MCID: TRT002
MIFTS: 21

Tertiary Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Tertiary Neurosyphilis

MalaCards integrated aliases for Tertiary Neurosyphilis:

Name: Tertiary Neurosyphilis 12 15
Late Syphilis of Central Nervous System Nos 74
Late Neurosyphilis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9988
ICD9CM 36 094 094.9
MeSH 45 D009494
NCIt 51 C84935
SNOMED-CT 69 26039008
ICD10 34 A52.3

Summaries for Tertiary Neurosyphilis

Disease Ontology : 12 A tertiary syphilis that results in infection located in brain or located in spinal cord.

MalaCards based summary : Tertiary Neurosyphilis, also known as late syphilis of central nervous system nos, is related to asymptomatic neurosyphilis and tabes dorsalis. An important gene associated with Tertiary Neurosyphilis is EXTL3 (Exostosin Like Glycosyltransferase 3). Affiliated tissues include brain and spinal cord, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Tertiary Neurosyphilis

Diseases related to Tertiary Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 32.2 DDX41 EXTL3
2 tabes dorsalis 30.3 DDX41 EXTL3 KCNA5 SH3BP5 SPTLC1
3 syphilis 29.8 DDX41 EXTL3
4 tertiary syphilis 28.8 DDX41 EXTL3 SH3BP5 SPTLC1
5 parenchymatous neurosyphilis 11.3
6 meningovascular neurosyphilis 11.3
7 neurosyphilis 10.1
8 late congenital syphilis 10.0 DDX41 EXTL3
9 congenital syphilis 10.0 DDX41 EXTL3
10 primary syphilis 9.9 DDX41 EXTL3
11 latent syphilis 9.9 DDX41 EXTL3
12 secondary syphilis 9.9 DDX41 EXTL3
13 lyme disease 9.9
14 primary bacterial infectious disease 9.7 DDX41 EXTL3

Graphical network of the top 20 diseases related to Tertiary Neurosyphilis:



Diseases related to Tertiary Neurosyphilis

Symptoms & Phenotypes for Tertiary Neurosyphilis

GenomeRNAi Phenotypes related to Tertiary Neurosyphilis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.17 SPTLC1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.17 DDX41
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.17 SPTLC1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.17 DDX41 SPTLC1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.17 DDX41 SPTLC1

Drugs & Therapeutics for Tertiary Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Tertiary Neurosyphilis

Genetic Tests for Tertiary Neurosyphilis

Anatomical Context for Tertiary Neurosyphilis

MalaCards organs/tissues related to Tertiary Neurosyphilis:

42
Brain, Spinal Cord

Publications for Tertiary Neurosyphilis

Articles related to Tertiary Neurosyphilis:

# Title Authors Year
1
Neurocognitive changes in tertiary neurosyphilis: a retrospective chart review. ( 24878469 )
2014
2
A case of tertiary neurosyphilis presenting with moth-eaten bone lesions. ( 24552413 )
2013
3
Meningovascular form of neuroborreliosis: similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. ( 2251916 )
1990

Variations for Tertiary Neurosyphilis

Expression for Tertiary Neurosyphilis

Search GEO for disease gene expression data for Tertiary Neurosyphilis.

Pathways for Tertiary Neurosyphilis

GO Terms for Tertiary Neurosyphilis

Cellular components related to Tertiary Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 8.92 DDX41 EXTL3 KCNA5 SPTLC1

Sources for Tertiary Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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