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MCID: TRT010
MIFTS: 52

Teratoma

Categories: Cancer diseases, Fetal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Teratoma

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MalaCards integrated aliases for Teratoma:

Name: Teratoma 12 77 56 6 45 15 74

Classifications:

MalaCards categories:
Global: Cancer diseases Fetal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3307
MeSH 45 D013724
NCIt 51 C3403
SNOMED-CT 69 55818009
UMLS 74 C0039538
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Summaries for Teratoma

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Disease Ontology : 12 A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers.

MalaCards based summary : Teratoma is related to sacrococcygeal teratoma and mature teratoma. An important gene associated with Teratoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Cytoskeleton remodeling Neurofilaments. The drugs Ifosfamide and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 A teratoma is a tumor made up of several different types of tissue, such as hair, muscle, teeth, or... more...

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Related Diseases for Teratoma

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Diseases in the Teratoma family:

Malignant Teratoma Adult Teratoma
Intermediate Malignant Teratoma

Diseases related to Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 718)
# Related Disease Score Top Affiliating Genes
1 sacrococcygeal teratoma 34.3 AFP CGA MNX1
2 mature teratoma 34.0 AFP POU5F1 TP53
3 ovarian germ cell teratoma 33.9 KRT7 NKX2-1
4 malignant teratoma 33.6 AFP ENO2 POU5F1 SYP TP53
5 dermoid cyst 33.1 KIT KRT7 MNX1
6 testicular germ cell tumor 33.1 AFP CGB3 DMRT1 KIT TP53
7 cystic teratoma 33.0 CDX2 ENO2 GFAP KRT7 NKX2-1 SYP
8 polyembryoma 32.7 AFP CGA
9 appendix adenocarcinoma 31.1 CDX2 KRT7
10 testicular cancer 30.7 AFP CGA CGB3
11 chromosomal triplication 30.6 AFP CGA CGB3
12 mixed germ cell tumor 30.6 AFP CGA CGB3 KIT
13 hepatoblastoma 30.4 AFP KRT7 TP53
14 pseudomyxoma peritonei 30.4 CDX2 KRT7 TP53
15 seminoma 30.2 AFP CGA CGB3 ENO2 KIT POU5F1
16 testicular seminoma 30.2 AFP CGA CGB3
17 benign ependymoma 30.2 ENO2 GFAP SYP
18 brain germinoma 30.2 AFP POU5F1
19 embryonal testis carcinoma 30.2 AFP POU5F1
20 ovarian germ cell cancer 30.2 AFP KRT7 NKX2-1
21 dysgerminoma 30.2 AFP ENO2 KIT KRT7
22 renal cell carcinoma, papillary, 1 30.1 KIT KRT7 TP53
23 ganglioneuroma 30.1 ENO2 GFAP SYP
24 oligodendroglioma 30.1 ENO2 GFAP SYP TP53
25 mucinous adenocarcinoma 30.1 CDX2 KRT7 NKX2-1
26 embryoma 30.0 AFP CDX2 KIT POU5F1
27 carcinosarcoma 30.0 ACTC1 KIT KRT7 TP53
28 testicular yolk sac tumor 30.0 AFP CDX2 POU5F1
29 papillary adenoma 30.0 KRT7 NKX2-1
30 papilloma of choroid plexus 29.9 GFAP SYP TP53
31 ependymoma 29.8 ENO2 GFAP NES SYP
32 adenosquamous carcinoma 29.8 KIT KRT7 NKX2-1 TP53
33 inflammatory myofibroblastic tumor 29.8 ACTC1 KIT TP53
34 hemangioma 29.8 ACTC1 ENO2 NKX2-1 SYP
35 embryonal carcinoma 29.7 AFP KIT NES POU5F1 SOX2
36 meningioma, familial 29.7 ENO2 GFAP SYP TP53
37 ovarian mucinous neoplasm 29.7 CDX2 KRT7 SYP
38 endocervical adenocarcinoma 29.7 CDX2 KRT7 TP53
39 central neurocytoma 29.7 ENO2 GFAP NES SYP
40 leiomyosarcoma 29.6 ACTC1 ENO2 KIT TP53
41 hydrocephalus 29.6 ENO2 GFAP NES SYP TP53
42 neuroendocrine tumor 29.6 ENO2 KRT7 NKX2-1 SYP
43 adenoid cystic carcinoma 29.6 ACTC1 KIT KRT7 TP53
44 germ cell cancer 29.5 AFP CGA DMRT1 KIT POU5F1 SOX2
45 medullomyoblastoma 29.5 ENO2 GFAP SYP TP53
46 cavernous hemangioma 29.5 KIT KRT7 NKX2-1 SYP
47 small cell carcinoma 29.4 ENO2 KIT KRT7 NKX2-1 SYP TP53
48 ovarian embryonal carcinoma 29.4 AFP POU5F1 SOX2
49 large cell neuroendocrine carcinoma 29.4 ENO2 KIT KRT7 NKX2-1 SYP
50 horseshoe kidney 29.3 ACTC1 CDX2 ENO2 KRT7 NKX2-1 SYP

Graphical network of the top 20 diseases related to Teratoma:



Diseases related to Teratoma
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Symptoms & Phenotypes for Teratoma

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GenomeRNAi Phenotypes related to Teratoma according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.5 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.5 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.5 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.5 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.5 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.5 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.5 AFP KRT7 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.5 AFP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.5 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.5 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.5 AFP
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.5 KRT7 POU5F1

MGI Mouse Phenotypes related to Teratoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.23 ACTC1 CDX2 ENO2 GFAP GRN KIT
2 behavior/neurological MP:0005386 10.22 AFP ENO2 GFAP GRN KIT MNX1
3 growth/size/body region MP:0005378 10.11 ACTC1 CDX2 CGA ENO2 GFAP GRN
4 endocrine/exocrine gland MP:0005379 10.1 AFP CDX2 CGA DMRT1 KIT MNX1
5 homeostasis/metabolism MP:0005376 10.1 ACTC1 AFP CDX2 CGA GFAP GRN
6 digestive/alimentary MP:0005381 10.03 CDX2 GFAP KIT MNX1 NKX2-1 POU5F1
7 nervous system MP:0003631 9.9 CGA ENO2 GFAP GRN KIT MNX1
8 neoplasm MP:0002006 9.73 AFP CDX2 KIT NKX2-1 SOX2 TP53
9 normal MP:0002873 9.65 ACTC1 CDX2 GFAP KIT MNX1 NKX2-1
10 reproductive system MP:0005389 9.32 AFP CDX2 CGA DMRT1 GRN KIT
Sources

Drugs & Therapeutics for Teratoma

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Drugs for Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 179)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
2
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
3
Mechlorethamine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 51-75-2 4033
4
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
5
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 2767 441203 84093
6 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10
Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1 0
11 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12
Bleomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 11056-06-7 5360373
13
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
14
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
15
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 135968-09-1
16
Vinblastine Approved Phase 3 865-21-4 241903 13342
17
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
19
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 3375-50-6 598
20
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
21
Captopril Approved Phase 3 62571-86-2 44093
22
Ribavirin Approved Phase 3 36791-04-5 37542
23
Palivizumab Approved, Investigational Phase 3 188039-54-5
24
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
25
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
26
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
27
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
28
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
29
Ondansetron Approved Phase 3 99614-02-5 4595
30
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
31
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
32
Promethazine Approved, Investigational Phase 3 60-87-7 4927
33
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
34 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
35 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
36 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1,Not Applicable
37 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Not Applicable
38 Immunologic Factors Phase 3,Phase 1,Phase 2,Not Applicable
39 Immunosuppressive Agents Phase 3,Phase 1,Phase 2,Not Applicable
40 Antiviral Agents Phase 3,Phase 1,Phase 2
41 Anti-Infective Agents Phase 3,Phase 1,Phase 2
42 Antimetabolites Phase 3,Phase 1,Phase 2
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
44 Hormone Antagonists Phase 3,Phase 2,Phase 1
45 Hormones Phase 3,Phase 2,Phase 1
46 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
47 Antiemetics Phase 3,Phase 2,Phase 1
48 BB 1101 Phase 3,Phase 2,Phase 1
49 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
50 Autonomic Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 107)
# Name Status NCT ID Phase Drugs
1 Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors Unknown status NCT01424839 Phase 4 Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
4 Safety and Efficacy of Antiadhesive Barrier GUARDIX-FL for Women After Laparoscopic Cystectomy Unknown status NCT02097446 Phase 3
5 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
6 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
7 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
8 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
9 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
10 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
11 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
12 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
13 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
14 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
15 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
16 Single-port LC Might be Preferable for Managing Ovarian Dermoid Cyst. Completed NCT02009228 Phase 3
17 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
18 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
19 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Active, not recruiting NCT00085202 Phase 3 cisplatin;cyclophosphamide;vincristine
20 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
21 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
22 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
23 A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression Completed NCT02300987 Phase 2 LEE011;LEE011 Placebo
24 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
25 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
26 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
27 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
28 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
29 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
30 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
31 Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
32 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
33 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
34 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
35 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
36 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
37 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
38 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
39 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
40 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
41 Combination Chemotherapy Plus Amifostine in Treating Children With Malignant Germ Cell Tumors Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
42 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
43 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
44 Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors Completed NCT00005955 Phase 2 temozolomide
45 Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Completed NCT00047177 Phase 2 Oxaliplatin
46 Contribution of the Imaging to the Expression of intégrines αvβ3 for the Characterization of Residual Masses of Non-seminoma Tumors at the End of Chemotherapy Recruiting NCT02317393 Phase 2
47 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
48 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
49 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
50 Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors Recruiting NCT02114229 Phase 2 alisertib;methotrexate;cisplatin;carboplatin;cyclophosphamide;etoposide;topotecan;vincristine

Search NIH Clinical Center for Teratoma

Cochrane evidence based reviews: teratoma

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Genetic Tests for Teratoma

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Anatomical Context for Teratoma

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MalaCards organs/tissues related to Teratoma:

42
Ovary, Testis, Thyroid, Pineal, Brain, Spinal Cord, Pituitary
Sources

Publications for Teratoma

About this section

Articles related to Teratoma:

(show top 50) (show all 3958)
# Title Authors Year
1
Co-existing monophasic teratoma and uterine adenocarcinoma in a female dog. ( 30907028 )
2019
2
Development of angiosarcoma in a mediastinal non-seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy. ( 30407736 )
2019
3
Benign Ovarian Tumors in Pregnancy: A Case Report of Metachronous Ipsilateral Recurrent Mucinous Cystadenoma in Initial Pregnancy and Mature Cystic Teratoma in Subsequent Pregnancy. ( 30868032 )
2019
4
Ruptured cystic teratoma associated with mucinous cystadenoma in a pregnant woman. ( 30975966 )
2019
5
Report: Laparoscopic management for coexistent parasitic ovarian teratoma of the omentum and ovarian mucinous cystadenoma: A case report. ( 31081783 )
2019
6
True Ectopic Ovary with Mature Cystic Teratoma. ( 29684524 )
2019
7
Pregnancy complicated by ovarian planoepithelial carcinoma arising in mature cystic teratoma. ( 30244628 )
2019
8
Squamous cell carcinoma arising in a partially ruptured giant mature cystic teratoma: A case report. ( 30386447 )
2019
9
Oncocytic and tall columnar type papillary thyroid carcinoma arising on a mature cystic teratoma: A case report and literature review. ( 30623925 )
2019
10
Management options for a patient with squamous cell carcinoma arising in a mature cystic teratoma of the ovary. ( 30658026 )
2019
11
Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A challenging question for gynecologic oncologists. ( 30661663 )
2019
12
Rare pathology of the ileocaecal valve: mature cystic teratoma. ( 30827054 )
2019
13
Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review. ( 30866852 )
2019
14
Primary Mature Cystic Teratoma Compressing the Prostate in a 28-Year-Old Male: A Case Report and Literature Review. ( 30915255 )
2019
15
Extragonadal yolk sac tumor following congenital buccal mature cystic teratoma. ( 30967724 )
2019
16
Recurrence of retroperitoneal mature cystic teratoma in an adult: A case report. ( 30976370 )
2019
17
Fibrin-associated diffuse large B-cell lymphoma arising in a mature cystic teratoma: A case report. ( 30977946 )
2019
18
Mature cystic teratoma of ovary with squamous cell carcinoma arising from it. ( 30997060 )
2019
19
Coexistence of Papillary Thyroid Cancer and Hashimoto's Thyroiditis Developing within an Ovarian Mature Cystic Teratoma. ( 31001057 )
2019
20
Review of Laparoscopic Management of Mature Cystic Teratoma of Ovaries in Children. ( 31105392 )
2019
21
Ovarian Lymphangioma with Mature Cystic Teratoma. ( 31110394 )
2019
22
Two cases of anti-N-methyl-d-aspartate-receptor encephalitis associated with ovarian teratoma. ( 31010348 )
2019
23
Anti-NMDA receptor encephalitis: two case reports associated with ovarian teratoma and a literature review. ( 31017481 )
2019
24
Multimodal depiction of a rare immature gastric teratoma from fetus to infant. ( 30581526 )
2019
25
Growing Teratoma Syndrome of Testicular Origin. ( 29807046 )
2019
26
Growing teratoma syndrome in primary mediastinal germ cell tumor: our experience. ( 30646758 )
2019
27
Growing teratoma syndrome with porta hepatis involvement - a case report. ( 30962727 )
2019
28
Clinical Management and Outcome in Extreme Retroperitoneal Growing Teratoma Syndrome of Testicular Origin - Clinical Management and Effect of the Treatment. ( 30995853 )
2019
29
Novel heterozygous mutation in the PTEN gene associated with ovarian germ cell tumor complicated by growing teratoma syndrome and overgrowth in a two-year-old female. ( 31038288 )
2019
30
Unusual Case of Malignant Struma Ovarii and Cervical Thyroid Cancer Preceded by Ovarian Teratoma: Case Report and Review of the Literature. ( 31007958 )
2019
31
Unusual Radiographic Presentation of Intracranial Mature Teratoma and Resection via Supraorbital Approach. ( 30368015 )
2019
32
Primary Mediastinal HER2-positive Apocrine Carcinoma in Mature Teratoma Treated With Anti-HER2 Therapy and Chemoradiation. ( 30804140 )
2019
33
A case report of a giant mature teratoma of the thyroid gland in a young girl. ( 30817608 )
2019
34
Mature teratoma containing carcinoid tumour arising within a fallopian tube. ( 30936334 )
2019
35
Resection of a superior mediastinal mature teratoma using intraoperative neural monitoring. ( 30981848 )
2019
36
Intracranial Mature Teratoma in an Adult Patient: A Case Report. ( 31041158 )
2019
37
Mature Teratoma of Petrous Temporal Bone in an Infant: A rare clinical entity. ( 31048042 )
2019
38
Congenital intracranial mature teratoma: the role of fetal MRI over ultrasound in the prenatal diagnosis and the perinatal management. ( 31064792 )
2019
39
Mixed germ cell tumor composed of a tridermic testicular teratoma and seminoma in a rooster. ( 30862303 )
2019
40
Paraneoplastic neuromyelitis optica and ovarian teratoma: A case series. ( 30954932 )
2019
41
Ovarian Cancer Immature Teratoma Type in Pregnancy: Management and Feto-Maternal Outcomes. ( 30976352 )
2019
42
Anterior mediastinal teratoma with pericardial effusion. Rare presentation. ( 31086650 )
2019
43
Ruptured Teratoma and Chemical Peritonitis. ( 30671566 )
2019
44
High Tumor Volume to Fetal Weight Ratio Is Associated with Worse Fetal Outcomes and Increased Maternal Risk in Fetuses with Sacrococcygeal Teratoma. ( 29495013 )
2019
45
Acquired Urethrovaginal Fistula and Urethral Atresia in a Patient with a Sacrococcygeal Teratoma. ( 30297116 )
2019
46
Sacrococcygeal teratoma: control of catastrophic haemorrhage. ( 30767354 )
2019
47
Signet ring cell carcinoma arising from sacrococcygeal teratoma: a case report and review of the literature. ( 30832522 )
2019
48
Clinical Monitoring of Sacrococcygeal Teratoma. ( 30893693 )
2019
49
Japanese Clinical Practice Guidelines for Sacrococcygeal Teratoma, 2017. ( 30903638 )
2019
50
Preoperative selective embolization with vascular coiling of giant sacrococcygeal teratoma. ( 30932896 )
2019
Sources

Variations for Teratoma

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ClinVar genetic disease variations for Teratoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CTNNB1 NM_001098209.1(CTNNB1): c.1876G> T (p.Glu626Ter) single nucleotide variant Likely pathogenic rs1553632357 GRCh37 Chromosome 3, 41277912: 41277912
2 CTNNB1 NM_001098209.1(CTNNB1): c.1876G> T (p.Glu626Ter) single nucleotide variant Likely pathogenic rs1553632357 GRCh38 Chromosome 3, 41236421: 41236421
3 SETBP1 NM_015559.3(SETBP1): c.2614G> A (p.Gly872Arg) single nucleotide variant Likely pathogenic rs1555706928 GRCh38 Chromosome 18, 44951954: 44951954
4 SETBP1 NM_015559.3(SETBP1): c.2614G> A (p.Gly872Arg) single nucleotide variant Likely pathogenic rs1555706928 GRCh37 Chromosome 18, 42531919: 42531919
Sources

Expression for Teratoma

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Search GEO for disease gene expression data for Teratoma.
Sources

Pathways for Teratoma

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Pathways related to Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Wnt / Hedgehog / Notch 4
11.93 AFP CDX2 POU5F1 SOX2
2
Cytoskeleton remodeling Neurofilaments 23
Show member pathways
 11.69 GFAP KRT7 NES
3
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 67
Show member pathways
 11.6 CGA CGB3 KIT
4
Glucocorticoid receptor regulatory network 1
11.52 AFP CGA TP53
5
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.48 AFP CDX2 NES POU5F1 SOX2
6
Preimplantation Embryo 1
11.34 CDX2 NKX2-1 POU5F1 SOX2
7
Cardiac Progenitor Differentiation 1
11.18 ACTC1 KIT POU5F1 SOX2
8
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
10.92 GFAP MNX1 NES SOX2 SYP
9
Oct4 in Mammalian ESC Pluripotency 65
10.73 CDX2 POU5F1 SOX2
10
Human Early Embryo Development 65
Show member pathways
 10.4 POU5F1 SOX2
Sources

GO Terms for Teratoma

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Biological processes related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.73 CDX2 DMRT1 NKX2-1 POU5F1 SOX2 TP53
2 positive regulation of gene expression GO:0010628 9.55 ACTC1 KIT NKX2-1 POU5F1 TP53
3 response to wounding GO:0009611 9.54 GFAP POU5F1 SOX2
4 germ cell migration GO:0008354 9.32 DMRT1 KIT
5 endodermal cell fate specification GO:0001714 8.96 POU5F1 SOX2
6 somatic stem cell population maintenance GO:0035019 8.92 CDX2 KIT POU5F1 SOX2

Molecular functions related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.43 CDX2 DMRT1 MNX1 NKX2-1 POU5F1 SOX2
2 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.33 CDX2 NKX2-1 TP53
3 DNA-binding transcription factor activity GO:0003700 9.17 CDX2 DMRT1 MNX1 NKX2-1 POU5F1 SOX2
Sources

Sources for Teratoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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