MCID: TRT010
MIFTS: 52

Teratoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Teratoma

MalaCards integrated aliases for Teratoma:

Name: Teratoma 12 74 54 6 43 15 71
Teratomas 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3307
MeSH 43 D013724
NCIt 49 C3403
UMLS 71 C0039538

Summaries for Teratoma

Disease Ontology : 12 A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers.

MalaCards based summary : Teratoma, also known as teratomas, is related to sacrococcygeal teratoma and adult teratoma. An important gene associated with Teratoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Captopril and Fluconazole have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and thyroid, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 A teratoma is a tumor made up of several different types of tissue, such as hair, muscle, teeth, or... more...

Related Diseases for Teratoma

Diseases in the Teratoma family:

Benign Teratoma Malignant Teratoma
Adult Teratoma Intermediate Malignant Teratoma

Diseases related to Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1183)
# Related Disease Score Top Affiliating Genes
1 sacrococcygeal teratoma 35.0 MNX1 CGB7 CGA AFP
2 adult teratoma 34.7 TP53 AFP
3 ovarian cystic teratoma 34.7 NKX2-1 AFP
4 mature teratoma of the ovary 34.6 ENO2 AFP
5 ovarian germ cell teratoma 34.5 SYP NKX2-1 KRT7 AFP
6 mature teratoma 34.5 TP53 SYP POU5F1 KRT7 KIT ENO2
7 pineal region teratoma 34.4 SYP KIT ENO2 AFP
8 malignant teratoma 34.3 SYP SOX2 POU5F1 KIT ENO2 CD99
9 cystic teratoma 34.2 TP53 SYP NKX2-1 KRT7 KIT GFAP
10 benign teratoma 34.2 TP53 SYP NKX2-1 MNX1 KRT7 ENO2
11 testicular germ cell tumor 34.1 TP53 KIT DMRT1 CGB3 AFP
12 central nervous system immature teratoma 33.9 SOX2 NES GFAP
13 endodermal sinus tumor 33.4 POU5F1 KRT7 KIT CGB3 AFP
14 polyembryoma 33.3 CGA AFP
15 testicular cancer 33.1 TP53 DMRT1 CGB3 CGA AFP
16 mixed germ cell cancer 33.1 KIT AFP
17 ovarian germ cell cancer 32.9 SYP POU5F1 NKX2-1 KRT7 KIT AFP
18 nonseminomatous germ cell tumor 31.8 CGB7 AFP
19 appendix adenocarcinoma 31.7 SYP KRT7 CDX2
20 mixed germ cell tumor 31.6 KIT CGB3 CGA AFP
21 adenocarcinoma 31.6 TP53 NKX2-1 KRT7 KIT CDX2
22 rare tumor 31.6 KIT ACTC1
23 chromosomal triplication 31.5 CGB7 CGB3 AFP
24 germinoma 31.5 POU5F1 KIT CGB3 CGA AFP
25 mucinous adenocarcinoma 31.4 TP53 NKX2-1 KRT7 KIT CDX2
26 cystadenoma 31.4 SYP KRT7 KIT AFP
27 adenoma 31.3 TP53 SYP KRT7 CDX2
28 intestinal obstruction 31.3 KRT7 KIT CDX2
29 pseudomyxoma peritonei 31.3 TP53 KRT7 CDX2
30 cystadenocarcinoma 31.2 TP53 KRT7 ACTC1
31 oligodendroglioma 31.2 TP53 SYP GFAP ENO2
32 hydrocephalus 31.2 TP53 SYP NES GFAP ENO2
33 obstructive hydrocephalus 31.2 SYP GFAP ENO2 AFP
34 lymphangioma 31.2 TP53 CDX2 ACTC1
35 angiosarcoma 31.2 TP53 KRT7 KIT
36 dysgerminoma 31.1 POU5F1 KRT7 KIT ENO2 DMRT1 AFP
37 neuroendocrine tumor 31.1 SYP NKX2-1 ENO2 CDX2
38 ectopic pregnancy 31.1 CGB7 CGB3 CGA AFP
39 ovarian mixed germ cell neoplasm 31.1 KIT CGA AFP
40 carcinosarcoma 31.0 TP53 KRT7 KIT ACTC1
41 testicular seminoma 31.0 CGB3 CGA AFP
42 neural tube defects 31.0 TP53 SYP MNX1 GFAP ENO2 CGB7
43 gangliocytoma 30.9 SYP GFAP ENO2
44 embryonal carcinoma 30.9 SOX2 POU5F1 NES KIT CGB3 AFP
45 leiomyosarcoma 30.9 TP53 KIT ENO2 ACTC1
46 ovarian benign neoplasm 30.9 TP53 KRT7 AFP
47 neuroendocrine carcinoma 30.9 SYP NKX2-1 KRT7 KIT ENO2
48 gonadoblastoma 30.9 POU5F1 KIT DMRT1 CGB3
49 signet ring cell adenocarcinoma 30.9 TP53 KRT7 CDX2
50 meningioma, familial 30.8 TP53 SYP GFAP ENO2

Graphical network of the top 20 diseases related to Teratoma:



Diseases related to Teratoma

Symptoms & Phenotypes for Teratoma

GenomeRNAi Phenotypes related to Teratoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.17 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.17 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.17 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.17 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.17 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.17 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.17 AFP

MGI Mouse Phenotypes related to Teratoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.15 ACTC1 CDX2 ENO2 GFAP GRN KIT
2 endocrine/exocrine gland MP:0005379 9.96 AFP CDX2 CGA DMRT1 KIT MNX1
3 nervous system MP:0003631 9.93 ACTC1 CGA ENO2 GFAP GRN KIT
4 digestive/alimentary MP:0005381 9.92 CDX2 GFAP KIT MNX1 NKX2-1 POU5F1
5 normal MP:0002873 9.65 ACTC1 CDX2 GFAP KIT MNX1 NKX2-1
6 reproductive system MP:0005389 9.32 AFP CDX2 CGA DMRT1 GRN KIT

Drugs & Therapeutics for Teratoma

Drugs for Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 178)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Captopril Approved Phase 3 62571-86-2 44093
2
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
3
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
4
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
5
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
6
Ribavirin Approved Phase 3 36791-04-5 37542
7
Palivizumab Approved, Investigational Phase 3 188039-54-5
8
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
9
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
10
Ondansetron Approved Phase 3 99614-02-5 4595
11
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
12
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
13
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
14
Mesna Approved, Investigational Phase 3 3375-50-6 598
15
Promethazine Approved, Investigational Phase 3 60-87-7 4927
16
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
17
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
18
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
19
Vinblastine Approved Phase 3 865-21-4 241903 13342
20 Antihypertensive Agents Phase 3
21 Angiotensin-Converting Enzyme Inhibitors Phase 3
22 HIV Protease Inhibitors Phase 3
23
protease inhibitors Phase 3
24 Cytochrome P-450 Enzyme Inhibitors Phase 3
25
Hydroxyitraconazole Phase 3
26 Antifungal Agents Phase 3
27 Cytochrome P-450 CYP3A Inhibitors Phase 3
28 Amebicides Phase 3
29 Antiparasitic Agents Phase 3
30 Antiprotozoal Agents Phase 3
31 Liposomal amphotericin B Phase 3
32 Emetics Phase 3
33 Albumin-Bound Paclitaxel Phase 3
34 Tubulin Modulators Phase 3
35 Antimitotic Agents Phase 3
36 Histamine H2 Antagonists Phase 3
37 Antibiotics, Antitubercular Phase 3
38
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
39
Chlorpheniramine Approved Phase 1, Phase 2 132-22-9, 113-92-8 2725
40
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
41
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
42
Oprelvekin Approved, Investigational Phase 2 145941-26-0
43
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
44
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
45
Iodine Approved, Investigational Phase 2 7553-56-2 807
46
Povidone Approved Phase 2 9003-39-8
47
Povidone-iodine Approved Phase 2 25655-41-8
48
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
49
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
50
Palbociclib Approved, Investigational Phase 2 571190-30-2 5005498 11431660 5330286

Interventional clinical trials:

(show top 50) (show all 111)
# Name Status NCT ID Phase Drugs
1 SIOP CNS GCT II: Prospective Trial for the Diagnosis and Treatment of Children, Adolescents and Young Adults With Intracranial Germ Cell Tumors Unknown status NCT01424839 Phase 4 Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
2 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
3 Safety and Efficacy of Antiadhesive Barrier GUARDIX-FL for Women After Laparoscopic Cystectomy : A Prospective, Randomized, Controlled Study Unknown status NCT02097446 Phase 3
4 Protocol for the Treatment of Extracranial Germ Cell Tumours in Children and Adolescents (GC III) Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
5 A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors Unknown status NCT00053352 Phase 3 cisplatin;etoposide
6 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
7 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
8 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
9 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
10 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
11 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
12 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
13 A Randomized Phase III Study of Sodium Thiosulfate for the Prevention of Cisplatin-Induced Ototoxicity in Children Completed NCT00716976 Phase 3 sodium thiosulfate
14 Randomized Controlled Trial of Acupressure to Control Chemotherapy-Induced Nausea (CIN) in Children Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
15 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
16 A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
17 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
18 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
19 Tandem High-Dose Chemotherapy (HDCT) With Peripheral-Blood Stem-Cell Rescue for Patients With Metastatic Germ-Cell Tumors Failing First-Line Treatment Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
20 Clinical Correlative Studies In Primary Central Nervous System Germ Cell Tumors: The Third International CNS Germ Cell Tumor Study Group Protocol Unknown status NCT00025324 Phase 2 carboplatin;cyclophosphamide;etoposide;thiotepa
21 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
22 A Multicenter, Randomized, Controlled Study of the Efficacy and Safety of the Combination of Adipose Tissue-derived Hematopoietic Stem Cells (AD-HSCs) and ATG in the Treatment of Severe Aplastic Anemia Unknown status NCT02407470 Phase 1, Phase 2 Rabbit antithymoglobulin (ATG)
23 A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression Completed NCT02300987 Phase 2 LEE011;LEE011 Placebo
24 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
25 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
26 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
27 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
28 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
29 A Study of Paclitaxel, Cisplatin and Ifosfamide as Induction Therapy in the Treatment of Patients Relapsing After BEP Chemotherapy for Metastatic Germ Cell Tumors Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
30 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
31 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
32 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
33 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
34 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
35 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
36 Anti-1-amino-3-18F-flurocyclobutane-1-carboxylic Acid (Axumin) Positron Emission Tomography/Computed Tomography Prior to Retroperitoneal Lymph Node Dissection for Testicular Cancer Completed NCT03426865 Phase 2 Axumin PET scan
37 Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
38 Phase 2 Study Of Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa Completed NCT01560715 Phase 2
39 Phase II Pre-Irradiation Chemotherapy for Central Nervous System Germ Cell Malignancies Completed NCT00002472 Phase 2 cisplatin;etoposide
40 A Phase II Study of Oxaliplatin in Children With Recurrent Solid Tumors Completed NCT00091182 Phase 2 oxaliplatin
41 PHASE II TRIAL WITH DOCETAXEL IN PATIENTS WITH RELAPSING GERM CELL CANCER Completed NCT00002903 Phase 2 docetaxel
42 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Completed NCT01037790 Phase 2 PD-0332991
43 Phase II Study of Arsenic Trioxide in Neuroblastoma and Other Pediatric Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
44 Phase II Treatment of Children With Newly Diagnosed Malignant Central Nervous System Tumors With Temozolomide Prior to Radiation Therapy Completed NCT00005955 Phase 2 temozolomide
45 High-Dose Cisplatin, Etoposide and Bleomycin (HD-PEB) Combined With Amifostine in Children With High-Risk Malignant Germ Cell Tumors - A POG Pilot Study Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
46 High-Dose Thiotepa With Autologous Stem Cell Rescue in Patients With Malignancies Refractory to Conventional Chemotherapy Completed NCT00003173 Phase 2 thiotepa
47 A Phase II Study To Assess The Ability Of Neoadjuvant Chemotherapy Plus/Minus Second Look Surgery To Eliminate All Measurable Disease Prior To Radiotherapy For NGGCT Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
48 Phase II Study of Avelumab in Multiple Relapsed/Refractory Testicular Germ Cell Cancer. Completed NCT03403777 Phase 2 Avelumab
49 PROTOCOL FOR THE TREATMENT OF MALIGNANT NON-TESTICULAR GERM CELL TUMORS Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
50 Sequential High-Dose Chemotherapy Combining Two Mobilization and Cyto-Reductive Treatments Followed by Three High-Dose Chemotherapy Regimens Supported by Autologous Stem Cell Transplantation Completed NCT00231582 Phase 2 epirubicin;paclitaxel;etoposide;ifosfamide;carboplatin

Search NIH Clinical Center for Teratoma

Cochrane evidence based reviews: teratoma

Genetic Tests for Teratoma

Anatomical Context for Teratoma

MalaCards organs/tissues related to Teratoma:

40
Ovary, Testis, Thyroid, Pineal, Brain, Lymph Node, Bone

Publications for Teratoma

Articles related to Teratoma:

(show top 50) (show all 14530)
# Title Authors PMID Year
1
Generation of induced pluripotent stem cells from newborn marmoset skin fibroblasts. 61 54
20363201 2010
2
Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells. 54 61
19785009 2010
3
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. 61 54
19826408 2009
4
Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours. 54 61
19912360 2009
5
Results of retroperitoneal lymph node dissection after chemotherapy in patients with pure seminoma in the orchidectomy specimen but elevated serum alpha-fetoprotein. 54 61
19493258 2009
6
Basic FGF and Activin/Nodal but not LIF signaling sustain undifferentiated status of rabbit embryonic stem cells. 54 61
19331817 2009
7
Alpha-fetoprotein levels correlate with the pathologic grade and surgical outcomes of pediatric retroperitoneal teratomas. 54 61
19198853 2009
8
Yolk sac tumor but not seminoma or teratoma is associated with abnormal epigenetic reprogramming pathway and shows frequent hypermethylation of various tumor suppressor genes. 54 61
19245437 2009
9
Progression from an immature teratoma with miliary gliomatosis peritonei to growing teratoma syndrome with nodular gliomatosis peritonei. 61 54
19453084 2009
10
Long-term outcome for men with teratoma found at postchemotherapy retroperitoneal lymph node dissection. 61 54
19156903 2009
11
Isolation of three stem cell lines from human sacrococcygeal teratomas. 61 54
19142973 2009
12
Pineal region tumors--neurosurgical review. 61 54
20088167 2009
13
Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature. 61 54
19577382 2009
14
Distinct GAGE and MAGE-A expression during early human development indicate specific roles in lineage differentiation. 54 61
18611917 2008
15
The distinction of bronchogenic cyst from metastatic testicular teratoma: a light microscopic and immunohistochemical study. 54 61
18628097 2008
16
Neuron-like differentiation and selective ablation of undifferentiated embryonic stem cells containing suicide gene with Oct-4 promoter. 61 54
18393636 2008
17
Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study. 61 54
18525461 2008
18
Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. 61 54
18439155 2008
19
Oncofetal protein glypican-3 distinguishes yolk sac tumor from clear cell carcinoma of the ovary. 61 54
18277882 2008
20
FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin. 61 54
17875810 2007
21
Analyses of novel prognostic factors in neuroblastoma patients. 61 54
18057715 2007
22
Comparative growth behaviour and characterization of stem cells from human Wharton's jelly. 61 54
18062871 2007
23
Expression of Sox2 in mature and immature teratomas of central nervous system. 54 61
17464316 2007
24
Regulated Nodal signaling promotes differentiation of the definitive endoderm and mesoderm from ES cells. 54 61
17535850 2007
25
[Malignant ovarian germ cell tumours: a trial of 36 cases]. 61 54
17350873 2007
26
Glypican 3: a novel marker in testicular germ cell tumors. 54 61
17122513 2006
27
Oncofetal protein glypican-3 in testicular germ-cell tumor. 61 54
16896894 2006
28
Characterization and gene expression profiling of five new human embryonic stem cell lines derived in Taiwan. 54 61
16978057 2006
29
Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma. 54 61
16718353 2006
30
Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression. 61 54
16596424 2006
31
TGF-beta2 allows pluripotent human embryonic stem cell proliferation on E6/E7 immortalized mouse embryonic fibroblasts. 54 61
16494961 2006
32
Pineal region teratoma with high serum and CSF alpha-fetoprotein levels. 61 54
16503489 2006
33
Malignant cervical teratoma: report of a case in a newborn. 61 54
15895292 2005
34
Transcription factor GATA-6 is expressed in malignant endoderm of pediatric yolk sac tumors and in teratomas. 61 54
16006960 2005
35
Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development. 61 54
15774903 2005
36
Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors. 54 61
16512597 2005
37
Interpretation of alpha-fetoprotein concentrations in cerebrospinal fluid of infants. 61 54
15802029 2005
38
Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. 61 54
15613854 2005
39
[The value of cytology in the diagnosis of extragonadal germ cell tumors]. 61 54
15567952 2004
40
Epidemiological and clinical behavior of prepubertal testicular tumors in Korea. 54 61
15247758 2004
41
[Clinical usefulness of circulating tumor markers]. 54 61
15272600 2004
42
Nestin, a neuroectodermal stem cell marker molecule, is expressed in Leydig cells of the human testis and in some specific cell types from human testicular tumours. 54 61
15127288 2004
43
Intracranial germ cell tumors: a single institution experience and review of the literature. 54 61
15218952 2004
44
Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. 54 61
14663834 2003
45
Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells. 61 54
12161760 2002
46
Malignant teratoma of the thyroid with primitive neuroepithelial and mesenchymal sarcomatous components. 54 61
11598856 2001
47
Apoptosis and proliferative activity in mature and immature teratomas of the mediastinum. 61 54
11745252 2001
48
Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. 61 54
10760271 2000
49
Transcription factor GATA-4 is expressed in pediatric yolk sac tumors. 54 61
10595911 1999
50
Methylation imprinting of H19 and SNRPN genes in human benign ovarian teratomas. 61 54
10521301 1999

Variations for Teratoma

ClinVar genetic disease variations for Teratoma:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CTNNB1 NM_001904.4(CTNNB1):c.1876G>T (p.Glu626Ter)SNV Likely pathogenic 523403 rs1553632357 3:41277912-41277912 3:41236421-41236421
2 SETBP1 NM_015559.3(SETBP1):c.2614G>A (p.Gly872Arg)SNV Likely pathogenic 523513 rs1555706928 18:42531919-42531919 18:44951954-44951954

Expression for Teratoma

Search GEO for disease gene expression data for Teratoma.

Pathways for Teratoma

GO Terms for Teratoma

Cellular components related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 KIT GRN ENO2 CGB7 CGB3 CGA
2 nuclear chromatin GO:0000790 9.17 TP53 SOX2 POU5F1 NKX2-1 MNX1 DMRT1

Biological processes related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.88 TP53 SOX2 POU5F1 NKX2-1 DMRT1 CDX2
2 positive regulation of gene expression GO:0010628 9.77 TP53 POU5F1 NKX2-1 KIT ACTC1
3 response to wounding GO:0009611 9.5 SOX2 POU5F1 GFAP
4 germ cell migration GO:0008354 9.26 KIT DMRT1
5 somatic stem cell population maintenance GO:0035019 9.26 SOX2 POU5F1 KIT CDX2
6 regulation of transcription by RNA polymerase II GO:0006357 9.23 TP53 POU5F1 NKX2-1 MNX1 KIT CGB3
7 endodermal cell fate specification GO:0001714 9.16 SOX2 POU5F1

Molecular functions related to Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.63 SOX2 POU5F1 NKX2-1 MNX1 DMRT1 CDX2
2 DNA-binding transcription factor activity GO:0003700 9.5 TP53 SOX2 POU5F1 NKX2-1 MNX1 DMRT1
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.17 TP53 SOX2 POU5F1 NKX2-1 MNX1 DMRT1

Sources for Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
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45 MGI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
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61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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