MCID: TRT002
MIFTS: 29

Tertiary Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Tertiary Neurosyphilis

MalaCards integrated aliases for Tertiary Neurosyphilis:

Name: Tertiary Neurosyphilis 12 15
Late Syphilis of Central Nervous System Nos 73
Late Neurosyphilis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9988
ICD10 33 A52.3
ICD9CM 35 094 094.9
MeSH 44 D009494
NCIt 50 C84935

Summaries for Tertiary Neurosyphilis

Disease Ontology : 12 A tertiary syphilis that results in infection located in brain or located in spinal cord.

MalaCards based summary : Tertiary Neurosyphilis, also known as late syphilis of central nervous system nos, is related to meningovascular neurosyphilis and parenchymatous neurosyphilis. An important gene associated with Tertiary Neurosyphilis is EXTL3 (Exostosin Like Glycosyltransferase 3). Affiliated tissues include brain or, brain and spinal cord, and related phenotypes are cellular and hematopoietic system

Related Diseases for Tertiary Neurosyphilis

Diseases related to Tertiary Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 meningovascular neurosyphilis 32.1 CD40LG CD79A MBP
2 parenchymatous neurosyphilis 31.6 EXTL3 FLYWCH1 MBP
3 neurosyphilis 29.6 CXCL10 CXCL13
4 asymptomatic neurosyphilis 27.7 CD40LG CD79A CXCL10 CXCL13 DDX41 EXTL3
5 tabes dorsalis 27.7 CD79A DDX41 EXTL3 FXN KCNA5 LEFTY2
6 late congenital syphilis 11.0 DDX41 EXTL3
7 syphilitic meningitis 11.0 CD40LG EXTL3
8 cardiovascular syphilis 11.0 CD40LG DDX41
9 optic papillitis 11.0 CD40LG EXTL3
10 focal chorioretinitis 10.9 CD40LG DDX41
11 selective igg deficiency disease 10.9 CD40LG CD79A
12 c1q nephropathy 10.9 CD40LG CD79A
13 alpha chain disease 10.9 CD40LG CD79A
14 brill-zinsser disease 10.9 CD40LG CD79A
15 exudative glomerulonephritis 10.9 CD40LG CD79A
16 cork-handlers' disease 10.9 CD40LG CD79A
17 salpingo-oophoritis 10.9 CD40LG CD79A
18 ventilation pneumonitis 10.9 CD40LG CD79A
19 chronic interstitial cystitis 10.9 CD40LG CD79A
20 axillary adenitis 10.9 CD40LG CD79A
21 cryofibrinogenemia 10.9 CD40LG CD79A
22 trichostrongyloidiasis 10.8 CD40LG CD79A
23 subacute bacterial endocarditis 10.8 CD40LG CD79A
24 heterophyiasis 10.8 CD40LG CD79A
25 immunoglobulin g deficiency 10.8 CD40LG CD79A
26 orbital granuloma 10.8 CD40LG CD79A
27 transient hypogammaglobulinemia of infancy 10.8 CD40LG CD79A
28 hyperglobulinemic purpura 10.8 CD40LG CD79A
29 gastroduodenitis 10.8 CD40LG CD79A
30 early congenital syphilis 10.8 CD40LG MYH9
31 bacterial conjunctivitis 10.8 CD40LG CD79A
32 heavy chain disease 10.8 CD40LG CD79A
33 pontiac fever 10.8 CD40LG TRIM37
34 ophthalmia neonatorum 10.8 CD40LG CD79A
35 immunoglobulin a deficiency 1 10.8 CD40LG CD79A
36 parotid disease 10.8 CD40LG CD79A
37 cerebral arteritis 10.8 CD40LG CD79A
38 selective immunoglobulin deficiency disease 10.8 CD40LG CD79A
39 geniculate herpes zoster 10.8 CD40LG CD79A
40 erythema elevatum diutinum 10.7 CD40LG CD79A
41 sporotrichosis 10.7 CD40LG CD79A
42 fallopian tube disease 10.7 CD40LG CD79A
43 hyperimmunoglobulin syndrome 10.7 CD40LG CD79A
44 polyclonal hypergammaglobulinemia 10.7 CD40LG CD79A
45 early yaws 10.7 CD40LG CD79A EXTL3
46 chorioretinitis 10.7 CD40LG CD79A EXTL3
47 urethritis 10.7 CD40LG CD79A EXTL3
48 monoclonal paraproteinemia 10.7 CD40LG CD79A
49 salpingitis 10.7 CD40LG CD79A
50 endocardium disease 10.7 CD40LG CD79A SH3BP5

Graphical network of the top 20 diseases related to Tertiary Neurosyphilis:



Diseases related to Tertiary Neurosyphilis

Symptoms & Phenotypes for Tertiary Neurosyphilis

MGI Mouse Phenotypes related to Tertiary Neurosyphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.13 MYH9 EXTL3 RAB7A FXN GRM1 TRIM37
2 hematopoietic system MP:0005397 10 CXCL13 MYH9 RAB7A TRIM37 ITPA CD40LG
3 immune system MP:0005387 9.9 CXCL13 MYH9 FXN RAB7A CD40LG KCNA5
4 mortality/aging MP:0010768 9.77 MYH9 DDX41 EXTL3 FXN RAB7A SPTLC1
5 nervous system MP:0003631 9.36 MYH9 FXN SPTLC1 GRM1 CD40LG KCNA5

Drugs & Therapeutics for Tertiary Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Tertiary Neurosyphilis

Genetic Tests for Tertiary Neurosyphilis

Anatomical Context for Tertiary Neurosyphilis

The Foundational Model of Anatomy Ontology organs/tissues related to Tertiary Neurosyphilis:

19
Brain Or

MalaCards organs/tissues related to Tertiary Neurosyphilis:

41
Brain, Spinal Cord, Bone

Publications for Tertiary Neurosyphilis

Articles related to Tertiary Neurosyphilis:

# Title Authors Year
1
Neurocognitive changes in tertiary neurosyphilis: a retrospective chart review. ( 24878469 )
2014
2
A case of tertiary neurosyphilis presenting with moth-eaten bone lesions. ( 24552413 )
2013
3
Meningovascular form of neuroborreliosis: similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. ( 2251916 )
1990

Variations for Tertiary Neurosyphilis

Expression for Tertiary Neurosyphilis

Search GEO for disease gene expression data for Tertiary Neurosyphilis.

Pathways for Tertiary Neurosyphilis

GO Terms for Tertiary Neurosyphilis

Molecular functions related to Tertiary Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CD40LG CXCL10 CXCL13 LEFTY2
2 CXCR chemokine receptor binding GO:0045236 9.16 CXCL10 CXCL13
3 CXCR3 chemokine receptor binding GO:0048248 8.62 CXCL10 CXCL13

Sources for Tertiary Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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