVar genetic disease variations for Teratoma:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	CTNNB1	NM_001098209.1(CTNNB1): c.1876G> T (p.Glu626Ter)	single nucleotide variant	Likely pathogenic	rs1553632357	GRCh37	Chromosome 3, 41277912: 41277912
2	CTNNB1	NM_001098209.1(CTNNB1): c.1876G> T (p.Glu626Ter)	single nucleotide variant	Likely pathogenic	rs1553632357	GRCh38	Chromosome 3, 41236421: 41236421
3	SETBP1	NM_015559.3(SETBP1): c.2614G> A (p.Gly872Arg)	single nucleotide variant	Likely pathogenic	rs1555706928	GRCh38	Chromosome 18, 44951954: 44951954
4	SETBP1	NM_015559.3(SETBP1): c.2614G> A (p.Gly872Arg)	single nucleotide variant	Likely pathogenic	rs1555706928	GRCh37	Chromosome 18, 42531919: 42531919

Sources

Expression for Teratoma

Search GEO for disease gene expression data for Teratoma.

Sources

Pathways for Teratoma

Pathways related to Teratoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Wnt / Hedgehog / Notch ⁴	11.93	AFP CDX2 POU5F1 SOX2
2	Cytoskeleton remodeling Neurofilaments ²³ Show member pathways Cytoskeleton remodeling Keratin filaments ²³	11.69	GFAP KRT7 NES
3	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁷ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁷ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁷ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁷ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁷ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁷ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁷	11.6	CGA CGB3 KIT
4	Glucocorticoid receptor regulatory network ¹	11.52	AFP CGA TP53
5	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.48	AFP CDX2 NES POU5F1 SOX2
6	Preimplantation Embryo ¹	11.34	CDX2 NKX2-1 POU5F1 SOX2
7	Cardiac Progenitor Differentiation ¹	11.18	ACTC1 KIT POU5F1 SOX2
8	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	10.92	GFAP MNX1 NES SOX2 SYP
9	Oct4 in Mammalian ESC Pluripotency ⁶⁵	10.73	CDX2 POU5F1 SOX2
10	Human Early Embryo Development ⁶⁵ Show member pathways POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation ⁶⁷	10.4	POU5F1 SOX2

Sources

GO Terms for Teratoma

Biological processes related to Teratoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of transcription by RNA polymerase II	GO:0000122	9.73	CDX2 DMRT1 NKX2-1 POU5F1 SOX2 TP53
2	positive regulation of gene expression	GO:0010628	9.55	ACTC1 KIT NKX2-1 POU5F1 TP53
3	response to wounding	GO:0009611	9.54	GFAP POU5F1 SOX2
4	germ cell migration	GO:0008354	9.32	DMRT1 KIT
5	endodermal cell fate specification	GO:0001714	8.96	POU5F1 SOX2
6	somatic stem cell population maintenance	GO:0035019	8.92	CDX2 KIT POU5F1 SOX2

Molecular functions related to Teratoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding	GO:0043565	9.43	CDX2 DMRT1 MNX1 NKX2-1 POU5F1 SOX2
2	RNA polymerase II distal enhancer sequence-specific DNA binding	GO:0000980	9.33	CDX2 NKX2-1 TP53
3	DNA-binding transcription factor activity	GO:0003700	9.17	CDX2 DMRT1 MNX1 NKX2-1 POU5F1 SOX2

Sources

Sources for Teratoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia