MCID: TRT002
MIFTS: 26

Tertiary Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Tertiary Neurosyphilis

MalaCards integrated aliases for Tertiary Neurosyphilis:

Name: Tertiary Neurosyphilis 12 15
Late Syphilis of Central Nervous System Nos 73
Late Neurosyphilis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9988
ICD10 33 A52.3
ICD9CM 35 094 094.9
MeSH 44 D009494
NCIt 50 C84935
SNOMED-CT 68 26039008

Summaries for Tertiary Neurosyphilis

Disease Ontology : 12 A tertiary syphilis that results in infection located in brain or located in spinal cord.

MalaCards based summary : Tertiary Neurosyphilis, also known as late syphilis of central nervous system nos, is related to parenchymatous neurosyphilis and asymptomatic neurosyphilis. An important gene associated with Tertiary Neurosyphilis is EXTL3 (Exostosin Like Glycosyltransferase 3). Affiliated tissues include brain, spinal cord and bone, and related phenotypes are cellular and mortality/aging

Related Diseases for Tertiary Neurosyphilis

Diseases related to Tertiary Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 parenchymatous neurosyphilis 31.9 EXTL3 FLYWCH1 MBP
2 asymptomatic neurosyphilis 31.1 CXCL10 CXCL13 DDX41 EXTL3 GRM1 ITPA
3 neurosyphilis 30.2 CXCL10 CXCL13
4 tabes dorsalis 30.0 CXCL13 DDX41 EXTL3 FXN KANTR KCNA5
5 syphilis 29.9 DDX41 EXTL3 MYH9
6 tertiary syphilis 29.6 DDX41 EXTL3 LEFTY2 MYH9 SH3BP5 SPTLC1
7 meningovascular neurosyphilis 11.3
8 late congenital syphilis 10.2 DDX41 EXTL3
9 secondary syphilis 10.2 DDX41 EXTL3
10 charcot-marie-tooth disease, axonal, type 2b 10.1 RAB7A SPTLC1
11 primary syphilis 10.1 DDX41 EXTL3 MYH9
12 latent syphilis 10.1 DDX41 EXTL3 MYH9
13 congenital syphilis 10.1 DDX41 EXTL3 MYH9
14 apical myocardial infarction 10.1 KANTR LEFTY2
15 primary bacterial infectious disease 10.1 CXCL10 DDX41 EXTL3
16 oculomotor nerve paralysis 10.0 KANTR MBP
17 brown-sequard syndrome 10.0 KANTR TCHH
18 alexia 10.0 KANTR MBP
19 neuropathy, hereditary sensory and autonomic, type ia 10.0 NAA50 SPTLC1
20 japanese spotted fever 10.0 CXCL10 KANTR
21 third cranial nerve disease 10.0 KANTR MBP
22 autoimmune disease of peripheral nervous system 10.0 DDX41 MBP
23 acute retrobulbar neuritis 10.0 MBP MYH9
24 autoimmune disease of the nervous system 10.0 CXCL10 DDX41 MBP
25 anterior spinal artery syndrome 9.9 KANTR MBP TCHH
26 central nervous system disease 9.9 FXN GRM1 MBP
27 neurogenic arthropathy 9.9 NAA50 RAB7A SPTLC1
28 nervous system disease 9.9 FXN KANTR MBP
29 lyme disease 9.8
30 internuclear ophthalmoplegia 9.8 KANTR MBP
31 peripheral nervous system disease 9.7 KANTR MBP NAA50 SPTLC1

Graphical network of the top 20 diseases related to Tertiary Neurosyphilis:



Diseases related to Tertiary Neurosyphilis

Symptoms & Phenotypes for Tertiary Neurosyphilis

MGI Mouse Phenotypes related to Tertiary Neurosyphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 CXCL10 CXCL13 EXTL3 FXN GRM1 ITPA
2 mortality/aging MP:0010768 9.4 CXCL10 DDX41 EXTL3 FXN GRM1 ITPA

Drugs & Therapeutics for Tertiary Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Tertiary Neurosyphilis

Genetic Tests for Tertiary Neurosyphilis

Anatomical Context for Tertiary Neurosyphilis

MalaCards organs/tissues related to Tertiary Neurosyphilis:

41
Brain, Spinal Cord, Bone

Publications for Tertiary Neurosyphilis

Articles related to Tertiary Neurosyphilis:

# Title Authors Year
1
Neurocognitive changes in tertiary neurosyphilis: a retrospective chart review. ( 24878469 )
2014
2
A case of tertiary neurosyphilis presenting with moth-eaten bone lesions. ( 24552413 )
2013
3
Meningovascular form of neuroborreliosis: similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. ( 2251916 )
1990

Variations for Tertiary Neurosyphilis

Expression for Tertiary Neurosyphilis

Search GEO for disease gene expression data for Tertiary Neurosyphilis.

Pathways for Tertiary Neurosyphilis

GO Terms for Tertiary Neurosyphilis

Biological processes related to Tertiary Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte chemotaxis GO:0030595 8.62 CXCL10 CXCL13

Molecular functions related to Tertiary Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CXCR3 chemokine receptor binding GO:0048248 8.62 CXCL10 CXCL13

Sources for Tertiary Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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