MCID: TRT002
MIFTS: 21

Tertiary Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Tertiary Neurosyphilis

MalaCards integrated aliases for Tertiary Neurosyphilis:

Name: Tertiary Neurosyphilis 12 15
Late Syphilis of Central Nervous System Nos 70
Late Neurosyphilis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9988
ICD9CM 34 094
MeSH 44 D009494
NCIt 50 C84935
SNOMED-CT 67 154384001
ICD10 32 A52.3
UMLS 70 C0027927 C1406891

Summaries for Tertiary Neurosyphilis

Disease Ontology : 12 A tertiary syphilis that results in infection located in brain or located in spinal cord.

MalaCards based summary : Tertiary Neurosyphilis, also known as late syphilis of central nervous system nos, is related to meningovascular neurosyphilis and asymptomatic neurosyphilis. An important gene associated with Tertiary Neurosyphilis is CXCL13 (C-X-C Motif Chemokine Ligand 13). Affiliated tissues include spinal cord and skin.

Related Diseases for Tertiary Neurosyphilis

Diseases related to Tertiary Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 meningovascular neurosyphilis 31.8 TCHH CXCL13 CD4
2 asymptomatic neurosyphilis 31.1 ITPA CXCL13 CD4 CCL15
3 tabes dorsalis 30.6 TCHH SPTLC1 PCNX2 FXN CXCL13 CD4
4 syphilis 30.4 TPR CD4
5 tertiary syphilis 29.6 TPR TCHH CXCL13 CD4
6 parenchymatous neurosyphilis 11.2
7 polyclonal hypergammaglobulinemia 10.2 CXCL13 CD4
8 early yaws 10.2 TPR CD4
9 congenital syphilis 10.2 TPR CD4
10 facial nerve disease 10.2 CXCL13 CD4
11 multicentric castleman disease 10.2 CXCL13 CD4
12 cardiovascular syphilis 10.2 TPR TCHH
13 gummatous syphilis 10.2 TPR TCHH
14 castleman disease 10.2 CXCL13 CD4
15 central nervous system hematologic cancer 10.2 CXCL13 CD4
16 west nile encephalitis 10.1 ITPA CD4
17 autoimmune disease of exocrine system 10.1 CXCL13 CD4
18 neurosyphilis 10.1
19 noonan syndrome 4 10.1 ITPA CD4
20 mature t-cell and nk-cell lymphoma 10.1 CXCL13 CD4
21 adenosine deaminase deficiency 10.1 ITPA CD4
22 secondary syphilis 10.1 TPR CXCL13 CD4
23 syphilitic meningitis 10.0 TCHH CXCL13 CD4
24 pleural disease 10.0 CXCL13 CD4
25 progressive multifocal leukoencephalopathy 10.0 NEFL CD4
26 postinfectious encephalitis 10.0 CXCL13 CCL15
27 charcot-marie-tooth disease type x 9.9 SPTLC1 NEFL
28 charcot-marie-tooth disease, axonal, type 2l 9.9 SPTLC1 NEFL
29 charcot-marie-tooth disease, x-linked dominant, 1 9.9 SPTLC1 NEFL
30 charcot-marie-tooth disease, axonal, type 2d 9.9 SPTLC1 NEFL
31 charcot-marie-tooth disease, axonal, type 2b 9.9 SPTLC1 NEFL
32 optic nerve disease 9.9 NEFL FXN CD4
33 disease by infectious agent 9.9
34 chronic meningitis 9.9
35 lyme disease 9.9
36 skin disease 9.9
37 charcot-marie-tooth disease, demyelinating, type 1a 9.9 SPTLC1 NEFL
38 meningoencephalitis 9.9
39 cranial nerve disease 9.9 NEFL CD4
40 latent syphilis 9.8 TPR PCNX2 CXCL13 CD4
41 hypertrophic neuropathy of dejerine-sottas 9.8 SPTLC1 NEFL
42 primary syphilis 9.8 TPR CD4 CCL15
43 sensory peripheral neuropathy 9.6 SPTLC1 FXN
44 neuromuscular disease 9.6 SPTLC1 NEFL FXN
45 peripheral nervous system disease 9.6 SPTLC1 NEFL FXN CD4

Graphical network of the top 20 diseases related to Tertiary Neurosyphilis:



Diseases related to Tertiary Neurosyphilis

Symptoms & Phenotypes for Tertiary Neurosyphilis

Drugs & Therapeutics for Tertiary Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Tertiary Neurosyphilis

Genetic Tests for Tertiary Neurosyphilis

Anatomical Context for Tertiary Neurosyphilis

MalaCards organs/tissues related to Tertiary Neurosyphilis:

40
Spinal Cord, Skin

Publications for Tertiary Neurosyphilis

Articles related to Tertiary Neurosyphilis:

(show all 11)
# Title Authors PMID Year
1
Neurosyphilis Masquerading as Stroke in an 84-year-old. 61
29967874 2017
2
Stroke in a young patient with neurosyphilis and HIV. 61
27510644 2017
3
Neurocognitive changes in tertiary neurosyphilis: a retrospective chart review. 61
24878469 2014
4
A case of tertiary neurosyphilis presenting with moth-eaten bone lesions. 61
24552413 2013
5
Syphilis as a diagnosis of liver abnormalities in HIV. 61
23672509 2013
6
Chronic or late lyme neuroborreliosis: analysis of evidence compared to chronic or late neurosyphilis. 61
23346260 2012
7
Case report: Neuropathic arthropathy of the hip as a sequela of undiagnosed tertiary syphilis. 61
20151233 2010
8
Neurosyphilis in a young adult: very early tertiary syphilis? 61
16336771 2005
9
Meningovascular form of neuroborreliosis: similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. 61
2251916 1990
10
Voiding dysfunction in tertiary syphilis. 61
3629778 1987
11
Concurrent neocortical borreliosis and Alzheimer's disease. 61
3297997 1987

Variations for Tertiary Neurosyphilis

Expression for Tertiary Neurosyphilis

Search GEO for disease gene expression data for Tertiary Neurosyphilis.

Pathways for Tertiary Neurosyphilis

GO Terms for Tertiary Neurosyphilis

Biological processes related to Tertiary Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine-mediated signaling pathway GO:0070098 8.96 CXCL13 CCL15
2 intermediate filament organization GO:0045109 8.62 TCHH NEFL

Molecular functions related to Tertiary Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 CXCL13 CCL15

Sources for Tertiary Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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