MCID: TRT002
MIFTS: 22

Tertiary Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Tertiary Neurosyphilis

MalaCards integrated aliases for Tertiary Neurosyphilis:

Name: Tertiary Neurosyphilis 12 15
Late Syphilis of Central Nervous System Nos 71
Late Neurosyphilis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9988
ICD9CM 34 094
MeSH 43 D009494
NCIt 49 C84935
SNOMED-CT 67 26039008
ICD10 32 A52.3
UMLS 71 C0027927 C1406891

Summaries for Tertiary Neurosyphilis

Disease Ontology : 12 A tertiary syphilis that results in infection located in brain or located in spinal cord.

MalaCards based summary : Tertiary Neurosyphilis, also known as late syphilis of central nervous system nos, is related to meningovascular neurosyphilis and asymptomatic neurosyphilis. An important gene associated with Tertiary Neurosyphilis is FLYWCH1 (FLYWCH-Type Zinc Finger 1). Affiliated tissues include brain, spinal cord and bone.

Related Diseases for Tertiary Neurosyphilis

Diseases related to Tertiary Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 meningovascular neurosyphilis 32.1 MYH9 CXCL13 CD40LG CD4
2 asymptomatic neurosyphilis 32.0 MYH9 ITPA CXCL13 CD40LG CD4
3 chronic meningitis 30.4 CD40LG CD4
4 syphilis 29.8 MYH9 DDX41 CD40LG CD4
5 tabes dorsalis 28.9 PCNX2 MYH9 JRK FXN DDX41 CXCL13
6 tertiary syphilis 28.6 MYH9 FLYWCH1 DDX41 CXCL13 CNST CD40LG
7 parenchymatous neurosyphilis 11.5
8 eye lymphoma 10.4 CXCL13 CD4
9 cork-handlers' disease 10.4 CD40LG CD4
10 american histoplasmosis 10.4 CD40LG CD4
11 histoplasmosis 10.4 CD40LG CD4
12 early yaws 10.4 CD40LG CD4
13 gastroduodenitis 10.4 CD40LG CD4
14 duodenitis 10.4 CD40LG CD4
15 norwegian scabies 10.4 CD40LG CD4
16 necrotizing ulcerative gingivitis 10.4 CD40LG CD4
17 neuroretinitis 10.4 CD40LG CD4
18 bacillary angiomatosis 10.4 CD40LG CD4
19 viral exanthem 10.4 CD40LG CD4
20 acute retinal necrosis syndrome 10.4 CD40LG CD4
21 opportunistic bacterial infectious disease 10.4 CD40LG CD4
22 cerebral lymphoma 10.4 CD40LG CD4
23 gastrointestinal tuberculosis 10.4 CD40LG CD4
24 cerebritis 10.4 CD40LG CD4
25 granulomatous hepatitis 10.4 CD40LG CD4
26 exanthema subitum 10.4 CD40LG CD4
27 mikulicz disease 10.4 CD40LG CD4
28 autoimmune peripheral neuropathy 10.4 CD40LG CD4
29 trichinosis 10.4 CD40LG CD4
30 mononeuritis of upper limb and mononeuritis multiplex 10.4 CD40LG CD4
31 mononeuritis multiplex 10.4 CD40LG CD4
32 granulomatous dermatitis 10.4 CD40LG CD4
33 chancroid 10.4 CD40LG CD4
34 cat-scratch disease 10.4 CD40LG CD4
35 parotid disease 10.4 CD40LG CD4
36 aortitis 10.4 CD40LG CD4
37 west nile fever 10.4 CD40LG CD4
38 splenic sequestration 10.4 CD40LG CD4
39 bartonellosis 10.4 CD40LG CD4
40 mastoiditis 10.4 CD40LG CD4
41 abdominal tuberculosis 10.4 CD40LG CD4
42 paralytic poliomyelitis 10.4 CD40LG CD4
43 cervical adenitis 10.4 CD40LG CD4
44 blastomycosis 10.4 CD40LG CD4
45 autoimmune neuropathy 10.4 CD40LG CD4
46 scleral disease 10.4 CD40LG CD4
47 lung abscess 10.4 CD40LG CD4
48 adenoid hypertrophy 10.4 CD40LG CD4
49 chlamydia pneumonia 10.4 CD40LG CD4
50 mite infestation 10.4 CD40LG CD4

Graphical network of the top 20 diseases related to Tertiary Neurosyphilis:



Diseases related to Tertiary Neurosyphilis

Symptoms & Phenotypes for Tertiary Neurosyphilis

Drugs & Therapeutics for Tertiary Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Tertiary Neurosyphilis

Genetic Tests for Tertiary Neurosyphilis

Anatomical Context for Tertiary Neurosyphilis

MalaCards organs/tissues related to Tertiary Neurosyphilis:

40
Brain, Spinal Cord, Bone, Liver

Publications for Tertiary Neurosyphilis

Articles related to Tertiary Neurosyphilis:

(show all 11)
# Title Authors PMID Year
1
Neurosyphilis Masquerading as Stroke in an 84-year-old. 61
29967874 2017
2
Stroke in a young patient with neurosyphilis and HIV. 61
27510644 2017
3
Neurocognitive changes in tertiary neurosyphilis: a retrospective chart review. 61
24878469 2014
4
A case of tertiary neurosyphilis presenting with moth-eaten bone lesions. 61
24552413 2013
5
Syphilis as a diagnosis of liver abnormalities in HIV. 61
23672509 2013
6
Chronic or late lyme neuroborreliosis: analysis of evidence compared to chronic or late neurosyphilis. 61
23346260 2012
7
Case report: Neuropathic arthropathy of the hip as a sequela of undiagnosed tertiary syphilis. 61
20151233 2010
8
Neurosyphilis in a young adult: very early tertiary syphilis? 61
16336771 2005
9
Meningovascular form of neuroborreliosis: similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. 61
2251916 1990
10
Voiding dysfunction in tertiary syphilis. 61
3629778 1987
11
Concurrent neocortical borreliosis and Alzheimer's disease. 61
3297997 1987

Variations for Tertiary Neurosyphilis

Expression for Tertiary Neurosyphilis

Search GEO for disease gene expression data for Tertiary Neurosyphilis.

Pathways for Tertiary Neurosyphilis

GO Terms for Tertiary Neurosyphilis

Sources for Tertiary Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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